Longevity Roadmap

Buck Joffrey, MD interviews Anoop Kumar, MD on his perspective on health and wellness. Dr. Kumar is an emergency medicine doctor who is also knowledgeable about traditional Indian Philosophy and medicine. Show Notes: 00:43 Near-Death Experience and Shift in Perspective 07:04 The Three Minds Framework 23:03 Reevaluating the Model of Human Anatomy 27:20 The Four Engines: Nutrition, Movement, Connection, and Rest 39:24 The Four Engines of Health and Healing 41:01 Harnessing the Placebo Effect and Self-Healing

In this episode, Buck addresses questions from listeners. Topics include: 00:34 What is a healthy range in your weight? 04:28 The dangerous kind of fat 07:53 Male hormone replacement and cancer 13:12 How long does it take for the circadian rhythm to adjust to a new time zone? 18:35 The risk of cell phones?

Buck Joffrey, MD interviews Dr. Daniel Bowling from Stanford University on the science behind music and mental health. Bowling discusses the fundamentals of musicality and the research that has been done in this relatively new field of music as treatment for health-related issues. Show Notes: 02:59 What is musicality? 04:47 What is tonality? 07:05 How does music affect the brain? 11:20 Music as treatment for mental health 22:22 Does music sharpen our intellect? 27:05 Musical vs pharmaceutical interventions 30:38 How to get started on music therapy

Buck Joffrey, MD welcomes pharmacist and glutathione expert Dr. Nayan Patel. This podcast discusses the role of glutathione as an antioxidant including why it is known as the "master" antioxidant. The discussion reviews the physiology of glutathione in the body focussing on disease prevention and also discusses different mechanisms of supplementation. Show Notes: 00:48 What is oxidative stress? 04:12 What is an antioxidant and how does it work? 10:24 Glutathione and its relationship to longevity 29:12 Dr. Patel's Auro Wellness

Buck welcomes Tina Sindher, a specialist in food allergy from Stanford University Medical Center to discuss the basics of food allergy. Topics include root causes of food allergy, prevention, diagnosis, and treatment. Show Notes: 04:33 Does where you live affect your allergies? 06:46 How do you know you have an allergy and not something else? 09:40 Life-threatening allergies explained 13:41 Does allergy develop from childhood? 16:28 What makes some foods trigger allergies? 20:22 Rising gluten sensitivity 23:03 Are restrictive food policies increasing cases of allergies 26:20 The relationship between eczema and allergy 29:00 Microbiome 32:43 Desensitizing allergies

Buck Joffrey, M.D. discusses metabolic syndrome which affects 1/4 of the global adult population and how it underlies the development of virtually every other major cause of death. Show Notes: 00:13 Understanding Metabolic Syndrome 05:29 Criterias of Metabolic Syndrome 23:40: Insulin Resistance and Hyperinsulinemia 24:49: Metabolic Syndrome and Diabetes 37:49: Recommended Lab Tests 42:05: The Health Implications of Liposuction 50:42: The Importance of HSCRP

Buck talks about the common cold. He discusses the etiology, the role of cold weather, prevention and treatment of this common and frustrating problem.

Buck interviews Dr. Corey Frucht, MD, PhD, a board-certified dermatologist on the topic of aging skin and skin cancer. This episode explores the causes of aging skin and skin cancer, as well as what we can do to combat the inevitable effects of skin aging. Show Notes: 00:00:50:12 How and why can skin look young or old? 00:03:51:20 Why does the skin of people of color age slower? 00:05:14:09 How exactly does UV light damage your skin? 00:07:05:01 Sunscreen 101 00:11:41:08 Physical blockers vs chemical blockers 00:13:41:00 Can you get tan without damaging your skin? 00:14:16:06 How to keep your skin young 00:29:24:14 Skin Cancer

In this special New Year episode, Buck reviews some of the concepts discussed on the show in 2023.

In this episode, Buck addresses questions from listeners. Topics include oral hygiene, Alzheimer's disease, and Matthew Perry's ketamine-related death.

Buck talks about mindset and the self-inflicted limits of the "survivor."

Buck Joffrey, MD summarizes his literature search on what the data says in regards to the mechanisms by which the most common diseases of age such as cardiovascular disease and cancer might be correlated with chronic inflammation. There is also a discussion around the role of therapeutics and supplements as it relates to treating chronic inflammation and aging related disease.

In this brief video, Buck Joffrey discusses literature suggesting that there is a "Goldilocks" zone for exercising for longevity. He also talks about the research on ultramarathoners suggesting that the once an upper limit of exercise is exceeded, risks to health potentially outweigh the benefits.

Buck reviews the physiology behind human growth, hormone in humans. He discusses normal growth hormone patterns as people age, pathologies and studies of people with both growth, hormone deficiencies and excess. Buck also discusses the risks and benefits of human growth hormone supplementation in otherwise normal middle-aged adults.

Stress is an unavoidable element in modern society. Inherently, We know it's bad for us. In this episode of Sapio, Buck looks at the scientific and medical literature to drill down on the real health implications of health and offers some proven stress relief strategies. 00:00:27:24 What happens in your body when you get stressed? 00:06:26:03 How to decrease your level of stress?

In this episode of Sapio with Buck Joffrey, Buck welcomes back Dr. Alan Viglione of Montecito Concierge Medicine. Dr. Viglone discuss several topics based on audience questions including: 00:03:01:15 Is moderate alcohol intake good or bad for you? 00:09:08:02 Pills for alcohol cravings 00:15:40:20 Is the carnivore diet healthy? 00:22:20:22 Optimal exercise for endurance runners 00:30:43:04 Where and why you should get genetic testing done to prevent disease? 00:36:46:13 Can you do anything about your gene that makes you prone to Alzheimer's diease? 00:40:24:09 Is human growth hormone or sermorelin bad for you?

In this episode of Sapio with Buck Joffrey, Buck discusses the importance of setting clear goals and truly believing they can be achieved. He emphasizes the need to honestly evaluate if one's current plans will achieve their goals, and make adjustments if needed.

In this episode of Sapio with Buck Joffrey, Buck reveals the supplements and drugs that he takes for the purpose of longevity. In addition to providing specific drugs and supplements, he talks about the reasoning for each and the big picture around how he looks at longevity regimens. Show Notes: 00:03:38:01 A legit source of information for supplements 00:04:17:24 Supplements for cardiovascular diseases 00:10:10:19 Supplements for all organs 00:14:21:07 Supplements for longevity

Buck provides ways to prevent getting deep venous thrombosis during long flights and drives. Deep Venous thrombosis refers to clots in the deep veins of the legs that can break free and cause a life threatening emergency called pulmonary embolism which represents blood clots in the arteries of the lungs.

In this episode of Sapio, Buck drills down on the importance of adequate levels of protein in a diet designed for longevity. Buck talks about the concept of Sarcopenia and the relationship between inadequate protein and chronic disease processes. He also talks about sources of protein, including the difference between animal and plant protein sources. He concludes with some recommendations based on individual needs when considering how much protein, and what source of protein to use including supplementation strategies. Show Notes: 00:01:03:21 Proteins: what is it and what's the big deal? 00:03:02:04 Where do we get amino acids? 00:03:49:04 Protein, sarcopenia, and mortality 00:06:45:07 How much protein should you eat? 00:09:15:20 Why the carnivore diet may not be the best for longevity 00:12:06:09 Does it matter if your protein supplements are animal or plant based?

In our last episode of Sapio with Buck Joffrey, Neurologist Dr. John Foley took us through the diagnosis and pathophysiology behind Alzheimer's disease He also told us about the risk factors for getting Alzheimer's disease—both avoidable and not. In this episode, we talk about what we can do to mitigate the risk of developing Alzheimer's disease, even if you are genetically predisposed to it. We talk about everything from Saunas to supplements. We also take a look at the cutting-edge research and new therapies that might actually be able to treat Alzheimer's disease that may be right around the corner. Again, this is a must listen for anyone who wants to live a long healthy life with all of their cognitive abilities and memories intact. It is relevant to you and probably to someone in your family and I'm hopeful that by listening to this show, you will be able to come away with actionable information for you or your loved ones to play offense against this brutal disease. By the way, if you want to see what Dr. Foley is up to with his neuro-optimization clinic, make sure to check out his website for cerepro bioscience at cereprobio.com

In the next two episodes of Sapio with Buck Joffrey, we are going to talk about Alzheimer's disease. If you have never seen someone progress through the different stages of Alzheimer's disease, consider yourself lucky. This is a heartless disease that robs people of their most prized possession: their memories of their loved ones and of everything else about their lives. It also robs them of their ability to function in this world. Over the next 2 episodes of Sapio, you are going to learn what Alzheimer's disease is, what the risk factors are, the steps we can take to minimize our risk of getting Alzheimer's disease in the future, and even potential cures on the horizon. My expert guest for these discussions is my friend Dr. John Foley. Dr. Foley is a neurologist who is at the cutting edge of the clinical and scientific advances in the treatment of Alzheimer's disease and MS. Make sure to tune in to this show. I guarantee you that it's relevant to you or to someone you love. Show Notes: 00:02:49:20 What is dementia? 00:03:49:21 How to Make a Diagnosis of Alzheimer's Disease 00:05:46:19 The Story of Alois Alzheimer 00:07:22:06 What is Alzheimer's 00:10:22:14 Why do people get Alzheimer's? 00:13:05:15 The Risk Factors 00:23:14:09 What is sleep fragmentation and how does an understanding of it help with Alzheimer's? 00:29:25:03 The Genetics of Alzheimer's 00:35:41:20 How do hearing loss and hearing aid relate to Alzheimer's? Learn more about Dr. John Foley at cereprobio.com

Buck discusses his new book, Living Longer for Busy People in a question/answer session with producer, Ben Hyatt.

Sapio with Buck Joffrey Episode 47 is part 2 of a 2 part episode with Dr. Tom Walters, DPT, OCS. Tom is a Doctor of Physical Therapy, former Kinesiology Professor, author of the bestselling book "Rehab Science: How to Overcome Pain and Heal From Injury". He is also an Instagram and YouTube creator with with more than 1.6 million combined followers, with a focus on "Alleviating Pain and Moving Better". In part 2 of this 2 part episode Tom and Buck discuss supplements, sleep, pain and the things you should be doing to help you live longer and stay healthier. Make sure to check out episode 46 as well to get the whole conversation. Tom can be found on Instagram (@rehabscience) and YouTube. His book is available on Amazon, Barnes & Noble and Target. Find links to other resources including a free Injury Prevention Program at https://rehabscience.com/links/.

Sapio with Buck Joffrey Episode 46 is part 1 of a 2 part episode with Dr. Tom Walters, DPT, OCS. Tom is a Doctor of Physical Therapy, former Kinesiology Professor, author of the bestselling book "Rehab Science: How to Overcome Pain and Heal From Injury". He is also an Instagram and YouTube creator with with more than 1.6 million combined followers, with a focus on "Alleviating Pain and Moving Better". In part 1 of this 2 part episode Tom and Buck discuss excercise and the things you should be doing to help you live longer and stay healthier. Also discussed in detail is pain. These are both very important topics for overall quality of life and longevity. The things you do today will impact your overall well being for decades to come. Don't miss part 2 (episode 47) which drops Wednesday. Tom can be found on Instagram (@rehabscience) and YouTube. His book is available on Amazon, Barnes & Noble and Target. Find links to other resources including a free Injury Prevention Program at https://rehabscience.com/links/.

It's not just how much you sleep but WHEN you sleep that can affect your chances of getting Alzheimer's Disease. Buck Explains.

In Episode 44 of Sapio with Buck Joffrey, Buck discusses research that shows this old drug can be repurposed to fight the number one killer.

In this Medical Update, Buck talks about one quick thing you can do to significantly improve the quality of your sleep. It goes against what we've been told but everyone should do it. The data backs it!

In our latest "Ask The Doctor" episode, Dr. Alan Viglione joins Buck for a conversation that includes how to find a doctor that's right for you, the placebo effect and suplements.

In this medical update Buck discusses news from the FDA about some of the most popular drugs at your pharmacy. Buck also discusses some alternatives to the medication.

In this Sapio with Buck Joffrey episode Buck talks to Dr. Sean London from Prenuvo. A company revolutionizing healthcare with it's full body MRI scans. This is all about Medicine 3.0. Early detection is key in fighting many diseases including cancer for example. Buck recently had the procedure and Dr. London goes through some of the findings - one of which was a bit of a surprise.

🎧 Dive deep into the world of weight loss solutions in this eye-opening episode of Sapio with Buck Joffrey. As the buzz around Wegovy and Ozempic intensifies, we dissect the promises and pitfalls. Can it truly tip the scales in favor of those battling the bulge? Join us for an exploration of this groundbreaking treatment. 👍 Like, share, and weigh in: Would you consider Wegovy as a weight loss solution? #SapioPodcast #BuckJoffreyInsights #WegovyExplained #TippingTheScales #WeightLossInnovation #BeyondTheBuzz #HealthTrends #ModernMedicine #WeightLossJourney #DiabetesToDiet #Wegovy #Ozempic #semaglutide

In this Sapio with Buck Joffrey Episode Short, Buck discusses Biological Age and how it is different than Chronological Age. Which of the two should be the true measure of a person's age?

In this Sapio with Buck Joffrey Medical Update, Buck discusses depression and the psychedelics being used to treat it including Psilocybin and Ketamine. Depression can have a series negative impact on longevity and impacts millions of people.

🎧 New Episode of Sapio with Buck Joffrey: The world is buzzing about the benefits of cold therapy, but is it all it's cracked up to be? 🧊 Buck delves deep into the icy waters of this wellness trend, separating fact from fiction and exploring whether the chills are worth the hype. Tune in for an eye-opening discussion and decide for yourself! 👍 Like, share, and let us know your thoughts on cold therapy! #SapioPodcast #BuckJoffreyInsights #ColdTherapyTruths #WellnessDebunked #HealthySkepticism #WellnessTrends #FactOrFiction #HealthMyths

In this Sapio with Buck Joffrey Medical Update, Buck discusses new reasearch that connects hearing loss and dementia. If you or a loved one is suffering from hearing loss you are going to want to take action.

In this episode of Sapio with Buck Joffrey Dr. Duncan Turner joins Buck for a conversation on women's health, sexual dysfunction and what can be done about it.

The exploration into the secrets of aging continues in this much-anticipated second part of our conversation with Dr. Joel Rothman from UCSB's Center for Aging and Longevity Studies (CALS). Join Buck as they dive further into the fascinating breakthroughs that are setting the stage for a potential revolution in human longevity. Tune in to episode 33 for a straightforward, yet enlightening discussion on the future of aging. 00:00:53 - Understanding Mitochondria 00:04:32 - Mitochondria and Aging 00:04:56 - Mitochondrial DNA 00:09:15 - Mitochondrial Dysfunction 0:09:48 - Removing Damaged Mitochondria 0:13:54 - Mitochondrial DNA and Aging 0:15:57 - Epigenetics and Aging 0:17:36 - Exploring Other Mechanisms Related To Longevity 0:19:08 - Understanding Stress Response 0:19:25 - Types of Stress 0:20:32 - Stress Response Systems in Cells 0:21:08 - Manipulating Stress Response 0:21:54 - Artificially Activating Stress Response 000:22:38 - Stress Response and Aging 00:23:43 - Hormesis and Longevity 00:24:32 - Heat and Cold Stress 00:25:29 - Interplay of Different Factors 00:26:07 - Studying Aging in Worms 00:26:28 - Debate on Aging Research 00:32:36 - Ethical Implications of Longevity Research 00:34:14 - Addressing Ethical Concerns 00:35:40 - Potential Issues with Extended Lifespan 00:38:18 - Longevity and Population Growth 00:39:28 - Ethical Considerations of Extending Lifespan 00:40:42 - Impact on Population Growth 00:42:02 - Predictions for Future Access to Technology

In this can't-miss episode, Buck engages in a riveting conversation with the Dr. Joel Rothman, the Founding Director at UCSB's Center for Aging and Longevity Studies (CALS). Prepare to be transported into the cutting-edge world of scientific discoveries that are reshaping our understanding of aging, potentially unlocking the secrets to unprecedented human longevity. This is only the beginning! Be sure to catch the continuation of this talk in episode 33, where we delve even deeper into the groundbreaking breakthroughs at the frontier of aging research including the research being done at CALS. 00:02:24 - The Science of Aging: A Deeper Dive 00:04:34 - The Human Lifespan 00:07:04 - The Different Lifespans of Organisms 00:09:12 - Aubrey de Grey Longevity Escape Velocity 00:12:27 - The Brain and Aging 00:13:47 - David Sinclair's Book Lifespan 00:14:23 - The Role of Epigenome in Aging 00:19:10 - Genes and Epigenome 00:20:41 - DNA Methylation and Chromosome Structure 00:22:02 - Information Theory of Aging 00:24:14 - Proteostasis or removal of defective proteins 00:26:17 - The Horvath Clock and Biological Clocks 00:30:50 - Epigenome Reset 00:33:53 - Yamanaka Factors 00:37:00 - Extending Healthspan through Cocktails 00:41:44 - Challenges in Drug Development

Episode 31 of Sapio with Buck Joffrey discusses "What Covid does to your Brain". In this short episode Buck discusses his personal experience and the after affects which lasted several weeks after testing negative. 00:00:12 - Buck's experience with the original COVID strain 00:01:12 - COVID and Depression 00:01:57 - Damage to the Ventral Striatum and Anhedonia 00:02:19 - COVID possibly affecting the Posterior Putamen which is involved with speech, articulation and other cognitive functioning

In this episode of Sapio with Buck Joffrey, Buck discusses a new study out of Oxford that outlines 11 key risk factors for dementia. And the good news - while you can't change everything, many of these factors can be controlled buy modifying behaviors. If your want to see more info on the study goto: https://www.psych.ox.ac.uk/news/new-dementia-risk-score-helps-identify-people-at-risk. 00:00:02 - The difference between Alzheimer's Disease and Dementia 00:01:02 - Diagnosing Alzheimer's disease 00:01:25 - Causes of Dementia 00:01:48 - Dementia risk factors and how to avoid them 00:03:08 - Parental Dementia 00:03:27 - APOE e4 as a risk factor for Alzheimer's 00:04:44 - Dementia risk factors you can control

In part 2 of this 2 part episode Buck discusses male sexual health with Justin Houman, MD from Tower Urology in Los Angeles. Over half of American men over the age of 40 suffer from erectile dysfunction and other sexual disorders. 00:00:42 - Male Refractory Period 00:01:44 - Erections are going to be weaker as you age 00:02:15 - Medication like Phosphodiesterase that help lower one's refractory period 00:02:50 - Hormone called Prolactin that can cause increased refractory time 00:07:36 - Dealing with Premature Ejaculation 00:10:24 - Paxil and Tramadol For Premature Ejaculation 00:12:10 - Prostate issues 00:12:37 - Benefits of Cialis and Flomax 00:14:49 - Testosterone Replacement 00:16:17 - Clomid for Hypogonadism and Low Testosterone 00:18:31 - Human Chorionic Gonadotropin (hCG) 00:24:08 - Preserving Fertility 00:26:39 - Testosterone Blood Testing 00:27:44 - Masturbation Effects on Testosterone Levels 00:30:30 - Supplements like Tongkat Ali and Fadogia Agrestis

In this two part episode Buck discusses male sexual health with Justin Houman, MD from Tower Urology in Los Angeles. Over half of American men over the age of 40 suffer from erectile dysfunction and other sexual disorders. Buck asks the questions many men are uncomfortable asking. 00:01:44 - The concept of Erectile Dysfunction 00:06:22 - Diagnosing Erectile Dysfunction 00:09:33 - What is sex therapy? 00:10:56 - Main causes of Erectile Dysfunction 00:12:02 - Testosterone Levels 00:15:48 - Venous Leak 00:17:32 - Erectile Dysfunction Treatment 00:20:54 - PDE5 inhibitors 00:26:14 - Erectile Dysfunction and Cardiovascular Disease? 00:31:38 - Intracavernosal injections 00:37:13 - GAINSWave Procedure 00:42:53 - Platelet-Rich Plasma (PRP) Injection

Buck discusses Yamanaka Factors and recent experiments where a team led by David Sinclair was successful in reversing cellular age applying the concepts in an experiment. 00:00:02 - Is it possible to stop or even reverse the aging process? 00:01:48 - 2012 research by Shinya Yamanaka - Yamanaka Factors 00:02:50 - Pluripotent stem cells 00:03:08 - Revolutionary discovery for the world of regenerative medicine 00:03:28 - Salk Institute study using mice with progeria 00:03:55 - Doxycycline and improvements in signs of aging 00:04:26 - David Sinclair's research to regenerate optic nerves in mice to restore vision 00:04:49 - David Sinclair's book on aging research called Lifespan 00:05:20 - Epigenome and the aging process 00:06:15 - Horvath lab and using Yamanaka factors to reset epigenetic clocks in rats

In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. This is Part 2. Listen to episode 24 to hear part 1. 00:01:31 - Question about taking naps to make up for not enough sleep 00:03:06 - REM Sleep and Deep Non-REM Sleep 00:11:54 - Shift work is very detrimental to to health 00:13:11 - Question about reversing aging in cells 00:13:29 - David Sinclair's book Lifespan 00:15:30 - Stem cells and aging 00:17:22 - Genetically mutated rodents with Progeria and the Yamanaka Factor 00:21:59 - Methylation and the Epigenome 00:22:37 - Biological clocks and changes in the Epigenome 00:23:20 - Sinclair's study on using a drug cocktail to reverse the cellular aging patterns in aged human cells

Buck discusses Heart Rate Variability (HRV). What is it? Why does it matter and how can it effect your overall health in this mini Sapio with Buck Joffrey episode. 00:00:31 - Medicine 3.0: Taking medicine into your own hands 00:01:15 - What is Heart Rate Variability (HRV) anyway? 00:02:16 - The Autonomic Nervous System 00:02:37 - The Parasympathetic Nervous System 00:03:32 - Lower Hrv Has Been Linked To An Increased Risk Of Cardiovascular Diseases 00:04:18 - Ways To Increase Your HRV

In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. Part 2 will drop next week as episode 26. 0:01:11 - Question about Continuous Glucose Monitoring and Repatha® 0:04:34 - Where is the glucose coming from in the morning? 0:07:07 - Blood Glucose Spike in the sauna 0:09:43 - Impact on blood sugar of the order of eating food 0:12:18 - Continuous Glucose Monitor App 0:13:29 - A question about avoiding jet lag 0:13:26 - Minimizing Jet Lag and Melatonin 0:16:15 - Adjust your watch to the timezone you are going to be at 0:19:29 - Getting your brain acclimated to the new time 0:22:30 - Warning about taking Melatonin 0:26:59 - A question about Vibration Plates and their benefits 0:27:23 - Vibration Plates and the claim of increasing Growth Hormones 0:32:39 - Back Pain and Vibrating Plates 0:33:47 - What happened to Bronny James? 0:34:27 - Hypertrophic Cardiomyopathy 0:40:54 - Athletes and Heart Disorders

Planning a trip? Jet lag can be a serious impediment to making the most of it. Buck discusses jet lag; what it is and strategies to beat it including the use of Melatonin. 00:00:25 - Desynchronosis - Disruption To Your Circadian Rhythm 00:01:05 - Melatonin 00:02:39 - Bright Light Exposure Is Really Important To Resetting Your Circadian Clock 00:04:48 - Some Negative Effects Of Chronic Melatonin Use

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. This is Part 2. If you missed Part 1, check out episode 20. 0:01:16 - Metabolic Markers and Cardiovascular Risk 0:01:55 - Framingham Risk 0:06:08 - Hemoglobin A1C 0:08:00 - C-peptide 0:09:07 - Homocysteine and the methylation cycle 0:11:50 - Methyl Protect® 0:13:46 - Why is Vitamin D important? 0:21:34 - APOE Genotype 0:24:35 - Alzheimer's Disease Risk 0:28:57 - Colchicine Study