The Joe Cohen Show

In this episode, we explore the complex interplay between the CNR1 gene, cannabinoid receptors, and cannabis. Discover the role of the endocannabinoid system in maintaining bodily balance, particularly in brain function, mood regulation, and inflammation response. We delve deep into how genetic variations in the CNR1 gene can influence the CB1 receptors, and the implications of CB1 receptor function in managing stress, anxiety, and cognitive processes such as memory and decision-making. Whether you're curious about the science behind getting high or looking for ways to optimize your cannabinoid system through diet and supplements like CBD oil, this episode has something for everyone. If you're interested in learning more about how your DNA and genetics affect your health: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we explore the crucial role of serotonin in managing anxiety and enhancing mental wellbeing. Discover how serotonin not only influences mood but also plays a pivotal role in anxiety regulation and mental health. Learn about the HTR1A and HTR2A genes, which act like switches, controlling the serotonin levels in the brain. Understanding the SNPs in these genes can provide personal insights into your serotonin activity, offering potential strategies to alleviate anxiety, depression, and other mental health disorders. The episode further discusses how various serotonin receptors, affected by genetic differences, impact numerous physiological and psychological functions. Gain practical advice on how to balance your serotonin levels through diet, lifestyle choices, and supplements tailored to your genetic makeup, and see how this can significantly improve your mood and reduce anxiety. If you're interested in learning more about how your DNA and genetics affect your health: - Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe takes questions from SelfDecode members, answering questions like: What makes SelfDecode different from other DNA companies? How does the recommendations engine work? Can you find out if a certain supplement is right for you? Plus, he shares some of his genetic predispositions and how they correlate with his lab levels! - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we delve into the critical process of methylation, highlighting its significant impact on health issues ranging from heart disease to mental health and focusing on a lesser known methylation gene - MTHFD1. We focus on the MTHFD1 gene and choline's significance beyond methylfolate and Vitamin B12 for undermethylators. Discover how MTHFD1 impacts methylation by metabolizing tetrahydrofolate and how choline is important in supplying methyl groups. We highlight the impact of a negative MTHFD1 variant on choline usage and the potential consequences of choline deficiency, while also stressing the importance of considering other genes involved in methylation, not just MTHFR and MTHFD1. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

This episode was originally published on April 12, 2015. Dr. Jack Kruse and Joe explore unconventional approaches to health through the lens of physics and biochemistry. They cover topics like the critical roles of mitochondrial function, environmental factors such as EMFs, blue light, and dietary choices on our well-being, and challenge common health paradigms, emphasizing the importance of circadian biology, the effects of cold exposure, water quality, and the necessity of questioning mainstream nutritional advice. Next, they focus on aligning with nature's design through sunlight exposure, understanding electron flow, optimizing DHA intake, and reducing exposure to non-native EMFs. These conversations aim to encourage curiosity over conforming, urging listeners to consider the interconnectedness of their biology with their environment in the pursuit of optimal health. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we delve into the science behind the MAOB gene and monoamine neurotransmitters. Join us as we explore the crucial role of dopamine, serotonin, and norepinephrine in regulating mood and cognition. We dissect the function of the MAOB gene in metabolizing neurotransmitters and discuss the implications of genetic variations on mental health. From increased breakdown linked to mood disorders to decreased activity associated with elevated neurotransmitter levels, we unravel the complex interplay between genes and mental well-being. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe dives into the world of personalized wellness with Lauren Sambataro and Renee Belz, known as The Biohacker Babes. With roots in wellness and holistic dentistry, The Biohacker Babes bring their wealth of expertise as health entrepreneurs, nutritional consultants, and holistic lifestyle coaches to the table. In this enlightening conversation, we explore the pivotal role of lab testing in crafting personalized health regimens, emphasizing essential tests such as CBC, CMP, and functional lab tests. The Biohacker Babes also dive into the complexities of hormone regulation, genetic predispositions, and the profound impact of stress, diet, and environment on overall health, as well as discuss advanced testing methodologies including organic acids tests, the GI MAP test, and the Dutch test, designed to fine-tune health interventions for maximum effectiveness. Join us as we navigate the landscape of personalized wellness with the Biohacker Babes, unlocking the secrets to a vibrant, thriving life. - Visit https://thebiohackerbabes.com/ - Check out @biohacker_babes on Instagram - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Intro (1:10) - Important lab tests for Biohacker Babes (5:45) - Digestion (10:30) - Amino acids (15:09) - Analyzing Joes biochemistry (22:47) - Heavy metals testing (29:52) - CGM & HRV (41:57) - Epigenetic aging tests (44:42) - Continuing with digestion (51:55) - Food sensitivities (55:01) - GI Mapping

In this episode of The Joe Cohen Show, we dive deep into the world of dopamine. We'll be focusing on the role of genetics, specifically the DRD2 gene, in regulating dopamine levels and how it affects your brain's reward system, motivation, and susceptibility to addiction. Here's what you can expect to learn: How the DRD2 gene influences dopamine D2 receptors and their impact on pleasure-seeking behaviors. Understanding the variants of the DRD2 gene and its link to dopamine receptor. How genetics can affect motivation, reward processing, and potentially lead to a dopamine imbalance. The importance of maintaining balanced dopamine levels for optimal cognitive function. Join us as we explore the fascinating world of dopamine and genetics! If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Join us for an enlightening roundtable discussion featuring health experts Joe Cohen, Kris Gethin, Tim Gray, and Siim Land as they dive deep into the world of health optimization. In this episode, our expert panel explores a wide range of health tests and biomarkers, from basic to advanced, and what they mean for your health, including VO2 max assessments, heart rate variability, full-body MRI scans, gut microbiome analysis, and food sensitivity testing. We also discuss topics like EMF and heavy metal sensitivity, shedding light on how these factors can impact overall health. Get exclusive insights into the advanced wellness center AIWO and its groundbreaking solutions, and discover how AIWO's cutting-edge approach is revolutionizing health and wellness. But it's not just about theory—our panelists also share their personal experiences and tips gained throughout their own health journeys. From overcoming obstacles to achieving peak performance, they provide actionable advice to help you optimize your health and live your best life. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) Introduction (00:21) The AIWO Experience (47:31) Heart Rate Variability (53:11) VO2 max (56:22) Joe's Favorite Supplement for Recovery (58:39) Sound changes here (01:05:33) EMF & Heavy Metal Sensitivity (01:13:29) Digestive Enzymes (01:20:22) Kris' Top Health Hack

Love is in the air as we dive into the science behind relationships. In this episode, we explore the fascinating world of oxytocin, affectionately known as the "love hormone," and its connection to the OXTR gene. Responsible for encoding the oxytocin receptor, this gene plays a crucial role in shaping our social bonds, empathy levels, and even cognitive abilities. We discuss groundbreaking research, including the 'happy marriage study,' which unveils intriguing insights into how our genetic variations may influence our relationship dynamics. We uncover how oxytocin, influenced by the OXTR gene, extends beyond social bonding, playing a pivotal role in enhancing cognitive functions. Could our brain development be intricately tied to our social interactions? Join us on this journey through the science of love and genetics. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe discusses skin health, anti-aging strategies, and the science behind skincare with biohacker and beauty industry leader Amitay Eshel, CEO of Young Goose. Amitay shares his expertise on improving skin health through a combination of internal health, high-quality skincare products, and biohacking techniques. The conversation covers topics such as the efficacy of various skincare ingredients, the impact of sun exposure, and innovative approaches to anti-aging. Amitay also delves into the science of skin renewal, the role of vitamins and metabolites in skin health, and offers practical advice on creating an effective skincare regimen tailored to individual needs and skin types. - Use code “SELFDECODE” for 10% off younggoose.com - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we uncover the significance of the CLOCK and PER2 genes, pivotal players in regulating your body's circadian rhythm. Learn how these genes influence your sleep patterns, alertness levels, and even your predisposition to certain health conditions. Discover how variants in the CLOCK gene can impact your circadian rhythm, sleep duration, and daily activity patterns. Explore the associations between genetic variations in the PER2 gene and your tendency to be an early riser or a night owl, as well as its influence on sleep disorders and mood. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe brings on Dr. Ben Lynch - renowned geneticist and author of Dirty Genes - to unreavel the science of methylation, MTHFR, folates, and homocysteine. Dr. Lynch intricately unpacks the complexities of methylation pathways, shedding light on how genetic variations can impact these crucial processes. Joe and Ben then delve into the specifics of homocysteine metabolism and the role of B vitamins in maintaining optimal levels. They provide invaluable insights into personalized supplements tailored to address individual genetic predispositions and health needs. Explore the latest advancements in methylation and homocysteine management, and discover actionable strategies for promoting longevity and optimal well being. - Visit @drbenlynch on Instagram - Use code "SelfDecode10" to get 10% off seekinghealth.com If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ Timestamps: (0:00) - Intro (1:09) - State of the genetics industry (20:07) - MTHFR and methylation (1:04:59) - Is overmethylating real? (1:12:06) - Riboflavin and other B vitamins (1:18:06) - How many supplements does Ben take a day? (1:31:54) - Epigenetics and other alternative tests

In this episode of SNPit, we delve into the fascinating world of the FOXO3 gene, a genetic guardian that holds the key to a longer life. But here's the twist: did you know that certain variants of this gene could impact your lifespan more than smoking a pack of cigarettes every day for 25 years? We uncover the research behind this startling revelation and discuss the implications for our health and well-being. Plus, we reveal actionable steps you can take to optimize your FOXO3 gene for better longevity. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Joe delves deep into the world of biohacking alongside esteemed naturopath Michael Smith. Drawing on two decades of expertise, Michael shares invaluable insights into optimizing health, particularly focusing on gut health and the microbiome. From his personal journey to professional practice, Michael discusses the latest advancements in gut health research, tackling issues such as fatigue, autoimmune conditions, and more. Michael shares some practical strategies for enhancing gut health and addressing chronic conditions. Join Joe and Michael as they explore the pivotal role of lifestyle changes, targeted supplements, and personalized DNA data in achieving optimal well-being. - Learn more about Michael’s practice at https://www.planetnaturopath.com/ - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Michael Smith (01:51) - Michael's process with patients (10:34) - Important health data points (19:21) - Looking at gut health (27:35) - Food sensitivities and gut health (32:56) - Other alternative markers and tests (38:44) - Going through test results

Today, we're excited to bring you the cream of the crop – the top 6 health advice of Season 5 - that have not only resonated most with our listeners but have the power to transform your approach to health and wellness. These highlights encapsulate the essence of what it means to live well in today's world. Each clip has been handpicked for its impact, insight, and potential to inspire positive change in your life. Whether you're a long-time listener or just joining us, this episode is your gateway to the best health advice we've uncovered in Season 5. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Intro (0:16) - Oz Garcia (8:31) - Methylation (17:44) - Michael Lustgarten (24:26) - Optimal Lab Levels (29:37) - Matt Kaeberlein (46:34) - Immune System

Get an in-depth overview of the components of the immune system, learn how to identify when they're compromised, and get insights on how to support them to prepare your body for illness. Joe discusses the importance of focusing on immune support before illness occurs, diving deep into the roles of mitochondria, extracellular matrix, and inflammation, and how their strengths affects the immune system - sharing key supplements that help optimize each component! - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we focus on the FTO gene's pivotal role in fat metabolism, appetite, and weight management. Get an in-depth analysis of how the FTO gene not only influences body weight and obesity risk but also regulates appetite and fat metabolism, alongside managing emotional eating and hunger levels. We discuss the gene's connection to weight-related challenges, including its effects on insulin resistance, blood sugar levels, and energy expenditure. By understanding one’s genetic predispositions, individuals can adopt personalized approaches to diet, lifestyle, and supplementation, turning genetic insights into actionable plans for improving fat metabolism and achieving weight management goals. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

In this episode, Dr. Matt Kaeberlein, CEO of OptiSpan and co-director of the Dog Aging Project, and Joe explore the fascinating realm of rapamycin and its implications for longevity and healthspan. Dr. Kaeberlein delves into the biological mechanisms underlying rapamycin's effects, the best way to take it, and its impact on immune system processes. Gain insights from Dr. Kaeberlein's research on the mTor mechanism and rapamycin, uncovering their promising potential in extending healthspan and enhancing lifespan. Finally, Matt and Joe discuss aging clocks, biomarkers, and microbiome tests, evaluating their significance in the context of aging research and longevity enhancement. - Visit https://www.optispan.life/ - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Intro (02:24) - Rapamycin overview (22:04) - How Matt uses Rapamycin (33:24) - Biomarkers affected by rapamycin (37:33) - Microbiome and aging clocks (01:04:07) - How much can you maximize life span

Dive into the world of lab testing and unlock the secrets to optimal health. In this episode, Joe sheds light on the crucial role lab tests play in understanding our health, cautioning against the limitations of standard tests often offered by conventional medicine. Delve deep into the realm of comprehensive testing as Joe shares his insights on a variety of essential lab markers, including Complete Metabolic Panel, Complete Blood Count, Thyroid Panel, and Amino Acid Panel, among others. Learn why these tests are vital for gaining a holistic view of your well-being. Discover common misconceptions surrounding lab tests and explore the benefits of leveraging advanced tools like SelfDecode for managing and analyzing your lab results effectively. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Intro (0:40) - Mistakes people make when taking lab tests (5:06) - Important lab tests (11:34) - My journey with labs (14:55) - The lab tests I take every quarter

We unravel the intricate relationship between sunlight, Vitamin D, and your genetic makeup, as we explore the pivotal role of Vitamin D in optimizing health and well-being. At the heart of this discussion lies the VDR gene, a genetic blueprint responsible for producing the Vitamin D receptor, as we uncover it’s role alongside Vitamin D in the body. We delve into the fascinating journey of Vitamin D synthesis, from sun-kissed skin to the activation of calcitriol, the biologically active form of Vitamin D. Understanding your unique genetic profile empowers you to make informed decisions about your health, from tailored dietary adjustments to personalized supplement strategies. So, join us on this genetic exploration and unlock the secrets of optimal health. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Join Joe in a conversation with successful biohacker and CEO of Neurohacker Collective, James Schmachtenberger. James shares his two-decade-long journey with biohacking, focusing on improved energy, cognitive function and how NAD changed his life. Learn about utilizing research, software solutions like genetics and lab tests, lifestyle changes, and supplementation for optimizing your health. - Use code “SELFDECODE” to get 15% OFF any product at neurohacker.com - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Intro (1:28) - Jame’s first supplements and approach (8:24) - Energy and mental clarity (13:11) - Putting health into your own hands (19:55) - Studies on Lyme Disease (22:47) - Trusting your intuition vs a data driven approach (30:17) - Exercise (37:22) - Taking too many supplements (45:29) - The one lab marker always affected by infection (52:48) - Collagen and joint (59:02) - NAD (1:09:30) - Different Qualia Products (1:11:25) - Unique biohacks

Ever wondered why some people seem to avoid sickness effortlessly, while others catch every bug in the vicinity? It turns out, luck and genetics may both play a role. In this episode, we uncover the secrets of the IL6 gene, responsible for coding interleukin 6 (IL-6), a crucial immune messenger. Discover how certain variants of the IL6 gene, such as rs1800795, are linked to higher or lower IL-6 levels, affecting immunity and susceptibility to infections. But the story doesn't end there – we explore other variants like rs1800796, connecting genetic makeup to conditions like acne, longevity, muscle recovery, and inflammatory diseases. Is your IL6 gene making you ill, or is it your genetic strength? If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Unlock the secrets to longevity with our deep dive into biohacking, lab tests, and supplements! In this episode, we explore the crucial role of lab markers in longevity, optimal lab test ranges, and associations that impact aging. Dive into the world of supplements, addressing concerns about tolerance and when is the right time to supplement for lifespan. Joe and Michael discuss the Dunedin Pace Test and its significance in aging, while shedding light on the impact of lifestyle changes and immune system health. Going deeper into the science, Michael and Joe analyze mortality risk, liver damage, protein intake, urea lives, fiber intake, calorie restriction and so much more on biological aging.Join us on this journey of discovery, as we discuss data points, close with valuable insights, and chart our future plans for further exploration into the fascinating world of longevity. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ - Visit Conquer Aging or Die Trying! Timestamps: (0:00) - Introduction (2:54) - How many supplements does Michael take? (11:44) - Red blood cells (14:47) - Can you increase longevity with no supplements? (29:36) - Dunedin Pace (37:28) - Longevity based lab markers (40:06) - The immune system (42:36) - Labs affected by too much supplementing (57:00) - Testosterone and LDL (1:01:39) - New study on aging (1:08:09) - Protein and amino acids (1:13:30) - Urea and protein (1:18:30) - Body fat and BMI (1:23:57) - Supplementing vs training (1:30:23) - Michael’s current diet (1:33:34) - Michael’s current work (1:47:17) - Urea and Uric Acid (1:53:31) - Caloric restriction and longevity

This episode explores the transformative potential of the UGT1A1 gene in your body’s ability to detox toxins. Uncover the role of this gene in Glucuronidation, a crucial chemical reaction that enhances the body's ability to detoxify. Learn about the impact of genetic variations which can reduce the activity of the UGT enzyme, hindering the body's detox capabilities. Discover practical solutions to counteract toxic buildup and support the body's natural detoxification processes. This episode unveils the science behind genetic detoxification, providing valuable insights into personalized approaches for optimal health. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

In this episode, Joe discusses the fascinating topic of methylation and its importance for overall health. From explaining the tests that can determine if you're an over or under methylator, to providing recommendations on how to support your methylation process, Joe covers everything you need to know. Discover how genetic variations, such as MTHFR and MTRR, can impact your need for nutrients like folate and B12. Get insights into specific lab markers and supplements that can help optimize your methylation levels. Find out how sleep, exercise, stress management, and detoxification play a crucial role in methylation. Join Joe as he shares his expert knowledge on methylation and provides practical strategies to improve your wellbeing. If you're interested in learning about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Join us on an exhilarating journey into the intricate world of choline and the PEMT gene. Delve into the significance of choline and how it impacts cellular health, brain function, and beyond, and how PEMT plays a role in choline production. Discover the intricate genetic variants within PEMT, unravelling how certain alleles influence susceptibility to choline deficiency and associated risks. Plus, learn how estrogen stimulation plays a crucial role, posing unique challenges for different demographics. Tune in to 'SNPits' on The Joe Cohen Show to grasp the genetic intricacies impacting our health and explore how personalized nutrition can be your shield against genetic vulnerabilities. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

In this episode, we delve deep into the importance of the immune system and how you can optimize it for peak performance. Immunity isn't just about avoiding the common cold; it can impact all areas of health, from physical wellness to mental clarity. Joe, a seasoned biohacker, shares his personal experiences and strategies for ramping up immunity, shedding light on how a data-driven approach can yield significant benefits. We also explore a comprehensive protocol for when you do get sick, outlining a series of steps incorporating diet changes, specific supplements, and unique lifestyle adjustments. From baths to peptides, discover an array of techniques to fortify your body's defenses and recover faster from illness. Join us for this enlightening conversation that will leave you better prepared to face health challenges head-on. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Intro (1:02) - What Oz Tests For (5:08) - Pros and cons of testing (11:15) - Muscle & Tendon Recovery (22:13) - How to decrease homocysteine (29:57) - Immunity

In this episode, Joe dives deep into the fascinating world of MTHFR and what you can do if you carry the negative variants! Join us as we unravel the mysteries surrounding these important topic and explore everything you need to know about genetic variations, folate metabolism, and the crucial role of methylation in our bodies. Joe breaks down the science behind MTHFR, explains how to interpret your genetic results, and shares valuable insights on optimizing your folate levels. Discover the benefits of methylfolate, explore the connection between homocysteine and methylation, and learn practical tips for supporting your overall health. If you're curious about the inner workings of the MTHFR gene and how it influences your well-being, this episode is for you! If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

You’ve probably heard of the hype around MTHFR and how it affects methylation, but what about other genes implicated in the methylation process? In this SNPit the spotlight shifts to MTR and MTRR, and how they can affect levels of homocysteine in the body. Learn all about why homocysteine is important, how genetic variants can affect your levels, and other factors that affect methylation. … Because MTHFR doesn’t tell the whole story. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

In this episode of the Joe Cohen Show, we welcome Dr. Darshan Shah, a renowned health specialist, surgeon, author, and founder of Next Health. We dive deep into the cutting-edge health optimization methods used at his clinic to extend lifespan and health span. Dr. Shah shares intriguing insights on the role of biohacking, the importance of managing metabolic disease, micronutrient testing, and the function of certain nutrients in our bodies. Throughout the discussion, Joe demonstrates how he uses SelfDecode to analyze his personal health data, illuminating the power of personalized health management. - Follow @darshanshahmd on Instagram - Visit Next Health: https://www.next-health.com/ - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Introduction (01:16) - The journey of extending lifespan with Dr. Shah (04:15) - Most common lab markers that are high (07:19) - Optimizing for insulin and cardiovascular health (20:59) - Tests for cancer (22:26) - Becoming the CEO of your health (28:07) - Micronutrient testing (33:43) - Amino acid tests

Dive deep into the fascinating world of brain health, brain mapping, and the game-changing impact of neurofeedback on anxiety, sleep, executive function, and so much more. In this episode, Dr. Andrew Hill - a neuroscientist with a Ph.D. in Cognitive Neuroscience from UCLA and is best known as an expert neurofeedback practitioner and brain fitness coach - shares his decades of knowledge to help us understand the power of neurofeedback. Discover the pivotal role of brain mapping in tailoring personalized neurofeedback treatments, how certain brainwaves in different areas of the brain affect your cognition, and what you can do to optimize sleeping patterns, reduce anxiety, and even IMPROVE your social skills! Discover the nuanced impact of brainwaves like theta and beta waves on cognition. Explore how focusing on these waves can optimize specific areas of your health, from enhancing executive function to reducing anxiety and improving sleep patterns. Join us for an eye-opening journey into brain health and neurofeedback. - Use code “SELFDECODE” to get 50% off unlimited brain mapping at https://peakbraininstitute.com/ - Follow @peakbrainla on Instagram - Check out SelfDecode - Join Joe’s online community

Dive into the world of immunity optimization with Joe and Siim Land - all the way from India! From supplement stacks to proactive measures for bolstering the immune system, Siim and Joe dissect their distinct immune-boosting protocols aimed at fortifying immunity and enhancing the body's defense mechanisms. Joe and Siim share their tailored approaches to prevent illness and expedite recovery when under the weather. Gain exclusive insights into their supplement regimens, tailored to optimize immune response and foster resilience against sickness. Highlighting key lab markers crucial for optimizing health, Joe and Siim also shed light on the pivotal metrics they prioritize, uncovering the essential lab markers important for monitoring and fine-tuning immune function. - Check out SelfDecode - Join Joe’s online community - Follow Siim Land on Instagram

Unlock the mysteries behind methylation, MTHFR, and homocysteine! Join us as we dive into these widely recognized yet often misunderstood terms that impact heart health, mental well-being, fertility, and more. The surge in popularity around methylation, MTHFR, and homocysteine has led to a barrage of misinformation. In this enlightening episode, we've invited Dr. Denise Furness, a distinguished molecular geneticist boasting over two decades of expertise in folate nutrigenomics, methylation, and DNA damage. Join us for a wealth of game-changing insights as Denise delves deep into: Understanding methylation's pivotal role in your health Unraveling the impact of the MTHFR gene on methylation levels Optimal homocysteine levels and their significance Essential lab markers for optimizing your health Debunking concerns about over-methylation If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

I’m thrilled to be back with a brand-new season of The Joe Cohen Show! We’re kicking off the season with truly life-changing knowledge with a popular returning guest, Dr. Oz Garcia! In this episode, Dr. Oz Garcia and I explore the keys to happiness, the transformative power of meditation, and the world of biohacking for pain reduction and sleep optimization! We dive into the intricacies of mood, discussing all the different pathways that affect your overall mood and the different approaches to consider depending on your unique biology. Are you dependent on serotonin for improved mood? Is your GABA pathway the culprit for your bad days? What about the vagus nerve? Dr. Oz highlights how treatments are completely different based on your body's needs! As the conversation unfolds, you'll find yourself immersed in discussions about mood and pain, as Dr. Oz shares some of his secret supplements and lifestyle hacks that reduce his pain and allow him to continue doing all the physical activities that he loves.

In this special episode, we've curated the most influential moments and expert insights from some of our remarkable guests of Season 4. Get ready to uncover a treasure trove of tips and tricks to supercharge your health and well-being. From optimizing gut health to longevity secrets, this episode is your ultimate guide to living your best, healthiest life. Tune in now for a power-packed journey into the world of wellness and discovery. Don't miss out on this collection of wisdom from the best in the field!

Have you ever wondered if a single gene could hold the key to unlocking your cognitive potential, or perhaps, be the culprit behind those moments of brain fog? Discover the fascinating world of the BDNF gene in this episode of SNPits. Explore how your genetic makeup can impact your cognitive function and memory and uncover the association between BDNF variants and brain health. Plus, learn how to naturally boost your BDNF levels for improved learning and mental performance. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Do you find it hard to drift off to sleep at night? Wondering why some nights are filled with vivid dreams while others leave you feeling like you've barely closed your eyes? What's the true impact of those late-night screens and the foods we consume on our sleep cycle? In this episode, Joe and Dr. Greg answers questions unraveling the mysteries of sleep and revealing the intricacies of our body's internal clock. Together, they explore the pivotal role of sleep in our overall health, spotlighting specific genes that might influence your sleep patterns and how you can modify your habits for a restful night. Shifting their attention to nutrients and dietary habits, they identify certain foods and minerals that promote sleep, like tryptophan and melatonin. From understanding genes like PER and CLOCK that regulate our circadian rhythms, to the essential role of diet, this episode is a comprehensive exploration of the science behind sleep! - Check out SelfDecode - Join Joe’s online community Timestamps: (0:00) - Intro (7:10) - Why do sleep disorders increase with age? (7:45) - How can I easily fall asleep? (14:56) - sleeping a lot but still tired (18:09) - Waking up in the middle of the night (26:54) - Waking up panicked (30:32) - Is there a way to increase slow wave sleep? (33:21) - Can SAD bring on insomnia? (34:43) - melatonin genes and sleep (36:28) - inconsistencies in sleep? (37:17) - how do I make sleep more restorative (38:35) - Is napping okay? (40:32) - How to increase REM sleep time?

In this episode of the Joe Cohen Show, we dive deep with renowned nutritionist Dr. Oz Garcia. With a lifetime of experience in the realm of nutrition, Oz shares his transformational journey from being a "rockstar nutritionist" to confronting the challenges of his own health issues. We explore the importance of not just focusing on what we eat, but also delving into data-driven wellness practices that can pave the path to optimal health. Learn about the markers and biomarkers that matter, how to achieve resilience in the face of illness, and why a data-driven approach is the key to unlocking true health. Whether you're a health enthusiast or a professional in the field, this conversation with Oz Garcia is an essential guide to elevating your nutrition strategy and achieving optimal health. - visit ozgarcia.com - Follow Oz @ozwellness - Check out SelfDecode - Join Joe’s online community Timestamps: (0:00) - Intro (1:52) - Oz's process in helping a client get healthy (18:56) - Changing the way we look at health (34:59) - Supplements and reading lab levels (53:27) - Meditation and spiritual practices

The pursuit of optimal health is a lifelong journey, so finding the motivation to continue to make the right decisions can sometimes be difficult. If you’re not working on a tangible goal - like running a marathon or reaching a PR in squats - then how can you keep yourself from falling into unhealthy habits? In this episode, Andrew Steele - former Olympian and co-founder of DNAfit and Aila - and Joe share tips on how to set realistic goals that keep you striving for optimal health and performance. Andrew discusses the importance of health trackers in understanding your next steps, and shares how you can start becoming more aware of your diet and supplement changes to fuel you on your road to optimal health. Both Joe and Andrew share their lifechanging journey with genetics, and how they’re now incorporating labs to get a holistic picture of their health. - Visit https://meetaila.com/ - Check out SelfDecode - Join Joe’s online community

Chronologically, you get 1 year older every year. But how old are you getting biologically? In order to optimize longevity, you need to understand biological aging. With all the different longevity and biological aging tests, it can be difficult to understand where to start. Fortunately, we got Ryan Smith from Tru Diagnostic on todays episode to guide you on all things longevity and biological aging. In this episode, Ryan highlights the different biological aging tests and which one is the most accurate. He also gives helpful tips on how to reduce your pace of aging, and how that’s important for your overall lifespan. Ryan Smith is founder of TruDiagnostic, which has created the largest private epigenetic database in the world with over 25,000 patients tested. From this dataset, they have created many new algorithms to interpret methylation data including algorithms to predict inflammatory markers, disease diagnosis, telomere length, aging pace, immune cell subsets, cellular replication, and more. - Visit trudiagnostic.com - Check out SelfDecode - Join Joe’s online community Timestamps: (0:00) - Intro (1:48) - Where does epigenetics fall into aging biomarkers? (21:52) - Different responses in anti-aging protocols (39:44) - epigenetic test vs lab tests (48:42) - How to use biological age tests to improve health (55:09) - pace of aging (1:05:15) - Immune system age (1:09:11) - How to reduce the pace of aging (1:26:39) - How many supplements does Ryan take per day? (1:35:42) - Metformin and rapamycin on aging

Is the ApoE gene solely a predictor of cognitive decline, or is it just one piece of a larger, more intricate puzzle? In today's episode, we focus on the ApoE gene, a genetic player that’s most notoriously linked to Alzheimer's Disease. Julia dives deep into the three major variants called E2, E3, and E4, discussing how they change the shape of the ApoE protein and impact how well it functions. she also opens up the curtain on other health issues that can be caused by the ApoE gene —impacting your cardiovascular health, your body's inflammatory responses, and even your longevity. Join us as we explore the layers of ApoE, debunk misconceptions, and discuss how understanding this gene could be a key step in taking control of your cognitive and overall health. Whether you're a genetic novice or a seasoned veteran in the world of SNPs, this episode will provide a comprehensive, yet easy-to-understand look into the multi-faceted role of the ApoE gene. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Why are there so many different versions of the same supplement? Is it all just a marketing ploy, or do they all have different effects on your health? In this episode, Emiel Bakker from Nootropics Depot comes on to dive into the complex world of dietary supplements, where not all products are created equal. He gives us an inside look at the science behind developing a supplement, from deciding on an extraction method to choosing between a fruiting body vs. mycelium. We uncover the nuanced factors that influence the efficacy and effects of some popular supplements, including: Lions Mane: How can different extraction methods affect its cognitive benefits? Bacopa: How to navigate its varieties for optimal memory enhancement. Saffron: Its antidepressant effects and the factors that contribute to its potency. Ubiquinol vs CoQ10: The dynamic duo of cellular energy—what's the difference and why does it matter? And more! Emiel Bakker is the product specialist at Nootropics Depot and Natrium Health, a company specializing in creating the best nootropic powders and capsules online. They offer pure nootropics and dietary supplements at the best prices. - Visit Nootropics Depot website - Find Emiel @prettychill_nd - Check out SelfDecode - Join Joe’s online community Timestamps: (0:00) - Intro (2:07) - Different variations of the same supplement (17:21) - Erinacine A and Lion’s Mane (19:57) - Pregnenalone (26:51) - Tetrahydromagnolol and Magnolia Bark (40:36) - How SelfDecode helps you understand supplements (42:29) - Bacopa for Serotonin (57:58) - Different effects of Maca (1:09:28) - Oroxylin A and effects on cognition (1:13:53) - Effects of Saffron (1:20:28) - How many supplements do you take a day? (1:22:33) - Ubiquinol vs CoQ10 (1:24:29) - Licorice Extract

How can you measure autophagy for certain? And what are the key stages to an effective fasting regimen? Returning guest, Dr. Joseph Antoun from L-Nutra, the visionary company spearheading the fast-mimicking diet revolution, is here to answer these questions. In this enlightening conversation, we delve into: New clinical trials that prove the fast-mimicking diet not only mimics fasting but enhances the benefits. The science of autophagy: What it is, its tremendous health benefits, and groundbreaking methods for measuring it—no more guesswork! The three stages of fasting, and how you can reach each one for optimal health benefits Dr. Antoun's recommended frequency for a 5-day fasting regime per year—because timing is everything. How to nail intermittent fasting and incorporate it seamlessly into your life. A deep dive into clinical trials that show the fasting mimicking diet can actually reverse diabetes. And so much more! Dr. Joseph Antoun is the CEO & Chairman of the Board of L-Nutra and a Member of the Forbes Business Development Council. He is also the former CEO of Health Systems Reform, an organization committed to optimizing public health. - Get 20% OFF All Products at https://l-nutra.com/ by using Code “JOE20” - Check out SelfDecode - Join Joe’s online community Timestamps: (0:00) - Intro (2:58) - Fasting mimicking diet best benefits (5:12) - Discussing autophagy (23:58) - Recommended number of times to fast (26:10) - Fasting for diabetes (28:27) - How to properly do intermittent fasting (42:00) - Nutrient sensing (47:43) - Theories on stem cells (50:02) - Clinical trials supporting fasting mimicking (54:57) - Biological aging tests (1:07:56) - Does Joseph take supplements?

Welcome back to SNPits, a short form series helping you decode your DNA, one gene at a time. In this episode, we delve into the fascinating world of the COMT gene, commonly dubbed the "Warrior/Worrier" gene. We unpack the science behind this gene's influence on stress regulation, emotional resilience, and even cognitive function. Is the "Warrior/Worrier" label an oversimplification, or does it offer a genuine glimpse into our genetic predisposition? Whether you're well-versed in genetics or just taking your first steps into this fascinating realm, today's episode promises to be an intriguing exploration of the role genes play in shaping our reactions to life's challenges. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ Links: The warrior variant and its effects on stress and working memory [R, R, R, R] The worrier variant and its effects on stress and emotional resilience [R, R, R, R, R].

Join us as we dive deep into the world of genomics, nutrition, and precision health with Dr. Greg Nacarelli, a leading expert in naturopathic medicine and genetics. Dr. Nacarelli delves into the intricate interplay of genetics, environment, and lifestyle on our health, explaining why personalizing health care is the future. Greg touches on the value of understanding individual genetic profiles and how this can be utilized for personalized nutrition and health coaching. With extensive academic qualifications and years of experience working with SelfDecode, Greg brings a unique blend of expertise to the table. Whether you're a health professional or just a health enthusiast, this episode offers invaluable insights into the cutting-edge world of genomics and how it's shaping the future of personalized medicine. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ Timestamps: (0:00) - Intro (2:53) - Practitioners Course (8:09) - How A Health Practitioner Uses SelfDecode (16:55) - Using the recommendations feature (25:44) - Continuing the health practitioners use of SelfDecode

Dive deep into the intricate world of gut health with the pioneer himself, Dr. Steven Gundry. Once dismissed as pseudoscience, the concept of 'leaky gut' has become a cornerstone of modern health understanding, and no one knows this better than Dr. Gundry. In this enlightening episode, we unravel the real science behind leaky gut, the dangers of food sensitivities, and the profound effects of glyphosate on our system. Beyond just understanding, Dr. Gundry shares actionable insights on optimizing your gut health to transform your overall well-being. Whether you're a long-time health enthusiast or just beginning your journey, this episode offers a treasure trove of knowledge. Timestamps: (0:00) - Introduction (3:30) - Dr. Gundry's current ideal diet (9:12) - Autoimmune Disease Reversal & Leaky Gut (17:08) - IgG Antibodies (27:29) - Other markers attributed to leaky gut (34:14) - Glyphosate and linoleic acid (48:20) - Top things to counteract food sensitivities (54:23) - LPa, ApoB and LDL Cholesterol (1:02:09) - Thoughts on diet studies with beans and whole grains (1:05:44) - Protein Restriction & Intermittent Fasting (1:11:08) - Fibers and gas

Welcome to SNPits, a new, short-form podcast series that takes you on a deep dive into specific genes, unraveling the science behind them and their impact on health. In this episode, we tackle the MTHFR gene and its rise to fame. We explore how 'typos' in our genes, known as SNPs, influence our health, and dive into the debate surrounding one of the most studied genes in the world. Is the MTHFR gene truly a culprit in conditions like heart disease and chronic fatigue, or is it a scapegoat? Join us as we decode the science, bust some myths, and take a closer look at how our genes really affect our health. Whether you're a genetics guru or new to the subject, this episode offers an insightful and entertaining look at the complexity of our genetic code. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ Links: Some studies found a 35-70% reduction in enzyme activity [R], and links between MTHFR variants, higher homocysteine, and: Heart disease and stroke [R, R] Fertility and pregnancy issues [R, R, R, R, R, R] Mental health issues [R] Migraines with aura [R, R] Some studies found no evidence for these links. Some even found the opposite results. In one study, MTHFR variants were linked to a lower risk of death from heart disease [R, R, R, R, R]

To celebrate the richness of this season, we've compiled the most powerful insights and the unforgettable moments into a special "Best of Season 3" episode. From experts breaking down complex health subjects to invaluable pieces of advice on achieving your healthiest self, this episode is your ultimate guide to the knowledge treasure of Season 3.

Is anxiety truly genetic? How do our genes and environment shape our response to stress? Are we all experiencing the world differently based on our unique biochemical make-up? In this episode, Joe and Dr. Greg (SelfDecode Health Expert) dive deep into the realm of anxiety, answering questions from the SelfDecode community and unmasking the role our brain's biochemistry plays in the expression of anxiety. Joe and Greg discuss the role of mental health in overall wellness and highlight specific genes that you can look at to potentially help you get rid of anxiety. They then focus on the nutrients most commonly depleted under chronic stress and their links to anxiety, and break down some herbal supplements that work wonders in balancing our brain's neurotransmitters. From the influence of specific genes like COMT and MTHFR, to the vital role of minerals like magnesium, zinc, and vitamin B6, this episode is a deep dive into the science of anxiety! If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠