Mitigating Muscle Loss from GLP-1 Agonists, with Dr. Anurag Singh

<p><strong>Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity.</p> <p>In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF</p> <p>Check out our show notes <a href="https://www.drkarafitzgerald.com/fxmed-podcast/">https://www.drkarafitzgerald.com/fxmed-podcast/</a></p> <h3>Guest information</h3> <p><strong>Anurag Singh, MD, PhD</strong><br>Chief Medical Officer at Timeline</p> <h3>Thank you to our sponsor</h3> <ul> <li><a href="https://tinyurl.com/4npjcvjf">Timeline</a></li> <li><a href="https://tinyurl.com/ypfjws2e">Mitopure</a></li> <li><a href="https://tinyurl.com/53p6yjc9">Research from Timeline</a></li> <li>[email protected]</li> </ul> <p><strong>Timeline Discount for New Frontiers Listeners</strong><br> Timeline is offering DrKFs readers a 10% discount on Timeline products. Head over to <a href="https://tinyurl.com/4npjcvjf">Timeline</a> and use the code KARA10 at checkout.</p> <h3>Show Notes</h3> <ul> <li>Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity <a href="https://tinyurl.com/y3c2ypkw">https://tinyurl.com/y3c2ypkw</a></li> </ul> <li>Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55>= Years Old...<a href="https://tinyurl.com/bdzfccr8">https://tinyurl.com/bdzfccr8</a></li> </ul> <li>Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults <a href="https://tinyurl.com/2p9pjpxc">https://tinyurl.com/2p9pjpxc</a></li> </ul> <li>Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance <a href="https://tinyurl.com/2jkhmu9w">https://tinyurl.com/2jkhmu9w</a></li> </ul> <li>Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis <a href="https://tinyurl.com/mvrjxxsm">https://tinyurl.com/mvrjxxsm</a></li> </ul> <li>Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial <a href="https://tinyurl.com/fscfdd85">https://tinyurl.com/fscfdd85</a></li> </ul> <li>Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population <a href="https://tinyurl.com/e6npdvyp">https://tinyurl.com/e6npdvyp</a></li> </ul> <li>Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials <a href="https://tinyurl.com/2m2nzd56">https://tinyurl.com/2m2nzd56</a></li>