Pharmacy to Dose: The Critical Care Podcast

Rapid Reaction: PROCOAG trial Special Guest: Scott Dietrich, PharmD, BCCCP Rapid reaction episode discussing the PROCOAG study looking at 4-factor prothrombin complex concentrate (PCC) use in trauma patients at risk of massive transfusion published in JAMA. We go into the outcomes, European v. American trauma management, PCC dosing, effect of viscoelastic testing, and much more. PROCOAG trial: https://pubmed.ncbi.nlm.nih.gov/36942533/ Reference List: https://pharmacytodose.files.wordpress.com/2023/04/procoag-rapid-reaction-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: CAPE COD trial Special Guest: Carolyn Magee Bell, PharmD, BCCCP, FCCM Rapid reaction episode covering the CAPE COD trial which looked at the use of hydrocortisone in ICU CAP patients published in NEJM. We discuss outcomes, pertinent findings, questions remaining, ultimate take-aways, fun facts, and much more. CAPE COD trial: https://pubmed.ncbi.nlm.nih.gov/36942789/ Reference List: https://pharmacytodose.files.wordpress.com/2023/04/cape-cod-rapid-reaction-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Emergency Medicine Clinical Pearls and EMPoweRx Conference Special Guest: Megan Rech, PharmD, MS, BCCCP, FCCM, FCCP https://empowerx-conference.com https://rutgers.cloud-cme.com/course/courseoverview?P=0&EID=17157&formid=2931 https://empharmnet.org/ 03:35 – EMPoweRx Conference 12:28 – TXA in Epistaxis 21:40 – DDAVP in Antiplatelet-Associated ICH 34:47 – Awareness with Paralysis Reference List: https://pharmacytodose.files.wordpress.com/2023/03/em-pearls-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Heart Failure: Part II Special Guest: Cait Kulig, PharmD https://cards.rxexplained.com/ 07:55 – Transitions of Care 17:35 – HFrEF GDMT 48:35 – HFpEF GDMT Reference List: https://pharmacytodose.files.wordpress.com/2023/03/heart-failure-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Jan 2023 Special Guest: Austin Roe, PharmD 04:15 – Featured Articles 40:18 – Cardiovascular 53:05 – Neurology 57:45 – Infectious Diseases 71:12 – PharmD Reference List: https://pharmacytodose.files.wordpress.com/2023/01/lrs-dec-2022-references.pdf Full article list: https://docs.google.com/document/d/1ZDGStSjlCWg8eCCCrIHQlChyI2Y5Jrwr8cRNYIzFeIc/edit?usp=sharing PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: ANNEXA-4 Special Guest: Brian Gilbert, PharmD, MBA, BCCCP, BCPS, FCCM Discussion about the ANNEXA-4 final study results including some of our biggest takeaways, future directions, and more. ANNEXA-4: https://pubmed.ncbi.nlm.nih.gov/36802876/ Reference List: https://pharmacytodose.files.wordpress.com/2023/03/annexa-4-rapid-reaction-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Heart Failure: Part I Special Guest: Cait Kulig, PharmD https://cards.rxexplained.com/ 06:15 – Definitions 13:48 – ADHF 29:50 – Diuresis and Diuretic Resistance 52:45 – IV Vasoactives Reference List: https://pharmacytodose.files.wordpress.com/2023/03/heart-failure-part-i-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Top Cardiology Trials with Cardioscripts Special Guests: Tracy Macaulay, PharmD, BCCP, FACC, FCCP @SchwietTMax Elisabeth Wang, PharmD, BCCP @Val_Smartan Nathan Wayne, PharmD, BCPS, BCCP @TweetlessNathan 13:45 – Top Landmark Trials 32:50 – Top New Trials 50:00 – Top Grab Bag/Random Trials Reference list: https://pharmacytodose.files.wordpress.com/2023/03/top-cardiology-trials-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 SCCM PharmD Star Researchers 03:10 – Restrictive Resuscitation in Patients with Sepsis: A Systematic Review with Trial Sequential analysis with Sylvia Stefanos, PharmD 10:50 – Incidence of Acute Kidney Injury in Traumatic Brain Injury Patients Treated with Hypertonic Saline with Jesse Briscoe, PharmD 19:42 – Comparison of Factor Products for Uncontrolled Bleeding Related to Cardiac Surgery with Lauren Caldwell, PharmD, BCCCP 28:00 – Validation of Heparin-Induced Thrombocytopenia Risk Stratification Tools in Post-Surgical Cardiovascular Patients with Shahristan Kokoy, PharmD, BCPS 39:16 – Naloxone Co-prescribing for Emergency Medicine and Trauma Patients at High-risk for Opioid Overdose with William Peppard, PharmD, BCPS, FCCM 52:20 – Incidence of Detectable Drug Levels with Inhaled Aminoglycoside Therapy in Critically Ill Adults with Jenny Schultheis, PharmD, BCPS, BCCCP 63:28 – Evaluation of Achieving Targeted Vancomycin Levels in Augmented Renal Clearance with Sydney Wilson, PharmD 73:30 – Vancomycin and Piperacillin/tazobactam or Cefepime and Sepsis-Associated AKI Trajectory with Michael Behal, PharmD, BCCCP PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 SCCM PharmD Speakers Part II 02:18 – Acute Ischemic Stroke Mgmt Updates with Salia Farrokh, PharmD, BCCCP, FNCS 13:30 – Ketamine’s Role in Opioid-Sparing Analgesia with Luma Succar, PharmD, BCCCP 24:00 – Incorporating Lidocaine in Multimodal Pain Regimens with Chelsea Lopez, PharmD, BCCCP 43:19 – Choice of Analgesic/Sedatives in ABCDEF bundle with Joanna Stollings, PharmD, FCCP, FCCM, BCPS, BCCCP 58:54 – Constipation in the Critically Ill with Melissa Santibañez, PharmD, BCCCP 74:40 – Practical Aspects of Immunotherapy in the ICU Heather May, PharmD, FCCM, BCPS, BCCCP 92:27 – Updates on CAR-T Products and Toxicity Management with Anne Rain Brown, PharmD, BCCCP, FCCM 103:37 – Immunomodulator Drug Highlights with Tuqa Alkhateeb, PharmD, PhD 118:18 - Empiric Anerobic Antibiotics in the ICU with Kevin Betthauser, PharmD, BCCCP 134:37 – Pharmacotherapy Adjustments in Obesity with Bethany Shoulders, PharmD, BCCCP PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 SCCM PharmD Speakers Part I 03:46 – PAH Pharmacotherapy with Diana Lemieux, PharmD, BCCCP 17:01 – USA v. EU AF Mgmt. with Cait Kulig, PharmD 30:25 – Caring for Special Populations in the ED with Erin Wieruszewski, PharmD, BCCCP 42:26 – Medical Treatments to Consider with RV Failure in VV ECMO with Patrick Wieruszewski, PharmD, BCCCP 57:30 – Toxicology Year in Review with Rachel Wein, PharmD, BCPS 65:40 – Effect of IV Fluids on Microcirculation with Susan Smith, PharmD, BCPS, BCCCP, FCCM 75:15 – Finding Fluid Stewardship in the ICU & Phases of Fluid Management in the ICU with Anthony Hawkins, PharmD, FCCM PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Recap of 2023 SCCM Congress Special guest: W. Anthony Hawkins, PharmD, FCCM, BCCCP SF review, unique sessions, speaker perspective, FCCM/awards, Dr. Glaucomflocken, late-breaking studies, exhibit hall, receptions, our favorite sessions and more. PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Dec 2022 00:26 – Life/podcast update; 08:40 – Top 5; 24:50 – BP management; 28:55 – IV fluids; 31:40 – Lost in my mind; 39:28 – Front of the fridge Reference List: https://pharmacytodose.files.wordpress.com/2023/01/lrs-dec-2022-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Apr 2022 Special Guests: Philip Jacobson, PharmD and Andi Ray, PharmD 07:10 – 6-pack of studies; 45:20 – Don’t go breaking my heart; 55:20 – Ventilator blues; 65:00 – Front of the fridge Pt I and II Reference List: https://pharmacytodose.files.wordpress.com/2022/10/lrs-apr-2022-references.pdf Full Article List: https://docs.google.com/document/d/1EcldymfgaszAcKmYlr6wYt4XRI5_GFhQo4DeqrGAfAE/edit?usp=sharing PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Mar 2022 Special Guests: Paige Miller, PharmD and Jontae Warren, PharmD 05:00 – 6-pack of studies; 45:00 – Lost in my mind; 55:20 – When we were young; 66:50 – Don’t go breaking my heart; 79:40 – Front of the fridge Reference List: https://pharmacytodose.files.wordpress.com/2022/09/lrs-mar-2022-references.pdf Full Article List: https://docs.google.com/document/d/1X43sqQX9IYRKJ2hGSp5gneqzL0OQcxeGJMGgKs2Bu54/edit?usp=sharing PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

PCCs for PharmDs Part II Special Guest: Scott Dietrich, PharmD, BCCCP @PCC_PharmD Reference List: https://pharmacytodose.files.wordpress.com/2022/08/pccs-for-pharmds-part-ii-references.pdf 04:45 – Fixed dose PCC; 11:58 – Time to administration; 15:00 – 3-factor v. 4-factor PCC; 19:12 – 4-factor PCC v. 4-factor aPCC; 30:36 – No anticoagulation reversal; 33:36 – PCC in surgery; 37:40 – PCC in trauma; 40:51 – PCC v. andexanet alfa; 54:10 – Guideline recommendations; 62:00 – Future studies; 69:10 – Take home points PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Things We Wish We Knew During Residency Special Guests: ACCP Critical Care PRN Officers Leslie Hamilton, PharmD, FCCP, FCCM, FNCS, BCPS, BCCCP; Mojdeh Heavner, PharmD, BCPS, BCCCP, FCCM; Susan Smith, PharmD, BCCCP, BCPS 03:25 – ACCP Critical Care PRN discussion 28:35 – Residency roundtable PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Feb 2022 Special Guests: Aaron Hunsaker, PharmD and Kelsey Rhoten, PharmD 05:41 – 6-pack of studies; 46:09 – Dust in the wind; 55:20 – Under pressure; 65:04 – Lost in my mind; 74:54 – Front of the fridge Reference List: https://pharmacytodose.files.wordpress.com/2022/06/lrs-feb-2022-references.pdf Full Article List: https://docs.google.com/document/d/18g5UqJqMGvm_q9qfTiEuETV34TMaWRWbQbKzfi_vbDA/edit?usp=sharing PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Jan 2022 Special Guests: Michael Behal, PharmD and CJ Wilson, PharmD 08:13 – 6-pack of studies; 60:20 – Every breath you take; 68:35 – Under pressure; 76:43 – Lost in my mind; 84:10 – Front of the fridge Reference List: https://pharmacytodose.files.wordpress.com/2022/06/lrs-jan-2022-references.pdf Full Article List: https://docs.google.com/document/d/1Z2FDNWO6uhJjYINdnTn_ruBJHOT9s-etPyNFYmJokD0/edit?usp=sharing PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Nov/Dec 2021 Special Guests: Callee Brooks, PharmD and Andy Jatis, PharmD 05:00 – 6-pack of studies; 48:25 – Ventilator blues; 60:10 – Lost in my mind; 72:38 – Don’t go breaking my heart; 81:42 – Front of the fridge Reference List: https://pharmacytodose.files.wordpress.com/2022/05/nov_dec-2021-references.pdf Full Article List: https://docs.google.com/document/d/1E-inQwnlcNqkvq6q657UdFEZ4x9Zd_Bi_ii0iOALS3Q/edit?usp=sharing PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Management of Beta Blocker and Calcium Channel Overdose Special Guest: James Leonard, PharmD, DABAT @leonardjbrx Reference List: https://pharmacytodose.files.wordpress.com/2022/04/bb-and-ccb-overdose-references.pdf Topics covered: Activated charcoal, Hemodynamics, Calcium, High dose insulin, Lipid emulsion therapy, Glucagon, Pharmacotherapy for refractory cases, Advanced therapies “What would really happen: Medicine in the movies” Old School Knives Out Wedding Crashers PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

I wanted to talk to the Friends of the Pod about what's been going on behind the scenes and what to expect in the future. PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2021 Surviving Sepsis Campaign Guideline Updates Special Guests: Carolyn Bell PharmD, BCCCP and Brittany Bissell, PharmD, PhD, BCCCP, FCCM Reference List: https://pharmacytodose.files.wordpress.com/2022/02/2021-sepsis-guideline-updates-references.pdf 05:00 – General thoughts and historical perspective; 12:10 – qSOFA; 14:44 – Author diversity; 19:10 – IV fluids; 27:15 – Vasopressors; 33:12 – Antibiotics (and antifungals); 46:10 – Adjunctive treatments; 57:40 – Hopes for future guidelines; 61:35 – Gender inequity and sexual harassment in pharmacy PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Sept/Oct 2021 Special Guests: Sara Groome, PharmD, BCIDP and Alyssa Sykuta, PharmD, BCCCP Reference List: https://pharmacytodose.files.wordpress.com/2022/02/sept_oct-2021-references.pdf 06:10 – Sepsis 6-pack; 47:55 – In my blood; 59:55 – Ventilator blues; 72:00 – Review Room; 82:38 – Front of the Fridge PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series July/August 2021 Special Guests: Hannah Brokmeier, PharmD and Natalie Haddad, PharmD Reference List: https://pharmacytodose.files.wordpress.com/2022/01/july_aug-2021-references.pdf 06:45 – 6-pack of studies; 46:20 – Ventilator blues; 57:30 – Don’t go breaking my heart; 68:30 – Front of the fridge PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Vasoactives in Septic Shock Part II Special Guest: Patrick M. Wieruszewski, Pharm.D., BCCCP Reference List: https://pharmacytodose.files.wordpress.com/2021/12/vasoactives-in-septic-shock-ii-references.pdf 02:51 – Background into vasodilatory shock and its outcomes; 04:14 – Signs/symptoms of septic shock; 05:09 – Norepinephrine as first-line vasopressor; 09:05 – Using second-line vasopressors; 17:04 – Human physiology and hemodynamics; 21:02 – More important: time to treatment or vasopressor choice; 22:16 – Taking biomarkers/genetic markers from the research lab to clinical practice; 28:22 – Vasopressin use in septic shock; 43:14 – Angiotensin II updates; 66:00 – Epinephrine in septic shock; 69:32 – Vasopressor stewardship; 72:40 – One wish for septic shock management PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Introduction to Mechanical Ventilation Special Guests: Andrea Sikora Newsome, PharmD, BCPS, BCCCP, FCCM Reference List: https://pharmacytodose.files.wordpress.com/2021/11/mechanical-ventilation-references.pdf 05:49 – Indications for mechanical ventilation; 12:45 – Principles of critical care; 16:40 – Review of respiratory cycle; 20:04 – Common terminology (Tidal volume, FiO2, PEEP); 32:01 – Ventilator modes; 39:15 – Pressure v. volume control; 47:00 – Inspiratory pressure, plateau pressure, and autoPEEP; 51:50 – Ventilator weaning; 61:00 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series May/June 2021 Special Guests: Nikko Bonavoglia, PharmD and Alyssa White, PharmD Reference List: https://pharmacytodose.files.wordpress.com/2021/09/may_june-2021-references.pdf 06:40 – Six pack of studies; 41:00 – Anticoagulation/Reversal “Let it Bleed”; 55:40 – Sepsis with a sprinkle of random “Start Me Up”; 69:35 – PADIS “Ventilator Blues”; 78:50 – Pharmacist-driven studies “Front of the Fridge” PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Targeted Temperature Management (TTM) Special Guests: Scott Benken, PharmD, BCPS-AQ Cardiology, FCCM Reference List: https://pharmacytodose.files.wordpress.com/2021/08/ttm-references.pdf 08:05 – Preferred nomenclature; 09:20 – TTM history; 11:30 – Optimal temperature; 14:45 – Ways to lower temperature; 17:20 – Guideline recommendations; 20:50 – TTM2 trial; 28:05 – Future areas of research; 33:05 – TTM PK/PD changes; 39:50 – Shivering; 45:10 – Rapid-fire questions; 58:30 – Creating electronic TTM protocols; 61:15 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Mar/Apr 2021 Special Guests: Ashley Barlow, PharmD and Brooke Barlow, PharmD Reference List: https://pharmacytodose.files.wordpress.com/2021/07/mar_apr2021-references.pdf 07:19 – Six-pack of studies; 48:15 – Sepsis; 59:14 – Pain, agitation, delirium, and neuromuscular blockade; 73:50 – Infectious diseases and pharmacokinetics; 82:36 – Pharmacist-driven studies PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Sequence Intubation (RSI) Special Guests: Haley Peters, PharmD, BCCCP Show Notes: https://pharmacytodose.files.wordpress.com/2021/06/rsi-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2021/06/rsi-references.pdf 05:05 – Over-arching considerations; 09:45 – Neuromuscular blockers; 31:35 – Pre-induction agents; 46:46 – Induction agents; 72:23 – Obesity dosing considerations; 81:21 – Difficult airways; 84:30 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series Jan/Feb 2021 Special Guests: Abagail Kirwen, PharmD and Paige Morgan, PharmD Reference List: https://pharmacytodose.files.wordpress.com/2021/05/jan_feb2021-references.pdf 07:13 – Six-pack of Studies; 39:06 – Review Room; 52:20 – Glance at the Guidelines; 61:58 – Kinetics Corner; 73:37 – Front of the Fridge PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Updates in COVID-19 Pharmacotherapy Special Guests: Amy Dzierba, PharmD, FCCM, FCCP, BCCCP Mitchell Buckley, PharmD, FASHP, FCCM, FCCP, BCCP Show Notes: https://pharmacytodose.files.wordpress.com/2021/04/covid19-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2021/04/covid19-references.pdf 03:25 – Tocilizumab; 22:21 – Corticosteroids; 37:50 – Anticoagulation; 72:50 – Potpourri/Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

ICU Liberation (ABCDEF) Bundle Special Guest: Joanna Stollings, PharmD, FCCM, BCPS, BCCCP Show Notes: https://pharmacytodose.files.wordpress.com/2021/04/icu-liberation-bundle-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2021/04/icu-liberation-bundle-references-ii.pdf 03:48 – What is the ABCDEF bundle?; 08:35 – Barriers to bundle implementation; 12:14 – Excluding patients; 14:18 – A: Assessing/preventing/treating pain; 20:27 – B: Spontaneous awakening/breathing trials; 26:27 – C: Choice of sedation; 38:40 – D: Assessing/prevention/treating delirium; 42:09 – E: Early mobility/exercise; 45:40 – F: Family engagement and involvement; 49:16 – Importance of multidisciplinary involvement; 52:58 – Bundle implementation with COVID-19; 60:21 – Advice for those looking to implement the ICU Liberation Bundle; 64:30 – Pharmacist’s role in successful bundle implementation PharmacyToDose.Com @PharmacyToDose on Twitter [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Hypertensive Crises (Emergency/Urgency) Special Guest: Deepali Dixit, PharmD, BCPS, BCCCP, FCCM Show Notes: https://pharmacytodose.files.wordpress.com/2021/02/htn-crises-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2021/02/htn-crises-references.pdf 06:50 – Diagnosis; 09:17 – Clinical presentation; 11:14 – Common causes; 13:36 – HTN urgency management; 17:50 – HTN emergency BP goal; 23:26 - IV push v. continuous IV infusions; 28:30 – Aortic dissection/Esmolol; 34:10 – Acute ischemic stroke/Hydralazine; 40:25 – Intracranial hemorrhage/Nicardipine; 44:48 – ACS/Labetalol; 49:20 – ADHF/Nitrates; 56:08 – Miscellaneous medication pearls; 59:33 – Pregnancy treatment; 64:10 – Take-home points 4th Annual Multidisciplinary Tri-State Critical Care Virtual Symposium Details: https://rutgers.cloud-cme.com/course/courseoverview?P=5&EID=8158 PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Oncologic Emergencies Special Guest: Siu Yan Amy Yeung, PharmD, BCPS, BCCCP Show Notes: https://pharmacytodose.files.wordpress.com/2021/02/oncologic-emergencies-show-notes-1.pdf Reference List: https://pharmacytodose.files.wordpress.com/2021/02/oncologic-emergencies-references.pdf 06:00 – Oncologic emergency overview; 10:12 – Tumor lysis syndrome; 46:40 – Hypercalcemia of malignancy; 67:12 – Superior vena cava syndrome; 75:05 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trauma Alert Part II: ICU Management Special Guest: Melanie Smith Condeni, PharmD, BCPS, BCCCP Show Notes: https://pharmacytodose.files.wordpress.com/2021/01/trauma-alert-icu-management-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2021/01/trauma-alert-icu-management-references.pdf 05:25 – Pain, agitation, and delirium management; 24:30 – VTE prophylaxis; 48:47 – Open fracture antibiotics; 52:16 – Identifying infections; 57:03 – Neurostorming; 66:42 – TBI clinical pearls; 82:34 – Bowel regimens; 87:14 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Practice-Based Research Special Guest: Alex Flannery, PharmD, FCCM, BCCCP, BCPS Show Notes: https://pharmacytodose.files.wordpress.com/2021/01/practice-based-research-show-notes-1.pdf Reference List: https://pharmacytodose.files.wordpress.com/2021/01/practice-based-research-references-1.pdf 04:17 – Defining practice-based research; 06:02 – Importance of research; 12:38 – Developing infrastructure that supports research; 18:59 – Finding a good research idea; 22:15 – Research v. MUE; 25:48 – Reducing duplicate research studies; 28:00 – Developing an idea into a study; 31:52 – Study design resources; 35:23 – Research funding; 43:12 – Statistics; 47:05 – Manuscript publishing; 52:15 – Implementing results from practice-based research; 55:00 – Most common research pitfalls; 59:04 – Student/resident research mentorship; 62:00 – Practice-based research networks; 64:40 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Alcohol Withdrawal Disorder Special Guest: Kent Owusu, PharmD, BCCCP, BCPS Show Notes: https://pharmacytodose.files.wordpress.com/2020/12/alcohol-withdrawal-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2020/12/alcohol-withdrawal-references.pdf 05:50 – Consequences of alcohol withdrawal; 06:56 – Diagnosis/Pathophysiology; 11:15 – Treatment goal; 12:20 – Alcohol for withdrawal prevention; 15:30 – Benzodiazepine treatment considerations; 25:45 – Monitoring tools; 30:40 – Phenobarbital; 38:50 – Dexmedetomidine; 43:20 – Ketamine; 47:40 – Propofol; 51:43 – Valproic Acid and Gabapentin; 58:25 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trauma Alert Part I: Acute Management Special Guest: Brian Gilbert, PharmD, BCCCP, BCPS Show Notes: https://pharmacytodose.files.wordpress.com/2020/11/trauma-part-1-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2020/11/trauma-part-1-references.pdf 05:12 – Pre-arrival preparation; 14:19 – Pharmacist role on trauma team; 15:40 – Primary survey; 23:37 – Massive transfusion protocol; 27:00 – Viscoelastography; 40:34 – PCC administration and dosage; 44:40 – Calcium; 51:00 – RSI/PAD considerations; 56:10 – Open fractures and antibiotics; 58:37 – Elevated ICP management; 62:37 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2020 ACCP Annual Meeting Recap Special Guest: Anthony Hawkins, PharmD, BCCCP Reference List: https://pharmacytodose.files.wordpress.com/2020/11/2020-accp-annual-meeting-references.pdf 06:30 – Virtual v. in-person meetings; 30:35 – BIG announcement!; 34:15 – Poster sessions; 47:00 – Scientific sessions PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Pulmonary Hypertension Special Guest: Brian Murray, PharmD, BCCCP Reference List: https://pharmacytodose.files.wordpress.com/2020/09/ph-references.pdf 03:38 – Recent changes in PH management; 05:05 – PH classification; 10:22 – PH functional classification; 13:15 – PH diagnosis; 16:00 – Vasoreactivity challenge; 18:51 – Drug-induced PH; 21:08 – Short- and long-term PAH treatment goals; 23:50 – PH risk factors; 26:00 – Modifying outpatient PH medications/medication regimens; 33:03 – Fluid management in PH; 35:37 – VTE prophylaxis/treatment in PAH; 38:32 – Management of arrhythmias in PAH; 41:35 – CCB for PH treatment; 46:24 – Comparative studies in PH; 47:37 – Prostacyclins; 71:30 – Endothelin receptor antagonists; 76:04 – Phosphodiesterase inhibitors; 77:00 – sGC stimulator; 80:00 – Preferred treatment of PAH?; 84:53 – Vasopressors in patients with PH; 88:50 – Acute RV decompensation; 92:32 – Effect of positive pressure ventilation on PH; 94:55 – Management of outpatient PH infusion pumps; 97:22 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Antithrombotic and Anticoagulant Therapy with Cardiac Devices Special Guest: Craig Beavers, PharmD, FACC, FAHA, FCCP, BCCP, BCPS (AQ-Cardiology), CACP Show Notes: https://pharmacytodose.files.wordpress.com/2020/08/ap-and-ac-with-cardiac-devices-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2020/08/ap-and-ac-with-cardiac-devices-references.pdf 04:35 – MCS Overview; Case I; 07:45 – IABP Overview; Case I Continued; 17:17 – IABP Anticoagulation; Case I Continued; 24:03 – Impella Overview; Case IIl; 31:50 – Impella Anticoagulation; Case II Continued; 52:00 – LVAD thrombosis/bleeding management; Case III; 62:47 – Anticoagulation with Watchmen device; Case IV; 72:20 – TAVR overview; Case V; 80:45 – IV cangrelor; 82:37 – Does MCS reduce mortality?; 84:28 – Future research; 85:25 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Pediatric Critical Care Part I Special Guest: Joseph LaRochelle, PharmD, BCPPS, FCCP Resource List: https://pharmacytodose.files.wordpress.com/2020/08/pediatric-critical-care-part-i-resources.pdf 04:22 – Applying adult principles to kids?; 06:01 – Neonatal/pediatric vital signs; 10:25 – Pediatric/neonatal PK changes; 20:34 – Cytochrome P450 metabolism; 31:20 – Pediatric renal function/elimination; 44:22 – Pediatric v. adult dosing; 51:10 – Pediatric medication safety principles; 60:45 – Memorizing pediatric dosing; 70:13 – Pediatric weights; 74:26 – Pediatric Pharmacist training; 84:20 – Advice for Pharmacists; 86:43 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Ventricular Arrhythmias Special Guest: Matthew Wanat, PharmD, BCPS, BCCCP, FCCM Show Notes: https://pharmacytodose.files.wordpress.com/2020/07/ventricular-arrhythmias-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2020/07/ventricular-arrhythmias-references.pdf 04:00 – What are arrhythmias?; 05:30 – Why are arrhythmias harmful/dangerous?; 06:58 – Risk factors; 09:12 – Common atrial arrhythmias; 10:19 – General arrhythmia treatment principles; 12:45 – When to use rhythm control for AF; 14:37 – Adenosine; 22:04 – Non-sustained VT/PVCs; 27:00 – Monomorphic v. Polymorphic VT; 30:53 – Torsades de Pointes; 34:16 – QTc prolongation; 42:18 – VF v. VT; 43:29 – Pulseless VT/VF; 49:30 – Amiodarone; 54:55 – Lidocaine/Mextiletine; 64:10 – Sotalol; 67:40 – Sodium channel blockers; 70:25 – Isoproterenol; 73:43 – BB/CCB; 78:29 – Long-term management; 80:34 – Stroke risk with ventricular arrhythmias; 82:20 – Prevention; 83:40 – EKG Interpretation; 86:48 – Step-wise approach; 88:13 – Take-home points; 90:00 – Small talk PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

White Coats for Black Lives Special Guests: Earnest Alexander, PharmD, BCCCP, FCCM Sheriff Gbadamosi, PharmD Jason Jones, PharmD, BCPS, BCCCP Reference List: https://pharmacytodose.files.wordpress.com/2020/07/white-coats-for-black-lives-references.pdf 05:01 – How did we get here?; 27:16 – What emotions have you felt over recent events?; 45:40 – Why is this movement different?; 51:30 – Are these protests necessary/effective to enact change?; 59:20 – Inequality within the criminal justice system; 71:50 – Differences in treatment/outcomes for black patients; 83:43 – Systemic racism within US healthcare system; 87:09 – Is this a public health issue?; 91:55 – Importance of the diversity on the healthcare team; 95:35 – Increased pressure/stress being a black team member; 100:20 – Being an anti-racist; 104:40 – “All Lives Matter”; 109:55 – Powerful/Impactful media recommendations or further reading; 118:37 – Being a productive ally to the Black Lives Matter movement; 123:38 – Final thoughts PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

CRRT Medication Dosing Special Guest: Bruce Mueller, PharmD, FCCP, FASN, FNKF Show Notes: https://pharmacytodose.files.wordpress.com/2020/06/medication-dosing-in-crrt-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2020/06/medication-dosing-in-crrt-references.pdf 04:05 – Effect of AKI on patient outcomes; 08:40 – Different RRT modalities; 13:56 – How long has CRRT been used?; 17:35 – CRRT for all ICU patients?; 22:06 – When to avoid CRRT; 23:28 – CRRT definitions; 43:20 – Medication underdosing on CRRT; 51:27 – Older CRRT dosing studies v. newer studies; 54:29 – Drug properties that increase CRRT clearance; 58:36 – Does CRRT modality affect medication clearance?; 60:02 – Antibiotic retiming; 61:20 – Drug reference dosing recommendations; 64:20 – Dosing when patient is on CRRT and not in AKI; 66:40 – Anticoagulation for CRRT; 75:13 – Hybrid CRRT modalities; 81:45 – General dosing considerations; 83:23 – CRRT dosing drug references PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Aneurysmal Subarachnoid Hemorrhage Special Guest: Casey May, PharmD, BCCCP Show Notes: https://pharmacytodose.files.wordpress.com/2020/06/asah-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2020/06/asah-references.pdf 02:51 – Types of intracerebral bleeds; 06:19 – Types of subarachnoid hemorrhage; 08:25 – Pathophysiology of aSAH; 10:45 – Risk factors; 12:48 – Classic aSAH presentation; 16:36 – Classificiation systems; 22:25 – Prioritizating acute management of aSAH; 25:15 – Blood pressure goals; 26:21 – Preferred anti-HTN agent?; 28:25 – Biggest concerns with anti-HTN agents; 31:08 – ICP management; 35:40 – Surgical clipping v. Endovascular coiling; 42:51 – Cerebral vasospasms and delayed cerebral ischemia; 55:07 – Nimodipine in aSAH; 68:20 – DVT prophylaxis; 73:48 – Seizure prophylaxis; 76:30 – Augmented renal clearance; 83:56 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Acute Liver Failure Special Guest: Stephanie Bass, PharmD, BCPS, BCCCP Show Notes: https://pharmacytodose.files.wordpress.com/2020/05/acute-liver-failure-show-notes.pdf Reference List: https://pharmacytodose.files.wordpress.com/2020/05/acute-liver-failure-references.pdf 03:05 – Stephanie’s interest in the liver; 05:54 – Diagnosing ALF; 07:20 – Does having liver disease increase ALF risk?; 09:00 – Ultimate goal when treating ALF; 10:07 – Patient presentation; 11:58 – Common causes of ALF; 13:30 – ICP and cerebral edema management in ALF; 15:50 – PAD management in ALF; 18:55 – Acute hepatic encephalopathy management; 21:00 – Trending ammonia levels?; 22:25 – NAC for APAP overdose ALF; 27:11 – NAC for non-APAP overdose ALF; 30:23 – Albumin for ALF fluid resuscitation; 34:33 – Vasopressor use; 36:53 – Blood pressure goals; 40:00 – TEG for bleeding risk assessment; 43:45 – Hemostatic agents for coagulopathy; 46:18 – Anticoagulant of choice; 47:59 – Hepatic dose adjustments; 52:12 – Medication dosing with MARS/RRT; 54:00 – Medications to avoid; 56:02 – Transplant considerations; 58:24 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Critical Care Management of COVID-19 Special Guests: Drayton Hammond, PharmD, MBA, MSc, BCPS, BCCCP, FCCM Peter Nikolos, PharmD Show Notes: https://pharmacytodose.files.wordpress.com/2020/04/covid-19-complications-show-notes.pdf Mechanical Ventilation (Drayton) 08:00 – Non-COVID-19 PAD management; 11:16 – COVID-19 PAD management; 18:22 – Managing PAD drug shortages; 22:38 – Opioid conservation strategies; 26:08 – Propofol conservation strategies; 29:08 – Hypertriglyceridemia with propofol; 32:10 – Risk of PRIS; 34:30 – Ketamine; 41:05 – NMBA use and shortage; 46:00 – PPE conservation; 49:00 – Bronchodilator use for COVID-19; 50:28 – Inhaled anticoagulants; 52:46 – Inhaled pulmonary vasodilators; 54:17 – Advice for COVID-19 management Cardiovascular (Peter) 67:20 – Current shortages; 71:05 – First-line vasopressor; 73:25 – Vasopressor compounding and utilization changes; 74:50 – Smart pump management; 77:15 – Vasopressor shortage management; 79:45 – Anticoagulation treatment strategy; 85:30 – Anticoagulation monitoring; 86:28 – Anticoagulation in ECMO/CRRT; 88:20 – PE causing rapid decompensation?; 90:25 – Alternate anticoagulants; 92:52 – Thrombolytics in ACS; 98:13 – Code response changes; 100:05 – ACE-I/ARB use in COVID-19; 103:41 – NSAID use in COVID-19; 105:15 – Statin use in COVID-19; 107:25 – Challenges from virtual rounding; 110:20 – Key points on COVID-19 management PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices