EB. 120: Vitamin A Toxicity: Retinoic Acid Toxicity, Accutane, and Whether Hypervitaminosis A Exists
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Show Notes
- The research behind vitamin A toxicity and whether vitamin A is really a poison
- Whether you need to be concerned about the use of Accutane
- Whether retinoic acid is toxic because it’s used as a chemotherapeutic agent
- Whether Grant Genereux’s claims about vitamin A toxicity are valid
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0:00 – intro
1:15 – why we're examining Grant Genereux's take on vitamin A toxicity and the evidence behind his claims
4:50 – conceptualizing the amount of vitamin A needed for toxicity
7:07 – is hypervitaminosis A (vitamin A toxicity) real?
9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis
12:36 – is there a conspiracy to poison the masses with vitamin A?
18:36 – how likely is it that you have vitamin A toxicity?
22:30 – problems with the first in vivo study that Grant uses to support vitamin A toxicity
35:14 – vitamin A toxicity in the studies Grant cited require massive doses of vitamin A that would be impossible to obtain from diet
42:44 – Grant’s cited research actually supports the safety of vitamin A
50:52 – more of Grant’s cited research supporting vitamin A safety
58:25 – further research supporting that extremely high doses are required to cause vitamin A toxicity
1:07:57 – whether vitamin A toxicity is driving autoimmunity
1:09:54 – whether retinoic acid is toxic based on concerns regarding the use of Accutane
1:15:40 – how conflating Accutane with retinoic acid is misleading
1:22:12 – whether retinoic acid is toxic because Accutane is used as a chemotherapeutic agent
1:29:37 – evaluating Grant’s claim that retinol automatically becomes “toxic” retinoic acid
1:35:05 – our concluding thoughts on Grant’s arguments regarding vitamin A toxicity