Targeting Senescent Cells? Dose and Timing Matters - with Dr. Greg Kelly

Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF <ul> <p>Head over to <a href="https://www.drkarafitzgerald.com/fxmed-podcast/">https://www.drkarafitzgerald.com/fxmed-podcast/</a> for all the full transcription and all relevant links and resources.</p> <p><strong>Guest information</strong></p> <ul> <li>Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift.</li> <li>Email: [email protected]</li> <li>Facebook: <a href="https://www.facebook.com/neurohackercollective">https://www.facebook.com/neurohackercollective</a></li> <li>Instagram: <a href="https://www.instagram.com/neurohacker/">https://www.instagram.com/neurohacker/</a></li> <li>LinkedIn: <a href="https://www.linkedin.com/in/gregory-kelly-98b96b138/">https://www.linkedin.com/in/gregory-kelly-98b96b138/</a></li> </ul> <p><strong>Qualia Discount for New Frontiers Listeners</strong></p> <p>If you’re in your late 20’s or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to <a href="https://tinyurl.com/4mst9py9" target="_blank">https://tinyurl.com/4mst9py9</a> for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase.</p> <ul> <li>Dr. Gregory Kelly: <a href="https://neurohacker.com/people/greg-kelly">https://neurohacker.com/people/greg-kelly</a></li> <li>Neurohacker Collective: <a href="https://tinyurl.com/3zpsaw3s">https://tinyurl.com/3zpsaw3s</a></li> <li>Shape Shift: <a href="https://tinyurl.com/3zpsaw3s">https://tinyurl.com/3zpsaw3s</a></li> <li>Alternative Medicine Review: <a href="https://tinyurl.com/56ad9av9">https://tinyurl.com/56ad9av9</a></li> <ul> <li>OMEMI Trial - <a href="https://pubmed.ncbi.nlm.nih.gov/33191772/">https://pubmed.ncbi.nlm.nih.gov/33191772/</a></li> <li>REDUCE-IT Study - <a href="https://clinicaltrials.gov/study/NCT01492361">https://clinicaltrials.gov/study/NCT01492361</a></li> <li>ASCEND Study - <a href="https://ascend.medsci.ox.ac.uk">https://ascend.medsci.ox.ac.uk</a></li> <li>VITAL Study - <a href="https://www.vitalstudy.org/">https://www.vitalstudy.org/</a></li> <li>Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - <a href="https://tinyurl.com/2p85yx5f">https://tinyurl.com/2p85yx5f</a></li> </ul> <p><strong>DrKF Resources</strong></p> <p>Patient consults with DrKF physicians including Younger You Concierge: <a href="https://www.drkarafitzgerald.com/our-clinic/our-services/">https://www.drkarafitzgerald.com/our-clinic/our-services/</a></p> <p>Bio Age Lab Test: <a href="https://youngeryouprogram.com/bio-age-lab-test/">https://youngeryouprogram.com/bio-age-lab-test/</a></p> <p>Bio Age Self Assessment Quiz: <a href="https://youngeryouprogram.com/basa/">https://youngeryouprogram.com/basa/</a></p> <p>Younger You Group Program: <a href="https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/">https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/</a></p> <p>Younger You book: <a href="https://youngeryouprogram.com/book/">https://youngeryouprogram.com/book/</a></p>