The Joe Cohen Show

What’s the difference between genomics and genetics? How important is it to understand your genes when looking at optimizing your health? In this episode, Dr. Anil Bajnath and Joe delve into the world of DNA and their impact on our health. Dr. Bajnath breaks down complex health science concepts in a way that's easy to understand, while sharing his unique approach to healthcare. Some highlights of the episode include: ✔️ Understanding the difference between genomics (the study of all genes in our body) and genetics (the study of inherited traits). ✔️ The role of transcriptomics (how our genes behave) in understanding health issues like PTSD. ✔️ The impact of our gut health on our overall wellbeing. ✔️ The potential dangers of over-reliance on certain medications like statins. ✔️ The relevance of understanding lipid dynamics (how fat works in our bodies) for our heart health. ✔️ The value of a holistic approach to healthcare - focusing on treating the whole person, not just symptoms. Dr. Anil Bajnath is a Board-Certified Family Physician. Author of The Longevity Equation: The Step-By-Step Blueprint to Hack Your Genes, Optimize Your Health, And Master the Art of Existence. Dr.Bajnath currently serves as Adjunct Faculty with the Department of Clinical Research and Leadership at George Washington University School of Medicine. He is the CEO and founder of the Institute for Human Optimization Precision Medicine Research Group located in Annapolis, Maryland. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Are supplements as strong as drugs? Dr. Tyler Panzner is this episode's guest, bringing his expertise on the role of genetics and supplements in combating common ailments such as IBS, anxiety, and insomnia. As a champion for understanding our body’s pathways, Dr. Panzner's approach is transforming our understanding of chronic disease and health management. Dr. Panzner dives deep into the crucial topic of understanding and supporting our body’s most commonly mutated pathways, rather than getting caught up in an endless cycle of supplementing every gene. He also provides an exciting viewpoint, comparing gene mutations and their effects across all cells in the body. Joe and Tyler also point out the potential risks associated with the use of supplements and discuss the importance of understanding how they affect our bodies. Dr. Tyler Panzner is a Ph.D. scientist trained in pharmacology, cancer, neuroscience, and inflammation research who has had a lifelong passion for understanding how substances affect the body. While his scientific training spans well over a decade, his passion for genetics and personalized medicine started ~6 years ago and he's pursued his goal of personalizing vitamin, supplement, and lifestyle regimes for each individual. - Follow @drtylerpanzer on Instagram - visit www.drtylerpanzner.com - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Vince Giuliano is back, and this time, he’s discovered something about aging that may blow your mind. Vince Giuliano is living a healthy and active life at the young age of 93, and is committed to continue doing research on longevity and increasing lifespan even at this age! In this episode, Vince Giuliano and Joe discuss how supplements truly affect aging and how Vince has changed his perspective on longevity and the factors that affect it. Vince talks about his new theory, which compares the human body to a computer system, and shares how you can hack your body from the “virus” that is aging and live a healthy and optimal life at an old age. Vince Giuliano was a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and COO of Mirror Systems, a software company, and an international Internet consultant. In various ways, he contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s, and is now engaged in doing the same for The Longevity Revolution. He has published over 200 books and papers as well as over 430 substantive entries in his blog. - Find Vince Giuliano’s work at agingsciences.com - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

In this episode, Joe sits down with biohacker and health expert, Anthony DiClementi. Best known for his revolutionary work in the biohacking space, Anthony shares a wealth of knowledge drawn from his 20+ years of experience biohacking himself and his clients with biohackingcoach.com. Anthony highlights the surprising, often overlooked factors contributing to bad health in the US, particularly focusing on the hidden toxins in our foods, the way cities are built, and the culture surrounding social interactions. This engaging conversation also delves into the dichotomy of medical practice and nutritional wellness, highlighting how conventional treatments often fail to address core health issues. Joe and Anthony also discuss the importance of genetics in understanding sensitivities to environmental toxins, and discuss the current landscape of DNA companies. This episode of The Joe Cohen Show is a must-watch if you're looking to enhance your understanding of the unseen triggers impacting your health and wellness, and what you can do to completely optimize your health.

In this episode of The Joe Cohen Show, Joe sits down with Chief Scientific Officer of MitoQ, Dr. Siobhan Mitchell. Siobhan shares her impressive academic and industry experience and knowledge to explore mood, cognitive function, and mitochondrial health. Her industry experience includes giants like Unilever, Nestle, PepsiCo, and Noom, where she worked on the fascinating effects of nutrition on mood and cognition. Siobhan and Joe do a deep dive into the serotonin-mood connection, helping us understand the genetic risk factors for depression and anxiety. Siobhan also shines a light on the underestimated significance of brain energy to mood and how mitochondrial strength plays a key role in this context. Siobhan also demystifies oxidative stress misconceptions and explains the impact of targeted antioxidants such as COQ10 and MitoQ. Finally, we delve into the 'Ozempic' effect of fiber on our gut health and how it could suppress your appetite naturally. Siobhan illustrates her firm belief that understanding the food we consume can prevent numerous diseases - truly, food is our medicine. Explore these topics and much more as we discuss the human brain, mood, and the pioneering research in the field of mitochondrial health. - Visit mitoq.com - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Intro (1:31) - Serotonin & Mood (12:56) - Brain Energy and mood (16:53) - Oxidative Stress & Muscle Growth (23:14) - Supplements that reach the brain (28:51) - CBT, physiology, and mood (32:00) - What are isoflavones? (38:43) - Difference between SSRIs and Tryptophan or 5HTP (50:04) - Brain energy and mitochondria health (56:15) - Fiber, Butyrate, and the Ozempic Effect (1:02:53) - Favorite probiotics (1:04:14) - Deep dive into fish oils (1:09:16) - Siobhan’s supplement stack

How can you use your biomarkers to create the optimal diet and supplement regimen for YOU? In this episode, Ari and Joe discuss how, similar to DNA, even optimal lab levels are personalized based on your unique body. Ari talks about the problem with only focusing on 1 biomarker, and lets you in on important things to look out for when optimizing energy and focus. They discuss the importance of AI and big data to health, and discuss the growing wearable market and how big of an impact this will have on optimizing health now and in the future. Ari and Joe also discuss the importance of sleep and how it affects your recovery, and Ari shares his ultimate regimen for optimal sports performance. Ari Tulla is a San Francisco-based entrepreneur and the co-founder & CEO of the smart nutrition service, Elo, whose mission is to transform food from the leading cause of disease to medicine. Ari is also an active angel investor and advisor with a portfolio of 40 startups, including Virta Health, Good Eggs, and Ōura. - Visit elo.health - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Intro (2:24) - Important biomarkers to test for (10:33) - HbA1C and Glucose hacks (29:40) - Homocysteine and the growing science behind it (39:01) - Is there one blueprint for optimal health? (46:50) - Sports performance vs. training for longevity (1:02:13) - Sleep and HRV (1:11:24) - The growth of health technology (1:20:44) - Biological age tests (1:26:55) - How to improve sleep

This episode was originally published on April 18th, 2017 on SelfHacked Radio - now known as The Joe Cohen Show. It's been 6 years since this episode aired, and yet a lot of health issues that were mentioned, alongside revolutionary health strategies that Dr. Gundry shares, are still more relevant than ever! In an episode that clearly shows Dr. Gundry was way ahead of his time, Joe and Steven Gundry discuss the prominence of leaky gut, how inflammation is the cause of the majority of health issues, and the root cause of all of this - LECTINS! You'll also discover the best ways to approach an elimination diet and how to optimize your gut health! - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram Timestamps: (0:00) - Intro (15:52) - Lectins number one cause of gut issues? (22:15) - TH2 dominance and the immune system (27:55) - The process of healing your gut to introduce more foods (31:49) - Starting with a lectin-free diet (34:17) - Fiberous carbs vs non-fiberous carbs (44:17) - Low histamine foods relation to lectins (48:00) - The cannabinoid system and the CNR1 Gene (52:48) - Best probiotics to restore the gut (55:52) - Most important supplements to take (58:56) - Keto Plant Paradox (1:01:47) - Animal protein and mTOR

Does a fast-mimicking diet give you the same benefits as a 5-day water fast? How important is periodic fasting - also known as prolonged fasting - to your health? What is the best length of an intermittent fast? In this episode of The Joe Cohen Show, we dive deep into the world of fasting with our guest Dr. Joseph Antoun from L-Nutra, the pioneering company behind the revolutionary fast-mimicking diet. We discuss the science and mechanisms behind the fast-mimicking diet, exploring how it allows you to consume food and trick your body into thinking it’s fasting! Dr. Antoun also shares his thoughts on the best time to stop eating, how long your intermittent fast should be, and how these practices can improve your longevity. Dr. Joseph Antoun is CEO & Chairman of the Board of L-Nutra and Member of the Forbes Business Development Council. He's the former CEO of Health Systems Reform, a boutique consultancy aimed at improving public health by reforming health systems, management, and delivery. - Discover fasting at L-nutra - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (1:48) - Longevity and fasting (7:10) - Fasting by nourishment vs. deprivation (13:06) - Periodic fasting vs. intermittent fasting (15:41) - Eating while fasting (21:37) - The structure of a fast mimicking diet (25:03) - Mimicking an intermittent fast (25:43) - The mechanisms behind fasting

Have you ever wondered what separates elite athletes and Navy SEALs from the rest of us? How do they optimize their physical and mental performance? In this episode, Andrew Herr - who has led human performance and biotech strategy efforts for the U.S. military and ran R&D strategy efforts to get Navy SEALs ready to deploy - comes on the show to share his secrets to hack your recovery, improve your cognitive function, and optimize your stress management techniques. Plus, Andrew talks about the biological causes of jet lag, and how you can solve jet lag in less than a day! Some highlights of the episode include: ✔️ The one mistake even elite athletes make that might be wasting up to 50% of your workout value ✔️ Stress management techniques to improve your overall health ✔️ What supplements you can take to improve cognitive performance ✔️ The best thing you should focus on to enhance physical performance Andrew is the Founder & CEO of Fount. Fount runs the most comprehensive and customized health and performance programs in the world and has discovered full solutions to challenges like jet lag and PMS. Over the past decade, Andrew led human performance and biotech strategy efforts for the U.S. military, from running R&D strategy efforts to getting Navy SEALs ready to deploy. This background has made him a trusted adviser to pro sports teams, leading corporations from tech to finance, and world class scientific institutions. - Discover fount.bio - Find fount on instagram @fountbio - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Intro (1:53) - Andrew's journey with the Navy SEALs (6:33) - Stress management techniques (15:20) - Optimizing gut health (28:26) - Thoughts on cholesterol (36:18) - Improving cognitive performance (38:15) - Improving physical performance (43:46) - Optimal ApoB numbers (48:27) - Solving jet lag

Is cholesterol good or bad for you? How should you treat your serum cholesterol levels in the blood? Is LDL-C the best marker to look at when analyzing your cardiovascular health? In this episode, Joe dives deep into the complex and controversial world of cholesterol, examining the ongoing debate around its impact on cardiovascular health. First, he breaks down the different viewpoints that dominate the topic of cholesterol, discussing the positives and negatives of each one. He also delves into various factors contributing to cardiovascular disease and how cholesterol fits into the bigger picture. Then, he explores 10 lesser-known benefits of lipoproteins and cholesterol, including cellular repair, hormone production, mood improvement, and more. Joe explains the different markers we should consider when assessing cardiovascular risk, such as non-HDL Cholesterol, ApoB, and LDL particle size. Finally, Joe shares his own experiences and offers his own approach on how to deal with cholesterol on a personalized level. Check out SelfDecode Join Joe’s online community Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (01:09) - The cholesterol wars (02:55) - 10 Benefits of lipoproteins (10:46) - The tricky issues of cholesterol (18:11) - LDL, ApoB and Cardiovascular Disease (22:30) - The increase in evidence since 2015 (25:25) - Does lower cholesterol always mean better? (29:49) - Looking at the big picture

Do you ever feel like you're walking on a tightrope, unsure of what foods might trigger an unwanted reaction? Well, you're not alone. Food sensitivities are more common than ever, and they can cause a whole host of issues ranging from digestive discomfort to brain fog. After years of research and experimentation, and with the help of SelfDecode, Joe found what he think is a break through in reversing food sensitivities. Now, he can eat things that he never thought possible a few years ago. So he’s decided to share his journey and discoveries with you in this episode. He dives deep into the world of food sensitivities, sharing some life-changing insights that equip you with the tools you need to overcome your own food sensitivities. Some highlights of what you'll discover in this must-listen episode: The mechanics behind food sensitivities and how they affect your body Joes tried-and-tested top 5 hacks for improving food sensitivities (featuring some surprising nutrients you might not have considered!) The magic of butyrates and how they can transform your relationship with food The connection between tryptophan, ApoB, and your ability to enjoy a wider range of foods Check out SelfDecode Join Joe’s online community Follow Joe on Instagram & TikTok

How important is it for you to test and track your lab markers? Are some tests more important than others? Are functional lab tests useless, or is it just the way that companies are interpreting the data that renders it useless? In this eye-opening episode, we brought on Dr. Chris Masterjohn and Dr. Tommy Wood to dive deep into understanding the complexities of test results, vitamin and mineral deficiencies, and genetic predispositions. Chris and Tommy use their years of expertise and tremendous depths of knowledge in the health space to discuss the issues with alternative health tests and the best ways to utilize your DNA results. They also discuss the effects of deficiencies on essential nutrients like zinc and how you can take control of your well-being by identifying unique deficiencies about your own body. Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health. Dr. Tommy Wood is an MD with a Ph.D. in physiology and neuroscience. He has coached world-class athletes and is currently an Assistant Professor of Pediatrics and Neuroscience at the University of Washington. - Find Dr. Tommy Wood on Instagram - Find Chris on Instagram - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Intro (9:58) - Repeatability in testing (18:28) - Validity of urine hormone testing (31:00) - Chris’ thoughts on organic acids tests (39:03) - Validity of organic acids tests (43:52) - Fungal & yeast tests (47:11) - Going over relevancy of some markers (54:25) - Polygenic Risk Scoring (1:00:47) - Nutritional Markers (1:05:20) - Neurotransmitter Markers (1:07:10) - Stool IgA Tests (1:12:10) - Ion Amino Acids Panel (1:16:51) - Summarizing functional lab tests

To celebrate the end of Season 2, we’ve gathered the top 10 moments of The Joe Cohen Show and compiled them into a single podcast episode! These moments were voted on by Joe, employees of SelfDecode, and listeners of The Joe Cohen Show. It includes clips filled with valuable knowledge on different health topics and actionable takeaways that you can implement in your daily life. Full The Joe Cohen Show Episode links: Stacy Sims Dominik Nischwitz Richard Miller Molly Maloof Chris Masterjohn Alex Leaf Jeffrey Gladden Carrie Jones Vince Giuliano Tommy Wood Timestamps: (0:00) - Intro (0:18) - Stacy Sims (7:38) - Dominik Nischwitz (13:50) - Richard Miller (19:08) - Molly Maloof (26:58) - Chris Masterjohn (30:09) - Alex Leaf (33:41) - Jeffrey Gladden (42:04) - Carrie Jones (47:45) - Vince Giuliano (51:24) - Tommy Wood - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Longevity is a concoction of many different things - VO2 max, HRV, telomere length, blood pressure, mTOR and AMPK, and so much more. Optimizing and improving your lifespan requires a balanced focus on all of these through lifestyle, diet, and supplement implementations. Dr. Jeffrey Gladden - a Board certified interventional cardiologist and the founder of Gladden Longevity - is the guest of today's episode! We explore the different strategies that claim to improve longevity and dive deep into the science behind specific exercises, supplements, and drugs that improve lifespan. Jeffrey talks about the ways to master your metabolism by utilizing the economy of balance concept, discusses all the different ‘biological ages’ that can be used to interpret our health, and gives his tip on the best way to increase VO2 max. Dr. Jeffrey Gladden is a Board certified interventional cardiologist and the founder of Gladden Longevity, Human Performance & Longevity Optimization. He did his undergraduate work at Wheaton College and earned his Doctor of Medicine degree with Honors from Temple University in 1982. He has specialized in many areas of cardiology, including interventional, diagnostic, preventative, and programmatic. - Find Dr. Jeffrey Gladden at https://gladdenlongevity.com/ - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

In our Health Analysis Series, Joe Cohen, expert biohacker and founder of SelfDecode, brings on a guest, and together they utilize the power of DNA and labs to assess, discuss, and recommend ways to further optimize their health. Our guest today is Briana Theroux, a health professional certified by the Institute for the Psychology of Eating who has over a decade of experience biohacking her health. In episode 2 of this 2 part series, Joe and Briana analyze her DNA results on SelfDecode, as well as her current and past lab markers. They then discuss Briana’s current supplement stack, going in-depth on why each supplement is chosen and how it impacts her health. Finally, they discuss ways that they can further optimize her health based on her genetic predispositions and lab markers - giving you the perfect outline on how you should approach your health! This is the final episode of our Health Analysis Series. - Find Briana on Instagram @liftheavybreatheeasy - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

In our Health Analysis Series, Joe Cohen, expert biohacker and founder of SelfDecode, brings on a guest, and together they utilize the power of DNA and labs to assess, discuss, and recommend ways to further optimize their health. Our guest today is Briana Theroux, a health professional certified by the Institute for the Psychology of Eating who has over a decade of experience biohacking her health. In episode 1 of this 2 part series, Briana goes over her health history, discusses some of the game-changing supplements and lifestyle changes she has done to overcome her health issues, and dives deep into some tips and tricks for biohacking as a woman. This episode provides the foundation for the next episode, where Joe and Briana look at genetic predispositions and lab levels to brainstorm the next steps to optimal health. - Find Briana on Instagram @liftheavybreatheeasy - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Biological age is a critical indicator of our overall health and wellness. It's a measure of how well our body functions compared to others of the same chronological age. But are all biological age tests the same? Are some more accurate indicators than other? In this episode, Alex Leaf and I discuss the lifestyle factors that contribute to biological aging, such as diet, exercise, and stress management, and how we can make changes to improve our health and wellbeing. We also talk about body image and its connection to mental health, and Alex shares his thoughts on Agmatine as well as his top 10 supplements. Alex Leaf, M.S., holds a master’s degree in nutrition from Bastyr University and has been writing about the science of nutrition, health, and fitness for over a decade. Currently, Alex is a content creator and research writer alongside Ari Whitten at The Energy Blueprint. Formerly, Alex was a senior researcher at Examine.com and teaching assistant for the University of Western States' Human Nutrition and Functional Medicine masters program. - Find Alex at www.alexleaf.com - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Optimal nutrition is different from person to person, and even moreso from sex to sex. Men and women have many physiological differences that can truly change how to approach your health and fitness. Are cold plunges good for men and women? What about saunas? Dr. Stacy Sims - a forward-thinking international exercise physiologist and nutrition scientist - is the guest of todays episode, and we explore the physiological differences between male and female bodies and reveal how you can optimize your nutrition and training based on your unique needs. We dive deep into specific vitamins and minerals, the difference in heat retention and how that affects health, and we discuss whether some biohacking methods - like cold plunges and saunas - are more optimal for one sex. Stacy Sims has directed research programs at Stanford, AUT University, and the University of Waikato, focusing on female athlete health and performance and pushing the dogma to improve research on all women. Her contributions to the international research environment and the sports nutrition industry has established a new niche in sports nutrition; and established her reputation as the expert in sex differences in training, nutrition, and health - Find Stacy on Instagram @drstacysims - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

What are some steps that you can take to boost your immune system so that you can stop getting sick? What if you just started feeling some symptoms, are there specific supplements that will stop the sickness dead in its tracks? Dr. Chris Masterjohn is back on the podcast to outline his Ultimate Cold Prevention Protocol! In this episode, Chris and Joe go through all of Chris’ prevention protocol - starting with what to do to strengthen your immune system, to your action plan when you first experience the “suspicous sneeze”, to what different vitamins and minerals you should focus on when you’ve been infected. Chris also discusses the importance of understanding scientific studies (it’s more than just looking at charts), the difference between focusing on deficiencies vs. optimization, and his thoughts on alternative health tests like organic acids and dutch tests. Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health. - Find Chris on Instagram - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (1:00) - Chris’ thoughts on functional tests (23:52) - Deficiency vs. Optimization (29:30) - The immune system (35:34) - The cold prevention protocol (41:58) - The importance of understanding studies (44:53) - Explaining Vitamin D (48:59) - Continuing the cold prevention protocol (56:07) - Nutrients for immunity (1:07) - Glutathione

What supplements should I take to improve my hormones? Is there an optimal balance of estrogen and progesterone? Is prolactin an important hormone for men? Hormones are an extremely important part of optimizing your health, but the majority of people have no idea just how much of an impact they have on… well, everything. An estimated 30% of women experience hormone imbalances, which can cause mental health issues, weight issues, fertility, and much more. That is an absolutely insane number! So, I brought on Dr. Carrie Jones for this podcast to discuss all things hormone health and the growing studies that are helping put the spotlight on this important health area. In this episode, Carrie shares the best thing you can do to optimize your hormones (in her words: it’s not that sexy), and we dive into detail on the relationship between estrogen, progesterone, prolactin, cortisol, and more. We also discuss how these are important hormones to keep track of for men. - Find Dr. Carrie Jones on Instagram @dr.carriejones - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (1:31) - The difference between men and women (3:16) - How hormone cycle effects training (9:00) - Immune system and estrogen (12:41) - Estrogen and sleep (21:06) - Blood tests for hormones (30:31) - Cortisol, stress, and hormones (37:14) - Dopamine and prolactin (46:53) - How to optimize your hormones (51:30) - The best way to check your labs

How important is oral health to your overall health? What are you really doing when you remove your wisdom teeth? Turns out, bad oral hygiene is linked to a lot of chronic diseases, like heart disease, metabolic issues, depression and anxiety, and so much more. So how can you optimize your oral health? Dr. Dominik Nischwitz is on today’s episode to give you practical strategies that you can implement to improve your dental health and, through that, your overall health! In this episode, Dr. Nischwitz discusses the importance of maintaining optimal health in the mouth and highlights the key nutrients that you need to keep your teeth and gums in the best shape possible. He also shares tips to help with bad breath, whether you really need to floss, and if mouthwash is good or bad for you. And finally, he reveals his three superhuman oral healthcare strategies to keep your mouth healthy. Dr. Dominik Nischwitz is a dentist and naturopath, a world specialist in biological dentistry and ceramic implants and the current Vice-President of the International Society of Metal-free Implantology (ISMI). A pioneer in the field of holistic dentistry, Dr. Nischwitz regularly gives lectures around the world and has recently published his first book “IT´S ALL IN YOUR MOUTH" at Chelsea Green. - Find Dr. Dominik Nischwitz on Instagram @drdome1 - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (1:35) - The importance of oral hygiene (15:52) - Improving teeth for the next generation (18:12) - Important nutrients for good dental health (26:25) - Dr. Dome’s Health Journey (30:15) - Optimizing your mood using genetics (34:40) - Circling back to dental health (37:23) - How important is flossing? (43:30) - Are mouthwashes good or bad? (44:34) - The three superhuman oral healthcare strategies (47:03) - The epidemic of bad breath and tongue diagnosis (51:56) - 5 tips to help with bad breath (57:22) - Dr. Dome’s thoughts on Niacin (1:03:56) - The effects of antibiotics (1:06:53) - The issues with cavitation - the silent inflammation (1:10:26) - Thoughts on fluoride and dentist teeth cleaning

It’s hard to slow down when you’re dopamine-dominant. Being highly motivated, fast-paced, and competitive has many benefits, but how can you slow down when it starts negatively impacting your health? Kris Gethin is on the podcast today to answer that, and much more! In this episode, Kris and Joe discuss their thoughts on stem cell therapy, how to choose what supplements to add and remove for optimal fitness, and how Kris uses biohacking to balance his training with his focus on living a long and healthy life. Kris also gives us an inside look at his daily routine and what he focuses on to optimize his diet and nutrition, which has resulted in him achieving a glycan age of 26 at the current chronological age of 48! Kris Gethin is the co-owner of KAGED supplements, co-owner of the Kris Gethin Gyms, owner of Kris Gethin coaching and a hybrid athlete. He is the former editor in chief of bbcom, former editor at large of FLEX and came 2nd in Natural World bodybuilding championships in 2006. - Find Kris Gethin on Instagram @krisgethin - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (2:56) - Kris’ Daily Routine (10:42) - How Kris chooses his supplements (15:24) - HRV and training (21:18) - The neurochemistry behind overtraining and mood (26:13) - Kris labs and supplements (31:34) - Stem cells (33:50) - Longevity and bodybuilding (42:36) - How to improve glycan age (45:43) - Th1 vs Th2 and megadosing supplements

As more people start focusing on their health, personalized nutrition is growing. But it’s important to make sure that you understand what personalized diets entail, and how you can take the right steps to build the best nutrition plan for you. The best person to help you get started? Dr. Chris Masterjohn, who earned his PhD in Nutritional Sciences in 2012 and has been deeply entrenched in the research for 20+ years! In this episode, Chris Masterjohn and Joe discuss issues with the RDA (Recommended Dietary Allowance), the differences in how they tackle health issues that come their way, and Chris outlines the steps he takes to discover the best supplements that improve his overall health! Chris talks about how his battle with mold toxicity, how he solved a twitching problem, and his current experiment with a supplement that he thinks will be game changing for his health. Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health. - Find Chris on Instagram - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

How important is mitochondrial function in increasing energy? Is intermittent fasting different for men and women? Is metabolic health being overlooked in the USA? In this episode, Dr. Molly Maloof and Joe discuss how important it is to focus on your mitochondrial health, and Molly gives her TOP suggestions to condition your mitochondria for optimal energy and health! Molly talks about the epidemic that is metabolic diseases, and discusses the best way to structure your exercise schedule as a woman. They also discuss the significance of continuous glucose monitors, what it means to have good lab levels, and specific biohacks to improve HRV. Dr. Molly Maloof’s book THE SPARK FACTOR: The Secret To Supercharging Energy, Becoming Resilient, and Feeling Better Than Ever is on sale January 31st! As a physician and Stanford lecturer, Dr. Molly Maloof has spent her career providing personalized medicine services to high-performing technology executives, billionaire investors, Silicon Valley entrepreneurs, and Academy Award-winning actors. - Preorder Molly’s book: “The Spark Factor” - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (3:38) - Molly's daily routine & sleep schedule (13:14) - Molly's supplement stack (16:52) - Controversy surrounding IV NADs (21:08) - Optimizing mitochondrial health (29:51) - Oxytocin & human connection (38:19) - Intermittent Fasting (47:45) - CGMs and Hba1c (1:01:14) - Optimizing exercise based on the menstrual cycle (1:13:06) - What does it mean to have good lab levels? (1:19:24) - The epidemic of metabolic diseases (1:23:39) - Thoughts on psychedelics (1:26:32) - Thoughts on Ketamine (1:32:38) - Organic acids testing (1:36:02) - Does Molly take Nootropics?

The longevity revolution is upon us, as more and more studies are being done to discover ways to increase lifespan. One of the strongest advocates of this revolution? Vince Giuliano, living a healthy and active life at the young age of 93! In this episode, Vince Giuliano and Joe discuss how he’s made it into his 90s in tiptop shape, how he tackles health issues that come his way, and what he would have done differently if he can travel back in time. Vince talks about how he got his HRV levels to outperform young and healthy athletes, and shares some of his favorite supplements - specifically one that he has been taking for nearly 40 years! Vince also talks about non-supplemental ways that you can implement in your life to improve your health and increase your longevity. Vince Giuliano was a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and COO of Mirror Systems, a software company, and an international Internet consultant. In various ways, he contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s, and is now engaged in doing the same for The Longevity Revolution. He has published over 200 books and papers as well as over 430 substantive entries in his blog. - Find Vince Giuliano’s work at agingsciences.com - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (4:29) - When did Vince start his longevity journey? (5:33) - Vince’s supplement journey (18:08) - What Vince would do differently (22:40) - Thoughts on Rapamycin (31:27) - HRV & Heart Rate (33:00) - Near infrared devices (36:48) - More on Vince’s Supplement (45:04) - Vince’s Top 5 Supplements

How far along is the science of longevity, and are there already proven methods that can increase your lifespan? In this episode, Richard Miller and Joe discuss the massive strides that are happening in the longevity space, and Richard shares the six compounds that have very promising research backing their benefit in improving life expectancy! Richard talks about the problem with certain scientific studies and gives his thoughts on the controversial calorie restriction & longevity debate. They talk about all kinds of drugs, including rapamycin, acarbose, reservatrol, and more, and discuss the one OTC supplement that has positive effects on lifespan! Richard Miler is a Professor of Pathology at the University of Michigan, and Director of the Michigan Glenn Center on Aging. He got his MD and PhD at Yale, did postdoctoral work at Harvard and Sloan-Kettering, and was on the faculty at Boston University until his move to Michigan in 1990. - Find Dr. Richard Miller’s work at www.richmillerlab.com - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Joe and Dr. Tommy Wood go over the most popular alternative health tests to tell you which ones are worth it and which ones are not. Joe and Tommy discuss microbiome tests, organic acid tests, heavy metal tests, and so much more! Plus, find out the one occasion the Dutch test is helpful according to Dr. Tommy. Tommy also shares the difference between IgE vs IgG food sensitivity tests and which one you should stay away from. They discuss whether vitamins & minerals tests are reliable, and tell you the problem with the RDA. Find out what Tommy thinks about DNA tests, and why you shouldn’t try a health intervention based on a single SNP. Plus, Joe and Tommy discuss what’s the best approach when it comes to using genetic testing for health (spoiler: It’s polygenic risk scoring). Dr. Tommy Wood is an MD with a Ph.D. in physiology and neuroscience. He has coached world-class athletes and is currently an Assistant Professor of Pediatrics and Neuroscience at the University of Washington. - Find Dr. Tommy Wood on Instagram - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Find out Joe’s final 9 best supplements to improve mood! In this episode, Joe concludes his mood regimen of 18 supplements. Discover which supplements he’s been taking for years, and which two he’s thinking of removing from his regimen and why. Joe talks all about betaine, vitamin B12, L-theanine, and more, and shares how he analyzes his personal health data (including family history, lifestyle, and predispositions) to decide which supplements to take and their dosages. Joe also talks about why he cares about kidney health, and why you should too (spoiler: 90% of people who have kidney disease don’t know they have it). Plus, find out which mood supplement can surprisingly help with gray hair! Listen to Parts 1 and 2 to discover 9 more supplements that are part of Joe’s mood regimen! - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

What does a biohacker and a chef have in common? It may surprise you! In this episode, Joe continues to go through the supplements in his mood toolkit. He discusses 6 of his favorite supplements for mood, their mechanisms of actions, and effects. Plus, find out which supplement Joe would take if he couldn’t take 5-HTP. He explains why finding out he had a zinc deficiency was a game-changer for his health and mood, the benefits of a zinc supplement, and what you need to look out for to see if you need more of this essential nutrient. Learn more about the pros and cons of methylfolate, how to know how much you should take, and the surprising effects it has on fasting. Joe also talks about one of the biggest mistakes he did in the beginning of his health journey, and why he’s commited to doing research and experiments with all supplements in his regimen. Learn all about rhodiola, lithium orotate, and more! - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Find out what’s in Joe’s mood toolkit! Joe Cohen has been doing health experiments on himself for over 20 years, and he’s finally sharing all his knowledge with you. In this episode, Joe walks you through lifestyle changes and 3 of his favorite supplements for mood: 5-HTP, thiamine, and resistant starch & butyrate. He discusses his megadosing experiments, dosages, and his problem with the RDA. He explains why he takes each supplement, the mechanisms of action of these supplements, and the effects they have on his mood. Plus, discover the one problem Joe has with resistant starch. Find out how Joe determines if he’s deficient in a nutrient, and the importance of learning your genetic predispositions and tracking your labs when building your regimen. Learn all about Joe’s favorite mood stabilizer supplements! - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Have you heard of scientific wellness? In this episode, Nathan Price and Joe discuss whether the conventional approach of using pharmaceuticals to treat chronic diseases is effective, or if a preventative approach to complex conditions such as cardiovascular disease and Alzheimer’s is the best choice. Nathan explains how genes can help predict the success of lifestyle-based interventions and talks about the accuracy of polygenic risk scores vs single variants for disease prediction, and how genetics can be used in healthcare. Nathan and Joe also talk about nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), DHEA, and other supplements. Plus, Nathan explains the controversy of choline, carnitine, and TMAO, and if you should be worried. Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. He was named one of the 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine and was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine. - Preorder The Age of Scientific Wellness - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Should you be scared of psychedelics? In this episode, Tim Gray and Joe talk about how to get more REM and deep sleep, and Tim discusses his experience with methylene blue. They talk about the pros and cons of alcohol and their experience with different psychedelics. Tim shares his experience with conventional medicine, the top things he’s trying to optimize in his health and his strategies for kidney health, gut health, and more. He talks about how he used to track 35 biomarkers every day, and which ones he still continues to monitor. They discuss methylation, the MTHFR gene & SNPs, and how genetics and your environment can affect your overall health and how you respond to supplements. Tim Gray is the UK’s leading biohacker and the founder of the popular Health Optimisation Summit, The Biohacker London Meetup group, and London’s first private Hyperbaric Oxygen Clinic. He is dedicated health optimizing biohacker, a psychology specialist, entrepreneur, and global speaker. - Check out the Health Optimisation Summit (Use code SELFDECODE for 10% off your ticket) - Find Tim on Instagram - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Are supplements a waste of time and money? In this episode, Shawn Wells and Joe discuss whether taking supplements every day is bad for your health, and Joe shares the one time a supplement caused his liver enzymes to spike (it’s not what you’d expect!). Shawn talks about the problem with certain supplement companies and lets you in on important things to look out for when choosing a supplement. They talk about all kinds of supplements, including lipoic acid, dihydroberberine, paraxanthine, ergothioneine, NAD, and more, discussing their effects, dosages, and how they work in the body. Shawn and Joe also discuss the importance of optimal mitochondria function and why you should pay attention to it, and Shawn shares his ultimate mitochondrial supplement stack. Shawn Wells, MPH, LDN, RD, CISSN, FISSN, is the world’s leading nutrition biochemist and an expert on health optimization. He’s formulated over 700 supplements, foods, and beverages, and is the author of The Energy Formula. - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Do supplements work the same for everyone? In this episode, Lucas Aoun shares his favorite supplements to improve cognitive function and focus, and he and Joe dig deep into how these compounds work in the body, discussing the research, dosages, and what to look out for. They discuss dopamine and the mechanisms behind dopamine supplements and share their different experiences experimenting with supplements. Plus, listen to the benefits of increasing dopamine levels steadily vs taking supplements that cause a spike. Lucas and Joe also talk about how to optimize testosterone levels, what causes low testosterone, and Lucas shares one surprising hack to increase your testosterone levels. Plus, find out one health hack Joe coins as “bromeopathy”. Lucas Aoun is the founder of Ergogenic Health and Australia's leading biohacker & men's health expert. This interview is not intended as medical advice. - Find Lucas on YouTube - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram

Low carb? Keto? Low fat? Fasting? In this episode, Katie Wells and Joe talk about her experience with dieting, some of the benefits she gets from intermittent fasting, and they discuss the controversial topic of cholesterol (spoiler: lower is not necessarily better). Katie shares some of her favorite health hacks, and they talk about how genetics can influence a person’s health and how to use this information to live optimally. They also discuss which and how to track labs, the importance of optimal vs normal ranges, and what Katie does to hack her sleep & mood. Katie Wells is the founder and CEO of wellnessmama.com and wellnesse.com. A mom of 6, she took her health into her own hands and started researching to find the answers to her health struggles. She has written over 1,500 blog posts, 3 books, and was named one of the most influential people in health and wellness. This interview is not intended as medical advice. - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram Timestamps: (0:00) - Introduction (1:04) - How Katie got into health (3:53) - The Personalized Health Podcast? (4:57) - Shifting of health goals (6:44) - Katie’s current health goals (8:14) - Joe shares his health journey (9:04) - What labs to track for anti-aging? (10:32) - Alcohol and saturated fats affect on health (12:31) - Katie Wells thoughts on LDL cholesterol (13:24) - Over-dieting and under nourishing (16:52) - Unsullied by paid sponsors (17:18) - Megadosing and metabolic flexibility (18:45) - Katies daily supplement intake & fasting (20:01) - The mental and spiritual benefits of a long fast (22:15) - Joe’s experience with fasting (23:42) - What supplements does Katie take now? (24:39) - Pregnenolone dosages & benefits (25:40) - Nootropic stack for focus (26:37) - Tips to improve sleep from Katie (28:45) - Katie’s most successful health “experiments” (30:09) - The importance of protein in your diet (31:40) - The last time Katie changed her mind about a health topic (32:42) - The best health hack Katie wished she found earlier (34:52) - Katie’s top hacks to optimize mood (36:36) - The difference between normal and optimal lab ranges (37:45) - How using SelfDecode can help optimize your lab levels (38:58) - The most interesting DNA discovery (41:10) - Katie’s expectations on her life span (43:15) - Characteristics that make you successful

Is high cholesterol really bad for you? In this episode, Joe and Siim Land discuss what causes high cholesterol, which biomarkers to track for longevity, and the biggest mistake people make when trying to lose weight. Siim shares one surprising mineral that can help lower cholesterol and talks about how intermittent fasting helps his mental & physical performance. Then, Siim and Joe discuss a top supplement for longevity and healthspan. Siim Land is a renowned public speaker and expert in biohacking, health optimization, and overall performance optimization. He is also the author of Metabolic Autophagy and The Immunity Fix with Dr. James Dinicolantonio. This interview is not intended as medical advice. - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram Timestamps: (0:00) - Introduction (0:41) - Why Siim Got Into Biohacking (2:35) - What markers should you measure for longevity? (8:28) - Taking blood tests every year to track improvements (10:40) - The top supplement to improve longevity (13:21) - Unsullied by paid sponsors (13:47) - Cholesterol in the biohacking world (14:49) - Intermittent fasting, fats, and lowering cholesterol (17:30) - Zinc and Copper ratio (18:53) - Does lower T3 contribute to high cholesterol? (20:03) - One supplement with high evidence of increasing lifespan (21:00) - What Siim tracks on a regular basis (23:09) - Siim’s HRV numbers (24:20) - How Siim improves mental performance (26:51) - How Siim improves physical performance (30:35) - The biggest mistake people make with fat loss (35:21) - Genetics affect on portion control in diets (37:06) - How often is Siim physically active per day? (38:31) - How you process carbs differently based on your body composition (41:00) - Sleephacking tips from Siim Land (46:20) - Improving your immunity

Kiwi as a biohack for sleep? Bet you didn’t know that one! In this episode, Joe and Teemu Arina talk all about biohacking your sleep, low & high HRV ranges, why heart rate variability is important for your overall health, and discuss some of Teemu’s favorite biohacks for the body & brain. Teemu tells Joe why he got into biohacking, his secret to handling stress, and what he thinks is the best approach to optimizing his mental and physical performance. He also gives you a glimpse of what his supplement stack looks like and lets you in on one of his favorite supplements. Teemu Arina is a thriving speaker and the creator and organizer of the Biohacker Summit. He’s also the author of the Biohacker's Handbook: Upgrade Yourself and Unleash Your Inner Potential. This interview is not intended as medical advice. - Join Joe at the Biohacker Summit (Use code SELFDECODE10 for 10% off) - Check out SelfDecode - Follow Joe on Instagram Timestamps: (0:00) - Introduction (1:42) - How Teemu got into biohacking (7:43) - Optimizing the physical to improve the mental (10:10) - How to improve your creativity (13:03) - Personalizing your biohacking tools (21:18) - Unsullied by paid sponsors (21:45) - What is HRV and how Teemu increase his HRV (26:49) - What are Joe’s strategies for improving HRV (32:54) - The strength of the mind and negative effects of measuring (34:44) -  How the environment affects your sleep quality (36:38) - The best biohacks for sleep (41:00) - Melatonin’s effect on the body (42:51) - What supplements does Teemu take every day? (45:41) - Discount code for Biohacker Summit

Are EMFs harmful? Should you wear sunscreen? In this episode, Joe and Dr. Joseph Mercola discuss these and other controversial topics within the health industry. Dive deep into the importance of sun exposure (it’s not just vitamin D), vegetable oils, and learn valuable insights to hack your diet. Dr. Mercola shares his secret for better vitamin D levels, discusses the problems with linoleic acid and which foods to avoid, and talks about the one supplement he hasn’t taken in 15 years. Plus, listen to the top mistakes people make when trying to biohack their health. Dr. Mercola is a New York Times bestselling author and the founder of the natural health website Mercola.com, one of the world’s leading natural health website with millions of monthly visitors. Timestamps: (0:00) - Introduction (2:27) - The importance of the sun and Vitamin D (7:03) - Mendelian Randomization Studies with Vitamin D (10:20) - Dr. Mercola & The New York Times (11:45) - EMFs vs. Vaccines (14:25) - Tracking the effects of EMFs, Vegetable Oil, and Vaccines (15:32) - Unsullied by paid sponsors (16:00) - How long do the effects of Vegetable Oil last? (19:39) - The negative effects of Vegetable Oils (21:40) - What does Linoleic Acid do to your body? (26:34) - How Dr. Mercola changed his diet to remove vegetable oils and decrease linoleic acid (32:23) - Why studies on Vegetable Oil make it seem less harmful (34:06) - LDL Cholesterol levels (37:33) - The top 5 worst things people are doing for their health (44:37) - Iron, Ferritin, and Hemoglobin This interview is not intended as medical advice. - Check out SelfDecode - Follow Joe on Instagram