Neurology® Podcast

Dr. Tesha Monteith talks with Dr. Cecilia Hvitfeldt Fuglsang about the effects of migraine and PIH on the risk of stroke and myocardial infarction. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Deanna Saylor talks with Prof. Mayowa Owolabi about reducing the global burden of stroke. Read the related article in Lancet Neurology.

Dr. Halley Alexander talks with Dr. Genna Waldman about her presentation at the AES (Annual Epilepsy Society) symposium session reviewing PNEE (psychogenic non-epileptic events) and indications of discontinuation of medications. Articles referenced in the episode: https://doi.org/10.1111/epi.12356 https://www.sciencedirect.com/science/article/pii/S1059131119300342 https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.2567 https://doi.org/10.1111/j.1528-1167.2010.02696.x https://doi.org/10.1016/j.yebeh.2021.108004 Disclosures can be found at Neurology.org.

Dr. Stacey Clardy talks with Dr. Geoff Ling about his thoughts on rapid-fire mortar shooting and more broadly, how he goes about identifying what veterans have been exposed to and treating veterans in the clinic. They also discussed a little bit about a recently published article in the New York Times titled, "A Secret War, Strange New Wounds, and Silence from the Pentagon." Disclosures can be found at Neurology.org.

Dr. Jason Crowell talks with Dr. Elsmarieke van de Giessen and Emma Coomans about a newly FDA-approved tau-binding radiotracer [18F]flortaucipir and an accompanying visual read method to support the diagnostic process in cognitively impaired patients assessed for Alzheimer disease. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Gordon Smith talks with Prof. Mike Lunn about the relationship between COVID-19 vaccinations and Guillain-Barré syndrome using the National Immunoglobulin Database. Read the related article in Brain. Disclosures can be found at Neurology.org.

Dr. Derek Stitt talks with Dr. Ali A. Habib about trends in hospital admissions and in-hospital mortality for adult patients with MG. Read the related article in Neurology®. Disclosures can be found at Neurology.org.

Dr. Jason Crowell talks with Dr. Benjamin N. Rome about ways to improve pharmacy benefit managers and the way they function in the system. Read the related article in The New England Journal of Medicine. Referenced in this Episode: June 2021 Neurology Recall Episode Disclosures can be found at Neurology.org.

Dr. Gordon Smith talks with Dr. Haya Bishara about the association between GBS and both SARS-CoV-2 infection and the COVID-19 vaccine. Read the related article in Neurology. Disclosures can be found at Neurology.org.

The January 2024 replay starts the new year off with four previously posted episodes on dementia. The episode begins with an interview with Dr. Kenneth Langa on the prevalence of dementia and mild cognitive impairment in the US. The episode continues with an interview with Dr. Beau Ances about the burden amyloid has on individuals with Down syndrome compared to autosomal dominant Alzheimer disease. The next interview is with Dr. Erik Musiek on the use of lecanemab in early Alzheimer disease. The fourth and final interview is with Dr. Vijay Ramanan on the eligibility for anti-amyloid treatment. Related Podcast Links: Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the United States: https://directory.libsyn.com/episode/index/id/25811241 Comparison of Amyloid Burden in Individuals with Down Syndrome Versus Autosomal Dominant Alzheimer Disease: https://directory.libsyn.com/episode/index/id/25881414 Lecanemab in Early Alzheimer Disease: https://directory.libsyn.com/episode/index/id/25428333 Eligibility for Anti-Amyloid Treatment: https://directory.libsyn.com/episode/index/id/28300052 Related Article Links: Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: https://jamanetwork.com/journals/jamaneurology/article-abstract/2797274?resultClick=1 Comparison of Amyloid Burden in Individuals with Down Syndrome Versus Autosomal Dominant Alzheimer's Disease: A Cross-Sectional Study: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00408-2/fulltext Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging: https://www.neurology.org/doi/10.1212/WNL.0000000000207770 Disclosures can be found at Neurology.org

Dr. Jeff Ratliff talks with Drs. Divya Singhal and Myriam Abdennadher about work-life, parenting, and the well-being of neurologists during the COVID-19 pandemic. Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org.

Dr. Andrew Southerland talks with Dr. Franzi Herpich about her journey of experiencing a stroke in 2021 as part of our physician-as-patient series. Previously Posted Content: April 2022 Neurology Recall: Physician as Patient Disclosures can be found at Neurology.org.

Dr. Adam de Havenon talks with Dr. Gustaf Edgren about the potential transmissible risk associated with some types of spontaneous intracerebral hemorrhage in patients who receive transfusions. Read the related article in JAMA. Disclosures can be found at Neurology.org.

Dr. Elizabeth Coon talks with Dr. Mitchell G. Miglis about the frequency of orthostatic hypotension in isolated REM sleep behavior disorder. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Jeff Ratliff talks with Drs. Michael Fox and Jacob Stubbs about their study on brain network associations in substance use disorders. Read the related article in Nature. Disclosures can be found at Neurology.org.

Dr. Farrah Mateen talks with Sumaira Ahmed about The Sumaira Foundation and their global ambassador program for patient advocacy. Learn more about The Sumaira Foundation. Disclosures can be found at Neurology.org

Dr. Gordon Smith talks with Laynie Dratch about integrating genetic testing into patient care for persons with Amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) spectrum disorders. Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org

Dr. Andy Southerland talks with Dr. Jonathan Coutinho about the accuracy of using EEG in the detection of large vessel occlusion stroke in prehospital settings. Read the related article in Neurology. Disclosures can be found at Neurology.org

The December 2023 replay wraps up the year with four previously posted episodes on neurocritical care. The episode begins with an interview with Dr. Karin Diserens on subtle clinical signs in unresponsive brain-impaired individuals. The episode continues with an interview with Dr. David Greer on updated brain death guidelines. The next interview is with Dr. Monica Lemmon on communicating information about neurologic prognosis. The fourth and final interview is with Drs. Susanne Muehlschlegel and Adeline Goss on the prognostic language used in critical neurologic illness. Related Podcast Links: Subtle Clinical Signs in Unresponsive Brain Impairment: https://directory.libsyn.com/episode/index/id/27124839 Updated Pediatric and Adult BD/DNC Consensus Guidelines: https://directory.libsyn.com/episode/index/id/28537073 A Parent-Informed Approach to Communicating Neurologic Prognosis in Infants: https://directory.libsyn.com/episode/index/id/25988781 Language Use in Neurocritical Illness Prognostication: https://directory.libsyn.com/episode/index/id/28137575 Related Article Links: A Focus on Subtle Signs and Motor Behavior to Unveil Awareness in Unresponsive Brain-Impaired Patients: The Importance of Being Clinical: https://doi.org/10.1212/WNL.0000000000207067 Pediatric and Adult Brain Death/Death by Neurologic Criteria Consensus Guideline: Report of the AAN Guidelines Subcommittee, AAP, CNS, and SCCM: https://doi.org/10.1212/WNL.0000000000207740 The ALIGN Framework: A Parent-Informed Approach to Prognostic Communication for Infants With Neurologic Conditions: https://doi.org/10.1212/WNL.0000000000201600 Prognostic Language in Critical Neurologic Illness: A Multicenter Mixed-Methods Study: https://doi.org/10.1212/WNL.0000000000207462 Disclosures can be found at Neurology.org

Our 2023 November Headache series wraps up with Dr. Tesha Monteith talking with Dr. Stewart Tepper about rapid developments in neuromodulation. Disclosures can be found at Neurology.org

Dr. Tesha Monteith talks with Dr. Peter Goadsby about updates on migraine treatments and the integration of CGRP inhibitors into clinical practice. Disclosures can be found at Neurology.org

Dr. Tesha Monteith talks with Dr. Messoud Ashina about the mechanisms of migraine. Articles Referenced in this Episode: Calcitonin Gene-related Peptide Causes Migraine Aura An Exploratory Analysis of Clinical and Sociodemographic Factors in CGRP-induced Migraine Attacks: A REFORM Study Disclosures can be found at Neurology.org

Dr. Andrew Southerland talks with Dr. Seemant Chaturvedi about exciting new trials that have come out in the world of stroke that were presented at this year's World Stroke Congress. Read more on the World Stroke Congress page. Disclosures can be found at Neurology.org

Dr. Tesha Monteith talks with Drs. Deb Friedman and Kathleen Digre about the diagnosis and management of idiopathic intracranial hypertension and cerebrospinal fluid pressure disorders. Disclosures can be found at Neurology.org

Dr. Farrah Mateen talks with Dr. Teddy Totimeh about the urgent need to improve/develop existing and nonexistent neuro-oncology infrastructure, personnel, and logistics across borders. Read the related article in World Neurosurgery. Disclosures can be found at Neurology.org

Dr. Tesha Monteith talks with Dr. Stephanie Nahas about commonly missed and lesser-known primary headache disorders. Disclosures can be found at Neurology.org

Dr. Halley Alexander talks with Dr. David Greer about updating and clarifying the brain death/death by neurologic criteria guidelines for adult and pediatric patients. Read the related article in Neurology. Visit NPub.org/Podcast for associated article links. Disclosures can be found at Neurology.org

Dr. Tesha Monteith talks with Drs. Hayrunnisa Bolay, KC Brennan, and Gianluca Coppola about the International Headache Conference that took place in September and clinical advances in headache medicine. Read more about the 2023 IHC. Disclosures can be found at Neurology.org

The November 2023 replay of past episodes showcases five interviews on topics in stroke. The episode begins with an interview with Dr. Imogene Scott on prehospital telestroke vs paramedic scores to accurately identify stroke reperfusion candidates. The episode continues with an interview with Dr. David Seiffge on the use of oral anticoagulants on ischemic stroke. The next interview is with Dr. Alejandro Rabinstein and Hassan Kobeissi on comparing outcomes between CTP and NCCT for endovascular therapy selection in the late therapeutic window. The fourth interview is with Dr. Thanh Nguyen discussing whether dual antiplatelet therapy is non-inferior to intravenous thrombolysis among patients with minor non-disabling acute ischemic stroke. The November Recall concludes with Dr. Seemant Chaturvedi discussing this year's European Stroke Organization Conference and pivotal trials that were presented during the conference. Related Podcast Links: Pre-Hospital Evaluation of Acute Stroke: EMS vs Telemed: https://directory.libsyn.com/episode/index/id/24928863 Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants: https://directory.libsyn.com/episode/index/id/25736865 CT Perfusion vs CT for Late Window Stroke Thrombectomy: https://directory.libsyn.com/episode/index/id/26673237 Dual Antiplatelet Therapy vs Alteplase for Patients With Acute Ischemic Stroke: https://directory.libsyn.com/episode/index/id/27455412 Pivotal Stroke Trials Presented at this Year's ESOC: https://directory.libsyn.com/episode/index/id/27279144 Related Article Links: Prehospital Telestroke vs Paramedic Scores to Accurately Identify Stroke Reperfusion Candidates: A Cluster Randomized Controlled Trial: https://n.neurology.org/content/99/19/e2125 Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants: https://jamanetwork.com/journals/jamaneurology/fullarticle/2799622 CT Perfusion vs Noncontrast CT for Late Window Stroke Thrombectomy: A Systematic Review and Meta-analysis: https://n.neurology.org/content/100/22/e2304 Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial: https://jamanetwork.com/journals/jama/article-abstract/2806532 ESOC Plenary: https://2023.eso-conference.org/programme/plenary-highlights/ Disclosures can be found at Neurology.org

Dr. Stacey Clardy talks with Drs. Brian Stamm and Behnam Sabayan about the spectrum of clinical presentations, neuroimaging patterns, and the predictors of radiographic and clinical outcomes from diffusion-restricted splenial lesions. Read the related article in Neurology: Clinical Practice. Visit NPub.org/Podcast for associated article links. Disclosures can be found at Neurology.org

Dr. Jeff Burns talks with Dr. Natalia Rost about the AAN's brain health initiative. Read the related article in Neurology. Visit NPub.org/Podcast for associated article links.

Dr. Jennifer Majersik talks with Samantha Cote about the relationship between lifetime hormone exposure and cerebral small vessel disease in postmenopausal women in the UK-Biobank. Read the related article in Neurology. Visit NPub.org/Podcast for associated article links.

Dr. Kait Nevel talks with Dr. Philipp Karschnia about the assessment on whether MTHFR polymorphisms affects the risk for leukoencephalopathy. Read the related article in Neurology. Visit NPub.org/Podcast for associated article links.

Dr. Jeff Ratliff talks with Dr. Gregg Day about the adaption of the STAM3P screening scores in clinical practice to minimize diagnosis delays and missed opportunities for treatment in patients with suspected rapidly progressive dementia. Read the related article in Annals of Neurology. Visit NPub.org/Podcast for associated article links.

Dr. Gregg Day talks with Dr. Vijay Ramanan about the clinical trial eligibility criteria for lecanemab treatment for participants with early Alzheimer disease and the generalizability of anti-amyloid treatment. Read the related article in Neurology. Visit NPub.org/Podcast for associated article links.

Dr. Andy Southerland talks with Dr. Christine Mc Carthy about the connection between sleep disturbance symptoms and the risk of acute stroke. Read the related article in Neurology. Visit NPub.org/Podcast for associated article links.

Dr. Halley Alexander talks with Dr. Sándor Beniczky about the use of artificial intelligence to accurately interpret routine clinical electroencephalograms. Read the related article in JAMA Neurology. Visit NPub.org/Podcast for associated article links.

Dr. Alex Menze talks with Dr. Marianne Chanti-Ketterl about the association between traumatic brain injury and cognitive decline among older veteran men. Read the related article in Neurology. Visit NPUb.org/Podcast for associated article links.

The October Neurology Recall highlights Dr. Justin Abbatemarco's four-part series on autoimmune encephalitis from August 2023. The episode begins with Dr. Josep Dalmau discussing relevant updates and ongoing/upcoming research around autoimmune encephalitis. The next episode discusses the practical approach to testing for auto antibodies in autoimmune encephalitis with Drs. Drs. Sarosh Irani and John Soltys. The episode continues with Drs. Eoin Flanagan and Grace Gombolay helping expand the differential diagnosis in autoimmune encephalitis cases. The October Recall concludes with Dr. Maarten Titulaer talking about the importance of longitudinal care for patients with autoimmune encephalitis. Related Links: Autoimmune Encephalitis Series: Advancing the Science Trials in ALS - https://directory.libsyn.com/episode/index/id/27682701 Autoimmune Encephalitis Series: A Rationale Approach to Diagnostics and Interpretation - https://directory.libsyn.com/episode/index/id/27712707 Autoimmune Encephalitis Series: Expanding the Differential - https://directory.libsyn.com/episode/index/id/27747390 Autoimmune Encephalitis Series: The Importance of Longitudinal Care - https://directory.libsyn.com/episode/index/id/27901296

Dr. Andy Southerland talks with Dr. Brian Callaghan about patient travel distance and travel time to neurologist visits, across neurologic conditions and subspecialties. Read the related article in Neurology. Visit NPUb.org/Podcast for associated article links.

Dr. Neha Dangayach talks with Drs. Susanne Muehlschlegel and Adeline Goss about characterizing the prognostic language clinicians use in critical neurologic illness. Read the related article in Neurology. Visit NPUb.org/Podcast for associated article links.

Dr. Derek Stitt talks with Prof. Clemens Warnke about the clinical presentation of progressive multifocal leukoencephalopathy, its variants, pathogenesis, and current diagnostic approaches. Read the related article in Neurology. Visit NPUb.org/Podcast for associated article links.

Dr. Farrah Mateen talks with Dr. Richard Benson about the NINDS health equity efforts and the implications of the new strategic plan for research. Read the related supplement in Neurology. Visit NPUb.org/Podcast for associated article links.

In the last episode of our three-part series, Prof. Jon Stone talks with Drs. Selma Aybek, David Perez, and Sarah Lidstone about diagnosis and treatment for FND. Related Links: FND Society at fndsociety.org FND guide for patients at neurosymptoms.org FND Hope at fndhope.org Visit NPUb.org/Podcast for associated article links.

Dr. Matt Barrett talks with Drs. Julie A. Schneider and Sonal Agrawal about whether Lewy body and cerebrovascular pathologies act synergistically to increase the severity of parkinsonism beyond their separate effects. Read the related article in Neurology. Visit NPUb.org/Podcast for associated article links.

Dr. Jessica Ailani talks with Dr. Aaron Kesselheim and Leigh Sharpless about the endpoints used in trials supporting the US FDA approval of medications treating migraines. Read the related article in Neurology. This episode was sponsored by the ExTINGUISH Trial for NMDAR Encephalitis: Call 844-4BRAIN5 to refer patients.

Dr. Alexander Menze talks with Dr. Brooke Conway Kleven about the association between a clinical diagnosis of traumatic encephalopathy syndrome and subsequent temporal decline in cognitive or MRI volumetric measures. Read the related article in Neurology. Visit NPUb.org/Podcast for associated article links. This episode was sponsored by the ExTINGUISH Trial for NMDAR Encephalitis: Call 844-4BRAIN5 to refer patients.

The September 2023 Neurology Recall showcases five dynamic interviews about ALS. The episode begins with a discussion about the strategic plan for ALS from the NINDS with Dr. Walter Korshetz. This episode features conversations with Drs. Ruben P.A. van Eijk-3 and Jordi van Unnik on simulation based interim analysis of ALS clinical trials followed by an interview with Dr. Emily Plowman on respiratory strength training (RST) programs in individuals with ALS. The episode continues with an interview with Dr. Suma Babu on the approved treatment for ALS associated with a mutation in the SOD1 gene. This month's Recall concludes with a conversation with Dr. Ajay Sampat on his story of being a neurologist diagnosed with ALS. Related Articles: Development and Evaluation of a Simulation-Based Algorithm to Optimize the Planning of Interim Analyses for Clinical Trials in ALS Respiratory Strength Training in Amyotrophic Lateral Sclerosis FDA Approves Treatment of Amyotrophic Lateral Sclerosis Associated With a Mutation in the SOD1 Gene Related Podcast: The ALS Strategic Plan from NINDS Simulation-Based Planning of ALS Trials Respiratory Strength Training in ALS FDA Approved Therapy for SOD1 Associated ALS A Neurologist's Experience as a Patient with ALS Visit NPUb.org/Podcast for associated article links. Disclosures can be found at Neurology.org.

In the fourth episode of a four-part series on autoimmune encephalitis, Dr. Justin Abbatemarco talks with Dr. Maarten Titulaer about the importance of longitudinal care for autoimmune encephalitis. Visit NPUb.org/Podcast for additional podcasts and associated article links. Disclosures can be found at Neurology.org.

In the second episode of our three-part series, Prof. Jon Stone talks with Drs. Selma Aybek, David Perez, and Sarah Lidstone about how and why FND occurs. Related Links: FND Society at fndsociety.org FND guide for patients at neurosymptoms.org FND Hope at fndhope.org Visit NPUb.org/Podcast for associated article links. Disclosures can be found at Neurology.org.