The Immunology Podcast

Guests: Dr. Laura Raff is Associate Director, Sales, Immunology and Dr. Ami Ashar-Patel is a Senior Account Manager, Immunology at STEMCELL Technologies. Dr. Raff has a PhD in Molecular Microbiology and Immunology from the University of Southern California and Dr. Ashar-Patel has a PhD in Biochemistry and Molecular Pharmacology from the University of Massachusetts Chan Medical School. They talk about their career transitions from academia to industry and how they support scientists’ research endeavors in their current roles. Featured Products and Resources: Register for IUIS 2023! Learn about career opportunities in biotechnology and hear advice for making the move to industry. The Immunology Science Round Up Multiplexed Screening of G-Protein-Coupled Receptors – Scientists screened 1,041 human-associated metabolites against and uncovered previously unreported endogenous, exogenous, and microbial G-protein-coupled receptor agonists. New Oral Polio Vaccines – Genetically engineered polio vaccine candidates reduce the likelihood of Sabin strains regaining fitness and neurovirulence. Fecal Transplants and Immune Checkpoint Inhibition – Fecal microbiota transfer from healthy donors promotes resolution of refractory immune checkpoint-inhibitor mediated colitis in patients with cancer. Macrophages in the Nervous System – Resident macrophages of the muscularis externa refine the enteric nervous system early in life. Images courtesy of STEMCELL Technologies Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Alessandro Sette is a Center Head, Division Head, and Professor at the La Jolla Institute of Allergy and Immunology. His lab focuses on understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. He talks about bringing a biotech mindset back to academia, cross-reactive T cell responses to SARS-CoV-2, and compiling an immune-epitope database. Featured Products and Resources: Register for the 18th IUIS International Congress of Immunology, to be held in Cape Town from 27 November-2 December 2023. Read interviews with immunologists. The Immunology Science Round Up Gut T Cells and Cancer Metastasis – A subset of CD8+ T cells from colon tumors improves control of liver tumors in a preclinical model of colorectal carcinoma. α2-adrenergic Receptors and Immunotherapy – α2-Adrenergic receptor agonists have very strong anti-tumor activity when used as monotherapies in multiple immunocompetent tumor models. Bacteria in Immune Checkpoint Blockade – Antibiotic-induced changes in gut microbiota resulted in relocation of immunosuppressive T cells from the gut to tumors. Base Editing CAR T Cells – Researchers investigated the safety of base-edited CAR T cells in three children with relapsed leukemia. Image courtesy of Dr. Alessandro Sette Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists, in Washington, DC. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending, what they were most looking forward to, and the most memorable research presented. Featured Products and Resources: Register for the International Union of Immunological Societies 2023 Congress in Cape Town, South Africa from November 27 to December 2. Prepare for your next conference. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Bana Jabri is the Sarah and Harold Lincoln Thompson Professor in the Department of Medicine and the Research Director of the Celiac Disease Center at the University of Chicago. Her research focuses on innate and mucosal immunity, particularly in celiac disease, autoimmune disorders, and inflammatory bowel disease. She talks about the mechanisms of celiac disease and new treatment options. She also discusses how the microbiome can affect immune responses in cancer. Featured Products and Resources: Stay up-to-date with the latest in immune regulation news. Download free immunology wallcharts. The Immunology Science Round Up Capsules to Study the Intestinal Environment – Scientists developed an ingestible device that collects samples from multiple regions of the human intestinal tract during digestion. T Cell Receptor Affinity – Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T cell receptor affinity to the relevant pathogen-associated antigens. Gut Bacterial Evolution Between Species – Analyses of metagenome-resolved genomes from humans and primate species reveal significant co-diversification of bacterial gut symbionts. A Pancreatic Cancer Vaccine – Researchers synthesized mRNA neoantigen vaccines in real time from surgically resected pancreatic ductal adenocarcinoma tumors. Image courtesy of Dr. Bana Jabri Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of five special episodes from the meeting. Brenda and Jason talk about sessions on mucosal immunity, emerging pathogens, and having a successful postdoctoral experience. Highlights include Dr. Isaac Chiu‘s talk on pain and mucus production in the gut, Dr. James Crowe‘s talk on monoclonal antibody discovery, and Dr. Amy Hartman’s talk on Rift Valley fever virus. Featured Products and Resources: Read interviews with immunologists. Watch videos on career development from the NIH Office of Intramural Training & Education. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting. Brenda and Jason talk about micelles for drug delivery and how helminth infection affects susceptibility to SARS-CoV-2. Featured Products and Resources: Explore Free Immunology Wallcharts Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of five special episodes from the meeting. Highlights include Dr. Anthony Fauci’s talk on the COVID-19 pandemic response and Dr. Doug Green’s talk on T cell activation. Jason and Brenda discuss sessions on immune responses in aging and obesity, and making better cancer vaccines. Featured Products and Resources: Prepare for your next conference with this toolkit. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting. Brenda and Jason discuss sessions on peripheral neuroimmune interactions and tumor cellular therapy. Highlights include the President’s Address by Dr. Mark Davis and Dr. Barbara Rehermann’s presentation on wild mouse microbiota. Featured Products and Resources: Explore STEMCELL Technologies’ workshops and resources at IMMUNOLOGY2023 Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting, in which Jason and Brenda summarize symposia on B and T-helper cells, and metabolic and gut microbiota. They discuss antigenic imprinting, lupus immunophenotyping and sex differences, dengue vaccines, and cytomegalovirus research. Featured Products and Resources: Explore STEMCELL Technologies’ workshops at IMMUNOLOGY2023 Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Prasanna Jagannathan is an Assistant Professor of Medicine in Infectious Diseases and of Microbiology and Immunology at Stanford University. His research focuses on the mechanisms of clinical immunity to malaria. He talks about how repeated exposure to malaria can lead to tolerance without symptoms, promising vaccines and treatments to prevent reinfection, and the role of innate immune cells. He also discusses shifting from religious studies to teaching to medicine, and establishing long-term collaborations with researchers in Uganda. Featured Products and Resources: We’ll see you at IMMUNOLOGY2023! Keep current with the latest immunology of infectious diseases news. The Immunology Science Round Up Blocking Psoriasis Signaling with Methotrexate – Scientists identified SLC46A2 as an important target for anti-inflammatory intervention in the skin. Tumor-Infiltrating Tregs – Researchers discovered and validated new master regulators of human tumor-infiltrating Tregs. TH9 Cells and Allergic Inflammation – JAK inhibitors may be effective for allergic patients with TH9 cell expansion. Gene Editing Primary Lymphocytes – Researchers used a CRISPR ribonucleoprotein mixed with an amphiphilic peptide to increase the yields of edited primary human lymphocytes. Peptide-Assisted Genome Editing – Scientists demonstrated rapid and efficient editing of primary cells with low cellular toxicity and no significant transcriptional perturbation. Image courtesy of Dr. Prasanna Jagannathan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Joshua Brody is the Director of the Lymphoma Immunotherapy Program at the Tisch Cancer Institute at Mount Sinai. The Brody lab studies basic and applied tumor immunology for the development of cancer immunotherapies, particularly for lymphomas and melanomas. He talks about dendritic cells to improve oncolytic virus immunotherapy and in situ vaccination to improve PD-1 blockade responses. Featured Products and Resources: IMMUNOLOGY2023 will be held May 11-15 in Washington, DC. Register now! T Cell Therapy Research: From Bench to Bedside The Immunology Science Round Up Enhancing T Cell Immunity to SARS-CoV-2 Variants – A new mRNA vaccine component elicits non-spike T cell responses in mice while maintaining spike immunity. Why Infants Are Protected from Pneumonia – Enhanced opsonophagocytosis by neonatal neutrophils improves protection against Streptococcus pneumoniae in early life. Tertiary Lymphoid Structures and Lung Cancer Immunotherapy – Researchers identified endogenous retrovirus envelope glycoproteins as a dominant antitumor antibody target in lung cancer. Engineered Bacteria As a Melanoma Vaccine – Scientists engineered a Staphylococcus epidermidis strain to express melanoma tumor antigens and tested their ability to drive antitumor immune responses. Image courtesy of Dr. Joshua Brody Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Doug Green is the Peter C. Doherty Endowed Chair of Immunology at St. Jude Children’s Research Hospital. His research focuses on the central mechanisms of cell death, survival, and the immune response. He talks about what happens when cell death fails, the role of Myc, and setting up collaborations in science. Featured Products and Resources: Register for IMMUNOLOGY2023 Watch a Free Webinar on Best Practices and Innovative Technologies for T Cell Therapy Research. The Immunology Science Round Up Gut Bacteria and Social Avoidance – Colonic γδ T cells modulate behavioral vulnerability to chronic social stress via dectin-1 signaling. Base Editing to Treat Severe Combined Immunodeficiency – Researchers used an adenine base editing strategy to restore CD3δ in autologous hematopoietic stem and progenitor cells. FcμR–IgM Interaction – Scientists used crystallography and cryo-electron microscopy to study how FcμR recognizes different forms of IgM to regulate diverse immune responses. Tissue-Resident Macrophage Differentiation – Researchers analyzed immune cells in the pleural cavity of C57BL/6 and BALB/c mice and found different responses to nematode infection. Image courtesy of Dr. Doug Green Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: Dr. Miriam Merad is the President & Scientific Programme Committee Co-Chair of the International Union of Immunological Societies (IUIS) and Dr. Mark Davis is the Scientific Programme Committee Chair. They talk about what to expect at the 2023 IUIS Congress being held November 27 – December 2 in Cape Town, South Africa. They discuss hosting the meeting in Africa, the importance of infectious disease research and international collaborations, and the highlights of this year’s program. Featured Products and Resources: Attend IMMUNOLOGY2023 May 11-15 in Washington, DC! Prepare for your next conference with this toolkit. The Immunology Science Round Up PD-L1 and Myeloid Signaling – PD-L1 promotes metastatic, but not primary, tumor growth via a cytotoxic T lymphocyte-dependent mechanism. T Cell Responses to SARS-CoV-2 – Researchers used “spheromer” peptide MHC multimer reagents to analyze T cell responses to SARS-CoV-2 infection and vaccination. ER Stress Promotes Th17 Differentiation – ER stress in intestinal epithelial cells drives gut Th17 differentiation. How Sucralose Affects T Cells – High doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation.deling and two melanoma patients. Image courtesy of Drs. Miriam Merad and Mark Davis Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Clovis Palmer is an Assistant Professor at Tulane University. He talks about how HIV hijacks metabolic processes and the role of HIF-1α in HIV infection. He also discusses using non-human primates to study SARS-CoV-2 and other viruses. Featured Products and Resources: IMMUNOLOGY2023 is taking place in Washington, DC from May 11-15th! Download free immunology wallcharts. The Immunology Science Round Up Bacterial Brain Invasion – Researchers identified a neuroimmune axis that exacerbates bacterial meningitis. CAR T Signaling Domains – Scientists engineered a logic-gated intracellular network CAR to prevent on-target, off-tumor toxicity. Cleaning Up After Apoptosis – Tingible body macrophages use cellular processes to search for and capture motile apoptotic cell fragments. Autoimmunity in Down’s Syndrome – Researchers found high levels of cytokines in individuals with Down’s syndrome, which may contribute to autoimmune susceptibility. Image courtesy of Dr. Clovis Palmer Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: Dr. Mark Davis is the President of the American Association of Immunologists, and Drs. Shruti Naik and Daniel Mucida are chairing Major Symposia at the upcoming IMMUNOLOGY2023 meeting in Washington, DC, May 11-15. They discuss what to expect at IMMUNOLOGY2023 and the highlights of this year’s program. Featured Products and Resources: Register for IMMUNOLOGY2023 by March 31 for a special discounted rate. Prepare for your next conference with this toolkit. The Immunology Science Round Up Targeting Inflammatory Skin Diseases – Researchers identified IRAK4 as a central player in skin inflammation and demonstrate its inhibition as a therapeutic strategy. CAR T for a Rare Disease – CD19 CAR T therapy successfully treated a patient with refractory antisynthetase syndrome T Cell Receptor Genes from Archaic Humans – A subset of T cell receptors were traced to Neanderthals in Eurasian populations. Self-Reactive T Cell Receptors – Scientists identified a population of CD4+ T cells within the endogenous repertoire that exhibit hallmarks of overt self-reactivity. Image courtesy of Drs. Mark Davis, Shruti Naik, and Daniel Mucida Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Hao Wu is the Asa and Patricia Springer Professor of Structural Biology at Harvard Medical School. Her lab focuses on the molecular and cellular mechanisms that govern the assembly, regulation, and therapeutic intervention of supramolecular complexes in innate immunity. She talks about cryo-electron microscopy and how her team used it to study the structures of the NLRP3 inflammasome disc, the B cell antigen receptor, and the Gasdermin D pore. She also discusses the role of AlphaFold in structural biology research. Featured Products and Resources: Register for IMMUNOLOGY2023! Make the most of your conference experience with this toolkit. The Immunology Science Round Up Graft-Versus-Host Disease and the Microbiome – In graft-versus-host disease, pathogenic T cells disrupt the intestinal microbiome by altering ambient oxygen levels. Extracellular Matrix Binding of Interferon-γ – Local interferon-γ retention protects organisms from systemic toxicity during prolonged immune stimulation. Lipid Metabolism in T Cells – Phospholipid saturation drives effector T cell function. Inhibiting Peanut Allergy – An inhibitor prevents antibody binding and mast cell activation in a humanized mouse model of peanut allergy. Image courtesy of Dr. Hao Wu Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Caroline Sokol is a Principal Investigator at Massachusetts General Hospital and an Assistant Professor of Medicine at Harvard Medical School. Her lab studies the innate immune control of allergic disease. She talks about the role of sensory neurons and dendritic cells in allergic responses and insights into allergies from her son’s first bee sting. Featured Products and Resources: Register for IMMUNOLOGY2023! How to Isolate Tregs Using Easy 50 EasySep Magnet The Immunology Science Round Up Microbiome Transmission – Researchers identified microbiome transmission patterns from mother to infant and between cohabitating individuals. Long-Lasting T Cells – By repeatedly immunizing generations of mice, scientists found that functional T cells can proliferate well beyond the lifespan of the organism. Dietary Cholesterol and Humoral Immune Responses – Researchers revealed tissue-restricted modulation of IgA secretion by plasma cells that is centered around dietary cholesterol metabolites. γδ T cells in Immunotherapy – γδ T cells contribute to the response to immune checkpoint blockade in patients with cancers with HLA class I defects. Image courtesy of Dr. Caroline Sokol Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: In this special episode, Brenda and Jason chat with Drs. Daylon James and Arun Sharma, the hosts of the Stem Cell Podcast. Recorded in-person and led by Dr. Nicole Quinn from STEMCELL Technologies, the four hosts discuss the impact that podcasting has had on their careers and how it can make science and scientists more accessible. They also talk about the future of science communication and advice for young scientists pursuing careers in academia and industry. Featured Products and Resources: Register for IMMUNOLOGY2023 taking place May 11-15 in Washington, DC. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Miriam Merad is a Professor of Cancer Immunology and Director of the Marc and Jennifer Lipschultz Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai. Her research focuses on dendritic cells and macrophages. She talks about tissue-resident macrophages in COVID-19 and cancer. She also discusses her new role as President of the International Union of Immunological Societies and bringing the international immunology community together at their upcoming meeting in South Africa. Featured Products and Resources: Early-Bird Registration Is Open for IMMUNOLOGY2023! Free Wallchart: SARS-CoV-2 Structure and Life Cycle The Immunology Science Round Up NLRP3 Inflammasome Activation – Researchers used cryo-EM to identify the structure of the active NLRP3 inflammasome disk. How the BCG Vaccine Induces Trained Immunity – The BCG vaccine triggers epigenetic modifications on alveolar macrophages via an intestinal microbiota-mediated pathway. Immunotherapy for Type 1 Diabetes – Scientists examined the mechanism of action of low-dose interleukin-2 immunotherapy and identified a long-lived gene expression signature associated with potential anti-inflammatory effects. pH Affects Interleukin-2 Anti-Tumor Activity – Researchers identified an interleukin-2 variant that retains its binding affinity in low pH environments. Image courtesy of Dr. Miriam Merad Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Jie Sun is the Harrison Professor of Medicine at the University of Virginia. His lab studies respiratory immunology under homeostasis and disease conditions. He talks about how long COVID compares to other post-viral conditions, and his lab’s work investigating mucosal immunity from mRNA vaccines. Featured Products and Resources: Abstract Submission Is Open for IMMUNOLOGY2023! Studying COVID-19 with Air-Liquid Interface Cultures The Immunology Science Round Up Cardiac Autoimmunity – C-Met+ T cells are selectively increased in the circulation and in the myocardium of patients with inflammatory cardiomyopathies. A Universal Flu Vaccine – Scientists developed an mRNA–lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known influenza A virus subtypes and influenza B virus lineages. mRNA Export Rates and Gene Expression – The nuclear export efficiency of innate immune mRNAs varies such that for many genes, only a small fraction of the newly synthesized pre-mRNA reaches the cytoplasm. Dendritic Cells for Long-Term Tumor Control – Expanding cross-presenting dendritic cells enhances oncolytic virotherapy. Image courtesy of Dr. Jie Sun Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Arthur Liesz is a Professor of Experimental Neurology at the University of Munich. The Liesz lab is interested in the interplay between the brain and the immune system after stroke. He talks about the inflammatory response to stroke, including T cell-modulated microglial activation. He also talks about stroke aftermath, including T cells that remain in the brain and the redistribution of function during recovery. Featured Products and Resources: Keep Current with the Latest in Neural Cell News. Explore Free Immunology Wallcharts. The Immunology Science Round Up The Microbiome and Metabolome – Researchers dissected the interplay between the gut microbiome and host genome. Personalized T Cell Therapy – Scientists isolated and cloned multiple T cell receptors recognizing mutational neoantigens. An Ancestral Tuberculosis Effector Promotes Dissemination – Researchers linked an unusual tuberculosis outbreak with high rates of dissemination and skeletal disease to a specific effector. A Broadly Neutralizing Influenza Vaccine – Co-immunization with hemagglutinin stem immunogens derived from influenza A viruses elicited cross-group protection. Image courtesy of Dr. Arthur Liesz Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Vijay Kuchroo is the Samuel L. Wasserstrom Professor of Neurology at Harvard Medical School. His major research interests include the role of co-stimulation in autoimmune diseases, as well as cell surface molecules and regulatory factors that regulate the induction of T cell tolerance and dysfunction. He talks about the conditions necessary to differentiate Th17 cells and their role in autoimmunity. He also discusses his group’s discovery of Tim-3, an inhibitor receptor on T cells which is now being exploited for cancer immunotherapy. Featured Products and Resources: Resources for Your T Cell Therapy Research Read interviews where immunologists tell their stories, discuss their research, and voice their thoughts and opinions on current topics in immunology. The Immunology Science Round Up Disrupting Calcium Homeostasis – Researchers showed that inherited variants in ITPR3 alter physiologically relevant Ca2+ signaling responses, driving defects in immune responses. Light Chain Coherence in Antibodies – Among naturally occurring antibodies that have adapted to particular antigens, those with similar heavy chains usually have similar light chains. Anti-CTLA-4 Antibodies Reprogram the Tumor Microenvironment – Scientists used single-cell RNA sequencing to dissect the immune response to anti-CTLA-4 blockade. An Intranasal Booster for Sarbecoviruses – Researchers used a SARS-CoV-2 intranasal spike booster to elicit mucosal immune memory within the respiratory tract. Image courtesy of Dr. Vijay Kuchroo Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: Dr. Kristin Patrick is an Assistant Professor and Dr. Robert Watson is an Associate Professor at Texas A&M University. Their joint lab investigates innate immune regulation during bacterial infection. They talk about gasdermin D and cell death in tuberculosis, and how running a lab together helps them prioritize mentorship. Featured Products and Resources: Use Easy250 EasySepTM Magnet for rapid immune cell isolation from large-volume samples. Win $300 worth of refreshments to fuel your immunology journal club! The Immunology Science Round Up Black Death and Immune Evolution – Researchers identified loci associated with Black Death survival that are also associated with increased susceptibility to autoimmune diseases. How a Pathogen Inhibits Pyroptosis – A phosphatase secreted by Mycobacterium tuberculosis suppresses pyroptosis by hijacking ubiquitin. B Cell Antigen Receptor Structure – Scientists report the cryogenic electron microscopy structure of the mouse B cell antigen receptor assembly. How Pain Protects the Gut – Pain receptors regulate gut microbiota and protect tissues from inflammation. Image courtesy of Drs. Kristin Patrick and Robert Watson Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Henrique Borges da Silva is an Assistant Professor at the Mayo Clinic in Arizona. His main research focus is determining how extracellular nucleotides affect transcriptional, metabolic, and functional mechanisms of CD8+ T cells in response to viral infections and cancer. He talks about where extracellular ATP comes from, and how there could be a link between ATP and ADP immunological signaling and the powers of caffeine. Featured Products and Resources: Win $300 worth of refreshments to fuel your immunology journal club! Keep current with the latest in Human Immunology News. The Immunology Science Round Up Telomere Transfer in T Cells – An interaction between T cells and antigen presenting cells early in the immune response to viruses may determine how fast T cells decline. APOE and COVID-19 Outcomes – APOE variants associated with Alzheimer’s disease are also associated with a reduced immune response and increased mortality from COVID-19. Protecting the Brain from Infection – Scientists identified a new blood-endothelial barrier that separates olfactory mucosa from circulating antibodies. Bacterial Colonization in the Intestine – An oral bacterium associated with inflammatory bowel disease uses nitrate respiration to colonize the intestine. Image courtesy of Dr. Henrique Borges da Silva Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Indira Mysorekar is a Professor of Medicine and Chief of Basic and Translational Research at Baylor College of Medicine. Her lab studies host–microbial interactions in the urinary bladder and the placenta. She discusses the role of the microbiome and the aging immune landscape in recurrent urinary tract infections. She also talks about her research on Zika and SARS-CoV-2 in the placenta. Featured Products and Resources: Win $300 worth of refreshments to fuel your immunology journal club! Prepare for your next conference with this toolkit. The Immunology Science Round Up Gut Bacteria and Cancer Pathogenesis – Some commensal bacteria promote the development of retrovirus-induced leukemia. Generating Tolerance to Microbiota – RORγ-expressing cells are responsible for the induction of Tregs in the gut. Antigen-Presenting Cells Promote Treg Generation – New research reveals parallel pathways for establishing tolerance to self and foreign antigens in the thymus and periphery. Tissue Destruction in Sjögren’s Syndrome – Sjögren’s syndrome may be caused by self-reactive CD8+ cytotoxic T cells. CAR T Therapy for Lupus – Anti-CD19 CAR T cell treatment led to remission of systemic lupus erythematosus in a trial of five patients. Image courtesy of Dr. Indira Mysorekar Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Ruth Ley is Managing Director of the Max Planck Institute for Biology Tübingen and Director of the Department of Microbiome Science. Dr. Sara Clasen is a postdoctoral fellow in the same lab. Together, they’re interested in the co-evolution of humans with their microbiomes. They use basic science to investigate the evolutionary history of gut microbes, how they have adapted to life inside humans, and how they affect human biology and health. More recently, they published a pre-print on the silent recognition of flagellins from human gut commensal bacteria by TLR5. Featured Products and Resources: Explore immunology wallcharts. Access STEMCELL’s conference toolkit. The Immunology Science Round Up Hair Follicles and Mites – Scientists show that innate type 2 immunity controls hair follicle commensalism by Domedex mites. The Search for a Shared Neoantigen – Using quantitative immunopeptidomics, researchers have identified a tumor stroma-specific target for T cell therapy. Gut Microbes Surf the IgA Cycle – New research suggests that circadian networks comprising intestinal IgA, diet, and microbiota converge to align circadian biology in the intestine and to ensure host-microbial mutualism. A New Way to Make CAR-T Cells – Researchers have successfully generated non-viral, gene-specific targeted CAR-T cells through CRISPR-Cas9. Images courtesy of Drs. Ruth Ley and Sara Clasen Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Leonardo Ferreira is an Assistant Professor of Microbiology and Immunology at the Medical University of South Carolina. The Ferreira lab uses CARs and other engineered immune receptors to dissect how specificity, affinity, and signaling modulate the function of different T cells subsets in tolerance and immunity. He talks about how CAR Tregs could prevent transplant rejection and treat Type 1 diabetes. He also discusses mixing and matching immune cells, the freedom to pursue multiple ideas in academia, and science outreach in Bolivia. Featured Products and Resources: Stay up-to-date with the latest in cell therapy news. Download a free wallchart on the production of CAR T cells. The Immunology Science Round Up T Cell Nutrient Use – CD8+ T cells preferentially consume lactate over glucose in response to Listeria infection. Blocking Malaria Transmission – A stabilized malaria antigen induces transmission-blocking antibody responses. A New Metabolic Pathway in Inflammatory Macrophages – Research suggests that L-ornithine could improve LACC1-associated immunological dysfunctions such as arthritis or inflammatory bowel disease. T Cell Receptor Avidity – Scientists studied how T cell receptor avidity of tumor-specific T cells affected their anti-tumor capabilities using mouse modeling and two melanoma patients. Image courtesy of Dr. Leonardo Ferreira Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Karen Edelblum is an Assistant Professor of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School. She discusses γδ T cells and immune-epithelial cross-talk in inflammatory bowel disease. She also talks about intravital microscopy and decorating immunology-themed cakes! Featured Products and Resources: Stay up-to-date with the latest in intestinal cell news. Use EasySep to isolate highly purified immune cells in as little as 8 minutes. The Immunology Science Round Up Highlights from the Gastrointestinal Tract XX Conference – Researchers presented on food tolerance and sensitization, gut cytokines and drug metabolism, the link between C. diff and colon cancer, and more. Programming Tissue Residency in T Cells – Researchers showed that distinct programs of tissue residency are induced in CD8+ and CD4+ tissue-resident memory T cell subsets, a difference attributable to Runx3 activity. How Prokaryotes Recognize Pathogens – Scientists showed that NLR-based immune pattern recognition is prevalent in bacteria and archaea. Image courtesy of Dr. Karen Edelblum Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Jonathan Kipnis is the BJC Investigator and Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology at Washington University in St. Louis. His lab investigates the complex interactions between the immune and nervous systems. He talks about immune activity and surveillance in the brain, and how T cell subsets affect brain function and behavior. He also discusses the brain’s immune reservoir and his lab’s work on cerebrospinal fluid-regulated immune cell mobilization. Featured Products and Resources: Explore free immunology wallcharts. Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center. The Immunology Science Round Up Intranasal Vaccines for HIV and SARS-CoV-2 – Researchers developed vaccines that use the neonatal Fc receptor to mediate transmucosal uptake and elicit immune responses at both local and distal mucosal sites. How ADAR1 Mutation Leads to Autoimmune Responses – Scientists found that ZBP1-dependent signaling underlies the autoinflammatory pathology caused by the alteration of ADAR1. Preventing Autoinflammation – Researchers identified ADAR1 as a negative regulator of ZPB1-mediated apoptosis and necroptosis, providing insights into the pathology of Aicardi–Goutières syndrome. Averting Interferon Induction – ZBP1 promotes type I interferon activation and fatal pathology in mice with impaired ADAR1 function. The Interleukin-17 Ligand-Receptor Axis – Scientists explored the explore the structural basis for interleukin-17 family signaling. Image courtesy of Dr. Jonathan Kipnis Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Mark Kaplan is the Chair of the Department of Microbiology and Immunology at Indiana University School of Medicine. He is currently the Editor-In-Chief for the American Association of Immunologists’ journal ImmunoHorizons. Much of Dr. Kaplan’s work has focused on understanding the function of transcription factors in the development of T helper cell subsets. He talks about the role of T helper 9 cells in lung inflammation and γδ T cells in wound healing. He also discusses ImmunoHorizons and how it provides a home for solid immunological research that may otherwise remain unpublished. Featured Products and Resources: Stay up-to-date with the latest papers and news in your field. Read interviews with immunologists who tell their stories, discuss their research, and voice their thoughts and opinions on current topics in immunology. The Immunology Science Round Up IL-33 Secretion in Airway Inflammation – Researchers showed that in airway epithelial cells, gasdermin D pores mediate IL-33 release. Immune Tolerance to Food – CD4+ T cells respond to food peptides by proliferating weakly in secondary lymphoid organs of the gut–liver axis owing to the action of Tregs. Why Brain Injuries Lead to Seizures – Thalamic inflammation enhances seizure risk in mice after brain injury. B Cells in the Lungs – Influenza and SARS-CoV-2 infection generates bona fide and bystander lung-resident memory B cells. Image courtesy of Dr. Mark Kaplan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Laura Mackay is a Professor and Laboratory Head at the Peter Doherty Institute for Infection and Immunity at the University of Melbourne. She talks about her tissue-resident memory T cell research and her ongoing collaboration with Pfizer to identify and validate new targets for cancer therapy. Featured Products and Resources: Isolate cells in as little as 8 minutes with EasySep Webinar: Accelerating T Cell Therapy Research The Immunology Science Round Up Breast Cancer Metastasis During Sleep – Researchers showed that most spontaneous circulating tumor cell intravasation events occur during sleep. Harnessing Anti-Cytomegalovirus Immunity Against Solid Tumors – Cytomegalovirus-derived peptide epitopes promote long-term antitumor immunity in murine cancer models. A Gut Metabolite Promotes Nerve Repair – Fasting increases production of indole-3 propionate, which enhances axonal regeneration. Tregs and Hair Growth – After acute hair loss, Tregs communicate with hair follicle stem cells to stimulate stem cell proliferation and hair regrowth. Image courtesy of Dr. Laura Mackay Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Mark Shlomchik is UPMC Endowed Distinguished Professor and Chair of the Department of Immunology at the University of Pittsburgh. He is also a Founder and Chief Scientific Officer of BlueSphere Bio, a company working to create individualized T cell therapies for the treatment of cancer. Dr. Shlomchik’s lab focuses on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis. He talks about the role of toll-like receptors in lupus, how his autoimmune disease research led to potential cancer therapies, and starting a biotech company with his brother. Featured Products and Resources: Explore Free Immunology Wallcharts Immunology Profiles is a venue where immunologists tell their stories, discuss their research, and voice their thoughts and opinions on current topics in immunology. The Immunology Science Round Up Antibody Escape in Omicron Subvariants – Researchers showed that the BA.4 and BA.5 SARS-CoV-2 sub-lineages contain mutations that reduce neutralization from vaccines and previous infection. Long COVID in the Brain – After mild respiratory COVID, mice displayed elevated CSF cytokines, impaired hippocampal neurogenesis, decreased oligodendrocytes, and myelin loss. Pregnancy and Intracellular Infection – Pregnancy-induced post-translational antibody modification enables protection against the prototypical intracellular pathogen Listeria monocytogenes. Sex-Specific Immune Responses to Tumors – Scientists demonstrated that sex-related differences in tumor burden depend on adaptive immunity. Image courtesy of Dr. Mark Shlomchik Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Hanover Matz is a Postdoctoral Fellow at the University of Maryland, who recently completed his PhD under the supervision of Dr. Helen Dooley. He discusses why sharks may have evolved adaptive immune systems, the role of T cells, mucosal immunity, and antibodies, and working with sharks in the lab. Featured Products and Resources: Keep current with the latest in immune regulation news. Use Easy250 EasySep magnet for rapid immune cell isolation from large-volume samples. The Immunology Science Round Up Intestinal Epithelium and Response to Viral Infection – A new study has uncovered a protective role for intraepithelial Ly6A+CCR9+CD4+ T cells against enteric viral infection. New Mechanism to Activate Cancer-Killing T Cells – Scientists have identified a new mechanism, known as MHC-1 cross-dressing, that is effective in promoting a T cell response. Long Covid and Breakthrough Infections – Researchers determined that vaccination against SARS-CoV-2 before infection offers partial protection in the post-acute phase of the disease. Tregs in Traumatic Brain Injury – Targeted delivery of interleukin 2 boosts the number of anti-inflammatory immune cells within the brain to restrict inflammation and damage following injury or stroke. Image courtesy of Dr. Hanover Matz Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Michael Alonso is a Scientific Co-Founder, and Vice President of Immunology & Pharmacology at Bolt Biotherapeutics, a biotechnology company developing immunotherapies that activate myeloid cells. He discusses targeting tumors by covering them in “eat me” signals, considerations for moving drugs into the clinic, and building teams in biotech. Featured Products and Resources: Read interviews with immunologists who tell their stories, discuss their research, and voice their opinions on current topics in immunology. Explore scientific resources for your immunology research. The Immunology Science Round Up Trade-Offs in Cancer Mutations – Researchers developed a model of hotspot mutations that shows fundamental trade-offs between a tumor’s growth and its visibility to the immune system. Reversing the T Cell Immune System – To determine how T cell lineage fates are determined in the thymus, scientists generated ‘FlipFlop’ mice with a functionally reversed T cell immune system. Gut Microbiota and Response to Viral Infection – Suppression of gut microbiota renders mice susceptible to systemic viral infections. Europe Cancer Immunotherapy Meeting Highlights – Scientists discussed antigenic dominance in lung cancer, next-generation CAR T cell design, and combining CAR T cell therapy with vaccination for solid tumors. Image courtesy of Dr. Michael Alonso Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Alice Long is an Associate Member of the Center for Translational Immunology at Benaroya Research Institute at Virginia Mason. The Long lab is focused on understanding how tolerance is lost in autoimmunity, specifically as it related to type 1 diabetes. Dr. Long discusses the work she presented at the American Association of Immunologists’ annual meeting, IMMUNOLOGY2022, on CD8 T cell exhaustion and Treg modulation. Featured Products and Resources: Use EasySep to isolate highly purified immune cells in as little as 8 minutes. AAI 2022 Talks Block Symposium: Autoimmunity – CD8 T cell exhaustion is reduced in subjects with autoimmune-associated DR4 risk alleles Saturday, May 7, 2022 | 10:15 AM – 12:15 PM | Oregon Ballroom 203 NextGen Transformative Immunologic Therapies for Human Disease – Treg modulation by IL-2 mutein therapy Sunday, May 8, 2022 | 8:00 AM – 10:00 AM | Room A107–109 Image courtesy of Dr. Alice Long Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Shruti Naik is an Assistant Professor of Biological Sciences at New York University Langone Medical Center. She studies immunity in the epithelial tissues that line our body to understand how environmental stimuli collaborate with genetic factors to influence health and drive disease at these interfaces. She discusses the work she’s presenting at the American Association of Immunologists’ annual meeting, IMMUNOLOGY2022, on trained immunity and immune-epithelial crosstalk in tissue repair.   Featured Products and Resources: Easy 250 EasySep Magnet for Large-Scale Immunomagnetic Separation AAI 2022 Talks Back to School: A Review of Four Fast-Moving Fields – Trained immunity Friday, May 6, 2022 | 2:00 PM – 4:00 PM | Oregon Ballroom 204 International Cytokine and Interferon Society (ICIS) Symposium: Rising Stars of Cytokine Biology – Immune-epithelial crosstalk in tissue repair Sunday, May 8, 2022 | 3:45 PM – 5:45 PM | Room B110–112 Image courtesy of Dr. Shruti Naik Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Gwendalyn Randolph is the Emil R. Unanue Distinguished Professor in the Department of Immunology and Pathology at Washington University in St. Louis. Research in her lab integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and lymphatic vessel biology. She discusses the work she’s presenting at the American Association of Immunologists’ annual meeting, IMMUNOLOGY2022, on the diversity, function, and mysteries of peritoneal macrophages. Featured Products and Resources: Follow these tips to prepare for your next conference. AAI 2022 Talks Major Symposium B: Macrophage Biology, Diversity, and Inflammation – Diversity, function, and mysteries of peritoneal macrophages Saturday, May 7, 2022 | 8:00 AM – 11:30 AM | Portland Ballroom 254–255 Careers in Science Lecture and Roundtables – Becoming a confident scientist and embracing your authentic self Sunday, May 8, 2022 | 12:30 PM – 2:00 PM | Portland Ballroom 251 Image courtesy of Dr. Gwendalyn Randolph Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Michael Rosenblum is a Professor of Dermatology at the University of California, San Francisco. His lab seeks to to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. They are currently investigating how regulatory T cells (Tregs) control immune responses in tissues, as well as their “alternative” functions. He talks about early-life inflammation and type 2 helper T cells in the skin, and how Tregs can be manipulated to target autoimmune diseases and cancer. Featured Products and Resources: Stay up-to-date with the latest in immune regulation news. Download the cell separation e-book, a practical guide on everything you need to know about cell isolation techniques. The Immunology Science Round Up Tissue-Resident Memory T Cells in the Brain – After viral brain infection, tissue-resident memory T cells triggered central nervous system inflammation, promoting autoimmune reactions in mice. Suppressing HIV with Antibodies – Anti-HIV-1 antibodies can maintain viral suppression and may accelerate viral reservoir decay. Enhancing Hepatitis B Therapeutic Vaccine Responses – Natural killer cell depletion enhanced T cell responses to a chimp adenoviral vectored hepatitis B virus. CAR T Cell Cytotoxicity in Glioblastoma – Researchers found that interferon gamma signaling is crucial for proper engagement and killing of solid tumors by CAR T cells. Image courtesy of Dr. Michael Rosenblum Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Gary Koretzky is President of the American Association of Immunologists, Vice Provost for Academic Integration at Cornell University, Professor of Medicine at Weill Cornell Medicine, and Director of the Cornell Center for Immunology. He talks about how he began his career in immunology, using science to guide Cornell’s response to COVID-19, and what to expect at AAI’s Immunology 2022 meeting taking place May 6-10th. Featured Products and Resources: Use Easy250 EasySep Magnet for rapid immune cell isolation from large-volume samples. Tips to prepare for your next conference or networking event The Immunology Science Round Up Circular RNA Vaccines Against SARS-CoV-2 Variants – Circular RNA vaccines enable effective protection against SARS-CoV-2 in mice and monkeys. CD20+ T Cells in Multiple Sclerosis – Scientists found that expansion of CD20+ T cells contributes to the inflammatory process in patients with multiple sclerosis and mice with autoimmune encephalomyelitis. Neutrophils in Wound Healing– Neutrophils have an essential role in transferring matrix into wounds through heat shock–integrin signaling. Spinal Microglia Promote Pain Recovery – Scientists identified a CD11c+ spinal microglia population that appears after pain development and is essential for recovery from neuropathic pain. Image courtesy of Dr. Gary Koretzky Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Florian Krammer is a Professor of Vaccinology at Icahn School of Medicine at Mount Sinai. His lab focuses on understanding broadly-reactive immune responses against the surface glycoproteins of RNA viruses such as influenza, with the goal to develop better vaccines and novel therapeutics. He talks about his lab’s shift to COVID-19 research, strategies for vaccine development, and how we can prepare for future pandemics. Featured Products and Resources: Keep current with the latest in immunology of infectious disease news. Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center. The Immunology Science Round Up The Microbiome’s Effects on CAR T Therapy Outcomes – Exposure to broad spectrum antibiotics prior to CAR T therapy was associated with worse survival and increased neurotoxicity. Identifying Genes That Improve T Cell Proliferation – Researchers tested over 12,000 genes and identified positive regulators of T cell functions. Fungi in Inflammatory Bowel Disease – Scientists identified fungal strains that induce intestinal inflammation in patients with ulcerative colitis. Neuroimmune Communication via Cerebrospinal Fluid – Cerebrospinal fluid gains direct access to the skull bone marrow niches and regulates immune responses. Image courtesy of Dr. Florian Krammer Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Andy Kokaji is a Senior Director of Immunology, and Dr. Hannah Lee is a Senior Director of Product Management, at STEMCELL Technologies. They discuss their career paths and how they develop and commercialize products to support scientists worldwide. Featured Products and Resources: Keep current with the latest in human immunology news. STEMCELL is hiring! The Immunology Science Round Up mRNA Boosters Increase Antibodies but Not Side Effects – A Moderna booster vaccine elicited neutralizing titers that were statistically significantly higher than the peak titers detected after the primary vaccination series. B Cells in Unexpected Places – Researchers showed that glycan-mediated B cell suppression plays a key role in establishing fetomaternal tolerance in mice. A Data Analysis Tool to Predict Disease Outcomes – Scientists identified immune cell types associated with increased risk of death from COVID-19. Tertiary Lymphoid Structures in Renal Cell Cancer – Researchers used spatial transcriptomics to examine B cell responses within tertiary lymphoid structures. Image courtesy of Drs. Andy Kokaji and Hannah Lee Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Jennifer Gommerman is a Professor of Immunology at the University of Toronto. Her team has uncovered a novel gut-brain axis that regulates neuroinflammation and is examining the role of B lymphocytes in Multiple Sclerosis (MS) patients and in animal models of MS. More recently, she has been studying the antibody response to SARS-CoV-2 in saliva samples from patients with COVID-19. Featured Products and Resources: Keep current with the latest immune regulation research. Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center. The Immunology Science Round Up Neutralizing Antibody Responses to Omicron – SARS-CoV-2-specific immunity wanes over time after two mRNA vaccine doses. Determining T Cell Fate – Researchers identified T cell antigen receptor sequence features that promote regulatory T cell fate. Fungi in the Gut – Mucosa-associated fungi protect mice against intestinal injury and infection via interleukin-22-dependent mechanisms. T Cells in Glioblastomas – T cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10. Image courtesy of Dr. Jennifer Gommerman Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Caetano Reis e Sousa is the Assistant Research Director and Senior Group Leader at the Francis Crick Institute. His lab studies the molecular pathways that trigger dendritic cells into action. He talks about the mechanisms of dendritic cell cross-presentation, RNA interference, and dendritic cell progenitors in influenza. Featured Products and Resources: Differentiate Human Monocytes into Dendritic Cells with ImmunoCult Dendritic Cell Culture Kit The STEMdiff Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells. The Immunology Science Round Up T Cell Responses to Omicron – T cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins. Curing Cancer with CAR T Therapy – Ten years after treatment, two leukemia patients remained in remission and had long-persisting CD4+ CAR T cells. Vimentin Helps SARS-CoV-2 Enter Endothelial Cells – Vimentin could facilitate SARS-CoV-2 infection and contribute to vascular complications associated with COVID-19. Probing T Cell Function with CRISPR – Researchers mapped the functional gene networks regulating interleukin-2 and interferon gamma in human T cells. Image courtesy of Dr. Caetano Reis e Sousa Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Francesco Colucci is a Wellcome Investigator and Professor of Immunology at the University of Cambridge. His research focuses on natural killer (NK) and other innate lymphoid cells, as well as immunogenetics. He talks about uterine NK cells and their education, and falling in love with research as a physician. Featured Products and Resources: Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center. Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes. The Immunology Science Round Up A Link between Epstein-Barr Virus and Multiple Sclerosis – Researchers used data from millions of US military recruits to determine that Epstein-Barr infection increased the risk of multiple sclerosis. Nano-Sponges to Treat Inflammation – Nanodecoys coated with a macrophage membrane scavenged pro-inflammatory cytokines in autoimmune disease models. How Epstein-Barr Infection Triggers Multiple Sclerosis – Scientists showed that molecular mimicry between an Epstein-Barr virus protein and a neuronal molecule in Multiple sclerosis patients contributes to neuroinflammation. The Immunoregulatory Landscape of Tuberculosis – Researchers identified how cellular composition and immunoregulatory pathways in tuberculosis granulomas relate to peripheral immune responses. Image courtesy of Dr. Francesco Colucci Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Mihai Netea is a Professor of Experimental Medicine at Radboud University Nijmegen and a Professor of Immunometabolism at the University of Bonn. He discusses the mechanisms of trained immunity, transmission of immune traits across generations via epigenetics, and how some vaccines can enhance immunity to other pathogens. Featured Products and Resources: Keep current with the latest in human immunology news. Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes. The Immunology Science Round Up Fc-Mediated Responses to SARS-CoV-2 – mRNA vaccination, but not infection, produced spike antibodies that maintained Fc receptor binding to SARS-CoV-2 variants of concern. A Nasal Vaccine for Tuberculosis – An adenovirus-vectored tuberculosis vaccine induced airway tissue-resident memory CD4 and CD8 T cells. Behavioral Immune Landscapes of Inflammation – Researchers used 4D live imaging to obtain behavioral descriptors of individual cells and build behavioral landscapes. Platelet Aggregation in Sepsis – Scientists showed that inhibiting NFAT in activated mouse and human platelets enhanced their aggregation. Image courtesy of Dr. Mihai Netea Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. De’Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania. The Herbert lab is exploring the immunoregulatory and regenerative mechanisms operating at the mucosal interface. He discusses his recent paper on IL-33 sources and secretion, his postdoctoral fellowship in South Africa, and the M1/M2 macrophage paradigm. Featured Products and Resources: Keep current with the latest in immune regulation. Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes. The Immunology Science Round Up TREM-2 and T Cells in SARS-CoV-2 – Researchers showed that triggering receptor expressed on myeloid cells 2 (TREM-2) expression was increased on T cells in patients with COVID-19. Neutralizing the Omicron Variant – mRNA vaccine boosters may increase SARS-CoV-2 neutralizing antibody titers. T Cells Still Recognize the Omicron Variant – Early data suggest that existing CD8+ T cell responses from previous SARS-CoV-2 infection or vaccination will likely recognize the Omicron variant of concern. A Nasal Vaccine for Influenza – An intranasal flu vaccine enhanced immunoglobulin A responses through lung-resident memory B cells, plasmablasts, and plasma cells in mice. Mucosal Antibody Responses to SARS-CoV-2 Vaccination – Mucosal immunoglobulin A responses to mRNA vaccination depend on pre-existing immunity. An Alternative Approach for Anthrax – Scientists used capsule depolymerase to remove the Bacillus anthracis bacterial capsule and promote phagocytosis and killing by human neutrophils. Image courtesy of Dr. De’Broski Herbert Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Keke Fairfax is an Associate Professor of Microbiology and Immunology and the Director of Equity, Diversity, and Inclusion at the University of Utah. Her lab uses helminth parasite Schistosoma mansoni as a tool to understand the consequences of IL-4 induced immuno-modulation. She explains how helminth infections can reduce the efficacy of childhood vaccinations, and how mentorship and networking can help minority scientists thrive in Utah. Featured Products and Resources: Keep current with the latest in infectious disease research. Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center. The Immunology Science Round Up Early HIV Treatment Needed to Replenish Memory T Cells – Delaying HIV treatment leads to irreversible loss of tissue-resident memory T cells and reduced protection against HPV-related cancer. Neoepitopes in Melanoma – Researchers found that adoptive cell therapy success is associated with an expansion of neoepitope-specific CD8+ T cells. Immunotherapy for Peanut Allergy – Scientists showed that patients’ responses to an oral immunotherapy for peanut allergy depends on both pre-existing CD4+ T cells and a subset of T helper cells. An mRNA Vaccine for Tick-Borne Diseases – Researchers developed an mRNA vaccine against the tick that transmits Lyme disease. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Tri Phan is a Senior Research Fellow at the Garvan Institute of Medical Research and a Conjoint Professor at the University of New South Wales. He runs the Intravital Microscopy Lab, which aims to understand the checks and balances that control B cell responses. His team uses two-photon microscopy to image cells in live animals, including time-lapses of over 24 hours. He talks about the physics behind this type of microscopy and how it can image deep within tissues without destroying them. We also discuss his lab’s recent Cell paper on osteomorphs, a newly discovered cell type involved in osteoclast recycling in bone, and their work on memory B cells in lymph nodes. Featured Products and Resources: STEMCELL Technologies is Hiring! The STEMdiff Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells. The Immunology Science Round Up Blocking SARS-CoV-2 Replication – A Therapeutic Interfering Particle reduces SARS-CoV-2 viral load by competing for viral replication machinery. Pre-Existing T Cells Abort SARS-CoV-2 Infection – Health care workers who were exposed to COVID-19, but repeatedly tested negative, had pre-existing RNA-polymerase-specific T cells. A Self-Guarded Immune Sensing Pathway – MORC3 inhibits viral replication and its degradation by a virus unleashes a secondary antiviral response. T Cell States in Adoptive Cell Therapy – Host T cell reactivation drives the immune response and determines the outcome of lymphocyte infusion in leukemia patients. Image courtesy of Dr. Tri Phan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Jenny Ting is the William R. Kenan Jr. Distinguished Professor of Genetics at the University of North Carolina at Chapel Hill, and served as the President of the American Association of Immunologists from 2020-2021. Her lab discovered the NLR protein family, and their recent research interests include oxidative phosphorylation in HIV, the role of AIM2 in autoimmunity, and microbes that can protect from radiation. Featured Products and Resources: Keep current with the latest in immune regulation research. Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes. The Immunology Science Round Up Replication Stress Response Defects in Cancer – Replication stress response defects led to single-stranded DNA accumulation in cancer cells and improved responses to immune checkpoint blockade. Responses to Immune Checkpoint Inhibition in Renal Cell Carcinoma – Researchers identified baseline pre-treatment T cell receptor clonality as a predictor of immunotherapy response in renal cell carcinoma. DNA Methylation Signatures of Immune Cells – Scientists found that adaptive and innate immune cells show distinct methylation and gene expression patterns. Comparing SARS-CoV-2 Variants – The Delta variant spike protein can fuse membranes more efficiently at low levels of cellular receptor ACE2 compared to other variants. Learn more about SARS-CoV-2 entry into cells in this review. The New York Times Coronavirus Vaccine Tracker Image courtesy of Dr. Jenny Ting Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Dario Vignali is the Frank Dixon Chair in Cancer Immunology and Vice Chair and Professor of Immunology at University of Pittsburgh School of Medicine. His lab studies various aspects of T cell regulation, and recently generated a new mouse model to target conventional CD4 T cells. Featured Products and Resources: Keep current with the latest in immune regulation research. Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes. The Immunology Science Round Up Dual Targeting for B Cell Leukemia – CAR T therapy targeting both CD19 and CD22 showed clinical activity and low toxicity in a Phase I trial, but strategies to further improve CAR T cell persistence are needed. Microbial Fitness in the Intestine – Researchers showed that microbial exposure leads to the selection of antigen-specific intestinal plasma cells with a diverse Ig gene repertoire. Less Is More for COVID-19 Vaccine Dosage – A 1000-fold lower prime dose of an adenovirus-based SARS-CoV-2 vaccine followed by a standard boost dose elicited superior immune responses compared to two standard doses. IL-33 in Inflammation Resolution – IL-33 induces metabolic reprogramming, which controls the differentiation of alternatively activated macrophages that contribute to the resolution of inflammation and tissue repair. Image courtesy of Dr. Dario Vignali Subscribe to our newsletter! Never miss updates about new episodes. Subscribe