Pharmacy to Dose: The Critical Care Podcast

Trial of the Week: PARAMEDIC2 Special Guest: Scott Benken, PharmD, MHPE, FCCP, FCCM, BCPS 06:20 – C4 conference preview 12:50 – PARAMEDIC2 trial of the week C4 conference registration link: https://c4conference.uic.edu/ Reference list: https://pharmacytodose.com/wp-content/uploads/2024/08/paramedic2-tow-references.pdf 2024 Pharmacy to Dose Award nominations: https://forms.gle/BTgirsv8uoFj7Rux5 PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series March 2024 02:40 – RCT’s 13:20 – Prospective observational/Post-hoc 20:30 – Reviews & SR/MA 27:05 – Retrospective 32:00 – PharmD-featured/Sweet Emotion 2024 Award nomination ballot: https://forms.gle/HG1ytSHjrcRCW3SA9 Reference list: https://pharmacytodose.com/wp-content/uploads/2024/08/march-2024-lrs-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series February 2024 Special Guests: Taylor Law, PharmD Meaghan Rettele, PharmD 08:05 – RCT’s 30:00 – Prospective observational studies/Guidelines 50:10 – Post-hoc/Reviews 58:55 – Retrospective 75:20 – PharmD-featured/Sweet emotion 2024 Award Nomination Ballot: https://forms.gle/HG1ytSHjrcRCW3SA9 Reference List: https://pharmacytodose.com/wp-content/uploads/2024/08/feb-2024-lrs-references.pdf Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: ROSE Special Guest: Christina Rose, PharmD, BCCCP, FCCM @CRosePharmD 05:40 – Pathophysiology/ACURASYS trial 13:45 – ROSE trial discussion 38:40 – Current role of NMBA in ARDS Reference list: https://pharmacytodose.com/wp-content/uploads/2024/07/rose-tow-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

HRS-AKI & Terlipressin Special Guest: Stephanie Bass, PharmD, FCCP, BCPS, BCCCP 05:45 – HRS and HRS-AKI diagnosis 17:00 – Albumin and volume status 23:55 – Terlipressin/vasoconstrictor treatment 52:00 – Medication safety considerations Reference List: https://pharmacytodose.com/wp-content/uploads/2024/07/hrsaki-terlipressin-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: BLING III Special Guest: Jason Roberts, BPharm, PhD, FSHP 05:10 – BLING research background 17:30 – BLING III methodology/results 53:50 – Practical application/future directions Reference List: https://pharmacytodose.com/wp-content/uploads/2024/07/bling-iii-rapid-reaction-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

ANNEXa-I Deep Dive Part II Special Guests: Scott Dietrich, PharmD, BCCCP Brian Gilbert, PharmD, MBA, BCCCP, FCCM, FNCS Todd Miano, PharmD, PhD, FCCM 03:13 – Safety/thrombotic findings 21:50 – Questions that remain 26:50 – Practical considerations 41:40 – P&T elevator pitch Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/annexai-deep-dive-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

ANNEXa-I Deep Dive Part I Special Guests: Scott Dietrich, PharmD, BCCCP Brian Gilbert, PharmD, MBA, BCCCP, FCCM, FNCS Todd Miano, PharmD, PhD, FCCM 05:40 – Brief ANNEXa-I study overview 20:40 –Primary composite outcome 26:40 – Anti-FXa levels 30:45 – Statistics/methodology questions Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/annexai-deep-dive-part-i-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series January 2024 Special Guests: Haley Torr, PharmD Nick Tran, PharmD 06:55 – Featured Articles 32:55 – PAD-IS articles 37:10 – Cardiology articles 46:00 – Heme articles 51:40 – Potpourri articles 60:05 – Pharmacist-featured articles 67:30 – Sweet Emotion articles Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/jan-2024-lrs-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: PROWESS-SHOCK Special Guest: Paul Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS @paulszumita 03:30 – Background studies/Setting the scene 30:25 – PROWESS-SHOCK discussion/Where are we now Paul Szumita joins to highlight a June Trial of the Week “Drotrecogin alfa (activated) in adults with septic shock” published in the New England Journal of Medicine in 2012. To fully understand the discussion regarding drotrecogin alfa, Paul and I review the mechanism of action and its proposed action in the treatment of sepsis. Then we review earlier studies and the controversy behind the FDA approval process. Finally, we go into detail on what Clinical Pharmacists were tasked with doing at the time based on treatment protocols or hospital restrictions. Then we dive into the Trial of the Week, discussing the study design and results. What was the mood in ICUs and Pharmacy Departments after this publication? How much did our sepsis care improve from PROWESS to PROWESS-SHOCK? What lessons did we learn with the Xigris FDA approval process? Is there a patient population that could still benefit from drotrecogin alfa treatment? Plus, trial fun facts, issues with calculating APACHE II scores, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/06/prowess-shock-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series 2023 Year-In-Review Special Guests: Jacquelyn Crawford, PharmD @jacuronium Kathleen Hartman, PharmD @HartKate8 04:30 – Neurology 11:05 – Cardiology 18:50 – Cardiac Arrest 26:30 – Pulmonary 35:00 – Sepsis 44:05 – Endocrine/Renal 52:30 – Trauma 61:05 – Infectious Diseases Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/yir-2023-lrs-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Ketamine for EM Agitation Special Guest: Justin Lin, PharmD, BCPS, BCCCP @jjlinpharmd Justin Lin joins to review the May Trial of the Week “Efficacy of ketamine for initial control of acute agitation in the emergency department: a randomized study” published in the American Journal of Emergency Medicine in 2021. We set the scene by discussing how this research idea started, review the classic agitation presentation at his institution, and highlight evidence comparing pharmacotherapy treatment options prior to this study. Then we dive into the Trial of the Week, discussing the study design and results. What was the biggest pushback from providers or the IRB? Any unique education strategies? Would results stay the same with increased IV push administration? What would the comparator arm be if this study was replicated today? Plus, the most challenging part of this project, Justin’s favorite agent, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/ketamine-for-em-agitation-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Sanford Guide Q&A Special Guest: Doug Black, PharmD 04:40 – Doug’s background/Sanford guide introduction 14:20 – Print v. digital guide/included content 34:35 – Tables/tools highlights 41:55 – Doug’s favorites/conclusions Sanford Guide Website: https://web.sanfordguide.com/ PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Code ICH Special Guest: Gabe Fontaine, PharmD, MBA, BCPS, BCCCP, FNCS, FCCM @gabe_fontaine 04:00 – Code ICH and history of ICU bundled care 15:15 – BP control 22:50 – Hemostasis 33:15 – Challenges & future directions Reference List: https://pharmacytodose.com/wp-content/uploads/2024/05/code-ich-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: MENDS2 Special Guest: John Devlin, PharmD, BCCCP, MCCM, FCCP @devlinpharmd 03:20 – PADIS background and research introduction 35:25 – MENDS2 discussion John Devlin joins to review the May Trial of the Week “Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis” the MENDS2 study, published in NEJM in 2021. We set the scene by discussing how John developed an interest with PADIS research, discussing PK/PD sedative properties and considerations, landmark trials prior to MENDS2, and how much background work is required for a large RCT. Then we dive into the MENDS2 trial itself. Any significant findings? Biggest methodologic differences from MENDS2 and previous studies? Most challenging process of blinding? Any potential safety concerns? How to avoid unblinding study patients (and why that’s so important)? Plus, trial fun facts, seeing your name in a NEJM research article, applying MENDS2 findings into daily practice, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/mends2-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: ANNEXA-I 02:35 – Study design/results 18:30 – Considerations/questions Reference List: https://pharmacytodose.files.wordpress.com/2024/05/annexa-i-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: DESIRE & In-Flight Medical Emergencies References Special Guests: Jim Miller, PharmD, BCCCP @millerjtm Michael Liu, PharmD, MBA, BCCCP, BCNSP, BCPS 04:05 – DESIRE trial 31:15 – In-flight medical emergencies The episode starts off with special guest, Jim Miller, helping review the DESIRE study as a Trial of the Week. We set the scene reviewing dexmedetomidine pharmacokinetic advantages and landmark dexmedetomidine research. Then we highlight the DESIRE trial itself discussing the study methodology and results. What was considered usual care with regards to sedation? What is the external validity in this trial? What was the effect of changing the primary outcome measure mid-study? Are there anti-inflammatory properties with dexmedetomidine? What did Jim’s novel research show? What would Jim and I want for sedation if mechanically ventilated? And much more. Then the episode closes with Michael Liu highlighting his experience assisting with an in-flight medical emergency. We review his AJHP article describing his experience. Was this his first time in this situation? Biggest difference between in-hospital and out-of-hospital emergency response? What advice would he give others? And so much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/05/desire-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

December 2023 Literature Review Series Special Guests: Jenna Self, PharmD Hannah Millard, PharmD 04:30 – Featured Articles 38:45 – Cardiology 49:30 – Potpourri 53:20 – Sepsis 60:00 – PharmD 65:00 – Sweet Emotion Reference List: https://pharmacytodose.com/wp-content/uploads/2024/05/december-2023-lrs-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

ACC 2024 Rapid Reaction: Part II Special Guest: Snehal Bhatt, PharmD, BCPS, FASHP, AACC @SnayCardsPharmD 04:05 – EMPACT-MI 29:35 – ULTIMATE-DAPT Reference List: https://pharmacytodose.files.wordpress.com/2024/05/acc-2024-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

ACC 2024 Rapid Reaction: Part I Special Guest: Ryan Caputo, PharmD, BCCP @RyanCaputo1 04:05 – DanGer Shock 29:15 – REDUCE-AMI Reference List: https://pharmacytodose.files.wordpress.com/2024/05/acc-2024-part-i-references-1.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Sequence Intubation (RSI): Part II Special Guest: Christine Groth, PharmD, FCCM, BCCCP @GrothChristine Angela Slampak-Cindric, PharmD, BCPS, BCCCP, FCCM @AngelaSlampak Kevin Kaucher, PharmD, BCCCP 04:05 – Guideline development/involvement 12:50 – 2024 guideline overview 25:10 – Pharmacotherapy recommendations/considerations 42:40 – Non-pharmacologic recommendations/guideline insights 70:30 – Research ideas/conclusions Reference List: https://pharmacytodose.files.wordpress.com/2024/05/rsi-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: ESETT Special Guest: Ashley McCormick, PharmD, BCPS, BCCCP Ashley McCormick joins to discuss the April Trial of the Week “Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus” the ESETT study, published in NEJM in 2019. We set the scene by reviewing ASM PK/PD properties and discussing if there was a standard of care first-line treatment. Then we do a deep dive into the ESETT trial of the week. Did the 75kg dose cap influence results? How appropriate was the BZD dosing? How does this % of seizure cessation compare to other studies? Where did this dosing scheme come from? Trial fun facts, medication safety considerations, and much, much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/04/esett-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Thrombolytic Dosing in PE: Versus Series Special Guest: Lauren Igneri, PharmD, BCPS, BCCCP, FCCM 05:20 – High-risk PE 23:00 – Intermediate-risk 37:10 – Cardiac arrest 52:30 – Closing arguments 57:15 – Bonus: TNK v. tPA Reference List: https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: SEPSISPAM Special Guest: Katherine Spezzano, PharmD, MBA, BCCCP @KatSpazPharmD Katherine Spezzano joins to discuss the April Trial of the Week “High versus Low Blood-Pressure Target in Patients with Septic Shock” the SEPSISPAM study, published in NEJM in 2014. We set the scene by reviewing the concept of autoregulation, guideline recommendations, and pre-SEPSISPAM research assessing BP goals in sepsis. Then we do a deep dive into the SEPSISPAM trial of the week. Would we see these same results with other vasopressors? Did each group meet their BP goal range? How do we balance AKI prevention and longer ICU LOS? What do our guidelines recommend now? Trial fun facts, alternate trial acronym ideas, and much more! Reference list: https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Glycemic Control in the Critically Ill: Part II Special Guests: Judi Jacobi, PharmD, FCCP, MCCM, BCCCP @JudiJacobi Michael Sirimaturos, PharmD, BCNSP, BCCCP, FCCM @MSirimaturos 04:10 – Becoming panel members 11:50 – Guideline scope and PICO questions 21:35 – 2012 v. 2024 guidelines 28:05 – Effect of TGC-FAST 30:40 – 2024 guideline deep-dive 42:00 – Clinical decision support tools 50:00 – Pediatric recommendations 54:40 – Important future research topics 66:05 – Guideline manuscript writing 76:10 – Take-home points Reference List: https://pharmacytodose.files.wordpress.com/2024/04/glycemic-control-in-the-icu-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series November 2023 Special Guests: Arjay Mendoza, PharmD, BCPS, AAHIVP Brock Townsend, PharmD @Townsend_PharmD 04:30 – Featured Articles 35:25 – Cardiology 48:05 – Precision-based medicine potpourri 58:50 – Infectious Diseases 69:10 – PharmD Reference List: https://pharmacytodose.files.wordpress.com/2024/04/november-lrs-2023-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: SOAP II Special Guest: Jessica Casey, PharmD, BCPS, BCCP @jmc_cardspharmd Jessica Casey joins to discuss the April Trial of the Week “Comparison of Dopamine and Norepinephrine in the Treatment of Shock,” the SOAP II study, published in NEJM in 2010. We set the scene by reviewing catecholamine vasopressor receptor physiology, guideline recommendations, and pre-SOAP II research. Then we do a deep dive into the SOAP II trial of the week. Did including all forms of shock help or hurt? How does the mortality in this study compare with others? Would this have been as positive of a study in 2024? What do the guidelines recommend now? Is dopamine dead? Will anyone take norepinephrine’s throne? Jessica and I review trial fun facts, stand-out supplementary materials, and much, much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/04/soap-ii-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trials of the Week: Landmark Nimodipine Studies Special Guest: Salia Farrokh, PharmD, BCCCP, FNCS @salia_farrokh Salia Farrokh joins to highlight two landmark studies with nimodipine, “Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage” published in NEJM in 1983 and “Effect of Oral Nimodipine on Cerebral Infarction and Outcome after Subarachnoid Hemorrhage: British Aneurysm Nimodipine Trial” published in 1989 in BMJ. We review aSAH treatments in the 1970’s and 1980’s and what evidence existed for nimodipine use before highlighting our two trials of the week. How does the study methodology compare from then to now? Where did our nimodipine dosing regimen come from? Is the term cerebral artery vasospasm out of date? Is it still appropriate to use evidence from the 1980’s in the 2020’s? Is there more to research with respect to nimodipine? What to do with missed nimodipine doses? We do a deep dive into all things nimodipine for aSAH, discussing the above and much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/04/nimodipine-trial-of-the-week-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Norepinephrine Position Paper and Sepsis Research Priorities Special Guests: Brittany Bissell Turpin, PharmD, PhD, FCCM, BCCCP @BissellBrittany Patrick Wieruszewski, PharmD, BCCCP @pwierusz Seth Bauer, PharmD, FCCM, FCCP, BCCCP @SethRBauer 07:30 – Norepinephrine position paper introduction 11:35 – When did we realize this and what are the implications? 36:00 – Key task force take-aways 51:00 – SSC Research Committee history 56:00 – Submitting and ranking research questions 27:00 – Top 5 clinical sepsis research priorities 62:00 – Basic science priorities Reference List: https://pharmacytodose.files.wordpress.com/2024/04/norepi-position-paper-and-sepsis-research-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Final Four Preview and More: 2024 Critical Care Trials March Madness Bracket Sepsis/Fluids Bracketologist: Clay Small, PharmD, BCCCP CV/Pulm Bracketologist: Jolie Gallagher, PharmD, BCCCP Bleeding/BG Bracketologist: Jason Hecht, PharmD, BCPS, BCCCP, FCCM Neuro/PADIS Bracketologist: Karen Berger, PharmD, FASHP, FCCM, BCPS, BCCCP 06:10 – Region recaps 32:10 – Final Four preview and predictions 45:30 – Revisiting pre-tournament predictions PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf Listener Bracket: https://pharmacytodose.com/2024/04/01/final-four-2024-critical-care-trials-march-madness-bracket-preview-and-recap/ 2024 Critical Care Trials March Madness blank bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series October 2023 Special Guests: Hailey Burns, PharmD @Hailey_rx36 Caitlyn Simonson, PharmD 03:45 – Featured Articles 38:15 – Neuro 50:10 – EM/Tox/Trauma 61:50 – Renal/Endocrine 66:38 – PharmD 70:10 – Sweet Emotion Reference List: https://pharmacytodose.files.wordpress.com/2024/03/october-lrs-2023-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Sweet 16 Preview and Recap: 2024 Critical Care Trials March Madness Bracket Preview 04:06 – First round recap 13:25 – Second round recap 19:05 – Sweet 16 preview PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf 2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Pharmacotherapy in the Critically Ill Pregnant Patient: Part II Special Guests: Allison Lankford, MD Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin 04:50 – Obstetric hemorrhage 18:20 – Ectopic pregnancy 22:30 – Hypertensive emergency 28:45 – Pre-eclampsia/eclampsia 35:00 – Lactation considerations 39:35 – Take-home points Pharmacotherapy “Caring for two in the ICU” articles: Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/ Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/ PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2024 Critical Care Trials March Madness Bracket Preview: Part II Cardiac/Pulmonary and Sepsis/Fluids Regions CV/Pulm Bracketologist: Jolie Gallagher, PharmD, BCCCP Sepsis/Fluids Bracketologist: Clay Small, PharmD, BCCCP PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf 2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2024 Critical Care Trials March Madness Bracket Preview: Part I Bleeding/Blood Glucose and Neuro/PADIS Regions Bleeding/BG Bracketologist: Jason Hecht, PharmD, BCPS, BCCCP, FCCM Neuro/PADIS Bracketologist: Karen Berger, PharmD, FASHP, FCCM, BCPS, BCCCP @karenccrx PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf 2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: CHAMPION PHOENIX Special Guest: Jack Pluenneke, PharmD, BCCP @JackPluenneke Jack Pluenneke joins to discuss a March 2024 Trial of the Week, “Effect of platelet inhibition with cangrelor during PCI on ischemic events” the CHAMPION PHOENIX trial, published in 2013 in NEJM. We review PK/PD advantages with cangrelor, go over the CHAMPION trials, and then highlight why the CHAMPION PHOENIX trial was necessary. Then we dive into the Trial of the Week: CHAMPION PHOENIX trial and discuss its findings as well as study design. Are these patients we’d see in our ICU? How does cangrelor compare to glycoprotein 2b/3a inhibitors? Is it a weakness that the comparator group uses clopidogrel? The episode closes with medication safety considerations, cangrelor’s place in therapy, and much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/03/champion-phoenix-trial-of-the-week-references-1.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Corticosteroids in the Critically Ill Special Guest: Andrea Nei, PharmD, BCPS, BCCCP, FCCM @Dre_pharmd 04:40 – Guideline introduction/background 08:35 – Scope/authorship 13:35 – PICO questions/recommendations 14:22 – Sepsis 17:20 – CAP 19:10 – ARDS 21:55 – Research priorities/Take-home points 28:50 – Working with your spouse Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: REDUCE Special Guest: Matt Duprey, PharmD, PhD, BCCCP Matt Duprey joins to discuss the March Trial of the Week, published in 2018 in JAMA: “The Effect of Haloperidol on Survival Among Critically Ill Adults with a High Risk of Delirium: the REDUCE Randomized Clinical Trial.” We review the history of antipsychotic pharmacotherapy treatment and prophylaxis in delirium, reviewing guideline recommendations from that time. Then we dive into the Trial of the Week: REDUCE trial and discuss its findings as well as study design. Would results be the same with another medication? Why is delirium research so challenging? Prevalent v. incident delirium? What’s the best outcome to measure? What questions still need answered? These questions and so much more are answered in today's episode. Reference list: https://pharmacytodose.files.wordpress.com/2024/03/reduce-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Pharmacotherapy in the Critically Ill Pregnant Patient: Part I Special Guests: Allison Lankford, MD Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin 08:05 – PK/PD changes 12:50 – Medication safety/Drug information resources 20:15 – Maternal sepsis 33:15 – ARDS 43:15 – PADIS 48:45 – Cardiogenic shock & cardiac arrest 59:00 – VTE Pharmacotherapy “Caring for two in the ICU” articles: Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/ Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/ PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Levetiracetam Rapid IV Push Special Guest: Olivia Morgan, PharmD, BCCCP, BCGP I’m joined by Olivia Morgan to discuss her first author 2020 Neurocritical Care article entitled “Safety and Tolerability of Rapid Administration Undiluted Levetiracetam.” We review previous administration techniques and discussing how this study came to be before highlighting all the findings from this Trial of the Week. Then we discuss how the protocol has changed since this study, administering other ASM via rapid IV push, and much, much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/03/keppra-rapid-ivp-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Glycemic Control in the Critically Ill: Part I Special Guest: Traci Grucz, PharmD, BCCCP @tmgrucz 04:50 – ICU hyperglycemia mechanism 09:52 – Background/landmark research 27:00 – Current recommendations 30:25 – Hyperglycemia and hypoglycemia tips/tricks 46:30 – Treatment considerations 54:50 – Take-home points Reference List: https://pharmacytodose.files.wordpress.com/2024/02/glycemic-control-in-the-icu-part-i-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series September 2023 Special Guests: Garrett Terhune, PharmD Caroline Blankemeier, PharmD 04:35 – Featured Articles 32:28 – Pulm 38:35 – PADIS 46:50 – Neuro 53:40 – Trauma 62:00 – PharmD 68:10 – Grab Bag Reference List: https://pharmacytodose.files.wordpress.com/2024/02/september-lrs-2023-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Immunotherapy Part II Special Guest: Matt McKenzie, PharmD, BCCCP @mgm485 04:40 – What is and when do we use immunotherapy? 09:00 – CAR-T cell therapy 15:20 – Standard ICU work-up 21:00 – Cytokine release syndrome (CRS) 35:00 – Immune effector cell-associated neurotoxicity syndrome (ICANS) 51:00 – Immune checkpoint inhibitors 64:30 – Summary and take-home points Reference List: https://pharmacytodose.files.wordpress.com/2024/02/immunotherapy-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Burnout and Well-being Special Guest: Brent Reed, PharmD, MS, PhD Candidate 07:25 – How did we get here? 09:05 – Defining and drivers of burnout 18:45 – Is it too late if we're already experiencing? 20:15 – Relationship between well-being and burnout 22:00 – Work:life balance 29:00 – Precepting and teaching 35:25 – Foundation of burnout prevention 38:30 – 5 step process for work design change 50:50 – Being proactive and short-/long-term fixes Reference List: https://pharmacytodose.files.wordpress.com/2024/02/burnout-and-well-being-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series August 2023 Special Guests: Katie Rogers, PharmD Eric Johnston, PharmD 04:35 – Featured Articles 39:00 – Sepsis 47:35 – Potpourri 52:45 – Infectious Diseases 61:45 – PharmD 68:15 – Grab Bag Reference List: https://pharmacytodose.files.wordpress.com/2024/01/august-lrs-2023-references.pdf PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2024 SCCM Congress Recap Special Guest: Anthony Hawkins, PharmD, FCCM, BCCCP Conference correspondent Anthony Hawkins returns to recap all the happenings from the 2024 SCCM Congress. We review Phoenix, likes and dislikes from the Convention Center, session highlights, exhibit hall review, favorite session titles, PharmD award winners, and much, more. 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2024 SCCM Congress: Tuesday Special Guests: Karen Berger, PharmD, FASHP, FCCM, BCCCP, BCPS Melanie Smith Condeni, PharmD, FCCM, BCPS, BCCCP Julie Farrar, PharmD, BCCCP Lama Nazer, PharmD, BCPS Joanna Stollings, PharmD, FCCP, FCCM, BCPS, BCCCP Andy Webb, PharmD, BCCCP 03:05: Star Research Presentation: “Effect of Antipsychotics on Agitation in ICU Delirium: Secondary Analysis of a Randomized Trial” featuring Joanna Stollings 10:43: Star Research Presentations: “Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients with Sepsis (PRO-CAN)” & “Diagnostic and Prognostic Value of Procalcitonin in Critically Ill Cancer Patients with Sepsis” featuring Lama Nazer 25:32: Clinical Pharmacy and Pharmacology (CPP) Year in Review presenter and moderator roundtable discussion featuring Karen Berger, Melanie Smith Condeni, Julie Farrar, and Andy Webb 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2024 SCCM Congress: Monday Special Guests: Caitlin Brown, PharmD, BCCCP, FCCM Marilyn Bulloch, PharmD, BCPS, FCCM Kayla Kotch, PharmD, BCCCP 02:55: Marilyn Bulloch discusses her role and experience as a 2024 SCCM Congress co-chair 28:30: Star Research Presentation: “Impact of Early Initiation of Phenobarbital for Alcohol Withdrawal Syndrome in the Critically Ill” featuring Kayla Kotch 39:00: Star Research Presentation: “A Multicenter Study of Pulmonary Embolism Patients Treated with Reduced- or Full-Dose Alteplase” featuring Caitlin Brown 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2024 SCCM Congress: Sunday Special Guests: Judi Jacobi, PharmD, BCCCP, MCCM Blake Robbins, PharmD, MBA, BCCCP 02:45: Quick review of the happenings on Sunday, January 21st from 2024 SCCM Congress 07:20: Star Research Presentation: “Standard vs. Augmented Corticosteroid Dosing in Mechanically Ventilated Patients due to COVID-19” featuring Blake Robbins 22:05: Discussion about the SCCM Glycemic Control in the ICU featuring Judi Jacobi Glycemic control guidelines: https://journals.lww.com/ccmjournal/fulltext/9900/society_of_critical_care_medicine_guidelines_on.277.aspx Star research presentation: https://journals.lww.com/ccmjournal/pages/articleviewer.aspx?year=2024&issue=01001&article=00030&type=Fulltext PROPHY-VAP: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00471-X/fulltext 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices

2024 SCCM Congress: Saturday The episode starts out with a preview of the 2024 SCCM Congress schedule as the conference starts Sunday, January 21 in Phoenix, AZ 11:25: Then I highlight 3 presentations with Pharmacist speakers from the SCCM Digital Congress Fill the Tank or Squeeze the Pipes? Fluid Administration Over Early Vasopressor Therapy for the Management of Shock with Olivia Marchionda, PharmD, BCCCP Anticoagulation Considerations in Critically Ill Oncology Patients with Heather May, PharmD, MSc, BCCCP, FCCM Pharmacologic Agents Used in the ICU for Palliation of Symptoms: What’s New? With Nicole Palm, PharmD, BCCCP, FCCM 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.Com @PharmacyToDose [email protected] Learn more about your ad choices. Visit megaphone.fm/adchoices