Longevity Roadmap

In this conversation, Buck and Dr. Nicola Conlon delve into the significance of NAD (Nicotinamide Adenine Dinucleotide) in aging and longevity. Dr. Conlon explains the role of NAD in cellular energy production, its decline with age, and the consequences of this decline on cellular repair and overall health. They discuss the importance of NAD in activating sirtuins, which are crucial for longevity, and explore the limitations of direct NAD infusions. The conversation concludes with insights into NAD precursors like NMN and NR, which can help increase NAD levels in the body. Dr. Conlon is offering our listeners a special 20% discount on first purchase at www.nuchido.com. Use the code SAPIO20.

Buck and Nikki sit down with Dan Buettner, creator of the Netflix series Live to 100: Secrets of the Blue Zones, to explore the wisdom of the world's longest-lived populations. They dive into the lifestyle, diet, and environmental factors that contribute to longevity, and how you can engineer these principles to extend your healthy lifespan.

This week on Longevity Roadmap, Buck showcases standout moments from Longevity Junky—another health-focused podcast he co-hosts with actress and model Nikki Leigh. Designed for a broader audience, Longevity Junky makes longevity concepts accessible while delivering valuable insights. Tune in for a curated selection of engaging topics, complete with Buck's commentary, offering fresh perspectives not covered on Longevity Roadmap.

Buck Joffrey interviews Martin Gibala, a professor at McMaster University, about High-Intensity Interval Training (HIIT) and its benefits. They discuss the definition of HIIT, its physiological mechanisms, and how it compares to traditional exercise. The conversation also covers the implications of HIIT for different populations, its connection to VO2 max and longevity, practical applications in daily life, safety considerations, and resources for further learning. 00:00 - Introduction to High-Intensity Interval Training (HIIT) 04:39 - Physiological Mechanisms of HIIT vs. Traditional Exercise 08:34 - HIIT for Different Populations and Health Benefits 12:30 - VO2 Max and Longevity: The HIIT Connection 16:30 - Practical Applications of HIIT in Daily Life 20:37 - Safety and Considerations for HIIT Training 24:31 - Conclusion and Resources for Further Learning

In this wholesome conversation, Buck and Dr. Ellen Langer discuss the profound connection between the mind and body, emphasizing the importance of mindfulness in health and aging. She shares insights from her groundbreaking studies, including the counterclockwise study, which demonstrated that altering one's mindset can lead to significant health improvements. The discussion also explores how perception influences physical attributes, the detrimental effects of mindlessness, and the potential for mindfulness to enhance longevity and overall well-being. 00:00 - The Mind-Body Connection and Health Paradigms 06:08 - Perception and Health: The Power of Mindset 12:09 - Mindlessness: The Root of Our Problems 19:36 - Understanding Mindfulness 27:52 - The Power of Placebo 36:20 - Harnessing Mindfulness for Longevity

In this episode, Buck Joffrey discusses the importance of going beyond the normal scope of testing when it comes to lipid profiles and cardiovascular health management. He emphasizes the significance of understanding cholesterol particles, particularly APO-B, and lipoprotein(a), in assessing heart disease risk. He also highlights preventative strategies to optimize health and mitigate risks associated with cardiovascular disease.

In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for proactive treatment strategies. 00:00 - Introduction to Longevity Roadmap 03:08 - Case Study: A 70-Year-Old Patient's Health 12:07 - Understanding Lipid Management and Atherosclerosis 19:49 - Genetic Factors in Alzheimer's Risk and Lipid Management

Hey Sapio Fans, I've got something really exciting for you today—a chance to win a full-body MRI worth $2,500! This giveaway comes from my new podcast, Longevity Junky (that's junky with a Y). It's a fun, insightful show I co-host with actress Nikki Leigh, where we dive into cutting-edge advancements in health and longevity. This week's episode is all about full-body MRIs from Prenuvo, a groundbreaking technology that can identify over 500 conditions—including deadly cancers and brain aneurysms—before they pose a serious threat to your health. Here's how you can enter to win this $2,500 Prenuvo MRI scan for free: Go to Apple Podcasts and find the Longevity Junky podcast (that's "Junky" with a Y). Leave a five-star review for the podcast. Subscribe to the podcast. Take a screenshot of your review. Visit LongevityJunky.com (again, "Junky" with a Y). Send the screenshot of your review along with a brief explanation of why you'd like a full-body MRI. Winners will be announced in 2 weeks—stay tuned and good luck to everyone!

An interview with Aubrey de Grey, a founding father of the longevity movement—the man who coined the phrase 'Longevity Escape Velocity.' Aubrey discusses the transformative potential of damage repair, stem cell therapies, and advancements that are turning science fiction into reality. From reversing cellular damage to extending health spans by decades, this conversation unpacks his cutting-edge research and bold predictions shaping the longevity landscape. Tune in to explore a future where living to 1000 might just be possible.

This Black Friday and Cyber Monday, I want to share something truly meaningful—the opportunity to invest in your health or the health of someone you love. The Longevity Roadmap Course has already transformed lives, uncovering critical health issues and empowering participants to reverse conditions like borderline diabetes and optimize their health. It's no exaggeration to say this course has already saved years of good-quality life. This year, why not give the ultimate gift—the gift of health and time? Imagine helping a loved one discover a brighter, healthier future with a life-changing resource tailored to empower them for decades to come. Black Friday & Cyber Monday Special: For a limited time, I'm offering 20% off the Longevity Roadmap Course, which includes three months of biweekly one-on-one coaching with me. This offer is good through Cyber Monday, so don't wait—act now! The tools, science, and coaching included in this course can: Help prevent or reverse common conditions like heart disease and diabetes. Unlock strategies to add years of vibrant, good-quality life. Give peace of mind knowing you or your loved one is on the best path forward. This isn't just an investment in health—it's an investment in time with the people who matter most. Make this holiday season truly unforgettable by giving a gift that will last a lifetime—or longer. Sign Up Now and Use the Coupon Code Blackfriday2024 at Checkout to Get 20% Off – Offer Ends Cyber Monday! Here's to a longer, healthier, and happier future—for you and your loved ones. – Buck P.S. Want to learn more? Book a call with me on longevityroadmap.com and let's talk!

Buck interviews Mark Mortenson and Rob Etherington from Clene Nanomedicine, discussing their innovative approach to treating neurodegenerative diseases using clean surface nanocrystals. They delve into the science behind nanoparticles, their role in enhancing mitochondrial function, and the mechanisms of neurorepair. They also cover clinical applications, safety considerations, and the challenges in bringing their nanomedicine to market.

In this episode, Buck dives into the groundbreaking work of Dr. David Raubenheimer and Professor Stephen Simpson, renowned nutritional scientists from the University of Sydney. They unpack the "Geometric Framework for Nutrition," a holistic and visual approach that examines how nutrients interact to shape health and aging. From protein leverage to balancing macronutrients for longevity, this conversation challenges conventional calorie counting and offers profound insights into optimizing diet across the lifespan.

Buck and Prof Glen Jeffery dive deep into the science of red light therapy, revealing how it boosts mitochondrial function and potentially slows aging. He shares groundbreaking insights from clinical trials, showing how red light can recharge cellular energy and improve vision health. We get into practical tips on using red light therapy—where to get it, when to use it, and what to watch out for in devices.

Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced understanding of lipid management. The discussion also covers key lab tests, the significance of apolipoprotein B, and the future of pharmacotherapy in lipid management. 04:51 Understanding Cholesterol: Beyond Good and Bad 08:25 Key Lab Tests for Lipid Management 11:12 The Role of Apolipoprotein B in Cardiovascular Health 14:44 The Complexities of HDL and Its Functions 19:11 The Misconceptions Around LDL and HDL Ratios 34:42 Pharmacotherapy: Statins and Beyond

Dr. Diogo Barardo, Director of Research and Development at Novos, joins Buck to discuss Novos' innovative approach to longevity supplements, unpacking the differences between biological and epigenetic aging and the impact of the Drug Age database. He details how Novos evaluates compounds for safety and efficacy, the unique ingredients in their flagship NovoScore, and the promising roles of lithium microdoses and NAD precursors. Their conversation also delves into the latest in longevity science, from the controversies around resveratrol to mitophagy's role in cellular health, the complexities of supplement dosages, and the potential of aging biomarkers and AI-driven research for consumer longevity solutions. Learn more about Dr. Barardo and NOVOS: https://novoslabs.com/ 00:00 Introduction to Longevity Research and Novos 02:04 Understanding Biological and Epigenetic Aging 09:20 The Drug Age Database and Its Significance 10:37 Longevity Compounds and Their Efficacy 20:58 The Role of Lithium and NAD Precursors 26:44 The Role of Mitochondria in Aging 36:14 Leveraging AI in Longevity Research

Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body's nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there's a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity. 00:00 The Role of Nitric Oxide in Human Physiology 02:54 Age-Related Decline of Nitric Oxide and Cardiovascular Health 05:49 Understanding Nitric Oxide Production Pathways 09:03 The Impact of Oral Health on Nitric Oxide Levels 12:11 Proton Pump Inhibitors and Their Effects on Nitric Oxide 15:12 Pharmaceutical Approaches to Increase Nitric Oxide 18:03 Innovations in Nitric Oxide Delivery Systems 21:25 The Role of Nitric Oxide as a Hormone 23:02 Nitric Oxide in COVID-19 Treatment 25:58 MTHFR Gene and Nitric Oxide Production 29:05 Cardiovascular Disease and Nitric Oxide 31:53 Safety and Regulation of Nitric Oxide 34:05 Cholesterol Myths and Nitric Oxide's Importance

Buck speaks to Dr. Torkil Færø, a Norwegian general practitioner, emergency physician, and seasoned traveler with Doctors Without Borders, to discuss the crucial relationship between stress, heart rate variability (HRV), and overall health. Dr. Færø delves into how HRV serves as a key indicator of our body's autonomic nervous system balance, showing how lifestyle factors, particularly chronic stress, can undermine well-being. He highlights practical strategies, from breathwork to dietary adjustments, aimed at optimizing HRV and promoting long-term health. 00:12 What is Heart Rate Variability? 05:34 The Normal Range of HRV 08:39 Contributing Factors that Impact Your HRV 23:18 Tactics to Improve HRV

Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressing the potential challenges posed by medications like statins and conditions such as long COVID. 02:07 What are Mitochondria? 05:05 Mitochondrial Dysfunction and Aging 12:13 Mitochondrial Genetics and Inheritance 14:54 Innovative Approaches to Mitochondrial Health 17:58 Pharmaceuticals and Supplements for Mitochondrial Support

Buck delves into the pervasive issue of microplastics, exploring their sources, health risks, and potential strategies for detoxification and exposure reduction. He discusses how microplastics infiltrate our food, water, and air, and the alarming health implications they pose, including chronic inflammation and potential links to cancer, as well as practical steps to minimize exposure to microplastics in daily life.

In this episode of Longevity Junky, Buck and Nikki tackle one of the most contentious and polarizing areas of longevity, diet with Bio Layne founder Dr. Layne Norton. Learn more about BioLayne and Dr. Layne Norton: https://biolayne.com/coach/layne-norton/ Full episode in video available on YouTube: https://www.youtube.com/channel/UCh6LlBjtOy7lldU7Ldjw0cw Questions? Send us a message at: www.longevityjunky.com Follow us on social media: Instagram: https://www.instagram.com/longevityjunkypodcast Facebook: https://www.facebook.com/profile.php?id=61564965475593 Twitter: https://x.com/longevity_junky Tiktok: https://www.tiktok.com/@longevityjunkypodcast

Buck introduces his brand new podcast, Longevity Junky. In this episode of Longevity Junky, Buck and co-host Nikki Leigh sit down with renowned psychiatrist and brain disorder specialist, Dr. Daniel Amen, founder of Amen Clinics, to discuss groundbreaking brain imaging techniques like SPECT scans. Dr. Amen shares insights on diagnosing mental health issues through brain mapping and the role of brain health in overall longevity.

Dr. Susan Jackson discusses the concept of flow and its impact on quality of life and performance. Flow is an optimal psychological state where individuals are fully focused on a task and experience a loss of self-consciousness. It enhances the quality of our experience and can positively shape the quality of our lives. Flow can be experienced in various domains, including sports, creativity, and everyday activities. Mindfulness meditation can help access flow by improving focus and attention. The book 'Experiencing Flow' explores the relationship between mindfulness and flow and provides practical strategies for accessing flow in daily life. 00:13 The Definition of Flow 04:05 How Do We Have Flow? 08:25 Gettign In and Out of Flow 14:07 Mindfulness vs Flow

Buck shares his recent experience with a retinal tear and detachment, emphasizing the importance of early diagnosis and treatment to prevent permanent vision loss. He explains the anatomy of the eye, the process of vitreous detachment, and the symptoms of retinal tear and detachment. Buck also discusses the risk factors for these conditions, including high myopia and previous eye surgery. He describes his surgical experience and the use of a gas bubble to reattach the retina.

Buck discusses the role of big Tech and the elderly with Keren Etkin, founder of TheGerontechnologist.com. Discussion includes the role of robots, implications for social interaction, as well as the additional opportunities for founders to take advantage of the coming geriatric storm. 01:04 Current Tech for Aging 05:17 Tech for Social-Emotional Support 09:03 The Driving Force Behind the Development 12:00 The Impact of Increasing Longevity 13:54 Affordability of Aging Tech 17:08 Cyborgification

Link to Buck's Results: https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing Section 1: Overview of Cholesterol Metabolism Cholesterol in the Body: Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production. It is produced endogenously in the liver and absorbed exogenously from dietary sources. Endogenous Production: Cholesterol is synthesized in the liver through the mevalonate pathway. Key intermediates: Lathosterol and Desmosterol, indicators of cholesterol production rate. Exogenous Absorption: Dietary cholesterol is absorbed in the intestines along with plant sterols like Beta-sitosterol and Campesterol. These sterols compete with cholesterol for absorption, reflecting dietary cholesterol absorption levels. Section 2: Detailed Analysis of the Test Components Production Markers: Lathosterol: Precursor in the cholesterol biosynthesis pathway. Elevated levels indicate increased hepatic cholesterol synthesis (overproduction). Example: Lathosterol level of 329 µmol x 100/mmol in my study indicates hyperactive cholesterol production. Desmosterol: Another precursor in the synthesis pathway, contributing to total cholesterol production. High levels reinforce the diagnosis of increased cholesterol production. Example: Desmosterol level of 74 µmol x 100/mmol in my study supports elevated production. Absorption Markers: Beta-sitosterol: Plant sterol absorbed in the intestines, competes with cholesterol. High levels suggest increased absorption of dietary cholesterol. Example: Beta-sitosterol level of 120 µmol x 100/mmol indicates borderline absorption. Campesterol: Similar to Beta-sitosterol, reflects cholesterol absorption efficiency. Elevated levels indicate increased absorption. Example: Campesterol level of 113 µmol x 100/mmol within normal limits but suggests absorption could be a factor. Cholesterol Balance Score: Ratio of production to absorption markers. A higher score indicates predominant cholesterol production; a lower score indicates absorption as the main issue. Example: Score of 2.4 suggests overproduction is the dominant issue. Section 3: Clinical Implications and Treatment Strategies Frequency of Overproduction vs. Overabsorption: Common to see patients with either overproduction or overabsorption, but less commonly both. Overproducers: Significant portion of hypercholesterolemia patients, especially those with genetic conditions like Familial Hypercholesterolemia. Overabsorbers: Often have high-cholesterol diets or genetic predispositions. Treatment Implications: Overproducers: Statins are first-line treatment; they inhibit HMG-CoA reductase in cholesterol synthesis. Overabsorbers: Ezetimibe, which inhibits intestinal cholesterol absorption, can be effective. Combination Therapy: Considered for mixed dyslipidemia cases. Case Examples: Example of a patient with high production markers but borderline absorption: Statin therapy may be appropriate, with potential addition of Ezetimibe. Example of a patient who is a high absorber but not a high producer: Dietary changes and Ezetimibe might suffice without statins. Section 4: Physiological Mechanisms and Genetic Considerations Pathophysiology of Cholesterol Production: Overproduction may result from genetic mutations (LDL receptor or PCSK9) or conditions like insulin resistance. Pathophysiology of Cholesterol Absorption: Increased absorption could be due to genetic polymorphisms (NPC1L1 gene), leading to higher dietary cholesterol absorption. Section 5: Practical Application in Clinical Practice Incorporating the Test into Clinical Workflow: Integrate the Boston Heart Cholesterol Balance Test for patients with unexplained hypercholesterolemia or non-responders to standard therapy. Tailor treatment based on whether a patient is an overproducer, an over absorber, or both. Patient Communication: Explain test results in an understandable way, emphasizing personalized treatment plans.

Buck shares his experience visiting a cardiologist and discusses his family history of heart disease. He explains the importance of coronary calcium CT scans and the significance of calcium scores. Buck also highlights the role of lipoprotein little a (Lp(a)) in cardiovascular disease and the potential for new medications to target and lower Lp(a) levels. He explores the use of low-dose colchicine as an anti-inflammatory treatment for coronary artery disease and atrial fibrillation. 01:23 Understanding Coronary Calcium CT and Early Interventions 02:48 Advanced Cardiovascular Testing and Treatments 06:01 The Role of Lipoprotein Little A in Heart Disease 13:42 Inflammation and Coronary Artery Disease

This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their association with atherosclerosis. Buck also discusses the significance of apolipoprotein B (APO-B) in measuring the risk of cardiovascular disease. He explains how APO-B can penetrate the blood vessel wall and trigger an immune response, leading to the formation of plaque and potential heart attacks. Buck recommends keeping APO-B levels below 60 milligrams per deciliter to reduce the risk of atherosclerosis. He also mentions the importance of testing for lipoprotein little A (Lp(a)) levels, as high levels of Lp(a) are a major risk factor for atherosclerotic cardiovascular disease.

Buck explains the difference between intermittent fasting and prolonged fasting, highlighting the benefits and potential pitfalls of each.

Buck interviews Dr. Ken Frumkin on his own journey of aging and cognitive decline.

In this episode, Buck discusses gene editing and its potential implications for human health and longevity. He explains the basics of gene editing, including the structure of DNA and how genes are transcribed into proteins, then dives into the history and development of gene editing techniques, focusing on the game-changing CRISPR-Cas9 technology. He also explores the practical applications of gene editing, such as its use in treating sickle cell anemia and other genetic diseases, as well as the potential for human longevity, including targeting genes associated with aging and reversing epigenetic age.

Topics include: 00:25 Protein Intake for Longevity 12:40 Tips to Improve Sleep Quality 22:52 Is Robert F. Kennedy Jr. Controlled by a Worm

Topics include: 00:40 Is Weightloss Simply Calories In and Out? 07:10 Stem Cell Injections for NBA Players? 14:60 Statins for Lowering Cholesterol 23:19 The Impact of Nature and Nurture on Longevity

Buck Joffrey, MD discusses the concept of resilience with Stephen Sideroff, PhD. Topics include bouncing forward from stress and practical techniques to restore balance, nurture growth, and slow down the aging process. 01:35 Defining Resilience and the Ability to Adapt 08:21 Physical Balance and Mastery: Restoring Balance in the Nervous System 15:26 Self-Relationship: How It Changes Your Physiology 21:47 Resilience and Longevity 23:16 Emotion Balance and Mastery

I've been hearing about stem cells for decades. When I was a medical student going into neurosurgery, I seriously considered focusing my research on neuroregeneration with stem cells. As it turns out, few advancements were made in that arena for many years until Hans Keirstead and his team did some groundbreaking work on quadriplegics. Now Hans is focused on longevity. Hans may have found a new type of treatment for what I call inflammaging. His company, Immunis, isolates various proteins and growth factors from pluripotent stem cells that can then be used to treat pretty much all types of inflammatory-related disease (which is just about everything). I encourage you to listen to the show because there is so much snake oil in the field of stem cells that it's good to get a grasp on fact vs fiction. Timestamps: 02:00 Stem Cells 101 08:18 The Mechanism Behind 16:47 Stem Cells For Cancer 29:22 How Do Stem Cells Make You Live Longer? 46:25 FDA Indications 50:30 The Price

Buck discusses the concept of longevity clinics with the CEO of Humanaut. Show Notes: 03:53 What Does Humanaut Do? 06:07 The Team Behind Humanaut 14:49 How Does the Program Work?

Buck Joffrey, MD reviews the literature on the topic of human attraction. Topics include the brain, perception of beauty, specific aspects of beauty, and sexual dimorphism. Also included is a discussion on the role of human pheromones and attraction. Show Notes: 01:20 Facial Attraction & Cues 08:30 Facial Symmetry 11:12 The Averageness of Facial Features 13:59 Clear and Unblemished Skin 15:44 Sexual Dimorphic Traits 22:23 Smell and Pheromone

Buck has a conversation with fellow physician, Dr. Matt Brill, on the topic of intermittent fasting. They bring up the American Heart Association study as well as associated studies of breakfast skippers to reconsider the issue of eight-hour time-restricted feeding. Also discussed are the topics of ideal, protein, intake, and full-body MRI. Show Notes: 01:33 8 Hours Or Less Fasting Window = Higher Chance of Cardiovascular Disease? 04:58 Why the Study that Claimed the Correlation Was Wonky 08:02 Why There May Be Some Truth in the Studies 14:03 What to Do With Mixed Data and Opinions? 15:49 The Best Protein Intake? 22:32 Why Full Body MRI?

Buck Joffrey, MD discusses the basics of the keto diet with Amy Berger, a certified nutrition specialist. Topics include the definition of the diet, its health benefits and its role in the treatment of various disease processes including type 2 diabetes and Alzheimer's Disease. Show Notes: 03:08 Why the Keto Diet? 04:15 How Does the Keto Diet Help You Lose Weight? 05:51 Other Benefits of the Keto Diet 09:14 How Does High Blood Sugar Result in Insulin Resistance? 11:44 What Defines a Keto Diet 16:13 Lifestyle VS Intervention 19:02 The Concern with High Cholesterol with the Keto Diet 24:11 Treating Alzheimer's with the Keto Diet

Buck Joffrey, MD reviews what is known about sexually transmitted cancers. Discussion includes HIV and Hepatitis but focuses on Human Papilloma Virus which Buck believes is grossly underappreciated by people and by physicians. 01:18 HIV 05:26 Hepatitis 09:20 HPV

Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.

Buck Joffrey, MD, takes questions from the audience. Topics include human growth hormones, the potentially harmful effects of an MN, 40 Hz therapy, and visceral fat. Show Notes: 00:47 Is It Fine That I Sleep Too Much? 08:08 The 40hz Gamma Frequency and How It Relates to Brain Health 13:28 The Anti-Aging Effects of Human Growth Hormone 20:31 Reconsideration of How to Fast 29:22 Potentially Harmful Effect of NMN 33:08 Visceral vs Subcutaneous Fat

Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet. Show Notes: 01:10 Types of Fasting 03:31 Why Fasting is Beneficial From a Cellular Level 07:00 Intermittent Fasting VS Fast Mimicking Diet 14:05 How Does Fasting Help Cancer Patients 20:37 What Is in the Fast Mimicking Diet 33:38 Pills and Supplements for Fasting Mimicking Diet 41:23 Time-Restricted Feeding Based on Circadian Rhythm

Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people's health. Show Notes: 01:35 Dr. Lufkin's Personal Journey to Question the Medicine Establishment 04:14 When Did People Start to Take Metabolic Syndrome Seriously? 08:33 What Exactly is Metabolic Syndrome from a Physiological Standpoint? 10:21 The Balance Between Building and Breaking Down in the Metabolic System 14:41 Time-Restricted Feeding and Ketogenic Diet 28:31 The Role of Medications and Supplements 30:51 Lifestyle and Exercise as Intervention

Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment. Show Notes: 00:58 What Really is Healthspan? 05:06 Biological Age VS Chronological Age 07:41 The Factors that Determine Biological Aging 12:08 What Happens When You Artificially Suppress These Factors 16:58 What is Phenomics and how can it predict diseases? 24:21 How Can You Do Self Tests?

In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.

In this episode of Sapio, Dr. Buck Joffrey, MD addresses the recent American Heart Association study correlating intermittent fasting/time restricted, feeding to higher rates of cardiovascular death. Buck breaks down what we already know about the data behind intermittent fasting in both animals and in humans and tries to put the most recent study into context. He provides feedback on the study itself, including some suggestions on how to use this new information. Show Notes: 02:01 Intermittent fasting vs caloric restriction 06:57 Why Intermittent Fasting Improves Metabolic Health 10:19 Intermittent fasting while maintaining a healthy diet 12:32 The study 19:35 What does this study mean to Buck?

Buck Joffrey, MD talks to Romie Mushtaq, MD regarding stress, cortisol levels and prevention strategies including meditation and anti-inflammatory diets. Show Notes: 02:14 The definition of stress 13:16 Why does stress disrupt circadian rhythms and sleep 16:08 How do we treat stress? 21:23 Nootropics 24:39 Vagal nerve stimulator 28:34 Digital detox and meditation 33:02 Diet for stress

Buck Joffrey MD speaks to Justin Houman MD who is a urologist regarding the idea of aggressive testosterone treatment to decrease the risk of metabolic syndrome and therefore multiple other disease processes that are downstream. Other topics disgust include erectile dysfunction, early treatment with ED meds and the correlation with Alzheimer's disease. Show Notes: 1:27 Is it true that the testosterone in men in general has gone down? 02:43 Common symptoms of low testosterone 05:15 Normal level of testosterone 07:19 Testosterone and metabolic syndrome 12:49 Testosterone replacement therapy and cancer 16:03 Downside of testosterone replacement therapy 19:18 Different options to supplement testosterone 29:03 What's on the horizon? 32:50 ED and cardiovascular diseases 38:35 Should all 40+ men be on daily Cialis? 40:43 Penile pump

Buck Joffrey, MD and Linda Tyler, PhD discuss the topic of plant-based only/Vegan diets. The conversation includes topics on inflammation and nutritional concerns. Show Notes: 2:55 A plant-based diet for better health? 11:53 Balancing nutritions for the plant-based diet 20:39 Accessibility of the plant-based diet 22:30 Processed plant-based food