Neurology® Podcast

In this episode dedicated to the memory of Neurology Podcast Founder Dr. Ted Burns, Dr. Jeff Ratliff narrates a compilation of excerpts from a previously recorded discussion between Dr. Stacey Clardy and Ted Burns in 2021 about Ted's journey with the podcast and his impact on neurology education.

The July 2022 replay of past episodes showcases a selection of interviews that provide a wealth of insight into a variety of topics in epilepsy. This episode features Dr. Halley Alexander in conversation with Drs. Emanuela Voinescu, Ezequiel Gleichgerrcht, Nishant Sinha, and Alison Pack on seizure frequency during pregnancy and postpartum, the anatomy of surgical lesions and outcomes in temporal lobe epilepsy, predicting seizure recurrence via brain networks, and the AAN Guideline Subcommittee's practice advisory for antiseizure medication withdrawal, respectively.

Dr. Jeff Ratliff discusses the suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide with Drs. Jonathan Watts and Robert Brown.

Dr. Gregg Day talks with Dr. Avi Nath, Clinical Director of the National Institute of Neurological Disorders and Stroke (NINDS), about COVID brain fog and other cognitive syndromes. Read the full article referenced in this podcast in the Washington Post.

Dr. Justin Abbatemarco talks with Prof. Sarosh Irani about the use of corticosteroids as a first-line agent in the treatment of LGI1 antibody encephalitis.

Dr. Gregg Day talks with Dr. Walter Koroshetz, Director of the National Institute of Neurological Disorders and Stroke, about NINDS's mission and clinical neurology.

Dr. Jeff Burns talks with Dr. Ron Petersen, Director of the Mayo Clinic Alzheimer's Disease Research Center, about Medicare's recent decision to officially limit Aduhelm (aducanumab) coverage to patients in clinical trials. Read the full article discussed in this interview in the New York Times.

Dr. Karen Hirsch talks with Dr. Linnéa Grindegård about the association between EEG patterns and serum neurofilament light as a marker of neuroaxonal injury after cardiac arrest. Read the full article in Neurology.

Drs. B.J. Hicks and Andy Southerland talk with Dr. Scott Mendelson about racial and ethnic disparities in the rates of declination of thrombolysis in patients with acute ischemic stroke. Read the full article in Neurology.

Dr. Justin Abbatemarco talks with Prof. Gráinne Gorman about the use of L-arginine in the treatment of mitochondrial encephalopathy, lactic acidosis, and strokelike episodes (MELAS). Read the full article in Neurology.

Dr. Fábio Nascimento talks with Dr. Elaine Pang about the identification and characterization of pure sleep epilepsy after first-ever seizures from sleep in adults. Read the full article in Neurology.

The June 2022 replay of past episodes showcases a selection of interviews about the impact of the FDA's approval of aducanumab for the treatment of Alzheimer disease (AD). This episode features illuminating conversations with Drs. Gregg Day, Ron Petersen, and Jason Karlawish on the clinical science guiding amyloid-based treatments for AD, the importance of patient participation when considering the use of aducanumab, and the business of Alzheimer disease, respectively. This month's Recall concludes with an interview featuring Pulitzer Prize-winning journalist Pam Belluck on Medicare's limitations on aducanumab coverage.

Dr. Jeff Ratliff talks with Dr. Meredith Bock about the association of motor, non-motor, and behavioral symptoms with health-related quality of life in people with Parkinson disease. Read the full article in Neurology.

In the second part of our two-part series on neurodegeneration in professional football players, Dr. Shuvro Roy talks with Dr. Ann McKee about her career and work studying the consequences of repetitive traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE). For more information on the VA-BU-CLF Brain Bank at the Boston University CTE Center, including brain donation inquiries, click here.

Dr. Justin Abbatemarco talks with Dr. Ming Lim about the diagnosis and management of opsoclonus myoclonus ataxia syndrome (OMAS) in children. Read the full article in Neurology: Neuroimmunology & Neuroinflammation.

In the first part of our two-part series on neurodegeneration in professional football players, Dr. Shuvro Roy talks with Dr. Ann McKee about the high incidence and mortality rates of amyotrophic lateral sclerosis (ALS) in NFL athletes. For more information on the VA-BU-CLF Brain Bank at the Boston University CTE Center, including brain donation inquiries, click here.

Dr. Derek Stitt talks with Dr. Anne Oaklander about the association of long COVID with incident polyneuropathy affecting the small-fiber axons. Read the full article in Neurology: Neuroimmunology & Neuroinflammation.

Dr. Halley Alexander talks with Dr. Shóbi Sivathamboo about the incidence of serious cardiac arrhythmias detected by subcutaneous cardiac monitors in patients with chronic drug-resistant epilepsy. Read the full article in Neurology.

Dr. Jeff Ratliff talks with Dr. Andreas Rowald about the efficacy of activity-dependent spinal cord neuromodulation, which was shown to rapidly restore trunk and leg motor functions in patients with spinal cord injury after complete paralysis.

Dr. Stacey Clardy discusses the prognostic factors and efficacy of immunosuppressive treatments for spinal cord sarcoidosis with Dr. Antoine Gavoille. Read the full article in Neurology.

Dr. Justin Abbatemarco talks with Dr. Bruce Bebo about the estimated economic burden of multiple sclerosis in the US, highlighting direct and indirect cost drivers. Read the related article in Neurology. Please be sure to check out the National Multiple Sclerosis Society's "MS Navigator" resource, which connects patients with MS and their family members to experts who can help them navigate the challenges of MS, from making workplace accommodation requests to case management assessments.

The May 2022 replay of past episodes showcases a selection of interviews about autoimmune neurologic diseases of the central nervous system. This episode features illuminating conversations with Drs. Josep Dalmau, Jérôme Honnorat, and Carles Gaig on the clinical evaluation of first episode psychosis, GFAP autoimmune syndrome, and anti-IgLON5 disease, respectively, as well as a suite of clinical pearls for each syndrome. This month's Recall concludes with a useful series from Dr. Justin Abbatemarco on navigating instances when autoantibodies are not clearly correlated with a distinct clinical syndrome.

Dr. Jeff Ratliff talks with Dr. Michael Fox about the association of connectivity between brain networks and sites of deep brain stimulation (DBS) with DBS-induced cognitive decline in patients with Parkinson disease. Check out the free clinical tool designed to help DBS programmers based on the research discussed in this episode here.

Dr. Halley Alexander talks with Dr. Mark Keezer about the risk of sudden death and cardiac arrhythmia in patients utilizing lamotrigine to treat epilepsy. Read the full article in Neurology.

Dr. Gregg Day talks with Dr. Walter Koroshetz, Director of NINDS, about research recommendations, priorities, and outcomes at the 2022 Alzheimer's Disease-Related Dementias (ADRD) Summit.

Dr. Jason Crowell talks with Dr. Gregg Day about amyloid-targeting treatments for Alzheimer disease as well as how to navigate conversations about aducanumab with patients.

Dr. Jeff Ratliff talks with Drs. Howard Colman and Kelly Fritz about the availability of lomustine for the treatment of glioblastoma multiforme (GBM) in light of the drug's recent withdrawal from Medicare Part D coverage.

Dr. Tesha Monteith talks with Dr. Barbara Decker about maternal obstetric complications and non-elective postpartum readmissions in women with prior stroke, migraine, multiple sclerosis, and myasthenia gravis. Read the full article in Neurology.

Dr. Justin Abbatemarco talks with Dr. Aurora Pujol about diagnosing genetic white matter disorders by singleton whole-exome and whole-genome sequencing using interactome-driven prioritization. Read the full article in Neurology.

Dr. Tesha Monteith talks with Dr. Todd Schwedt about the treatment of chronic migraine with medication overuse through the patient-centered Medication Overuse Treatment Strategy (MOTS) clinical trial. Read the full article in Neurology.

The April 2022 replay of past episodes showcases a selection of interviews with fellow neurologists about their personal experiences as patients. This episode features illuminating conversations with Drs. Daniel Drubach, Daniel Gibbs, Ted Burns, and Oliver Sacks, offering our listeners essential lessons and insights into the importance of physician empathy.

Dr. Gordon Smith talks with Dr. Charlotte Sumner about spinal muscular atrophy, highlighting the historic milestone reached with three medications receiving FDA approval for the treatment of SMA.

Dr. Jason Crowell talks with Drs. Ariane Lewis and David Magnus about the need to update the Uniform Declaration of Death Act (UDDA), aligning the legal criteria with the medical standards used to determine death by neurological criteria. Read the full article in Neurology.

Dr. Jeff Burns talks with Dr. Lon Schneider about the development of ARIA in the Phase 3 EMERGE and ENGAGE trials that led to the FDA's accelerated approval of aducanumab for the treatment of Alzheimer disease.

Dr. Alex Menze talks with Dr. Raquel Gardner about the development of a clinically-relevant definition of poor cognitive outcome one year after mild traumatic brain injury (mTBI) and whether outcomes can be predicted by baseline clinical variables. Read the full article in Neurology.

This episode features Dr. Stacey Clardy in conversation with the 2022 Ted Burns Humanism in Neurology Award Winner, Dr. Barbara Giesser.

Dr. Gregg Day talks with Dr. Niklas Mattsson-Carlgren about the correlation of cerebrospinal fluid biomarkers with autopsy-confirmed Alzheimer disease and frontotemporal lobar degeneration. Read the full article in Neurology.

Dr. Shuvro Roy talks with Dr. Alberto Ascherio about the association of Epstein-Barr virus infection and increased risk of multiple sclerosis, highlighting stronger evidence for this viral connection.

Dr. Jeff Ratliff talks with Dr. Christos Ganos about the use of brain lesion network mapping to interrogate whether tic disorder-inducing lesions are associated with a common network in the average human brain.

Dr. Jason Crowell talks with 46brooklyn Research CEO Antonio Ciaccia about how Medicare Part D has hidden the benefits of generic competition for Tecfidera, a disease-modifying therapy for multiple sclerosis. Read the full article at 46brooklyn.com.

The March 2022 replay of past episodes showcases a selection of interviews regarding the prognosis and treatment of Guillain-Barré syndrome. This episode features Drs. Ted Burns, Jeff Ratliff, and Michelle Mauermann in conversation with Dr. Bart Jacobs over the course of a decade, highlighting the progress he and his team have made in treating and predicting outcomes in GBS over time.

Dr. Tesha Monteith talks with Dr. Elizabeth Loder about her editorial on the gender pay gap in academic neurology and its impact on women neurologists as well as the field at large. Read the full article in Neurology.

Dr. Andy Southerland talks with Dr. Daniel Chasman about the shared genetic risk of migraine, stroke, and cervical artery dissection (CeAD), a triad of neurologic disorders with vascular involvement. Read the full article in Neurology: Genetics.

Dr. Halley Alexander discusses whether epilepsy type, seizure location, or antiseizure medications influence seizure frequency during pregnancy and postpartum with Dr. P. Emanuela Voinescu. Read the full article in Neurology.

Dr. Stacey Clardy discusses the clinical, biological, and imaging features—as well as the overall clinical course—of a French cohort of patients with glial fibrillar acidic protein (GFAP) autoantibodies with Dr. Jérôme Honnorat. Read the full article in Neurology.

Dr. Justin Abbatemarco talks with Dr. Daniel Hartung about the impact of Medicare Part D plan disease-modifying therapy restrictiveness upon adherence and outcomes among patients with multiple sclerosis. Read the full article in Neurology: Clinical Practice.

Dr. Jeff Ratliff talks with Dr. Bart Jacobs about his study on the validity and region-specificity of the modified Erasmus GBS Outcome Score in predicting the risk of walking inability in patients with Guillain-Barré syndrome. Read the full article in Neurology.

Dr. Stacey Clardy interviews behavioral neurologist Dr. Daniel Drubach about his experience with being diagnosed with Lewy body dementia, highlighting the unique perspective his diagnosis has provided him as a physician and as a patient. Read Dr. Drubach's special article in Continuum: "Twilight and Me: A Soliloquy."

Dr. Gordon Smith discusses the AAN Guideline Subcommittee's updated Practice Guideline for the oral and topical treatment of painful diabetic neuropathy with Drs. Raymond Price and Brian Callaghan.

The February 2022 replay of past episodes showcases a selection of interviews regarding the diagnosis and treatment of immune-mediated neuropathies. This episode features Drs. Stacey Clardy and Ted Burns in conversation with Drs. Luise Appeltshauser, Shahar Shelly, and P. James B. Dyck, offering listeners essential insight into the identification and management of acute autoimmune neuropathy, chronic immune sensory polyradiculopathy, and lumbrosacral radiculoplexus neuropathy.