Neurology® Podcast

The December 2024 replay wraps up the year with five previously posted episodes on autoimmune neurology. The episode begins with Drs. Michael R. Wilson and John Pluvinage discussing transcobalamin antibodies. The episode leads into an interview with Dr. Andrew McKeon, who talks about paraneoplastic CAMKV autoimmune encephalitis. In the third episode, Dr. Maarten Titulaer discusses long-term outcomes and rehab in NMDAR encephalitis. The episode continues with Prof. Zsolt Illes discussing the mortality of patients with AQP4 antibody–seropositive neuromyelitis optica spectrum disorder compared with that in the general population. In the final episode, Drs. Marius Ringelstein and Ilya Ayzenberg discuss the effectiveness and safety of Eculizumab in routine clinical care. Podcast Links: Transcobalamin receptor Antibodies in Autoimmune Vitamin B12 Central Deficiency Paraneoplastic CAMKV Autoimmune Encephalitis Long-Term Outcomes and Rehabilitation in Anti-NMDAR Encephalitis Mortality in a Danish NMO Cohort Eculizumab Use in Neuromyelitis Optica Spectrum Disorders Article Links: Transcobalamin Receptor Antibodies in Autoimmune Vitamin B12 Central Deficiency Paraneoplastic Calmodulin Kinase-Like Vesicle-Associated Protein (CAMKV) Autoimmune Encephalitis Long-Term Cognitive, Functional, and Patient-Reported Outcomes in Patients With Anti-NMDAR Encephalitis Mortality of the Danish Nationwide AQP4 Antibody-Seropositive Neuromyelitis Optica Spectrum Disorder Patient Cohort Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data From a European Cohort Disclosures can be found at Neurology.org.

Dr. Halley Alexander talks with Dr. Vineet Punia about factors influencing the decision to continue or discontinue anti-seizure medications at discharge for patients hospitalized with acute symptomatic seizures. Read the related article in JAMA. Disclosures can be found at Neurology.org.

Dr. Stacey Clardy talks with Dr. Catherine Albin about the key features of educational social media posts, strategies for creating impactful content, the importance of visual appeal, and the role of community engagement in neurology education. Read the related article in Neurology: Education. Disclosures can be found at Neurology.org.

Dr. Justin Abbatemarco talks with Dr. Maarten Titulaer about long-term cognitive and functional outcomes in patients with anti-NMDAR encephalitis and their implications for rehabilitation. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Stacey Clardy talks with Dr. Elias Sotirchos about the underlying etiologies of myelitis in patients with rheumatologic disease. Read the related article in Neurology: Neuroimmunology & Neuroinflammation. Disclosures can be found at Neurology.org.

Dr. Gregg Day talks with Dr. Kathryn T. Hall about the complexities of the placebo effect, its variability among patients, and the genetic factors that influence responses to placebo treatments. Disclosures can be found at Neurology.org.

Dr. Justin Abbatemarco talks with Dr. Ahmad Nehme about the complexities of diagnosing and differentiating between cerebral amyloid angiopathy-related inflammation and biopsy-positive primary angiitis of the central nervous system. Read the related article in Neurology. Disclosures can be found at Neurology.org.

In the concluding segment of this two-part series, Dr. Justin Abbatemarco talks with Dr. Jennifer L. Orthmann-Murphy about genetic leukodystrophies and the increasing recognition of these disorders in adult neurology, the importance of genetic testing, and the evolving treatment landscape. Read the related articles in Neurology and CHS Perspectives. Disclosures can be found at Neurology.org.

In the first part of this two-part series, Dr. Justin Abbatemarco talks with Dr. Jennifer L. Orthmann-Murphy about a practical approach to genetic leukodystrophies, focusing on the importance of genetic testing, identifying red flags in patients, and navigating the complexities of hereditary spastic paraplegia. Read the related articles in Neurology and CHS Perspectives. Disclosures can be found at Neurology.org.

The November 2024 replay features four episodes dedicated to brain health. It kicks off with an interview with Dr. Nicoline Schiess, who discusses the World Health Organization (WHO) Brain Health Unit. Next, Dr. Katrin Seeher delves into the global burden of neurological conditions and the WHO's strategies to enhance care and awareness. The third segment features Dr. Natalia Rost who introduces and highlights the American Academy of Neurology's (AAN) groundbreaking brain health initiative. The episode wraps up with Dr. Rost again, who returns to give an update and emphasize the urgency of addressing brain health amidst public health challenges. Podcast Links: WHO Brain Health Unit Global Burden of Neurologic Conditions Brain Health Initiative with Dr. Natalia Rost Update on Brain Health with Dr. Natalia Rost Article Links: Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 The Brain Health Imperative in the 21st Century—A Call to Action AAN Brain Health Initiative Disclosures can be found at Neurology.org.

Dr. Justin Abbatemarco talks with Drs. Marius Ringelstein and Ilya Ayzenberg about the effectiveness and safety of Eculizumab in routine clinical care. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Tesha Monteith talks with Drs. Messoud Ashina and Andrea Cipriani about all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults. Read the related article in the BMJ. Disclosures can be found at Neurology.org.

Dr. Greg Cooper talks with Dr. Clifford R. Jack Jr about objective criteria for diagnosis and staging Alzheimer disease, highlighting recent advancements in biomarkers to bridge the gap between research and clinical practice. Read the related article in Alzheimer's Association. Disclosures can be found at Neurology.org.

Dr. Gordon Smith talks with Dr. Whitley Aamodt about end-of-life care for patients with neurodegenerative diseases, focusing on healthcare utilization, hospice enrollment, and the importance of early conversations about care preferences. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Kait Nevel talks with Dr. Oumaima Aboubakr about the prevalence of epilepsy in primary CNS lymphoma, to identify factors associated with epilepsy, and to investigate the prognostic significance of seizures in PCNSL. Read the related article in Neurology®. Disclosures can be found at Neurology.org.

In the final part of this three-part series, Dr. Stacey Clardy talks with Drs. Elisabeth Bik and Matthew Schrag about the challenges posed by AI in generating fraudulent research, the importance of cultural solutions to uphold scientific integrity, and the need for modernized data management practices in research. Read the related article in Undark. Disclosures can be found at Neurology.org.

In part two of this special three-part series, Dr. Stacey Clardy talks with Drs. Elisabeth Bik and Matthew Schrag about the processes involved in addressing concerns about research integrity, covering the role of public platforms, using social media for awareness, identifying potential research fraud, and the need for cultural change within the scientific community to prioritize ethical practices. Read the related article in Undark. Disclosures can be found at Neurology.org.

In the first part of this special three-part series, Dr. Stacey Clardy talks with Drs. Elisabeth Bik and Matthew Schrag about critical issues surrounding research integrity and misconduct. Read the related article in Undark. Disclosures can be found at Neurology.org.

Dr. Farrah Mateen talks with Dr. Katrin Seeher about the significant global burden of neurologic conditions, which affects over 3.4 billion people worldwide, and the strategies the WHO is implementing to improve care and awareness. Read the related article in The Lancet Neurology. Disclosures can be found at Neurology.org.

In the October 2024 replay features four episodes on approaches to clinical diagnosis of parkinsonism. The episode starts off with Dr. Colin Hoy discuss the concept of prodromal Parkinson disease and the ethical considerations surrounding its diagnosis. The episode leads into a conversation with Dr. Chris Gibbons discussing skin biopsies to detect phosphorylated α-synuclein. In the third episode Drs. Michiko K. Bruno and Lawrence Golbe about a practical diagnostic algorithm for atypical parkinsonian disorders Drs. Michiko K. Bruno and Lawrence Golbe discuss a practical diagnostic algorithm for atypical parkinsonian disorders. The episode concludes with Dr. Eduardo De Pablo-Fernández talking about the strengths of DAT imaging in diagnosing patients with Parkinsonian disorders. Previous Podcasts: The Ethical Landscape of Prodromal Parkinson Disease Skin Biopsy Detection of Phosphorylated α-Synuclein General Neurologist's Practical Diagnostic Algorithm for Atypical Parkinsonian Disorders Interpreting DAT Imaging Results in the Clinical Context Article Links: The Ethical Landscape of Prodromal Parkinson Disease Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies A General Neurologist's Practical Diagnostic Algorithm for Atypical Parkinsonian Disorders Neuropathologic Validation and Diagnostic Accuracy of Presynaptic Dopaminergic Imaging in the Diagnosis of Parkinsonism Disclosures can be found at Neurology.org.

Dr. Jeff Ratliff talks with Drs. Nanditha Rajamani and Andy Horn about the challenges faced in current deep brain stimulation practices and the potential for data-driven approaches to enhance treatment outcomes. Read the related article in Nature Communication. Disclosures can be found at Neurology.org.

Dr. Shuvro Roy talks with Dr. Anne Louise Oaklander about the big-picture takeaways for clinicians in the context of managing small-fiber neuropathy. Read the related article in Neurology® Neuroimmunology & Neuroinflammation. Disclosures can be found at Neurology.org.

Dr. Dara Albert talks with Dr. Jaclyn M. Martindale about the differences in gender representation among leadership positions and award recipients within the Child Neurology Society. Read the related article in Neurology®. Disclosures can be found at Neurology.org.

Dr. Jeff Ratliff talks with Drs. Michiko K. Bruno and Lawrence Golbe about a practical diagnostic algorithm for atypical parkinsonian disorders, emphasizing the importance of recognizing these conditions in clinical practice. Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org.

Dr. Gordon Smith talks with Drs. Shahar Shelly and Teerin Liewluck about the correlation between CMAP duration and myosin loss and their effect on mortality by comparing between patients with CIM with and without myosin loss. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Tesha Monteith talks with Dr. Messoud Ashina about the biology of PACAP, its significance in relation to migraines, and its potential as a novel therapeutic approach. Read the related article in The New England Journal of Medicine. Disclosures can be found at Neurology.org.

Dr. Amy Gelfand talks with Dr. Matthew Bender about the possible association between glymphatic outflow and extent of transverse sinus stenosis in patients with intracranial hypertension. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. David Perez talks with Dr. Glenn Nielsen about the effectiveness of physiotherapy in treating functional motor disorder and to determine the best approach for physiotherapy treatment. Read the related article in The Lancet. Disclosures can be found at Neurology.org.

Dr. Stacey Clardy talks with Dr. Mary Schroth about the revised SMA recommendations, treatment options available, treatment outcomes, and the future of SMA research and care. Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org.

The September 2024 recall features previously posted Neurology Minute episodes by Dr. Alison Christy, focusing on Women in History Minutes. Dr. Christy has curated an outstanding series highlighting numerous women and their significant contributions to the field of neurology. In honor of Women in Medicine Month, we've compiled some of the best moments from her series to celebrate these remarkable pioneers. Tune in to celebrate the remarkable contributions of these women and their lasting impact on the medical field. Mary Putnam Jacobi Eliska Klimkova-Deutschova Dorothy Russell Louise Eisenhardt Rita Levi Montalcini Sarah McNutt Augsta Dejerine-Klumpke Forence Rena Sabin Kinuko Suzuki Marian Molly Putnam Ema Gibbs Mary Broadfoot Walker Isabelle Rapin Mary Spink and Alice Bennett Marie Joubert Mary Anne Guggenheim Disclosures can be found at Neurology.org.

Dr. Gregg Day talks with Dr. Sebastian Palmqvist about the use of blood biomarkers to streamline the diagnostic workup and treatment of Alzheimer disease. Read the related article in JAMA. Disclosures can be found at Neurology.org.

Dr. Jeff Ratliff talks with Dr. Calum Alexander Hamilton about the importance of tracking and managing patients with MCI, especially those with Lewy body pathology. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Stacey Clardy talks with Dr. Nicola de Souza about neuropsychological profiles of deployment-related mild traumatic brain injury and post-traumatic stress disorder among service members and veterans. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Jeff Ratliff talks with Dr. Daniel Weintraub about the long-term dementia risk in Parkinson disease using data from two large, ongoing, prospective, observational studies. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Jeff Ratliff talks with Dr. Eduardo De Pablo-Fernández about the strengths of DAT imaging in diagnosing patients with Parkinsonian disorders. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Dan Ackerman talks with Dr. Luciano A. Sposato about the topic of embolic stroke of undetermined source and the controversies surrounding cardiac monitoring and anticoagulation. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Dan Ackerman talks with Dr. Gaspard Gerschenfeld about the efficacy and safety of both thrombolytics in patients with large ischemic core. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Jason Crowell talks with Dr. Colin Hoy about the concept of prodromal Parkinson disease and the ethical considerations surrounding its diagnosis. Read the related article in Neurology. Disclosures can be found at Neurology.org.

The August 2024 recall showcases four previously posted episodes on the topic of Multiple Sclerosis. In the first episode, Dr. Géraldine Androdias discusses the impact of immune checkpoint inhibitors on multiple sclerosis. The episode leads into Dr. Bob Fox discussing the relationship between sNfL levels and radiologic activity in multiple sclerosis. In the third episode, Dr. Ellen Iacobaeus discusses the clinical characteristics of late-onset multiple sclerosis. The last episode leads into a conversation with Dr. Riley Bove discussing navigating family planning and pregnancy in patients with multiple sclerosis. Article Links: Impact of Immune Checkpoint Inhibitors on the Course of Multiple Sclerosis Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis Clinical Characteristics and Long-Term Outcomes of Late-Onset Multiple Sclerosis: A Swedish Nationwide Study Multiple Sclerosis and Family Planning: A Survey Study of the Patient Experience Podcast Links: Impact of Immune Checkpoint Inhibitors sNfL and Radiologic Disease Activity in Patients With MS Clinical Characteristics and Long-Term Outcomes of Late-Onset MS Multiple Sclerosis and Family Planning Disclosures can be found at Neurology.org.

Dr. Halley Alexander talks with Dr. Kimford J. Meador about perinatal exposure to anti-seizure medications and its effects on creativity and executive function in children. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Matthew Barrett talks with Dr. Michael S. Okun about the caution and deliberation needed in understanding Parkinson disease biomarkers. Read the related viewpoint piece in JAMA Neurology. Disclosures can be found at Neurology.org.

Dr. Andy Southerland talks with Dr. Lidia Moura about the implications of large language models (LLMs) for neurologic care. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Justin Abbatemarco talks with Drs. Michael R. Wilson and John Pluvinage about their discovery of anti-CD320 antibodies in patients with neurologic manifestations of B12 deficiency and discuss the potential implications for diagnosis and treatment. Read the related article in Science. Disclosures can be found at Neurology.org.

Dr. Jason Crowell talks with Dr. Campbell Le Heron about the association of clinical and neurocognitive factors with apathy in patients with Parkinson disease. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Justin Abbatemarco talks with Dr. Andrew McKeon about the topic of autoimmune neurology, specifically focusing on the antibody CAMKV and its association with autoimmune encephalitis. Read the related article in Annals of Neurology. Disclosures can be found at Neurology.org.

Dr. Jessica Ailani talks with Dr. Ian Carroll about intracranial hypotension, the challenges of diagnosing and treating patients with CSF leaks, and the study's findings. Read the related article in Neurology. This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information. Disclosures can be found at Neurology.org.

As part of our "Physician as Patient" series, Dr. Andy Southerland talks with Dr. Eric Seachrist about his experience with multiple sclerosis. This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information. Disclosures can be found at Neurology.org.

Dr. Stacey Clardy talks with Dr. Carlayne E. Jackson about the state of neurology and the challenges and opportunities facing the field. This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information. Disclosures can be found at Neurology.org.

Dr. Andy Southerland talks with Dr. Seemant Chaturvedi about recent trials presented at the European Stroke Organization Conference. Show references: Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without Thrombectomy Rationale and Design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III) Colchicine for Prevention of Vascular Inflammation in Non-CardioEmbolic Stroke (CONVINCE) Intensive Ambulance-Delivered Blood- Pressure Reduction in Hyperacute Stroke This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information. Disclosures can be found at Neurology.org.

The July 2024 replay of past episodes showcases four incredible interviews on infectious and post-infectious neurology. The episode begins with Dr. Alice Tang discussing the association between immune status and herpes simplex virus encephalitis. The episode leads into Dr. Haya Bishara talking about GBS and COVID-19 infection. In the third episode, Dr. Adam de Havenon talks about neurologic diagnoses in the year after COVID-19 vs. Influenza. The episode concludes with Dr. Avindra Nath talking about new research related to post-infectious myalgic encephalomyelitis/chronic fatigue syndrome. Article Links: Herpes Simplex Virus Encephalitis in Patients With Autoimmune Conditions or Exposure to Immunomodulatory Medications Burden of Neurologic Health Care and Incident Neurologic Diagnoses in the Year After COVID-19 or Influenza Hospitalization Association Between Guillain-Barré Syndrome and COVID-19 Infection and Vaccination A Population-Based Nested Case-Control Study Podcast Links: Herpes Simplex Virus Encephalitis Guillain-Barré Syndrome and COVID-19 Infection and Vaccination Neurologic Diagnoses after COVID-19 or Influenza Hospitalization Post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Disclosures can be found at Neurology.org.