Dr. M's Women and Children First Podcast

This is the third story of hope for us as a species. We have a level of control over our outcome that is baked into our DNA. Bridget R. Briggs, M.D. and I sit down today to discuss the clinical approach to epigenetics in patients especially women. She is a physician who specializes in Women’s Health. Dr. Briggs received her undergraduate degree from the University of California Los Angeles in Psychobiology. She then completed her medical degree from University of California San Diego School of Medicine before completing her residency in family medicine as well as internship in Obstetrics and gynecology. She has been in practice for 25 years in Southern California. She is the owner of two family medicine practices in California where she specializes in functional medicine and womens health. She is a well known speaker and educator on the topics of epigenetics and methylation in humans. Her story is personal regarding her deep dive into epigenetics and health based on her family's history and experiences to date. We take a winding road looking at the clinical applications of epigenetic understandings as laid out by the experts and trailblazers of DNA methylation and phenotypic change in animals and humans. We get into some controversial topics including vaccination, preparation for, avoidance of and much more. The conversation is open, honest and thoughtful. We finish with a hard look at the pregnancy state and how to achieve optimal outcomes for our offspring. It is another story of hope for humanity. Please enjoy my conversation with Dr. Bridget Briggs, Dr. M

Literature Review 1) Pericytes are critical cells that sit around the tiny blood vessels called capillaries of the body especially in the brain. They are involved in regulating blood vessel activity. They communicate directly with the endothelial cells making them super important in the activity of the blood vessel and metabolism at the local tissue interface. From the journal Cell Death and Disease we see: "Crosstalk mechanisms....And some other discussions on Cancer detection at physicals as well as the recipe of the week. Enjoy, Dr. M

Respiratory Syncytial Virus RSV is a 150 nanometer RNA virus that comes from a human orthopneumovirus that circulates in the winter primarily. Young children and infants infected with RSV mostly have upper respiratory tract symptoms where a subset develop lower respiratory tract disease known as bronchiolitis with the primary infection. It is the most common reason for hospitalization in infants between 0 and 6 months of age. Bronchiolitis appears as a wheezy, cough centric illness that rarely may progress to increased respiratory effort noted by wheezing, rales (lung crackles - sounds like stepping on leaves), chest wall rib retractions, grunting, fast breathing, nasal flaring and eventually respiratory hypoxia. If it persists, the event can rarely lead to respiratory collapse and death. Annually, 150 children under 5 years of age die from RSV in the US. Most of these children are premature births and have cardiopulmonary disease issues. Term healthy children rarely succumb to RSV in a serious way. A recent study of German infants and children hospitalized with RSV identified these risk factors: age <6 months, birth at 28–37 weeks gestational age, congenital defects, perinatal respiratory and cardiovascular disorders, and various other comorbidities as significant risk factors for ICU admission and death. ( Cai et. al. 2020) plus a mini lit review and a discussion on thanksgiving. Enjoy Dr. M

Covid 19 Post Mortem Part II The story of the Standard American Diet and its directional connection to death from Sars2 - Covid. Post Covid population health data has shown us that humans that chronically consume more meat, sugar, animal products and highly processed foods were associated with more death and morbidity if they contracted early versions of Covid19. The effect of consuming sugar products on mortality was considerable, and obesity has affected increased death rates and reduced recovery rates. (Kamyari et. al. 2021) (Greene et. al. 2021) (Merino et. al. 2021) - also a Recipe of the Week. Enjoy Dr. M

This week's guest is Professor Moshe Szyf. This is the second story of hope for us as a species. We have a level of control over our outcome that is baked into our DNA. Dr. Moshe Szyf joins the show today to discuss the social programming of the epigenome. Dr. Szyf and his colleague Dr. Meaney proposed over two decades ago the first set of evidence that the “social environment” early in life can alter DNA methylation launching the emerging field of “social epigenetics”. He also has illustrated that DNA methylation is a prime therapeutic target in cancer and other diseases to be explored and potentially manipulated for health. "Together, they discovered that our genetic code, the actual sequential structure of our DNA, can pretty much shrug off the influence of any external environmental factors, short of massive radiation. However, the expression of individual genes within that sequence can be permanently altered by such seemingly innocuous influences as diet or how others treat us. Once triggered, a group of molecules called a methyl group attaches itself to the control centre of a gene, permanently switching on or off the manufacture of proteins that are essential to the workings of every cell in our body. In most tumours, this DNA methylation pattern has been knocked awry, leading to a gene being completely deactivated or triggered to abnormally high activity." (McGill Reporter) Dr. Szyf received his Ph. D from the Hebrew University and did his postdoctoral fellowship in Genetics at Harvard Medical School before he joined the department of Pharmacology and Therapeutics at McGill University in Montreal, Canada. He currently holds the James McGill Professorship in Pharmacology. He is the founding co-director of the Sackler Institute for Epigenetics and Psychobiology at McGill and is a Fellow of the Canadian Institute for Advanced Research Experience-based Brain and Biological Development program. Szyf has been the founder of the first “Pharma” to develop epigenetic pharmacology “Methylgene Inc.” and the first journal in epigenetics “Epigenetics”. Please enjoy my conversation with Dr. Moshe Szyf, Enjoy, Dr. M

Covid 19 Post Mortem As you all know, after reading countless articles that I have posted about COVID and the policies that were put in place by "well meaning" bureaucrats, I have been highly critical of the events that took place and the US Government's failure on so many fronts. There are two seminal articles that have been written on these topics to date: 1) COVID-19 Origins: Investigating a “Complex and Grave Situation” Inside a Wuhan Lab, 2) COVID Lockdowns Were a Giant Experiment. It Was a Failure. A key lesson of the pandemic. 3) The third and equally critical article that remains unpublished is the story of the Standard American Diet and its direct connection to death from Covid.....also conversations on picky eaters and a recipe of the week. Enjoy, Dr. M

Delaying Gratification and Dopamine When we think of our current societal view on raising children, we have a conundrum. We want our children to experience the world as it is progressing through a technological viewpoint, a growth mentality. What does that mean? . When technology enters the learning process, we progress at log rates. We can process more information and incorporate it into our memory. For a simple example, let's look back in time. When I was in school, I had to go to the library and search through the library's archaic dewey decimal system to find a book to reference for information for a project or assignment. Time wasting to say the least compared to the internet age. It took forever to accumulate old data that was in a book. No real time action...Also a mini literature review and a recipe of the week. Enjoy, Dr. M

Randy Jirtle, Ph.D. This week's guest is Professor Randy Jirtle. Dr. Randy Jirtle joins the show for the second time today to discuss his new research on the imprintome, the regulatory regions that at the earliest stages of fetal development control our epigentic and thus our genetic outcome. This is the Hope locus. Time Magazine nominated him for person of the year in 2007 and had this to say about him: “Dr. Jirtle’s pioneering work in epigenetics and genomic imprinting has uncovered a vast territory in which a gene represents less of an inexorable sentence and more of an access point for the environment to modify the genome. His trailblazing discoveries have produced a far more complete and useful understanding of human development and diseases” — Time Magazine. This interview is ground zero for the Women and Children First Podcast as we discuss the underpinnings or mechanisms of disease risk for all humans as it relates to the environmental inputs of our lives that are driving health or disease at both the pregnancy and post natal periods. We look specifically at how maternal nutrition and later chemical exposure directly affected the health of the agouti mouse offspring. This experiment was the first of its kind and paved the way for a complete shift in human disease understanding. For parents, this podcast is really the beginning of everything that I am trying to convey regarding a healthy pregnancy and childhood. Without this interview, the following interviews will be more difficult to understand. The picture becomes very clear once his research is cemented in our minds. His biography is as follows: Professor of Epigenetics at the Department of Biological Sciences, North Carolina State University, Raleigh, NC, and a Senior Scientist at McArdle Laboratory for Cancer Research at the University of Wisconsin, Madison, WI. He was previously professor of radiation oncology and associate professor of pathology at Duke University, Durham, NC, where he had been a faculty member since 1977. He graduated with a B.S. degree in nuclear engineering in 1970 and a Ph.D. degree in radiation biology in 1976, from the University of Wisconsin-Madison. His awards list is long but the key to Dr. Jirtle is that he is a curious thinker and we are grateful for this. Please enjoy my conversation with Dr. Randy Jirtle, Enjoy, Dr. M

Nature Deprivation Disorder: As we are getting closer to the end of the year and the cold strikes us hard in the face, we have a tendency to hunker down indoors and avoid the outside. Video games and screens are omnipresent in many of our children's lives. They pervade their thoughts. They significantly limit their self-driven need and desire to explore, imagine and be present with nature, silence and life as it exists around them. Nature and natural actions are some of the best teachers of rational action and normalcy in any ecosystem....Autism etiology and a recipe round out the week. Enjoy, Dr. M

In a Nature study by Dr. Chassaing and colleagues we see a data set raising a legitimate concern regarding synthetic emulsifiers. Let us look at the title, dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome.....Emulsifiers are the topic today. Also, some information with a mini literature review and a discussion on power struggles. Enjoy, Dr. M

This week's guest is Professor Mahmoud Ghannoum. For over four decades, Dr. Ghannoum has been exploring a critical but neglected inhabitant of the human body, the fungus. Born and raised in Lebanon, Dr Mahmoud Ghannoum is the current Director of the Center for Medical Mycology at Case Western Reserve University. He began his scientific journey at Loughborough University in England where he studied the fungus candida and its health associated diseases. Coupling this work to his curiosity about the whole area of intestinal microorganisms in the human body, he has become one of the leading researchers in the world in this space. His discoveries include the knowledge that fungal organisms constitute an essential part of the microbiome. In fact, in 2010, Dr Ghannoum was the first scientist to identify over 100 native species of fungi in the oral cavity and that they are mostly friendly to us. Like with bacteria, there are good fungi as well as bad fungi. And just as it was startling to discover that we need positive bacteria in our guts, most people today are shocked to learn that their health depends on flourishing colonies of helpful fungi. Symbiosis in all things seems to be the flavor of the day and history has proven this to be what we should have always assumed. He is widely published in top journals as well as being the founder and director of Biohm, a company dedicated to microbiome analysis and management from the perspective of fungal and bacterial communities. He is the author of Total Gut Health. This week, Dr. Ghannoum and I look critically at the microbiome of humans from the well trafficked bacterial road to the less travelled fungal road. Enjoy, Dr. M

The Power of Suggestion Can our thoughts affect us at a biological level not just a subjective level? In a new study published in pre print in BioRxIV entitled: A thalamic circuit represents dose-like responses induced by nicotine-related beliefs in human smokers, we see some new research looking at the power of suggestion well beyond the placebo effect...... Plus a mini literature review as well as a discussion on autism etiology. Enjoy, Dr. M

Musk and Rand Elon Musk by Walter Isaacson is a book worthy of your time. He is an amazing writer and the context and content are so timely for the happenings of today. The story of Elon Musk remains one to be completely written, but it is being partially displayed in this new book that I am in the early stages of reading. The truth of the matter remains that Elon suffered some significant traumas as a child that have vexed him throughout his life. However, the triumph of his story that is an amazing lesson for all is that the traumas do not define your trajectory nor final outcome. Elon has proven what many others have before him. That in this country, you are the architect of your destiny. Your are NOT defined by your past in anyway. You are NEVER a victim unless you choose that path. You can always choose to rise above trauma and pain to be your best self. This is not to say that the trauma does not weigh on you and your psyche. To the contrary, as Elon clearly demonstrates, the past is in all of us. It will rise up at times to haunt us. Therein lies your work, to witness, work through and rise above it.....Plus a mini lit review as well as the recipe of the week. Enjoy, Dr. M

Literature Review: Over the past 15 years we have noted a connection between the intestinal microbiome and allergic/autoimmune disease activity in humans. This study continues to pull on this thread of knowledge. We see a direct correlation between a dysbiotic microbiome and human disease risk as young as 5 years of age. The upstream targets remain the same. Healthy food, avoidance of chemicals, consistent daily movement, exposure to normal macrobes and microbes, chronic stress mitigation, vaginal deliveries, breast feeding, avoidance of antibiotics/antacids and more.....Then Section II with - Are we addicted to food? and the recipe of the week. Enjoy, Dr. M

This week's guest is Chef Mark Allison, a highly accomplished culinary artist known for his innovative and healthy creations. Born and raised in England to a family with a deep appreciation for food, Mark developed a passion for cooking at an early age. He honed his skills by attending prestigious culinary schools and gaining practical experience in renowned restaurants around the world. He counts current and past job titles as the Corporate Executive Chef at Forever Oceans, the former Director of Culinary Nutrition at the Dole Food Company and the former Dean of Culinary Arts Education at Johnson & Wales University. With an unwavering commitment to excellence, Chef Mark has earned a stellar reputation for his meticulous attention to detail and creative flair. Throughout his career, Chef Mark has received numerous accolades and awards for his culinary expertise. His dishes have been featured in prominent culinary publications, and he has appeared as a guest chef on various television shows, where he shares his expertise and passion with a wider audience. Beyond his culinary prowess, Chef Mark is also dedicated to sustainable and ethical practices in the culinary world. He actively promotes the use of locally sourced, seasonal ingredients, and supports initiatives that minimize food waste and protect the environment. In two words, he is a culinary scientist. He looks at food through two windows, taste and cellular health. Both of which are important to my patients and me. We dive into why and how he does this effectively in a society that is not aligned in the same direction. He is the author of these books: 3 boys & a chef, 3 boys & a chef 2, Lets get smart about diabetes and 150 projects to get into culinary arts. Chef Mark Allison continues to push the boundaries of culinary artistry, captivating diners with his extraordinary creations and leaving a lasting impact on the culinary industry. His passion for food, commitment to excellence, and dedication to nutrition and sustainability make him a true culinary visionary. Please enjoy my conversation with Chef Mark, Dr. M

Maternal Microbiome Part II Mom has a gut microbiome that directly seeds her babies microbiome. This microbiome dictates human long term and short term health. Eating a diet loaded with fiber based fruits, legumes and vegetables will cause a highly diverse bacterial microbiome to exist and this existence is correlated with better long term health......plus a section on mate matching as well as the recipe of the week! Enjoy, Dr. M

Maternal Nutrition and the Microbiome - Part I This was a tricky topic to drill down into one article - so I split it into two. Bear with me on this topic as it is so important in the grander scheme of maternal and child health. The microbiome by definition: the microorganisms that reside in a particular environment. Pregnancy is a dynamic event where a woman's body changes radically, including epigenetically, hormonally, immunologically and physiologically in order to conceive and carry a baby to term. Pregnancy has always been a scientific fascination because of these changes. Now, we add the microbiome to the list, as it is the latest area of research that is shedding light on how pregnancy outcomes are determined. Part I This was a tricky topic to drill down into one article - so I split it into two. Bear with me on this topic as it is so important in the grander scheme of maternal and child health. The microbiome by definition: the microorganisms that reside in a particular environment. Pregnancy is a dynamic event where a woman's body changes radically, including epigenetically, hormonally, immunologically and physiologically in order to conceive and carry a baby to term. Pregnancy has always been a scientific fascination because of these changes. Now, we add the microbiome to the list, as it is the latest area of research that is shedding light on how pregnancy outcomes are determined...... also two sections on covid vaccines and disease... Enjoy, Dr. M

Robert Roundtree, MD This weeks guest is Bob Roundtree. Robert Rountree, MD, received his medical degree from the University of North Carolina School of Medicine at Chapel Hill in 1980 before completing a residency in family and community medicine at Penn State Hershey Medical Center. He augmented his medicine training with extensive postgraduate studies in nutritional and herbal pharmacology along with certification as a master practitioner of neuro-linguistic programming. Dr. Rountree has provided his unique combination of traditional family medicine, nutrition, herbology, and mind-body therapy in Boulder, CO, since 1983. He has recently opened Boulder Wellcare, a private practice specializing in individual healthcare consulting. He is coauthor of three books on integrative medicine,Immunotics: A Revolutionary Way to Fight Infection, Beat Chronic Illness, and Stay Well (Putnam, 2000); Smart Medicine for a Healthier Child (Avery Publishing, 1994); and A Parent’s Guide to Medical Emergencies (Avery, 1997). He is an amazing teacher about all things disease prevention based through a functional medicine lens. This week we dive into the world of autoimmunity and human health. Why is it happening? How can we stem the tide of immune auto reactivity? What are some treatment options? And so much more.... Enjoy, Dr. M

Literature Review 1) "Attention deficit hyperactivity disorder (ADHD) is a common mental behavioral disorder in children. Alterations in gut microbiota composition are associated with neurological disorders....Also discussions on CTE, Covid, Omega 3 Fats, and more... Part II is about learning how to talk to your children and finally the recipe of the week. Enjoy, Dr. M

Literature Review 1) What has happened in the realm of cancer incidence over the last decade? As one would expect, it is climbing especially for breast cancer and GI cancers....studies on plant compounds and neuronal health in babies, covid statistics and more. Also, information on nutritional misinformation and how to spot it. Plus a recipe of the week. Enjoy Dr. M

This weeks guest is Ryan Conklin a self described - light chasing, storytelling, thread puller, adventure bound tracker and student of myth and maps. He is transformational coach by day, and bartender and hospitalitarian by night. He is a thinker that has a beautiful way of seeing grief and leaning into it in a grounding and therapeutic way. We dive into the deep end of the pool as it relates to grief processing and life after a death. Dr. M

Literature Review this Week 1) From Cell Host and Microbe - "The microbiomes of cesarean-born infants differ from vaginally delivered infants and are associated with increased disease risks. Vaginal microbiota transfer (VMT) to newborns may reverse C-section-related microbiome disturbances. Here, we evaluated the effect of VMT by exposing newborns to maternal vaginal fluids and assessing neurodevelopment, as well as the fecal microbiota and metabolome. Sixty-eight cesarean-delivered infants were randomly assigned a VMT or saline gauze intervention immediately after delivery in a triple-blind manner...... and much more about the cutting edge science of today. Also a piece on napping followed by the recipe of the week. Enjoy, Dr. M

Today’s guest is Dr. Doug Thompson, a 27 year veteran of dentistry since he graduated from the University of Michigan School of Dentistry in 1996. Dr. Thompson is a teacher, researcher and trail blazer in the field of modern dentistry. Today we travel down paths that lead to explanations as to why oral health is so important to systemic and truly whole human health. We look back in time and follow a timeline to the present-day research that says that we have scientific knowledge through laboratory study that the oral microbiome, the bacteria that reside with the oral cavity, as well as the oral system’s function has far reaching effects on the heart, the intestines, pregnancy and general metabolic health. Over the decades, Dr. Thompson realized that the science needed a portal to the masses and other dental professionals. Usher in the project called the Wellness Dentistry network circa 2015 which is an internet-based community of dentists with a keen awareness of how oral conditions affect whole-body health. It is a forum for Dr. Thompson and colleagues to use research to develop advanced practice ideas to thwart systemic health concerns that may arise from oral health dysfunction. On his website, Integrative Oral Medicine, Dr. Thompson states that he believes in an interdisciplinary treatment model that coordinates dental care with other medical practitioners for total body health care for his patients. He employs advanced DNA bacterial testing methods and other leading-edge dental science to enable early risk assessment and personalized treatment planning. To me this remains the future of all healthcare disciplines, collaboration, cooperation and patient centered. Let us dive into the oral cavity with Doug Thompson. Enjoy, Dr. M

Here is a short written version of the fructose story in tandem with the podcast with Dr. Rick Johnson where we go deep. We are going to discuss the survival switch and fructose metabolism in specific as it relates to pregnancy. It will be another life changing discussion for many of us. Fructose is the natural sugar found in fruit, honey and root vegetables. Historically, humans consumed fructose in these natural whole foods and did so moderately. Since the 1970's, there has been a major rise in fructose consumption, primarily as a beverage.... Also, a discussion of fiber and neurodevelopment as well as a review of the book the Carpenter and the Gardener by Alison Gopnik. Enjoy, Dr. M

Asthma and Nutrition Part V Case presentation: DM is a 12 yo caucasian male who presented to integrative pediatric clinic for the first time at age 8 years with the chief complaint of moderate persistent asthma and allergic rhinitis. His past medical history relates one to three severe asthmatic flairs per winter requiring steroids and overnight hospital stays over the past few years. He had relatively mild disease in between major flares and was well controlled with a high dose inhaled corticosteroid making it difficult to predict these severe respiratory events. His mother brought him to our clinic for a different approach since they had failed to stop the flairs over the last 5 years.... and a blurb on choking prevention. Enjoy, Dr. M

This weeks guest is Dr. Peter Ungar. Dr. Ungar serves as Distinguished Professor of Anthropology and Director of the Environmental Dynamics PhD Program at the University of Arkansas. He received his PhD in Anthropological Sciences from Stony Brook University and taught Gross Anatomy in the medical schools at Johns Hopkins and Duke before joining the University of Arkansas faculty in 1995. He is an Honorary Research Fellow of the Center for the Exploration of the Deep Human Journey at the University of the Witwatersrand in Johannesburg, South Africa. Ungar has written or coauthored more than 200 scientific works on ecology and evolution for journals like Science, Nature, Proceedings of the National Academy of Sciences, Scientific American, and more. His work has focused on teeth, food choices and feeding in living primates, and the role of diet and environmental change in the evolution of human ancestors and other fossil species. We dive into the world of teeth, evolution and out current state of existence in modern society. Are our teeth matched for this environment? Enjoy, Dr. M

Asthma, Allergies and Nutrition Part IV - The Story - Micronutrients Zinc is a mineral involved in over 100 enzymatic reactions in the body! It is necessary in adequate levels for cellular metabolism and is critical for the function of our immune system, our skin and our gut lining. At the cellular level, zinc is necessary for protein synthesis, DNA synthesis and cellular repair in wound healing.....as well as sections on the book the courage to be disliked and Derek Sivers recent work. Enjoy, Dr. M

Asthma, Allergies and Nutrition - The Story Part III - THE NUTRITION STUDIES - THE TO DO There is good quality data on specific parts of a diet or nutritional plan as it relates to asthma. This section will detail these micronutrient and macronutrient benefits and how to implement them in an overall asthma plan. We will start by looking at a list of high quality nutritional interventions and then follow with an expanded view of a few critical players...... and a second section of mothers and death risk perinatally. To your health, Dr. M

This weeks guest is my former classmate and good friend, Dr. Jacquelyn Paykel. Jax, as I call her, is a tour de force in the world of Integrative Medicine at the Armed Forces level. She is a graduate of the University of Wisconsin in Milwaukee with a degree in Anthropology. She then obtained medical and residency degrees in Obstetrics and Gynecology at the University of Wisconsin in Madison. To round out her degrees, she completed an Integrative Medicine Fellowship at the University of Arizona as well as an MBA at the UNC Kenan Flagler Business School. She is the Chief of the Whole Health Service (WHS) at James A. Haley Veterans’ Hospital in Tampa, Florida, leading the first-of-its-kind VA WHS within the U.S. where they develop and implement novel patient-centered clinical and well-being services for patients and employees. A U.S. Navy Veteran, Dr. Paykel has mentored and consulted with VA Medical Centers across the country on implementation of Whole Health. She leads the development and national spread of THRIVE – a virtual Whole Health healing program. This week we discuss her work with the Veterans Administration Department and Whole Health Service. This work is a model for the entire country. Enjoy, Dr. M

THE NUTRITIONAL STUDIES We know that the foods that we consume affect our intestinal microbiome, our immune system, our metabolism and therefore have a significant effect on inflammation. Is this knowledge translatable to asthma? Let us look specifically at nutrition as it relates to Asthma. Are there specific diet studies available that lead us toward a unified diet for better asthma health? Can we make good recommendations for our patients on a macronutrient basis with fats, carbohydrates and protein ratios and types. Do we have data to support certain micronutrient needs in asthma and how a diet could provide these nutrients? How much can we trust the data?..... Enjoy, Dr. M

Asthma, Allergies and Nutrition - The Story Here is a long form look at asthma and allergies as I am preparing a lecture on asthma and allergies for a conference in October. I will break it up into a few parts for your consumption. Asthma is now well known to be an inflammatory disease based on the response to anti-inflammatory medications and pathophysiological evidence making it a prime candidate for anti-inflammatory nutritional interventions. The Standard American Diet is filled with pro-inflammatory highly refined and processed foods that are laden with excessive amounts of sugar and unhealthy fats thus promoting inflammatory pathways that exacerbate disease. The genesis of the inflammation is now believed to start in part in the intestinal and pulmonary microbiomes with the loss of immune tolerance. The intestinal microbiome is highly responsive to whole food dietary alterations. Uric acid, a by product of fructose metabolism, is becoming a known driver of inflammasome activation and local tissue inflammation We will discuss in depth the food choices that lower the inflammatory burden, the asthma phenotype and the food immune reactions that exacerbate disease........ Enjoy, Dr. M

This weeks guest is my friend, Dr. Paul Smolen, also known as Doc Smo by his friends, is a pediatrician with 38 years of experience caring for children and families. He is a graduate of Duke University (1974), Rutgers Medical School (1978), and Wake Forest University-N.C. Baptist Hospital (1982). At Wake Forest University he completed a residency in general pediatrics, served as chief resident, and completed a fellowship in ambulatory pediatrics. For over 38 years, he was an Adjunct Associate Professor of Pediatrics at the University of North Carolina-Chapel Hill helping to train a generation of medical students and pediatric residents as well as author several research papers. He is also the author of two parenting books, Can Doesn’t Mean Should (2015) and Great Kids Don’t Just Happen (2019). Doc Smo is a bona-fide expert in knowing what parents want and need to know about parenting and child health. Imparting practical and useful advice is the goal of every “Pedcast” that he produced over his podcasting career. This week we discuss his book Great Kids Don't Just Happen. Enjoy, Dr. M

Literature Review: 1) Is loneliness tied to an increase in death risk? A new study in Nature says yes to a degree of the pooled effect size of 1.32 for all cause mortality. (Wang et. al. 2023) In effect, that is a very large effect of the variable loneliness on death risk. Why would this be? Many reasons come to mind. The greatest of which is the control that our mind wields on our immune system. If we think in negative and in sad terms over a period of time, the immune system will shift into a pro inflammatory state and weakened pathogen killing which has massive downstream effects on physiology. 2) In an impressive inoculation study in the UK, researchers gave the ancestral strain of SARS2 to test subjects and then followed them for 2 weeks in quarantine........ Enjoy Dr. M

Outdoor Yard Safety Yard work season is here and for me, lots of happy times spent outdoors. I remember as a youth earning money mowing lawns. The work was fun and the money was happily accepted. My father was my mower safety coach. Unfortunately, despite good teaching, I still burned myself on the engine by not paying attention to where I was touching. I still spilt gasoline on myself. I still ran over projectile objects in the grass carelessly. Ah, youth.... Have a great day, Dr. M

Let us head back to the headwaters of HDL biology to find some more answers. If you did not read the original HDL piece or remember the basics of HDL biology, go back to Newsletter V13 #15 for a review. HDL as an associated biomarker of death risk has a U shaped curve with higher all cause mortality at very low and high levels of volume. Let us understand why? (Madsen et. al. 2017) Anything that causes more LDL, low density lipoproteins, to stay in circulation will raise one's risk of ASCVD or heart attack. The historical reality (as I have discussed for years) for why we would have these genomic mutations to have more LDL particles in circulation is 1) as a protection mechanism against bacterial infections which were common for thousands of years. The HDL and LDL particles have receptors on their surface to grab bacterial cell wall debris like LTE or LPS and remove them via the liver. This is a massive beneftit to the human species until recent times. 2) as a storage mechanism for calories/recirculation of metabolically expensive cholesterol. (Maile et. al. 2020)(Feng et. al.. 2019)(Trinder et. al. 2021)....... Enjoy, Dr. M

Do you know if you have periodontal disease? Do your gums bleed? Do your teeth hurt? Do you have red and beefy appearing gums? Do you floss daily? Do you brush two times a day? Do you have sleep apnea? Why does this matter? Well it turns out that gingival and tooth related disease is highly associated with cardio metabolic diseases. The main reason is that the bacterial microbes in the oral cavity can travel via the bloodstream to places far and wide in the body leading to inflammation and heart disease when the oral cavity is damaged and then manipulated. This especially occurs during tooth decay and periodontal decay phases of oral disease. There are also associations with autoimmune diseases making your oral health very important..... Enjoy, Dr. M

This weeks guest is my favorite researcher, Dr. Richard Johnson. He is the Tomas Berl Professor of Medicine and the Chief of the Renal Division and Hypertension at the University of Colorado since 2008. A graduate of the University of Wisconsin, Madison, with a major in Anthropology, and a graduate of the University of Minnesota Medical School, Minneapolis, he is a physician and nephrologist whose research has focused on the role of sugar, and especially fructose, in driving obesity, diabetes, high blood pressure and kidney disease. Much of this work has explored the role of fructose metabolism, especially the generation of uric acid, in driving this phenotype, and his work has included studies ranging from molecular biology, integrative physiology, and evolutionary biology. He is the author of The Sugar Fix which introduced the first low fructose diet, and also The Fat Switch which explores the role of fructose in driving the obesity epidemic. His newest book, Nature Wants Us To Be Fat, is a tour de force of the entire pathway of survival via metabolic events in the body related to fructose and the polyol pathway. This is a must read book. This podcast will follow up on the original conversation, podcast #14, and the exceptional work of Dr. Johnson this time looking at how we are mismatched metabolically for the environment of modern America and our food systems from the maternal health and perinatal perspective. Enjoy, Dr. M

This week we talk all about sweat and heat liberation. Sweating is a very important tool that the human body and most mammals use to eliminate unwanted stuff. In this case, the body primarily is eliminating heat and toxins via liquid sweat. When we exercise vigorously or it is a hot day or we find ourselves overheating while fighting an infection, sweat will pour from our skin through glands and an endothermic reaction. The water that is released caries heat from the body with it. It evaporates into the air liberating the heat and thus cooling the body. In this sweated liquid are electrolytes and toxins. Primarily, the sweat fluid has a natural release of small amounts of sodium and to an even lesser extent, potassium and calcium. This fluid will also facilitate the release of chemicals that the body does not like..... plus a few articles in a literature review. Enjoy, Dr. M

Breastfeeding Versus Formula Science versus Opinion I read with somewhat of a frustrated feeling a recent article in Scientific American entitled: It's Okay Not to Breastfeed by Kavin Senapathy. In principle, the reality of this statement is reasonable. Then you read the article as to what makes this reasonable. She states: "Exclusive breastfeeding is not imperative, and the “breast is best” mantra can be harmful to babies and parents, especially among marginalized people."(K. Senapathy 2023) Again, at first blush this may seem reasonable. Let's dig into the science and the truth of breast versus cow milk based formula for optimal health for a child. Does formula in all of its forms work for infant nutrition in order to grow and survive in a reasonable way? The answer is a resounding yes, however, this does not tell the whole story, far from it..... Enjoy, Dr. M

This weeks guest is Professor Marcel Nold, MD. Dr. Nold is a clinician scientist in the research environment of neonatal immunology and microbiomes at Monash University in the city of Monash in Melbourne, Australia. Professor Nold received his Doctor of Medicine degree at the JW Goethe-University at Frankfurt am Main, Germany, including final year rotations in Zürich (Switzerland), Montréal (Canada) and Capetown (South Africa). For his biomedical research training he spent six years at the Pharmazentrum at Frankfurt am Main and three years as a research Fellow at the laboratory of Professor Dinarello, at the University of Colorado Denver. In 2009 he was recruited to The Ritchie Centre in Melbourne and finished his specialist training at Monash Newborn. Professor Nold is a leading researcher worldwide in the field of immune cytokine signaling and was the key contributor to identifying Interleukin 37 or IL37. His research has been published in the journals Nature Immunology, Science Immunology and many others. His academic Inflammation in Neonatal Diseases Research Group and his industry programs aim to characterise underlying pathways of inflammation in early life diseases, with a focus on interventional immunology in cardiopulmonary and intestinal diseases of the preterm. For the purposes of this interview, Dr. Nold is a researcher with a view of the maternal child dyad that is prevention focused and health span conscious. His research has led to many critical discoveries in the neonatal health space that I find deeply intriguing. We get into some deep immunology at times which is critical for total understanding. Enjoy, Dr. M

Literature Review: This week we discuss articles about the Inhalation of polyamides or nylon in microsizes, masking and effectiveness, cannabis use in youth and covid 19 versus influenza and more. Part two is a look at research related to pollution and the risk of cardiac disease. Enjoy, Dr. M

Mental Health and Sleep for teens and college students, Mother's Day and a poem about mothers. Here are some highlights: Teenagers are sleep deprived and have been for decades. Nighttime sleep duration has consistently declined over the past few decades. Peak declinations occurred in the late 1990's and early 2000's. Girls were less likely than boys to sleep for 7 hours or more per night.... Enjoy, Dr. M

The Growing Brain and the Upstream Etiologies of Neurodevelopmental disorders - AUTISM This weeks guest is me! I re-recorded a lecture that I gave in Florida this month at the Annual International Conference for the Institute for Functional Medicine. My goal in this lecture is to look at the upstream reasons that we are seeing more Autism and neurological diversity in children year upon year. It is a wide ranging look at the current state of the science and my thoughts on a unifying theory. As with Dr. Stone's interview last week with Grow Baby, this is a follow up discussion that is a critical primer for "mother's to be" regarding disease avoidance measures that can be taken for the best health of the maternal child dyad. Enjoy, Dr. M

Literature review this week: Plastics in the blood, dogs can sniff Covid, mental health and exercise, CT scans and brain cancer risk, aging and the microbiome. Also, a piece on mothers and the shaming from social media critics. Recipe is coconut curry fish. For example: Brain Cancer - a single CT can raise the risk of cancer of the brain in children if the exposure occurs before age 22 years. Enjoy, Dr. M

Section I - An Uncivilized Journey Part II (Being Vulnerable part II) I continued my wandering journey of self discovery this year. Finding myself back in rural Austin, Texas, there would be no preconceived idea for me what this stop on the path would uncover and offer me in witness and self emotional understanding. Not to disappoint, this journey was easily 5X more mind and heart opening than last April. The past year has been tumultuous for me as you all may remember. I am still coming off the reality of losing my rock in the world, my father. It is a strange feeling. The knowing that he is gone and that I must live without his counsel, love and support. But, live we all must with loss, grief and existence..... Best, Dr. M

This weeks guest is an expert in the prevention of maternal pregnancy related metabolic disease and the downstream risks of metabolic dysfunction if left unchecked. Her bio: Leslie P. Stone MD, IFMCP, board certified in Family Practice, with a fellowship in Surgical Obstetrics. She is an international lecturer on Developmental Programming of Health and Disease (DOHaD) and application of individualized functional medicine care during pregnancy. Her passion is helping parents capture the miraculous before and during pregnancy by changing habits, their lives, and empowering lifelong resilience in their children, and their children’s children . She is a co-founder with Emily Rydbom CN, BCHN of GrowBabyHealth.com, an individualized nutrition and lifestyle program promoting generational health, and CMO for GrowBabyLifeProject.org. She has been delivering babies since 1982 and has delivered over 5000 children. She is owner of Ashland Comprehensive Family Medicine—Stone Medical in Ashland Oregon where she continues to practice. Her ongoing clinical research centers on combining developmental programming of health and functional medicine applied pre-conceptually and during pregnancy to optimize maternal and neonatal outcomes, with the intention of reducing the global epidemic of non-communicable disease (clinicaltrials.gov NCT05436119). Her undergraduate degree from Washington State University in Physiological Psychiatry was followed by her MD from University of Washington, Internship in OB/GYN Oregon Health Sciences University, residency at UCLA in Family Medicine, Surgical Obstetric Fellowship at UCLA Ventura, and further certification in Functional Medicine. growbabyhealth.com, growbabylifeproject.org

This week is a literature review where we look at the topics of school mental health struggles, safetyism, crispr therapy, immune skin cell programming and rapid weight gain in infants. Part II we discuss kitchen safety. We finish up with part III and estrogen, the microbiome and women's health. Enjoy, Dr. M

Last year, I wrote about an Uncivilized Journey that was very eye opening and transformative. This year, I went on a second journey deep in the fields of rural Austin, Texas where horses, turkeys and deer were living in peace. It was deeper and more moving than the first which is saying something. I am going to rerun last year's piece as it encapsulated the experiences well. Then I will tackle journey II in other weeks. Section II is more literature review. Enjoy, Dr. M

This weeks guest is Dr. terry Wahls. Who is she? From her website: Dr. Terry Wahls is a clinical professor of medicine at the University of Iowa where she conducts clinical multiple sclerosis trials . She is also a patient with secondary progressive multiple sclerosis, which confined her to a tilt-recline wheelchair for four years. Dr. Wahls restored her health using a diet and lifestyle program she designed specifically for her brain and now pedals her bike to work each day. She is the author of The Wahls Protocol: How I Beat Progressive MS Using Paleo Principles and Functional Medicine, The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles, and the cookbook The Wahls Protocol Cooking for Life: The Revolutionary Modern Paleo Plan to Treat All Chronic Autoimmune Conditions. She conducts clinical trials that test the effect of nutrition and lifestyle interventions to treat MS and other progressive health problems. Learn more about Dr. Wahls’ clinical trials here. She also teaches the public and medical community about the healing power of the Paleo diet and therapeutic lifestyle changes that restore health and vitality to our citizens. She hosts a Wahls Protocol Seminar every August where anyone can learn how to implement the Protocol with ease and success. Follow her on Facebook (Terry Wahls MD) and on Twitter at @TerryWahls. For me, this is a story of revolution. The ability to stop a progressive disease and reverse it through upstream lifestyle trigger removal and the addition of substances known to fix defects in human biology. This is the story that we all need to look at from a prevention of all cause disease perspective. This is the how to not get sick over time starting at the earliest age of life. Enjoy, Dr. M

Literature Review - this week we look at topics like: Autism is linked to heart disease!; Machine learning algorithms are going to help us diagnose autism spectrum disorders earlier; Long term gastrointestinal issues post Covid are real and problematical;Celiac disease screening for first degree relatives of a person with celiac disease is warranted;Watching violent video content in early childhood is associated with mental health struggles at age 12 and more... Part two discusses the length of antibiotic needed for pneumonia clearance. And finally a link to a discussion on snakes and bite prevention. Enjoy, Dr. M