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040 This new study will change how you think about fatigue
Episode 48

040 This new study will change how you think about fatigue

Hypertrophy Past and Present · Chris Beardsley and Jake Doleschal

February 23, 20261h 25m

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Show Notes

In this episode of Hypertrophy Past & Present, Jake and Chris unpack a new hypertrophy study that illustrates how fatigue doesn’t just make training harder but can directly reduce the hypertrophic stimulus by lowering single-fibre mechanical tension. The episode opens in the Silver Era again with Henry Paschal’s 1950 “busy person” program then pivots into the core discussion: why fatigue mechanisms (CNS and calcium-ion related) dampen muscle growth, and what this implies for exercise order, rep ranges, and advanced training methods. 

Key topics include:

  • Henry Paschal’s 1950 routine
  • A new “repetition duration” study
  • How CNS fatigue and calcium-ion fatigue both serve the same function
  • Why max effort and slow velocity don’t always equal max recruitment and max tension
  • Programming implications: exercise order, rep ranges, RIR, clusters, and isometrics

Topics

hypertrophybodybuildingmuscle growthstimulating repsnatural bodybuildingresistance trainingsilver eraexercise sciencetraining frequencypre-steroid bodybuildingJake DoleschalChris Beardsley