The Energy Balance Podcast

In this episode we discuss: Whether “calories in, calories out” is physiologically accurate The many misconceptions related to “calories in, calories out” Why a calorie deficit is NOT required for fat loss Why “calories in, calories out” does not mean that eating less and exercising more is good advice for fat loss What most people miss when it comes to “calories in, calories out” Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-123-debunking-the-cico-myth-calorie-deficits-are-not-required-for-fat-loss/ Timestamps: 0:00 – intro 1:07 – questions about the calories-in, calories-out (CICO) model of weight loss that I’ll be answering 7:18 – what is (and isn’t) a calorie? 11:49 – misapplications of CICO and why CICO is not physiologically accurate in the ways most people use it 19:46 – why the idea that “a calorie is a calorie” is misleading 29:11 – how energy in food is measured and the inaccuracy of food labels 36:16 – the impact of behavioral compensation and metabolic adaptation on energy expenditure 42:07 – how cutting calories lowers metabolism, reduces thyroid function, and increases stress hormones, appetite, and weight regain 48:26 – Herman Pontzer’s Constrained Model of Energy Expenditure and the adverse effects of energy deficits 52:21 – whether CICO can accurately represent physiology 1:00:04 – a simplified version of CICO 1:05:41 –why calories do not equal usable energy or weight 1:13:27 – examples demonstrating the issues with common CICO misconceptions 1:21:09 – summarizing the central issues with CICO and how you can lose body fat without a caloric deficit 1:28:13 – whether there’s value to CICO

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Danny's Telegram: https://t.me/dannyroddy Timestamps: 0:00 – intro 0:33 – why we started this podcast 6:25 – our take on Bryan Johnson’s Longevity Blueprint and problems with biohacking 12:13 – whether we should adopt any of the strategies from Bryan Johnson’s Blueprint to achieve optimal health 14:50 – the cost of continually being in a caloric deficit and why this does not increase longevity 21:06 – issues with eating hard-to-digest foods and whether supplements can make up for missing nutrients in the diet 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 28:00 – potential pros and cons of Bryan Johnson’s Blueprint and how to measure health 32:39 – Bryan Johnson’s supplement protocol 41:09 – how low-carb diets negatively affect NAD+ to NADH ratios and estrogen status 46:20 – whether body fat percentage and cholesterol levels can be too low 52:20 – what is stress? 1:03:20 – issues with hormesis and the idea that stress is beneficial 1:07:34 – whether avoiding stress is possible and how to develop resilience to stress 1:13:17 – addressing Marty Kendall’s response to our take on glucagon and insulin 1:24:17 – glucagon’s short-term and long-term effects on metabolic function 1:26:46 – glucagon’s role in insulin resistance and type 2 diabetes 1:37:16 – metabolic dysfunction as a driver of insulin resistance 1:41:06 – whether we need to be concerned about wasting energy on hormone production 1:44:50 – whether we should always try to avoid gluconeogenesis 1:51:45 – how to use carbohydrates to stabilize your blood sugar 1:56:11 – habit stacking, simplifying supplementation, and adopting a long-term mindset when it comes to health

In this episode we discuss: Whether Berberine and Urolithin A are good options for weight loss How Berberine lowers your blood sugar and whether this is really a good thing The effects of Berberine and Urolithin A on your gut Whether you always need to avoid blood sugar spikes Whether you always need to have protein with your carbohydrates Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-122-weight-loss-with-berberine-and-urolithin-a-blood-sugar-spikes-and-pairing-protein-with-carbs-qa/ Timestamps: 0:00 – intro 1:10 – what are berberine and urolithin A? 2:26 – the benefits of berberine on gut health 9:06 – berberine as a mitochondrial poison and the mechanisms of berberine’s toxicity and blood-sugar-lowering effects 13:13 – of the effects urolithin A on mitochondria and the gut 18:15 – whether urolithin A is beneficial for weight loss and increases brown adipose tissue activity 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 26:31 – powerful weight loss strategies that are simple and effective, without supplementation 31:02 – whether we always need to avoid blood sugar spikes and dips 35:30 – when having protein alongside carbs is necessary and why increasing carbohydrate intake improves insulin sensitivity, even in people with type 2 diabetes 40:49 – how fat, fiber, and protein help slow the absorption of carbohydrates and improve blood sugar management 46:20 – issues with grain-based carbs and the importance of finding carb sources that work for you

In this episode we discuss: How to fix adrenal fatigue and adrenal insufficiency and whether these are really adrenal problems Whether it makes sense to use desiccated adrenal products or hydrocortisone for adrenal fatigue How the GAPS diet can resolve autoimmune issues and whether you should consider trying it How to improve fat digestion and bile flow How to improve digestion without a gallbladder Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-121-how-to-address-adrenal-fatigue-gaps-diet-concerns-and-gallbladder-health/ Timestamps: 0:00 – intro 1:13 – what is adrenal insufficiency and what causes it? 7:02 – what is adrenal fatigue and how can we reverse it? 11:54 – the drivers of adrenal fatigue and issues with typical treatments 18:51 – the importance of establishing solid diet and lifestyle foundations before adding supplements for adrenal support 24:42 – whether our bodies lose the ability to produce hormones as we age 27:20 – concerns with the use of natural supplements like desiccated adrenal glandulars, licorice, and hormone replacement therapy (HRT) 36:07 – whether the GAPS diet is ideal for healing autoimmune conditions 40:01 – problems with the GAPS diet and other elimination diets 47:37 – the importance of individualizing your gut protocol and the problems with a cookie-cutter approach 52:09 – the connection between gut health, stress hormones, mental health, and autoimmunity 55:40 – how to improve digestion without a gallbladder 59:13 – common issues seen in those without a gallbladder 1:02:08 – long-term consequences of gallbladder removal and how to heal gallbladder issues 1:05:30 – when to use ox bile, TUDCA, taurine, glycine, or vitamin C 1:09:16 – how much fat to include in your diet to stimulate bile flow, and what types of fats are optimal 1:12:55 – strategies for preventing and resolving bile dumping and reflux 1:15:44 – additional consequences of gallbladder removal 1:17:36 – gallbladder issues in relation to hypothyroidism and estrogen dominance

In this episode we discuss: The research behind vitamin A toxicity and whether vitamin A is really a poison Whether you need to be concerned about the use of Accutane Whether retinoic acid is toxic because it’s used as a chemotherapeutic agent Whether Grant Genereux’s claims about vitamin A toxicity are valid Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-120-vitamin-a-toxicity-retinoic-acid-toxicity-accutane-and-whether-hypervitaminosis-a-exists Timestamps: 0:00 – intro 1:15 – why we're examining Grant Genereux's take on vitamin A toxicity and the evidence behind his claims 4:50 – conceptualizing the amount of vitamin A needed for toxicity 7:07 – is hypervitaminosis A (vitamin A toxicity) real? 9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis 12:36 – is there a conspiracy to poison the masses with vitamin A? 18:36 – how likely is it that you have vitamin A toxicity? 22:30 – problems with the first in vivo study that Grant uses to support vitamin A toxicity 35:14 – vitamin A toxicity in the studies Grant cited require massive doses of vitamin A that would be impossible to obtain from diet 42:44 – Grant’s cited research actually supports the safety of vitamin A 50:52 – more of Grant’s cited research supporting vitamin A safety 58:25 – further research supporting that extremely high doses are required to cause vitamin A toxicity 1:07:57 – whether vitamin A toxicity is driving autoimmunity 1:09:54 – whether retinoic acid is toxic based on concerns regarding the use of Accutane 1:15:40 – how conflating Accutane with retinoic acid is misleading 1:22:12 – whether retinoic acid is toxic because Accutane is used as a chemotherapeutic agent 1:29:37 – evaluating Grant’s claim that retinol automatically becomes “toxic” retinoic acid 1:35:05 – our concluding thoughts on Grant’s arguments regarding vitamin A toxicity

In this episode we discuss: Whether vitamin A toxicity exists and is something you need to be worried about Whether Grant Genereux’s claims about vitamin A deficiency are valid Whether vitamin A is actually a poison rather than a vitamin What we think about the current state of the Ray Peat forum The research on vitamin A deficiencies and whether vitamin A deficiencies exist Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-119-vitamin-a-toxicity-examining-the-evidence-for-vitamin-a-deficiency Timestamps: 0:00 – intro 1:09 – why we’re discussing vitamin A toxicity and Grant Genereux’s perspective 4:53 – closedmindedness within the “low vitamin A” sphere and how it compares to Ray Peat’s work 7:33 – how a low vitamin A diet can have benefits 9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis 12:33 – the importance of evaluating information objectively while avoiding censorship, tribalism, fearmongering, and religiosity 21:17 – concerns with the current state of the Ray Peat Forum and how to recognize unsubstantiated claims 26:45 – Grant's initial critiques of the original studies on vitamin A deficiency are extremely weak and unsubstantiated 41:48 – introducing Wolbach’s 1925 study on vitamin A deficiency 45:47 – refuting Grant's argument that the retinoic acid in the vitamin-free casein would have caused toxicity 52:35 – refuting Grant's argument regarding confounding variables in lard and butter 1:02:53 – research on vitamin A deficiency and whether vitamin A deficiencies exist 1:20:32 – the necessity of vitamin A for pregnancy, fetal growth, and development

In this episode we discuss: Why serotonin is NOT the “happy hormone” and you may not want to increase it How serotonin and depression relate to stress and energy balance Whether SSRIs are effective for depression How SSRIs actually work, their impact on metabolism, and whether they’re the best treatment option for depression The real drivers of depression and anxiety Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-118-the-truth-about-serotonin-and-ssris-why-serotonin-is-not-the-happy-hormone Timestamps: 0:00 – intro 0:58 – the research showing that serotonin is not the “happy hormone” 4:56 – serotonin’s role in driving the stress state that leads to depression 8:26 – the overlap between anxiety and depression and why they are both characterized by elevated serotonin levels 10:27 – the origins of the idea that serotonin is the “happy hormone” and how serotonin became a marketing tool for pharmaceutical companies 14:49 – serotonin is increased during fasting and starvation and why increasing serotonin should not be our goal 20:16 – serotonin is increased during stress, shock, and infection and leads to learned helplessness 29:04 –SSRIs use in neonates causes depression in adulthood 31:35 – the serotonergic system as an adaptive stress response to a lack of energy 39:09 – serotonin’s role in energy redistribution under stress 43:15 – how SSRIs inhibit mitochondrial respiration, glucose metabolism, and energy production in the brain and liver 47:13 – how SSRIs can reduce symptoms and how the brain responds to SSRIs 52:42 – the true drivers of depression and anxiety 1:01:30 – how serotonin relates to stress hormones, including cortisol, and energy balance

In this episode we discuss: Concerns surrounding fructose malabsorption and whether fructose is really a FODMAP Whether you need to be concerned about excess fructose in foods Whether you should avoid sugar and supplement with fish oil for brain inflammation Diet and supplement strategies for brain injuries The impacts of drinking alcohol from the Bioenergetic view Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-117-fructose-malabsorption-protecting-against-alcohol-and-brain-injuries-and-inflammation-q-and-a Timestamps: 0:00 – intro 1:15 – how fructose gets absorbed in the small intestine 4:24 – the optimal fructose to glucose ratio and how to tell if you have fructose malabsorption 8:41 – the details of how glucose helps with fructose absorption 12:04 – which foods have a high fructose to glucose ratio 16:24 – issues with FODMAP categorization and whether fructose is really a FODMAP 21:23 – listening to your body and understanding individual context vs following rigid “food rules” 27:39 – anti-inflammatory diets and whether we should avoid sugar and supplement with fish oil to reduce brain inflammation 32:06 – dietary and supplement strategies to promote an anti-inflammatory state in the brain 39:15 – the effectiveness of red-light therapy, methylene blue, progesterone, exogenous ketones, and polyphenols in treating brain injuries 44:31 – why we don’t want to prioritize omega 3s in the diet and whether eating fish is any better than fish oil supplementation 47:21 – reducing inflammation with the use of aspirin 47:53 – the main concerns with drinking alcohol: intestinal permeability, endotoxin production, and liver health 52:32 – stress-relieving supplement alternatives to alcohol and the effects of alcohol on vitamins and minerals 54:37 – strategies to mitigate the effects of alcohol in the short-term 58:14 – whether it makes sense to drink alcohol, alcohol use as a coping mechanism, and the impact of culture 1:00:07 – more strategies for mitigating the effects of alcohol in the short and long term

In this episode we discuss: The validity of the counterarguments against the Lipid Energy Model Whether the Lipid Energy Model means that high LDL does not increase cardiovascular disease risk How thyroid and metabolism relate to high LDL on a low-carb diet What the Lean Mass Hyper-Responder phenotype means in terms of metabolic health Whether low-carb diets are ideal for cardiovascular disease health and health in general Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-116-the-truth-about-ldl-and-heart-disease-lmhr-and-the-lipid-energy-model/ Timestamps: 0:00 – intro 1:17 – the primary counterarguments against the Lipid Energy Model 4:15 – BMI, not saturated fat, correlates with the LMHR phenotype 8:15 – eating carbs dramatically lowers cholesterol in LMHR 11:14 – whether Oreos are more effective at lowering cholesterol than statins 17:30 – high cholesterol levels in the LMHR phenotype are not due to excess saturated fat intake or cholesterol production 19:25 – prominent cardiologists and researchers dismissing the lipid energy model due to dogmatism interferes with progress in science and medicine 24:40 – Dr. Shawn Baker’s carbohydrate experiment and contextual considerations when reintroducing carbs into the diet 28:46 – further support for the lipid energy model and the relationship with thyroid function 33:32 – the difference between saturated, monounsaturated, and polyunsaturated fats in relation to lipid profiles 34:40 – whether LDL cholesterol and ApoB cause heart disease and plaque formation 42:18 – how the Lipid Energy Model helps uncover the underlying cause of heart disease 45:15 – LDL levels as a marker of metabolic health rather than a cause of cardiovascular disease and why we may not always want to lower LDL 55:02 – evidence suggesting that LDL does not drive cardiovascular disease 1:05:43 – the difference between high LDL due to metabolic dysfunction and high LDL due to a low-carb diet 1:09:58 – lipid values don’t tell us the whole picture: the Kitavans 1:16:54 – why decreases in insulin, glucose, and HbA1C as well as increased lipolysis and fat oxidation on a low-carb diet is not necessarily a sign of improvement 1:22:57 – increased lipolysis on low-carb diets does not lead to body-fat loss 1:24:25 – whether the Lipid Energy Model proves that low-carb diets are optimal for health

In this episode we discuss: Whether you should be concerned about high LDL or high cholesterol on a low-carb diet The validity of the Lean Mass Hyper-Responder (LMHR) Phenotype and Lipid Energy Model proposed by Dave Feldman The metabolic state that drives the Lipid Energy Model How the "Lean Mass Hyper-Responder" and Lipid Energy Model support the Bioenergetic view of cardiovascular disease Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-115-lmhr-and-the-lipid-energy-model-implications-for-metabolism-and-hormones Timestamps: 0:00 – intro 1:14 – what is the Lean Mass Hyper-Responder (LMHR) phenotype 3:33 – how the Lipid Energy Model challenges the mainstream dogmatic view linking high cholesterol levels to heart disease 6:33 – the protective effects of cholesterol and why it does not cause heart disease, despite being necessary for atherosclerosis 9:49 – the distinction between Lean Mass Hyper-Responders and those with high cholesterol levels in the context of metabolic dysfunction 15:10 – what is the Lipid Energy Model 22:10 – how the body adapts to a lack of carbohydrates, leading to elevated cholesterol levels 27:22 – the hormonal and metabolic state underlying the Lean Mass Hyper-Responder phenotype 32:21 – how adding carbohydrates lowers cholesterol levels in those who don't have metabolic dysfunction at a cellular level 37:11 – whether Lean Mass Hyper-Responders are at increased risk of cardiovascular disease 42:00 – why the Lean Mass Hyper-Responder phenotype isn't ideal: stress and low thyroid function 51:10 – the parallels between the lipid energy model and physiological insulin resistance

In this episode we discuss: How increasing carbohydrate intake actually improves insulin sensitivity, even in people with type 2 diabetes The research showing that fatty liver disease and cardiovascular disease are both characterized by excess fatty acid oxidation The research showing that fatty liver disease and cardiovascular disease are both characterized by excess fatty acid oxidation Why strategies such as intermittent fasting, cold plunges, and OMAD (one meal a day) are not effective for improving insulin sensitivity Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-114-fat-burning-drives-insulin-resistance-and-eating-carbohydrates-improves-insulin-sensitivity/ Timestamps: 0:00 – intro 1:17 – stress hormones (glucagon, epinephrine, and cortisol) are major contributors to insulin resistance and diabetes 4:05 – elevated glucagon levels, not carbohydrates, are the driving force behind high fasting blood glucose levels 6:43 – glucagon is a driver of insulin resistance, while insulin is just a symptom 12:46 – the research showing that blocking stress hormones directly improves insulin sensitivity 15:14 – “hormetic” stressors like intermittent fasting, cause insulin resistance 19:30 – fat burning drives insulin resistance and keeps us in a catabolic state, driving weight gain and muscle wasting 22:15 – cortisol drives insulin resistance and why serum cortisol levels don’t provide the full picture 25:00 – low-carb diets reduce insulin sensitivity while carbohydrate intake improves it 29:40 – decreasing fatty acid oxidation by increasing carb intake improves our ability to tolerate carbohydrates 33:46 – burning fat contributes to increased disease processes and does not lead to losing more body fat 38:04 – fatty acid oxidation damages our mitochondria and increases fat storage 46:22 – type 2 diabetes directly contributes to heart disease by upregulating fatty acid oxidation 52:05 – how to decrease fatty acid oxidation and improve glucose metabolism

In this episode we discuss: Insulin resistance and type 2 diabetes are diseases of excess fat burning and impaired glucose metabolism How increasing carbohydrate intake improves insulin sensitivity, even in people with type 2 diabetes Evidence supporting the bioenergetic view of insulin resistance and type 2 diabetes Why carbs are not actually the cause of insulin resistance and diabetes Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-113-carbohydrates-dont-cause-insulin-resistance-or-diabetes-evidence-for-the-bioenergetic-view Timestamps: 0:00 – intro 1:28 – what the mainstream view of insulin resistance gets wrong when it comes to what causes insulin resistance and diabetes 3:24 – glycolysis and fat oxidation are favored, and glucose oxidation is inhibited in insulin resistance and diabetes 8:39 – what happens to glucose in diabetic cells 10:32 – why insulin resistance is a symptom rather than the driver of diabetes 12:55 – research showing that insulin resistance is driven by poor glucose metabolism 20:50 – impaired glucose uptake is not caused by excess insulin; fat-burning and impaired glucose metabolism are the culprits 27:10 – the problems with relying on fat oxidation over carbohydrate oxidation 30:43 – how increasing blood glucose levels or increasing insulin can restore normal glucose uptake in diabetes 35:28 – how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones 37:16 - why fatty acid oxidation is NOT the underlying cause of insulin resistance 40:06 – factors that support or block mitochondrial respiration 41:20 – how excess fatty acid oxidation contributes to the pathology of insulin resistance and can impair glucose metabolism over time 42:49 - how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones (cont.) 47:08 – why we don’t want to blame insulin for insulin resistance and what really causes high fasting blood glucose 49:22 – how low-carb diets increase stress hormones and decrease insulin sensitivity

In this episode we discuss: Why you might want to think twice about using resistant starch for blood sugar regulation and gut health Ways to increase or reduce the amount of resistant starch in the foods you eat How to tell if resistant starch is negatively impacting your gut health, and why non-resistant starch may also pose a problem The optimal calcium to phosphorus ratio according to the research The calcium paradox and why calcium intake doesn’t increase excitation or calcification The hidden dangers of excess phosphorus intake Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-112-the-problems-with-resistant-starch-and-balancing-the-calcium-to-phosphorus-ratio-qa Timestamps: 0:00 – intro 1:00 – mainstream health claims about resistant starch and why we disagree 6:15 – whether there are any benefits to including resistant starch in your diet 11:07 – how to tell if resistant starch is negatively impacting your gut health and how to avoid it 16:05 – which starches are easiest to digest and the factors that affect our ability to digest starches optimally 21:38 – why we should pay attention to our calcium to phosphorus ratio and the risks of high parathyroid hormone levels 26:19 – the optimal calcium to phosphorus ratio and the calcium paradox in terms of regulating blood pressure 31:21 – which phosphorus-containing foods we should avoid to optimize bone density 34:36 – the calcium paradox and why consuming calcium doesn’t increase intracellular calcium

In this episode we discuss: How spore-based probiotics differ from typical probiotics and whether we should be using either of them to improve our gut health Whether low-carb or ketogenic diets are an ideal solution for epilepsy The role of gut health and metabolism in epileptic seizures Concerns with using low- or no-calorie sweeteners Whether stevia is actually any better than artificial sweeteners Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-111-stevia-vs-sugar-ketogenic-diets-for-epilepsy-and-spore-based-vs-standard-probiotics-qa Timestamps: 0:00 – intro 1:17 – whether spore-based probiotics can cause bacterial overgrowths like SIBO 4:53 – the drawbacks of standard probiotic use and the limitations of stool testing 9:55 – how spore-based probiotics protect against pathogenic bacteria and endotoxin and which spore-based product Jay recommends 15:39 – long-term benefits of spore-based probiotics and how long you need to use them for these benefits 21:05 – whether low-carb or ketogenic diets are necessary to improve epilepsy 29:25 – using ketones for fuel and why the production of ketones isn't the problem on a ketogenic diet 30:48 – the main drivers of epileptic seizures and how ketones help to prevent or reverse them 34:17 – the role of the gut microbiome in brain health and epilepsy 42:18 – concerns with low- or no-calorie sweeteners like stevia 48:03 – whether we should be concerned about the lack of nutrients in table sugar, honey, and maple syrup 54:55 – stevia as a potential endocrine disruptor that may have negative effects on the thyroid, liver, and kidneys

In this episode we discuss: Why insulin resistance and diabetes are not caused by excess carbohydrate consumption and are not actually an insulin signaling problem The problems with the idea of metabolic flexibility, earning your carbs, and the carb-insulin model of obesity Why carbs are beneficial even for people who have insulin resistance or diabetes The role of fat burning and stress in driving insulin resistance Specific diet, movement, and supplement recommendations to reverse insulin resistance and diabetes Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-110-the-true-cause-of-insulin-resistance-and-diabetes-from-the-bioenergetic-view/ Timestamps: 0:00 – intro 1:14 – metabolic flexibility, earning your carbs, the carb-insulin model of obesity, and dispelling other common insulin resistance myths 7:48 – low-carb, keto, and carnivore diets may improve symptoms but are not the solution for insulin resistance 13:13 – what the mainstream views of insulin resistance gets wrong when it comes to what causes insulin resistance 15:50 – why you might not want to use a continuous glucose monitor and the unnecessary fear of blood glucose spikes 17:48 – whether insulin is harmful and whether we want to keep insulin levels as low as possible 22:15 – whether we can restore optimal insulin sensitivity without low-carb diets 25:16 –the bioenergetic view of insulin resistance 27:12 – insulin resistance as an adaptive evolutionary process that is crucial for survival 31:22 – the difference between physiological and pathological insulin resistance 34:40 – how inhibited glucose oxidation causes insulin resistance 40:46 – how fatty acid oxidation causes increased production of ROS, slows cellular respiration, and blocks glucose oxidation (The Randle Cycle) 51:06 – the harms of ROS production from fatty acid oxidation and other forms of stress 53:04 – insulin resistance as an energy deficient state 54:19 – insulin resistance is not an insulin signaling problem, it’s an energy production problem 58:30 – the role of stress hormones (like cortisol) in insulin resistance 1:02:09 – how insulin and carbohydrates decrease stress 1:05:59 – how to fix insulin resistance and restore insulin sensitivity by fixing our capacity to produce energy 1:10:38 – specific diet, movement, and supplementation recommendations for insulin resistance and diabetes 1:17:55 – why you don’t need to tailor your carb intake to your carb tolerance

In this episode we discuss: Our thoughts on Chris Palmer’s “Brain Energy” theory of mental health Why low carb diets are not the solution for anxiety and depression and what to do instead What most people miss when it comes to weight loss and why we shouldn’t focus on fat-burning Strategies to optimally manage blood sugar for Type 1 Diabetes Whether we should lower our fat intake to lose weight Sign up for the Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-109-chris-palmers-brain-energy-type-1-diabetes-and-low-fat-diets-for-weight-loss-qa Timestamps: 0:00 – intro 1:19 – our take on Chris Palmer's “Brain Energy” theory of mental health disorders 5:04 – challenging the misconception of a separation between the brain and body 8:03 – why low-carb, ketogenic, and carnivore diets can produce temporary mental health benefits 10:36 – how impaired energy production underlies poor brain health and how to fix it without using low-carb diets 14:05 – how fat burning can temporarily relieve symptoms of poor glucose utilization (with a major cost) 18:29 – why fatty acid oxidation is our default metabolic state under stress and underlies all chronic disease 22:20 – whether ketogenic diets promote metabolic flexibility 24:53 – poor glucose metabolism as a driver of Alzheimer’s disease and other mental health conditions 28:13 – the adaptive benefit of burning fat during stress 31:31 – blood sugar management for Type 1 Diabetes and whether a low-carb diet is optimal 38:13 – whether lowering fat intake is necessary for burning and losing fat 42:09 – whether improving metabolic function alone is enough to reduce stored fat and when a decrease in dietary fat intake may be necessary 47:32 – the difference between subcutaneous fat and visceral fat and their potential implications 50:34 – how to fix our hunger signals to prevent excessive eating 54:33 – weighing the costs of extreme diets and the need for more innovative thinking around health

In this episode we discuss: The unexpected costs of using excess exercise to lose weight Our thoughts on Herman Pontzer’s book Burn and the Constrained Model of Energy Expenditure Our thoughts on Ted Naiman’s protein to energy ratio diet (PE Diet) The cost of eating too much protein and what to do instead How to increase caloric intake to raise your metabolism and reverse hypothyroidism The major category of nutrients that’s often missed for optimizing mitochondrial function Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-108-herman-pontzers-burn-ted-naimans-pe-diet-and-increasing-calorie-intake-to-raise-metabolism-qa/ Timestamps: 1:25 – Herman Pontzer’s Constrained Model of Energy Expenditure and the adverse effects of energy deficits 7:13 – problems with the additive model of energy expenditure and the physiological cost of excess exercise 10:40 – environmental factors that we can change to increase metabolism 16:42 – the unexpected costs of using excessive exercise to lose weight 19:16 – weight gain as an adaptive response to an energy deficit 22:46 – when eating too much can be a problem and how to identify your ideal calorie intake 32:18 – Ted Naiman’s protein to energy ratio diet and optimal protein intake 41:13 – the problems with using protein as an energy source 46:45 – how to increase caloric intake to raise metabolism and reverse hypothyroidism 50:47 – how to track your symptoms and progress to better guide your nutrient goals 56:55 – the best foods for increasing calorie intake and what to do if you have a low appetite 1:00:30 – the essential role of both macro and micronutrient density in promoting mitochondrial health 1:04:00 – why sugar cravings are not the same as sugar addiction 1:06:46 – easy ways to incorporate more macro and micro nutrient dense foods into your diet

In this episode we discuss: Studies showing that omega-3 consumption decreases lifespan and increases disease processes The potentially harmful effects of omega-3 usage during pregnancy on offspring The impact of omega-3s on inflammation, endotoxin, and mitochondrial respiration The data in native cultures showing that omega-3 intake doesn’t improve cardiovascular disease or mortality Extremely healthy populations that consume high-carb and high-saturated fat diets with almost no omega-3s Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-107-omega-3s-decrease-lifespan-and-increase-disease Timestamps: 0:00 – intro 1:30 – studies showing that omega-3 consumption decreases lifespan and increases disease processes in animals 13:55 – studies on animals showing the harmful effects of omega-3 consumption during pregnancy on offspring 17:37 – studies showing that omega-3 consumption contributes to disease processes, increases inflammation, causes oxidative stress, increases endotoxin, and interferes with mitochondrial respiration 29:23 – whether we should be concerned about saturated fats increasing endotoxin absorption 30:33 – how omega-3 consumption leaves us more susceptible to damage when we’re under stress 33:52 – whether we should be consuming fatty fish 37:00 – the lack of benefit of omega-3 consumption in native populations consuming large amounts of fatty fish and seafood 46:14 – low incidence of cardiovascular disease in native populations consuming very little omega-3s 1:05:18 – concluding thoughts on whether we should consume omega-3s based on the data on omega-3s in RBCs and phospholipids and mortality

In this episode we discuss: Studies showing that fish oil and cod liver oil supplementation increase oxidative damage in humans, even in the triglyceride form alongside antioxidants Why omega-3s are harmful in both healthy and unhealthy humans The harmful metabolic and hormetic effects of omega-3s (and why omega-3s aren’t beneficial due to hormesis) The research showing that omega-3s do not improve chronic health conditions or mortality in humans Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/ Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-106-omega-3s-increase-inflammation-and-oxidative-stress/ Timestamps: 0:00 – intro 1:26 – a summary of the harmful effects of omega-3 consumption in humans 9:14 – omega-3 consumption amplifies the damage from stress (including fasting) 17:08 – vitamin E does not protect against lipid peroxidation from fish oil consumption 20:06 – studies showing that increased omega-3 consumption (including fish oil and cod liver oil) in humans and other animals increases lipid peroxidation, even in triglyceride form 31:45 - how omega-3s triggers hormesis, and why this doesn’t make omega-3s beneficial 39:50 – the context of the omega-3 research and its application 42:57 – studies showing that omega-3 supplementation doesn’t improve chronic health conditions or reduce mortality in humans

In this episode we discuss: Whether the research suggesting that omega-3s decrease mortality is valid Omega-6 intake as a major confounding variable when looking at omega-3 research The dramatic lifespan-lowering effect of omega-3s and total PUFA across all species How omega-3s increase susceptibility to oxidative stress and damage Looking at the Masai diet as an example of a low-omega-3 diet with high omega-3s in the red blood cells Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://jayfeldmanwellness.com/ep-105-challenging-the-idea-that-increased-omega-3-consumption-lowers-mortality/ Timestamps: 0:00 – intro 1:35 – why we’re discussing omega-3s and lifespan 8:10 – the studies showing an association between omega-3 content in phospholipid and reduced mortality 16:48 – conflict of interest as a confounding variable in these studies 18:12 – healthy user bias as a confounding variable in these studies 20:46 – omega-6 consumption as a confounding variable in these studies 29:04 – problems with using RBC phospholipids and serum fatty acids as markers of fatty acid composition of the diet 30:35 – a low omega-6 diet will increase omega-3 content in the RBC phospholipids and serum fatty acids 36:35 – the effect of heritability on RBC phospholipid and serum fatty acid composition 43:58 – the effect of oxidative stress on RBC phospholipid and serum fatty acid composition 52:57 – why it’s important to consider interventional studies and other research to determine whether we should increase omega-3 consumption to reduce mortality 55:30 – research looking at the relationship between composition of phospholipids and lifespan across species 1:07:33 – research looking at the relationship between composition of phospholipids and lifespan within species 1:23:30 – increased consumption of omega-3s increases omega-3 content in phospholipids and therefore the peroxidizability index 1:28:53 – looking at the Masai diet: low omega-6 intake increases omega-3 content in RBC fatty acids

In this episode we discuss: Individualism and competition vs. collaboration and communitarianism Whether humans are inherently selfish and destructive The cost of social media and other forms of distraction How drugs and alcohol can function as numbing agents Why many causes that appear worthy turn out to be distractions from the real problems Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Click here to check out the show notes: https://jayfeldmanwellness.com/ep-104-how-western-culture-keeps-us-distracted-and-fighting-amongst-ourselves/ Timestamps: 1:14 – individualism and competition vs. collaboration and communitarianism 25:45 – randomness, subjectivism, moral relativism, and the resulting nihilism 31:20 – the consequences of the idea that humans are selfish, destructive, and useless other than what we can produce 41:39 – how potentially beneficial advancements become co-opted to maintain the current power structure 48:04 – how western culture degrades esteem and prevents self-actualization 49:43 – the many aspects of modern technology and entertainment that distract us from what’s important 55:26 – how drugs and alcohol can also function as numbing agents 1:03:42 – how worthy causes become co-opted to prevent legitimate progress 1:13:18 – contrasting with cultures that are family-oriented and less distracted by technology 1:16:10 – the effects of culture in science, health, and everyday life

In this episode we discuss: How lower wages and higher costs have dramatically reduced our quality of life How we’ve ended up working more and resting less with worse outcomes Whether advancements in technology have improved the quality of life of the average person How marketing and consumerism keep us on the hamster wheel The hidden costs of convenience culture Concerns surrounding the collusion between government and corporations How divide and conquer tactics convince us to blame each other rather than the powers that oppress us Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-103-how-western-culture-keeps-us-poor-and-destroys-our-family-community-and-relationships/ Timestamps: 1:34 – how western culture degrades safety and security through financial means 7:33 – how lower wages with higher costs reduces safety and forces people to prioritize work over quality of life 15:14 – we currently work more with less leisure time than ever before, with worse outcomes 20:24 – the cost of consumer culture and marketing as an engine that drives consumerism 30:53 – the cost of convenience culture: freedom, privacy, morals, ethics, and health 36:14 – the problems with profit-driven motives and the collusion between government and corporations 45:36 – how western society has become fragile and unstable 51:13 – how western culture degrades relationships and feelings of love and belonging 52:41 – continued how western culture degrades relationships and feelings of love and belonging 53:27 – divide and conquer tactics within western culture and encouraging the “us vs. them” mentality

In this episode we discuss: Why culture matters and how we can effectively navigate it The impact of the diet culture and the “eat less exercise more” paradigm How Western culture blames the individual for their poor health and the toll that this takes The problems with excess work, time indoors, and sedentarism How the modern medical system takes away your capacity to improve your health Why the alternative health sphere can be just as problematic as mainstream medicine Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-102-how-western-culture-mainstream-medicine-keep-us-sick/ Timestamps: 0:00 – why we’re discussing culture and our concerns with the culture in the US and the relationship between culture and health 6:05 – frames through which we can view culture and the importance of Maslow’s hierarchy of needs 13:00 – how western culture degrades health: diet culture and the food industry 27:43 – how western culture degrades health: excess work, time indoors, and sedentarism 34:30 – how easily we can become numb to the effects of our culture or environment 38:07 – the broken modern medical system and the problems with the allopathic, symptom management model 48:21 – problems with the alternative health sphere

In this episode we discuss: Why you want to avoid vegetarian-fed chicken and acorn-fed pork The best bioenergetic fat, protein, and carb sources Why it’s best to avoid salmon and bluefin tuna, and what fish and seafood to have instead Whether we should be including vegetables and fiber in our diet How to avoid vegetable oils and what fats to use instead When it makes sense to include high-FODMAP foods Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-101-building-a-bioenergetic-diet-optimal-carb-fat-and-protein-sources/ Timestamps: 0:00 – intro 1:34 - bioenergetic food guide 2:59 - bioenergetic fat sources 6:20 - bioenergetic protein sources 15:01 - the importance of collagen/gelatin 18:51 - bioenergetic carbohydrate sources 31:25 – foods and additives to avoid 34:15 – experimentation and context as primary components of the bioenergetic view

In this episode we discuss: Optimal macronutrient breakdowns for meals and snacks How to calculate your protein, carbohydrate, and fat needs How to use taste, cravings, hunger, and experimentation to guide your macro intake How to find your starting calorie intake The optimal number of meals and snacks to have in a day Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/ Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-100-building-a-bioenergetic-diet-macros-calories-and-meal-timing/ Timestamps: 0:00 – intro 1:21 – context for these dietary guidelines and the importance of the “why” 7:58 – guidelines for optimal protein intake from the bioenergetic view 14:46 – guidelines for optimal fat intake from the bioenergetic view 29:27 – guidelines for optimal carb intake from the bioenergetic view 31:32 – how to find your starting calorie intake 35:29 – guidelines for optimal carb intake from the bioenergetic view (continued) 42:00 – using taste, cravings, hunger, and experimentation to adjust these guidelines 45:35 – guidelines for optimal meal and snack timing and composition from the bioenergetic view

In this episode we discuss: The problems with using T4-only medications like Synthroid and levothyroxine for hypothyroidism When it makes sense to use thyroid hormone supplements How to use T3, T4, and/or desiccated thyroid (NDT) for hypothyroidism Whether thyroid hormones should be taken away from food due to absorption concerns Whether we should be concerned about thyroid hormone supplementation suppressing our own thyroid hormone production Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-99-medications-supplements-for-hypothyroidism-and-the-problems-with-t4-medications-hypothyroidism-part-5/ Timestamps: 0:00 – intro 1:24 – vitamin and mineral supplementation for thyroid function 5:22 – the context for using thyroid hormone supplementation 7:16 – the problems with using T4-only medications (like Synthroid and levothyroxine) for hypothyroidism 13:58 – evidence that T4 monotherapy is less effective than T3/T4 combination therapy 21:48 – how to use T3, T4, and/or desiccated thyroid (NDT) for hypothyroidism 37:15 – whether thyroid hormones should be taken away from food due to absorption concerns 41:49 – how much is 1 grain of desiccated thyroid? 42:29 – whether thyroid hormone supplements are pharmaceuticals, food, or something in between 44:30 – whether we should be concerned about thyroid hormone supplementation suppressing endogenous thyroid hormone production 46:50 – thyroid hormone supplements in context

In this episode we discuss: How fasting decreases thyroid function Why carbs are essential for thyroid function Specific anti-thyroid foods to avoid Why interventions like cold thermogenesis, caloric restriction, and fasting are not the answer for hypothyroidism The impact of sleep on our thyroid health Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-98-how-to-optimize-your-diet-lifestyle-for-hypothyroidism-hypothyroidism-part-4 Timestamps: 0:00 – intro 1:06 – how to address and reverse hypothyroidism 2:36 – the importance of carbs, calories, and fat for improving thyroid function 16:24 – the importance of eating consistently (and not fasting) for thyroid function 18:00 – saturated fats vs. PUFA and micronutrients for thyroid function 19:45 – basic bioenergetic diet recommendations for hypothyroidism 22:14 – anti-thyroid foods (goitrogens) to avoid 23:08 – other diet considerations when transitioning to a bioenergetic approach 25:56 – low iron in women and excess iron from carnivore or keto diets 27:47 – cruciferous vegetables and thyroid health 28:43 – how to properly address nutrient deficiencies for thyroid health 35:06 – whether stressors like exercise, cold thermogenesis, caloric restriction, and fasting are supportive of thyroid health 47:54 – optimizing sleep for thyroid function

In this episode we discuss: What causes Hashimoto’s hypothyroidism How to properly interpret your thyroid bloodwork (and what your doctor likely doesn’t know about thyroid testing) How your cholesterol values can be used as markers of thyroid status How symptoms like metabolic rate, body temperature, and pulse rate can be more helpful than blood tests when identifying thyroid status Ideal blood test values for optimal thyroid function Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/ Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-97-how-to-properly-test-for-thyroid-function-hypothyroidism-part-3 Timestamps: 0:00 – intro 1:17 – what causes Hashimoto’s hypothyroidism and autoimmunity in general 13:30 – how to interpret thyroid blood tests (TSH, T3, T4, rT3) 31:34 – what reverse T3 means on a blood test and how to interpret rT3 values 34:44 – looking at all thyroid markers together to determine thyroid status 37:05 – the anti-thyroid effects of reverse T3 40:38 – cholesterol levels as a marker of thyroid status, and the problems with cholesterol levels that are too high or too low 52:34 – the relationship between cholesterol, heart disease, and thyroid status 56:04 – other blood markers that can be indicative of thyroid status (SHBG, ferritin) 57:02 – how we can use symptoms like metabolic rate, body temperature, and pulse rate to determine thyroid status 1:12:14 – other symptoms that can be used as indicators of thyroid status (low energy, fatigue, low immune function, dry or cracking skin, hair loss brittle nails, slow motility, weight gain, low mood)

In this episode we discuss: The factors that affect thyroid hormone production, conversion, transport, and uptake How high TSH levels cause damage to the thyroid gland High-carb diets vs. low-carb diets for thyroid health Why restricting calories is not the way to go if you’re struggling with hypothyroidism The effects of PUFA and endotoxin on thyroid hormone activity The problems with both deficiencies and excesses of iron, iodine, and vitamin A for thyroid health Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-96-avoid-low-carb-diets-fasting-and-caloric-restriction-if-you-have-hypothyroidism-hypothyroidism-part-2/ Timestamps: 0:00 – intro 1:28 – the factors that affect thyroid hormone production, conversion, transport, and uptake 3:45 – the impact of stress on thyroid hormone production and conversion 5:02 – how the stress hormones and inflammatory cytokines affect thyroid hormone production and conversion 16:44 – thyroid hormones increase sensitivity to stress hormones 21:44 – elevated free fatty acids, especially PUFA, inhibit thyroid hormone binding 23:26 – how a lack of energy prevents the cells from taking up thyroid hormone 30:00 – how oxidative stress affects thyroid hormone production and the effects of TSH on oxidative stress 38:25 – how a low-carb diet affects thyroid hormone production and conversion, causing a hypothyroid state; high-carb diets vs. low-carb diets for thyroid health 47:46 – insulin resistance is associated with reduced thyroid hormone conversion, but this doesn’t mean you should avoid carbohydrates 51:39 – how caloric restriction affects thyroid status 55:04 – the effects of fasting on thyroid status 56:42 – T3 has positive feedback on its own production and what this means for thyroid hormone replacement 1:00:01 – the effects of PUFA and endotoxin on thyroid hormone activity 1:04:30 – the effects of micronutrients, specifically iron, vitamin A, selenium, and iodine, on thyroid hormone production, conversion, and activity 1:16:30 – increased thyroid activity increases macronutrient and micronutrient needs, but also improves micronutrient retention in the long-term 1:19:15 – the effects of environmental toxins (pesticides, industrial chemicals, heavy metals, etc.) on thyroid hormone production, conversion, and activity 1:25:20 – the effect of sleep on thyroid hormone production and conversion

In this episode we discuss: Why hypothyroidism is not the root cause of your issues Why TSH on its own is not a good marker of thyroid status The importance of thyroid hormones for sex hormone production, gut health, and immune function T3’s effects on autophagy, mitochondrial biogenesis, and uncoupling Whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-95-hypothyroidism-in-context-thyroid-hormone-basics-hypothyroidism-part-1/ Timestamps: 0:00 – intro 1:19 – an introduction to hypothyroidism and common symptoms of hypothyroidism 9:02 – the broader biological context of hypothyroidism and hypothyroidism as a low metabolic state 12:45 – why hypothyroidism is not the root cause 16:23 – the basics of the different thyroid hormones and their regulation 19:54 – the hypothalamic-pituitary-thyroid axis and the nuances within the negative feedback loops 24:45 – the basics of thyroid hormone production 29:37 – the basics of thyroid hormone conversion 35:17 – the larger context of thyroid hormone production and conversion 38:58 – the basics of thyroid hormone transport 41:44 – the basics of thyroid hormone uptake 46:23 – the nutrients involved in thyroid hormone production and conversion 50:26 – the cellular effects of T3 (metabolic stimulation, uncoupling, autophagy, mitochondrial biogenesis, steroidogenesis from cholesterol) 57:29 – the effects of T3 on gut health, immune function, and aging 1:03:08 – whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign 1:08:41 – the relationship between vitamin A and thyroid hormones

In this episode we discuss: Why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling The involvement of uncoupling, mitochondrial biogenesis, autophagy, heat shock proteins, and hypoxia-inducible factors in the stress response How stress prevents our mitochondria from effectively producing energy How chronic stress causes insulin resistance, high blood pressure, weight gain, depression, and cardiovascular disease How sugar and fat cravings result from stress and why listening to them is beneficial How adaptations to stress get passed on through generations Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/ Timestamps: 0:00 – intro 2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids 6:05 – the short-term effects of catecholamines 8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling 14:40 – the protective effects of uncoupling as a part of the stress response 20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response 37:33 – the effect of acute stress on energy production in mitochondria 45:18– the effect of chronic stress on energy production in mitochondria 48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states 1:05:24 – the relationship between mental health, mood, and metabolic function 1:10:21 – how adaptations to stress get passed on through mitochondrial DNA 1:18:32 – how to best improve mitochondrial function and our health

In this episode we discuss: Why stress is not your friend The effects of cortisol on your mitochondria Hans Selye’s general adaptation syndrome How cortisol causes mitochondrial dysfunction, heart disease, insulin resistance, autoimmunity, allergies & hypersensitivity, mineral imbalances, and cancer metabolism Why acute stress does not lead to improved health via hormesis Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-93-how-cortisol-affects-your-mitochondria-acute-vs-chronic-stress-stress-mitochondria-part-1-ep-93/ Timestamps: 3:00 – an introduction to the paper: mitochondria as key components of the stress response 4:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance 23:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response 31:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts 34:04 – how long-term stress causes degeneration 34:55 – functions of the mitochondria 38:54 – mitochondria upregulate energy production in response to stress 41:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol) 44:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time 50:30 – how mitochondria respond to excess stress and how this relates to fat gain 59:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-92-celebrating-ray-peat/ Ray Peat's Website: http://raypeat.com/ Ray Peat Interviews, Articles, Related Websites, and Other Resources: https://www.selftestable.com/ray-peat-stuff/sites

In this episode we discuss: Whether cod liver oil is an ideal source of vitamin A/retinol Whether we should be concerned about the omega-3 content of cod liver oil (CLO) The idea that we want our fat cells to be insulin resistant to lose fat Whether keeping insulin low is the key to fat loss What hormones regulate fat loss Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-91-cod-liver-oil-dangers-the-croissant-diet-and-insulin-resistant-fat-cells-q-a/ Timestamps: 2:54 – what we think about cod liver oil as a vitamin A source 9:50 – why someone may benefit from cod liver oil, and why it likely isn’t a result of the retinol 10:56 – the immunosuppressive effects of omega-3s 14:25 – the major problems with omega-3s, including cod liver oil specifically 25:33 – clarifying our thoughts on the Croissant Diet 28:26 – burning saturated fat versus burning PUFA and whether PUFA create more ROS than saturated fats 31:41 – what we think of the idea that consuming saturated fats will allow for fat loss by causing insulin resistance in the adipocytes (fat cells) 42:50 – why increasing fat burning doesn’t inherently lead to increased fat loss 47:11 – whether increasing satiety is the key to fat loss

In this episode we discuss: Whether fish oil is beneficial due to its anti-inflammatory and cholesterol-lowering effects Our thoughts on the benefits from a paleo-ketogenic diet What to do if you’re dealing with dental issues from sugar consumption Our experiences eating 5,000 to 6,000 calories per day The best time to eat the carrot salad Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-90-eating-5000-calories-per-day-fish-oil-water-weight-vs-body-fat-paleo-ketogenic-diet-q-a/ Timestamps: 2:44 – why fish oil shows anti-inflammatory and cholesterol-lowering effects, and why this doesn’t mean they’re beneficial 11:25 – eating carrots with a meal versus away from a meal 17:27 – our thoughts on the benefits from a paleo-ketogenic diet 28:45 – which coral calcium supplement we recommend 32:33 – dental issues from sugar consumption 39:45 – what we think of orange juice with added calcium 41:36 – how to determine whether weight gain is due to water weight or body fat 51:57 – our experiences eating 5,000-6,000 calories per day 1:03:23 – whether it’s helpful to use calorie calculators and context to consider when it comes to calorie calculators 1:11:20 – how our current diets vary in contrast to when we were eating 5,000-6,000 calories per day

In this episode we discuss: Whether PUFA causes more oxidative stress than saturated fats How PUFA intake affects testosterone Whether fruit juice should be avoided for blood sugar regulation The effects of fruit juice on inflammatory markers and endotoxin Whether fruit juice has the same effects as soda Check out the Energy Balance Solution group coaching program: https://jayfeldmanwellness.com/solution Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-89-the-anti-inflammatory-effects-of-fruit-juice-and-the-hormonal-effects-of-pufa-vs-sfa/ Timestamps: 4:10 – the effects of different dietary fat compositions on phospholipid and neutral lipid compositions in the testicles 18:31 – the effects of different dietary fat composition on oxidative damage and antioxidant status in the testicles 29:44 – the effects of different dietary fat composition on hormone production and metabolism in the testicles 38:26 – introducing the next study discussing the effects of orange juice on a high-fat, high-carbohydrate meal in terms of inflammation and endotoxin 44:14 – the effects of orange juice on blood glucose and insulin sensitivity 47:55 – the effects of orange juice on ROS production, TLR2 and TLR4 expression, and plasma endotoxin 51:35 – factors that could account for the benefits of orange juice

In this episode we discuss: The hormonal effects of compounds in soy How the effects of BPA compare to soy Whether soy is estrogenic and causes infertility Whether the amount of soy typically consumed is sufficient to create these effects Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-88-whether-soy-is-estrogenic-and-causes-infertility/ Timestamps: 3:06 – overview of the study we’ll be discussing 5:57 – compounds in soy have potentially estrogenic thymic, immune, and hormonal effects 10:20 – compounds in soy oppose testosterone and reduce its production 13:33 – whether animal research translates to humans 16:40 – BPA has anti-fertility effects in males that are parallel to supplemental estrogen 27:39 – corn oil causes weight gain despite the same number of calories consumed 32:11 – the reproductive effects of soy, BPA, and estradiol 44:50 – the amount of soy required to cause these reproductive effects

In this episode we discuss: Whether low-carb diets increase cortisol over time How the bioenergetic view incorporates evolutionary biology, and how this differs from the ancestral health model Whether tolerance to stress is improved on low-carb diets Why being overweight or obese is not a sign of excess energy What we think of Paul Saladino’s interpretation of the “Ray Peat Diet” Check out the Energy Balance Solution group coaching program: https://jayfeldmanwellness.com/solution Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-87-robb-wolf-on-ray-peat-and-the-bioenergetic-view-energy-obesity-evolution-and-paul-saladino/ Timestamps: 4:22 – how low-carb diets increase stress hormones and increase susceptibility to stress 22:32 – why being overweight or obese is not a sign of excess energy 34:20 – whether the bioenergetic view ignores evolutionary biology 49:30 – what we think of Paul Saladino’s interpretation of the “Ray Peat Diet”

In this episode we discuss: Whether it’s stressful to be in a fat-burning, keto-adapted state How blood sugar is regulated when we’re not eating carbohydrates, and how this impacts stress hormones and thyroid hormones Whether having stable blood sugar levels on a low-carb diet is a good thing The problems with elevated levels of glucagon, which occurs when someone is on a low-carb diet Why glucagon is a stress hormone and its impact on thyroid hormones Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-86-robb-wolf-on-ray-peat-and-the-bioenergetic-view-stress-blood-sugar/ Timestamps: 4:30 – why we wanted to discuss Robb Wolf’s perspective of the bioenergetic view 8:25 – Robb’s main points against the bioenergetic view 9:52 – whether fat-burning and being keto-adapted is stressful and how blood sugar is regulated in these states 31:29 – the problems with elevated levels of glucagon, which occurs when someone is on a low-carb diet

In this episode we discuss: Whether we should be avoiding fructose-containing foods due to their potential to increase uric acid Whether the fact that we lack uricase means that we shouldn’t be consuming fructose- containing foods The role of endotoxin and gut health in uric acid production and gout Which fructose sources are ideal for metabolic health How to adjust fructose intake if someone is dealing with insulin resistance, non-alcoholic fatty liver disease, or gout Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-85-fructose-and-uric-acid-are-david-perlmutter-and-rick-johnson-wrong-part-2/ Timestamps: 3:42 – whether our lack of uricase is reason for us not to consume fructose 33:23 – whether we should be avoiding fructose-containing foods like fruit due to their potential to increase uric acid production 46:25 – the role of endotoxin and gut health in uric acid production and gout 53:12 – ideal fructose sources and how to adjust fructose intake if someone is dealing with insulin resistance, non-alcoholic fatty liver disease, or gout

In this episode we discuss: Whether David Perlmutter and Rick Johnson are right about fructose and uric acid being drivers of poor metabolic health Why fructose will not cause ATP depletion when it’s consumed in normal contexts Why fructose and uric acid are not the drivers of metabolic syndrome and degenerative conditions The protective effects of fructose in the liver Why it’s extremely important to consider the different contexts in which uric acid is produced Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-84-fructose-and-uric-acid-are-david-perlmutter-and-rick-johnson-wrong-part-1/ Timestamps: 3:56 – why we’re discussing fructose and uric acid 8:38 – the general argument that fructose consumption drives uric acid production and that this is responsible for disease and degeneration 14:48 – our general counterargument that fructose consumption does not drive disease and degeneration via uric acid production 18:41 – whether fructose depletes ATP in the liver 30:03 – fructose is extremely protective and generally increases ATP availability in the liver 36:27 – how fructose can increase uric acid via ATP depletion 38:51 – why fructose doesn’t cause ATP depletion and uric acid production unless it’s given in extreme, non-physiologically relevant contexts 1:04:50 – whether uric acid is the driver of metabolic syndrome and many degenerative conditions by driving oxidative stress 1:15:46 – why xanthine oxidase is a major confounding variable to consider when evaluating whether uric acid production is harmful 1:27:02 – whether the activation of AMP deaminase is a reason not to consume fructose 1:27:55 – average fructose intakes are far below the amounts that are typically used in research

In this episode we discuss: How our bodies partition nutrients and why this matters for optimizing our health Why hyperpalatable food and stress-eating are not the primary drivers of overeating How being sedentary can mimic starvation and excess stress How excessive fat-burning causes metabolic derangement and overeating Why an energetic deficit is not required for fat loss and instead causes fat gain Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-83-how-nutrient-partitioning-affects-eating-behavior-and-fat-loss/ Timestamps: 2:48 – overview of the study we’ll be discussing 6:21 – why excess energy and overeating don’t cause fat gain 13:59 – the flow of energy through our metabolic systems determines health 18:25 – insulin resistance is an adaptive process that allows for nutrient partitioning 22:31 – insulin resistance occurs in stress states, such as caloric restriction, fasting, and low-carb diets, to divert fuel to the most essential tissues 29:24 – hunger and appetite are determined by the amount of energy available, not number of calories taken in 47:46 – physical inactivity results in the same harmful metabolic effects as starvation and excess exercise 56:31 – hyperpalatable sugar- and fat-containing foods do not cause obesity 1:00:26 – other factors that affect nutrient partitioning 1:09:46 – considerations to keep in mind when reading and evaluating research 1:13:35 – why an energetic deficit is not required for fat loss

In this episode we discuss: Supplements to maximize fitness and athletic performance Why exercise and physical fitness are generally beneficial as long as they’re kept in the right balance The minimum effective doses for muscle growth, strength, and endurance How stress and sleep affect our capacity to handle exercise Nutritional strategies to mitigate the harmful stress effects from high levels of exercise while maximizing performance Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-82-maximizing-fitness-and-athletic-performance-from-the-bioenergetic-view-fitness-vs-health-part-3/ Timestamps: 2:44 – why exercise and physical fitness are generally beneficial as long as they’re kept in balance 14:43 – the limits to our metabolic capacity and how this relates to exercise 29:47 – nutritional strategies to mitigate the harmful stress effects from high levels of exercise while maximizing performance 39:32 – addressing sleep and stress to mitigate the harmful stress effects from high levels of exercise while maximizing performance 45:18 – supplements to mitigate the harmful stress effects from high levels of exercise while maximizing performance 1:06:46 – concluding thoughts related to maximizing fitness and athletic performance from the bioenergetic view

In this episode we discuss: How to determine how much exercise is right for you Why working out regularly is not enough to make up for sitting all day Why fitness and health are not synonymous Whether lactic acid production, breathlessness, and fat oxidation due to exercise should be avoided at all costs Whether intense exercise and being highly active is always more harmful than helpful Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-81-whether-intense-exercise-and-endurance-training-should-be-avoided-fitness-vs-health-part-2/ Timestamps: 2:55 – the benefits of movement and exercise 6:41 – whether intense exercise involving lactate production and heavy breathing/breathlessness is harmful 10:13 – whether endurance training involving fat oxidation is harmful 18:31 – drawing a line between fitness and health 25:06 – how to determine how much exercise is right for you 38:23 – whether intense exercise and being highly active is always more harmful than helpful 43:33 – why “eat less and exercise more” doesn’t work and ignores major aspects of our physiology

In this episode we discuss: The harmful effects of excess exercise Why increasing exercise beyond moderate amounts is NOT effective for weight loss The harmful effects of excessive endurance training on cardiovascular health How excess exercise can drive degeneration and contribute to various health issues How much exercise is “too much” Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-80-how-much-exercise-is-too-much-from-the-bioenergetic-view-fitness-vs-health-part-1/ Timestamps: 2:37 – framing the question of where health and fitness meet from the bioenergetic view 13:12 – how excess exercise can cause degeneration and contribute to various health conditions 21:03 – what level of exercise is harmful for cardiovascular health 29:55 – how the expensive tissue hypothesis applies to exercise 45:14 – how excess exercise can steal energy from other areas of our physiology, and how this affects the calorie equation 1:08:23 - can moderate-intensity endurance training for 25 minutes 3 days per week be too much?

In this episode we discuss: Whether it’s beneficial to force increased mitochondrial respiration with supplements How to determine the ideal amount of pro-metabolic supplements to take What to do if you react poorly to collagen or gelatin protein powder Whether food additives like carrageenan, gums, nitrates, sorbates, MSG, microbial enzymes, cultures, and artificial colors are worth avoiding Whether we need to be concerned about hyperthyroidism and whether hyperthyroidism can be caused by over-supplementing thyroid hormone Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-79-hyperthyroidism-collagen-alternatives-and-forcing-mitochondrial-respiration-q-a/ Timestamps: 2:39 – is it beneficial to “force” increased mitochondrial respiration and the oxidation of glucose 15:09 – alternatives to collagen or gelatin protein powder 19:19 – which food additives are worth avoiding 58:53 – whether hyperthyroidism is something we should be concerned about

In this episode we discuss: How you can induce mitochondrial biogenesis and uncoupling without stress Why you want tighter mitochondrial coupling if you want to induce uncoupling in a healthy way The difference between reactive oxygen species production in a high energy state versus a low energy state How many supposedly hormetic interventions, like exercise, fasting, and ketogenic diets, can be beneficial despite the stress they cause rather than because of it How the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view What anti-hormesis looks like in a practical sense Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-78-why-maximizing-energy-production-and-minimizing-stress-is-optimal-for-health-hormesis-part-4/ Timestamps: 3:22 – the difference between producing ROS in a high energy state compared to a low energy state 9:38 – how ATP protects against oxidative stress 21:55 – how CO2 protects against oxidative stress 26:31 – how tighter mitochondrial coupling is better for inducing uncoupling 27:48 – the broader context of why we want to adapt to a high-energy, low-stress state 33:28 – how exercise can be beneficial despite the stress it causes, rather than because of it 47:06 – how low-carb/ketogenic diets can be beneficial despite the stress they cause, rather than because of it 57:40 – what to expect when moving away from a hormetic approach 1:02:16 – how the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view 1:03:39 – what anti-hormesis looks like in a practical sense

In this episode we discuss: Why the stress caused by calorie restriction, exercise, cold thermogenesis, fasting, ketogenic diets, Wim Hoff breathing, and supplements like resveratrol is not supportive of our health Why autophagy, mitochondrial biogenesis, and uncoupling are not always beneficial Whether being tolerant to stress is a sign of health Why it’s virtually impossible to apply hormesis in a practical sense The difference between reactive oxygen species production in a high energy state versus a low energy state Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-77-why-you-dont-want-to-force-autophagy-mitochondrial-biogenesis-uncoupling-hormesis-part-3/ Timestamps: 3:27 – why reductions in adaptive responses in degenerative states and the benefits of “hormetic” interventions does not lend support to hormesis 13:49 – why improving tolerance to stress is not inherently beneficial and the cost of stress across generations 28:58 – how the fact that stress is cumulative throws a wrench in the idea of hormesis 37:05 –the difference between producing ROS in a high energy state versus a low energy state 49:16 – the low energy, high ROS state is a feature of degenerative conditions

In this episode we discuss: How the largest body of evidence cited in favor of hormesis actually doesn’t support it at all Why caloric restriction is NOT responsible for slowing aging and extending lifespan (and what is actually responsible) The many factors that confound the calorie restriction research (including differences between organisms, poor research design, amino acid restriction, PUFA, endotoxin, and more) Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-76-why-caloric-restriction-is-not-responsible-for-lifespan-extension-hormesis-part-2/ Timestamps: 3:36 – the physiology of hormesis and the general support for hormesis 12:54 – outlining the problems with hormesis 18:51 – how differences between organisms confound the caloric restriction research 37:34 – the problem with using proxy markers to evaluate health effects and the importance of context 48:20 – how differences between organisms confound the caloric restriction research (cont.) 51:58 – how hydration status and macronutrient ratios confound the caloric restriction research 55:57 – how the myopic hormetic view leads to the ignorance of many confounding variables 1:02:00 – how the restriction of particular amino acids, ad libitum feeding, and a refined diet confound the caloric restriction research 1:11:58 – how PUFA confounds the caloric restriction research 1:30:09 – how endotoxin and gut health confound the caloric restriction research

In this episode we discuss: How the concept of hormesis defends our exposure to toxic chemicals, industrial contaminants and pollutants, and ionizing radiation Why hormesis is a dangerous, anti-scientific idea masquerading as science The suspicious history of hormesis and its current definitional problems The important distinction between stress and adaption The problems with the terms “eustress” and “distress” Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy Click here to check out the show notes: https://jayfeldmanwellness.com/ep-75-hormesis-as-an-anti-scientific-defense-for-industrial-pollution-and-chemical-exposure-hormesis-part-1/ Timestamps: 3:36 – an introduction to hormesis as a means to reverse aging and reverse chronic health conditions 6:45 – what is hormesis 12:34 – the suspicious history of hormesis 16:20 – the definitional problems with hormesis 34:51 – how hormesis is influencing dangerous public health policies 47:35 – the difference between stressor effects and specific effects, creating a distinction between stress and adaptation, and the problems with the terms “eustress” and “distress”