Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics

<p><strong>Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity.</p> <p>In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF</p> <p>Check out our show notes <a href="https://www.drkarafitzgerald.com/fxmed-podcast/">https://www.drkarafitzgerald.com/fxmed-podcast/</a></p> <h3>Guest information</h3> <p><strong>Anurag Singh, MD, PhD</strong><br>Chief Medical Officer at Timeline</p> <h3>Thank you to our sponsor</h3> <ul> <li><a href="https://tinyurl.com/4npjcvjf">Timeline</a></li> <li><a href="https://tinyurl.com/ypfjws2e">Mitopure</a></li> <li><a href="https://tinyurl.com/53p6yjc9">Research from Timeline</a></li> <li>[email protected]</li> </ul> <p><strong>Timeline Discount for New Frontiers Listeners</strong><br> Timeline is offering DrKFs readers a 10% discount on Timeline products. Head over to <a href="https://tinyurl.com/4npjcvjf">Timeline</a> and use the code KARA10 at checkout.</p> <h3>Show Notes</h3> <ul> <li>Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity <a href="https://tinyurl.com/y3c2ypkw">https://tinyurl.com/y3c2ypkw</a></li> </ul> <li>Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55>= Years Old...<a href="https://tinyurl.com/bdzfccr8">https://tinyurl.com/bdzfccr8</a></li> </ul> <li>Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults <a href="https://tinyurl.com/2p9pjpxc">https://tinyurl.com/2p9pjpxc</a></li> </ul> <li>Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance <a href="https://tinyurl.com/2jkhmu9w">https://tinyurl.com/2jkhmu9w</a></li> </ul> <li>Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis <a href="https://tinyurl.com/mvrjxxsm">https://tinyurl.com/mvrjxxsm</a></li> </ul> <li>Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial <a href="https://tinyurl.com/fscfdd85">https://tinyurl.com/fscfdd85</a></li> </ul> <li>Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population <a href="https://tinyurl.com/e6npdvyp">https://tinyurl.com/e6npdvyp</a></li> </ul> <li>Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials <a href="https://tinyurl.com/2m2nzd56">https://tinyurl.com/2m2nzd56</a></li>

Dr. Sandison confesses that when she first heard Dr. Dale Bredesen talk about his work reversing cognitive decline and Alzheimer's disease she was skeptical. But when she started to apply the Bredesen principles in her clinical work and saw just how meaningful the improvements were to patients' symptoms and quality of life, as she puts it: "...how do I do anything else with my life, but basically tell as many people who will listen that this is possible?" She then went on to found the first two residential care facilities for individuals with cognitive decline that are based on the Bredesen approach. She's published research on her clinical outcomes and is continuing to gather more data for publication. The information and inspiration she shares are relevant to anyone dealing with cognitive decline, caring for someone with cognitive decline, or even those of us who want to preserve and optimize cognitive function as we move through life. I found her report that environmental toxins were one of the most common findings among her patient population illuminating. - DrKF <p>Head to <a href="https://www.drkarafitzgerald.com/fxme...">https://www.drkarafitzgerald.com/fxme...</a> for the transcription and all the resources.</p> <p><strong>Guest information</strong></p> <ul> <li>Dr. Heather Sandison, ND, Author Reversing Alzheimer’s</li> <li><a href="https://www.drheathersandison.com/">https://www.drheathersandison.com/</a></li> <li>Email: [email protected]</li> </ul> <p><strong>Thank you to our Sponsors</strong></p> <ul> <li><strong>Diamond</strong></li> <li>Rupa Health - <a href="https://tinyurl.com/yc26f6sj">https://tinyurl.com/yc26f6sj</a></li> <li>Biotics Research - <a href="https://www.bioticsresearch.com/">https://www.bioticsresearch.com/</a></li> <li>Integrative Therapeutics - <a href="https://tinyurl.com/47sfktzb">https://tinyurl.com/47sfktzb</a></li> <li><strong>Gold</strong></li> <li>OneSkin - <a href="https://tinyurl.com/ycxvz5we">https://tinyurl.com/ycxvz5we</a></li> <li>Mira - <a href="https://tinyurl.com/3pj4t338">https://tinyurl.com/3pj4t338</a></li> <li>TimeLine Nutrition - <a href="https://tinyurl.com/4bsdfczz">https://tinyurl.com/4bsdfczz</a></li> <li><strong>Midroll</strong></li> <li>Practice Better - Start your free trial and save 20% for 4 months on any paid plan with code KF20 - <a href="https://sites.practicebetter.io/new-f...">https://sites.practicebetter.io/new-f...</a></li> </ul> <p><strong>Show Notes</strong></p> <ul> <li>Reversing Alzheimer's by Dr. Heather Sandison :<a href="https://tinyurl.com/3hcywxxv">https://tinyurl.com/3hcywxxv</a></li> <li>Dr. Dale Bredesen: <a href="https://www.apollohealthco.com/dr-bre...">https://www.apollohealthco.com/dr-bre...</a></li> <li>Montreal Cognitive Assessment (MoCa): <a href="https://mocacognition.com/">https://mocacognition.com/</a></li> <li>Marama Residential Care Facility: <a href="https://www.maramaexperience.com/">https://www.maramaexperience.com/</a></li> <li>Study: Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline: <a href="https://www.ncbi.nlm.nih.gov/pmc/arti...">https://www.ncbi.nlm.nih.gov/pmc/arti...</a></li> <li>Study: Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project: <a href="https://www.ncbi.nlm.nih.gov/pmc/arti...">https://www.ncbi.nlm.nih.gov/pmc/arti...</a></li> </ul> <p><strong>DrKF Resources</strong></p> <ul> <li>Podcast: Addressing Root Causes of Neurodegenerative Diseases with Dr. Dale Bredesen: <a href="https://tinyurl.com/3f2jchcm">https://tinyurl.com/3f2jchcm</a></li> <li>DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: <a href="https://www.drkarafitzgerald.com/our-...">https://www.drkarafitzgerald.com/our-...</a></li> <li>Younger You Group Program: <a href="https://www.drkarafitzgerald.com/youn...">https://www.drkarafitzgerald.com/youn...</a></li>

Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF <ul> <p>Head over to <a href="https://www.drkarafitzgerald.com/fxmed-podcast/">https://www.drkarafitzgerald.com/fxmed-podcast/</a> for all the full transcription and all relevant links and resources.</p> <p><strong>Guest information</strong></p> <ul> <li>Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift.</li> <li>Email: [email protected]</li> <li>Facebook: <a href="https://www.facebook.com/neurohackercollective">https://www.facebook.com/neurohackercollective</a></li> <li>Instagram: <a href="https://www.instagram.com/neurohacker/">https://www.instagram.com/neurohacker/</a></li> <li>LinkedIn: <a href="https://www.linkedin.com/in/gregory-kelly-98b96b138/">https://www.linkedin.com/in/gregory-kelly-98b96b138/</a></li> </ul> <p><strong>Qualia Discount for New Frontiers Listeners</strong></p> <p>If you’re in your late 20’s or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to <a href="https://tinyurl.com/4mst9py9" target="_blank">https://tinyurl.com/4mst9py9</a> for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase.</p> <ul> <li>Dr. Gregory Kelly: <a href="https://neurohacker.com/people/greg-kelly">https://neurohacker.com/people/greg-kelly</a></li> <li>Neurohacker Collective: <a href="https://tinyurl.com/3zpsaw3s">https://tinyurl.com/3zpsaw3s</a></li> <li>Shape Shift: <a href="https://tinyurl.com/3zpsaw3s">https://tinyurl.com/3zpsaw3s</a></li> <li>Alternative Medicine Review: <a href="https://tinyurl.com/56ad9av9">https://tinyurl.com/56ad9av9</a></li> <ul> <li>OMEMI Trial - <a href="https://pubmed.ncbi.nlm.nih.gov/33191772/">https://pubmed.ncbi.nlm.nih.gov/33191772/</a></li> <li>REDUCE-IT Study - <a href="https://clinicaltrials.gov/study/NCT01492361">https://clinicaltrials.gov/study/NCT01492361</a></li> <li>ASCEND Study - <a href="https://ascend.medsci.ox.ac.uk">https://ascend.medsci.ox.ac.uk</a></li> <li>VITAL Study - <a href="https://www.vitalstudy.org/">https://www.vitalstudy.org/</a></li> <li>Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - <a href="https://tinyurl.com/2p85yx5f">https://tinyurl.com/2p85yx5f</a></li> </ul> <p><strong>DrKF Resources</strong></p> <p>Patient consults with DrKF physicians including Younger You Concierge: <a href="https://www.drkarafitzgerald.com/our-clinic/our-services/">https://www.drkarafitzgerald.com/our-clinic/our-services/</a></p> <p>Bio Age Lab Test: <a href="https://youngeryouprogram.com/bio-age-lab-test/">https://youngeryouprogram.com/bio-age-lab-test/</a></p> <p>Bio Age Self Assessment Quiz: <a href="https://youngeryouprogram.com/basa/">https://youngeryouprogram.com/basa/</a></p> <p>Younger You Group Program: <a href="https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/">https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/</a></p> <p>Younger You book: <a href="https://youngeryouprogram.com/book/">https://youngeryouprogram.com/book/</a></p>

I'm excited to welcome Dr. Barry Sears, the renowned creator of the Zone Diet and a pillar in our field. Dr. Sears has not only authored bestsellers but has also made incredibly important contributions to clinical practice which we still rely on today: He is, for instance, the scientist who put the use of the AA:EPA ratio on the map. Dr. Sears provides elegant and accessible explanations of the unassailable importance of diet in addressing inflammation, metabolic health, chronic disease, and longevity, and the role that fatty acids play in that milieu. And while he and I might not agree that polyphenols need to be absorbed intact for benefit - there's plenty of evidence that their postbiotic products are very important players, especially in their interactions with the epigenome - his concerns about the chemical structure of highly concentrated fish oil supplements (with the potential for isomerization, as he argues) has opened my eyes and is important, without doubt. I think the jury is still out as to whether there is a negative influence of isomerization in highly concentrated EPA and DHA, but it's worthy of further investigation and (importantly) is another factor in the argument for a whole-food approach. - DrKF <p>Check out the show notes at <a href="https://www.drkarafitzgerald.com/fxmed-podcast/">https://www.drkarafitzgerald.com/fxmed-podcast/</a> for all the relevant links and resources.</p> <p><strong>Guest information</strong></p> <ul> <li>Dr. Barry Sears, President, Inflammation Research Foundation and CEO of Zone Labs.Inc.</li> <li>Email: [email protected]</li> <li>Website: <a href="http://www.drsears.com/">http://www.drsears.com/</a></li> <li>Zone Living Website: <a href="http://www.zoneliving.com/">http://www.zoneliving.com/</a></li> <li>Inflammation Research Foundation: <a href="http://www.inflammationresearchfoundation.org/">http://www.inflammationresearchfoundation.org/</a></li> </ul> <p><strong>Thank you to our Sponsors</strong></p> <ul> <li><strong>Diamond</strong></li> <li>Rupa Health - <a href="https://tinyurl.com/yc26f6sj">https://tinyurl.com/yc26f6sj</a></li> <li>Biotics Research - <a href="https://www.bioticsresearch.com/">https://www.bioticsresearch.com/</a></li> <li>Integrative Therapeutics - <a href="https://tinyurl.com/47sfktzb">https://tinyurl.com/47sfktzb</a></li> <li><strong>Gold</strong></li> <li>OneSkin - <a href="https://tinyurl.com/ycxvz5we">https://tinyurl.com/ycxvz5we</a></li> <li>Mira - <a href="https://tinyurl.com/3pj4t338">https://tinyurl.com/3pj4t338</a></li> <li>TimeLine Nutrition - <a href="https://tinyurl.com/4bsdfczz">https://tinyurl.com/4bsdfczz</a></li> <li><strong>Midroll</strong></li> <li>Practice Better - Start your free trial and save 20% for 4 months on any paid plan with code KF20 - <a href="https://sites.practicebetter.io/new-frontiers-in-functional-medicine">https://sites.practicebetter.io/new-frontiers-in-functional-medicine</a></li> </ul> <p><strong>Show Notes</strong></p> <ul> <li>Dietary Control of Inflammation and Resolution - <a href="https://tinyurl.com/vadkjzf7">https://tinyurl.com/vadkjzf7</a></li> <li>The STRENGTH trial - <a href="https://tinyurl.com/282cz27m">https://tinyurl.com/282cz27m</a></li> <li>OMEMI Trial - <a href="https://pubmed.ncbi.nlm.nih.gov/33191772/">https://pubmed.ncbi.nlm.nih.gov/33191772/</a></li> <li>REDUCE-IT Study - <a href="https://clinicaltrials.gov/study/NCT01492361">https://clinicaltrials.gov/study/NCT01492361</a></li> <li>ASCEND Study - <a href="https://ascend.medsci.ox.ac.uk">https://ascend.medsci.ox.ac.uk</a></li> <li>VITAL Study - <a href="https://www.vitalstudy.org/">https://www.vitalstudy.org/</a></li> <li>Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - <a href="https://tinyurl.com/2p85yx5f">https://tinyurl.com/2p85yx5f</a></li> </ul>

Gear up for an enlightening dive with Dr. Tara Harding, a vanguard in the realm of women’s health and fertility. Renowned for her exceptional work as a family nurse practitioner and fertility coach, Dr. Harding brings a wealth of knowledge from her battle against infertility and medical gaslighting, all while breaking barriers and fostering a supportive community for those navigating the complex journey of infertility. This conversation not only highlights innovative diagnostic tools like Mira but also delves into the nuances of managing conditions like PCOS and endometriosis. Dr. Harding’s personal and professional journey is a beacon of hope and empowerment, underscoring the significance of comprehensive care in women’s health. Prepare to be inspired by her dedication to revolutionizing fertility care and advocating for patient empowerment. ~DrKF Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

Fellow clinicians, get ready for a mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. And being able to test the response of our treatments (and importantly, the synergistic response of multimodal interventions). It’s heady stuff, but amazingly, it is where we are headed today. Dr. Price illustrates the incredible potential this technology brings for personalized evidence-based medicine, such as tailoring interventions based on microbial markers or targeting specific lifestyle changes for Alzheimer's prevention. The podcast is a captivating exploration of cutting-edge concepts and provides a glimpse into the exciting future of healthcare. I was wowed by my conversation with Nathan and can’t wait to start kicking the tires on this baby. I know you’ll feel the same. ~DrKF Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

It was a career-defining (and perhaps life changing) moment when Dr. Vittorio Sebastiano, a reproductive biologist by training, realized that because we are able to create life, that same body of information could be harnessed to create youth - that is, radically reverse our biological aging process to a younger time point without losing cellular identity. In 2014, he and his lab began unpacking this epiphany. They made the radical decision to conduct their investigations in human cells and tissue rather than in rodents, with the expectation that such a start would be a better bridge to human clinical trials. Flash forward a decade and Dr. Sebastiano and his team stand poised to begin trials in humans. Dr. Sebastiano is, in my opinion, one of the most extraordinary scientists in the longevity space today who flies under the radar of most of us in functional medicine. In this podcast - which is actually two-in-one because I continued the conversation with him on a second date - you’ll hear about the remarkable work they’re undertaking at his lab. For example: They’ve created a biological clock that encompasses the whole genome consisting of millions and millions of CpG sites. They are able to clearly demonstrate the reversal of bioage using their methodology - a cocktail of Yamanaka factors plus, with clear time limits - which changes the epigenome first, and in so doing influences all of the hallmarks of aging. Teaser: they’ve identified one intervention routinely used in clinical practice that influences their bio age clock in the same way that their cocktail does. What is it? I was riveted with this conversation, as I am sure you’ll be. Leave a review if you like it, and - Yes - let me know what you think. I know this will prompt deep questions for you, as it did for me. ~DrKF Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

Aging itself stands as the paramount driver of disease. As functional practitioners, the question arises: How can we assess biological age to make precise corrections that foster both healthspan and lifespan? Enter the era of omics, where metabolomics emerges as an exceptional tool with transformative potential. I'm thrilled to welcome back Dr. Betsy Redmond, longtime friend and the senior education specialist at Diagnostic Solutions Laboratory, to New Frontiers to lead us on this discussion.Together, we'll take a deep dive into specific metabolites and pathways intricately linked to aging, mood, inflammation, and gut health and you’ll hear about equol, a rising star on the postbiotic scene. We'll even unravel some surprising insights from my own test results! Be sure to grab a copy of the Sample Report and pull up a seat for this fascinating discussion packed with valuable takeaways for yourself and your practice. ~DrKF You'll find it all at www.drkarafitzgerald.com/fxmed-podcast/

Working in healthcare brings a unique set of challenges and stressors. But the truth is that any of us can get to burnout through challenging circumstances of work or study. And the consequences can range from severe to devastating. Burnout still hasn't been fully understood or recognized by the medical profession and other industries - there is still no official diagnosis classification. Along with other mental health disorders, it is often still (wrongly) stigmatized and can even sometimes be seen as a "badge of honor," much to our detriment. Dr. Jonathan Prousky, Chief Naturopathic Medical Officer at the Canadian College of Naturopathic Medicine, joins me once again in this New Frontiers episode to explore the state of burnout in healthcare workers and beyond. Whether you work in our field or not, I guarantee you'll find it insightful. Together we explore the challenges we all face, and practical solutions to help you maintain your own health and well-being. As always, please feel free to share, comment, and rate - and let us know your thoughts on this important topic. ~DrKF Do You Think You Might Be Suffering From Burnout? Take this quiz to find out and learn how to prevent or reduce burnout naturally. www.drkarafitgerald.com/burnout

When it comes to mitochondrial health, few nutrients have burst onto the bioenergetics stage with quite the impressive force as the postbiotic rock star Urolithin A (UA). On this New Frontiers episode Dr. Chris Rinsch, co-founder of Amazentis / Timeline, shares the incredible scientific journey of UA's discovery and subsequent unfolding of its many benefits, as confirmed by multiple clinical studies. Together, we explore UA's mechanisms of action, including the role of the microbiome, and exciting preliminary research on UA's potential to reverse immune aging. Of course, our conversation wouldn't be complete without discussing the possible role UA may play in slowing down biological aging and extending healthspan - after all mitochondrial decline is one of the hallmarks of aging. Tune in and please leave us a review wherever you listen to New Frontiers. - DrKF Check out the Shownotes for the episode at https://www.drkarafitzgerald.com/fxmed-podcast/,

Did you know that "bone-eating" osteoclast cells are derived from immune cell precursors and are stimulated by inflammation, just like other immune cells? Or that bone has its own glycocalyx whose health is essential to realize the benefits of exercise for bone? Folks, Dr. Keith McCormick is back on New Frontiers with ever-more juicy pearls like these, and with important updates on bone care for functional medicine practitioners and patients alike. Dr. McCormick is living proof that osteoporosis and a history of multiple bone fractures - he had 12 between the ages of 45-50 - are not an irrecoverable life (or death) sentence. In fact, even as he nears 70, Dr. McCormick is out there competing in Ironman and pentathlon events, living his life to the fullest. Dr. McCormick is arguably the top thinker and practitioner on bone health from a systems and functional point of view. His nuanced navigation of diagnostic tools as well as both pharmaceutical and nonpharmaceutical interventions is fully comprehensive and deep. You'll want to tune in to find out how he navigates his patient cases, casting a wide net for underlying contributing factors, his go-to interventions for specific situations, how he doses supplements, and more. Please do let us know what you think, and leave us a review wherever you listen to New Frontiers, and don't forget to check out the show notes at DrKaraFitzgerald.com for all the relevant links and resources. ~DrKF

Over 270,000 new cases of breast cancer are diagnosed each year in the US. And while BRCA mutations often get the most press, there are other, potentially more critical factors we can address. Today, Dr. Ruth Hobson joins us to delve into the realm of breast health, shedding light on both modifiable and non-modifiable risk factors, and sharing real-life strategies for supporting our patients. We dive into a range of essential topics, from dietary and lifestyle influences to the ongoing debate around Hormone Replacement Therapy (HRT), and venture into the world of functional tests to evaluate hormones and metabolites crucial for comprehensive breast health. We’ll uncover the intricate connection between gut health and breast health - Did you know that breast tissue has its own microbiome?!? - and examine how inflammation, peripheral fat, and methylation impact cancer risk. Bring a pen and paper, this is a deep dive into the hormones and breast health that you won’t want to miss. ~DrKF

The epigenetic pioneer, Dr. Randy Jirtle, returns to New Frontiers to share his latest groundbreaking work. And I really do mean groundbreaking. Dr. Jirtle's work in mapping our "imprintome" is literally creating a brand new branch of scientific study that is expected to provide valuable insights and opportunities for epigenetially-targeted therapies, including nutrition and lifestyle. What I so appreciate about Dr. Jirtle's work is that it clearly demonstrates how we are not inescapably at the mercy of our genes. Instead, Dr. Jirtle views disease-associated genes as a starting point for the environment to direct its expression. Join me on this episode of New Frontiers to find out what your imprintome actually is, why it is so important, and what you can expect from this area of scientific discovery in the near future. ~DrKF

If you're a clinician and finding yourself pressed for time in your practice, you're certainly not alone. A recent survey of over 9,000 US physicians revealed that more than half are experiencing burnout. Fortunately, the field of functional medicine is rapidly evolving, bringing tools that promise to streamline and improve accessibility in our practices. Rupa Health is one such tool. In this episode of 'New Frontiers, I’m joined by Dr. Kate Kresge, Head of Medical Education at Rupa Health. Together, we'll explore the remarkable resources offered by this advanced specialty lab testing platform. We'll also dive into the profound impact of chronic illnesses on our society, the crucial role functional labs play in providing answers that lead to lasting solutions, and how Rupa Health is at the forefront of reshaping the healthcare landscape through continuous innovation. Don't forget to check out the show notes at www.DrKaraFitzgerald.com for all the relevant links and resources. ~DrKF

Get ready for an enlightening conversation as I welcome Dr. Izabella Wentz, renowned Thyroid Pharmacist and an accomplished author, to New Frontiers. We’ll talk about her new book and dive into the often underappreciated and enigmatic connection between adrenal dysfunction and hypothyroidism, and how extreme stress can accelerate aging and impact immunity. Dr. Wentz provides invaluable insights into her personally crafted transformation techniques that can pave the way for enhanced mental and physical well-being, spanning dietary adjustments, lifestyle modifications, targeted supplementation, circadian rhythm optimization, and the power of a resilient mindset. We also chat about the pivotal role of community support in effectively managing adrenal imbalances. Whether you’re an experienced practitioner or someone navigating your own health journey, this conversation promises to be both riveting and profoundly enlightening. So, let’s dive right in!~DrKF

In this episode, I have the pleasure of interviewing Mark Newman, the president and founder of Precision Analytical, the company behind the revolutionary DUTCH test. Mark is a true pioneer in the field of hormone testing, and in our conversation, we delve into the latest developments in this rapidly evolving field. We discuss how the DUTCH test has expanded to include additional markers, providing even more comprehensive insights into hormone health. During our conversation, we also address the controversy surrounding saliva testing for hormone analysis. Mark sheds light on the limitations of this method and why the DUTCH test offers a more accurate and reliable alternative. I’m sure you’ll find this interview as fascinating as I did, and it will be super helpful for identifying the best forms of hormone testing for your patients. So, without further ado, let’s dive into this enlightening conversation with Mark Newman. ~DrKF

Harvard's award-winning Dr. Charles Serhan isn't just an expert on specialized pro-resolving lipid mediators (SPMs), he is the scientist who actually discovered them. His breakthroughs opened up a brand new field of research and clinical application with immense potential. After all, chronic, unresolved inflammation is a contributor or cause of so many conditions. The growing body of research on the utility of SPMs continues to astound (although when you start to understand the mechanisms, it's perhaps easy to understand some of the "why") - pain, rheumatoid, osteo- and Lyme arthritis, macular degeneration, periodontal disease, uveitis, surgical recovery, and repetitive head injury, for instance, have all been shown to be potentially benefited by the ability of SPMs to promote inflammation resolution. Clinically, I consider SPMs in all conditions where unresolved inflammation is a contributing factor. Not only that, but SPMs appear to have some rather surprising additional effects including stem cell regulation, tissue regeneration, and inhibition of amyloid-beta peptide in Alzheimer's models (even restoring memory loss in mice). I am honored to host Dr. Serhan here on New Frontiers along with his esteemed colleague, Dr. Megan Sulciner. Dr. Sulciner is a clinician-scientist and resident in the Serhan Lab whose exciting work focuses on advancing postoperative outcomes for surgical patients as well as the role of SPMs in enhancing cancer therapy and preventing cancer metastasis. I’m sure you will love this insightful, tour-de-force conversation! ~DrKF

Vascular health is fundamentally essential to longevity and health span, and that’s why I’m thrilled to be welcoming Dr. Michael Twyman to New Frontiers. Trained as an invasive cardiologist, Dr. Twyman has made the shift to a more preventative approach, moving beyond traditional cath lab results to focus on the health of the 60,000 miles of blood vessels that carry vital blood, oxygen and nutrients to every organ in the body, with hopes of reaching patients before they reach the end stages of disease. In this episode we’ll look at endothelial glycocalyx dysfunction as the root cause of cardiovascular disease, and dive into the key roles of nitric oxide, circadian biology, and the oral microbiome on cardiovascular health. I know you’ll find this interview to be absolutely fascinating. Have a listen and leave me a comment let me know what you think. ~DrKF

I’m so happy to be here with Dr. Vincent Pedre to dig into emerging science on the microbiome. Dr. Pedre shares extensive clinical pearls from his vast experience in functional gut health in an approachable and fun way as he drills down on possible causes of the challenging gut epidemic we clinicians see in the increasing numbers of IBS patients walking through our doors. Dr. Pedre and I discuss how microbial diversity is the holy grail for reducing the risk of chronic disease, and how the gut disruptors of our time, (including food and environmental toxins, chronic stress, our over-sterilized world and lack of time in nature) are leading to many of the health challenges of the day. We get into current science on the impact of a high-fiber vs a diet high in fermented food on microbial diversity and immune activation. And there’s more: we talk about how where we live matters when it comes to our microbiome, the health- or disease-promoting post-biotics that are created, our optimal diet, overall health and our ability to create stress resiliency. It’s a lot -- and I’m sure you’ll be fascinated by Dr. Pedre and find numerous valuable insights to support your patients. Thanks for listening, and please leave me a review wherever you hear my voice. ~DrKF

As we gain insight into microbiome impact on our health, we need accurate tests that tell us not only what and how much is there, but also which metabolites, or post-biotics created that can have downstream effects. So today I’m thrilled to welcome the brilliant Dr. Erika Ebbel Angle, PhD, biochemist, CEO, and co-founder of Ixcela, to discuss their fingerstick gut microbiome test. We’ll discuss the 11 key markers, the value of a blood sample over urine, and the impact of endurance sports and chronic stress on health markers as revealed by the test. We also chat about my own results, how impressed I was by the insight provided – and how they clearly identified changes I could make to improve my markers. Listen and take notes -- I know I did! ~DrKF

Buckle up everybody, because this conversation is a big tour de force of where we are headed in regards to longevity and innovative technology within healthcare. I am joined by my friend, longevity investor and visionary, Sergey Young, to discuss his incredibly important mission of extending healthy lifespans of at least one billion people using technological breakthroughs AND by making longevity affordable and accessible. Sergey is a top 100 longevity leader and one of the co-creators of AGE REVERSAL XPRIZE, a global competition designed to cure aging. Today’s conversation looks at the fundamental issue of healthcare inequality, the democratization of access to healthcare, and dives into the current paradigm shift of using technology for disease prevention and reversal of biological aging. I’m sure you’ll enjoy this conversation as much as I did, and be wowed by the work of Sergey Young. ~DrKF

Imagine accurately determining the status of your skin’s age to tell whether it is younger or older than your chronological age, and then use this technology to determine whether expensive anti-aging serums and creams are effective, or actually causing more harm than good. Amazing, right? This is precisely the technology Dr. Carolina Reis Oliveira and her fellow stem cell biologists at OneSkin created and you will find this interview fascinating on so many levels – I know I sure did! After creating their skin clock, the OneSkin team discovered peptide OS1, which targets senescent cells, one of the root mechanisms of aging, and is being shown in current studies to have a positive effect on hydration, firmness, elasticity, and the skin barrier. Listen as Dr. Reis explains the science and ongoing studies exploring the possible benefits of OS1 for the skin microbiome, hair loss, inflammation, and overall health.

The therapeutic value of curcumin makes it a fabulous recommendation as both a foundational and medicinal supplement. And since finding a preparation that is bioavailable is key to efficacy, affordability, and patient compliance, I’m excited to have Dr. Sonia Malani (from Integrative Therapeutics) here to talk about the latest advances in curcumin deliverability. Dr. Malani breaks down the progress of curcumin deliverability and the keys to bioavailability in a way that is simple to understand and easy to pass on to our patients in order to help them move away from the less effective brands that are currently lining the shelves of local markets so they get the therapeutic influence we are hoping for. Lots to learn, let me know what think in this great interview sponsored by Integrative Therapeutics! ~DrKF

If you’ve followed my show for some time, you’ve probably come across the wealth of conversations I’ve had with the team at Precision Analytical about their DUTCH hormone tests – this is an ever-evolving topic that continues to pique my interest as a clinician looking to level up my toolkit. In today’s show, I’m pleased to dive into some of my favorite topics of fertility, menopause, and HPA function with Dr. Jaclyn Smeaton, ND. She’s the chief medical officer at Precision Analytical, sponsor of this episode, and a naturopathic physician who specializes in reproductive endocrinology and hormones. Today’s conversation is all about the latest research on hormone testing, some of our favorite interventions to address hormone imbalances and much more as you consider the best testing options for your patients. This is an incredibly useful conversation so make sure to tune in!

Today we are taking on a revolutionary and provocative topic that I suspect will be quite liberating for many of us women (and practitioners who work with women) – a deep dive into how to optimize exercise training and performance during pre-, peri-, and post-menopause. This topic is of great importance to me as a cyclist and, I have to say, there’s nuance in the way we women should approach training that is hormone-dependent. My guest Dr. Stacy Sims is a huge talent and a tremendous gift to our community — listen as we discuss why women need to train differently than men, including specifics about protein intake, fasting, hormone replacement therapy, and what types of training are best depending on where you are in your cycle or menopause journey. Grab a pen, you’re going to want to take notes! ~DrKF

As we find ourselves entering this fourth year since the world was first gripped by COVID-19, on an individual and practice level many of us are still grappling with its post-viral after-effects (long COVID). Drs Patrick Hanaway and Kara Parker, as well as my long-time mentor and former IFM CEO Laurie Hofmann, join me on this podcast to share the important work they have been doing in building practitioner tools and training to address this ongoing challenge (check out the links in the show notes). I just really appreciate their doable, data-driven, and continuous-learning approach, as I’m sure you will too. And if you’re working with COVID-19/long COVID patients (as all of us do, or will, at some point), you’ll want to familiarize yourself with their patient registry so that you too can be part of that essential data collection. - DrKF

One fascinating and incredibly important molecule to pay attention to in the field of healthy longevity is nicotinamide adenine dinucleotide (NAD+). It’s literally in every cell and contributes to over 300 different reactions in the body as a coenzyme substrate. Dr. Nichola Conlon, PhD, is an expert on NAD+ and launched Nuchido Laboratories (who sponsors this episode) to rigorously test and develop a NAD+ booster supplement packed with epinutrients. She joins me in this ridiculously interesting conversation where she explains role of NAD+ as a signaling molecule, its relationship with longevity proteins sirtuins, its impact on multiple hallmarks of aging, its relationship to the salvage pathway, NNMT and CD38. And that just touches the surface of all we discuss in today’s talk! I’m thrilled to have her with me and hope you enjoy listening. ~DrKF

I first met Dr. Heather Zwickey when she was my immunology professor in medical school and made sure to stay in touch with her ever since. Her command of the microbiome literature is frankly unparalleled – and I can always learn more from her and this podcast proves it. Join me in this New Frontiers conversation about the latest perspectives on the microbiome, and a great discussion of all things pre/post and parabiotics. We also get into the rise in autoimmunity conditions post-Covid and ways one can mitigate the risks of these conditions. Smart, timely, and always engaging – I know you’ll think so too. ~DrKF

I always appreciate talking to companies who heavily invest their time and dollars into preclinical and clinical science. And Timeline Nutrition, sponsor of this episode, is doing just that with dramatic results. They have figured out how to make a bioidentical Urolithin A, which compelling research has shown positively influences our mitochondrial health, with wide-ranging knock-on effects. In addition, since it relies on microbial formation from the right polyphenols within the gut, those of us without the right dietary precursors, or dysbiotic microbiomes, may not effectively produce it on our own. Please join me in this episode to learn more about the research and clinical applications of Urolithin A. And if you would be so kind, leave us a review and starred rating wherever you listen to New Frontiers! ~ DrKF

Dr. Wahls’ dramatic recovery from progressive, debilitating multiple sclerosis (she was wheelchair-bound at one point and unable to sit upright) using functional medicine principles continues to astound those who learn about it. She kindly returns to New Frontiers in this episode to give us her latest updates and refinements in her approach to healing. Tune in to learn how she weighs the importance of diet vs. supplements vs. e-stim, e-stim dosing strategies that worked for her, and the surprising effects of e-stim on BDNF and depressive symptoms. Dr. Wahls also shares her recommendations for omega-6:omega-3 ratios, cholesterol targets and more. And, if you suffer with multiple sclerosis there’s a chance to screen for one of Dr. Wahls’ upcoming trials. You’re in for a tremendous treat! -DrKF

If you’re a practitioner looking to level up your toolkit for regenerating the intestinal barrier and healing the gut, then this interview with Dr. Tom Fabian, PhD is exactly what you need. This fundamental piece of our functional medicine toolkit continues to progress, and today we’re zooming way out from just patching up the gut. Dr. Fabian and I dive into the dynamic nature of the barrier, including its circadian cycle, the role of prebiotics, polyphenols, probiotics, and postbiotics in epithelial regeneration and stem cell proliferation, and useful clinical pearls to assess barrier function using the GI-MAP stool test. So glad to have Tom back on New Frontiers, and Im sure you will be too! Let me know what you think! ~DrKF

How much do we really know about the microbiome? What does it take to identify new probiotic strains and their associated health benefits? When should we leverage precise single strains and when is it more effective to use synergistic blends? I am grateful to talk again with the brilliant scientist and incredibly courageous entrepreneur, Dr. Colleen Cutcliffe. Colleen has over 20 years experience managing and leading teams in biotech, pharma, and academia — I just love picking her brilliant brain! She completed her postdoc research at Northwestern’s Children’s Memorial Hospital and earned her PhD in biochemistry and molecular biology from Johns Hopkins. In this episode of New Frontiers, we explore novel probiotic strains such as Clostridium buytricum, Clostridium beijerinckii & Anaerobutyricum hallii, discuss their synergy in producing short-chain fatty acids and potential to stimulate satiety-inducing GLP-1, and so much more! I commend Colleen and the team at Pendulum for their dedication to bringing new & challenging science and next-generation probiotics to the world. I sure learned a lot, and am sure you will, too. Let me know with a comment, review, and rating wherever you listen to New Frontiers! ~DrKF

Dr. Michael Roizen is an extraordinarily well-read, well-researched, and experienced physician in the field of longevity medicine. He dates his first interest in the field back to 1979 as head of an intensive care unit, when he recognized that patients who were biologically younger dramatically reduced their risk for post-operative disease and death. Since then, he has worked tirelessly in many ways to help individuals get physically and mentally younger, improving the lives of patients and documenting millions of dollars of savings per year in employee healthcare costs at Cleveland Clinic. In our conversation, he shares his lifestyle-forward approach, one that sits well alongside the Younger You program. Tune in to find out the importance of “posse, purpose, play, and locus of control,” how you can be your own genetic engineer, his take on emerging anti-aging interventions, and much more. As Dr. Roizen reminds us, it’s never too late to start – “until you’re six feet under, it ain’t too late to do this.” -DrKF

Why are we often resistant to tackling stress and preprogrammed thought patterns? It’s a curious phenomenon that occurs even in those of us who really know the central role these psychological factors play in health, disease, and even aging. That’s why I'm thrilled to interview resilience expert Dr. Stephen Sideroff. After all, a full 25% of the bio-age clock we used in our clinical study is driven by epigenetic patterns on stress-related genes. If you’re looking for the right motivation or framework to begin your own journey into stress resilience, or even if you need that next-level exploration of what really makes you tick psychologically and how you can truly optimize your functioning on all levels, you’ll want to hear what Dr. Sideroff has to say. For practitioners, you’ll discover an excellent intervention to add to your functional medicine and healthy aging toolkit. Listen in, and let us know what you think with ratings, reviews, and emails! Thanks so much for your time -- and enjoy! - DrKF

In this New Frontiers in Functional Medicine® podcast, Dr. Tom Fabian delivers a well-justified challenge to our current thinking and a chance to build a more nuanced approach that will improve patient results around the topic of hydrogen sulfide, a compound that we have typically thought of as the “problem child” behind certain difficult SIBO cases. However, there is a LOT more to know about it, such as its ability to convert to potent antioxidant compounds, and its therapeutic roles in cardiovascular and metabolic disorders (diabetes and NAFLD), neurodegenerative disorders, and more. But how do we start to both broaden and nuance our approach to assessing hydrogen sulfide status? And what interventions can not only supply the substrates for beneficial hydrogen sulfide production, but also help achieve that all-important balance between too little and too much. Listen in to find out, and let us know what you think! ~DrKF

Functional medicine providers are well versed in addressing the myriad manifestations of autoimmune disease, but while our success rates are remarkably high, we still aren’t always able to help everyone using current toolsets (labs, sophisticated elimination diets, gut protocols, and so on). Enter Mymee, a digital app and coaching platform that helps plug that gap – this sophisticated tool helps identify elusive trigger foods and lifestyle factors that may still be contributing to an individual’s disease process. Mymee’s work with COVID long-haul patients and the Mount Sinai post-COVID treatment center (long-COVID is highly autoimmune-related) is impressive and especially relevant for clinicians and patients alike. Some fascinating patterns are emerging from their long-COVID patient data that feed directly back into how to approach these cases differently. I am sure you will find this as interesting and useful a conversation as I did! Please review New Frontiers wherever you hear my voice and let us know what you think! ~DrKF

It’s always a pleasure to tap into Dr. Raffaele’s brain, and in this podcast he doesn’t disappoint. In fact, his practical contextualization of where we are with anti-aging medicine might just be one of the smartest you’ve heard yet. What is truly remarkable about Dr. Raffaele is not just his grasp of the field both scientifically and clinically, but his ability to apply a nuanced approach that is tailored to each individual patient. After all, as he eloquently points out, we must first figure out which of the many components of aging needs improvement or correction, then target our approach accordingly. The simplicity of that statement belies his firm grasp of the complex landscape of anti-aging assessments and interventions, as you’ll see. One of the important topics that surfaced in our conversation is the role of telomere length. Dr. Raffaele has been measuring telomeres in study cohorts and in his patient population for well over a decade. Has looked at well over 2,000 telomere length measurements, many of them longitudinally. Not only that, but he has also integrated telomeres alongside other biomarkers of aging, including DNA methylation clocks, and tried-and-true metabolic markers such as lipids. So, if you thought newer approaches to biological age assessment were making telomeres and other assessments redundant, think again. We’re entering a time where we must wrestle with how to incorporate and act on all these important measures. ~DrKF

I am always excited to share new and practical ways to bring Younger You principles to your dinner table and/or clinical practice. And this podcast is especially exciting where Jill Sheppard Davenport and I dive into using broths and tonics as health-promoting and healing foods. Yes, these have been part of our natural medicine toolbox for eons, but we discuss a new spin on this ancient medicine and turn up the volume on superfood and epinutrient ingredients for their myriad health benefits, including bio age reversal properties. We also address important concerns around the potential for bone to harness lead and other toxic metals – so important, we actually researched this very question ourselves, cooking broth from various bone sources and sending it all to the lab for thorough testing. You’ll be relieved by what we discovered (we were!). If you’re intrigued to learn more and start cooking up your own amazing combinations, preorder your copy of our new book, Better Broths and Healing Tonics today! We have some gifts for you if you do – check the show notes for more info. ~DrKF

Are we getting enough nutrients from our diet? And why do nutrient deficiencies persist even in those of us who are putting a lot of attention to what we're eating? Join me and Chris Kresser as we dive into all things nutrient insufficiencies on this episode of New Frontiers. Chris is the founder of the Kresser Institute and the co-founder of the California Center for Functional Medicine. He’s the bestselling author of The Paleo Cure and Unconventional Medicine and a highly respected clinician in our space. We talk about the inadequacies of RDAs, the latest statistics on nutrient insufficiencies, the importance of nutrient bioavailability and nutrient synergy and why taking supplements on top of a really poor diet is not going to help. We also marvel at the wonders of magnesium, the interplay between vitamins D, K2 and A, and calcium plus so much more! It is a conversation filled with clinical pearls and practical implications, so get ready to take notes and tune in! ~DrKF

Many of us in the functional medicine space are thinking about Akkermansia: what exactly makes this gut bug a keystone strain for health and longevity? I am excited to tackle this with a founder of Pendulum Therapeutics, Colleen Cutcliffe, PhD, an excellent scientist and a leader in biotech. Her passion to help her daughter, and many others, overcome food sensitivities inspired Colleen to use biotech and research to develop products that have the efficacy of a drug, but the safety of a probiotic. We cover it all, and then some! Enjoy, and let me know what you think. ~DrKF

Folks, WOW — what a great conversation on all things hormone testing with Dr. Laura Neville from Doctor’s Data! We share the same alma mater, National University of Natural Medicine, as well as extensive experience in clinical lab testing, so had lots to talk about! On this episode of New Frontiers, we discuss what different testing methods tell us about patient’s hormone status, which specimens are best for monitoring hormone replacement therapy and non-HRT interventions, why high dose progesterone carries risks, and what makes liquid urine testing stand out from the rest. Dr. Neville shares many clinical pearls from her experience reviewing thousands and thousands of tests with physicians from around the world. You’ll absolutely want to bookmark for future reference! Thanks for listening and please share, comment, and leave us a starred review if you wouldn’t mind! ~DrKF

As a longevity aficionado, I am so excited to be talking to Dr. Morgan Levine in this episode of New Frontiers! Renowned for her research on the science of biological aging, Dr. Levine specifically uses bioinformatics to quantify the aging process. She's played a vital role in developing and retraining several well-published bio age clocks, including the PhenoAge and Horvath clocks, making them much more reliable. Needless to say, I’m a big fan! Morgan and I dive into the fascinating science behind her new book, True Age: Cutting-Edge Research To Help Turn Back The Clock, and cover loads of important topics such as vetting bio age clocks, the role of the DNA methylome, how standard labs such as CBCs and CMPs can be used to calculate bio age, the controversial debate around immortality, challenges of applying the Yamanaka factors in clinical practice, how racial disparities affect biological aging – and believe me, so much more! I hope you’ll enjoy this thrilling conversation as much as I did, and please give me your feedback wherever you listen to New Frontiers - DrKF

Eating for longevity. A topic I’m very passionate about and one that has received incredible attention lately. How much protein should we eat to live longer? What about ketones, carbohydrates, and blood sugar spikes? Where does fasting fit in all of this? And what physical activity confers the most benefit for our healthspan? On this episode of New Frontiers, I pose all of these questions and more to one of the most brilliant minds in longevity science – Dr. Valter Longo. I’m so excited to have him as my guest once again – his grasp on the longevity literature is extraordinary, as is his immense contribution to this growing body of research. Dr. Longo and I discuss the fasting-mimicking diet, biological aging, macronutrient targets, the lifestyle pillars of centenarians, and much, much more. It was such a fun (and research-packed)conversation, just wait until you get your ears on it! As always, I would appreciate a thumbs up and a kind review wherever you listen to New Frontiers. - DrKF

What do we know about using specific probiotics for different health conditions? And is it time to move away from broad-spectrum probiotics and into condition-specific strains? With an explosion of new research on probiotics and a recent change in nomenclature, it’s easy to get confused. In this episode of New Frontiers, I lean on Dr. Noelle Patno’s extensive research knowledge to tease apart the science on probiotics. Dr. Patno holds a PhD in Molecular Metabolism and Nutrition and has designed and monitored clinical trials on microbiome and immune health. Together, we dive into the latest evidence on therapeutic uses of specific probiotic strains, including Lactobacillus rhamnosus GR-1, for women’s health and other conditions. Dr. Patno also shares excellent pearls on dosing, duration, delivery methods and antibiotic resistance. Many thanks to Noelle and the team at Metagenics for always leading the way and researching interventions. Appreciate you listening, sharing, and commenting, and always, thanks for subscribing. - DrKF

Hormone therapy is still a highly controversial topic, fraught with lots of emotion, fear, and misleading information. And let me tell you: am I glad to be having a deep dive into the literature with my colleague and friend, the very brilliant Dr. Doreen Saltiel from Precision Analytical. She’s been practicing medicine for 40 years and preventative cardiology for more than 25 years. With advanced training in endocrinology as well as metabolic, anti-aging, and nutritional medicine, Dr. Saltiel is a leading expert on male and female hormone health. In this episode of New Frontiers, she brings her talent of dissecting the scientific evidence on testosterone deficiency and shares excellent clinical pearls to guide both physicians and patients in making decisions around hormone therapy. Folks, you’ll want to bookmark this one and save the show notes. Thanks for reading, sharing, and commenting! ~DrKF

Folks, in this exciting episode of New Frontiers we touch upon topics very close to my heart – genetics, epigenetics, kids, and why the heck they are so hard to raise! Brilliant professor of psychology and research scientist Dr. Danielle Dick shares guilt-banishing parenting strategies and her incredibly liberating research findings on genetics, temperaments, and child development. As an award-winning expert with over 350 scientific publications, Dr. Dick does an excellent job dispelling some deeply-rooted parenting myths and provides evidence-based approaches to understanding children and supporting their development. I can’t wait to get my hands on her new book The Child Code which contains many awesome resources and practical tips, including questionnaires on children’s temperaments and their genetically-influenced dispositions. To all the parents and caregivers out there – this one’s for you! Please share and leave a review to let me know what you think! ~ DrKF

Interest in therapeutic use of psychedelics has grown exponentially in recent years. And with recent studies showing these miraculous molecules help with depression, anxiety, and substance abuse, is it any wonder the p-word is on everyone’s lips? In this unique episode of New Frontiers, the fantastic Dr. Austin Perlmutter guest hosts and interviews renowned psychedelics researcher Dr. Anthony Bossis, clinical assistant professor of psychiatry at NYU and the NYU Center for Psychedelic Medicine. With decades of experience in psychedelic and palliative care research, Dr. Bossis shares an evidence-based deep dialogue on meaning-making, spirituality, and end-of-life care. Tune in to learn how psilocybin can lower depression, anxiety, and end-of-life suffering, the appropriate intervention steps to avoid “bad trips,” what cancer patients define as their most meaningful experiences – and so, so much more. It’s a podcast packed with powerful insights on the human race’s quest for meaning and finding our true selves in a world full of distractions. Can’t wait to hear what you think! ~DrKF

We are living in times of great medical discoveries and advancements and today I am thrilled to talk about a relatively unknown structure: the endothelial glycocalyx (EGX). EGX can profoundly affect overall health – after all, you can’t have healthy organs and tissues if blood vessels are not healthy. Today on New Frontiers, I am joined by Dr. Kristine Burke a board certified family, sports and functional medicine physician and medical director for Help Your Diabetes Sacramento, where we discuss the full breadth of EGX functions and why it’s critical for cardiovascular health and so much more. Dr. Burke shares her exciting clinical experience and impressive findings from her case study series using Arterosil for plaque regression in some of her toughest patients. It’s a fascinating and enlightening conversation, so tune in and get ready to take some notes! Thanks for listening, and your support of New Frontiers. -DrKF

With an ongoing pandemic that doesn't abate, is it any wonder immune health is on everyone's mind? As we adapt to these unprecedented times, the interest in supporting immunity has skyrocketed. So, I couldn't wait to interview my dear friend and long-term colleague, Romilly Hodges. With her new book Immune Resilience just out, I'm thrilled to share Romilly's exciting pearls on immune health on New Frontiers. You may know Rom from her time as Nutrition Programs Director at our clinic and her work on our Methylation Diet & Lifestyle program, now known as Younger You. Romilly is all that, and so much more: also a CNS, IFMCP, and vastly published author in several peer-reviewed journals. In this very special episode, we discuss the role of the microbiome in infection defense and immune system training, the effects of nature exposure, the ongoing pandemic and immune system development, immune tolerance and micro-exposures, and how sleep affects vaccine efficacy. It’s a lot! Romilly also reveals strategic multifactorial interventions and the power of whole foods over supplements. This research-packed discussion will leave you wanting more – to be continued for sure! As always, thank you for listening and please do leave a comment wherever you hear my voice. - DrKF

Folks, I'm thrilled to be back once again with my friend and colleague, Dr. Tom Fabian - leading functional nutrition practitioner trained in the molecular biology of aging. Together with his training and experience as the clinical laboratory consultant for Diagnostic Solutions Lab, Dr. Fabian shares a wealth of practical applications for microbiome research in functional medicine and clinical settings. In this episode, we explore key microbial species for longevity and how to boost their levels, inflammaging of the microbiota, often-missed leaky gut clues on GI-MAP reports, the small intestine as a key site for immune tolerance, how microbiota influence epigenetics, and much more. It’s truly exciting to learn from his extensive research expertise in the role of the human microbiome in health, disease, and aging, so make sure you get ready to take notes and bookmark this page – you’ll want to come back for more! Thanks for listening, and leave us a review wherever you listen to New Frontiers! ~DrKF