The Human Upgrade: Biohacking for Longevity & Performance

IN THIS EPISODE OF THE HUMAN UPGRADE™... …two of the most adventurous people on the planet share what they’ve uncovered, faced and learned through exploration of the planet’s deepest waters. From discovering the Titanic to cave diving in places untouched by any other human, Bob Ballard and Jill Heinerth took risks, dove into fear, and came up for air with tremendous new knowledge. Combined, they’ve spent over nine decades searching the seas and documenting their findings. Canadian Jill Heinerth explores the underwater world as one of the greatest cave divers on the planet. She’s considered this generation’s Jacques Cousteau. She’s completed more than 7,500 dives in her career so far and dived deeper into caves than any woman in history. She became the first person to dive the ice caves of Antarctica, going further into an underwater cave system than any woman ever. She’s gone into places in the world where no one had gone before.Considered a legend in the diving community, she’s spent more than 30 years in submerged caves around the world partnering with National Geographic, NOAA, and various educational institutions and television networks worldwide. She’s also a writer and award-winning photographer and filmmaker who takes a keen interest in the health of the Earth’s oceans.Learn more about Jill’s lifetime of underwater cave diving in her memoir, “Into the Planet: My Life as a Cave Diver.” “We are capable of so much more than we could possibly imagine," she says.Bob Ballard explores the vast depths of the oceans uncovering mysteries, proving theories, and revealing artifacts that tell a story about the history of humankind. An oceanographer and marine geologist, he’s led nearly 160 deep-sea expeditions and worked with the Navy on top-secret missions. His underwater career spanning more than 60 years began simply enough as a child with a love of California’s Mission Bay tide pools.He’s gone on to discover ships thought long lost (the RMS Titanic in 1985) and provide extraordinary new understandings and discoveries in marine geology, geophysics, biology, and chemistry. He’s discovered new life-forms, traced ancient trade routes, developed robots that roam the ocean floor, and opened the underwater world to kids through telepresence. Bob's recent memoir chronicles his underwater journeys “Into The Deep: A Memoir from the Man Who Found Titanic.” “Just lots of crazy things have happened, and I'm still at it and I'm not going to quit,” he says.If you liked this special episode with Jill and Bob, you’ll learn even more from listening to their full podcasts, directly below.Living a Life of Deep Adventure – Bob Ballard, Finder of the Titanic – #839A Lesson in Adventure Hacking: Step Toward Your Fear – Jill Heinerth – #663WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Repair Oxidative Stress Damage: https://eng3corp.com/DAVE/Kickstart Autophagy: https://timelinenutrition.com/DAVE, use code ASPREY10 to get 10% off any planControl Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...…a legacy upgrade conversation with Paul Chek delivers the goods on how to improve your physical, emotional and mental performance. He lays out what it takes to get into your optimal state—including a higher state of consciousness. For more than 30 years, he’s used a unique, integrated approach to treatment and education. Paul gets back to basics and formulates practical systems that work to help you help yourself to get well.“I look at happiness, movement, quiet, and diet,” Paul says. “I get a holistic picture of their life because you can’t reduce a living philosophy below those four factors.”Paul's an expert in the fields of corrective and high-performance exercise kinesiology, stress management and holistic wellness. By treating the body as a whole system and finding the root cause of a problem, he’s been successful where traditional approaches have consistently failed. And he goes even further into the metaphysical realm.“The world populace due to the destruction of the environment, due to the chemicals in the environment, due to the electromagnetic pollution, due to overstimulation, due to the lack of sleep, due to the manipulation of people’s biochemistry by medical drug use, … we’re going lower and lower into our levels of consciousness, which is putting us more and more in a fight or flight state, which is making us more and more reactive.”But you can make a difference within your own life, even going into higher levels of consciousness, Paul explains.“Every human being has genius within it,” Paul says. “We can use the same technology and the same level of brain power that got us in trouble to reverse it.”This legacy episode is the full version of a 2-part episode series. Now, you can listen to the entire conversation without interruption. Paul tells it like it is—no holds barred and no BS. You’re going to learn a lot and enjoy his style!About Paul Chek:  Paul founded the CHEK Institute (Corrective Holistic Exercise Kinesiology) in 1995. He’s a certified neuromuscular therapist and clinical exercise specialist (ACE) who’s studied with experts worldwide from many disciplines. The Chek Institute offers a broad range of educational courses that include at-home study. WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Mattress Temperature Tech: https://www.eightsleep.com/dave, use code dave to save $250 on the Pod ProMust-Have Magnesium: https://magbreakthrough.com/DAVE, use code DAVE10 to get a 10% discountBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...…two spiritual masters continue discovering new layers of and models for human experience. This combined episode covers aspects of consciousness, conscious agents, biodynamics, emotional body energy, the Enneagram, homeopathy and much more.Deepak Chopra, M.D., FACP, is a world-renowned pioneer in integrative medicine and personal transformation. TIME magazine described him as “one of the top 100 heroes and icons of the century.” He’s been exploring the intersection of science and spirituality for decades.Deepak’s 90th book: “Metahuman: Unleashing Your Infinite Potential,” gets into what it means to be “beyond human.” You’ll learn how to question reality, move past limitations constructed by your mind, and enter a new state of awareness. And when you realize a “reality without limits,” you’ll be able to realize your full human potential.Abdul Hayy Lammert Holdijk has followed a Sufi path for the past 40 years, studying religion and consciousness with a hefty dose of pragmatism. He lectures on topics such as Epigenetics, Neurobiology, the Enneagram, Shadow Work, Voice Dialogue, Love, Dream interpretation, Jekyll and Hyde, Hayy Ibn Yaqzan, and a wide range of other topics related to consciousness and personality development. Abdul taught at the American University in Beirut for several years, and then at the American University in Cairo for 35. His profound life story includes adventure, spirituality seeking, questioning tradition and teaching others. He also leads spiritual retreats in Lebanon, Egypt, Oman, and the surrounding region.If you liked this special episode with Deepak and Abdul, you’ll learn even more from listening to their full podcasts, directly below.Going Beyond the Human Mind to Discover Your Infinite Potential – Deepak Chopra – #683Who Am I? Finding Spirituality by Disrupting Tradition with Abdul Hayy L. Holdijk – #710WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Complete Brain Nutrition with Nootropics: https://neurohacker.com/dave, use code DAVE to score an extra 15% off Qualia MindHydrate with Electrolytes: https://DrinkLMNT.com/DAVE, get a FREE LMNT Sample Pack with 8 single-serving packets for the cost of shipping ($5 for U.S. customers) Business Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™......you'll learn some surprising lessons sorrow and longing can teach you about creativity, connection and love. You’ll find out why longing isn’t passive—as most people think—but actually “momentum in disguise.”Author Susan Cain combines research, the stories of others, and memoir to explain how sadness can be your superpower. “Bittersweetness is the hidden source of our moon shots, masterpieces, and love stories,” she says in her newest book, “Bittersweet: "How Sorrow And Longing Make Us Whole”.Longing can improve your creativity and fuel a drive to express yourself. Longing coupled with pain can help you to connect to others and provide a common ground that enhances compassion and helps you feel less alone in your troubles. Instead of hiding or shying away from feelings like sadness and longing, Susan encourages you to embrace them as part of who you are, and part of what it means to be human. This conversation gets into:How bittersweet differs from melancholyHow Acceptance Commitment Therapy helps you manage the “bitter of life” How sadness is the ultimate bonding agentHow the concept of “winners” and “losers” changed over timeHow to live and work authentically in an environment of enforced positivityHow to embrace deep reflection and ask yourself: "What. Are. You. Longing. For?"Special offer for The Human Upgrade listeners: Go deeper into the topics of Bittersweet and Quiet with Susan’s 30-day interactive online courses. Go to https://www.susancain.net/ and use code ASPREY15 to save 15%.  More about Susan Cain: She’s the author of “QUIET: The Power of Introverts in a World That Can’t Stop Talking,” which spent seven years on The New York Times bestseller list and has been translated into 40 languages. Her record-smashing TED Talk, “The Power of Introverts,” has been viewed over 30 million times. She’s spoken at Microsoft, Google, the U.S. Treasury, the S.E.C., Harvard, Yale, West Point and the US Naval Academy. She’s an honors graduate of Princeton and Harvard Law School.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!A New Peptide Builds Healthier Skin: https://www.oneskin.co, use code DAVE15 to get 15% offTrigger Autophagy: https://spermidinelife.us/dave, use code DAVE25 for 25% off your first month’s order8th Annual Biohacking Conference:  https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Episode of The Human Upgrade™...​Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month. How a gene interferes with memory linking in the brain.How fearful memories are seared into your brain.How a new device stimulates the vagus nerve to help people learn a new language.How global warming impacts your sleep quality.How and why people age, according to a new theory.EPISODE SPONSOR: Infrared Sauna Benefits: https://www.sunlighten.com/dave. Save up to $600 on your sauna purchase! Mention code "DaveAsprey" for discount.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...…two food experts explain the many ways your food choices influence your body systems—and what you can do differently to improve your gut function, energy and performance. Here’s a look at how essential amino acids and the right proteins can keep inflammation at bay and keep your metabolism humming.Teri Cochrane, CN, CCP, went down the research rabbit hole when both her son and daughter (at different ages and for different reasons) experienced severe health problems. She not only examined nutrition in-depth, but she also investigated epigenetics and nutrigenomics “Disruptors such as pathogens, mycotoxins, stress, amyloids and inflammatory foods work together to impair body balance,” Teri says. “We have found a direct link between amyloids, mycotoxins and these health disruptors in the acceleration of disease.”She’s developed her own methodology that integrates a multi-level nutritional approach—including biochemistry, nutrition, genetic tendencies, herbology, supplementation and counseling. As the author of the “The Wildatarian Diet: Living as Nature Intended,” Teri lays out how the malabsorption of protein, fat, and sulfur, tamper with gene expression. Mareya Ibrahim believes in food flexibility while still focusing on a core system that works. She’s a holistic nutritionist, TV chef, podcast host, and award-winning entrepreneur and inventor with more than 25 years of experience in the food industry. She also founded Grow Green Industries and co-invented the patented eatCleaner line of products.In her book, “Eat Like You Give a Fork: The Real Dish on Eating to Thrive,” she explains the nuances of clean eating, how to reset your taste buds, and all the ways essential amino acids keep your body functioning.“Essential amino acids are what fuel us and allow us to regulate our hormones, and flex our metabolisms, and build muscle, and all of the things that we need to be functioning human beings,” Mareya says. If you liked this special episode with Teri and Mareya, you’ll learn even more from listening to their full podcasts,:What You Eat is Turning Your Genes On and Off – Teri Cochrane – #646Just Give a Fork: Eat the Freakin’ Pasta – Mareya Ibrahim – #661WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Meat Sticks! All the Good Stuff-No BS: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderFitness Center of the Future: Check out franchise opportunities for biohackers at https://ownanupgradelabs.comNAD+ for Brain Health: https://innovativemedicine.com/DAVE and save 20%See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

TWO SPECIAL OFFERS FOR LISTENERS OF THE HUMAN UPGRADE!  Visit https://paleovalley.com/humanupgrade to get your first 10-pack of meat sticks for only $4.99 + shipping.Visit https://wildpastures.com/dave to get a special discount for a limited time on regenerative meat delivery.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll learn how eating meat benefits human health, including protein specifics and the clear advantages of regenerative agriculture.Today’s guest suffered from debilitating digestive issues and crippling anxiety for most of her life. Specialist after specialist told Autumn Smith nothing could be done to alleviate her physical and mental health distress.As a last-ditch effort, she turned to the power of whole foods. She cleaned up her diet with Paleo-inspired eating and improved her gut in just 30 days. The changes also decreased her anxiety, increased her mental sharpness, and discovered her inner vibrancy. That experience propelled Autumn to help others capture the power of whole foods through quality food products produced by regenerative agricultural practices.In 2013, she and her husband, Chas, along with another family member and friend, launched Paleovalley. They built a company dedicated to helping people get essential nutrients without added sugars, grains, and other harmful ingredients. With meat being the central focus of their business, they set out to learn all they could about production and regenerative farming.In 2018, they launched Wild Pastures, a regenerative meat delivery service, and recently opened Wild Pastures Burger Company, their flagship fast casual burger restaurant in Boulder, Colorado.This conservation gets into the problems with current methods of animal agriculture and possible solutions. You’ll find out more about the nutritional differences of animal products depending on how they’re raised. Autumn says meat labels can be tricky, too, so she breaks down the jargon and tells you what to look for and what to avoid.Autumn advocates for meat’s many advantages and works to dispel the myths that continue to persist about meat consumption. From soil to farming to raising animals humanely, building community and managing economies, Autumn talks about how to make choices that are right for you and everything around you.More about Autumn Smith: Autumn holds a master’s in Holistic Nutrition and currently is a doctoral candidate in Holistic Nutrition. She’s a Functional Diagnostic Nutrition Practitioner, an Eating Psychology Coach certified by the Institute for the Psychology of Eating, and received Soil Advocacy Training by Kiss The Ground. She hosts the popular Optimize Paleo podcast.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Control Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentFitness Center of the Future: Check out franchise opportunities for biohackers at https://ownanupgradelabs.comMust-Have Magnesium: https://magbreakthrough.com/DAVE, use code DAVE10 to get a 10% discountSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Episode of The Human Upgrade™...​… Dave talks with Lisa B. about the frustration she’s experiencing with her health conditions. She says she lives a healthy lifestyle and does the “right things” and still struggles with chronic low energy. Her kids often say, “you never feel well, mom.” She agrees but finds it difficult to explain why. Now in her early 50s, she’s had panic attacks and anxiety since childhood and has taken many types of anti-depressants throughout her life. She also struggles with OCD.She’s experienced long-time hormonal imbalances, including painful periods, acne, fertility problems, and ongoing PMS “flu” that she says takes over her life during her cycles. She suffers from aggressive seasonal allergies and has a shellfish allergy. She’s been on Accutane, was diagnosed with Lupus in college and also diagnosed with exercise-induced urticaria and Mast Cell Activation Syndrome. She got COVID in 2021.In this “Interventions With Dave” episode, Dave examines what’s going on with Lisa’s varied symptom. They discuss what’s working and what’s not, and what can help her gain more energy and control of her health. The conversation gets into a bunch of topics, like:PMS “flu” (with sore throat, hot tongue, achy, brain fog, no energy, feverish feeling with no fever present, painful periods) Hormones, the Wiley Protocol and testosterone“Mold cough” and other symptoms of moldOCD and anxietyMTHFR gene mutation Histamine, Mast Cells and Mast Cell Activation SyndromeAllergiesAnd much more…Find biohacking tips, tools and resources particular to this episode on the episode web page: https://daveasprey.com/interventions-with-dave-lisa-b-949/Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

SPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Go to beamminerals.com/advancedset. Use code DAVE to get 20% off.IN THIS EPISODE OF THE HUMAN UPGRADE™... …you’ll find out how plant-based humic substances have the power to stop and reverse the effects of glyphosate damage in both humans and soil.Caroline Alan, co-founder and CEO of BEAM Minerals, explains how minerals provide your body systems with critical cellular support, how they get depleted and how you can replenish them. She goes even further to talk about glyphosate’s harmful effects on human health and soil health, particularly when it comes to minerals.In her former corporate career of software development and business consulting, Caroline experienced problems physically, mentally and energetically. She struggled with issues like life-long gluten intolerance, whole-body inflammation, leaky gut, chronic headaches, flat-lined adrenals and low thyroid. Her chronic health issues didn’t resolve until she began taking plant-based humic and fulvic minerals.This cellular support changed her life so dramatically, she started deep research into the science of minerals and co-founded BEAM Minerals. Then she kept going and began to look more closely at the current problems with farming in soils that have become unproductive due to a lack of microbial and mineral content. She investigated the effects of glyphosates on soils and in the human body and found:One of the root causes of unhealthy soil can be linked directly to glyphosate use in modern production farming.One of the root causes of mineral depletion and chronic illness in modern humans points directly to glyphosate ingestion.The bottom Line? We all have glyphosates in our bodies. Here's what it can do: Suppress critical enzymes, create gut dysbiosis, chelate minerals from your system, reduce mitochondrial function, and cross and affect the blood–brain barrier. Studies also show more use of glyphosate can lead to an uptick in chronic and acute health conditions.Research finds that plant-based humic and fulvic substances offset glyphosate harm. This conversation will help you recognize symptoms of mineral depletion in your own body. You’ll get practical tips about how to use 100% bioavailable, plant-based fulvic and humic mineral supplementation in easy forms like liquids and topical spray.BONUS: For research links and other resources about glyphosate and humic/fulvic substances, visit daveasprey.com/glyphosate.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Complete Spectrum Hemp + Chinese Herbs: https://radicalrootsherbs.com/DAVE, use code DAVE to get 10% offTasty Keto Bread & Chips: https://www.uprisingfood.com/DAVE, use code DAVE to get $10 off the starter bundle8th Annual Biohacking Conference: https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™... … you’ll get tips about how to lead a brain healthy lifestyle and how to keep perspective along your own entrepreneurial journey. Activism, acting and entrepreneurship are wired into Patrick Schwarzenegger’s DNA. He thoughtfully balances each passion through his work as an Alzheimer’s advocate, actor, investor and food founder. Patrick’s known for his trend-spotting abilities in the better-for-you food and beverage industry. He got into the fast-casual Blaze Pizza franchise when he was just a teen. That experience solidified his interest in health and wellness: “invest solely into entrepreneurs and companies that were providing Americans with the healthier alternative." He’s now an active investor and advisor to numerous brands and helps founders scale their emerging businesses to the next level.His latest venture encourages brain health at every age and supports programs, research, and lifestyle choices designed to make your brain work better. Patrick co-founded a new brain health food brand called “MOSH” with his mom, Maria Shriver, designed specifically to up-level your brain function.“We really want it to be a brand that was created out of a mission and out of the why, and not so much the what,” Patrick says. … “We want to be a brain health company and also educate consumers and raise money and donate that to the Women's Alzheimer's Movement. So, it's been an amazing journey.”A journey with its share of mishaps, too: “We had so many things that went wrong and that was kind of the fun part was learning about that and finding ways to fix it. That's wanting to be an entrepreneur or that's embarking on that journey, you're going to have speed bumps. You can do as much homework as you can and want and try to perfect everything before you launch, but things come out of left field every single day.”He’s on the show to discuss entrepreneurship, how to invest, how to build brands, how to hire the right people and what’s possible for high-functioning brains at every age.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!A New Peptide Builds Healthier Skin: https://www.oneskin.co, use code DAVE15 to get 15% offMinerals for Cell Function: https://www.beamminerals.com, use code DAVE20 to get 20% offUnlock Your Brain with Customized Nootropics:https://nootopia.com/dave, use code DAVE10 to save 10% on your first order See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll learn how your cells, mitochondria, immune system, sleep patterns, inflammation, nerve growth pattern, and energy levels all benefit from mushrooms. These fungi are full of compounds and nutrients that your body will love. There’s a whole lot of science behind this now.In this special podcast edition, you’ll hear how two mushroom experts are studying and harnessing the amazing powers of mushrooms for the deepest parts of human biology and the natural environment. Paul Stamets, is a speaker, author, mycologist, medical researcher and entrepreneur. He’s considered an intellectual and industry leader in habitat, medicinal use and production of fungi, and he considers himself a “mycological warrior.” He’s spent over four decades in the Pacific Northwest studying and researching the world of mushrooms. Listening to him describe, decode and illuminate the workings of the mushroom world is an enthralling experience, indeed. He says we’re intertwined with mushrooms at a cellular level. He believes that habitats have immune systems—just like people—and mushrooms are cellular bridges between the two. Our close evolutionary relationship to fungi can be the basis for novel pairings in the microbiome that lead to greater sustainability and immune enhancement. And from neurogenesis to our microbiome to our mitochondria, fungi are linked to us. He’s also making some amazing discoveries having to do with bears, bees, butterflies and biodefense.Mycelium Just Might Save the Bees, And Us – Paul Stamets – #624 Learn more at fungi.com Julian Mitchell, —co-founder and CEO of the Australian-based company Life Cykel—and his team work with mushrooms as innovative food sources and medicinals in Australia. “Mushrooms and mushroom-based foods are going to play a huge role in the future of food,” Julian explains. “They grow quickly requiring very little resources in terms of water, power, and land. They have an amazing nutritional profile, and of course, they are 100% natural.” … “Mushrooms are almost an uncharted continent, with infinite applications not just in food but in biotechnology.”For day-to-day use, you’ll want to go with cooked, not raw, mushrooms. For those of you who aren’t fans of eating mushrooms, there’s an option for you, too: “Having it as a tincture makes it very easy to add to a coffee, add to a tea, add to a smoothie,” Julian says. “It’s quite tasteless and at the same time micro-dosing it in small amounts straight into your mouth is a great way to have it as well and absorb it straight into your blood system.” Mushrooms Are Your New Anti-Aging Strategy – Life Cykel #603Learn more at lifecykel.comWE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Science-backed, Music-driven Breathwork: Go to https://www.othership.us/dave, sign up for the app and get two weeks free.Fitness Center of the Future: Check out franchise opportunities for biohackers at https://ownanupgradelabs.comKickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™... … you’ll learn why every breath you take makes a difference in how your entire body functions. The way you breathe affects the quality of your life and every one of your body systems. Full stop. This goes for adults and kids alike.In this special edition, breathing experts Patrick McKeown (“THE BREATHING CURE: Develop New Habits for a Healthier, Happier, and Longer Life”) and James Nestor (“Breath: The New Science of a Lost Art”) approach the topic from diverse perspectives, but agree on a lot. Especially the benefits of nose breathing and the detriment of mouth breathing.They explain the biochemical, biomechanics and psychological components of how you breathe. They also present exciting new research in pulmonology, psychology, biochemistry and human physiology that shows how making even slight adjustments to the way you inhale dramatically influences things like:sleep and snoringfitness and athletic performancebrain functionfocus and concentrationoxygen intakeheart rate and blood pressureblood sugarinternal organ functionnervous systemrespiratory healthasthma and allergiesautoimmune diseasesexfemale hormonespainstress and anxiety That's just the start of what you can change when you change your breathing. Big claims, yes. All true. And even bigger benefits for you.Breathing can nurture your body, center you, and rebalance you. When you start harnessing the power of your breath, you're going to feel incredibly better than you do right now. Patrick McKeown, an author, educator and one of the world’s leading breathing re-education experts, has researched breathing for more than two decades. Listen to more: Shut Your Mouth! Nose Breathing Improves All Your Body Systems – Patrick McKeown – #835James Nestor, a San Francisco-based science journalist, author, surfer, free diver, adventurer, and speaker, set out on a decade-long quest to find out where our breathing went wrong—and how to fix it. Listen to more: Breathing Essentials That Will Change Your Life – James Nestor – #751WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Support Your Body’s Natural Repair Mechanisms: https://eng3corp.com/DAVE/Must-Have Magnesium: https://magbreakthrough.com/DAVE, use code DAVE10 to get a 10% discountMeat Sticks! All the Good Stuff-No BS: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

SPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Go to https://www.oneskin.co and use code DAVE15 to get 15% off your first-time purchase.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you’re listening to a new Upgrade Spotlight series based on what you told me you wanted to hear on this podcast. On one Friday each month, these shorter episodes will feature guests who’ll get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. Introducing OneSkin! During this Upgrade Spotlight, you’ll learn about new products designed to target skin aging at the molecular level and promote skin and body health. You’ll also find out the science behind OneSkin’s formulas and why they are considered “daily topical supplements.” They can help you maintain functional and resilient skin as you age. OneSkin topical supplements are powered by a proprietary peptide: OS-01, which decreases the accumulation of aged/senescent (zombie) cells in the skin. By targeting the major driver of skin aging, OS-01 has been scientifically proven to:• Repair cellular damage, including UV damage• Increase epidermal thickness• Improve barrier function• Increase the activity of genes associated with collagen, hyaluronic acid, and elastin production• Reverse the biological age of skin“So this peptide has a very interesting profile because it's small enough to penetrate and it's super safe,” explains Carolina Reis Oliveira, Ph.D., scientist, CEO and co-founder of OneSkin. “There is no toxicity, no irritation. We've done all the recommended studies by FDA for personal care products, and, has this beautiful effect of reducing the accumulation of senescent cells, and also reduces the release of inflammatory markers, and increase the production of hyaluronic acid, elastin and collagen. So, in the end, there's a molecule that has all these attributes that's very important for healthy skin, overall.”Another exciting part of this peptide work includes MolClock, the first skin-specific molecular clock, capable of reliably and accurately determining the biological age of skin. This was created by OneSkin’s team of female PhD-level longevity scientists as part of its research and development platform.Carolina relocated from Latin America to Silicon Valley in 2016 to co-found OneSkin and lead the development of the company’s disruptive skin rejuvenation technologies. She holds a Ph.D. in Immunology, along with degrees in biochemistry, stem cell biology and tissue engineering. Her team of co-founders includes three other female scientists with additional expertise in skin regeneration, bioinformatics, genomics, immunology and molecular biology. Among them, they’ve invented numerous patents and have published nearly 100 peer-reviewed papers in scientific journals.This episode explores exciting new information about improving skin health at the molecular level for the long-term. When you do that, your body will be more equipped to defend itself from environmental stressors and aggressors, especially with age. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Capture Life Force Energy: https://leelaq.com, use discount code DAVE10 to get 10% off sitewideSkin Health and Healing: https://alituranaturals.com/shop/, use code DAVE20 for 20% off storewideBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Go to https://pendulumlife.com and use promo code "DAVEVIP" to get an exclusive discount.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll learn about emerging science that points to the effects of sugar on your gut microbiome and metabolism and the connections between sugar, your mental acuity and longevity.Biochemist and molecular biologist Colleen Cutcliffe, Ph.D., continually searches for new ways to improve your gut health and help you live longer. As CEO and co-founder of Pendulum Therapeutics, she works to turn scientific discoveries into real products that hack and heal your microbiome and its associated body systems. At Pendulum, her team identifies and isolates new bacterial strains then combines those new strains to create unique probiotics.“We really worked hard on ways to modulate post-postprandial glucose spikes through the microbiome,” Colleen says. The result? Pendulum’s Glucose Control lowers blood glucose spikes by 33 to 34% for people with type 2 diabetes. “What we didn't realize was how many people who don't have type 2 diabetes were going to end up benefiting from it.”This conversation homes in on sugar management and a broad range of research that’s exploring what you can do about managing your glucose to keep up your mental acuity (less brain fog, sharper thinking) and live a longer life. Science has discovered that as you age:You have reduced ability to metabolize sugar. Your microbiomes become less diverse and depleted of certain key strains that are important for sugar metabolism.If you improve glucose control, you see reduced neuronal inflammation and improved cognition.In the past decade, especially, sugar dominates a lot of the conversation around diet and health. It’s been studied, substituted, moderated, restricted and demonized. With that type of focus, you lose the bigger point.  “You can't completely cut out sugar,” Colleen says. “You do need sugar. Not all sugar is bad for you all the time. Every cell in your body, except for your colon cells, need glucose in order to survive, in order to replicate, in order to perform functions. All of the things that allow you to be a human being require some amount of sugar."She wants you to know what’s happening to cause the change in metabolic processing as you age and what you can do about it, like:How to understand your blood glucose range and what fluctuations mean.How to track your blood glucose and what to do about peaks and dips.How to improve your focus, sharpness and mental endurance through diet and fitness.“I'm a scientist, so I'm always going to say more data is better,” Colleen explains. “[Especially] when you're trying to make improvements and you're making these micro-adjustments in your life, and you want to understand what impact are they having.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Hydrate with Electrolytes: https://DrinkLMNT.com/DAVE, get a free LMNT Sample Pack with 8 single-serving packets for the cost of shipping ($5 for U.S. customers) Control Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentMattress Temperature Tech: https://www.eightsleep.com/dave, use code DAVE to save $250 on the Pod ProIN THIS EPISODE OF THE HUMAN UPGRADE™... …you’ll learn how to connect the principles of self-coaching to biohacking. You may already be doing some things, but this topic will help you fine-tune your approach in simple, yet powerful, ways.High performers typically know the value of coaches: experts who can train them and guide them toward goals. But what if you could become your own coach? Podcast guest Jason Goldsmith emphasizes the value of combining the mental and physical aspects of human performance. He knows, too, that it’s important to learn to coach yourself to achieve any kind of life success you go after. Self-coaching doesn't mean you do it all on your own, it means that you take charge of yourself, for yourself.This episode brings these concepts together so you can be in charge of yourself and be confident and purposeful when making decisions. A globally recognized performance coach and founder of Goldsmith Performance, Jason’s best known for his work with golfers, from junior, to amateur to professional skill levels. He also coaches athletes from other major sports, as well as Fortune 500 executives.He’s distilled his knowledge and partnered with David Novak, cofounder & former CEO and Chairman of Yum! Brands (owner of 45,000+ restaurants) to present sports and business coaching for high performance. They’ve created a practical guidebook for you to learn how to be your own best coach: “Take Charge Of You: How Self Coaching Can Transform Your Life and Career.”This conversation covers strategies to develop an understanding of who you are and what drives you. “That is a crucial part of choosing your SBT (single biggest thing): it should feel big, important, impactful, even aspirational,” Jason says in his book. “There is a difference between setting a goal and choosing a destination.”You can outline a process with that knowledge that sets you up for success. And then add in something you may not have considered: “Joy is a critical ingredient, and I don't think enough people have enough joy in their day-to-day life,” Jason says. “It’s really important for people to know what it is that brings them joy and what are the things that diminish their joy. So, if I was able to biohack my day, what are the things I do every single day that make me feel the best possible version of myself? But then what are the things that get in the way of that joy? And then how do I eliminate those joy blockers and have more of those joy builders?”You’ll find out how in this episode! “Take Charge of You” includes do-it-yourself lessons, stories, tips, and questions to ask yourself to track your personal growth and professional development. You can follow this blueprint for self-coaching, no matter what your goals may be.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.Drugs that cut down cancer risk by 61% aren't really drugs.Take the right type of Vitamin D for the most benefit.Stressing cells in the sauna could help reverse neurological disease.A new discovery in brain communication and function.Making stem cells younger in less time.Active brown fat could be a marker for pre-diabetes.EPISODE SPONSOR: Infrared Sauna Benefits with Sunlighten. https://www.sunlighten.com/DAVE. Save up to $600 on your sauna purchase! Mention code "DaveAsprey" for discount.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Skin Health & Healing: https://alituranaturals.com/shop/, use code DAVE20 for 20% off storewideDigestion & Immune Function: https://justthrivehealth.com, use code ASPREY to get 15% offBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationIN THIS EPISODE OF THE HUMAN UPGRADE™... …you’ll learn how biological age, rather than chronological age, is the primary risk factor behind diseases like cancer, heart disease, diabetes, strokes, even Alzheimer’s. Scientific discoveries show chronological aging may be written in the epigenome, those chemical tags attached to your DNA that control the way DNA operates.We’re finding out more about both types of aging because of scientists like Morgan Levine, Ph.D., a leading voice in the field of aging and longevity science. She focuses her research on the science of biological aging, emphasizing health span over lifespan. “If you take the difference between someone’s biological age and chronological age, it should predict the things we care about, the actual things we're trying to prevent—so death, disease,” she says. She’s an assistant professor of pathology and the Director of the Laboratory for Aging in Living Systems at Yale University School of Medicine. Her team looks at using bioinformatics to quantify the aging process and test how lifestyle and pharmaceuticals alter the rate of aging. She’s also a founding Principal Investigator at Altos Labs, a biotech company that focuses on cellular rejuvenation programming to restore cell health and resilience.Today, she’s going to talk about the science of aging and longevity explored in her new book, “True Age: “Cutting-Edge Research to Help Turn Back the Clock.” Three main drivers—health behaviors, recent stressors and adversity, and genetics—determine your biological aging. She shares how to measure your own biological age and why you should track your aging regularly. This conversation gets into topics and makes them make sense for your own aging, like:Epigenetics & epigenetic clocksDNA methylation & telomeresCell lifespan Ageotypes (molecular assessment of aging)Phenotypic ageThe “Ceiling” effectThe “CALERIE” trialNutrition & aging (plants, fasting, ketosis)Fitness & aging (energy & brain health)Rest & relaxation (sleep & biological programming)Morgan gives great takeaways on how you can make lifestyle changes to maintain your youthfulness—both inside and out—with low-risk, data-driven biohacking. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Trigger Autophagy: https://spermidinelife.us/dave, use code DAVE25 for 25% off your first month’s orderMeat Sticks! All the Good Stuff-No BS: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderSleep Better on Natural Memory Foam: https://myessentia.com, use code DAVEVIP to get an exclusive discountIN THIS EPISODE OF THE HUMAN UPGRADE™...…you’re going to find out why you’re missing 50% of your life to fractured attention and distraction and what it’s doing to your brain. Podcast guest Amishi Jha, Ph.D., a neuroscientist and professor of psychology at the University of Miami, researches how people pay attention. She co-founded the Contemplative Neuroscience for the Mindfulness Research and Practice Initiative at the University of Miami and serves as its director. For more than 25 years, she’s researched the science of attention through intensive work with the U.S. Military, first responders, medical professionals, business leaders, and elite sports teams.She’s found that attention Is both your superpower and your kryptonite. As a superpower, attention allows you to time-travel in your mind (future and past), highlights what’s important, helps you problem solve, and shuts out distractions, she explains in her book, “Peak Mind: Find Your Focus, Own your Attention, Invest 12 Minutes a Day.” When attention is compromised, it’s your kryptonite because it impacts your cognitive function, social engagement, and emotional balance, she points out. The three main forces that degrade attention include, 1) the amount of stress you’re under (and how you’re managing it); 2) being in a crappy mood; and 3) threats real or imagined.And when your attention gets fractured, you often default to tactics that fail to pull it back together. Amishi’s got great insights in her book that allow you to understand why this happening. When you know what’s going on, it's easier to find your focus.It’s absolutely possible to change your brain to become more attentive, present, and productive through mindful techniques and daily focusing practices. Amishi’s research shows that mindfulness gives you a sense of control over your mind and allows you to stop negative thinking before it hijacks your brain and body.The type of mindfulness practice you choose isn’t as important as how consistently you actually do it. The minimum effective dose equals 12 minutes a day, five days a week.Listen on to a conversation that gives you practical tips on how to re-capture your attention, train your brain and perform at your peak.More about Amishi Jha, Ph.D.: Amishi earned a Bachelor of Science degree in Biological Psychology then went on to earn a Ph.D. in Psychology (Cognitive Neuroscience) from the University of California–Davis. She completed post-doctoral training at the Brain Imaging and Analysis Center at Duke University in functional neuroimaging. She leads research on the neural bases of attention and the effects of mindfulness-based training programs on cognition, emotion, resilience, and performance. Her work has been featured at NATO, the World Economic Forum, and the U.S. Pentagon. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Episode of The Human Upgrade™...​… Dave talks with Sean Plotkin about changing up his current biohacking routine to get even better results. You’ll find out how to maintain a high quality of life amid the “hustle” that can take up a lot of your everyday life.In his mid-40s, Sean’s doing a lot to improve his energy, keep his body strong and stay ahead of aging. But, he says, the weight keeps creeping up and he’s concerned about his thyroid function. He has an intense weekly exercise routine and could use some help with nutrition before and after his fitness sessions. He also wants to tackle sleep, believing his isn’t as optimal as it could be.He’s doing a lot of things right, including: supplementing with glutathione, using ozone, wearing a continuous glucose monitor, cooling his sleep with an Ooler Sleep System, tackling how he feels with Hapbee, managing stress and performance with NuCalm, upgrading his brain at 40 Years of Zen, and investing in a hyperbaric chamber and sauna for home use. In this “Interventions With Dave” episode, Dave examines what Sean’s doing, what’s working or not, and what he can do to reach his peak performance consistently. They break down:Nutrient availability (No. 1, energy; No. 2, protein; and No. 3, carbs)Blood glucose and insulin resistanceCortisol and stressHormonesCognitive functionNutritionPre-diabetesFatty liverInflammationCold therapyCholesterolMetabolic healthBrain healthAnd much more!Sean’s already got great awareness, tools and data to work with. Along any journey, it takes some experimentation—and time—to find that sweet spot that makes you feel like a million bucks. Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.Don't miss the previous episodes in the Interventions With Dave series:Hacking Weight Loss Resistance #930Hacking Thyroid, Autoimmunity & Aging #918Hacking Inflammation #915Hacking Your Gut Microbiome #908Hacking Menopausal Weight Gain #904Hacking Eyesight #895See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Nature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% offNAD+ for Brain Health: https://innovativemedicine.com/DAVE and save 20%Minerals for Cell Function: https://www.beamminerals.com, use code DAVE20 to get 20% offSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.radicalrootsherbs.com/, use code “DAVE15” to save 15% off Radical Roots full-spectrum hemp and Chinese herbs products.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll learn about all things CBD, hemp and THC: what current research says, why quality matters, and how to get real results. Paired with particular Chinese herbs, the benefits to you increase even more.In the last few years, CBD was a trend, then the market got saturated, and then people said: “I tried CBD and nothing happened.” That’s unfortunate, because experts like acupuncturist, herbalist and Chinese Medicine practitioner Dr. Chloe Weber know exactly what works—and how. There are four main ways hemp supports the mind and body, and this conversation gets into the mechanisms of them all: Anxiety and stress, GI support, immune support, and pain management/inflammatory disorders.You’ll also find out:The differences between full spectrum (with 0.3% THC) vs. isolate vs. pharmaceutical cannabis.How your body’s endocannabinoid system works and why it’s your master regulator.What endocannabinoid deficiency means for your body.How to take CBD and how long it takes to experience its effects.How pairing CBD with Chinese herbs can benefit your body and brain, and power your performance.What to look for in high-quality hemp products.How to maneuver through cannabis strains and THC potencies.How to decide between CBD oils, capsules, topicals for your particular health needs.Common misconceptions about and censorship of CBD.What new cannabinoids are coming onto the scene, like CBG and CBN.Chloe founded Radical Roots Herbs, a company that offers full-spectrum hemp product and also combines CBD with Chinese herbs to boost the power of both.“By calming the nervous system and supporting our endocannabinoid system,” Chloe says, “we're actually able accept, absorb and process the Chinese herbs in a more dynamic way."See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Support Skin Health and Healing: https://alituranaturals.com/shop/, use code DAVE20 for 20% off storewideSupport Digestion and Immune Function: https://justthrivehealth.com, use code ASPREY to get 15% offSupport Your Body’s Natural Repair Mechanisms: https://eng3corp.com/DAVE/IN THIS EPISODE OF THE HUMAN UPGRADE™...… I will teach you everything you would ever want to know about before surgery, during surgery and after surgery, so that you come in strong, you have a better surgical experience, and you recover way faster than you're supposed to. Research shows that if you live in America, you’re likely to have an average of seven surgeries in your lifetime. Wouldn’t you want to know how to go in at your best so you can recover at your best? This was my thinking when I went under the knife last year. In the hours and days that followed, I blew my doctor’s mind. He had never seen a recovery like mine. As the Father of Biohacking, I never shy away from an opportunity to blow the lid off what we think is biologically possible. And then I share what I’ve found with the world.In Heal with Dave, my new documentary, you’re going to learn all of the methods I used to heal without pain and recover to the fullest and beyond. I’ll teach you how.If this sounds interesting to you and you want to know what to do to have control of your biology at a time when frankly, a lot of people take quite a while to recover and there's increased risk of all kinds of bad things like infections, systemic issues, just not healing very well and building strong tissues, go to daveaspery.com/heal. Watch the documentary, use the resources. It's my gift to you! “Heal with Dave” Documentary: https://daveasprey.com/heal/Ali Sadrieh, DPM at Evo Foot: https://www.evofoot.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Control Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentTasty Keto Bread & Chips: https://www.uprisingfood.com/DAVE, use code DAVE to get $10 off the starter bundleBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationIN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll learn why developing your attributes may be more important than skills when it comes to getting more out of yourself. Attributes are wired into your internal circuitry, always running in the background, says Rich Diviney. You’re born with attributes. They’re elemental and considered innate traits—not to be confused with personality traits.Rich, a retired Navy SEAL commander, bestselling author, and leadership and human performance expert, explains how attributes determine how you absorb, process, and respond to the world around you. By knowing this, you’ll be able to assess your own attributes and put them into action with SMART steps.In his book, “The Attributes: 25 Hidden Drivers of Optimal Performance,” Rich shows you how mindset, optimism and becoming uniquely resilient to stress can help you become a better human. His approach identifies core attributes needed for success in personal or professional tasks.His ability to choose the right people to be in elite performance groups—like the U.S. Navy SEALs—could be considered a superpower. As the officer in charge of training for a specialized command, Rich was part of the SEAL selection process. He pared down a group of exceptional candidates to a small cadre of the most elite optimal performers. How did he do it? By looking at attributes.It’s Rich's belief that SEALs are not born extraordinary. Instead, they’ve mastered their own mindset to get the most out of their innate abilities to make themselves extraordinary. He believes we all have the power to do this.In “The Attributes,” you’ll find examples of attributes within five distinct categories plus a couple more that don’t fit so neatly: Grit, Mental Acuity, Drive, Leadership and Teamability. So, what are attributes and how are they different than skills? “A lot of times we get seduced by skills, and we don't think about attributes,” Rich says. “And the reason is very simple: skills are not inherent to our nature. They're very visible, which means they're very easy to assess, measure and test and you can put scores around them and stats around them. … Attributes are inherent to our nature. We're all born with levels of adaptability and situational awareness and resilience.  Attributes don't dictate our behavior or director behavior; they inform our behavior.” See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Track Blood Glucose: https://www.levelshealth.com/DAVE, sign up for the Beta groupKickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planMattress Temperature Tech: https://www.eightsleep.com/dave, use code DAVE to save $250 on the Pod ProIN THIS EPISODE OF THE HUMAN UPGRADE™... …you’ll learn that to be a high performer, you’ve got to have radical confidence to achieve whatever goals you set for yourself. Today’s guest, Lisa Bilyeu, explains how real confidence is an inside job, not something you gain from outside validation. When Lisa co-founded Quest Nutrition, she was a self-professed housewife boxing protein bars in her living room. The company grew 57,000 percent in its first three years and became a billion-dollar brand. Her learning curve was steep and fast and filled with things she didn’t know how to do—yet. She went on to co-found (with her husband, Tom Bilyeu) and serve as president of Impact Theory Studios. It’s a digital-first studio that produces entertaining original content focusing on themes of empowerment. That content has been viewed over half a billion times by a global audience.Lisa oversees in-house development of projects focused on female-driven content for multiple platforms. She hosts the digital series, “Women of Impact.”In her first book, “Radical Confidence: 10 No BS Lessons on Becoming the Hero of Your Own Life,” she shares her journey from a housewife to successful entrepreneur with relatable lessons, anecdotes, and lots of humor.She explains how the “Purgatory of the Mundane” is even more dangerous than hitting rock bottom. She dishes tough love for those of you who are stuck in mind loops that hold you back.From ditching the fairy tale to getting off the couch to putting on goggles when the shit hits the fan, Lisa’s got realistic tips to get you moving. An important part of that momentum is setting boundaries: material, physical, and mental and emotional. She shows you exactly how.She also suggests a fresh perspective on a few things that can help you build “radical” confidence:Manage the voice in your headSet clear boundariesLearn from your mistakesKeep your goals top of mindMaintain self-awareness around your emotions and triggersSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™... …you’re listening to a new Upgrade Spotlight series based on what you told me you wanted to hear on this podcast. On one Friday each month, these shorter episodes will feature guests who’ll get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. Introducing Xero Shoes! During this Upgrade Spotlight, you’ll learn how minimalist footwear reduces injury, improves foot strength and supports healthy feet. You’ll learn that getting grounded is a good thing.Today’s guest—serial entrepreneur Steven Sashen—is a competitive sprinter. He knows the mechanics of human feet. He also knows what it feels like to move in shoes that suck. So, he and his wife, Lena Phoenix, founded the footwear company Xero Shoes. They ran headlong into shoe history and shoe science to intentionally create “a MOVEMENT movement” of people with happy, healthy, strong feet in addictively comfortable footwear. “A quarter of the bones and joints of your whole body are in your feet and ankles,” Steven says. “They're supposed to bend and move and flex just like any other joint. If you're wearing shoes that don't let them do that, that function tries unsuccessfully to move into your ankle, your knee, your hip and your back joints. Those joints aren't built for those micro motions that keep you balanced, that give you agility and mobility.”Your feet, and by design the rest of your body, know something’s off with cushioned shoes. So does Steven.“The value of natural movement, the importance of foot health, and all the things that relate to foot health got me going,” he says. “But what really catalyzed it was discovering that what the footwear industry has been doing for 50 years is lying to people– selling people on ideas that they know don't work, but they can't pull back. They can't tell a different story, because they've been promoting this story for so long about arch support, motion control, padding, cushioning, etc.” Research published by the American College of Sports Medicine in 2021, “Stepping Back to Minimal Footwear: Applications Across the Lifespan," showed that minimal footwear leads to improved musculoskeletal health across your lifetime. “It’s all about natural motion,” Steven explains. “Our ancestors didn't have a problem being on their feet all day, every day. It wasn't because they're different from us, it was just that they got used to using their feet correctly. We can still do that any day, anytime, any of age.”CHECK OUT XERO SHOES and the 5,000-MILE SOLE WARRANTY! U.S.: https://xeroshoes.com and EU: https://xeroshoes.euSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Complete Spectrum Hemp + Chinese Herbs: https://radicalrootsherbs.com/DAVE, use code DAVE to get 10% off Meat Sticks, Apple Cider Vinegar and More Good Stuff: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderBiostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale BusterIN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll find out why you’re tired, how to fix it and ways to increase your energy. Fatigue is a hidden epidemic, with chronic fatigue syndrome being the most severe end, but most people (in the U.S.) are experiencing some level of being flat-out tired as hell.Guest Ari Whitten, Ph.D. (Cand.), CES, PES, says that as a culture, we have normalized fatigue. In his newest book, “EAT FOR ENERGY: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energy,” he explains that 5.4 million adults in the U.S. have been diagnosed with chronic fatigue syndrome (the most severe case of fatigue). However, the true fatigue epidemic affects 50 to 100 times more people.This episode’s discussion gets right into the role of mitochondria in human energy. Ari’s research (420 citations in “Eat for Energy”!] is clear. The cause of fatigue is mitochondrial dysfunction, he says. And the biggest factors that affect your mitochondria include:Circadian rhythm dysregulation and poor sleep Carrying too much body fat and too little muscle mass Poor gut and microbiome health Blood sugar dysregulation Nutritional toxicities and deficiencies Neurotransmitter and hormone imbalances So what can you do to increase your energy currency? A lot, as it turns out. When you understand factors like resilience, cell defense, nutrition and supplementation, you’re on your way to better energy. In this conversation, you’ll learn:what’s causing the dysfunction in your mitochondria and how you can repair these critical energy cells. strategies that will double your energy levels. 7 top supplements (and more) that help get your mitochondria back on the energy track. Ari has been studying and teaching natural health science for more than 25 years. He went through his own battle with chronic fatigue that inspired his obsession with energy. For the past seven years, he's focused specifically on improving human energy. His education and work in this area touches on critical aspects of human health from nutrition to physical training, to light science, to psychology, and more. He created The Energy Blueprint science-based lifestyle programs that target brain energy and mitochondria. He also hosts The Energy Blueprint podcast that features world-wide experts on the subject of understanding fatigue and how to get more energy. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Sleep Better on Natural Memory Foam: https://myessentia.com, use code DAVEVIP to get an exclusive discountMust-Have Magnesium: https://magbreakthrough.com/DAVE, use code DAVE10 to get a 10% discountControl Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentIN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll meet a holistic neurosurgeon who’s evolving spine care away from cutting. Dr. Marcella Madera’s integrative approaches to spine problems pair science with holistic healing modalities. This means way better healing for you.Dr. Madera’s innovations in spine treatments include the “Aqua Method,” where photobiomodulated platelet rich plasma meets functional tissue mobilization and movement. You’re going to get exciting new information about this effective form of regenerative medicine and find out if this treatment may be right for you. “It's a very nuanced discussion,” says Dr. Madera. “It's very patient specific. It's very injury specific.”“The term Aqua really gives a description of what we're trying to create in the body and that is more fluidity,” she explains. “And also, water, aqua, is pure. It’s intense at times, depending on the form. And it is soothing at times, depending on the form. And that is how our treatment goes.”Dr. Madera’s four-part system includes: Reveal, Restore, Revitalize, Revel. You could benefit whether you have an old or new injury, or chronic pain.During this episode, she explains how each part is interconnected and helps you heal your spine, or even knee, problems. The Aqua Method’s three-day immersive experience includes a full team of experts focused on your biology, your energy and your state of mind.Dr. Madera, a board-certified neurosurgeon, trained extensively in conventional medicine. Her expertise in spine care includes surgical treatments, approaches, and techniques for degenerative spine disease, spine tumors, and degenerative deformity. She started a private practice in in Austin, Texas where she combines her technical spine care with stem cell treatments and holistic modalities like herbs, energy modalities, Chinese healing practices, autogenic training and diet modification.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Get a $1,000 discount on the Aqua Method at Austin Integrative Spine in Austin, Texas. Call the clinic at 512-817-4600 and mention discount code DAVEASPREY.More about Dr. Marcella Madera: She’s experienced in open surgery, minimally invasive surgery, endoscopic spine surgery, and regenerative/stem cell procedures. She’s been an assistant professor of Surgery at the University of Texas at Austin Dell Medical School. She also travelled throughout Europe and the U.S. to learn progressive endoscopic techniques and regenerative medicine practices. She completed a Spine Fellowship and faculty instructorship at Johns Hopkins School of Medicine.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.GlyNAC (glycine and N-acetylcysteine) can correct glutathione deficiency, oxidative stress, mitochondrial dysfunction and mitophagy abnormalities to help you live longer.Moms and dads think — and react — differently to newborn baby smells.Clock and Cycle factors control circadian rhythm and protect your eyes as you age. Oleic acid produced in the brain helps regulate memory, learning, and mood; promotes neurogenesis; and increases cell proliferation.EPISODE SPONSOR: The Eng3 NanoVi device helps repair oxidative stress damage and support the body’s natural repair mechanisms. https://eng3corp.com/DAVE/. Learn more: The Anti-Aging Science Behind the NanoVi Device – Rowena Gates & Hans Eng – #416.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Nature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% offNAD+ for Brain Health: https://innovativemedicine.com/DAVE and save 20%Support Immune & Digestive Health: https://justthrivehealth.com, use code ASPREY to get 15% offIN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll learn that one of the major life upgrades you can make includes your relationships. Personal development expert Gary John Bishop doesn’t buy into mainstream notions of what makes a happy relationship. Not 50/50 effort, not compromise, not molding yourself into what your partner wants. It’s just you and some hard truths.What this episode is not about;Blame or providing communication tipsHow to change or cope with your partner and personality types Healing past trauma or understanding fear of commitment Instead, you’ll get the ingredients to creating a real, lasting and profound connection with another human being.“There's some, again, cold truths that you have to face and then really have to start to take on,” he says, “but in a way that it's not always going to go your way. You're not always going to get this thing flowing the way you would want it to go, but your job is to keep bringing yourself to this phenomenon in a way that's consistent with you, who you are, what you're about. And powerfully managing all that you might do to undermine it.”Gary, the New York Times bestselling author of the Unfu*k book series, uses an “urban philosophy” approach that’s both simple and enlightening. In his latest book, “LOVE UNFU*kED Getting Your Relationship Sh!t Together,” he puts the focus on relationships. “The quality of your relationships dictates the quality of your life,” he says in “LOVE UNFU*kED.” This conversation gets right to the heart of what you can do to make changes that stick in all areas of your life.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Gifts for Mother’s Day – or Any Day: Give the sensation of a hug, deep relaxation and better sleep: https://balooliving.com/dave, use code DAVE for a special discountHealth Upgrades with Custom Lab Testing and Your Own Data: https://get-base.com/DAVE, use code DAVE to get 20% off your first month of membershipMeat Sticks, Apple Cider Vinegar and More Good Stuff: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderIN THIS EPISODE OF THE HUMAN UPGRADE™...You’ll be part of a candid conversation about choice and freedom. And, why it’s important to be able to make a living in your chosen line of work without restriction or judgment. That’s just part of being a better-performing human.Guest Allie Rae, a wife, mother, retired nurse and Navy veteran, shares her unusual entrepreneurial journey within the adult sex entertainment industry. It may be a different topic than you expect on this show, but it’s a look at innovation opening up alternative ways of doing business outside restrictive Big Tech.She’s CEO of a brand-new online adult platform called WetSpace. You may have heard about or know of the OnlyFans platform. WetSpace is similar, but not direct competition. Allie Rae saw a problem with payment systems and banking restrictions and set out to find a solution.“At this point, this is no longer a hobby, it's a business for me,” Allie Says. “And as any business in any industry, you want to protect your business and provide stability and have long-term prosperity.”We get into some cool topics:Why Allie Rae created WetSpace;How cryptocurrency fits into her plans;The influence of Big Tech; andHow advocacy—not regulation—can guide the growth of the adult sex industry.Today’s show looks at personal choice and freedom—both yours and other people’s. It challenges stigma, advocates for better systems of work, and supports creativity and business acumen.it's important that we think about both sex, because that's one of those big things that nourishes us, and also think about what's going on in the world around us, that environment that controls your biology.It matters that you’re able to choose what to do to and with your body, your energy, and your time. You get to choose to live your values—and so does everyone else. Even if you don’t agree. Being kind and respectful goes a long way in creating communities that allow you to be the highest performing human you want to be.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...… Dave talks with Diane Closser about weight loss resistance. You’ll find out how unexpected and insidious factors–both internal and external–may be affecting your body systems. That dysregulation can cause your body to hold onto excess weight. Diane Closser knows a lot about chemicals. She’s a chemist by profession and works as a Certified Lubrication Specialist and Certified Reliability Leader at a Division of General Motors.She also has a personal history of mold and heavy metal exposure, e.g., bought fixer-upper 1972 house, played with Mercury as a kid, worked as a wet bench chemist analyzing heavy metal production products, and worked in tire industry.She’s been on a journey to wellness for several years that’s included a search for real health solutions. There have been some wins: In 2020, she became particularly sensitive to chemicals, perfume, and laundry detergent. She says that ozone therapy cured her of her sensitivity and reversed her autoimmunity. And some setbacks: Her health deteriorated when husband was diagnosed with a brain tumor in 2011.She also had her house treated with Chlorine dioxide; did low-dose allergen therapy and low-dose immunotherapy; and completed chelation therapy. Through it all, she’s experienced a frustrating weight loss resistance. She says she’s “been on every diet and med known to man” since her teenage years. Now in her mid-50s, she’s looking forward to a retirement that includes sailing and bringing tap, jazz, and ballet classes to senior citizens around the country. She wants to improve her health and have the energy to make her plans a reality.In this “Interventions With Dave” episode, Dave and Diane look at her health concerns through a new lens. They examine possible causes of her inability to shed excess weight and discuss actionable next steps. Calorie counting Eating too little Environmental toxinsChemical sensitivitiesMold OzoneHistamineMast cellsMetal toxicity and chelation therapyBrain fogThyroidTestosterone in femalesMycotoxinsDetox pathwaysCollagenNote: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.Listen to the Interventions With Dave series and don’t miss the “Links & Resources” section below for specific information. Hacking Thyroid, Autoimmunity & Aging #918Hacking Inflammation #915Hacking Your Gut Microbiome #908Hacking Menopausal Weight Gain #904Hacking Eyesight #895See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Get Grounded with Better Foot Function: https://www.vivobarefoot.com/us/daveasprey, use code ASPREY20 to get 20% off your first order and access to the VHealth Barefoot Movement online coursesMattress Temperature Tech: https://www.eightsleep.com/dave, use code DAVE to save $250 on the Pod ProIsometrics for Cardiovascular Health: https://www.zona.com, use code DAVE2022 to get $150 off the Zona PlusIN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll learn how a trainer of superheroes and superstars combines core principles of fitness, nutrition, structure and balance.Magnus Lygdbäck, a Swedish health and wellness expert, entrepreneur, and lifestyle coach, joins the show to discuss powering your life in ways that most benefit your health and energy.For more than 20 years, he’s trained some of the world’s most recognizable actors, musicians, athletes, artists, and high-performance business entrepreneurs.Musicians like pop stars Katy Perry, Dua Lipa, Harry Styles and Britney Spears. Actors like Gal Gadot for Wonder Woman 1984; Alicia Vikander, for Tomb Raider; Ben Affleck, for Justice League; and many more.He designed Alexander Skarsgård’s incredible transformation for the lead role as a Viking Berserker in the brand new movie, The Northman. Even with his “celebrity trainer” title (which he doesn’t love), Magnus is quick to say, “It's not who you train, it's howyou train.”His Magnus Method training philosophy embraces the “ethos of an athlete.” This all-inclusive approach to performance includes an athlete’s intensity and structure, while also maintaining balance and energy. Time-zone travel, long days of filming, rehearsals, and the constant demands on a celebrity performer’s time means examining all aspects of fueling, rest and recovery. The same applies to the everyday lives of mere mortals.He encourages being open to learning new things and seeking out discomfort so you can grow. “Look at three things,” Magnus recommends. “One, what do I like to do? No. 2, what does my body need? No. 3, what do I want to master or get better at? That should create your weekly programming.”You already know, and Magnus will remind you, that there are absolutely no life shortcuts to being the superhero of your own life.In this conversation, you’ll find out how much time to spend on your workouts (not as much as you think). “What doesn’t happen in the first hour will not happen in the second,” he says frequently. Even for superheroes.Learn more about Magnus Lygdbäck’s journey from hockey player to celebrity trainer.Find out how you can improve your own performance on Magnus’s extensive YouTube channel.Get Magnus’ superhero training programs, nutrition guides, coaching and a community of like-minded people with the Magnus Method app. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Support Immune & Digestive Health: https://justthrivehealth.com, use code ASPREY to get 15% offMeat Sticks and More: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderTrigger Autophagy: https://spermidinelife.us/dave, use code DAVE25 for 25% off your first month’s orderSPECIAL OFFER FOR BULLETPROOF RADIO LISTENERS: Go to https://justthrivehealth.com. You’ll find their new line, Joot, and their new Just Calm probiotic for stress management and mood support. Just Calm features the proprietary “psychobiotic” strain BL 1714™ combined with brain-nourishing B vitamins. You’ll also find other products that tackle gut health and inflammation. Use code ASPREY to get a 15% off discount.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll learn about a strain of probiotics called psychobiotics. This strain shows promising effects on stress relief, anxiety, mood, sleep and other important gut-brain axis connections.Microbiologist Kiran Krishnan, Ph.D., explores the human microbiome and how it functions so you can have better gut health. He has an extensive research background in the fields of molecular medicine and microbiology. His particular expertise lies in gut commensal spore bacteria microbiology.He’s been a guest on the show before to educate listeners about probiotics and the connections between your microbiome, inflammation and immune function. This time, he’s sharing exciting research about a probiotic strain that’s tackling the gut-brain axis, called Bifidobacterium longum 1714™.Kiran says, “One really important message that I want people to really wrap their heads around and understand when we're talking about the gut-brain axis is, of course, the gut. A healthy gut is incredibly supportive to the brain. It supports the brain in a number of really important critical functions like recovery, for example, or production of serotonin and dopamine and all these important neurotransmitters, but on the other end of the spectrum, an unhealthy gut is not only not supportive, but it's arguably one of the most toxic things for the brain.”Big topics covered in this episode include:Basic mechanisms by which the gut microbiome can influence neurochemicals and brain inflammationThe gut-brain connection as it relates to stress coping and mental healthHow cortisol and interleukin 6 drive stress response and inflammation in your whole bodyVariables that can cause a breakdown or dysfunction in the psychobiomeTherapeutic interventions, including psychobiotics that can help correct gut-brain axis dysfunctionKiran’s great at explaining the science so you clearly understand what the studies mean and can apply new knowledge to your own biology. He also partners with Just Thrive Health on product research and development.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Mattress Temperature Tech: https://www.eightsleep.com/dave, use code DAVE to save $250 on the Pod ProHealth Upgrades with Custom Lab Testing and Your Data: https://get-base.com/DAVE, use code DAVE to get 20% off your first month of membershipVascular System Protection: https://arterosil.com/DAVE/, save up to 45% a 3-pack to protect your blood vessels from vulnerable plaque.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll learn how nature, human health, and climate activism interconnect. Emma Loewe, environmental journalist and senior sustainability editor at mindbodygreen, joins the show to share how nature can restore all aspects of your health. You’ll find out how you can reap the benefits of specific nature landscapes, wherever you live or roam.You’ll come away from this episode with: Tips on how to combat stress, anxiety and burnout by being outdoors.Actions you can take to conserve the landscapes you care about.Mindset shifts that will change the way you think about the climate crisis.In her new book, “Return to Nature: The New Science of How Natural Landscapes Restore Us,” she’s researched the ways eight distinct nature landscapes improve your physical, mental and spiritual health. Parks & GardensOceans & CoastsMountains & HighlandsForests & TreesIce & SnowDeserts & DrylandsRivers & StreamsCities & Built EnvironmentsEmma shares research-backed ways to explore nature now and protect it for the future, including SRT (stress-reduction theory). This theory says that humans are hardwired to relax while looking at environments that have extensive views, areas to retreat, and essential resources like shade and water.“Return to Nature” also offers:Mindful exercises you can do in short or long chunks of time that allow you to fully experience nature when you’re in it. Additional resources about the eight natural landscapes Emma writes about.Nearly 30 pages of research references! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Kickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planIsometrics for Cardiovascular Health: https://www.zona.com, use code DAVE2022 to get $150 off the Zona PlusBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS! Go to https://get-base.com/DAVE. Use code DAVE to get 20% off your first purchase.IN THIS EPISODE OF THE HUMAN UPGRADE™...… you’re going to learn about the engineering it takes to build a health data app. You’ll find out how data science, mathematics and predictive analysis look at how biomarkers impact overall wellness. At Base, your own data, along with deep expertise from an advisory board of functional medicine doctors, inform the algorithms. This means you get a distinctly personalized prescription on how to manage your health concerns.Guest Lola Priego, founder and CEO of Base, is an experienced software engineer and former medical student on a mission to help people better understand what is going on in their bodies. She possesses a unique combination of skills to do just that.She studied medicine before transferring to engineering at the Technical University of Madrid and earned a master’s degree in Computer Science and Artificial Intelligence at the Illinois Institute of Technology. While struggling with her own health problems, she identified major pain points in the healthcare system like lack of access to personalized health data. She created Base to solve this issue with a data-driven approach that also provides actionable diet and lifestyle recommendations. Base gets to the root cause of health concerns through analyzing biodata like hormones, nutrition, and vitamin deficiencies to get to the core of why you feel “off.” Base provides testing options that usually are not available at a primary care doctor’s office (they’re often only offered by specialists). Convenience is built into the lab testing process. Base’s blood and saliva tests gets to the root of issues like stress, anxiety, fatigue, and brain fog. Here’s what Base and its accompanying app offer you so you can take control of your own biology and make meaningful life changes:Regular testing tells you what’s going on with your biology.Your own data informs recommendations on how to improve your diet, stress, energy, sleep, and sex drive.You can track your results over time, get help from a team of online experts, and set specific health goals.Because it’s your own health data, there are privacy issues at play you have to know about. Lola explains that security and privacy are built-in design features at Base.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Strengthen Your Back, Align Your Spine: https://bodyaline.com, use code DAVE100 to save $100 Health Upgrades with Custom Lab Testing and Your Data: https://get-base.com/DAVE, use code DAVE to get 20% off your first month of membershipControl Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentIN THIS EPISODE OF THE HUMAN UPGRADE™...… natural vision expert Claudia Muehlenweg shares interesting knowledge and practical solutions about how you can take better care of your eyes and improve your vision. In this longer episode, You’ll discover ways you can improve your vision through natural methods that start with root causes in your body, including nervous system regulation.You’ll explore bodywork, breathwork, rest, light and movement healing methods.You’ll find out the essential Dos and Don’ts for good eyesight.You’ll get practical suggestions for things you can do right now to offset the effects of screen time.You’ll learn how you can keep your vision sharp throughout your life span. After working to improve her own eyesight, Claudia founded Holistic Vision LLC to help others. Her work is based in the Bates Method. She focuses on finding the root cause of blurry vision instead of using symptomatic treatments like glasses, contacts or surgery that actually can make eyesight worse in the long term. She’s been teaching eyesight improvement since 2009. Her methods can improve presbyopia, myopia, astigmatism, hyperopia, strabismus, convergence insufficiency, and eye diseases such as cataracts, macular degeneration and glaucoma. She also helps people restore clarity after corrective surgeries like LASIK have worn off.Her experience as a yoga teacher brings together complementary practices like myofascial release, breathwork and bodywork that greatly influence holistic vision care and natural vision healing methods.SPECIAL OFFERS FOR THE HUMAN UPGRADE LISTENERS!Step 1: FREE 5 Day Training “See Better in Just 5 Days” April 11-15, 2022. Click here to register.Step 2: FREE “See Clearly Without Glasses or Surgery!” live workshops. Choose one date: April 18, 20 or 22, 2022. Click here to register.Step 3: “Naturally Clear Vision” 10-week online holistic vision improvement program. Click here to register-waitlist only.Just want a freebie? “10 Habits for Happy, Healthy Eyes.” Get the guide here.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS! Be Cool, Get Deeper Sleep: Check out the Dock Pro Sleep System at https://www.chilisleep.com/discount/HUMANUPGRADE20. Use code HUMANUPGRADE20 to save 20%.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you’re listening to a new Upgrade Spotlight series based on what you told me you wanted to hear on this podcast. On one Friday each month, these shorter episodes will feature guests who’ll get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you. Introducing ChiliSleep! During this Upgrade Spotlight, you’re going to learn about the physical and mental health benefits of cool sleep and how to hack your sleep with new bed technology.You already know about the physical and psychological effects of not getting good sleep. Whether you’re dangerously sleep-deprived or can’t stop waking up in the middle of the night, struggling to get enough sleep over time can have devastating impacts on your body and mind.Poor sleep increases a person’s risk of developing serious medical conditions, and not getting enough deep sleep increases the chance of high blood pressure; heart attack and stroke; Dementia and Alzheimer’s disease; and Type 2 Diabetes. Tara Youngblood founded ChiliSleep so people could get the coolest sleep ever. Water-based cooling helps your body settle into a just-right temperature that’s just right for you. Your core body temperature should naturally drop every night, but for lots of people for lots of reasons it doesn't. Here are a few of the good things that happen when you regulate your sleep temperature:Cooler temperatures cue your brain to release melatonin and help you fall asleep faster. Sleeping at colder temperatures improves deep sleep and increases muscle recovery.Muscle repair and growth occur during deep sleep and REM sleep stages due to the natural release of growth hormones.Tara creates technologies and apps to help you recover your sleep and your energy. She’s a trained scientist with degrees in Science and Physics who also studied traditional Chinese medicine, Ayurvedic practices, neuroscience, and psychology.She focuses on how your physical body can get better sleep and the important essential link between sleep and mental health.Get Dangerous with Dave's new Remineralized Coffee: https://dangercoffee.comJoin the 8th Annual Biohacking Conference: September 2022! https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Vascular System Protection: https://arterosil.com/DAVE/, save up to 45% a 3-pack to protect your blood vessels from vulnerable plaque.Must-Have Magnesium: https://magbreakthrough.com/DAVE, use code DAVE10 to get a 10% discountBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS! Go to https://www.knowinglabs.com/DAVE. Use code DAVE to get 20% off every home test kit.IN THIS EPISODE OF THE HUMAN UPGRADE™...… you’re going to get a step-by-step guide to taking accurate labs at home. You’ll learn how to use home test kits effectively to get high-quality results.At-home test kits got more popular in the past few years as people wanted to know more about their personal health data. Knowing your data gives you the power to control your own biology.Some of the biggest value drivers of at-home labs include: Convenience, performance specificity, and being proactive rather than reactive about your symptoms.Dolce Conde co-founded Knowing Labs to support a growing community of people who want to be proactive about their health.Knowing Labs offers reliable laboratory testing directly to consumers in the convenience and privacy of their homes. The kinds of test kits available at Knowing Labs include panels for vitamin D, inflammation, sleep & stress, weight & energy, male and female hormones and wellness, and many more.If you want to use home test kits to find out more about your own data and upgrade your health, here are a few essentials to know:It’s important to choose a certified lab.Knowing Labs is a High Complexity CLIA Certified Laboratory in the State of Texas.CLIA means the Clinical Laboratory Improvement Amendments that regulate laboratory testing.All Knowing Labs testing is done in-house so they have total control over the quality and performance of the services.It’s important to understand the type of at-home test kit you have and how to collect accurate samples. This could be saliva, blood or urine, depending on the kit you choose. For blood samples, this could mean a spot, pipette or home phlebotomist visit.Conde talks about some best practices and troubleshooting tips.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Non-Tobacco Nicotine Alternative: https://lucy.co, use code DAVE20 to get 20% off your first order of pouches, gums, or lozengesTasty Keto Bread & Chips: https://www.uprisingfood.com/DAVE, use code DAVE to get $10 off the starter bundleFranchise Opportunity: https://ownanupgradelabs.com, to check out the fitness center of the futureIN THIS EPISODE OF THE HUMAN UPGRADE™...…you’ll take a deep dive into the science of healthy eating so that you can know how to leverage food for high energy and performance.Health and science journalist Max Lugavere studies and writes about ways that food and movement fuel you. And allow you some balance and freedom in your choices.He joins the show to round out a body of work that includes his best-selling “Genius Foods,” “The Genius Life” and now his latest to complete the trio: “GENIUS KITCHEN: Over 100 Easy and Delicious Recipes to Make Your Brain Sharp, Body Strong, and Taste Buds Happy.“It's a kitchen and wellness guide,” Max explains. “I didn't want to just make a book of recipes. That would've been too easy. I wanted to make something that was going to stand the test of time and serve as a resource for people."His work was inspired by his mom’s diagnosis with a rare form of dementia in her 50s. He dedicated himself to her care and also began researching how to prevent cognitive decline through nutrition. “Though I began to cook when my mother could no longer cook herself, I realized that culinary literacy (like health literacy) had become yet another aspect of life that we had outsourced,” Max says in “Genius Kitchen.” I became passionate about creating healthy food that is delicious and easy to make."There’s a multi-billion dollar diet industry that makes nutrition confusing and complex. This conversation gets into the value of simple food, how to find your own food philosophy and why Max rejects diet dogma. So this is the episode for you to:-Learn science-backed tactics to improve digestion, increase nutrient extraction and stop common digestive complaints. -Get practical food lists and cooking methods for easy, nutritious meals that work for your performance goals and everyday life.-Find out how to eat like a “genius” with these topics:The upside & downside of plantsProtein quality & muscle maintenanceOrgan meatsFantastic fats & ominous oilsThe shudder of sugarEssential fatty acidsCalcium & the debate about dairyAnd more!More about Max: Max gets his curious on hosting The Genius Life podcast. He appears regularly on the Dr. Oz Show, the Rachael Ray Show, and The Doctors. He’s been featured on NBC Nightly News, The Today Show, and in The New York Times and People Magazine and contributed to Medscape, Vice, Fast Company, CNN, and the Daily Beast. He’s an international speaker who’s presented at events like South by Southwest, TEDx, the New York Academy of Sciences, and the Biohacker Summit in Stockholm, Sweden.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.Strategic eating fills micronutrient gaps. Use probiotics to turn down your allergies.Your DNA determines your coffee preferences.Got 3 seconds a day? Use it to strength train.Time your meals to control blood sugar and melatonin. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

NAD+ for Brain Health: https://innovativemedicine.com/DAVE and save 20%Support Immune & Digestive Health: https://justthrivehealth.com, use code ASPREY to get 15% offApple Cider Vinegar Benefits: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://farmersjuice.com/pages/upgrade. Use code UPGRADE and save $10 off any box of juice.IN THIS EPISODE OF THE HUMAN UPGRADE™...Did you know?Less than 9% of people meet a daily vegetable intake that’s best for their body.Soil has up to 50% less nutrition than 1945And up to 40% of produce gets wasted on farms. Green juicing—done the right way—can upgrade all of those things. Junaid Kalmadi joins the show to talk about soil degradation, farming practices, and produce waste. He explains that it’s possible to do juicing safely and in ways that don’t break the planet even more.Junaid (with Dave as an advisor) founded Farmers Juice, a keto-friendly and functional green juice line that uses a cold-pressed process. “You separate the pulp from the juice, and you get this end product of this incredibly high nutrient-dense jolt of vitamins, enzymes, phytochemicals that give you this tangible positive effect within your biology, within your mood, within your own like mental state to perform your best,” Junaid says.It takes 1.5 pounds of produce (no kale!)  to make one bottle of organic Farmers Juice. The juices also contain adaptogens, antioxidants, and mushrooms to boost focus, calm, and athletic performance. Along with finding out what’s in the juice, you’ll learn about nutrigenomics and how food information tells your body what to do. You’ll also learn how phytonutrients act as your genetic control system and keep you healthy. Food and nutrients directly, immediately, and specifically interact with our genes, controlling moment-to-moment changes in your physiology and biochemistry.For juicing 101, particularly ingredients and processing, take a listen to: Why Dave Asprey Changed His Mind About Juicing – #802.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Biostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale BusterHydrate with Electrolytes: https://DrinkLMNT.com/DAVE, get a free LMNT Sample Pack with 8 single-serving packets for the cost of shipping ($5 for U.S. customers) Fix Your Feet: https://www.vivobarefoot.com/us/daveasprey, use code ASPREY20 to get 20% off your first order and access to the VHealth Barefoot Movement online coursesIN THIS EPISODE OF THE HUMAN UPGRADE™..You’ll learn about the science-based benefits of intermittent fasting for women, especially during midlife.You’ll get details about intermittent fasting advantages for women like how to gain hormonal stability and metabolic health, and how to improve your energy.You’ll get practical intermittent fasting how-tos, nutritional guidelines, carb cycling recommendations, food lists, and recipes to try during your feeding window.Cynthia Thurlow joins the show to talk about how intermittent fasting can help women change their body, metabolic system and brain function. She has tips for women at all stages: from active menstrual cycles to perimenopause to menopause.Cynthia is a Johns Hopkins-trained nurse practitioner and functional nutritionist founded and serves as CEO of Everyday Wellness Project. She holds a Master of Science degree in Nursing and Functional Nutrition certifications with advanced trainings in Endocrinology and Gastroenterology. Her career in healthcare includes nearly 20 years of emergency medicine and cardiology experience. She brings a broad perspective when working with women to improve the state of their health. “I really start from a foundational level talking to women about fasting,” Cynthia says. “It's really honoring our own unique physiology. It's leaning into that menstrual cycle. It's leaning into the lifestyle piece that so much of us forget to talk about with our patients, our sleep quality, stress management, anti-inflammatory nutrition, our exercise quality, our connection with nature, all of which are critically important.”She also addresses diet dogma that frustratingly persists, even with established and emerging science about the benefits of intermittent fasting.She tackles this outdated dogma (and a lot more!) in her new book, “Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.”“[Intermittent fasting] restores our intrinsic rhythms, burns fat, regenerates our health right down to the cellular level, and stabilizes our hormones,” Cynthia says in her book. “In turn, we are less likely to develop obesity, diabetes, vascular diseases, and autoimmune disorders.”At the end of this conversation, you’ll have the tools to decide if intermittent fasting is the right choice for the state of your own health. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...… Dave talks with Michael Ford about low thyroid function, autoimmunity and aging concerns.At 70, Michael has been biohacking for over three years, takes a consistent supplement regimen, incorporates intermittent fasting, and does frequent microbiome and blood checks.He takes only one medication for low thyroid function and is looking for alternative ways to manage it. He suspects he has an autoimmunity issue and would like to explore that more.In the past few years, Michael has seen the health of colleagues, friends and elderly family members decline considerably. He’s concerned about aging and wants direction on how to live to be fully functional at 140 (or more!). With so much health information available to the general public–much of it contradictory, Michael asks Dave for insight and input.In this “Interventions With Dave” episode, Dave also talks with Michael about:SupplementsTestosteroneCortisol-causing excess weightVisceral fatHealthy fatsRed light benefitsDental healthBreathing & mouth tapingImproving brain blood flowThey look at his health concerns through a new lens and discuss actionable next steps. Don’t miss the “Links & Resources” section below for specific information. Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.Listen to the Interventions With Dave series:Hacking Inflammation #915Hacking Your Gut Microbiome #908Hacking Menopausal Weight Gain #904Hacking Eyesight #895See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Nature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% offCARBON60 for Brain & Body: https://wizardsciences.com, use code DAVE for an exclusive discount on C60 productsTrigger Autophagy: https://spermidinelife.us/dave, use code DAVE25 for 25% off your first month’s orderSpecial offer for The Human Upgrade listeners: Go to https://www.viome.com/daveasprey, use code DAVE to get $20 off a Health Intelligence™ Test.IN THIS EPISODE OF THE HUMAN UPGRADE™...Dave’s good friend, entrepreneur and philanthropist Naveen Jain, joins the show to talk about the future of human biology and wellness. What’s new right now, what’s emerging, and what’s on the horizon. He’s been a guest several times before (see the Links & Resources section below!) and there’s always something new to learn when he and Dave get together. This time, they explore testing the human biome.Naveen’s a guy with enormous vision who builds companies and partners with others to tackle and solve the gnarliest problems affecting the health of our people and planet. He always encourages curiosity and big thinking: ““Curiosity is what drives the humanity forward. The day you stop being curious is the day you die.”In this discussion, you’re going to learn ways innovation can change human biology from a micro and macro level—from your cellular health to broader planetary issues. You’ll also learn how you can test to find out what’s happening within your gut, cells and immune system. With that knowledge and personalized recommendations, you’ll have the power to change your health for the better.Naveen founded, Viome, the worlds’ largest database of microbial gene expression. Its AI-driven personalized therapeutics platform and applications identifies predictive markers of chronic diseases. Viome does this by using a functional analysis of microbial, mitochondrial and human gene expression. “We actually see everything,” Naveen explains. “As long as an organism is alive, we see it. So whether it is a bacteria, virus, fungus, mold, it doesn't matter. We see everything.”In particular, Viome’s Health Intelligence™ Test looks at:gut microbiomemitochondrial functionimmune cell functioncellular healthstress responsebiological ageThe more data can inform what’s happening inside of you, the more resources you’ll have to improve your health.More about Naveen Jain:Naveen wrote the award-winning book, Moonshots: Creating a World of Abundance and created Mindvalley, Masterclass programs. He’s behind XPrize, a global future positive movement and is on the board of Singularity University. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Business Growth With SEO: https://www.stephanspencer.com, get a FREE consultationProbiotic Eases Stress: https://www.omnibioticlife.com/DAVE/, use code DAVE20 to get 20% offControl Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentIN THIS EPISODE OF THE HUMAN UPGRADE™... … Ellen Vora, M.D., takes a functional medicine approach to mental health that considers the whole person and addresses imbalance at the root. She’s a Yale and Columbia University educated holistic psychiatrist board-certified in psychiatry and integrative holistic medicine. She’s also an acupuncturist and yoga teacher.In her new book, “The Anatomy of Anxiety: Understanding and Overcoming the Body's Fear Response,” she takes on anxiety, which hits more than 40 million people in any given year. The pandemic drove that number up even more. Even if math isn’t your strong suit, you can understand these numbers:An estimated one out of every nine people, or 800 million people, suffer from a mental health disorder, the most common of which is anxiety. Up to 33.7 percent of Americans are affected by an anxiety disorder in their lifetime. Conventional medicine tends to view anxiety as a “neck up” problem of brain chemistry and psychology. Dr. Vora disagrees. She suggests that various physiologic inputs influence anxiety symptoms. “What we've been indoctrinated with is this idea that our mental health is genetically determined chemical imbalance,” Dr. Vora says. “There's some validity to that, although I think, for the most part, any chemical imbalance is often a downstream effect of a state of imbalance happening elsewhere in the physical body.”In this episode, you’ll learn:the difference between avoidable, purposeful, false and true anxiety;simple strategies for tuning into “true” anxiety and using its benefits;how your body may be physiologically out of balance (immunity, gut health, inflammation);how “hanxiety” means that blood sugar is affecting your anxiety; actionable lifestyle factors to bring yourself back into balance; how to manage medication withdrawl; and how to reframe your understanding of, and relationship with, anxiety.Dr. Vora also confronts what she calls techxiety. This can include a boundaryless workplace, how the posture of screen use signals your body for anxiety, and, of course, social media. Research shows social media is associated with higher rates of anxiety and depression. Just 20 minutes of Facebook can impact mood.So much of how you live your life as an adult profoundly impacts how your mental health manifests, and that's the part you can control.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

IN THIS EPISODE OF THE HUMAN UPGRADE™...… Dave talks with Cindy Fraley-Hunter about system-level inflammation and her fear of having an early heart attack like her father because they have such similar genes.Cindy thought she was healthy until after the birth of her daughter at 42. She was constantly tired. Her physician told her that was just to be expected because she was a geriatric pregnancy. That unhelpful advice ignored her body functioning and lacked actionable solutions.She then survived a case of MRSA and received Hashimoto’s and rheumatoid arthritis diagnosis. She continued to have high cholesterol and a high CAD calcium heart score. She’s scared her life will be cut short.Feeling like conventional medicine is failing her, Cindy has turned to supplements instead of prescription drugs. She says she’s “embracing biohacking to save my life.”In this “Interventions With Dave” episode, Dave walks Cindy through her most recent labs and other test results. They look at her health concerns through a new lens and discuss actionable next steps. Don’t miss the “Links & Resources” section of episode web page #915 for specific information.Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.Listen to the Interventions With Dave series:Hacking Your Gut Microbiome #908Hacking Menopausal Weight Gain #904Hacking Eyesight #895Coffee & Bohacking with Dave Asprey(coffee + minerals) - toxins = power: Discover the energy and high performance that come from Danger Coffee, designed with your biology in mind. https://dangercoffee.com8th Annual Biohacking Conference: Come join like-minded people September 15, 16 & 17 in Beverly Hills, Calif., for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life.https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Natural First-Aid Healing: https://3rdrockessentials.com, use code DAVE to save 20%Non-Tobacco Nicotine Alternative: https://lucy.co, use code DAVE20 to get 20% off your first order of pouches, gums, or lozengesBiostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale BusterIN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll get a look at synthetic biology (SYNBIO) through the lens of quantitative futurist Amy Webb in Part 2 of a special two-part episode. The Part 1 episode #913 explores the scientific perspective with microbiologist and geneticist Andrew Hessel.Amy and Andrew recently authored, “The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology.” SYNBIO is the promising and controversial technology platform that combines biology and artificial intelligence. Amy investigates what SYNBIO means for people, commerce and the planet. “This is a book about science,” Amy describes, “but I did not want to write a science book. This is also a business book. It's an understanding-your-own-body book.”She’s a futurist who works with data and does predictive modeling. Her academic background includes game theory and economicsAmy founded the Future Today Institute to help companies understand the forces that will shape their futures. She’s a professor of strategic foresight at the NYU Stern School of Business and a Visiting Fellow at Oxford University’s Säid School of Business. She writes extensively about biotechnology, artificial intelligence, technology policy, and business strategy.“This emerging field of science—synthetic biology—promises to reveal how life is created and how it can be recreated, for many varied purposes, as explained in “The Genesis Machine:”to help us heal without prescription medications, to grow meat without harvesting animals, and to engineer our families when nature fails us.With SYNBO developments come a slew of considerations about how to manage it responsibly.“For the most part, in the US, the regulation is on the end product,” Amy says. “Nobody wants to regulate the process, because we don't want to hamper innovation. However, it does start to raise some gnarly questions when we're talking about alternative uses or different uses for some of these technologies, or cross-border use.”“There's some alignment globally on what's called germline editing, which is when you edit the genome to make it heritable. So whatever that is passes on. At the moment, just about 190 countries have aligned [to agree] that they don't want that to happen. But outside of that, there's a lot of confusion.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Nature’s Nootropic: https://trukava.com,use code DAVE15 to get 15% offApple Cider Vinegar Benefits: https://paleovalley.com/DAVE, use code DAVE to get 15% off your first orderFranchise Opportunity:https://ownanupgradelabs.com, to check out the fitness center of the futureIN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll learn about the implications of synthetic biology in Part 1 of a special two-part episode.Andrew Hessel and Amy Webb recently authored, “The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology.” This Part 1 episode gets into the scientific perspective with Andrew. Part 2 on episode #914 explores the futurist perspective with Amy.Ask yourself, if you could edit your genes—to fix infertility, diabetes or even depression—would you do it? That’s the premise, and the promise, of synthetic biology. And a reality you’ll have to wrestle with. To make these decisions intelligently requires a deeper—and urgent—understanding of what’s happening in science.Right now, scientists are rewriting the rules of our reality. They can use computers to gain access to the cells of any living organism and write new, potentially better, biological code. Andrew—a microbiologist and geneticist—works on the leading edge of genomics and bioinformatics. He’s been immersed in the world of synthetic biology for years and joins the show to explain new advancements.As a scientist, communicator, and investor, he explores the future of biology and biotechnology. He co-founded the Center of Excellence for Engineering Biology and the Genome Project-write. The Genome Project-write is an international scientific effort that designs and builds large genomes, including the human genome. As we embrace that life no longer will be a game of chance, it will be the result of design, selection and choice, morechoices have to be made. Decisions like who gets to program life, create new life forms, and even bring former life back from extinction?“The Genesis Machine" is a book about science, but it's not written for scientists, Andrew says. “It's about some amazing people and stories and we've got some fun scenarios that help you think about where some of this stuff is going. But really, this is a technology that we're all building day by day.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Control Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentKickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planNAD+ for Brain Health: https://innovativemedicine.com/DAVE and save 20%SPECIAL OFFERS FOR THE HUMAN UPGRADE LISTENERS:Pre-order your copy of “Unlocking the Keto Code” before March 7, 2022, and receive your choice of “The Energy Paradox,” or “The Plant Paradox,” or an early release chapter of “Unlocking the Keto Code,” and an exclusive sneak peek digital recipe guide! Go to https://drgundry.com for details. Get 30% off products at https://gundrymd.com. Use code DAVE30 at checkout.IN THIS EPISODE OF THE HUMAN UPGRADE™...… Steven Gundry, M.D., introduces you to the biological mechanism that makes keto diets so successful: a cellular process known as “mitochondrial uncoupling.” He’s spent the last two decades studying the microbiome and uses diet and nutrition as a key form of treatment for people who want to improve their body health and performance. You may already know Dr. Gundry from his bestselling books like: “The Plant Paradox,” (lectins!) “The Longevity Paradox” and “The Energy Paradox.” This discussion gets right into new science that’s overhauling what you think you know about a keto diet. In his newest book, “Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation,” Dr. Gundry debunks common myths about keto and explains:How ketosis actually works,What’s going on with ketones, and What your mitochondria has to do with all of this.You don’t have to restrict all carbs to reap the benefits of ketosis; you simply have to “unlock” mitochondrial uncoupling, Dr. Gundry explains.He shares eight “keys” that unlock the keto code. You’ll get real food examples of how to ignite this process without the monotonous, limiting, high-fat diet.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Mattress Temperature Tech: https://www.eightsleep.com/dave, use code DAVE to save $250 on the Pod ProMust-Have Magnesium: https://magbreakthrough.com/DAVE, use code DAVE10 to get a 10 percent discountOrganically & Biodynamically Grown: https://www.dryfarmwines.com/dave, get an extra bottle in your first box for just a penny. (Free shipping except Hawaii & Alaska.)IN THIS EPISODE OF THE HUMAN UPGRADE™...Entrepreneur, investor and artist Payal Kadakia brings a fresh perspective to your understanding of goals. She knows a lot about setting big goals and reaching them.She founded ClassPass and over a decade grew it to become the leading fitness and wellness membership service valued at over $1 billion. Mindbody acquired ClassPass in October 2021. At that time, members had logged more than 100 million hours of workouts across 30,000 partner studios in over 30 countries. We’re going to talk today about how you can upgrade your own goal setting with “LIFEPASS: Drop Your Limits, Rise to Your Potential.” Using her company Class Pass as an example, Payal highlights the importance of knowing your strengths, your unique talents,  who you are, and investing in the right people and mentors to show you the way. Payal gives insight on how to set boundaries in service to your priorities, and how every minute of the day belongs to YOU, not anyone else. This means you don’t have to hold onto any guilt about doing what's right for you.You’re more likely to reach your goals when you get to let go of the pressure to achieve a traditional kind of success and instead fuel your life with purpose. And when you focus on a life of creativity, you get to live the life you most want to live.The 4-step LifePass Method combines intuition, pie-in-the-sky dreams, micro focus, and macro goals.Reflect: Where have you been?Dream: Where do you want to go?Focus: What are your priorities?Set Goals: What’s the plan?Payal, an Operations Research and Economics graduate from MIT, been featured in most major news outlets; listed as Fast Company’s 100 Most Creative People; and named to Fortune's 40 under 40 list. She formerly worked as a consultant at global management consulting firm Bain & Company and was part of Warner Music Group’s Digital Strategy and Business Development Group. She’s also got an extraordinary artistic side. She founded The Sa Dance Company in 2008 and serves as Artistic Director.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.Breathing coordinates neuronal activity—even without smellMindful breathing in virtual reality can control real pain Circadian cycle affects immune cells and Alzheimer’s plaquesBrain refresh lags when processing visual stimuliMedical repression in the days of Ivan the TerribleSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.