The Immunology Podcast

Guest: Dr. Nicole Quinn is the Director of Brand and Scientific Communications at STEMCELL Technologies, where as part of her role, she develops and oversees programs that help scientists keep current with the latest scientific advances and innovations in their field. In this episode, she discusses the upcoming second season of the Lab Coats & Life Podcast, which aims to help scientists thrive by keeping listeners informed about useful soft skills and relevant trends in the scientific community. She talks about her role as a co-host, what she’s learned about podcasting, key takeaways from conversations about science mentorship, and what to expect in Season 2. (38:33) Featured Products and Resources: Late-breaking abstract submission for IMMUNOLOGY2025 closes on January 21st. Submit your abstract for IUIS 2025 by January 30th. The Immunology Science Round Up The Aging Mouse Immune System – Researchers delineated the landscape of cell-type-specific transcriptomic changes associated with normal aging in mouse brains. (3:00) Neoepitopes for Adoptive T Cell Therapy – Conventional T cell therapy can benefit from targeting tryptophan to phenylalanine neoepitopes. (9:16) Gut Microbiota and Lung Disease – A commensal protozoan tunes pulmonary immunity via a gut-operated lung immune network. (20:25) Lymphocyte Migration – Inflamed lymph nodes switch CCR7 ligand mediating lymphocyte recruitment from CCL21 to CCL19. (28:35) Image courtesy of Dr. Nicole Quinn Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Gail Bishop is a Professor of Microbiology and Immunology at the University of Iowa, where her lab studies the molecular mechanisms underlying lymphocyte activation and tolerance. She talks about TRAF signaling, the NFκB pathway, and effects on B and T lymphocytes. She also discusses her role as Editor-in-Chief of The Journal of Immunology. Featured Products and Resources: Registration is open for IMMUNOLOGY2025! The 19th International Congress of Immunology to be held in Vienna from August 17-22, 2025! The Immunology Science Round Up Pyroptotic Cell Corpses – Cells assemble filopodia before cell rupture to serve as a posthumous mark for a cell that has died by gasdermin-induced pyroptosis. Engineering Synthetic T Cell Receptors – T-Switch identifies therapeutic TCR variants with enhanced potency and specificity. Macrophages in Muscle – Macrophages in muscle spindles express the machinery for synthesizing and releasing glutamate. Synthetic Suppressor T Cells – Researchers engineered human T cells to make a synthetic receptor that recognized overactive T cells. Image courtesy of Dr. Gail Bishop Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Lili Yang is a Professor of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles. Her research centers on deciphering the molecular mechanisms regulating anti-cancer immune responses, exploiting knowledge to develop novel immunotherapies for treating cancer, and translating these new cancer immunotherapies from bench to bedside. She talks about engineering off-the-shelf immunotherapies to fight cancer and generating CAR-NKT cells from hematopoietic stem and progenitor cells. She also discusses the role of serotonin and how SSRIs can affect cancer therapy efficacy. Featured Products and Resources: Registration for IMMUNOLOGY2025 opens December 10! The 19th International Congress of Immunology to be held in Vienna from August 17-22, 2025! The Immunology Science Round Up Preventing Apoptosis – Apoptosis inhibition by NLRP3 activators is due to their effects on mitochondria rather than inflammasome activation. SARS-CoV-2 Spike Proteins in the Brain – SARS-CoV-2 spike protein persists in the skull-meninges-brain axis in COVID-19 patients. CAR T to Protect Transplanted Beta Cells – hPSCs and Tregs can be co-engineered to protect hPSC-derived cells from immune rejection upon transplantation. Endogenous Retrovirus Antibodies – An antibody produced by endogenous retrovirus-reactive B cells recognized glycans of a broad range of enveloped viruses. Image courtesy of Dr. Lili Yang Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Rahul Roychoudhuri is a Professor of Cancer Immunology at the University of Cambridge (Department of Pathology) and Director (Non-Clinical) of the CRUK Cambridge Centre Training Programme. His lab studies immunoregulatory mechanisms in inflammation and cancer. He talks about enhancing cell therapy with new payloads and targeting cancer cells during metastasis. Featured Products and Resources: IMMUNOLOGY2025 is happening May 3-7 in Honolulu, Hawaii! The 19th International Congress of Immunology is being held August 17-22 in Vienna, Austria! The Immunology Science Round Up Colonizing the Human Microbiome – Researchers identified a phylogenetically distinct group of microbiome-associated, viroid-like RNAs. Immune Privilege of the Central Nervous System – Regulatory self-peptides bind to MCH II molecules at the central nervous system border. Heart Attacks and Sleep – Monocytes are recruited to the brain after myocardial infarction to augment sleep and promote healing. The Circadian Rhythm in Immune Homeostasis – IL-17-producing γδ T cells rely on the molecular clock to maintain adipose tissue homeostasis. Image courtesy of Dr. Rahul Roychoudhuri Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Pascal Meier is a Professor and Group Leader at the Institute of Cancer Research in London, England. His group investigates the complex relationship between cell death, immunity, and tumorigenesis. Particularly, they are focused on the role of cell death and inflammation in adaptation to tissue stress, treatment resistance, and tumour surveillance. Featured Products and Resources: IMMUNOLOGY2025 is taking place May 3-7 in Honolulu. Submit your abstract now! Switch to a more efficient way to isolate cells with EasySep The Immunology Science Round Up: New Potential for Cancer Immunotherapy – Researchers have identified a new type of immune cell called stem-like CD4 T cells that play an important role in anti-tumor immunity. An Improved Treg Therapy – Human OX40 ligand-specific CAR-Tregs may be a potent cellular therapy to control allo- and autoimmune diseases. Chronic Inflammation Worsens Heart Failure – Blocking the molecular signals between inflammation-causing immune cells and fibroblasts can prevent fibrosis. Programmable Bacteria – Scientists have engineered a strain of bacteria to express cytokine IFN-γ within the tumor core. Image courtesy of Dr. Pascal Meier Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Marcelo Hill is the Head of the Laboratory of Immunoregulation and Inflammation at the Institut Pasteur de Montevideo. He is also the Founder and Chief Scientific Officer of ARDAN ImmunoPharma. His research focuses on immune regulation in cancer, and how T cells respond to immunotherapy in melanoma. He talks about improving immunotherapy efficacy by activating the inflammasome, and how he is pushing this research towards the clinic by collaborating with industry and creating a spin-off company. He is then joined by Drs. Marion Brunck and María Julia Lamberti, who discuss the upcoming meeting of the Latin American and Caribbean Association of Immunology, taking place November 4-8 in Buenos Aires. They discuss the challenges and opportunities in the Latin American immunology community, and how this conference aims to promote collaborations and empower early-career researchers. Featured Products and Resources: IMMUNOLOGY2025 is taking place May 3-7 in Honolulu. Submit your abstract now! The 19th International Congress of Immunology will be held in Vienna from August 17-22, 2025. The Immunology Round Up Staphylococcus aureus Biofilm – Scientists studied tissue microenvironments in models of S. aureus craniotomy and prosthetic joint infections. T Helper Cell Differentiation – Researchers found that RAMP3 has a cell-intrinsic role in TH1 cell fate determination. Probiotic Immunotherapy – Researchers used E. coli to deliver neoepitopes that drive T cell-mediated anticancer immunity. Microglia in Alzheimer’s Pathology – APOE internalization is regulated by cholesterol metabolism in microglia. Image courtesy of Dr. Marcelo Hill Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: Dr. JoAnne Flynn is a Professor of Microbiology and Molecular Genetics at the University of Pittsburgh and Dr. Stephen Hedrick is Chancellor’s Associates Chair VII Distinguished Professor Emeritus at the University of California, San Diego. They talk about the American Association of Immunologists’ Immunology Explained campaign, which aims to explain the science of the immune system to the general public. They also discuss their efforts to educate legislators about the value of immunology research and promote childhood vaccination. Featured Products and Resources: Submit your abstract for IMMUNOLOGY2025! Read interviews from immunologists. The Immunology Science Round Up Postnatal T Cell Development – Spatial multiomics show sex differences in early postnatal T cell development. Organ-Specific Tissue Residency – Retinoic acid is a fundamental component of the host-environment interaction that directs immunosurveillance in tissues. A Pan-Sarbecovirus Antibody – Scientists identified an antibody that competes with ACE2 and neutralizes several SARS-CoV-2 variants. NK Cells in RSV – An altered NK cell immunophenotype is associated with severe RSV disease in young children. Images courtesy of Drs. JoAnne Flynn and Stephen Hedrick Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Theresa Alenghat is a Professor in the Immunobiology Division and the Margaret K. Hostetter Chair at Cincinnati Children’s Hospital Medical Center, University of Cincinnati. Her lab investigates mechanisms underlying the host-microbiota relationship, and how this regulation affects intestinal immunity and inflammatory bowel disease. She discusses how butyrate affects tuft cells in the intestine. Featured Products and Resources: Submit your abstract for IMMUNOLOGY2025! Add Intestinal Organoids to Your Research with IntestiCult. The Immunology Round Up Ancient Cheese – Researchers retrieved DNA from ancient kefir cheese to study how human-microbial interactions contribute to the adaptation of domesticated lactobacilli. Mitochondrial Movement – Mitochondrial transfer augments CD8+ T cell mitochondria mass and metabolic fitness. CAR T Atlas – Scientists generated a single-cell atlas of pre-infusion CAR T cells and found that elevated type 2 functionality is associated with remission of leukemia. NAD+ Reconstitution – A unique immune evasion strategy allows viruses to rebuild molecules depleted by the host’s defense system. Image courtesy of Dr. Theresa Alenghat Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Roslyn Kemp is a Professor of Immunology at the University of Otago. Her research focuses on T cells as mediators of anti-tumor immunity and inflammation. She discusses using organoids to model inflammatory bowel disease and collecting immune cell signatures in cancer. She also talks about writing a book to demystify science research and careers. Featured Products and Resources: Abstract submission for IMMUNOLOGY2025 opens on October 1. Register now! Support the culture of human T cells and enhance your cell therapy development by using high-performance, cGMP-manufactured ImmunoCult-XF medium. The Immunology Science Round Up Extending Responses after HIV Treatment – IL-10 and PD-1 blockade controlled viral rebound of SIV in rhesus macaques during analytical treatment interruption. Autoreactive T Cells in Lupus – Neoself-antigen presentation by MHC-II plays a crucial role in the pathogenesis of systemic lupus erythematosus. Bison Bile Salt Hydrolase – Researchers determined the molecular structure of a bile salt hydrolase from the bison microbiome. How Gender-Affirming Hormone Therapy Affects Immunity – Testosterone in trans men alters a cross-regulation axis involving IFN-I and TNF. Image courtesy of Dr. Roslyn Kemp Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Wayne Juang is a Field Application Scientist, Immunology at STEMCELL Technologies. In his current role, he works with researchers to help optimize and troubleshoot their experiments. He discusses his path to industry and his motivation to pursue an MBA. Featured Products and Resources: Register now for IMMUNOLOGY2025, the world’s leading annual all-immunology meeting! Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center. The Immunology Round Up TNF Mutations and Tuberculosis – Two relatives who lack working copies of the TNF gene experienced recurrent bouts of tuberculosis, but are unaffected by other pathogens. Fibrin and Clotting in COVID-19 – Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection. Salt in Tumors – Sodium chloride in enhances the activation state and effector functions of human CD8+ T cells. Fatal Respiratory Infections – Researchers identified oleoyl-ACP hydrolase as an early driver of several severe respiratory diseases. Image courtesy of STEMCELL Technologies Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Kipp Weiskopf is a Valhalla Fellow at the Whitehead Institute. His research focuses on unlocking the therapeutic potential of macrophages for the benefit of cancer patients. He talks about the role of macrophages in the tumor environment and how targeting the CD47/SIRPα axis can induce phagocytosis of cancer cells. He also discusses starting spin-off companies to advance cancer therapies. Featured Products and Resources: Request your free copy of the ‘Human Immune Cytokines’ Wallchart The STEMdiff Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells. The Immunology Round Up Organoids with an Immune Compartment – Researchers generated human intestinal immuno-organoids to investigate intestinal inflammation triggered by cancer-targeting biologics in patients. Gene Repression in Tregs – The transcription factor Ikaros binds to Foxp3 to inhibit the expression of target genes in Tregs. γδ T-Cell Antigen Receptor Structure – Scientists used cryo-electron microscopy to determine the structure of of the T-cell receptor found on the surface of γδ T cells. Autoimmune Organ Damage – Tissue-resident NKp46+ innate lymphoid cells are crucial signal amplifiers of disease-associated macrophage expansion and epithelial cell injury in lupus nephritis. Image courtesy of Dr. Kipp Weiskopf Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Adrian Erlebacher is a Professor in the Department of Laboratory Medicine at the University of California, San Francisco. His lab studies how the developmental properties of a tissue influence its ability to mount a successful immune response. He talks about immune tolerance in pregnancy and how the maternal–fetal interface affects pregnancy outcomes. Featured Products and Resources: Free wallchart: human immune cytokines. Generate fallopian tube organoids with GyneCult. The Immunology Science Round Up Immune Cells in the Skull – The glioblastoma-linked immune-cell niche in the human skull provides an unanticipated resource and concept of acute tumor reactivity in the proximal bone marrow. Nasal Vaccine Reactions – Nasal vaccination induces B cell expansion in the subepithelial dome of nasal-associated lymphoid tissues. Airway Microbiota Across the Lifespan – Lifestyle factors are related to oral microbiota and environment is related to nasopharyngeal microbiota. Tregs in the Gut – Researchers used a chemogenetic screen to reveal functional neuroimmune interactions in the gut. Image courtesy of Dr. Adrian Erlebacher Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Jeffrey Rathmell is the Cornelius Vanderbilt Professor of Immunobiology at the Vanderbilt Center for Immunobiology. His research focuses on T cell metabolism in cancer. He talks about what T cells use for fuel and his work on fatty acid synthesis. He also discusses the ‘obesity paradox’ in cancer immunotherapy and his favorite parts of being a scientist and professor. Featured Products and Resources: The Immunology Podcast has been nominated for a People’s Choice Podcast Award! Differentiate human monocytes into macrophages with STEMCELL’s ImmunoCult-XF Macrophage Medium. The Immunology Round Up A Humanized Mouse Model – A new humanized mouse mounts specific and mature antibody and autoantibody responses. IL-11 Signaling in Aging – Inhibiting IL-11 extends the healthspan and lifespan of mice. Sphinganine Synthesis in Macrophages – Sphinganine biosynthesis is a checkpoint for macrophage pattern recognition in mouse models of sepsis and melanoma. Brain-Muscle Signaling – Researchers identified a brain-to-muscle signaling axis in Drosophila that regulates muscle performance. Image courtesy of Dr. Jeffrey Rathmell Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Shana Kelley is the President of the Chan Zuckerberg Biohub Chicago and the Neena B. Schwartz Professor of Chemistry and Biomedical Engineering at Northwestern University. The Kelley research group works in a variety of areas spanning bio analytical technology development and has pioneered new methods for tracking molecular and cellular analytes with unprecedented sensitivity. She talks about developing DNA-based reagentless biosensors and commercializing new technologies. Featured Products and Resources: The Immunology Podcast has been nominated for a People’s Choice Podcast Award! Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies. The Immunology Science Round Up Tuberculosis Target Structure – Cryogenic electron microscopy structures of Mycobacterium tuberculosis ATP synthase sheds light on drug binding. Toll-Like Receptor Signaling – Researchers engineered macrophages to delineate TLR pathway activities. Onco-Fetal Immune Tolerance – Scientists cross-analyzed single-cell RNA sequencing data from human cancer types and the maternal-fetal interface to identify an onco-fetal immune tolerance checkpoint. Tau Immunotherapy – Scientists loaded tau antibodies into micelles and administered them intranasally in mice. Image courtesy of Dr. Shana Kelley Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Susan Kaech is a Professor and Director of the NOMIS Center for Immunobiology and Microbial Pathogenesis at the Salk Institute. Her lab aims to understand how memory T cells are produced during infection and vaccination, how they function, and why they can fail to induce long-term immunity, particularly during chronic disease or cancer. In this episode, she talks about her research on T cell exhaustion and neuroimmunology, as well as her path from genetics to immunology. Featured Products and Resources: Keep current with the latest in human immunology news. Achieve robust T cell expansion with ImmunoCult-XF. The Immunology Round Up Glycan Breakdown and Bacterial Function – Researchers used a large-scale screen to identify enzyme systems that represent an underappreciated mode of glycan degradation. Cancer Risk after CAR T Therapy – Only a small percentage of patients who receive CAR T therapies develop secondary cancers, and most are not directly linked to CAR T treatment. CD8+ T Cells in Hepatitis B – Hepatocellular priming induces key co-signaling receptors in dysfunctional CD8+ T cells. T Cell Aging – T cell epigenetic clocks measure replicative history and can continue to accumulate well-beyond organismal lifespan. Image courtesy of Dr. Susan Kaech Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Priya Devarajan is an Assistant Professor at Stony Brook University. Her work focuses on immune memory and respiratory immunology. She talks about how aging affects the immune system and strategies to promote immune responses in the nose and lungs. She also discusses improving influenza vaccine responses and her experience interviewing for faculty positions. Featured Products and Resources: Keep current with the latest in pulmonary cell news. Grow Functional Airway Organoids with PneumaCult. The Immunology Science Round Up γδ T Cells Across the Life Span – Antigenic exposures over childhood drive the functional evolution and tissue compartmentalization of γδ T cells. Glucose Restriction and Viral Response – Glucose restriction is a physiological mechanism to bring the body into a heightened state of responsiveness to viral pathogens. A Gene Desert Implicated in Autoimmunity – Researchers used functional genomics to identify a central regulator of human inflammatory macrophages. Stripy T Cells – Some T cells within a population have nuclear envelope invaginations that concentrate cellular organelles. Image courtesy of Dr. Priya Devarajan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Erika Moore is an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland, where her lab is committed to engineering biomaterial models that harness the regenerative potential of the immune system. She talks about building biomaterials, rejuvenating macrophages, and treating lupus. She also discusses using the right cells in research and promoting financial literacy to make science careers more accessible. Featured Products and Resources: Explore scientific resources for your immunology research. Differentiate human monocytes into macrophages with ImmunoCult-SF Macrophage Medium. The Immunology Science Round Up Heart Failure – Bone marrow can carry an innate immune memory of cardiac stress that may exacerbate heart failure. Epstein Barr and B Cells – Virus-orchestrated NAD biosynthesis is a druggable metabolic vulnerability of Epstein Barr virus-driven B cell transformations. Microbiome Modulation in Pregnancy – Bacterial conversion of corticoids into progestins may affect host physiology, particularly in the context of pregnancy. The Circadian Rhythm and Tumor Immunosuppression – Circadian gating of tumor immunosuppression informs the timing and efficacy of immune checkpoint inhibitors. Image courtesy of Dr. Erika Moore Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Kellen Cavagnero is a Postdoctoral Fellow at the University of California, San Diego. His PhD work focused on how fibroblasts — a cell type thought to be immunologically inert — contribute to chronic inflammatory conditions and defense against pathogens. He talks about staph infections, antimicrobial resistance, and the types and roles of fibroblasts. He also discusses his work in science communication, including his podcast, Inflammatory Content. Featured Products and Resources: Read more interviews with immunologists in STEMCELL’s ‘Immunology Profiles’ series. Scale up your cell isolation with the Easy 250 EasySep Magnet. The Immunology Science Round Up Malaria Immunity – Scientists leveraged a human malaria infection study to investigate functional correlates of immunity. CAR T Therapy for HIV – Anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies resulted in significant suppression of viral rebound in HIV patients. Immunogenic Cell Death – Researchers generated a small-molecule proteolysis-targeting chimera that selectively degraded human and murine RIPK1. Origins of Autoimmunity – NUDCD3 is required for healthy T and B cell development in humans. Image courtesy of Dr. Kellen Cavagnero Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists, in Chicago. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending and the most memorable research presented. Featured Products and Resources: Prepare for your next conference. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: Dr. Jo Viney is the CEO, President, & Co-Founder and Dr. Ryan Peckner is the Director of Machine Learning & Computational Biology at Seismic Therapeutic. In this special episode recorded in front of a live audience at IMMUNOLOGY2024 in Chicago, they discuss artificial intelligence and its applications in drug discovery and protein engineering. They talk about its limitations, its role in clinical trials, and how scientists can leverage these tools to advance their careers. Featured Products and Resources: Catch up on daily summaries of IMMUNOLOGY2024 sessions. Prepare for your next conference! Images courtesy of Drs. Jo Viney and Ryan Peckner Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of five special episodes from the meeting, where Brenda and Jason talk about sessions including the dysfunction of exhaustive T cells enforced by MCT11-mediated lactate metabolism and extrafollicular differentiated B cells, presented by former podcast guest Dr. Frances Lund. Featured Products and Resources: Prepare for your next conference Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting, where Brenda and Jason highlight discussions on tumor-infiltrating lymphocyte therapy, chaired by former podcast guest Dr. Kristin Anderson, as well as fueling T cell fate decision during infection with an initial focus on immunometabolism. Featured Products and Resources: Download a free ebook on cell separation! Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of five special episodes from the meeting. Brenda and Jason spotlight discussions on cellular responses of microbial and parasitic infection and the immunology of pregnancy with a focus on glycan regulation of fetomaternal tolerance. Featured Products and Resources: Explore free immunology wallcharts! Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting. Brenda and Jason discuss highlights from sessions including microbial and environmental influences on the gut and recent breakthroughs in emerging therapeutic strategies for chronic inflammatory and fibrotic diseases. Featured Products and Resources: Stay up-to-date with the latest in immune regulation news. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting, in which Jason and Brenda highlight sessions on innate and innate-like cells and transplant immunology. Discussions include the role of hypothermia in protecting ventilator-induced lung damage and Siglec-E knockout in transplant rejection. Featured Products and Resources: Stay up-to-date with the latest in human immunology news. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Caleb Lareau is an Assistant Professor at Memorial Sloan Kettering Cancer Center. His lab aims to understand how cells in our bodies adapt, expand, and evolve during the course of our lives, particularly in the immune system. He talks about cross-training in bioinformatics and immunology, and herpesvirus reactivation in CAR T cells. Featured Products and Resources: Check out the program for IMMUNOLOGY2024, happening May 3-7 in Chicago! Attend a live show on artificial intelligence in immunology. The Immunology Round Up Blocking Lung Injury in Influenza – Scientists developed an inhibitor to block necroptosis in severe influenza infections. Germinal Center Memory B Cells – IL-4 signaling can regulate memory B cell selection. Intestinal Barrier Defence – Citrobacter rodentium targets a subset of absorptive intestinal epithelial cells in the mid–distal colon, which stimulate T cells to produce sustained IL-22 signals to mitigate further spread of the pathogen. Fast-Acting Glucocorticoids – The anti-inflammatory properties of glucocorticoids involve reprogramming of the mitochondrial metabolism of macrophages. Image courtesy of Dr. Caleb Lareau Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Mitchell Kronenberg is a Professor and President Emeritus at La Jolla Institute for Immunology. His lab studies how innate-like T cells adapt to different tissue environments. He talks about his work on MAIT cells and mucosal immunology, as well as his time leading the Institute. Featured Products and Resources: Check out the program for IMMUNOLOGY2024, taking place May 3-7 in Chicago! Get updates about new mentorship content from Lab Coats & Life. The Immunology Science Round Up Immune System Regeneration – Depleting myeloid-biased HSCs in aged mice restores features of a more youthful immune system. Gasdermin in Pyroptosis – Gasdermin D N-terminal domain palmitoylation controls gasdermin membrane localization and activation. Antibody-Drug Conjugates for Cancer – Scientists developed an antibody–drug conjugate that could kill TRBC1+ cancer cells in vitro and cure human T cell cancers in mouse models. Hemorrhagic Fever Cell Receptors – The low density lipoprotein receptor is critical for the Crimean–Congo hemorrhagic fever virus to enter host cells. Image courtesy of Dr. Mitchell Kronenberg Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Scott Canna is an Associate Professor of Pediatrics (Rheumatology), and Attending Physician, Pediatric Rheumatology and Immune Dysregulation at the Children’s Hospital of Philadelphia. His group studies the mechanisms of immune dysregulation. He talks about auto- and hyperinflammatory diseases and the role of IL-18. He also discusses hemophagocytic lymphohistiocytosis and adapting therapies for children. Featured Products and Resources: Check out the program for IMMUNOLOGY2024! Listen to the new Lab Coats & Life Podcast, featuring Brenda and Jason as co-hosts! The Immunology Science Round Up Microbial Metabolites in Infectious Diseases – Dietary tryptophan protects against gastrointestinal infection by activating the neurotransmitter receptor dopamine receptor D2. T Cell Tolerance – Scientists used neural networks and hybrid mice to see how the transcription factor AIRE recognizes gene promoters. Microbes in Immunotherapy – Lactobacillus johnsonii promotes the production of indole-3-propionic acid, which improves immune checkpoint blockade responsiveness. Alzheimer’s Disease Microglia – Research suggests a link between genetic risk factors for Alzheimer’s disease and microglial lipid droplet accumulation. Image courtesy of Dr. Scott Canna Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Neelika Malavige is the Head of Dengue Global Program and Scientific Affairs at the Drugs for Neglected Diseases Initiative and a Professor in the Department of Immunology and Molecular Medicine at the University of Sri Jayewardenepura. Her research focuses on dengue: its pathogenesis, vascular leak, immune correlates of protection, and biomarkers. She talks about the disease burden of dengue and her investigations into risk factors for severe disease. She also discusses her research on COVID-19 vaccines and the role of the microbiome in colon cancer, as well as how she’s working to grow research capabilities in Sri Lanka. Featured Products and Resources: Register now for IMMUNOLOGY2024, happening May 3 – 7 in Chicago! Enter to win a free lab coat from the new Lab Coats & Life Podcast. The Immunology Round Up SOX17 in Colorectal Cancer – Scientists used AKP organoids to demonstrate that SOX17 orchestrates immune evasion in the early steps of colon cancer. Tregs in Tumor Immunity – Lactate uptake by Treg cells contributes to the efficacy of CTLA-4 blockade. Astrocytes in Autoimmunity – Researchers identified astrocyte-derived heparin-binding EGF-like growth factor as a potential therapeutic target in multiple sclerosis. αβ T Cell Development – By studying patients with pre-TCRα deficiency, scientists found that pre-TCRα may not be absolutely required for αβ T cell development in humans. Image courtesy of Dr. Neelika Malavige Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. James Allison is the Regental Professor and Chair of the Department of Immunology, Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, Executive Director of the Immunotherapy Platform, and Director of the James P. Allison Institute at MD Anderson Cancer Center. Dr. Allison has spent a distinguished career studying the regulation of T cell responses and developing strategies for cancer immunotherapy. He earned the 2018 Nobel Prize in Physiology or Medicine, which he shared with Dr. Tasuku Honjo, “for their discovery of cancer therapy by inhibition of negative immune regulation.” His current work seeks to improve immune checkpoint blockade therapies currently used by clinicians and identify new targets to unleash the immune system in order to eradicate cancer. He talks about the hunt for the T cell receptor and working to bring CTLA-4 blockade into the clinic. He also discusses what’s next for immunotherapy, including future investigations into myeloid cells, and playing the harmonica in a band. Featured Products and Resources: Register now for IMMUNOLOGY2024! Enter to win a free lab coat and learn about mentorship in science. The Immunology Science Round Up Overcoming Antibacterial Resistance – A new antibiotic targets multi-drug-resistant bacteria by binding to ribosomes. Tregs in Visceral Adipose Tissue – Visceral adipose tissue harbors two distinct Treg cell populations: one enriched in males and one enriched in females. How IL-23 Fuels Tumor Growth – A subset of Tregs are responsible for the tumor-promoting effect of IL-23. Smoking and the Immune System – Smoking affects adaptive immune responses for years after quitting. Image courtesy of Dr. James Allison Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: Dr. Akiko Iwasaki is the Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University and President of the American Association of Immunologists. Francisco Gomez-Rivera is an Immunology Program Graduate Student Candidate at the University of Michigan, and Dr. Jason (Swinburne) Augustine is a retired Research Microbiologist/Immunologist at the US Environmental Protection Agency. They talk about the upcoming IMMUNOLOGY2024 meeting in Chicago, Illinois from May 3-7, 2024. They discuss key sessions to attend, what they’re looking forward to at the meeting, and advice for attendees. Featured Products and Resources: Check out the program for the IMMUNOLOGY2024 meeting. Get updates about new mentorship content. The Immunology Science Round Up Bacteria in Gastric Cancer – Streptococcus anginosus promotes gastric tumorigenesis via direct interactions with gastric epithelial cells. CAR T Cells for Aging – Senolytic CAR T cells safely eliminate senescent cells in young animals. Microbiota and Tuft Cell Biology – Microbiota calibrate type 2 immunity in the intestine by controlling tuft cell differentiation. Sex Differences in Autoimmunity – Autoantibodies to the Xist ribonucleoprotein characterize female-biased autoimmune diseases. Images courtesy of Dr. Akiko Iwasaki, Robert Lisak, Francisco Gomez-Rivera, and Dr. Jason (Swinburne) Augustine Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Dionna Williams is an Acting Associate Professor in the Department of Pharmacology & Chemical Biology at Emory University. Their research focuses on the effects of HIV infection on the brain. She talks about how HIV affects immune cells in the brain and how this can lead to neuropsychiatric symptoms. They also discuss therapeutic approaches, factors that affect how drugs can reach the brain, and moving their lab to Atlanta. Featured Products and Resources: Sign up now for IMMUNOLOGY2024, happening May 3-7 in Chicago. Get Updates about New Mentorship Content The Immunology Round Up A Long Covid Blood Signature – Active Long Covid is accompanied by a blood protein signature marked by increased complement activation and thromboinflammation. T Cells in Guillain–Barré Syndrome –Autoreactive T cells that target myelin antigens in the peripheral nerves are present in patients with the demyelinating form of Guillain–Barré syndrome. A CAR-NK Cell Clinical Trial – Researchers identified features of donated cord blood associated with improved response to CAR-NK cell therapy for B cell malignancies. Cas9-Packaging Enveloped Delivery Vehicles – Researchers developed an antibody-directed strategy for delivering genome engineering tools to specific cell types. Image courtesy of Dr. Dionna Williams Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: Dr. Akiko Iwasaki is the Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University and President of the American Association of Immunologists (AAI), and Dr. Aimee Bernard is an Assistant Professor of Immunology and Microbiology at the University of Colorado. Dr. Iwasaki has a very active presence on X, where she shares about COVID-19 research. Dr. Bernard is also active on social media through her TikTok account, and co-hosts a podcast, Help! Make It Make Sense. In this episode, they discuss the importance of communicating science to the public and strategies for social media. They also talk about how the AAI is working to share immunology knowledge with non-scientists through Immunology Explained. Featured Products and Resources: Register now for IMMUNOLOGY2024, happening May 3-7 in Chicago! Stay up-to-date with the latest in cell biology news. The Immunology Round Up A New Antibiotic for Gram-Negative Bacteria – A mechanism of lipid transport inhibition has been identified for a class of peptide antibiotics effective against resistant Acinetobacter strains. Treg Depletion As Cancer Treatment – Researchers examined the mechanism of Treg cell depletion failure using a mouse model of Treg cell–targeted immunotherapy. Immunotherapy Resistance in Melanoma – Using single-cell, spatial multi-omics, scientists showed that the tumor microenvironment promotes the emergence of a complex melanoma transcriptomic landscape. An Immune Dictionary of Cytokine Responses – Scientists created single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines in mouse lymph nodes in vivo. Images courtesy of Robert Lisak, YSM and Dr. Aimee Bernard Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies (IUIS), in Cape Town, South Africa. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending and the most memorable research presented. They discuss their experiences in South Africa, the meeting’s focus on infectious diseases and equitable science, and sessions by Nobel laureates. Featured Products and Resources: Register for IMMUNOLOGY2024, taking place May 3-7 in Chicago! STEMCELL Technologies is hiring! Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. David Gibb is an Assistant Professor at Cedars-Sinai Medical Center. His lab investigates inflammatory mechanisms in patients with sickle cell disease and lupus, focusing on mechanisms regulating immune responses to red blood cell antigens following transfusion. Featured Products and Resources: IMMUNOLOGY2024 is happening May 3-7, 2024, in Chicago. Register now! Enter to win a cell or gene therapy conference registration award. The Immunology Round Up Regulation of Lymphoid Cells – NOD1 functions in murine hematopoietic cells as a major regulator of both the generation and differentiation of lymphoid progenitors. The Aging Immune System – Type 2 memory CD4+ and CD8+ T cells increase with age and can produce more IL-4. Microglia in Cancer Metastasis – Microglia play a distinct pro-inflammatory and tumor-suppressive role in breast cancer brain metastasis. MAIT Cells in Mice and Humans – Environment influences MAIT cell development and function. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the final of five special episodes from the meeting, in which Brenda and Jason discuss sessions on integrins and ebola vaccine trials. Featured Products and Resources: Join a live webinar on January 23, 2024, to learn more about the most recent advances in CRISPR genome editing of primary cells. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the fourth of five special episodes from the meeting, in which Brenda and Jason discuss sessions on the HIV/AIDS epidemic and vaccination strategies to prepare for the next pandemic. Featured Products and Resources: Say goodbye to manual labor and hello to efficiency with RoboSep—your ultimate solution for automated cell isolation. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the third of five special episodes from the meeting, in which Brenda and Jason discuss research on T cell exhaustion in chronic infections and sex differences in immune responses. Featured Products and Resources: Achieve robust T cell expansion with high cell yield and viability using STEMCELL Technologies’ GMP-manufactured ImmunoCult-XF. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the second of five special episodes from the meeting, in which Brenda and Jason discuss research on the microbiome, sepsis, and the aging immune system. Featured Products and Resources: Perform large-volume cell processing with the Easy 250 EasySep Magnet. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the first of five special episodes from the meeting, in which Brenda and Jason discuss the opening ceremony of the congress as well as sessions on tuberculosis, γδ T cell receptors, and cancer immunotherapy. Featured Products and Resources: Isolate cells in as little as 8 minutes with EasySep Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Anjali Kusumbe is a Group Leader and Director of the Tissue Imaging Centre at Oxford University. Her lab studies vascular changes over time with the aim of treating diseases. She talks about light sheet microscopy techniques, the aging immune system, and finding lymphatic vessels in bone. Featured Products and Resources: IUIS 2023 is almost here! Enter to win $500 USD towards a cell or gene therapy conference. The Immunology Science Round Up Herpesvirus in CAR T Cell Therapy – A population of ‘super-expressor’ CAR T cells can contribute to the reactivation of latent human herpesvirus 6. Autoantibodies in NF-κB2 Deficiency – Inborn errors of the alternative NF-κB pathway underlie the production of autoantibodies against type I interferons and predisposition to viral diseases. A Rheumatoid Arthritis Atlas – Scientists built a single-cell atlas of rheumatoid arthritis synovial tissue. Tregs After Exercise – Researchers identified Tregs as a key regulatory element that is activated in response to exercise and needed to support muscle adaptations. Image courtesy of Dr. Anjali Kusumbe Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Sophia Liu is a Core Faculty Member and Early Independence Fellow at the Ragon Institute of Mass General, MIT, and Harvard. She enjoys creating new ways to measure temporally and spatially dynamic cell interactions and is particularly interested in studying T- and B-cell development. Her lab’s research focuses on immune cell interactions in tissues and dynamics across immune development and aging. She talks about the spatial mapping of T-cell receptors, what happens to the thymus during aging, and her experience starting a lab straight out of her PhD! Featured Products and Resources: Check out the program for IUIS 2023! Download a free eBook on cell separation. The Immunology Science Round Up A Functional Coronavirus Receptor – Scientists identified a functional receptor for a coronavirus that causes the common cold. Counting Immune Cells in the Human Body – An average individual’s immune system consists of approximately 1.8 trillion cells. Gut Bacteria in Type 1 Diabetes – IgG2 antibodies against three gut microbial commensals are associated with time to diagnosis and clinical response to T cell-directed therapy for type 1 diabetes prevention. Lymph Node Immune History – Tregs can form resident memory-like populations in lymph nodes after adaptive immune responses. Image courtesy of Dr. Sophia Liu Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Siobhan Burns is a Professor of Translational Immunology at University College London. Her group studies the underlying molecular and cellular mechanisms that give rise to primary immunodeficiency disorders. She talks about how genetic mutations affect immune function, and what inborn errors of immunity can teach us about general immunology. Featured Products and Resources: Check out the program for IUIS 2023! Keep current with the latest in human immunology news. The Immunology Science Round Up A Cryptic Antigen in Influenza – Researchers identified a nonclassical MHC epitope that directs the T cell response against influenza. Drug-Resistant Malaria Parasites – Scientists generated atovaquone-resistant malaria parasites and showed that they fail to transmit by mosquito. Transplanting Genetically Modified Pig Kidneys into Monkeys – Scientists showed that preclinical studies of renal xenotransplantation could be successfully conducted in nonhuman primates. Dendritic Cells to Reduce Immunosuppression After Liver Transplant – Liver transplant recipients who receive regulatory dendritic cells may require less immunosuppressive drugs. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Peter Fecci is a Professor of Neurosurgery at Duke University and the Director of the Duke Center for Brain and Spine Metastasis. His research focuses on brain tumor immunology and immunotherapy, and T cell dysfunction in glioblastoma and other intracranial cancers. He talks about activating T cells to target brain tumors and his team’s work on targeting MHC-I-negative tumor cells. Featured Products and Resources: Register now for the International Congress of Immunology in South Africa! Keep current with the latest in neural cell news. The Immunology Science Round Up A Universal Flu Vaccine Candidate – A group 2 hemagglutinin universal influenza virus vaccine candidate protects mice against group 2 influenza viruses. Regulatory T Cells in Muscle Function – Exercise induces a highly functional and stable muscle Treg phenotype. An Antiviral Drug and SARS-CoV-2 Mutations – Scientists identified a mutational spectrum from viruses in patients treated with molnupiravir. Microbial Exposure and Allergic Inflammation – Increased microbial biodiversity in mice does not protect against allergic inflammation, in contrast to what would be predicted by the hygiene hypothesis. Image courtesy of Dr. Peter Fecci Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Alice Long is an Associate Member and Principal Investigator at Benaroya Research Institute at Virginia Mason, where her lab focuses on discovering how tolerance is lost in human autoimmunity and how therapy can restore tolerance. Featured Products and Resources: Attend IUIS 2023, the world’s leading conference in the field of immunology. Keep current with Immune Regulation News The Immunology Science Round Up Insights into B Cell Selection – Antigen-presenting autoreactive B cells play a crucial role in tolerizing T cells and suppressing tissue-specific autoimmune inflammation. A New Perspective for IBD Management – Researchers discovered a polymorphism encoding a defective fusion protein that is correlated with inflammatory bowel disease severity. A Neuropeptide in Type 2 Immunity – Scientists show that neuromedin U programs eosinophils to promote mucosal immunity of the small intestine. Intestinal Antigen Recognition and Humoral Immunity – A new study shows that antigen receptor signaling and cell death resistance control intestinal humoral response zonation. Image courtesy of Alice Long Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Kristin Anderson is an Assistant Professor at the University of Virginia, where her lab focuses on engineering T cells to overcome immune suppression in the tumor microenvironment. She talks about how her cancer diagnosis changed her career focus, strategies for targeting ovarian cancer, and her transition from postdoc to professor. Featured Products and Resources: Register now for IUIS 2023! Support the culture of human T cells and enhance your cell therapy development by using high-performance, cGMP-manufactured ImmunoCult-XF medium. The Immunology Science Round Up Antibiotic Binding Site Mutations – Researchers studied the rifampicin binding site of E. coli RNA polymerase. CRISPR Screens for Cancer – Scientists combined genome-wide CRISPR screens in target cancer cells to identify pathways that regulate γδ T cell killing and BTN3A cell surface expression. Tissue-Resident T Cell Metabolism – Researchers explored the metabolic adaptations supporting differentiation, survival, and function of tissue-resident memory CD8+ T cells. Towards a Universal CAR T Cell Therapy for Blood Cancers – Epitope-edited CAR T cells were effective against patient-derived acute myeloid leukemia, B cell lymphoma, and acute T cell leukemia. Image courtesy of Dr. Kristin Anderson Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Vinod Blachandran is an Attending Surgeon and Lab Head at Memorial Sloan Kettering Cancer Center. He talks about neoantigen vaccines for pancreatic cancer, what can be learned from a rare group of long-term survivors, and how surgeon-scientist mentors have influenced his career. Featured Products and Resources: Stay up-to-date with the latest in pancreatic cell news. Register for IUIS 2023! The Immunology Science Round Up Platelet Factors in Aging – Platelet factors transfer the benefits of young blood to the aging mouse brain. Cellular Immunity in Influenza – Adaptive T cells protect against symptomatic influenza infection. Interactions Between the Immune System and the Gut Microbiome – T cells in the gut repertoire recognize several bacterial strains from complex defined communities. Aryl Hydrocarbon Receptor Signaling in Lung Endothelial Cells – Aryl hydrocarbon receptor and its ligands play an important part in protecting against tissue damage following viral pathogen infection in the lung. Image courtesy of Dr. Vinod Balachandran Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Greg Delgoffe is an Associate Professor at the University of Pittsburgh. His lab studies the intersection of metabolism and immunity in cancer. He talks about the metabolism of immune cells in cancer and the effects of nutrients in the tumor microenvironment. Featured Products and Resources: Register for IUIS 2023! Download a free wallchart on the production of CAR T cells. The Immunology Science Round Up Microbes in Diabetes Drug Responses – Researchers identified a microbiota-derived enzyme as a potential antidiabetic target. STING Can Transport Protons – Scientists analyzed STING’s structure, hypothesizing that its transmembrane domain forms a pore capable of proton transport. cGAS–STING in Neurodegeneration – The cGAS–STING signaling pathway is a critical driver of chronic inflammation and functional decline during aging. T Cells Can Kill MHC-I Negative Tumor Cells – CD8+ T cells maintain the capacity to kill tumor cells that are entirely devoid of MHC-I expression. Image courtesy of Dr. Greg Delgoffe Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Daniel Streicker is a Professor of Viral Ecology at the University of Glasgow, where his lab investigates pathogen transmission between species. He talks about vampire bats as a reservoir for rabies and approaches to vaccination that could prevent transmission. Featured Products and Resources: Register for IUIS 2023 in Cape Town, South Africa. Keep current with the latest infectious disease news. The Immunology Science Round Up Sleep Disturbance in Cardiac Disease – Sleep disruption in cardiac disease is driven by the loss of neurons that normally project from the superior cervical ganglia into the pineal gland. Influenza Vaccine Format and Antibody Responses – Using a human tonsil organoid model, researchers tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities. Multipronged T Cells – Single T cells from successful immunotherapy recognize multiple cancer types. γδ T Cells in Solid Tumors – Tumor-infiltrating γδ T cells consist of functionally distinct subsets with tumor-promoting or -restricting functions. Image courtesy of Dr. Daniel Streicker Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Jamie Spangler is an Assistant Professor at Johns Hopkins. Her lab implements a unique structure-based engineering approach to elucidate the determinants of protein activity and inform drug development. She talks about designing cytokine mimetics and how engineered cytokines could be used as therapeutics. Featured Products and Resources: Register for IUIS 2023. Activate, expand, and differentiate with cytokines, chemokines, and growth factors. The Immunology Science Round Up Microenvironment Reprogramming in Cancer Progression – Researchers developed a high-resolution tumor microenvironment atlas for gastric adenocarcinoma. Tregs and Cell Therapy for Parkinson’s Disease – Co-transplanting Tregs with iPSC-derived neurons improves cell survival. How Hepatitis C Hides from the Immune System – Flavin adenine dinucleotide capping of the hepatitis C virus protects RNA from RIG-I mediated innate immune recognition. Mast Cells in Antigen-Avoidance – Mast cell activation in the stomach lining releases leukotrienes to affect food avoidance behavior. Allergic Responses and Behavior Modification – Researchers showed that allergic sensitization drives antigen-specific avoidance behavior in mouse models of food allergy. Image courtesy of Dr. Jamie Spangler Subscribe to our newsletter! Never miss updates about new episodes. Subscribe