The Allo Podcast

Molly and Bethany address the common question many families wonder about what to do to monitor their HDFN baby once they’re home, and how to know when baby is finally cleared of HDFN. They share their children’s post-discharge monitoring plans, which cover a full spectrum of HDFN severity.If you haven’t already, listen to Season 1 Episode 13 about the neonatal HDFN period. Common terms discussed in this episode: Newborn hemolytic anemiaNewborn hyperbilirubinemia Hemoglobin/hematocritReticulocytesErythropoietin/darbepoetin/ESAsThrombocytopeniaNeutropeniaPediatric hematologistExample transfusion thresholds provided in our Excellent Neonatal Care Practices resource here.References in this episode: Clinical study showing the effectiveness of ESAs for neonatal HDFN: Ree IM, de Haas M, van Geloven N, Juul SE, de Winter D, Verweij EJ, Oepkes D, van der Bom JG, Lopriore E. Darbepoetin alfa to reduce transfusion episodes in infants with haemolytic disease of the fetus and newborn who are treated with intrauterine transfusions in the Netherlands: an open-label, single-centre, phase 2, randomised, controlled trial. The Lancet Haematology. 2023 Dec 1;10(12):e976-84.Watch this episode on YouTubeView all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.

Bethany and Molly address iron and its dangers to the HDFN newborn in this quick, science-based episode. Together they address the dangers of iron overload and the confusion around why iron is often mistakenly included in the treatment regimen for newborns experiencing alloimmunized anemia, as well as treatments for extreme conditions. Watch this episode on YouTubeView all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.References in this episode: Study on iron overload at birth in HDFN newborns: Rath ME, Smits-Wintjens VE, Oepkes D, Walther FJ, Lopriore E. Iron status in infants with alloimmune haemolytic disease in the first three months of life. Vox Sang. 2013 Nov;105(4):328-33. doi: 10.1111/vox.12061. Epub 2013 Jun 27. Available here.Case report of iron overload resolving: Adam DL, Bowes L, Goodyear L, Moorehead PC. Conservative Management of Hyperferritinemia in Hemolytic Disease of the Fetus and Newborn: A Case Report and Review of the Literature. J Pediatr Hematol Oncol. 2021 Mar 1;43(2):73-76. Available here.

Katie rejoins Bethany and Molly to discuss the NICU experience including why HDFN babies sometimes need NICU time, how long and how often NICU is necessary, what to expect to hear and see in the NICU, and important resources to prepare and navigate an HDFN NICU experience.Watch this episode on YouTubeView all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.References in this episode:Neonatal excellent care checklist: available here. HDFN Health Record: available here. Merch store to get a “I wear my sunglasses at night” onesie: access here.

In this quick, science-focused episode, Molly and Bethany break down how IVIG (intravenous immunoglobulin) is used during alloimmunized pregnancies to help delay fetal anemia and reduce the risks of severe HDFN. They explain who may benefit, how the treatment works, what the latest guidelines say, and why IVIG can be a life-saving tool when started early and used thoughtfully.Watch this episode on YouTubeView all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyReferences in this episode: New meta-analysis on use of IVIG: Mustafa HJ, Sambatur EV, Pagani G, D’Antonio F, Maisonneuve E, Maurice P, Zwiers C, Verweij JE, Flood A, Shamshirsaz AA, Jouannic JM. Intravenous immunoglobulin for the treatment of severe maternal alloimmunization: individual patient data meta-analysis. American journal of obstetrics and gynecology. 2024 Oct 1;231(4):417-29. Available here.Benefits of delaying first IUT to beyond 20 weeks: Lindenburg IT, van Kamp IL, van Zwet EW, Middeldorp JM, Klumper FJ, Oepkes D. Increased perinatal loss after intrauterine transfusion for alloimmune anaemia before 20 weeks of gestation. BJOG. 2013 Jun;120(7):847-52. Available here.Pregnancy management guidelines: Moise KJ, Markham KB, Spinella PC, Sherwood MR, Robinson KA, Wilson LM, Malone J, Espinoza J, Dizon-Townson D, Mercer L, Miller R. A Clinical Practice Guideline for the Management of Pregnancy Alloimmunized to Red Blood Cell Antigens. JAMA Network Open. 2025 Nov 3;8(11):e2544649-. Available here. Note that additional practice points are in the supplemental content. To access all recommendations, practice points, and their rationale, we recommend clicking “supplemental content”, downloading the file, and accessing Table 4. This provides all information in one table for easy printing and reference.Please consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.

Join Bethany and Molly in an interview with Kate and Dewayne as they recount their experience with a tragic preventable loss due to HDFN followed by the redemption of a beautiful living son. Part two takes our listeners through Kate’s most recent pregnancy, managed by Dr. Trevett, with a joyful ending.Show themes: Anti-D, Anti-C alloimmunized pregnancyHigh titerIVIG/plasmapheresisIntrauterine transfusions Healthy outcome with the right careWatch this episode on YouTubeView all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.

Join Bethany and Molly in an interview with Kate and Dewayne as they recount their experience with a tragic preventable loss due to HDFN followed by the redemption of a beautiful living son. In part one, the group discusses Kate and Dewayne’s experience with a loss that resulted in her sensitization, and Kate’s next pregnancy that ended with the tragic discovery of Kate’s condition at the end of the pregnancy. Stay tuned for the redemption story in Part 2.Show themes: Anti-D, Anti-C alloimmunized pregnancyHigh titerFull-term loss due to HDFNPrevious pregnancy loss and medical trauma Watch this episode on YouTubeView all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.Please consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.

Bethany and Molly share all about plasmapheresis, including photos and videos and practical tips to give their listeners a clear picture of what it is and when it’s used in cases of severe HDFN. Watch this episode on YouTubeView all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.References in this episode: Benefits of delaying first IUT to beyond 20 weeks: Lindenburg IT, van Kamp IL, van Zwet EW, Middeldorp JM, Klumper FJ, Oepkes D. Increased perinatal loss after intrauterine transfusion for alloimmune anaemia before 20 weeks of gestation. BJOG. 2013 Jun;120(7):847-52. Available here.Use of plasmapheresis: Lei Y, Liang Y, Hao X, Zhu W, Zhang X, Zheng Z, Wang X. Double-filtration plasmapheresis as an adjunct to therapy for severe early-onset maternal erythrocyte alloimmunization. BMC Pregnancy and Childbirth. 2025 Nov 7;25(1):1169. Available here.

403 The New HDFN Guidelines: A Historic Moment for FamiliesIn this historic episode of the Allo Podcast from the Allo Hope Foundation, hosts Bethany Weathersby and Molly Sherwood celebrate the release of new evidence-based, expert-backed, and patient-informed guidelines for the prevention and management of Hemolytic Disease of the Fetus and Newborn (HDFN). They discuss why these comprehensive guidelines were urgently needed to address longstanding care gaps, highlight key prenatal and neonatal recommendations that could save lives, and share the unique collaborative process behind their creation. Listeners are encouraged to access and implement these guidelines to improve outcomes for alloimmunized families.Watch this episode on YouTubeAccess all guidelines resources on our guidelines landing page (we upload the published manuscripts and associated resources as they become available): https://allohopefoundation.org/clinical-practice-guidelines/Pregnancy management guidelines: Moise KJ, Markham KB, Spinella PC, Sherwood MR, Robinson KA, Wilson LM, Malone J, Espinoza J, Dizon-Townson D, Mercer L, Miller R. A Clinical Practice Guideline for the Management of Pregnancy Alloimmunized to Red Blood Cell Antigens. JAMA Network Open. 2025 Nov 3;8(11):e2544649-. Available here. Note that additional practice points are in the supplemental content. To access all recommendations, practice points, and their rationale, we recommend clicking “supplemental content”, downloading the file, and accessing Table 4. This provides all information in one table for easy printing and reference.If you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.Our most sincere thank you to all clinicians and patients involved in the guidelines development process, including: Philip Spinella, MD; Christine Leeper, MD; Molly Sherwood; Bethany Weathersby, MEd; Mark Yazer, MD; Cassandra Josephson, MD; Jennifer Andrews, MD; Kenneth Moise Jr, MD; Timothy Bahr, MD; Allison Ayapantecatl; Nick Carr, DO, FAAP; Ravi Patel, MD; Robert Christensen, MD; Sarah Ilstrup, MD; Jon Watchko, MD; Karen Robinson, PhD, MSc; Lisa Wilson, ScM; Anthony Sciscione, DO; Donna Dizon-Townson, MD; Jimmy Espinoza, MD, Msc; Juan González Vélez MD, PhD; Kara Markham, MD; Laura Mercer, MD, MBA, MPH; Leonardo Pereira, MD, M.C.R.; Russell Miller, MD; Saul Snowise, MD; Alireza Shamshiraz, MD; Thomas Trevett, MD; Andre Cap, MD, PhD; Jeanne Hendrickson, MD; Paul Ness, MD; Ross Fasano, MD; Stella Chou, MD; Alyssa Ziman, MD; Barbara Gaines, MD; Bryan Cotton, MD, MPH; Denis Snegovskikh, MD; Donald Jenkins, MD; Frank Guyette, MD; Jason Sperry, MD; Jay Malone, MD, MS, PhD; COL Jennifer Gurney, MD; Joseph Sakran, MD, MPA, MPH; Juan Duchesne, MD; Katie Shanahan, CPNP; Nancy Dunbar, MD; Pampee Young, MD; Rich Gammon, MD; Susan Stern, MD; CAPT Travis Polk, MD

Bethany and Molly make a mini episode all about cell free fetal DNA, the blood test on mom that can determine a baby’s antigen status beginning around 10 weeks gestation. This is an accurate, non-invasive way to find out if a baby is at risk of HDFN by capturing free-floating fetal DNA from the mother’s blood and testing it to see if baby has the antigen that the mom’s antibodies may attack, causing HDFN. We also suggest listening to Season 1 Episode 2 about Prenatal Blood Tests.Watch this episode on YouTubeCffDNA is officially recommended in the recently published clinical practice guidelines (listen to previous episode, S4E3, for more information about the guidelines): Moise KJ, Markham KB, Spinella PC, Sherwood MR, Robinson KA, Wilson LM, Malone J, Espinoza J, Dizon-Townson D, Mercer L, Miller R. A Clinical Practice Guideline for the Management of Pregnancy Alloimmunized to Red Blood Cell Antigens. JAMA Network Open. 2025 Nov 3;8(11):e2544649-. Available here. Note that additional practice points are in the supplemental content. To access all recommendations, practice points, and their rationale, we recommend clicking “supplemental content”, downloading the file, and accessing Table 4. This provides all information in one table for easy printing and reference.Options for cffDNA in various countries: cffDNA from Sanquin Laboratories (Netherlands; can be shipped internationally) (D, E, C, c, K) Information here.cffDNA from BillionToOne’s Unity Screen (U.S.) (D, E, C, c, K, Fya) Publication here. Order form here.cffDNA from Natera’s Panorama test (U.S.) (D) Information here.cffDNA from NHS (UK/Ireland) (D, E, C, c, K) Information here.cffDNA from Canadian Blood Services (D, E, C, c, K; 16-20 weeks gestation) Information here.cffDNA from Lifeblood (Australia) (D, E, K, k, E, c, Fya, Fyb; 12 weeks gestation) Information here.More resources about cffDNA: Moise Jr KJ. The use of free DNA for fetal RHD genotyping in the Rh negative pregnant patient—the time has come. American Journal of Obstetrics and Gynecology. 2025 Feb 1;232(2):188-93. Available here.Gandhi M. Paternal and Fetal Genotyping in the Management of Alloimmunization in Pregnancy. Available here.Regan F, Veale K, Robinson F, Brennand J, Massey E, Qureshi H, Finning K, Watts T, Lees C, Southgate E, Robinson S. Guideline for the investigation and management of red cell antibodies in pregnancy: A British Society for Haematology guideline. Transfusion Medicine. Available here.View all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.

When Kayla discovered anti-Kell antibodies at just 12 weeks, a sky-high titer and a terrifying 1.64 MCA score at 15 weeks sent her and her husband on a same-day flight from Pennsylvania to Austin, Texas for an emergency intraperitoneal transfusion—the first of nine lifesaving IUTs that would turn them into frequent flyers and the Dell Children’s fetal team into family. Kayla’s story is a powerful reminder that when the stakes are your child’s life, you do whatever it takes—and that knowledge, advocacy, and the right medical team really do save babies.Show themes: Anti-K alloimmunized pregnancyHigh-titer alloimmunized pregnancyLong-distance travel for specialty care Intrauterine transfusionPhenobarbital (for the mother prior to delivery)Darbepoetin (in the newborn with HDFN)Severe HDFN survivalWatch this episode on YouTubeView all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click Here to make a one-time or recurring donation.References in this episode: Neonatal best practices document that Kayla used in the NICU: Read here.Phenobarbital before delivery to help mature fetal liver: Trevett Jr TN, Dorman K, Lamvu G, Moise Jr KJ. Antenatal maternal administration of phenobarbital for the prevention of exchange transfusion in neonates with hemolytic disease of the fetus and newborn. American journal of obstetrics and gynecology. 2005 Feb 1;192(2):478-82. Read here.Use of erythropoietin or darbepoetin to reduce the number of top-up transfusions in babies with HDFN and a history of IUT: Ree IM, de Haas M, van Geloven N, Juul SE, de Winter D, Verweij EJ, Oepkes D, van der Bom JG, Lopriore E. Darbepoetin alfa to reduce transfusion episodes in infants with haemolytic disease of the fetus and newborn who are treated with intrauterine transfusions in the Netherlands: an open-label, single-centre, phase 2, randomised, controlled trial. The Lancet Haematology. 2023 Dec 1;10(12):e976-84. Read Here

Bethany and Molly kick off Season 4 with a dive into the weirdest corners of HDFN — from mind-blowing bizarre facts (like babies born with 100% donor blood and drones parachuting blood bags in Africa) to rare case studies featuring anti-Kell + anti-D, the ultra-rare anti-KU and anti-PP1P˩K antibodies, and a mystery about false-positive newborn screens that still has experts stumped.Watch this episode on YouTube Do you have any ideas about why some infants who have received IUTs test (falsely) positive for certain metabolic syndromes in their newborn screens? E-mail us at [email protected] all of our resources at www.allohopefoundation.orgIf you are an alloimmunized mother from any country, you are welcome in our Facebook support group called “Antibodies in Pregnancy: An AHF Support Group. Join here. https://www.facebook.com/groups/antibodiesinpregnancyPlease consider donating to AHF. If you are a listener, you know we do a lot with a little. Not sure how much will make a difference? An antibody screen in Kenya costs $13 USD. A dose of RhIG for a mother who cannot afford it is $80 USD. Click here to make a one-time or recurring donation.References in this episode: Read more about the “grandmother effect” here where a female fetus can become exposed to her mother’s Rh(D) positive blood in utero, priming her for Anti-D sensitization: here.Gender as a risk factor for developing neutropenia in HDFN: Alkhani A, Arefi A, AlTayeb M, Naaz S, Alghanbar J, Alhuthil R, Alrowaily F, Almidani E. Incidence and risk factors of neutropenia in neonates with hemolytic disease of the newborn. International Journal of Pediatrics and Adolescent Medicine. 2024 Sep 1;11(3):83-7. Available here.; Blanco E, Johnston DL. Neutropenia in infants with hemolytic disease of the newborn. Pediatric blood & cancer. 2012 Jun;58(6):950-2. Available here.Read about drone delivery of blood in Rwanda: here.Anti-PP1PK literature review and case presentations: Di Ciaccio P, Cutts B, Alahakoon TI, Dennington PM, Soo LA, Curnow J. Clinical consequences of the extremely rare anti‐PP1Pk isoantibodies in pregnancy: a case series and review of the literature. Vox Sanguinis. 2021 May;116(5):591-600. Available here.

New Episodes of the Allo Podcast coming to a podcast platform near you 1-27-25.

Bethany and Molly close out Amanda’s incredible survival story that began in Episode 2 of this season (Low Titer Pregnancies). After a rapid increase in titers from too low to titer to 2,048, Amanda’s referral to an MFM team went unnoticed for a few weeks. By the time she was seen, her son was very sick, but he was in the right hands with Dr. Snowise and his team. Listen to this miraculous story unfold. Then, Bethany and Molly reflect on AHF’s accomplishments and goals for the year and close with a powerful reflection that will touch the hearts of every listener, ending with a special dedication. References in this episode: Nipocalimab trial results: NipocalimabUse of cffDNA to find fetal antigen status for D, E, C, c, K, Fya: Fetal Antigen StudyESAs for newborns with HDFN to reduce the number of transfusions: Transfusion ReductionDonate to AHF: Allo Hope DonateAHF Merch: Allo Hope MerchWatch this episode on YouTube: Allo Hope on YouTubeJoin the AHF patient support group: AHF Support Facebook

Bethany, Katie and Molly talk together about how their parenting is affected during and after the life-changing experience of an alloimmunized pregnancy.Donate to AHF: Allo Hope DonateAHF Merch: Allo Hope MerchWatch this episode on YouTube: Allo Hope on YouTubeJoin the AHF patient support group: AHF Support Facebook

Bethany and Molly interview Dr. Timothy Bahr, a neonatologist with a specialty in neonatal hematology about all of your HDFN questions for newborns. Dr. Bahr patiently answers many of the common challenges and questions in neonatal HDFN care. This is an advanced discussion of neonatal HDFN. For a primer describing disease presentation, visit our neonatal episode in Season 1.Questions answered in this episode:What does it entail to prepare blood for a neonatal exchange transfusion?When and how do you use erythropoietin/darbepoetin (ESAs)?When does an HDFN baby need to be referred to hematology after discharge?Heel prick versus blood draw from a vein, does it matter?Is it ok to do transcutaneous bilirubin readings (with a small device on the skin instead of blood draw)?When is a baby cleared from HDFN?Why can’t we have the same neonatologist throughout a baby’s NICU stay?How can a mother politely insist on regular laboratory testing for their newborn with HDFN?How can a mother explain to the team at birth that it’s very important to get an immediate bilirubin check at birth (through cord or placenta if possible)?What’s the difference between neonatal and pediatric hematologist?Publications mentioned in this episode: Delayed cord clamping in alloimmunization: https://www.sciencedirect.com/science/article/abs/pii/S2589933323003075Iron overload in HDFN: https://scholarlypublications.universiteitleiden.nl/access/item%3A2881417/download#page=194Systematic review on IVIG in the neonate for HDFN: https://fn.bmj.com/content/99/4/F325.shortLeiberman et al on IVIG in the neonate for HDFN: https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.18170Darbepoetin to reduce the need for neonatal transfusion: https://cdn.clinicaltrials.gov/large-docs/26/NCT03104426/Prot_000.pdfPublications by Dr. Tim Bahr: https://pubmed.ncbi.nlm.nih.gov/?term=Bahr_TMPublications by Tim’s mentor, Dr. Robert (Bob) Christensen: https://pubmed.ncbi.nlm.nih.gov/?term=Christensen_RDDonate to AHF: Allo Hope DonateAHF Merch: Allo Hope MerchWatch this episode on YouTube: Allo Hope on YouTubeJoin the AHF patient support group: AHF Support Facebook

Bethany and Molly interview Dr. Timothy Bahr, a neonatologist with a specialty in neonatal hematology about all of your HDFN questions for newborns. Dr. Bahr patiently answers many of the common challenges and questions in neonatal HDFN care. This is an advanced discussion of neonatal HDFN. For a primer describing disease presentation, visit our neonatal episode in Season 1.Questions answered in this episode:What is this research you’re doing on measuring hemolysis in a fetus from the mother’s breath?Can you still have delayed cord clamping in alloimmunized pregnancies? Can I hold my baby for a few minutes before they are taken to the NICU?Why are HDFN babies offered iron so often?How quickly does a baby’s bilirubin level improve (go down) after an exchange transfusion?What is your opinion on using IVIG on the neonate for HDFN, and when would you do it?Publications mentioned in this episode: Delayed cord clamping in alloimmunization: https://www.sciencedirect.com/science/article/abs/pii/S2589933323003075Iron overload in HDFN: https://scholarlypublications.universiteitleiden.nl/access/item%3A2881417/download#page=194Systematic review on IVIG in the neonate for HDFN: https://fn.bmj.com/content/99/4/F325.shortLeiberman et al on IVIG in the neonate for HDFN: https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.18170Darbepoetin to reduce the need for neonatal transfusion: https://cdn.clinicaltrials.gov/large-docs/26/NCT03104426/Prot_000.pdfPublications by Dr. Tim Bahr: https://pubmed.ncbi.nlm.nih.gov/?term=Bahr_TMPublications by Tim’s mentor, Dr. Robert (Bob) Christensen: https://pubmed.ncbi.nlm.nih.gov/?term=Christensen_RDDonate to AHF: Allo Hope DonateAHF Merch: Allo Hope MerchWatch this episode on YouTube: Allo Hope on YouTubeJoin the AHF patient support group: AHF Support Facebook

Bethany and Molly build on last season’s discussion of grief to expand to anxiety, stress, depression and PTSD during and after the experience of a high risk pregnancy. They talk through how these challenges present themselves, how they feel to an alloimmunized mother, and specific coping mechanisms. The close with a positive segment called “what’s in the bag”, where moms submitted lists of items that they packed for their delivery, IUT, and NICU visits.Mental health burden in alloimmunized pregnancy: https://www.ajog.org/article/S0002-9378(23)01145-6/pdfDonate to AHF: Allo Hope DonateAHF Merch: Allo Hope MerchWatch this episode on YouTube: Allo Hope YouTubeJoin the AHF patient support group: AHF Support Facebook

Bethany, Molly and Katie talk through all aspects of Rh Immune Globulin (RhOGAM, WinRho, RhIG). They cover the history, how it’s made, its safety profile, understanding the RhIG shortage, and public health controversy. The women provide information for Rh negative women who are deciding whether or not to accept the RhIG injection for a pregnancy. Do you live in the U.S. and have Anti-D antibodies? You could be paid more than $100 per plasma donation (up to twice a week) with reimbursement for travel to a donation center. E-mail us at [email protected] and Bethany, Katie or Molly will respond to confirm your potential eligibility and refer you directly to our personal contact at Kedrion. Learn about Kedrion, the manufacturer of RhoGAM: https://www.kedrion.com/therapies/RhoGAM website: https://www.rhogam.com/Donate to AHF: Allo Hope DonateAHF Merch: Allo Hope MerchWatch this episode on YouTube: Allo Hope on YouTubeJoin the AHF patient support group: AHF Support Facebook

Bethany, Molly and Katie talk through differences in HDFN care continent by continent. They review country-specific research, practice patterns, and patient stories. Donate to AHF: Allo Hope DonateAHF Merch: Allo Hope MerchWatch this episode on YouTube: Allo Hope on YouTubeJoin the AHF patient support group: AHF Support FacebookCross-matching for Kell in Netherlands: Luken JS, Folman CC, Lukens MV, Meekers JH, Ligthart PC, Schonewille H, Zwaginga JJ, Janssen MP, van Der Schoot CE, van der Bom JG, de Haas M. Reduction of anti‐K‐mediated hemolytic disease of newborns after the introduction of a matched transfusion policy: a nation‐wide policy change evaluation study in the Netherlands. Transfusion. 2021 Mar;61(3):713-21. Iceland study: Gudlaugsson B, Hjartardottir H, Svansdottir G, Gudmundsdottir G, Kjartansson S, Jonsson T, Gudmundsson S, Halldorsdottir AM. Rhesus D alloimmunization in pregnancy from 1996 to 2015 in Iceland: A nation‐wide population study prior to routine antenatal anti‐D prophylaxis. Transfusion. 2020 Jan;60(1):175-83. South Korea study: Yang EJ, Shin KH, Song D, Lee SM, Kim IS, Kim HH, Lee HJ. Prevalence of unexpected antibodies in pregnant Korean women and neonatal outcomes. The Korean Journal of Blood Transfusion. 2019 Apr 30;30(1):23-32. Saudi Arabia study: Alkhaibary A, Ali M, Tulbah M, Al-Nemer M, Khan RM, Al Mugbel M, Al Sahan N, Hassounah MM, Alshammari W, Kurdi WI. Complications of intravascular intrauterine transfusion for Rh alloimmunization. Annals of Saudi Medicine. 2021 Nov;41(6):313-7.Iran study: Niroomanesh S, Dadgar S, Shirazi M, Sharbaf FR, Golshahi F. Neonatal outcomes of Rh alloimmunization pregnancy treated with intrauterine transfusion. Med. Sci.. 2020;24(101):57-65.Japan study: Mizuuchi M, Murotsuki J, Ishii K, Yamamoto R, Sasahara J, Wada S, Takahashi Y, Nakata M, Murakoshi T, Sago H. Nationwide survey of intrauterine blood transfusion for fetal anemia in Japan. Journal of Obstetrics and Gynaecology Research. 2021 Jun;47(6):2076-81.Canada study: Jackson ME, Baker JM. Hemolytic disease of the fetus and newborn: historical and current state. Clinics in Laboratory Medicine. 2021 Mar 1;41(1):133-51.Brazil study: Pares DB, Pacheco GH, Lobo GA, Araujo Júnior E. Intrauterine Transfusion for Rhesus Alloimmunization: A Historical Retrospective Cohort from A Single Reference Center in Brazil. Journal of Clinical Medicine. 2024 Feb 28;13(5):1362.

On listener request, Bethany and Molly dedicate an episode to the friends and family of the alloimmunized mother. They reintroduce themselves, explain alloimmunization and HDFN and what to expect from an alloimmunized pregnancy, and give concrete advice on how to support someone navigating this disease. Read a description of HDFN on the National Organization for Rare Disorders website written by AHF: NORD: HDFNMental health burden in alloimmunized pregnancy: AJOG: Mental Health and HDFNDonate to AHF: DonateAHF Merch: MerchWatch this episode on YouTube: Allo YouTubeJoin the AHF patient support group: Facebook Groupwww.allohopefoundation.org

In true Bethany and Molly fashion, the hosts open with laughing at inappropriate stories and end in happy tears sharing the most heartfelt moments of love and appreciation for each other and this special community. One Tiny Thing is a compilation of patient-provided “tiny things” that happened to them and changed everything. Bethany and Molly discuss listener answers to these special questions:What is one tiny thing that could have saved your HDFN baby’s life? What is one tiny thing that did save your HDFN baby’s life? What is one tiny thing that someone said to you that changed your perspective on this experience? Donate to AHF: https://allohopefoundation.org/get-involved/donate/AHF Merch: https://allo-hope-foundation.myspreadshop.com/Watch this episode on YouTube: allohope youtubeJoin the AHF patient support group: https://www.facebook.com/groups/antibodiesinpregnancy

Bethany and Molly return to record with Dr. Markham, a well-loved maternal fetal medicine specialist who has treated many HDFN babies. They cover many questions submitted by allo moms including: Does a high titer or low titer mean the baby is antigen positive or negative? If mom’s antibodies are too low to titer, what does that mean for the rest of the pregnancy? Is it too risky to pursue another pregnancy with a titer of 2,048? Is it safe to have an external cephalic version (ECV) for breech babies in alloimmunized pregnancy? What is the best mode of delivery for an alloimmunized pregnancy? When should we deliver if the pregnancy didn’t need IUTs? If the pregnancy is low titer? Can antibodies cause hydrops or death without a high MCA Doppler ultrasound first? How has a patient made you, the doctor, feel valued? Can obesity make IUTs more difficult? The women close with some patient-submitted stories of the most shocking thing that happened during an IUT, with Dr. Markham sharing a hilarious one of her own. Delivery timing 37-38 weeks: ACOG Medically Indicated Late Term and Early Preterm Deliveries. Donate to AHF: https://allohopefoundation.org/get-involved/donate/AHF Merch: https://allo-hope-foundation.myspreadshop.com/Watch this episode on YouTube:Join the AHF patient support group: https://www.facebook.com/groups/antibodiesinpregnancy

S3E2: Low Titer Alloimmunized Pregnancies Over half of alloimmunized pregnancies begin with a low antibody titer, and a portion stay low throughout the pregnancy. Others begin low and later rise to critical levels. This episode is dedicated to management of the low titer pregnancy and how to anticipate a potential change in disease trajectory if titers increase. Bethany and Molly include management recommendations and stories submitted by low titer moms before transitioning to a special interview with allo mom Amanda, whose pregnancy began as a low titer pregnancy before taking a surprising turn. We meet Amanda in this episode before resuming the second half of her HDFN journey in this season’s final episode, Incredible HDFN Survival Stories. Key aspects of low titer disease management: Determine baby’s antigen status if possible. If not possible, monitor as if antigen positive. If the baby is certainly antigen negative, the pregnancy proceeds as normal and there is no need to do anything further beyond standard pregnancy careEstablish care with an MFM and determine up front if this MFM is able to do IUTs on your baby if your disease progresses. If not, have a referral plan set upCheck titers every 4 weeks in the first and second trimester, then every 2 in the third trimesterWeekly fetal assessment beginning at 32 weeks (Nonstress tests and biophysical profiles).Delivery at 37-38 weeksFollow all neonatal recommendations (establish a plan with pediatrician in advance if possible b/c they are likely to be doing the follow-up care) - bilirubin consistent with AAP guidelines which may include daily testing after discharge for a week or more, and hemoglobin/hematocrit weekly for the first six weeks and until hemoglobin/hematocrit increases or is in stable normal range for two consecutive weeksDelivery timing 37-38 weeks: ACOG Medically Indicated Late Term and Early Preterm Deliveries. ACOG Early Delivery GuidlinesAAP guidelines for hyperbilirubinemia after birth: AAP on HyperbilirubinemiaUndetectable antibodies progressing to severe disease: Dajak S, Stefanović V, Čapkun V. Severe hemolytic disease of fetus and newborn caused by red blood cell antibodies undetected at first‐trimester screening (CME). Transfusion. 2011 Jul;51(7):1380-8. Undetected Antibodies ResearchAmanda’s video blog of her alloimmunized pregnancy journey: Amanda's Video BlogDonate to AHF: https://allohopefoundation.org/get-involved/donate/AHF Merch: https://allo-hope-foundation.myspreadshop.com/Watch this episode on YouTube: https://youtu.be/AA9J1pHPNUAJoin the AHF patient support group: https://www.facebook.com/groups/antibodiesinpregnancy

S3E1: Top 5 Things to Save HDFN Babies Bethany and Molly begin Season 3 with a review of the episodes ahead before challenging each other to list what they think are Top 5 things that would keep the most HDFN babies safe. The episode takes a turn when they reveal that they have signed themselves up for plenty more than 5 things (listed below). Donate to AHF: https://allohopefoundation.org/get-involved/donate/AHF Merch: https://allo-hope-foundation.myspreadshop.com/Watch this episode on YouTube:YouTube The Essential 5Join the AHF patient support group: https://www.facebook.com/groups/antibodiesinpregnancyTop 5 Prenatal Things (in no particular order): Bethany:Quick referral to MFM (and a list of MFMs worldwide who specialize in treating alloimmunized pregnancies)Preventative medications accessible to all women who need them (Rh immune globulin/RhoGAM; intravenous immune globulin, plasmapheresis for severely affected pregnancies)Weekly, accurate MCA scans beginning at 16-17 weeks for those with critical titers or previously affected babies; for those with early onset severe disease, starting soonerMFMs who collaborate with other experts and refer when necessaryIUTs performed on time, using fetal paralytic meds, by providers with ample experience performing IUTs who know to space and attempt the last IUT at 34-35 weeks if possible(Honorable mention): Referring all women with positive antibody screen to Allo Hope Foundation (Honorable mention): Delivery at 37-38 weeks unless you are certain baby is antigen negativeMolly: Immediate referral to MFM after positive antibody screenWeekly MCA scans for critical titer/previously affected pregnancies (Weekly MCA recommendation from the group who developed MCA scans: www.academia.edu) Establishing global referral centers for IUTsAn awareness that the seriousness of the disease can change at any time (e.g., low titers can jump up, first pregnancies can be severely affected - will result in closer monitoring)Go in if you notice a change in baby’s movement or something doesn’t feel right about your treatment or monitoringTop 5 Neonatal Things (in no particular order): Molly:Establishing neonatal care in advance of delivery (NICU/hematology in cases where pregnancy has needed treatment or high titers; pediatrician for lower titers)Create a fetal care record for your baby (AHF is developing this and it is not yet publicly available: e-mail us at [email protected] if you would like to use a draft version in the interim)Following bilirubin closely after birth and doing a trial off of lights before discharge (AAP hyperbilirubinemia guidelines: aap.org/pediatricsWeekly hemogobin/hematocrit after discharge until consistently trending upward or stable in a healthy range for 2+ weeks (Neonatal management from the Netherlands: research.rug.nlFollow the trend. Do not rely on one laboratory reading. Two readings are needed for a trend. Bili should be trending down; hemoglobin/hematocrit increasing.Bethany: Continuity of care from MFM to neonatologist to pediatrician to pediatric hematologistTest cord blood at birth (hematocrit/hemoglobin, bilirubin, Direct Coombs Test (DCT))Providers who understand how hemolytic jaundice and hemolytic anemia work (as opposed to newborn jaundice and iron deficiency anemia)Close monitoring and aggressive treatment for hyperbilirubinemia (see AAP guidelines linked above)Follow-up blood tests weekly after hospital discharge

The Allo Podcast is back for a third season! This season features:New stories of survival in the most critical of medical situations.Conversations with MFM Dr Kara Markham and Neonatal Specialist Dr Tim Bahr.New information about medical advancements in the treatment of HDFN.A live gender reveal from one of the podcast’s previous guests.And, of course, Bethany Weathersby and Molly Sherwood are back to brighten your day.New episodes begin streaming on Tuesday November 5th. So, shine up your earbuds, get ready to be inspired and empowered, and follow the Allo Podcast wherever fine podcasts are streamed. Or, if you’re looking for some smiling faces and the occasional teary eye, join us over on YouTube.

Over the Past 2 seasons Bethany and Molly have discussed the lack of consistent, accessible treatment and the current ways we can treat an alloimmunized mom and her children with HDFN, but on this episode with Dr. Moise we discuss a bright future. Can a simple carbon monoxide reader replace a needle procedure to monitor for anemia? Can a drug stop antibodies from crossing the placenta entirely? We look to the cutting edge of medical treatment for disease that brought these women together. Guest: Dr. Kenneth J Moise Jr, M.D. Dell Medical School – UT AustinDirector, Comprehensive Fetal Care Center Dell Children’s Medical CenterDONATE TO AHF AFRICAEpisode Topics: Severity of subsequent alloimmunized pregnanciesIVIG and importance of timely treatmentIdeal newborn management of HDFNAntibody-specific differences in newborn HDFN presentationErythropoietin to prevent or delay need for neonatal transfusionCell free fetal DNA (cffDNA) (Billion To One’s Unity Screen) for fetal antigen typing instead of amniocentesisExhaled carbon monoxide to monitor for newborn anemiaNipocalimab trial updateState of alloimmunization/HDFN in AfricaWhat can you do to help?Links: Leiden paper on disease severity in subsequent alloimmunized pregnanciesPETIT trial on IVIGLeiden paper on neonatal management of HDFNErythropoietin for newborns with HDFN to delay or reduce need for transfusioncffDNA for fetal antigen statusUtah study on carbon monoxide to detect hemolysisNipocalimab for HDFN:Clinical trial listing (continuously updated)Phase 2 resultsAHF/Dr. Moise live webinar with allo moms on nipocalimabEthiopia studyWorldwide Initiative for the Eradication of Rh DiseaseRhesus Solution Initiative (Nigeria)DONATE TO AHF AFRICAGeneral donation to AHFResearch for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by Media Club.

Continuing from last episode, Bethany and Molly listen to Rose Murage’s story. As Rose navigates the final few steps to the United States, she discovers that both the lack of quality care in Kenya and the trauma of her previous pregnancies will follow her to America. But tears of sorrow become tears of joy when she is finally in the hands of a provider who can offer empathetic, quality care, and the world and the podcast welcomes baby Lucas. Episode themes: Traveling to another country to receive care for alloimmunization/HDFNSevere HDFN MCA Doppler ultrasound to monitor for fetal anemia Intrauterine blood transfusion (IUT) Emergency c-sectionNICU experience with HDFN babyWelcoming a miracle while coping with the grief of previous lossHopeWhat can you do as a listener?Please donate to the AHF Africa program. An antibody screen in Kenya costs $5, but most families cannot afford this additional expense. We need $12,000 a year to sustain this program. Learn more about what we do with your donations and make a donation here. Anyone who contributes a $50/month recurring donation will receive quarterly e-mail updates directly from Rose, AHF’s Ambassador to Kenya.Join O Negative Foundation Kenya if you live in Kenya and have a negative blood type.Follow or donate to Rhesus Solution Initiative, a Nigerian NGO dedicated to educating women about their blood type and providing access to Rh immune globulin to prevent alloimmunization.Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by https://www.mediaclub.co.

This special two-part episode of the Allo Podcast is intended for our regular listeners and for those who are unfamiliar with alloimmunization. A beautiful testament to the grace of humanity, Bethany and Molly sit on the floor of Molly’s bedroom with guest Rose Murage, a native Kenyan with a harrowing pregnancy journey. Rose shares the pain of watching her first two children die tragic, inexplicable deaths. But when Rose reached out to Bethany for help, a new journey began to diagnose Rose with red cell alloimmunization and find a way towards a living baby in a country with limited resources. Join us for the first part of Rose’s story as she tells of her life in Kenya, the short physical lives of Alexis and Max, the obstacles she overcame to seek treatment, and the gift of an American doctor and a network of activists to heal a family.Definitions for the show notes as they appear in the episode: Rhogam shot/Rh immune globulin/Anti-D injection: An injection for Rh negative women to help prevent them from developing Anti-D antibodies during pregnancy. This needs to be administered after pregnancy bleeding, at 28 weeks, and after birth. Access to this injection is limited in developing countries and often not affordable for the average family.ICT test: Indirect Coombs Test, a blood draw on the mother to see if she has red cell antibodies (alloimmunization) which can attack her baby's blood and cause HDFN. This is also called an antibody screen. DCT test: Direct Coombs Test, a blood test that is run on babies after birth to see if mom's antibodies are attaching to their blood cells. A baby with a positive DCT usually means they have hemolytic disease of the fetus and newborn (HDFN).MCA Doppler scan: Specialized ultrasounds that detect fetal anemia. This is the best way to monitor a baby at risk for HDFN to determine if they need an intrauterine blood transfusion to treat their anemia. An MCA value of 1.0 is normal, and 1.5 means the baby is anemic and needs a transfusion. In Kenya, very few hospitals can conduct these MCA Doppler ultrasounds accurately.IUT: Intrauterine transfusion, currently the only way to treat a baby with HDFN in utero. This is a blood transfusion into the baby's umbilical vein using a long needle through the mother's abdomen.Rhesus positive: This means that a person has a positive blood type (D antigen positive). Rose's body is Rhesus negative and makes antibodies to Rhesus positive (D antigen positive) blood. Any donors for her baby would need to be Rhesus negative so that her antibodies do not destroy the newly donated blood.What can you do as a listener?Please donate to the AHF Africa program. An antibody screen in Kenya costs $5, but most families cannot afford this additional expense. We need $12,000 a year to sustain this program. Learn more about what we do with your donations and make a donation here. Anyone who contributes a $50/month recurring donation will receive quarterly e-mail updates directly from Rose, AHF’s Ambassador to Kenya.Join O Negative Foundation Kenya if you live in Kenya and have a negative blood type.Follow or donate to Rhesus Solution Initiative, a Nigerian NGO dedicated to educating women about their blood type and providing access to Rh immune globulin to prevent alloimmunization.Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org.The Allo Podcast is produced and edited by Media Club.

Agne’s experience of growing up in the Soviet Union has left her with a vague medical record that doesn’t explain her severe antibody titer affecting her pregnancies. Bethany and Molly experience the culture shock of Agne’s uncommon options following the loss of her first child to a failed intrauterine blood transfusion, followed by two more unthinkable losses as she searches for the information she needs to have her rainbow baby even when it feels impossible.Show Themes: Alloimmunization and HDFN treatments in Eastern Europe Parental antigen and antibody status testing Conflicting issues between social views and medical treatment Social customs on discussing loss and pregnancy complications Experiencing the Nipocalimab trial in Belgium References:Nipocalumab trial Phase 2 resultsNipocalimab trial Phase 3 enrollment updateResearch for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org.The Allo Podcast is produced and edited by Media Club.

A powerful episode that you may not know you needed. Bethany and Molly share from the heart in this special episode that will open you up to an awareness and understanding you may not have considered before. Grief and trauma are more common than you think across the motherhood journey, but especially in pregnancies affected by alloimmunization. This episode is intended for any listener who has experienced loss related to pregnancy and motherhood, no matter how big or small, and for those who want to better support a person who has experienced pregnancy trauma and grief. Bethany and Molly share about grief from the loss of a child, and also grief from the loss of expectations, loss of trust, loss of hope for what pregnancy and motherhood would feel like. With the help of insights from previous guests, they discuss a path toward hope and healing the wounds we suffer with loss of a child, the burden of high risk pregnancy, and how to honor our losses.Show Themes:Defining trauma and grief: it’s more than pregnancy lossIdentifying the types of trauma with this diseaseHow to find support in times of needSpecific coping tips for loss and griefHow to support a person who has lost a childFinding hope in the darkest momentsLinks:Why high risk pregnancy causes traumaArticles on Losing Lucy and Finding HopeBooks on finding hope and accepting grief“A Grace Disguised” by Jerry Sittser“An Exact Replica of a Figment of my Imagination” by Elizabeth McCracken“A Grief Observed” by CS Lewis“I Will Carry You” by Angie Smith“A Path through Suffering” by Elisabeth ElliottEffectiveness of a counseling intervention after a traumatic childbirth: a randomized controlled trialIf you or a loved one are having thoughts of suicide contact your national suicide prevention hotline https://988lifeline.org/.Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org.The Allo Podcast is produced and edited by Media Club.

The onset of a strange itchiness results in the discovery that pregnant Emily Rusch is experiencing cholestasis. A lack of adequate medical attention results in the death of Emily’s baby in the NICU. Emily shares about her experience as a bereaved and newly sensitized mother as she navigates alloimmunization in her subsequent pregnancies. Show Themes: Pregnancy related itching and cholestasis Losing a child Discerning and pursuing medical malpractice litigationFinding ways of maintaining control in difficult situations Advocacy in the NICU and post-discharge for HDFN babiesAnxiety of motherhood and the burden of being your baby’s best advocate References: CholestasisHDFN Newborn calculators and toolsResearch for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by Media Club.

Bethany and Molly chat with Dr. Kara Markham, (M.D. University of Cincinnati Medical Center) a maternal fetal medicine specialist and expert in the pregnancy management of alloimmunization and HDFN. They ask questions from the allo community, and end with Bethany and Dr. Markham in a trivia competition about HDFN. During this grab bag episode, Bethany, Molly and Dr. Markham discuss the following, and more:Whether antibody titers can be loweredWhether to use Rh immune globulin ("Rhogam") in early pregnancy bleedingCross-matching for more than just the D antigen before transfusionBreastfeeding HDFN babiesChecking titers before pregnancyWhen to do plasmapheresis and IVIGWhen to conduct MCA Doppler ultrasoundsHow to ask for different careResources mentioned in this episode:AAP guidelines for hyperbilirubinemia: LINKZimmerman et al. study (with Mari) discussing the utility of weekly MCAs in discussion: LINKDr. Markham's paper on women with multiple antibodies: LINKSensitization Rates:Buhari HA, Sagir A, Akuyam SA, Erhabor O, Panti AA. Distribution of Maternal Red Cell Antibodies and the Risk of Haemolytic Disease of the Foetus and Newborn in Sokoto Nigeria. Journal of Complementary and Alternative Medical Research. 2022 Dec 23;20(2):22-9.Fan J, Lee BK, Wikman AT, Johansson S, Reilly M. Associations of Rhesus and non-Rhesus maternal red blood cell alloimmunization with stillbirth and preterm birth. International journal of epidemiology. 2014 Aug 1;43(4):1123-31.Yang EJ, Shin KH, Song D, Lee SM, Kim IS, Kim HH, Lee HJ. Prevalence of unexpected antibodies in pregnant Korean women and neonatal outcomes. The Korean Journal of Blood Transfusion. 2019 Apr 30;30(1):23-32.Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at allohopefoundation.org.The Allo Podcast is produced and edited by https://www.mediaclub.co

Amber already had a difficult and rare blood disorder (TTP) but treatment for her unknown disease resulted in her developing antibodies, resulting in alloimmunization in her first pregnancy. A chance visit with a different doctor made the difference with her first child, but extraordinary measures were needed when she became pregnant with twins. Bethany and Molly are in for quite a tale of HDFN in already unusual circumstances. Show ThemesPregnancy with secondary diseaseManaging alloimmunization with twinsWhen to get an IUTMaking difficult decisions with twins After birth in the NICU and preemie challenges LinksTTP information Platelet Disorders - Thrombotic Thrombocytopenic Purpura (TTP) | NHLBI, NIHTTP and Pregnancy TTP and pregnancy | Blood | American Society of Hematology (ashpublications.org)MoM calculator Calculators & Tools - Allo Hope FoundationIUT outcomes with hydrops Liden https://www.sciencedirect.com/science/article/abs/pii/S0002937801313728 Nystagmus Nystagmus: Definition, Causes & Treatment (clevelandclinic.org)NEC Necrotizing Enterocolitis (NEC): What is it, Causes & Treatment (clevelandclinic.org)

Navigating maternal alloimmunization and having a baby with HDFN is a high-stress, difficult, and sometimes dangerous experience. Sometimes you may want to make a choice to navigate around these difficulties. What are your options? Molly and Bethany discuss options available to Allo moms and families, and Bethany shares her own past experiences considering each option and even attempting adoption. Remember, at the end of the day, the decision is always yours. Show Themes: Making the decision to get pregnant again, natural or otherwise. The options:In-vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) Sperm donationSurrogacyAdoption Embryo adoption Making a personal decision despite outside pressure. Reference:First cases of IVF with PGD for Antigen selection:PGD for the K antigen in US, 2003: https://www.sciencedirect.com/science/article/pii/S0015028203011567PGD for the D antigen in Austria, 2005: https://academic.oup.com/humrep/article/20/3/697/2356451?login=falseInducing lactation protocol for adoptive moms. Induced lactation: Can I breastfeed my adopted baby? - Mayo ClinicThe Heart Gallery https://heartgalleryofamerica.org/More Information: IUI with sperm donation: https://americanpregnancy.org/getting-pregnant/donor-insemination/ https://www.healthline.com/health/artificial-insemination#successIVF: https://www.nhs.uk/conditions/ivf/PGD: https://www.reproductivefacts.org/news-and-publications/patient-fact-sheets-and-booklets/documents/fact-sheets-and-info-booklets/preimplantation-genetic-testing/Surrogacy: https://my.clevelandclinic.org/health/articles/23186-gestational-surrogacy#:~:text=In%20gestational%20surrogacy%2C%20the%20embryo,starts%20with%20selecting%20a%20carrier. Adoption: https://creatingafamily.org/adoption/resources/Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by Media Club

Navigating the American medical system is not new to a clinician like Katie, but experiencing it as a rare disease patient is a different story entirely. This week Bethany and Molly interview Allo Hope Foundation’s Director of Development, Katie Shanahan, a nurse practitioner who became sensitized after not receiving Rh immunoglobulin (RhIG, sometimes called RHOGAM). Her alloimmunization progressed rapidly as her son developed significant HDFN in her first alloimmunized pregnancy. Katie shares stories of IUTs and NICU life in such a relatable and informative way. Also, the women discuss the process of in vitro fertilization and how preimplantation genetic diagnosis can make Katie’s next pregnancy a very different experience. Show Themes:Low titer progressing to severe diseaseFirst alloimmunized pregnancyIUT protocols and timingNICU experience Grief and traumaReflecting on daily life after an alloimmunized pregnancyIn vitro fertilization (IVF) using preimplantation genetic diagnosis (PGD) to have an antigen negative babyReferenceStudy about missed Rhogam https://www.sciencedirect.com/science/article/pii/S2666577821000368More information about cffDNA testing through the Unity Screen https://unityscreen.com/conditions-fetal-antigens/ or Sanquin Laboratories https://www.sanquin.org/products-and-services/diagnostics/non-invasive-fetal-blood-group-genotyping Fetal outcomes are improved if IUTs are conducted before signs of hydrops https://www.sciencedirect.com/science/article/abs/pii/S0002937801313728 Use of erythropoietin (EPO) in newborns with HDFN review https://www.sciencedirect.com/science/article/abs/pii/S0378378211002337 and ongoing clinical trial https://scholarlypublications.universiteitleiden.nl/access/item%3A3284942/downloadResearch for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by Media Club

In this episode, Bethany and Molly focus on obstetricians and other medical professionals who play the critical role of diagnosis and initial treatment planning for alloimmunized patients. To close, Bethany and Molly play a game to try to treatment plan for alloimmunized patients based on limited information, and find a new level of appreciation for physicians. Show themes Telling a patient they have maternal alloimmunization: what every patient wishes they could hearMost important initial blood tests and their implicationsDetermining how quickly a patient should see a high risk doctorThe importance of finding the right MFM, not the nearest MFMReferenceACOG conference information ACOG Annual Clinical & Scientific MeetingHow to get a Allo Hope Foundation Patient Booklet Booklets - Allo Hope FoundationACOG’s list of antibodies known to cause HDFN Management of Alloimmunization During Pregnancy | ACOGMFM provider checklist Provider Checklist - Allo Hope FoundationACOG guidelines for Late Preterm/Early Term Deliveries Medically Indicated Late-Preterm and Early-Term Deliveries | ACOGResearch for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by Media Club

Welcome back to Season 2 of The Allo Podcast. Bethany and Molly return and begin the season with Brittany Pineda, an incredible mother whose antibodies were missed in her first two alloimmunized pregnancies. After suffering the loss of her son Kristian, she shares a story of hope as she stops at nothing to get the care she needed even with extremely aggressive disease. Brittany’s story demonstrates how doctors across multiple states can come together to create a comprehensive and effective treatment plan for even the most complicated situation. Show Themes: Red flags in treatmentFetal lossWhen to find second opinionsSevere HDFN (early onset)Plasmapheresis and IVIG for severe diseaseCoordination of care across multiple providersNICU experiencesIron chelation therapy in HDFN newborns with extremely high ironLinks: Study about missed Rhogam https://www.sciencedirect.com/science/article/pii/S2666577821000368MFM question checklist Provider Checklist - Allo Hope FoundationFetal outcomes are improved if IUTs are conducted before signs of hydrops https://www.sciencedirect.com/science/article/abs/pii/S0002937801313728Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by Media Club

The Allo Podcast is back for a second season! This season features:Amazing new stories of resilience, heartbreak, and survival told by the Allo moms from the US, Europe, and Africa.Conversations with top MFM's in the field including Dr. Kara Markham and Dr. Ken Moise.New information about medical advancements in the treatment of HDFN.Exclusive data from research conducted by the Allo Hope FoundationAnd, of course, Bethany Weathersby and Molly Sherwood are back to brighten your day.New episodes begin streaming on Tuesday September 12, 2023. So, shine up your earbuds, get ready to be inspired and empowered, and follow the Allo Podcast wherever fine podcasts are streamed.

Bethany and Molly discuss the history of HDFN and Alloimmunization. From the 1600s with a strange record of infant mortality to early attempts to hit an umbilical cord with a needle using only an x-ray and paper clips. They tell the story of the true state of disease management today using direct quotes from affected families. They also look to the future with hopes of new preventative medicines that could change the treatment of HDFN. Episode themes: The first reported case of HDFNRhesus monkey tests and the Rh factor Early treatments for fetal anemia William Liley’s first treatments The discovery of the middle cerebral artery (MCA) and relationship with anemia Rhesus immune globulin (RhoGAM)Using Cell Free Fetal DNA to test for Alloimmunization The prediction of a medication to block the antibody Soapbox moment: the state of this disease todayAllo Hope Terminology Library https://allohopefoundation.org/library/terminology/Guests: Dr. Ken Moise https://partnersincare.health/directory/kenneth-moiseLinks mentioned in this episode: The History of HDFN (timeline on AHF website): https://allohopefoundation.org/library/history/Mari’s article on MCA Dopplers: https://www.nejm.org/doi/full/10.1056/nejm200001063420102Dr. Moise’s editorial from New England Journal of Medicine: https://www.nejm.org/doi/full/10.1056/NEJMe068071Nipocalimab trial: https://clinicaltrials.gov/ct2/show/NCT04951622Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by https://www.mediaclub.co

Okay, we’ve had the podcast baby, now what? Molly and Bethany discuss the medical measures needed to keep the baby healthy after they join us on the other side. As our new patient is born we have a new series of information and tips to keep baby safe until baby is finally cleared of mom’s antibodies, usually by 12 weeks of age. Episode themes: Why baby is still affected by mom’s antibodies after birthTwo major effects of HDFN: hyperbilirubinemia and anemiaMonitoring bilirubin via blood test or photo sensor.Transfusions: exchange, top-up and IVIG, and tips if your baby needs oneDelayed onset anemia: why a baby with no symptoms at birth needs to be monitoredWeekly blood tests for reticulocyte count and hematocrit/hemoglobinWhen to treat anemia and hyperbilirubinemiaWhen we’re done with HDFNHDFN babies do not need iron supplements: request ferritin tests before care teams give iron supplementsSpecial considerations in babies who received intrauterine transfusions (IUTs) in uteroBaby’s pre-birth medical history is not automatically recorded in baby’s medical recordTerminology used in this episode: Bilirubin: The substance formed when red blood cells are broken down. Bilirubin is part of the bile, which is made in the liver and is stored in the gallbladder. The abnormal buildup of bilirubin causes jaundice.Exchange transfusion: A blood transfusion in which the patient's blood or components of it are exchanged with (replaced by) other blood or blood products.Hematocrit: The ratio of the volume of red blood cells to the total volume of bloodHemoglobin: A protein inside red blood cells that carries oxygen from the lungs to tissues and organs in the body and carries carbon dioxide back to the lungs.Hyperbilirubinemia: High levels of a product produced when red blood cells are broken down. In the case of alloimmunization, they are broken down by the mother’s antibodies. Excess bilirubin can cause jaundice, kernicterus, hearing loss, tooth enamel problems, permanent brain damage or even death if left untreated.Kernicterus: Bilirubin-induced permanent brain damage as a result of high levels of bilirubin, also called bilirubin encephalopathy. Signs of Kernicterus are considered a medical emergency and include: a high pitched cry, arched back, and an inconsolable infant.Reticulocyte count (Retic): This is a measure of how many immature blood cells are in the bloodstream. These are future RBCs and can give an idea of how quickly a baby is making new blood to replace what the antibodies are destroying. It can be used to decide if a top up transfusion is needed or if another check in a couple days will suffice.Top-up transfusion: Adding blood or blood products without removing any blood, these are also known as simple transfusions.Linked mentioned in this episode: AAP hyperbilirubinemia guidelines: https://www.aap.org/en/patient-care/hyperbilirubinemia/AAP treatment chart for hyperbilirubinemia in HDFN babies (also available within the overall guidelines linked above): https://publications.aap.org/view-large/figure/10539368/PEDS_2022058859_f3.tifGet free HDFN Prenatal and Postnatal information booklets: https://allohopefoundation.org/library/booklets/Untreated hyperbilirubinemia leads to kernicterus in 25% of cases, see HDFN review of current trends and treatments:https://pubmed.ncbi.nlm.nih.gov/34675752/Post-birth guidelines from Netherlands: Smits-Wintjens, V. E. H. J. (2012, February 15). Neonatal management and outcome in red cell alloimmunization.https://scholarlypublications.universiteitleiden.nl/access/item%3A2894186/viewAllo Hope Terminology Library https://allohopefoundation.org/library/terminology/For more on tests during pregnancy, see our prenatal testing guide at https://allohopefoundation.org/library/prenatal-testing/Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by https://www.mediaclub.co

Eventually, a pregnancy story becomes a birth story. Molly and Bethany cover the various things to expect with an Alloimmunized birth, and talk about the many things you can do to prepare for your birth, and some choices you can make to have your birth experience be your own. Episode themes:Delivery timing and how IUTs affect your delivery timeWhy home births are not indicatedWhat to look for in a NICUWhat tests to request at deliveryRequesting crossmatched blood, just in case Maintaining your empowerment Creating a birth plan What to pack for your deliveryHow to give birth. No, really. Terminology:Direct Antiglobulin Test (DAT): This test looks for antibodies that are bound to red blood cells and is typically done on infants. With specific antibodies, this test can be negative even when the baby is still affected and needing treatment. Bilirubin (Bili): A product created when red blood cells are broken down. In the case of alloimmunization, they are broken down by the mother’s antibodies. Excess bilirubin can cause jaundice, kernicterus, hearing loss, tooth enamel problems, permanent brain damage or even death if left untreated.Complete Blood Count (CBC): This is a laboratory test that checks the levels of a variety of blood cells and includes hemoglobin, hematocrit, neutrophil count, reticulocyte count, and more.Allo Hope Terminology Library https://allohopefoundation.org/library/terminology/Guests: Dr. Thomas Trevett http://www.georgiaperinatal.com/dr-trevett/Links mentioned in this episode: ACOG Medically Indicated Late-Preterm and Early-Term Deliveries (guideline on delivery timing): https://www.acog.org/clinical/clinical-guidance/committee-opinion/articles/2021/07/medically-indicated-late-preterm-and-early-term-deliveriesFreya Positive Birthing App: https://thepositivebirthcompany.co.uk/freya-hypnobirthing-appRequest a patient booklet: https://allohopefoundation.org/library/booklets/Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org/The Allo Podcast is produced and edited by https://www.mediaclub.co/

Most episodes of the Allo Hope Podcast discuss the effects of alloimmunization on mom and baby, but on this episode we talk to partners. Bethany and Monique interview eachother’s partners and discover how they found out, what they felt, and how they supported their wives and children during the difficult pregnancies. Visit Bethany and Monique’s individual story episodes to learn more about their alloimmunization journey.Episode themes: The discovery of a partner’s struggle How to advocate for your partner and baby’s care Dealing with loss and what it means for your partner, family, and future Searching for stability in a time of unexpected issues Options for dad What to do in the NICUAllo Hope Terminology Library https://allohopefoundation.org/library/terminology/Guests: David Kinney and Josh Weathersby Research for this episode provided by Bethany Weathersby and Monique Kinney of the Allo Hope Foundation. Find more information at https://allohopefoundation.org/The Allo Podcast is produced and edited by https://www.mediaclub.co/

In our quest to share the experience of Alloimmunized moms, Bethany interviewed Monique Kinney, a contributor to the Allo Hope Foundation. Monique founded the premier Facebook support group for Alloimmunized moms before the Allo Hope Foundation was started in 2019. Episode themes: Monique’s proactive discovery of her Anti-E antibody statusThe Bad NumberAdvice for post-birthMid-Pregnancy Postpartum AnxietyAdvocacy against hospital policyBeing your baby’s medical recordTerminology used in this episode: Antibody Evanescence: The waning of antibodies over time following an exposure to the immunized antigen. Once a patient develops antibodies, the antibodies never truly disappear. Fewer than 30% of antibodies are estimated to be detectable by current methods.Antibody Boostering: When an antibody undetectable during cross-matching is suddenly detectable again. Antibody boostering happens in patients who were earlier found to have alloantibodies, but then experienced antibody evanescence. Boostering can result in the antibodies coming back in an anamnestic manner, including hyperhemolysis.Allo Hope Terminology Library https://allohopefoundation.org/library/terminology/Guests: Monique Kinney Links mentioned in this episode: Facebook support group: https://www.facebook.com/groups/antibodiesinpregnancyMari et al. paper discussing 12% false positive rate for MCA scans: https://www.nejm.org/doi/full/10.1056/nejm200001063420102Research for this episode provided by Bethany Weathersby, Molly Sherwood, and Monique Kinney of the Allo Hope Foundation. Find more information at https://allohopefoundation.org/The Allo Podcast is produced and edited by https://www.mediaclub.co/

Why do we have to advocate so hard for adequate care for Maternal Alloimmunization? This disease is so rare, many maternal fetal medicine doctors (MFMs) simply do not treat it often. Finding the right doctor with experience in this disease can change the outcome of your pregnancy experience and the health of your baby. Episode topics: Common barriers to good careDoctor’s reflection on the patient/provider relationshipUnderstanding your choices with an MFM Establishing mutual trust with your Doctor What to look for in an MFMYour body, your baby, your careThe things to look out for in a doctor Green Flags:Doctor offers cell free fetal DNA tests if appropriateDoctor discusses all appropriate treatment options with you in a collaborative wayPlanning for possibilities of IUTsDoctor increases their own education on alloimmunization if neededDoctor follows up after birth Provides ultrasound 24 hours after IUT Gives paralytic to baby in IUTIUT in an operating roomDoctor communicates with post birth care providers Cares about your emotional and mental well being For a full list developed and approved by our Patient and Medical advisory boards, check out AHF’s Excellent Care Checklist: https://allohopefoundation.org/wp-content/uploads/2022/10/Alloimmunization-HDFN-Excellent-Care-Checklist.pdfBethany’s questions for Dr. Trevett (*note, this is an example that is relevant specifically to Bethany’s pregnancy. Your questions may be different depending on your disease and access to care):Are you willing to collaborate with other doctors if needed for my care throughout my pregnancy?Are you on board with this treatment plan?Permacath surgery at 8 or 9 weeksPlasmapheresis and IVIG at 9 or 10 weeksWeekly IVIG infusions until baby's first IUTcffDNA test for baby's antigen status at 14 weeksweekly MCA Doppler scans starting by 15 weeks 3. How comfortable are you with the IUT procedure? 4. How many IUTs do you usually perform per year? 5. What is your success rate? 6. What is the earliest IUT you have ever performed? 7. Walk me through your IUT procedure. 8. Do you use IPT, IVT or a combination of both for your IUTs? 9. Do you perform IUTs in an operating room? 10. Do you sedate and paralyze the baby during an IUT? 11. Do you provide IV sedation for the mother during an IUT? 12. What kind of monitoring do you provide after an IUT? 13. Do you scan the baby 24 hours after every IUT? 14. What gestation do you consider viable? 15. When do you administer steroids to the baby? 16. Do you usually give Phenobarbital to mother leading up to delivery for liver development? 17. Who handles my normal OB care? You or an OBGYN? Who delivers? 18. When do you usually do the last IUT? 19. When do you usually want patients to deliver? 20. How many alloimmunized patients do you usually see per year? 21. Does your hospital have a level 4 NICU? 22. Do you think my next baby would survive? Have the same chance of survival as my previous allo pregnancies? 23. Is there a Ronald McDonald House nearby?Allo Hope Terminology Library https://allohopefoundation.org/library/terminology/Guests: Dr. Ken Moise https://partnersincare.health/directory/kenneth-moiseDr. Thomas Travett http://www.georgiaperinatal.com/dr-trevett/Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org/The Allo Podcast is produced and edited by https://www.mediaclub.co/

Bethany’s story continues with the growth of her family, learning from the mistakes made in Lucy’s treatment for severe HDFN. After Bethany becomes pregnant she goes to great lengths to keep her babies safe, moving out of state, undergoing frequent plasmapheresis and IVIG, many IUTs, NICU time, and post-birth transfusions. While Bethany’s proactive pursuit of treatment leads to the delivery of 3 healthy children, the loss of Lucy motivates her toward activism and the founding of the Allo Hope Foundation. Episode themes: Educating yourself Finding an excellent doctorPursuing other family options (sperm donation, adoption, preventative treatment) Preventative treatments for severe HDFNThe Rainbow BabyMaking the decision to continueUnexpected deliveries One more timeThe Blog: Losing Lucy and Finding HopeThe Allo Hope Foundation Terminology used in this episode: Cell-Free Fetal DNA (cffDNA): This noninvasive test uses the fetal DNA that is found floating in maternal circulation to check the fetal red cell antigen status. It requires a blood sample from the mother. cffDNA can be used for pregnancies complicated by anti-Kell, anti-D, anti-C, anti-c, anti-E, and anti-e antibodies.Intravenous Immunoglobulin (IVIG): An infusion of mostly IgG immunoglobulins that is made by extracting the immunoglobulins from the plasma of ~1,000 donors. It is thought to lessen the mother’s antibody response and delay fetal anemia. It can also be given after birth to newborns to treat hyperbilirubinemia. It may affect the efficacy of live virus vaccines for up to a year after administration.Plasmapheresis: A procedure where the blood is removed from the mother, the antibody-rich plasma is removed, and blood cells are returned. This can decrease the antibody titer.Allo Hope Terminology Library https://allohopefoundation.org/library/terminology/Links mentioned in this episode: Losing Lucy and Finding Hope blog: https://losinglucyandfindinghope.com/HDFN Newborn Care Booklet: https://allohopefoundation.org/wp-content/uploads/2022/08/AHF-Newborn-Booklet.pdfPrenatal decision tree https://allohopefoundation.org/library/prenatal-tree/Post birth testing https://allohopefoundation.org/library/infant-testing/Provider letter: https://allohopefoundation.org/wp-content/uploads/2022/08/Letter-to-Providers-Final.docxResearch for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by https://www.mediaclub.co

Host and Allo Hope Foundation founder Bethany Weathersby tells the story of Lucy, her daughter, who passed from HDFN. Her loss sparked the blog Losing Lucy and Finding Hope, which grew into a resource for alloimmunized mothers seeking help and support. Lucy’s loss gave Bethany the drive to advocate for alloimmunized moms and HDFN babies around the world, and to advocate for the lives of her future children (more on that in Part 2). Lucy’s life has continued to impact the lives of countless babies with HDFN.Note that since the time of this recording, Allo Hope Foundation has changed its recommendation such that a critical titer for Kell is any titer (previously 4), consistent with the ACOG Practice Bulletin, available here: https://pubmed.ncbi.nlm.nih.gov/29470342/Episode themes: Diagnosis of alloimmunizationFamily life during an alloimmunized pregnancyThe life saving power of advocacySevere, early HDFNFetal death, stillbirth and griefTerminology used in this episode: PSV: the measurement gained from the MCA Doppler ultrasound. It is the maximum velocity (sometimes called Pmax) that blood is moving through the middle cerebral artery. Anemic blood flows faster than nonanemic blood. The PSV is used to calculate the Multiples of the Median (MoM) value to check for anemia.MoM: The result of the calculation to see if the baby is anemic. The peak systolic velocity (PSV) and gestational age are used to calculate the MoM. A result of 1.3 indicates mild anemia. Numbers of 1.5 or higher indicate moderate to severe anemia and signals the need for an intrauterine transfusion or delivery. Lucy’s was 2.5Allo Hope Terminology Library https://allohopefoundation.org/library/terminology/Links in this episode: https://losinglucyandfindinghope.com/Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.orgThe Allo Podcast is produced and edited by https://www.mediaclub.co

Severe alloimmunization is surrounded by vague information and confusion, but this episode will prepare patients and providers for available treatment. Patients with previous fetal death, previous IUT before 24 weeks, or with a titer of 256 or higher may be diagnosed with severe disease. Remember, options do exist for severe situations, and prevention and monitoring are the key elements to having a healthy baby. This episode discusses IVIG and plasmapheresis, early MCA Scans and early IUTs, and phenobarbital. Episode themes: Common misconceptions about severe diseaseDefining severe diseaseDelaying IUTs with IVIG and plasmapheresis treatmentWhat to expect during IVIG and plasmapheresisOral phenobarbital for mom to reduce need for newborn transfusion after birthTips for patients entering a pregnancy complicated by severe diseaseIVIG: Intravenous Immunoglobulin: An infusion of mostly IgG immunoglobulins that is made by extracting the immunoglobulins from the plasma of ~1,000 donors. It is thought to lessen the mother’s antibody response and delay fetal anemia. It can also be given after birth to newborns to treat hyperbilirubinemia. Phenobarbital: An oral medication given to an alloimmunized mother before baby’s birth to improve baby’s liver function, allowing the baby to more efficiently break down bilirubin and reducing the need for exchange transfusion after birth.Plasmapheresis: The process of removing the plasma from the body whereby the blood is removed and run through a machine that separates the plasma from the red blood cells. The plasma is discarded and the red blood cells are returned to the body with fewer antibodies (which live in plasma).Allo Hope Terminology Library https://allohopefoundation.org/library/terminology/Guests: Dr. Ken Moise https://partnersincare.health/directory/kenneth-moiseDr. Thomas Travett http://www.georgiaperinatal.com/dr-trevett/Links mentioned in this episode: PETIT study on IVIG:l https://pubmed.ncbi.nlm.nih.gov/29902448/Ruma et al. on plasmapheresis & IVIG: https://www.sciencedirect.com/science/article/abs/pii/S0002937806022058Trevett et al. on phenobarbital: https://www.ajog.org/article/S0002-9378(04)00938-X/fulltextJansen nipocalimab clinical trials for severe disease patients: https://clinicaltrials.gov/ct2/show/NCT03755128https://clinicaltrials.gov/ct2/show/NCT03842189Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org.The Allo Podcast is produced and edited by https://www.mediaclub.co.

Molly and Bethany discuss the when and how of intrauterine blood transfusions (IUTs). Bethany, possibly the world record holder for number of IUTs, has had 16 IUTs through her four allo affected pregnancies. IUTs come with their own risks, but in the hand of a trained and experienced doctor they are the most effective way to maintain the health of an anemic baby.Episode themes: Likelihood of needing an IUTWhen to perform an IUT (before hydrops is present)IUT procedure before, during and afterMedications used during an IUTSpacing of IUTs when multiple are requiredOutcomes of IUTs in a skilled facilityTips for patients and cliniciansQuestions for your MFM discussed in this episode: How many IUTs do you do per year?How often do you do them?How many did you do last year?What is your success rate?Have you ever lost a baby to the procedure?How many?Do you perform the IUT in an operating room?Do you provide mom with conscious sedation?Do you paralyze the baby for the IUT?Walk me through the procedureWhat does the monitoring look like after the IUT is finished?What do you use to decide when to space IUT?When do you do the last one in general?How early have you done them?Are you willing to refer me to a different MFM for IUTs if necessary? Other TipsHave a friend or partner there with you when you get an IUT. Communicate constantly with your nurses, doctors, and anesthesiologist Communicate needs and anxietiesSpeak up about your needs and comfort Ask for and record the beginning and ending hematocrit Allo Hope Terminology Library https://allohopefoundation.org/library/terminology/IUT: Intrauterine transfusion: using a needle through the mom’s belly to insert blood into the umbilical cord or abdomen of an anemic fetus. Cordocentesis: a test done during the IUT process that determines that a fetus is definitely anemic before transfusing blood. Ascites: fluid collecting in the abdomen of a fetus, a sign of fetal hydrops. This is a sign of critical distress and blood should not be infused into the abdomen. IVT: Intravascular transfer: an IUT where the blood is transferred into the umbilical cord vein and therefore directly into the baby’s vascular system, treating the anemia right away. IPT: intraperitoneal transfusion: transferring blood into the abdomen of a baby. Usually reserved for early gestation before an IVT is possible. Blood is later absorbed into the system when the baby needs it. Not to be done when baby shows signs of fetal hydrops. Guests: Dr. Ken Moise https://partnersincare.health/directory/kenneth-moiseDr. Thomas Travett http://www.georgiaperinatal.com/dr-trevett/Links mentioned in this episode: Canada Study on how often alloimmunized women need IUTs: https://onlinelibrary.wiley.com/doi/pdf/10.1111/trf.16061?casa_token=oeYAk0MeFNsAAAAA:LxM4QAUDqnTuadhT6Ya7gZrtZ5pMv1GzwtLdJGxIHOOglSCgdN-GzjhNfMXv7EwklB1q8n9-d4sT5iEDr. Moise’s article on UpToDate: https://www.uptodate.com/contents/intrauterine-fetal-transfusion-of-red-cells?search=interueteran%20transfusion&source=search_result&selectedTitle=6~150&usage_type=default&display_rank=6Leiden retrospective analysis after 1678 IUT procedures: https://obgyn.onlinelibrary.wiley.com/share/MB8MU3HPWYVXSCUMIE7G?target=10.1002/uog.17319Study on steroids affecting MCA scans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411792/Redheads need more anesthesia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1362956/Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org.The Allo Podcast is produced and edited by https://www.mediaclub.co.

Bethany and Molly discuss how to monitor an Alloimmunized pregnancy. This is the first step to treating a sensitized pregnancy. Monitoring the antibody titer can indicate when you need MCA Scans, and intrauterine blood transfusions to keep your baby healthy. Episode themes: How babies at risk for HDFN are monitoredTiters (purpose and frequency) MCA Scans and MoM values (purpose and frequency)Specific MCA Scan tipsWhat’s next after a high MCA scanFetal outcomes and survival rates Terminology used in this episode: Antibody Titer: A measure of antibodies in the mom’s blood, indicates threat to a baby who is affected. Antigen negative babies do not need titer monitoring. Critical Titer: A titer level of 16 (or 4 for Kell) that indicates a need for in utero medical treatments. Remember, once you hit critical levels in a pregnancy you are considered always critical for each subsequent pregnancy and should start MCA scans at 15 weeks in that and each subsequent pregnancy. MCA Scan: (Middle Cerebral Artery Doppler Scan) Special ultrasound often only used after a critical titer is detected. Scans the blood flow in the middle cerebral artery of the fetus. MoM: (Multiple of the Median score) the final measurement of an MCA scan divided by gestational age of fetus. Scores of 1 are ideal, scores of 1.5 or higher indicate moderate to severe anemia and a need for intervention.Hematocrit: a score detected during a cordocentesis (blood drawn from the cord) to determine the red blood cell volume in the blood. The normal hematocrit range for infants 0-6 months is 37.4 - 55.9% for females, and 43.4 - 56.1% for males. A fetal hematocrit of less than 30% is considered anemia. Cordocentesis tests can start at 15 weeks. Anti-E Pregnancy Study: Moran P, Robson SC, Reid MM. Anti‐E in pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology. 2000 Nov;107(11):1436-8. LINKSurvival rates for fetuses receiving IUTs: Lee L, Nasser J. Doppler ultrasound assessment of fetal anaemia in an alloimmunised pregnancy. Australasian Journal of Ultrasound in Medicine. 2010 Nov;13(4):24. LINKAllo Hope Terminology Library https://allohopefoundation.org/library/terminology/For more on tests during pregnancy, see our prenatal testing guide at https://allohopefoundation.org/library/prenatal-testing/Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org.The Allo Podcast is produced and edited by https://www.mediaclub.co.