Vital HDFN Treatments & Cutting Edge Research with Dr. Ken Moise
Can a simple carbon monoxide reader replace a needle procedure to monitor for anemia? Can a drug stop antibodies from crossing the placenta entirely? We look to the cutting edge of medical treatment for disease that brought these women together.
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Show Notes
Over the Past 2 seasons Bethany and Molly have discussed the lack of consistent, accessible treatment and the current ways we can treat an alloimmunized mom and her children with HDFN, but on this episode with Dr. Moise we discuss a bright future. Can a simple carbon monoxide reader replace a needle procedure to monitor for anemia? Can a drug stop antibodies from crossing the placenta entirely? We look to the cutting edge of medical treatment for disease that brought these women together.
Guest: Dr. Kenneth J Moise Jr, M.D. Dell Medical School – UT Austin
Director, Comprehensive Fetal Care Center Dell Children’s Medical Center
Episode Topics:
- Severity of subsequent alloimmunized pregnancies
- IVIG and importance of timely treatment
- Ideal newborn management of HDFN
- Antibody-specific differences in newborn HDFN presentation
- Erythropoietin to prevent or delay need for neonatal transfusion
- Cell free fetal DNA (cffDNA) (Billion To One’s Unity Screen) for fetal antigen typing instead of amniocentesis
- Exhaled carbon monoxide to monitor for newborn anemia
- Nipocalimab trial update
- State of alloimmunization/HDFN in Africa
- What can you do to help?
Links:
- Leiden paper on disease severity in subsequent alloimmunized pregnancies
- PETIT trial on IVIG
- Leiden paper on neonatal management of HDFN
- Erythropoietin for newborns with HDFN to delay or reduce need for transfusion
- cffDNA for fetal antigen status
- Utah study on carbon monoxide to detect hemolysis
- Nipocalimab for HDFN:
- Ethiopia study
- Worldwide Initiative for the Eradication of Rh Disease
- Rhesus Solution Initiative (Nigeria)
- DONATE TO AHF AFRICA
- General donation to AHF
Research for this episode provided by Bethany Weathersby and Molly Sherwood of the Allo Hope Foundation. Find more information at https://allohopefoundation.org
The Allo Podcast is produced and edited by Media Club.