In this episode we discuss:
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Why stress is not your friend
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The effects of cortisol on your mitochondria
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Hans Selye’s general adaptation syndrome
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How cortisol causes mitochondrial dysfunction, heart disease, insulin resistance, autoimmunity, allergies & hypersensitivity, mineral imbalances, and cancer metabolism
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Why acute stress does not lead to improved health via hormesis
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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-93-how-cortisol-affects-your-mitochondria-acute-vs-chronic-stress-stress-mitochondria-part-1-ep-93/
Timestamps:
3:00 – an introduction to the paper: mitochondria as key components of the stress response
4:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance
23:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response
31:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts
34:04 – how long-term stress causes degeneration
34:55 – functions of the mitochondria
38:54 – mitochondria upregulate energy production in response to stress
41:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol)
44:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time
50:30 – how mitochondria respond to excess stress and how this relates to fat gain
59:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism
