The Lab Report

Eating disorders have long been stigmatized and treatments have been limited – until now. Dr. Michael Lutter is a medical psychiatrist and PhD researcher working toward new solutions and therapies to offer hope for those suffering with psychiatric illness. Using the latest advancements in genetic and metabolic testing, Dr. Lutter helps patients understand how their unique biology plays a role in their psychiatric disease and tailors treatment based on these findings. His results are astounding. His latest book GIFTED: Genetic Information for Treating Eating Disorders outlines his novel approach. In today’s episode, Dr. Michael Lutter discusses precision psychiatry and the role of genetic and metabolic testing for personalized results. Today on The Lab Report: 5:30 Meet Dr. Michael Lutter and learn about whole exome sequencing 10:15 Genetic mutations in eating disorders and metabolic effects 14:00 Nutritional therapy and the NutrEval in psychiatry 18:00 Using the GIFTED approach in practice for eating disorders 23:30 Removing stigmas and shifting the paradigm 27:55 Other testing -Vitamin D, the microbiome, hormones, oxidative stress, and the brain 32:30 Genetic mutation overlaps with OCD and addition 35:00 Dr. Lutter’s long path and getting the field to catch up 41:30 The Fireball Additional Resources: Precision Psychiatry GIFTED: Genetic Information For Treating Eating Disorders Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Elite professional athletes are often held up as the healthy ideal. But many of us don’t realize the wear and tear and physical toll that sport takes on the body. That’s where Jaclyn Sklaver comes in. As a nationally recognized sports nutrition specialist, she combines functional medicine with personalized nutrition to create coaching plans for long-term success. Today we meet Jaclyn Sklaver and hear about her unique Athleats Nutrition program. Whether you are an elite athlete or an everyday gym enthusiast, Jaclyn’s team at Athleats Nutrition can help you reach peak performance, optimal body composition, and realize strength and recovery goals. Today on The Lab Report: 4:10 Jaclyn Sklaver on challenges and variables in helping elite athletes 7:30 Quality calories and food volume in training 9:45 Metabolic dysfunction, injury and repair, hormonal imbalances 12:50 Nutrition as a secret weapon 15:15 Functional nutrition and microbiome testing 20:45 Weight loss advice 23:40 Training and the importance of recovery 31:30 Athleats Nutrition 33:10 The Fireball Additional Resources: Athleats Nutrition Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Autoimmune conditions are exponentially on the rise. Toxic exposures, declining food quality, stress, and unhealthy lifestyle factors are all contributors. Dr. Akil Palanisamy is a Harvard-trained physician, author, and holistic medicine expert in integrative and functional medicine. Through years of experience in root-cause medicine, he’s helped thousands of patients find relief and remission of autoimmune diseases. Dr. Akil’s new book The T.I.G.E.R. Protocol: An Integrative, 5-Step Program to Treat and Heal Your Autoimmunity outlines his approach using the best of conventional and holistic medicine. In today’s episode, we meet Dr. Akil Palanisamy. We discuss his treatment strategies and successes in addressing autoimmunity as outlined in his new book The T.I.G.E.R. Protocol. Today on The Lab Report: 3:45 Akil Palanisamy combines integrative and holistic medicine with Ayurveda 7:20 Common misconceptions and the paleovedic diet 8:25 The rise of autoimmunity – remission vs. cure 10:35 The T.I.G.E.R. Protocol – autoimmunity treatment and prevention 14:06 Exposome and detox 15:35 Infection, gut health, and autoimmunity 20:00 Phase 1 - Phase 2 Diet, processed food quality 24:30 Rest, recovery, and stress 26:00 Success stories, mitigating pharmaceuticals, remission 27:35 The Fireball Additional Resources: The T.I.G.E.R. Protocol doctorakil.com Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Melatonin is known as the sleep hormone, but it is SO much more than that. Yes, it is produced in the brain and controls the day/night cycle. However, what many people don’t realize is that is also produced in other places in the body such as the gastrointestinal tract, skin, bone marrow, and more where it exerts important local effects that are important for health. Additionally, it is a powerful antioxidant making it crucial in mitigating harmful free radical damage which is implicated in aging and many chronic diseases. In today’s episode, we break down the synthesis, physiology, and metabolism of melatonin. We discuss not only melatonin’s role in day/night cycles, but its important systemic effects to promote health and mitigate harmful risks. Today on The Lab Report: 2:40 Melatonin is an important hormone 6:30 Break it down: melatonin and day/night cycles 9:00 Babies and sleep 10:30 Suprachiasmatic nucleus and blindness 11:30 Sleep, shift workers, jet lag 14:30 Systemic antioxidant effects 16:10 Melatonin in the GI tract 17:40 Brain health, cancer, cardiovascular disease, and other hormones 21:00 Supplementation and side effects 23:25 Question of the Day Does melatonin supplementation affect nutrition testing? Additional Resources: Comprehensive Melatonin Profile One Day Hormone Check Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.See omnystudio.com/listener for privacy information.

If you’ve seen the Netflix documentary “The Social Dilemma,” you’ll recognize today’s guest. Dr. Anna Lembke is an addiction specialist from Stanford University, a New York Times best-selling author, and was featured on that Netflix special. Addiction takes many forms – not only alcohol and illicit drugs, but also social media, exercise, shopping, and workaholism. But, where’s the line between habit and addiction? What can we do to reset our brain chemistry? In this episode, Dr. Lembke explains dopamine’s role in our brain’s reward system. We discuss addiction in its many forms, social media, and strategies to rewire dopamine pathways. Today on The Lab Report: 3:00 Anna Lembke explains dopamine and the reward system 6:05 Dopamine hits in today’s society 10:40 Moderation vs. Abstinence 13:30 Social media and children 15:00 Does society award addictive behavior? 18:45 Long term dopamine dysfunction and Parkinson’s disease 22:00 Parenting in the digital age 27:20 The Fireball Additional Resources: annalembke.com Dopamine Nation Drug Dealer, MD The Social Dilemma Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Dr. Sheila Dean is one of the nation’s premier integrative nutritionists. She is a co-founder of the Integrative and Functional Nutrition Academy and has practiced functional medicine for two decades. Her insight has not only changed the lives of many patients, but her teaching and mentoring has inspired and empowered a new generation of nutrition specialists and health professionals. In today’s episode, we welcome Dr. Sheila Dean back to the show for a masterclass in hormone detoxification – including the importance of testing and clinical pearls using nutritional therapeutics. Today on The Lab Report: 3:20 Dr. Dean is back with a detox pathway recap 7:20 Importance of hormone detox 11:10 The need for testing metabolites 16:30 Clinical pearls for optimizing estrogen metabolism 21:45 Role of Genetic SNPs and the microbiome 28:30 IFNA program highlights 30:35 The Fireball Additional Resources: Integrative and Functional Nutrition Academy Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

After years of working with collegiate and professional athletes, Pratik Patel has gained significant wisdom when it comes to optimal health. The continuous strain placed on the body of professional athletes can take its toll. Keeping those athletes healthy is no easy task. Pratik has worked with some of the most elite athletes in the world. In today’s episode, dietitian and conditioning coach, Pratik Patel, reflects on his years in the NFL and imparts his wisdom regarding nutrition, hydration, strength training, recovery, and overall athletic health. Today on The Lab Report: 4:00 Pratik Patel on great athletes vs. elite athletes 8:15 Genetics and work ethic 11:20 Lab testing, does fitness = health? 19:25 Hydration, thirst, and performance 25:00 Climate adaptability and electrolytes 31:00 Caffeine and hydration 34:00 Diet principles for athletes 38:35 Training pitfalls 41:10 Recommended supplements 49:35 Working with Pratik 51:00 The Fireball Additional Resources: Instagram: @pratikxpatel Twitter: @PratikxPatel Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Interpreting the GI Effects Comprehensive Stool Profile can be complicated. Here at Genova, we do a lot of educational outreach, one-on-one consults, group consults, and we compile lots of support materials to help – support guides, report review videos, charts, and more. Even with that, some clinicians still continue to misinterpret biomarker results and draw conclusions on their own which may not be valid. In today’s episode, we dive into some of the GI Effects’ most common interpretation mistakes to dispel the rumors and help clinicians find the best outcomes for their patients. Today on The Lab Report: 5:00 Products of Protein Breakdown and digestion/absorption 8:30 Commensal bacteria - below detectable limits? 12:20 When to treat a potential pathogen? 13:15 Salmonella pronunciation and etymology 19:15 Misusing Add-ons 22:50 Beta-glucuronidase and calcium-d-glucarate Additional Resources: GI Effects Support Guide Commensal Bacteria Chart Parasitic Organisms Chart Pathogenic Bacteria and Yeast Chart GI Effects Report Review Video Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Amino acids are the building blocks of life. They can be categorized as essential or nonessential. Essential amino acids must come from the diet, while nonessential amino acids can be made in the body. Of the essential amino acids, there is a subgroup called the ‘branched-chain amino acids (BCAAs).’ There are three BCAAs: leucine, isoleucine, and valine. These three amino acids have different molecular structures and important metabolic activity. In this episode, we discuss the clinical importance of BCAA and how to interpret BCAA levels in context with organic acids. Today on The Lab Report: 2:50 Let’s Define Some Terms! 5:10 The unique metabolism of BCAAs 6:30 BCAAs effects on the brain, muscle, and insulin resistance 12:30 What do we think we know? BCAAs and immunity 16:10 Measuring and interpreting amino acid patterns 17:55 Relating BCAA levels to urinary organic acids 21:00 Logical Speculation: Urinary alpha-keto acids and ketosis Additional Resources: NutrEval Metabolomix + Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

In last week’s episode, we did a high-level review of nutrient testing – who might need it and why. We also introduced you to Genova’s Metabolomix+ profile. This nutritional profile is a non-invasive at-home collection with easy, actionable nutrient recommendations you can start implementing right away tailored for your personal metabolic fingerprint! Today we dive a bit deeper into the biochemistry and biomarkers that are measured on the Metabolomix+ profile which contribute to the nutrient recommendations. Functional assessments, organic acids, amino acids, fatty acids, oxidative stress, and more! Today on The Lab Report: 3:15 Recap of last episode Metabolomix overview and introducing the MHR Masterclass 6:00 Krebs Cycle and cellular energy 8:45 Organic Acids and functional assessments 11:20 Amino acids – essential, non-essential, and amino acid metabolism 14:30 Essential and Metabolic Fatty acids 16:10 Better Know a Biomarker DGLA and the inflammatory cascade 23:15 Urine Toxic Elements Additional Resources: Genova Connect - Metabolomix+ Register Here for the Metabolic Health Revolution Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

We know nutrition is important. But with all of the confusion around different diet camps out there, (Mediterranean, paleo, vegetarian, keto) many of us don’t know where to start. How do we know if we’re getting proper nutrition to keep us healthy? Are you keeping up with how your body uses nutrients due to exercise, growth, or wound healing? Is a nutrient insufficiency causing your depression or fatigue? Are you setting yourself up for cellular stresses and potentially chronic disease? Food diaries can help but sometimes they fall short. Here’s where testing can help. Today we discuss the power of Genova’s Metabolomix+. This nutritional profile is a non-invasive at-home collection with easy, actionable recommendations you can start implementing right away tailored for your personal metabolic fingerprint! Today on The Lab Report: 3:15 Who needs a nutrition test? 6:00 Intro to the Metabolomix+ Profile 8:45 Nutrition underpins bodily functions 12:25 Personalized nutrient recommendations 14:40 Education and food sources on the report 17:20 Question of the Day Do I have to stop my supplements to do testing? Additional Resources: Genova Connect - Metabolomix+ Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Rachel Gregory is a board-certified nutrition specialist, strength and conditioning coach, podcaster, author, and founder of MetFlex Life. She inspires and guides women to transform their lives through proper education, awareness, and accountability in nutrition and fitness. Through her unique approach, she helps women all across the world learn how to ditch the restrictive all-or-nothing mindset and instead thrive through the power of metabolic flexibility. In today’s episode, Rachel Gregory returns to the show and we catch up on her amazing coaching programs, education, and her latest insights relating to women’s health. Today on The Lab Report: 4:00 Rachel Gregory is back, and she’s been busy!! 8:35 Change of focus to holistic women’s health and common pitfalls 15:00 Using keto as a tool vs. pulsating carbs 18:40 Long-term planning and periodization 21:00 Training to build muscle instead of weight loss 24:25 Wearable devices 27:05 The role of carbohydrates 29:40 Correctly building muscle 37:40 Will there be another book? 38:50 The Fireball Additional Resources: MetFlex Life TheFlexFam Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

There is a lot of debate and controversy when it comes to nutrition. Many of us are entrenched in our diet camps and with that, some nutrients are unfairly vilified. One such nutrient is phytoestrogen. Phytoestrogens are chemical compounds found in plants that can stimulate and block estrogen receptors in the body – a concept that is poorly misunderstood. In today’s episode, we talk about phytoestrogens and their metabolic function. Should they be classified as anti-nutrients? Are they dangerous or protective? Today on 3:20 Phytoestrogens and anti-nutrients 5:07 Types of phytoestrogens and common food sources 7:55 Are we actually eating estrogen? 9:30 Constituent vs. whole plant 12:00 Hormone-related risks and PMS 13:32 Cardiovascular disease 14:30 Logical Speculation – Just eat food 17:00 Tumors, bone, brain, and skin Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Dr. Sara Gottfried is a key opinion leader as it relates to hormone balance. As a New York Times best-selling author, practicing medical doctor, researcher, university professor, and popular speaker, she offers an evidence-based approach to hormones and nutrition. Her upcoming book “Women, Food, & Hormones” outlines the latest research combined with her vast clinical experience to help women lose weight and get to the root cause of hormonal complaints. In today’s episode, we discuss the interconnection of hormones with diet and the microbiome, and we hear about her approach to bio-identical hormone replacement therapies. Today on The Lab Report: 3:20 Meet Dr. Sara Gottfried and hear her journey to root cause medicine 8:50 Diet, metabolism, and hormones 12:45 Pre-diabetes and continuous glucose monitoring 14:35 Heart rate variability testing and cortisol 17:00 When to use bio-identical hormone replacement 20:20 Cortisol’s effects on other hormones 22:25 The role of the microbiome 25:25 Dosing and timing of hormone replacement 30:50 How you can work with Dr. Gottfried 31:50 The Fireball Additional Resources: saragottfriedmd.com Marcus Institute of Integrative Health Women, Food, & Hormones The Hormone Reset Diet The Hormone Cure Brain Body Diet Younger Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

If there’s one thing we’ve learned, the world of diet and nutrition is full of controversy. People are deeply entrenched in their diet camps and routinely, various nutrients become vilified. Though, it’s never that simple. Today we take on the topic of antinutrients. Antinutrients are plant-made chemicals that bind and potentially prevent the absorption of important vitamins and minerals. The most controversial of these antinutrients is lectin. Lectins are found in beans, peanuts, tomatoes, potatoes, lentils, and many other foods. Some medical influencers advise removing these foods from the diet completely. But is that really necessary? In today’s episode, we discuss the controversy around antinutrients - specifically lectins. Are they as harmful as people think? Today on The Lab Report: 3:00 Food controversies and brass tacks 5:40 What is an antinutrient? 8:00 Lectins and their biochemical effects 11:00 Cooking and denaturing lectins 13:15 Physical symptoms and leaky gut - the research 17:00 Confounding variables 19:00 The middle ground Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Ayurvedic medicine is one of the oldest holistic healing systems. It was developed thousands of years ago in India and is still practiced throughout the world both exclusively and in conjunction with Western medicine. Ayurveda works to find balance between our innate constitution and how we adapt to our world. Dr. Gillian Ehrlich is extensively trained in conventional and functional medicine but also weaves the art of ayurveda through each patient encounter helping to treat the whole patient – body, mind, and spirit. In today’s episode, Dr. Gillian Ehrlich discusses the principles of Ayurveda. We learn how she puts science and art together toward practicing true transformational medicine. Today on The Lab Report: 4:20 Gillian Ehrlich on her path to Ayurvedic medicine 9:30 The three Doshas – Vata, Pitta, Kapha 16:25 Finding your dosha 21:40 Tailoring interventions for each dosha 29:05 Lab testing, ama, and the importance of digestion 37:30 NeuroVeda Health – a unique medical practice 49:45 The Fireball Additional Resources: NeuroVeda Health Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Dr. Molly Maloof has been leading and innovating in the personalized medicine space for years. Her entrepreneurial spirit lends itself to looking at healthcare in very forward-thinking ways. After years of research and clinical practice, she’s finally put all of her knowledge down on paper and is soon to release her new book, “The Spark Factor: The Secret to Supercharging Energy, Becoming Resilient, and Feeling Better Than Ever.” In today’s episode, we meet Dr. Molly Maloof and discuss her unique approach to health, wearable devices, biohacking tips, and the power of “The Spark Factor.” Today on The Lab Report: 4:30 Molly Maloof on her path to personalized medicine 11:30 The Spark Factor 17:45 Wading through biohacking for women - fasting, diets, CGM, HRV 22:55 Using laboratory testing in practice 26:40 Wearable devices – pros/cons 32:40 Listening to intuition, inner wisdom, and body signals 37:55 Love, social connection, and optimal health 45:25 The Fireball Additional Resources: The Spark Factor Dr. Molly Maloof Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Berberine is an alkaloid compound that can be extracted from several plants. It is a widely used supplement in personalized medicine and is also beginning to get some traction within the conventional medicine space. Berberine is mainly used in the GI tract for its antimicrobial effects, but as it relates to gut health, that’s just the tip of the iceberg. What is even more fascinating is berberine’s vast systemic metabolic influences. In today’s episode, we dive into the wide array of berberine’s important effects. Not only on the gut, but also on detoxification systems, skin, eyes, lipid and blood glucose control, hypertension, and cardiovascular health. Today on The Lab Report: 4:00 Berberine – not an herb – where does it come from? 6:55 Overall gut modulator, skin health, and detox 13:05 Metabolic dysfunction – blood glucose, protein, lipids 14:50 Cardiovascular effects and heart health 16:00 Contraindications and safety considerations 18:00 What’s in a name? Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Diet and nutrition are a cornerstone of health and wellness. Small changes can have big impacts! With so much research and so many opinions, many people still struggle with what they should be eating. When looking for help, it’s difficult to wade through the various schools of thought since people become entrenched in their dietary camps: keto, carnivore, vegetarian, Mediterranean, etc. Recent trends have been leaning toward decreasing or eliminating carbohydrates in general. But, if history has taught us anything, vilifying specific food groups can have consequences. Are all carbs bad? If our industry espouses a personalized approach to health, shouldn’t that include diet? In today’s episode, we discuss the good and bad of carbohydrates – and more specifically starch. We discuss the different types of starch and the fact that not all carbs are created equally Today on The Lab Report: 2:25 Why are we vilifying carbohydrates? 5:00 Not all carbs are created equally – let’s talk starch basics 6:45 Starch digestibility and glycemic index 8:30 Slowly digestible and resistant starch 12:00 Effects on the microbiome 15:15 Starchy foods and Retrogradation 19:00 Glycoalkaloids, potato safety, corn starch 21:10 Question of the Day Is there anything nutritious in a potato? Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Another calendar year in the books, and The Lab Report did not disappoint. Incredible interviews with some of the brightest minds in the health care industry, complex medical topics made easy, games, jingles, and loads of fun. As we approach the New Year, it’s a great time to listen back to some of the highlights (and lowlights) from the podcast throughout 2022. On today’s episode, Michael takes a walk down memory lane while Patti is away on vacation – though, despite the distance you can’t separate the dynamic duo. Today on The Lab Report: 2:15 Michael is making his own episode– Better Call Patti!!! 5:30 Jingles, sound effects, and Travis 9:00 Metabolic Health and New Year Resolutions 20:30 Michael’s random life advice, flubs, and the importance of staying curious 30:30 The Lab Report reviews by audience & guests 33:00 Dynamic duo general insanity/nonsense and Michael’s early onset grumpiness 41:30 It's not all shenanigans – we do some important interviews 49:50 Games, grooves, and lack of gravitas 60:00 Practical tips and profundity from our guests 63:30 We talk a lot about animals. Also, we apparently hate insects 69:20 Fireball Fun Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

When it comes to holiday traditions, we think of decorating Christmas trees, baking cookies, the Elf on the Shelf, or lighting a menorah. But holiday traditions are far more unusual and diverse throughout the world. Some might really surprise you! On today’s episode, we touch on some unusual international holiday customs you’ve likely never heard while sprinkling in some clinical pearls. We also continue our podcast tradition of reading The Lab Report’s special rendition of ‘Twas the Night Before Christmas. Today on The Lab Report: 5:00 Kentucky Fried Christmas 7:00 The Christmas Pickle 8:55 Pooping logs, yule goats, & frankincense 14:30 Christmas disease game 17:30 Santa Claus towns 20:00 ‘Twas the Night Before Christmas Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

The roles of nutrition, hormones, and muscle physiology have been well established when it comes to improving athletic performance. But what if optimizing the gut microbiome is a crucial missing piece? This is exactly where Dr. Sara Campbell and her team at Rutgers University focus their research. Dr. Campbell pioneered studying the connection between the microbiome and movement over a decade ago – with fascinating results. In today’s episode, Dr. Sara Campbell discusses the latest research on the effect of exercise on our gut microbiome, how the microbiome can enhance athletic performance, and the emerging paradigm shift highlighting the role of microbial metabolites. Today on The Lab Report: 4:30 Meet Dr. Sara Campbell 8:20 The bidirectional axis between gut bacteria and exercise 14:00 Parsing out the noise in designing research studies 18:00 Antibiotics effects on exercise 21:04 Aerobic exercise, resistance training, HIIT and the microbiome 26:00 Targeted probiotics for athletic performance? 29:30 Bacteria vs. their metabolites 40:10 The Fireball Additional Resources: Dr. Sara Campbell GI Effects + Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

As technology evolves, so too does our understanding of the gut microbiome. Until now, we’ve only seen the tip of the iceberg. Metagenomics offers us the ability to assess the complete microbiome as well as its potential function. This is the technology that powers Genova’s new Microbiomix stool profile and we’ve partnered with Microba Life Sciences – a world leader in microbiome metagenomic analysis based in Australia. As Microba’s Clinical Solutions Manager, Dr. Ken McGrath combines his expertise in molecular genomics with the clinical application of this technology. Today, we speak with an industry-leading expert in microbiome research, Dr. Ken McGrath, who explains all things metagenomics, and what we’re now learning (and unlearning) about the gut microbiome. Today on The Lab Report: 3:15 Meet Dr. Ken McGrath 8:15 16s vs. whole genome sequencing metagenomics 16:20 Taxonomy and continually changing organism names 26:20 Microbes vs. Metabolites – total paradigm shift 32:00 Is Dysbiosis even a thing!? 33:45 Parasites, Yeast, and Metagenomics 39:20 Human genomics vs. bacterial genomics 45:30 Global microbiome differences 51:50 The Fireball(s) Additional Resources: Microba Genova's Microbiomix Profile Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

If you’ve never heard Dr. Jill Carnahan tell her personal story, you’re about to hear an inspiring and powerful episode. In the face of recurrent and unexpected illness, Dr. Jill never gave up. She continues to find resilience through functional medicine, science, and faith. With that, Dr. Jill uses all of the knowledge and wisdom she’s gained along the way to help patients all over the world. In today’s episode, Dr. Jill Carnahan inspires us all with her story of resilience. She also offers practical clinical advice that has helped her and many patients on their healing journeys. Today on The Lab Report: 2:40 Meet Dr. Jill Carnahan and hear her journey 10:30 Illness as a teacher, vulnerability, and the power of telling the story 16:30 Mold toxicity – signs and symptoms 19:05 Mold remediation and practical therapeutic steps 23:10 Recovery, long-term symptoms, and resilience 24:35 Inflammatory Bowel Disease – clinical pearls 31:30 Upcoming book and documentary! 36:20 The Fireball Additional Resources: JillCarnahan.com Unexpected: Finding Resilience through Functional Medicine, Science, and Faith Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

The Thanksgiving holiday is more than just family, friends, food, and football. It is an opportunity to be reminded of the importance of gratitude. Although being thankful seems like just a nice moral platitude, gratitude interventions are shown to have surprisingly important clinical implications for our health. On today’s episode, we talk Thanksgiving ‘fun facts,’ gratitude interventions, and strategies to combat holiday season stress and weight gain. Today on The Lab Report: 3:10 Fun facts about Thanksgiving 7:35 Gratitude interventions and health 11:15 Strategies to prevent holiday weight gain 14:30 Keto, Vegan, Carnivore, Omnivore holiday dinner menus 16:45 Kitchen Cook-cophany! Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Esther Blum is the industry expert when it comes to empowering women during the menopausal transition and beyond. As an integrative dietician, she’s helped thousands of women master menopause through nutrition, hormones, lifestyle, and self-advocacy. Her approach works and her client results speak for themselves. In today’s episode, Esther Blum offers her “Meno-Laws” - practical tips for peri- and menopausal women. We talk nutrition, hormone replacement, sleep, the right kind of exercise, and how to beat menopausal weight gain. Today on The Lab Report: 4:10 Meet Esther Blum and empowering women for self-advocacy 8:35 Meno-laws and nutrition strategies for menopause 12:05 Cortisol, carbs, keto, and hot flashes 14:25 Insomnia and sleep hygiene 16:00 Exercise, weight gain, and the Meno-pot belly 20:20 Bio-identical hormone replacement therapy 24:00 Herbal supplements for hormone support 25:15 The importance of testosterone for women 29:30 Gut health and menopause 31:00 The Fireball Additional Resources: estherblum.com See Ya Later, Ovulator! Cave Women Don't Get Fat The Eat, Drink, and Be Gorgeous Project Secrets of Gorgeous Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

As a colorectal surgeon, Dr. Brian Jerby has spent years dealing with the end-stages of GI diseases such as Crohn’s Disease and Ulcerative Colitis. He now focuses on getting to the root causes for preventing surgical intervention and mitigating long-term medication use. As a functional medicine certified practitioner, Dr. Jerby employs personalized tools to treat these patients such as nutrition, the microbiome, hormonal balance, lifestyle modification, and more – with excellent results. In today’s episode, we finally hit the topic of inflammatory bowel disease and the functional approach needed to treat these complex diseases. Dr. Jerby also discusses the critical role of stool testing in his practice and his excitement regarding the clinical implications of new metagenomic sequencing technology. Today on The Lab Report: 2:45 Meet Dr. Brian Jerby and hear his journey to functional medicine 8:10 Where do we start with Inflammatory Bowel Disease? 14:00 Is there hope for patients with IBD? 16:25 Diet and IBD 20:00 Patient success stories using stool profiles 24:55 Whole-genome sequencing in clinical practice 29:35 The latest on fecal transplants 35:55 Work with Dr. Brian Jerby and his practice 40:45 The Fireball Additional Resources: Legacy Health The Gut Connection Podcast GI Effects + Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.See omnystudio.com/listener for privacy information.

In functional and precision medicine, we know the importance of a healthy microbiome as it relates to overall health and wellness. Translating this into clinical practice is an art. Rachel Martin, a functional medicine nurse practitioner, specializes in gut health but through a different lens. Her approach to teaching and healing offers a fresh perspective with profound ramifications. What if we focus on stress and mental health first to optimize the microbiome for systemic health? In today’s episode Rachel Martin discusses her unique program “Go With Your Gut.” She talks about the importance of the gut-brain axis, building community, mitigating stress, and why this should be the first line of treatment for gut health. Today on The Lab Report: 3:40 Rachel Martin on her journey to functional medicine 8:10 Addressing stress and the gut-brain axis first 11:40 Systemic effects of the microbiome 14:30 Rachel’s “Go With Your Gut” program 17:45 Stress management strategies 21:10 Functional medicine testing in practice 25:40 Re-framing society’s expectations 30:00 The Fireball Additional Resources: Root + Ritual Functional Medicine GI Effects + Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Our bodies contain an inner clock that helps to regulate hormones and biochemistry. This clock is referred to as the circadian rhythm. The fine timing of this biological rhythm requires signaling from light. With the change in seasons, many of us feel the systemic effects of less daylight in various ways, one of which is altered mood. Seasonal Affective Disorder (SAD) is a type of depression that correlates with seasonal patterns. In today’s episode, we discuss the biochemistry of how light regulates the circadian rhythm, the etiologies of seasonal affective disorder, and various treatment strategies which have been used to improve symptoms. Today on The Lab Report: 2:15 The circadian rhythm and chronobiology – defining terms 5:00 Light signals and hormonal regulation of the biological clock 7:25 Health implications of seasonal change 9:30 Seasonal Affective Disorder 13:45 Vitamin D – What does it do? 18:10 Therapeutics and interventions 21:00 Question of the Day: Can seasonal affective disorder happen in the summer? Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

With the advent of the Human Microbiome Project and advancing technologies in whole-genome sequencing, the critical role of the gastrointestinal microbiome becomes clearer and clearer. We know the microbiome helps extract nutrients from the diet, creates important systemic metabolites, communicates with our skin and brain, and so much more. That being said, one such bacteria continues to stand out in the crowd– Akkermansia muciniphila. This bacterium, or lack thereof, may be a key player in obesity, metabolic disorders, inflammatory bowel disease, and ‘leaky gut’. In today’s episode, we explain the vital role of Akkermansia muciniphila. We discuss dietary strategies to boost levels and the new Akkermansia probiotic supplement! Today on The Lab Report: 2:30 The mucus layer of the GI tract 6:00 Mucin vs. mucus and altering the mucus layer 7:35 Akkermansia muciniphila 11:55 Logical Speculation – High levels good or bad? 14:10 Clinical implications of low levels of Akkermansia 16:40 Strategies to boost Akkermansia 18:05 Finally! A new Akkermansia probiotic! 19:05 Berberine is kinda awesome 20:00 Question of the Day How does Genova evaluate Akkermansia and mucin? Additional Resources: GI Effects + Microbiomix Pendulum Life (Use Promo Code GENOVA for 20% off your first month of a Pendulum membership!) Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Bacteria are everywhere in the environment. Although we understand there is a delicate balance of bacteria in our bodies which keep us healthy, many don’t grasp the complexity of how bacterial populations interact, adapt, and survive. They form structures called ‘biofilms’ which have become a hot topic in functional medicine as it relates to treating resistant or recurrent infections. In today’s episode, we dive into the topic of bacterial biofilms- when to suspect them and ways to treat them. Today on The Lab Report: 4:00 What are biofilms? 6:05 EPS, persister cells, and quorum sensing 8:40 Clinical importance and redeeming qualities? 11:35 Treating biofilms 13:20 Antimicrobial lipids 14:55 “What is it?” 18:50 Biofilm take-home points Additional Resources: GI Effects with Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

If you’ve seen the Netflix documentary “The Social Dilemma,” you’ll recognize today’s guest. Dr. Anna Lembke is an addiction specialist from Stanford University, a New York Times best-selling author, and was featured on that Netflix special. Addiction takes many forms – not only alcohol and illicit drugs, but also social media, exercise, shopping, and workaholism. But, where’s the line between habit and addiction? What can we do to reset our brain chemistry? In this episode, Dr. Lembke explains dopamine’s role in our brain’s reward system. We discuss addiction in its many forms, social media, and strategies to rewire dopamine pathways. Today on The Lab Report: 3:00 Anna Lembke explains dopamine and the reward system 6:05 Dopamine hits in today’s society 10:40 Moderation vs. Abstinence 13:30 Social media and children 15:00 Does society award addictive behavior? 18:45 Long term dopamine dysfunction and Parkinson’s disease 22:00 Parenting in the digital age 27:20 The Fireball Additional Resources: annalembke.com Dopamine Nation Drug Dealer, MD The Social Dilemma Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

The commensal bacteria in the gut microbiome are responsible for so many important functions. Their influence is far-reaching as it relates to overall health. Research shows us that the more diverse that community of bacteria is, the more beneficial it is to systemic health. But what does diversity mean and how do we measure it? There are many calculations used when it comes to diversity of the microbiome, and they can sometimes give differing information. It’s important to understand what’s being measured in order to clinically correlate the result. In today’s episode, we discuss the industry standard Shannon Diversity Index as measured on Genova’s brand new Microbiomix profile. Today on The Lab Report: 3:15 Better Know a Biomarker: Shannon Diversity Index 6:00 Evenness and Richness 7:30 Alpha vs. beta diversity 10:05 Who’s Claude Shannon? 13:00 Get Outta Here! 15:50 Simpson vs. Shannon Index 17:40 The numerical score 19:45 Improving the diversity score Additional Resources: GI Effects with Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

In the evolving landscape of microbiome research, we are beginning to see that our gut microbiome has more control over our health than we ever knew. Genova’s Microbiomix profile uses the newest technology of whole genome sequencing which adds another layer of understanding. We now see that the microbiome is one of our most important health indicators. We know that commensal bacteria produce many metabolites with far-reaching effects. But many of us forget that these bacteria also produce vitamins. In today’s episode, we discuss vitamin production in the GI tract, its contribution to systemic levels, and the interesting interplay between microbial communities. Today on The Lab Report: 4:30 Commensal bacteria make vitamins! 9:15 Colonic absorption, SIBO, and nutrient competition 11:35 Michael Writes Report Commentary 13:55 Microbial Vitamin K 16:05 How much do microbial vitamins contribute to DRI? 18:10 Which bacteria make what? 19:10 Microbiomix- Leading the Evolution of Microbiome Assessments 20:05 Question of the Day: Which ‘vitamer’ forms are made in the gut? Additional Resources: GI Effects with Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

The thyroid gland is responsible for regulating metabolism and is sometimes referred to as the ‘thermostat’ of our bodies. Even minor abnormalities in thyroid function can have far-reaching effects for every organ system. Thyroid diseases are prevalent worldwide and thyroid hormone replacement therapy is common. But many don’t realize that there are basic dietary nutrients that can have a huge impact and help optimize thyroid function. In today’s episode, we recap thyroid physiology and discuss how nutrition underpins thyroid hormone synthesis and metabolism. Today on The Lab Report: 4:00 Recap of basic thyroid gland physiology 7:45 Iodine and types of salt 10:45 Selenium, selenoproteins, and orbital rings 13:15 Everyone’s favorite cofactor - zinc 14:45 Iron and heme-dependent enzymes 16:10 Protein and amino acids 17:30 Question of the Day: Why does the NutrEval measure these nutrients in different matrices? Additional Resources: Comprehensive Thyroid Assessment NutrEval Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Mast Cell Activation Syndrome (MCAS) has become a hot topic in functional medicine. Mast cells are an integral part of the body’s immune system. They can be found in areas of exposure such as mucosal membranes, the lining of the GI tract, skin, and airways. Mast cells are responsible for storing important chemical mediators like histamine and others which help to instigate allergic responses. Mast cell disorders arise when there are too many mast cells, or they become hyper-reactive. That being said, these conditions are often misunderstood, and diagnoses are sometimes misused. In today’s episode, we focus on the role of mast cells and histamine in the immune response. We discuss the different mast cell activation disorders, how to diagnose them, and what you can do about it. Today on The Lab Report: 3:05 Mast Cell Activation Diseases 5:15 What is a mast cell? Why do we care? 7:05 Symptoms of histamine release 8:40 Histamine intolerance vs. MCAS 11:11 Foods: High Histamine or Low Histamine? 14:25 Non-food related histamine associations 15:30 Diagnosing and treating MCAS 18:00 Question of the Day What Genova profiles can help parse out histamine intolerance v. MCAS? Additional Resources: IgE Food Antibodies Profile IgE Inhalants - Allergy Profile IgE Mold - Allergy Profile Methylation Panel Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Dr. Dominic D’Agostino is a well-known leading researcher who studies nutritional strategies and metabolic-based therapies in neurological disorders, seizures, cancer, and metabolic wellness. He also happens to be a preeminent voice and proponent of the ketogenic diet. Ketosis is your body’s ability to burn fat for fuel when carbohydrates are not readily available – producing ketones. No longer thought of as a fad diet, it is actually a metabolic state that many adopt as a lifestyle given the emerging health benefits it confers. The metabolic effects of ketosis are vast and new insights are evolving rapidly. In today’s episode, we dive deep into biochemistry and metabolism with Dr. D’Agostino. He explains the latest research advancements in ketosis, differences between endogenous and exogenous ketones, and how continuous glucose monitoring factors into ketosis and metabolic health measures. Today on The Lab Report: 4:00 Welcome back, Dr. D’Agostino – why he chooses to study ketosis? 6:50 Surprising new clinical applications of ketogenic diets 12:40 Alzheimer’s disease, type 3 Diabetes, and ketones 17:00 Exogenous ketone esters/salts vs. endogenous ketones and metabolic effects 26:30 Is there a role for the ketogenic diet in ADD/ADHD? 29:15 Continuous glucose monitoring and ketosis 34:35 Glucose/ketone variation and the calculated index 43:00 Metabolic Health Summit 46:40 The Fireball Additional Resources: KetoNutrition Metabolic Health Summit Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Taylor Dukes is a board-certified family nurse practitioner with a very unique voice in functional medicine. Her practice is comprised of so many different kinds of patients. She specializes in family medicine, fertility, peri- and postnatal care, but also treats many high-performance athletes and celebrities. One of Taylor’s many passions is the role of the microbiome in systemic health – which applies to all patient populations. Her approach to optimizing gut health is comprehensive and her results speak for themselves. Today, Taylor is back on The Lab Report to chat about the role of the microbiome in health and disease, and she gives us her practical tips on optimizing it. Today on The Lab Report: 3:45 Taylor Dukes is back – and busier than ever! 8:30 The microbiome, sleep, and the gut-brain connection 11:15 Gut-skin axis – acne and eczema 13:15 Hormonal balance and the estrobolome 17:25 High performance athletes and the microbiome 20:22 Taylor’s approach to optimizing the gut 22:20 Peri- and postnatal nutrients 24:00 The Fireball Additional Resources: Taylor Dukes Wellness Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

If there’s one thing we’ve all come to appreciate during the COVID-19 pandemic, it is the importance of a healthy immune system. The immune system is a complex network of various cells, proteins, and organs that work together to help your body recognize and mitigate potential invaders, as well as recognize and protect itself. Metabolic health, proper nutrition, a healthy microbiome, and intact gut barrier are all important components necessary to support immune function. Dr. Tom Guilliams is a PhD researcher with a specialty in molecular immunology. He recently updated his seminal work “Supporting Immune Function.” Tom joins us on today’s show to discuss innate and adaptive immunity and outline the functional medicine approach to optimize immunity. Today on The Lab Report: 3:45 Tom Guilliams is back! 5:25 Conversations about immune health during the pandemic 9:15 Metabolic reserve 13:20 Literature during the COVID-19 pandemic 16:40 Immunosenescence 21:20 Functional approach to immune health 26:25 Nutrition and immunity 33:00 The role of the gut in immune health, innate vs. adaptive immunity, and vaccines 45:40 Emerging research on the effect of COVID on the microbiome 52:15 The Fireball Additional Resources: Point Institute Supporting Immune Function Lifestyle Matrix Resource Center Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. If you’re a patient looking for a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Summer brings tons of outdoor activities like hiking, camping, and backyard barbeques. It also brings bugs and insects. Likely you’ve encountered your fair share of bug bites, but one bite you don’t want to ignore is a tick bite! Because ticks are visually easy to miss, tick bites can go unnoticed too. Ticks can transmit organisms into your systemic circulation resulting in acute and chronic symptoms. Not all tick bites cause illness, but when they do it can be serious. In this episode, we touch on some common tick-borne illnesses, what symptoms to look for, and how to treat them. Today on The Lab Report: 2:45 Ticks are gross 6:15 Rocky Mountain Spotted Fever 8:45 Babesiosis 11:30 Lyme disease and conspiracy theories? 13:10 Deer ticks, rashes, and spirochetes 14:20 Chronic Lyme disease controversies 16:00 Nuances in Lyme Disease testing 18:00 Pathophysiology and treatment of chronic Lyme Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Many of us start the day with a hot cup of coffee. It’s not only a delicious beverage, but coffee is also part of our collective social fabric. Some drink it mainly for the caffeine and stimulating effect without realizing some of the important health benefits to coffee. However, like all things, moderation is the key. Too much caffeine leaves many people feeling jittery and anxious and at times, this can be dangerous. But coffee is more than just caffeine. Other compounds within it have important influences on our health. In today’s episode, we discuss the constituents of coffee and coffee beans and the mechanisms by which they affect health and disease. Today on The Lab Report: 2:40 The basics of coffee 5:45 Caffeine – the good, the bad, and the ugly 11:30 Diterpenes (kahweol and cafestol) 14:00 Chlorogenic acids and antioxidants 14:55 Micronutrients, adding cream and sugar 17:00 Health benefits and risks – what does the literature say? 23:40 Question of the Day How does caffeine affect cortisol testing? Additional Resources: Adrenocortex Stress Profile Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Of all the herbal and homeopathic natural therapies available, Arnica has become the most recognized in popular culture and the conventional medicine landscape. Many swear by its ability to reduce swelling, bruising, and inflammation. It can be found in over-the-counter gels, creams, and sometimes tinctures. Literature and outcome studies using Arnica cream are sparse, yet anecdotally there have been some interesting results. So, does it really work? And if so, how? In today’s episode, we discuss the herb Arnica and its medicinal constituents. We break down the proposed mechanisms of action, benefits and potential dangers, and even touch on homeopathic dilutions. Today on The Lab Report: 4:00 Introducing the Arnica plant 6:15 Medicinal plant constituents and physiologic effects 9:15 Preparations – poultices, tinctures, and cream/gel 11:15 Break it down – Homeopathy and dilutions 15:50 Toxicities and dangers of mis-using Arnica 19:35 What’s in a name? Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

In general, we often think about the commensal bacteria as being beneficial to your health. Did you know that the bacteria in the gut microbiome can also contribute to systemic inflammation and disease? There is molecule called lipopolysaccharide (LPS) within the outer membrane of all gram-negative bacteria. LPS can be readily taken up into circulation where it acts as an inflammatory trigger (endotoxin). But not all LPS can trigger the immune system. Only LPS molecules with a structure containing at least six acyl groups are large enough to stimulate cytokine release – hexa-acylated LPS. On today’s episode, we discuss the LPS molecule, and more specifically hexa-LPS. What is it, how does it cause a problem, and more importantly, what can we do to prevent it from causing inflammation? Today on The Lab Report: 2:30 Gram-negative vs gram-positive bacteria 4:40 Lipopolysaccharide (LPS) and systemic endotoxemia 7:05 Hexa-acylated LPS vs. LPS 9:55 Protecting the gut mucosal barrier 10:40 The role of dietary fat 12:15 Logical Speculation: Dietary saturated fats are not all created equally 17:15 Question of the Day? How do we measure LPS? Additional Resources: Intestinal Permeability Assessment GI Effects Stool Profile   Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.  See omnystudio.com/listener for privacy information.

Many patients are not able to tolerate milk and dairy products due to GI symptoms such as bloating or diarrhea. In functional medicine, an elimination diet or food antibody testing can help uncover if the casein in cow’s milk might be at the root of these symptoms. Patients often turn to milk alternatives such as plant and nut ‘milk’ to avoid the difficulties with cow’s milk. However, research is showing that it may be a specific type of casein that is causing the problem in milk and there is a debate on the health risks of types of casein: A1 vs. A2. Today we break down the controversy regarding A1 versus A2 milk and we discuss the pros and cons of various types of milk. Today on The Lab Report: 2:10 Not all white liquid is milk!!! 4:15 Milk constituents 7:15 Casein – A1 vs A2 beta-casein and BCM7 9:10 BCM7 and systemic illnesses 10:55 Which animals give us A1 or A2 milk? 13:25 Controversies in literature – other factors 14:30 Game alert: “What is it?” 17:00 Benefits and concerns with plant and nut ‘milks’ Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.      See omnystudio.com/listener for privacy information.

Foods come in and out of favor all the time. Eggs are good for you… no wait, they are bad… nope, good again – let’s not even discuss butter! There are many disease correlations related to specific foods and literature continues to evolve. One such focus is on red meat and its correlation to cardiovascular disease.  But why? Is all red meat bad? Can you eat red meat and not increase heart disease risk? What about it should cause concern? Interestingly, the answer lies in the microbiome’s ability to metabolize the carnitine in red meat into a metabolite called trimethylamine (TMA). What happens from there is the key!  But be warned, there is more to TMA than red meat and carnitine. Today we discuss TMA and how it becomes a cardiovascular risk factor (TMAO). We tell you about TMA’s many sources - besides red meat - and why you should care. Today on The Lab Report: 2:10 Food controversies 3:50 Break it Down: Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) 6:40 TMAO, carnitine, and choline 10:00 Wait, which foods are actually the problem? 13:50 Red meat, TMAO, and cardiovascular risk 18:40 Dietary microbiome changes 20:05 Question of the Day: Which Genova profiles can help? Additional Resources: NutrEval Cardio Check Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Many clinicians in functional medicine advocate diet and lifestyle‐first approaches to optimizing health. Though in spite of best efforts there is often still a need for nutraceutical supplements - and targeted supplementation can be a game-changer in some cases. However, the issue of compliance and ‘pill fatigue' becomes a real challenge when patients are overwhelmed with 5-10 supplements at once. Justin DeTurris helps to solve this problem. He co-founded Personalized Nutrients which allows practitioners to consolidate multiple nutraceutical products into one homogenous formulation giving them absolute control in individualizing therapies for their patients. Today, we talk to Justin DeTurris about standards within the nutraceutical supplement industry, the challenge of compliance and pill fatigue, and what you can do about it.   Today on The Lab Report: 3:50 Meet Justin DeTurris and Personalized Nutrients 8:55 Questions you should be asking about standards and raw materials 14:30 Fillers, purity, and supply chain challenges 20:25 ‘Pill Fatigue’ and patient compliance 28:50 Personalized Nutrients’ -Online Formulator 31:45 The Fireball Additional Resources: Freedom to Formulate Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.    See omnystudio.com/listener for privacy information.

Dr. Kyle Gillett has a unique approach to patient care using his six pillars of health: exercise, diet, sleep, stress, sunshine, and spirit. His expertise and teaching style are highly regarded in the integrative and functional medicine industry.  Dr. Gillet continues to make a name for himself in national media by forwarding the concepts of personalized medicine. Although he is an expert in many fields, in this episode we focus on male hormones.     Listen in as we discuss Dr. Gillett’s pillars of health and how he uses them in practice. We also hear about his approach to balancing male hormones, the role of testing, and when to use testosterone replacement therapy (TRT).  Today on The Lab Report: 3:20 Kyle Gillett on family medicine and obesity medicine 8:00 The 6 Pillars of Health 10:45 The overall approach to male hormonal balance 12:20 When to reach for Testosterone Replacement Therapy (TRT) 19:35 Aromatase inhibitors and estrogen 22:05 TRT in females 24:35 The roll of the microbiome in hormonal health 28:40 Important nutrients for hormones 30:30 The Fireball         Additional Resources: Gillett Health Gillett Health on YouTube Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.  See omnystudio.com/listener for privacy information.

Many functional and integrative clinicians practice medicine through the construct of finding the root cause of chronic complaints and disease management. What if there was a framework in place to help clinicians navigate a focus on health optimization? Dr. Scott Sherr has the answer. Along with Dr. Ted Achacoso, he founded Health Optimization Medicine and Practice (HOMe/HOPe), a non-profit education company offering CME accredited certification and ongoing educational modules to help clinicians detect and correct root causes of health – not disease. Today we discuss this paradigm shift with Dr. Scott Sherr and learn about the HOMe/HOPe philosophy. We also dive into hyperbaric oxygen therapy, one of Dr. Scott’s many specialties. Today on The Lab Report: 3:20 Meet Dr. Scott Sherr and hear about his path to HOMe 12:45 Competing paradigms and creating a new framework 16:50 The HOMe/HOPe approach – ‘saluneotinoholobiontology’ 22:35 Education and Practice Modules 26:20 Hyperbaric oxygen therapy 40:00 Lab testing in the HOMe/HOPe framework 49:25 The Fireball Additional Resources: HOMe/HOPe Dr. Scott Sherr - HBOT Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.  See omnystudio.com/listener for privacy information.

Many clinicians who are new to functional medicine have a difficult time translating these concepts into their clinical practices. That transition from conventional to personalized medicine can feel overwhelming - but the Lifestyle Matrix Resource Center has the answers! Josiah Bartz oversees this company and is dedicated to helping healthcare professionals implement lifestyle-based therapies in their practices. Today, we meet Josiah Bartz to discuss the challenges faced by clinicians and the numerous, innovative ways Lifestyle Matrix Resource Center can help!   Today on The Lab Report: 3:55 Josiah Bartz - 20 years of watching functional medicine evolve 15:30 What is the Lifestyle Matrix Resource Center? 24:20 Practical tools to help clinicians 31:40 New membership-level resources 39:45 The Fireball Additional Resources: Lifestyle Matrix Resource Center Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

In functional medicine, we dig deeper to find the root cause of illness and strive to find personalized strategies to optimize health. However, sometimes even that falls short. Dr. Jade Teta has spent over 20 years treating patients, teaching, and writing about health and wellness. He blends biochemistry and philosophy in a way that inspires us to find our true purpose. In so doing, we can all learn how to become “Next Level Human.” In today’s episode, we discuss Dr. Teta’s unique approach to health, diet, metabolism – and philosophy!   Today on The Lab Report: 3:25 Meet Dr. Jade Teta and learn his definition of a Next Level Human 9:25 Integrative endocrinology – a holistic approach to metabolism 12:55 The “Do What Works for You” Diet and the language of metabolism 20:15 Translating diet, lifestyle, and metabolism to patients 24:20 Wearable devices 27:00 ‘Meathead Philosopher’ 31:05 The Lack of Purpose pandemic  39:30 Teta’s online teaching programs 42:50 The Fireball    Additional Resources: jadeteta.com Next Level Human Podcast Human 365 Next Level Tribe The Metabolic Effect Diet   Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.  See omnystudio.com/listener for privacy information.