The Future of Everything

When Stanford bioengineer Markus Covert first decided to create a computer model able to simulate the behavior of a single cell, he was held back by more than an incomplete understanding of how a cell functions, but also by a lack of computer power. His early models would take more than 10 hours to churn through a single simulation and that was when using a supercomputer capable of billions of calculations per second.Nevertheless, in his quest toward what had been deemed "a grand challenge of the 21st century," Covert pressed on and eventually published a paper announcing his success in building a model of just one microbe: E. coli, a popular subject in biological research. The model would allow researchers to run experiments not on living bacteria in a lab, but on a simulated cell on a computer.After all was said and done, however, the greatest takeaway for Covert was that a cell is a very, very complex thing. There were fits and starts and at least one transcendent conceptual leap — which Covert has dubbed “deep curation” — needed to make it all happen, but he found a way. As Covert points out, no model is perfect, but some are useful. And that is how usefulness, not perfection, became the goal of his work, as he tells fellow bioengineer Russ Altman in this episode of Stanford Engineering’s The Future of Everything podcast. Listen here, and subscribe to the podcast here. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

COVID-19 is changing how many scientists, like Stanford sleep expert Rafael Pelayo, MD, view their field. First off, the shift to telemedicine is providing Pelayo, author of the new book How to Sleep, an unprecedented glimpse into the sleep environments of his patients. “I’m making house calls for the first time,” he says.Second, surprisingly, some of his patients, unburdened of long commutes, say they are sleeping and dreaming more than ever. But, others are not so fortunate, reporting increased trouble sleeping and more nightmares. Pandemic-induced or not, the consequences of lost sleep are universal and readily apparent in the country’s diminished productivity, in the rates of stroke, heart attacks and car accidents, and in the pervasive irritable mood many can’t seem to escape.To get a better night’s sleep, Pelayo says, put the screens away, consider that continuous positive airway pressure (CPAP) machine if you snore (it could save your life, he says), and find a way to create a personal sleep environment even if you share a bed with someone you love.Join us as Rafael Pelayo and our host, Stanford bioengineer, Russ Altman, talk sleep on this episode of Stanford Engineering’s The Future of Everything podcast. Listen here, and subscribe to the podcast here. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Marietje Schaake was a Member of the European Parliament from 2009 to 2019 and now serves as the international policy director at Stanford University’s Cyber Policy Center and international policy fellow at Stanford’s Institute for Human-Centered Artificial Intelligence. As she has watched democracy evolve in the age of instantaneous global communication and hyperconnected social media, she has grown concerned about the resilience of democracy as technology disrupts the status quo. While the technologies—and the often-unregulated companies who created them—claim to be well-meaning, she says democracy is under attack from propagandists and bad actors using these transformative tools in troubling ways. The business models based on surveillance and advertising were never designed with preserving democracy in mind. We now find ourselves at a decisive moment for the future of elective government, she says. America and other democratic nations can expose the meddlers and their techniques or succumb to their approaches. The solutions, she says, begin at the grassroots and with the tech companies. We need real-time and independent monitoring and research to better expose manipulations and to allow for evidence-based policy making. Join Stanford Engineering’s The Future of Everything podcast for an insider’s sobering look at democracy in the digital age. Listen here, and subscribe here to the podcast. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Andrew Huberman is a Stanford neurobiologist and ophthalmologist keenly interested in the biology of stress and ways to manage stress.He’s developed and tested a number of stress-relieving techniques — from specific patterns of breathing to visual tools — and uses virtual reality to help humans control their stress in adaptive ways. He is also testing how people can access better sleep using stress-relief tools. Much of this work is done in collaboration with David Spiegel, MD, associate chair of psychiatry and behavioral sciences at Stanford Medicine.Huberman studies how the nervous system takes in and processes information and uses it to drive reflexive and deliberate behavior. In that regard, humans are largely visual animals. The vast majority of the information we collect about the world comes through the eyes, and those circuits are tied directly to our most primordial “fight or flight” systems. Light, and how our brains process light energy, is closely tied to our stress mechanisms. Our most immediate reaction to stress, he notes, is for our pupils to dilate, which changes how we see the world — literally — in a way that allows us to better respond to threats. Breathing and vision can also be used to control stress.Huberman tells us all about it in this episode of Stanford Engineering’s The Future of Everything podcast, hosted by Stanford bioengineer Russ Altman. Listen and subscribe to the podcast here. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Manu Prakash was in France when COVID-19 took hold throughout the world. There, the Stanford bioengineer, famous for “frugal science” like his $1 field microscope made of paper, witnessed the challenges a relatively well-resourced nation experienced holding back the disease. His head was soon filled with visions of the nightmare awaiting developing nations, given that a COVID-19 test in developing countries can cost as much as $400.In a flurry, Prakash jotted down an engineering manifesto of sorts for a worldwide revolution in open-source, inexpensive healthcare solutions. As he saw it, here were three areas of greatest need — diagnostics, protective equipment and critical care.From his lab at Stanford, Prakash, his students and partners in academia, industry and government around the world led a frenzy of invention that yielded an array of transformative products in just months. There was the electricity-free COVID-19 test based on a simple children’s flashlight. There was Pneumask, a full-face, reusable N95 protective equipment for caregivers inspired by the mask Prakash uses in one of his favorite pastimes, snorkeling. And then there was the “N95 factory in a box” Prakash and his lab developed using cotton candy machines to spin N95-quality filtration materials from waste plastics. Finally, to tackle one of the most technical challenges of all, he built a global consortium with manufacturing partners in India, Kenya and Nepal to design an open-source full-feature ICU ventilator, known as Pufferfish (Prakash has a penchant for naming products after marine life) — bringing a low-cost critical care solution to the world. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

With the emergence of touchscreen smartphones, tablets and watches, so much of our lives is spent on our devices that in many ways we are what appears on screen. This “mediatization,” as Byron Reeves, a professor of communication at Stanford University, puts it, sparked a remarkable and unprecedented study of the way we live today.In a series of field studies, Reeves has recorded screen time of his subjects one frame every five seconds for days on end — with promises of absolute privacy, of course. He then uses artificial intelligence to decipher it all — words and images are recorded and analyzed. The portraits that emerge play out like cinema, revealing never-before-imagined insights into how people live in the screen-time world. Reeves says the pervading sense that everyone is multitasking and that attention spans are narrowing is not just a hunch, but demonstrable in the data. Our screens are often filled with radically different content side-by-side and each bit gets consumed in rapid-fire bursts of focus, often no more than 10 to 20 seconds each. Join us for a fascinating look at our screen-time culture on the latest episode of Stanford Engineering’s The Future of Everything podcast. Listen here. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

There was a time when all great cities were built near water. Whether for agriculture, aesthetics, energy or just plain drinking, water was a life-affirming, life-sustaining resource. But with the advent of advanced engineering in the form of dams, pumps and pipes, cities like Los Angeles thrived in places with very little fresh water. Now, global climate change is leaving many of those cities in danger of running dry.But there is hope on the horizon, says Newsha Ajami, senior research engineer at the Woods Institute for the Environment and director of urban water policy with Stanford University’s Water in the West program. Just as engineering made it possible to store and pump fresh water great distances, the field is developing new ways to use less water, to store more of this prized resource, to repurpose used “gray water” for non-potable uses like agriculture, and to inform inventive policy approaches to conserve fresh water.It won’t be easy, she says. California alone has over 7,000 independent water agencies that must be wrangled into a cohesive team to make it real, but recent progress has people believing once again that our parched cities can be saved. It’s all here on this episode of Stanford Engineering’s The Future of Everything podcast. Listen here. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In recent years, biologists have learned that the vaginal microbiome — the make-up of the bacteria in the vagina — during pregnancy may be the best predictor of pre-term birth. It is a valuable finding that could reshape obstetrics. What is perhaps more revelatory about this emerging knowledge is that biologists have learned it from a surprising source: statistics.Stanford’s Susan Holmes is one such statistician in the rapidly evolving science of using statistics to understand biology. Holmes is now turning her attention to improving our understanding of the remarkable human immune system to help fight cancer and other deadly diseases. She says that the statistician’s greatest contribution to biology may not necessarily reside in analyzing the myriad numbers and data points available these days, but rather in divining and explaining which patterns are replicable and which are not.Join bioengineering Professor Russ Altman for the latest episode of Stanford Engineering’s The Future of Everything podcast to discuss the fascinating and fast-evolving field of statistical biology with a leading proponent of the science, Susan Holmes. Listen here. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Mechanical engineer Sheri Sheppard got her start in engineering working on the Corvette for General Motors and later worked for both Ford and Chrysler.Back then, she was among a handful of women engineers in the auto industry, where she learned firsthand the risks a monolithic culture presents.Today, Sheppard is a professor at Stanford University, where she works to encourage diversity in the student body, in the classroom and in the curriculum. She says that engineering needs to reach beyond the traditional disciplines to tap into sociology, history, ethics, psychology and even philosophy to help engineers explore the “peopleness” in the challenges they are trying to solve.In that pursuit, she encourages women and minorities eager to transform their field to become what her colleague Deb Meyerson has dubbed “tempered radicals” — leaders who can rock the boat while remaining in the boat. The result, Sheppard tells Stanford Engineering’s The Future of Everything podcast, is more empathetic engineering that benefits everyone in society. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We’re all familiar with those algorithms on our favorite e-commerce and streaming services that recommend purchases, books or movies based on what “others like you” have enjoyed. In the industry, they are known as “recommender engines.”Medical doctor Jonathan Chen is an assistant professor of medicine at Stanford and an expert in bioinformatics who wondered if the medical profession might benefit from similar artificial intelligence. He now creates recommender engines for doctors that comb real-world clinical data to help them make key decisions based on steps other doctors have taken with similar patients, empowering individuals with the collective experience of the many.Chen tells Stanford Engineering’s The Future of Everything podcast that such programs will soon be commonplace in exam rooms, helping doctors become better at what they already do and making medical practice a more consistent, universal experience for everyone. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Artificial intelligence can help us design safety-critical systems for aircraft and other vehicles that are more robust to the many sources of uncertainty in the real world, says aerospace professor Mykel Kochenderfer.Building systems that meet the exceptionally high level of safety expected of commercial air transport is challenging, but Kochenderfer says that the key is in modeling the likelihood of the full spectrum of outcomes and planning accordingly. Validating the safety of these systems is also difficult, often requiring billions of simulations. He tells Stanford Engineering’s The Future of Everything how AI, empowered by algorithms such as “dynamic programming,” can make autonomous systems safer. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

With a degree in photography with a concentration in mathematics and boasting high-profile jobs at two of the most influential visual outlets in the last century, National Geographic and Instagram, Pamela Chen knows a bit about the state of modern photography and the algorithms that shape popular tastes.Now, as the Human-Centered Artificial Intelligence and John S. Knight Journalism (HAI-JSK) Fellow at Stanford, she studies how artificial intelligence is shaping the role of photography in society: particularly the rise of memes, which she refers to as “packets of culture.” Chen says mathematics is redefining photography as much as artistic vision, altering both consumer tastes and the creative eye of photographers who want to become – or remain – relevant in a rapidly changing world.Chen joins The Future of Everything host Russ Altman to discuss why artificial intelligence’s influence on photography is only just in its infancy and why lovers of photography still have power to shape AI as much as it shapes us. [Listen here.] Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Stanford engineering alumnus Michael O’Sullivan, now at the University of Auckland, likes to say his business is the “science of decision-making,” and that expertise paid off handsomely in his native New Zealand’s successful response to COVID-19.O’Sullivan pivoted his knowledge of computer modeling, usually reserved for optimizing business processes, to help predict how quickly the disease might have spread through the island nation’s 5 million inhabitants, and to gauge various national response strategies. Based on expert models from a team of researchers that included O’Sullivan, New Zealand’s leadership took an aggressive approach and quelled the disease after just a month of lockdown.O’Sullivan tells Stanford Engineering's The Future of Everything he is now turning his attention to highly detailed geographic models to better understand how COVID-19 could spread geographically if a future outbreak occurs. He is also putting his modeling to work to help analyze how response to the disease will impact the coming flu season and how the lockdown might have had negative effects on the treatment of other illnesses such as the early detection of cancer. Michael O’Sullivan, MS ’97, PhD '01, would like to acknowledge the work of Kevin Ross, MS '01, PhD '04 (Precision Driven Health), and Pieta Brown (Orion Health), who have been instrumental in making a pipeline for the modeling work discussed in this podcast readily available to the New Zealand government. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Megan Palmer, executive director of Biopolicy and Leadership Initiatives at Stanford, joins bioengineer Russ Altman for this episode of Stanford Engineering’s The Future of Everything podcast, to discuss how we can better prepare for future virus outbreaks and how the world could ultimately become a more secure, peaceful and prosperous place as a result of the lessons learned from COVID-19. The key to that future, she says, will be better coordination and communication among world leaders in science, security and policy, who will be charged with foreseeing and preventing the next crisis. Likewise, it will take better cooperation between humankind and the natural world. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

As she tells it, the life of immunologist Catherine Blish has not changed all that much from what it was just a couple months ago.Her lab still studies deadly infectious diseases, but instead of myriad killers like HIV, dengue fever, influenza and the like, her team is now focused solely on the SARS-CoV-2 virus that causes COVID-19. Only a select group of researchers in the world are qualified to work with such serious viruses, and fewer still are properly equipped with the protective gear and sophisticated ventilation systems needed to guarantee the safety in the lab.Blish recently joined Russ Altman for this special COVID-19 edition of Stanford Engineering’s The Future of Everything podcast, to talk about the unique character of the virus, a few surprises she and others have unearthed in their research, and how once-competitive scientists around the world have united to find treatments and a vaccine that are critical to ending the pandemic for good. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Seema Yasmin is a rarity in public health: a medical doctor who is also a journalist. As such, she’s seen a lot, from Ebola in West Africa to SARS and MERS, and now COVID-19, the most serious pandemic in a century.Yasmin is currently director of research and education at the Stanford Center for Health Communication. From her years in the Epidemic Intelligence Service at the U.S. Centers for Disease Control and Prevention — a group widely described as “the disease detectives” — and as a reporter for The Dallas Morning News, Yasmin says that the greatest impediment to halting an outbreak is the rapid spread of bad information, and even abject disinformation, which when abetted by social media can spread faster than the disease itself. To halt the pandemic, she says medical science and public health experts — and the journalists who cover them — must become better storytellers to get ahead of bad information and to “pre-bunk” false claims that lead to bad decision-making. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Child psychiatrist Victor Carrion has dedicated his career to studying and helping people deal with trauma, especially kids. He says that it is understandable that everyone in the family is dealing with some degree of stress due to COVID-19, and that’s okay. The key is to recognize and acknowledge the stress and deal with it head on.In this episode of Stanford Engineering's The Future of Everything with host, bioengineer Russ Altman, Carrion explains that stress manifests differently at different ages. What works for parent may not for child. He also discusses strategies for minimizing the risk of future post-traumatic stress disorder (PTSD). Carrion counsels trying creative outlets like art and mindfulness techniques like yoga to find what works best to beat stress in these very stressful times. Listen here. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

When humans roamed as hunters and gatherers, the ability to retain calories likely determined who lived and who died in times of famine.Today, that evolutionary advantage may make us prone to diabetes.Join host Russ Altman, professor of bioengineering, and guest Sanjay Basu, a foremost expert in disease prevention, for a broad-ranging discussion of what works, what doesn’t and what new approaches—including an emphasis on community gardens and healthier diets—are on the horizon as society battles this deadly disease. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Imagine being born with just half a heart. Alison Marsden does, pretty much every day. She is an associate professor of pediatrics specializing in cardiology and also of bioengineering. She works with children born with such dire defects.Fortunately for those kids, Marsden is also an expert in computational modeling of cardiovascular system and developer of SimVascular, software that helps surgeons simulate surgeries on the computer without risk to living patients. The software provides researchers and surgeons a way to propose novel surgical procedures and then simulate the resulting blood flow patterns in order to better understand the potential for a successful outcome.Join host Russ Altman and Alison Marsden for an exploration of the many ways computer simulations are making heart surgery more effective and more personal than ever before.You can listen to the Future of Everything on iTunes, Google Podcasts, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Jayodita Sanghvi is director of data science at Grand Rounds, a startup that connects members to high-quality health care. Grace Tang is a data scientist at LinkedIn. Both are alumnae of Stanford bioengineering.While the connection between big data and bioengineering may not be readily apparent, Sanghvi and Tang say that the connection couldn’t be more clear or timely than right now when big data is now firmly entrenched in big business.From applications that help diagnose and guide people to relevant care to programs that suss out bad actors on social media, the challenges of harnessing big data and the consequences of incorrect or improper use are raising important questions for those charged with making big data work. The challenges range from finding correct answers in messy or missing data to the deep ethical and privacy dilemmas inherent in the breadth and quantity of information available today.Join host Russ Altman and big data experts Jayodita Sanghvi and Grace Tang for a deeper look into the challenges arising when big data meets big business.You can listen to the Future of Everything on iTunes, Google Podcasts, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Stanford materials engineer William Chueh got interested in battery design as way to battle climate change. He looked across the energy landscape and understood that a future filled with renewable solar and wind energy will require more and better batteries to even out the troughs when the sun is not shining or the wind is not blowing.Chueh says battery design has come a long way in the last 10 years. But sating the energy needs of a future filled with countless smartphones, laptops, electric cars and wearable devices will drive a profound transition in the battery industry. Today’s $50 billion battery market will blossom to a trillion dollars in the next 15 years, he predicts.Chueh says the grid of the future will be a network of diverse smaller-scale energy-storage options that guarantees a steady supply of electricity with no single point of failure — a model that takes its inspiration from the way the internet delivers information without fail. The result will be a more efficient and resilient grid for all, Chueh says. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Days after COVID-19 broke out in the United States, Russ Altman and colleagues at Stanford's Institute for Human-Centered Artificial Intelligence (HAI) scrambled to organize a full-day online conference to replace the in-person meeting they were planning for spring 2020. Their topic: using AI to defeat the deadly new virus behind COVID-19 and, in particular, analyze how countries were responding; developing new ways of tracking and anticipating its spread; reshape the search for treatments and a vaccine; and, last but not least, to battling “infodemics” — the tendency for information overload to hinder scientific progress. With thousands from around the world tuning in for the live event and 60,000-plus views of the recordings since, the conference illustrated in real terms how an entire field pivoted in a matter of weeks to address the pandemic in new and promising ways. In this episode of Stanford Engineering's The Future of Everything, guest host Howard Wolf turns the tables on Altman — a medical doctor, an expert in bioinformatics and the HAI associate director who helped lead the conference — and digs deep on AI’s response to COVID-19. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The co-director of Stanford’s Institute for Human-Centered Artificial Intelligence discusses how AI can reach its potential to enhance human capabilities and enrich human lives. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

An expert in bioinformatics describes how better information and modeling can help caregivers stay a step ahead of the new virus. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

New research explores how physical pushing and pulling between cells helps them differentiate into the myriad cell types in the body. Have you ever pondered how the cells in your hand knew to become a hand and not, say, a foot or a heart or an ear? Alex Dunn is a chemical engineer who thinks about such things a lot. He has always marveled at the way — from brain to blood to bone — the many cells that make up our bodies derive from just a single cell created when sperm meets egg. He says that process of differentiation comes down to far more than genetics or biochemistry can explain. Dunn counts himself as among an emerging field known as “mechanobiology” that is exploring how physical forces — the tugging and nudging that goes on between cells — play a very important part in how cells differentiate and self-organize into the complex systems that make up the human body. Dunn says there’s still a lot we don’t know about mechanobiology, but the process of observing and analyzing the behavior of invisible molecules inside a cell is not unlike trying to understand how a bakery works by peering in the window. For a glimpse inside the inner workings of human cells and the very latest science of cell differentiation, join chemical-engineer-turned-mechanobiologist Alex Dunn for the latest episode of The Future of Everything podcast from Sirius XM with bioengineer and host Russ Altman. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

A marine scientist travels the world to understand whether and how the ocean will respond to climate change, overfishing and other challenges. Fiorenza “Fio” Micheli grew up on the Mediterranean Sea, where she fell in love with the ocean and made it the object of her scientific career. Now a marine ecologist and co-director of Stanford’s Center for Ocean Solutions, her research spans the spectrum of marine science. She has studied the overfishing of sharks and how their absence affects coral reef ecosystems; she has explored the influence of marine protected areas on biodiversity below the waves; she has studied the impacts of the many ways in which we use the ocean — through fishing to farming to recreation — on its ecosystems, and how to more sustainably support these crucial services. And, for lessons on how undersea life might respond to climate change, she traveled to Italy, her home country, to investigate life near undersea volcanic vents that jet carbon dioxide into the seawater like a Jacuzzi. In all of Micheli’s varied research, she returns to a constant theme: The ocean is a magical place, worthy of awe and wonder, but it is in trouble. It is time to act before it is too late. In the latest episode of Stanford Engineering’s The Future of Everything podcast, Micheli takes host and bioengineer Russ Altman — and listeners — on a deep dive into ocean science and global efforts to protect this valuable resource. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

A civil engineer explains how new insights gleaned from the flight of birds may one day be applied to fields as far-ranging as autonomous cars and crowd control. Anyone who has ever observed a large flock of starlings in flight – darting and swirling as if the entire flock were one big beautiful being – cannot help but marvel and wonder at how all those birds keep from crashing into one another. Nick Ouellette is studying the in-flight behavior of birds to draw lessons he can apply to engineering. He says that birds are not alone in their tightly coordinated patterns of movement; such behaviors can be observed at every scale of nature, from bacteria to bees to beluga whales. Ouellette is doing sophisticated video measurements of flocks in flight to understand just how it is that birds can pull off their beautiful balletics without total chaos. He says the secret is that nature favors decentralized, bottom-up control of groups versus the top-down, leader-follower approach favored by humans. Ouellette, a civil engineer and birdwatcher extraordinaire, discusses his research on the latest episode of Stanford Engineering’s The Future of Everything podcast with bioengineer and host Russ Altman. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

How a revealing father-daughter conversation led to a career dedicated to studying and treating severe trauma and stress-related disorders. Shaili Jain first got interested in studying post-traumatic stress disorder (PTSD) on an East Coast road trip listening to her father describe his experiences during the 1947 Partition of British India. As she listened to details of his trauma and losses, many revealed to her only for the first time, Jain realized she had a deep personal connection to trauma survivors that had, until now, been hidden. This realization spurred a new career, committed to specializing in PTSD and advancing the science of traumatic stress. PTSD became Jain’s life’s work as a medical doctor and a researcher. She would eventually go on to pen a 2019 book, The Unspeakable Mind. Her book combines vividly recounted patient stories, cutting-edge neuroscience, interviews with some of the world ’s top trauma scientists and Jain’s professional expertise, and offers a textured portrait of a widely misunderstood condition. PTSD has historically been hidden in plain sight, she says, and it is typically tough to diagnose and often goes hand in hand with anxiety, mood and substance abuse disorders. But now, she says, researchers are making great strides at understanding trauma and treating PTSD effectively. In the latest episode of Stanford Engineering’s “The Future of Everything” podcast, Jain discusses the hopeful prognosis for traumatic stress disorders with host and bioengineer Russ Altman. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

A rapidly shifting legal debate is raging in healthcare over patient data and privacy. One legal expert says that even though regulations have lagged, a reckoning is due. How much control should patients have over who sees their medical records? How readily should researchers share patient-level data from their clinical studies? In today’s world, should the answers to these questions depend on whether the data are “anonymized?” These are but a few of the ethical and legal conundrums that Michelle Mello, Stanford professor of law and of health research and policy, grapples with on a daily basis. She says that rapidly evolving ways to gather and share medical data are exposing the limitations of laws that protect patient privacy. Meanwhile, the value of sharing patient and clinical data is growing by the day. Data from multiple studies can be pooled to study subgroups or explore rare conditions that were once out of reach. It could help lower drug prices, too, or identify ways to treat patients with greater precision and efficiency. Mello says that reaping these benefits will require a national conversation about what patients are willing to trade off in terms of privacy and control over their personal health information. Join Michelle Mello and host Russ Altman for a wide-ranging discussion of the ethical and legal challenges in healthcare on Stanford Engineering’s The Future of Everything. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

An expert in infectious diseases says that vaccinations are more powerful than ever, but better communication by the medical community is needed to combat misinformation. Stanford professor Yvonne “Bonnie” Maldonado is a medical doctor and an expert in pediatric infectious diseases. She has been fighting and preventing disease her entire career. She says that vaccinations have made remarkable progress in recent years and yet, despite well-known programs that have virtually wiped out once-dreaded diseases like measles, smallpox and polio, a more insidious foe than these diseases has appeared — misinformation that sows confusion, fear and distrust of vaccines in the general public. The result has been a worrying reappearance of some of the diseases society has worked so hard to eradicate. But the science is clear: Vaccinations save lives and carry very little to no risk for the vaccinated. Meanwhile, scientific advances are making vaccines more effective and less risky by the day. There is no magic solution, Maldonado says, but evidence suggests that a more personalized communication approach could help by avoiding stigmatizing naysayers in favor of greater understanding and cooperation with dubious audiences. In working with the public, she says, medical providers remain the first and best line of communication with both the scientific knowledge and the public trust to deliver these life-saving messages. In this episode of Stanford Engineering’s “The Future of Everything” podcast, Russ Altman and vaccination expert Bonnie Maldonado for a clear-eyed look at the future of vaccines. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

The geostationary satellites used for communication and weather forecasting today are very large and very expensive — and most are still functioning perfectly when they must be disposed of because they run out of fuel. In their place, Stanford astronautics professor Simone D’Amico imagines an new era of smaller, less expensive, more efficient satellites that work in tandem to accomplish things their bigger brethren never imagined. He calls it distributed space systems — formations or “swarms” of small satellites.Distributed space systems have breakthrough applications in earth and planetary science, astronomy, and astrophysics, as well as in-orbit servicing and space infrastructure. One task D’Amico foresees for what he calls “The Swarm” is a sort of janitorial role. These “garbage trucks in space” would remove, repair or refuel the thousands of unused satellites orbiting the earth. He says The Swarm could also improve our knowledge of the Sun and its interaction with the upper layers of the atmosphere, leading to better space weather predictions or achieve other important scientific objectives — like detecting life on other planets.Before this space age can be made real, however, D’Amico and his compatriots in astronautics must figure out how to control these distributed space systems with the required precision in safety, and help develop a new set of “galactic” rules to make space traffic sustainable in the long run.Join host Russ Altman and astronautics professor Simone D’Amico for a look at “The Swarm” — the changing face of satellites in space — on the latest episode of The Future of Everything. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Photonics engineers are working toward a day when fast, energy efficient computers do their mathematics using photons — packets of light — instead of electrons. Experts estimate that computers gobble up as much as 10% of global electricity. They predict that that share will only grow as data centers expand and the internet of things brings scads of new computer-controlled devices to the world. Jelena Vuckovic is an electrical engineer who sees a light on the horizon — quite literally. She is building computers that calculate and communicate more with photons than electrons. These “photonic” devices could cut energy consumption in half and empower exciting new technologies, like quantum computing, in the process. Before that day can come, however, Vuckovic and other proponents of photonics — the science of using light for practical purposes — will have to design smaller devices and improve manufacturing techniques to compete with today’s ultra-small electronics. To hasten that arrival, Vuckovic is turning to artificial intelligence to develop new device designs and new materials that could usher in the age of photonics. Join Russ Altman and engineer Jelena Vuckovic for a discussion of the power and promise of photonics on The Future of Everything. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Computer programs that purport to help humans learn have been around almost as long as there have been computer programs, but their track record for success has been less than impressive. Emma Brunskill, an expert on artificial intelligence and machine learning, thinks that less-than-stellar record is about to change and has dedicated her career to finding new and better ways to teach computers to teach humans. Her research creates innovative "reinforcement learning" algorithms in which computers learn through experience to get better at teaching humans. In the process, the algorithms lead people to make better, more-informed decisions that produce better outcomes in the long run. To Brunskill this is no schoolroom affair, but an endeavor where the stakes are high. She says that better education is key to big societal challenges, like alleviating poverty. She believes that better training of new workers — or retraining of older ones — can yield better paying jobs for more people. What’s more, she’s turning her attention to other fields, namely healthcare, where better decisions can have life-or-death implications. Join host Russ Altman and Stanford computer scientist Emma Brunskill for a deep exploration of the new age of computer-assisted learning and decision-making. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

A biomechanical engineer explains how new diagnostics and improved understanding of human movement are yielding great leaps forward in the treatment of motor dysfunction. Engineer Scott Delp first got interested in the details of human movement when he was injured in a skiing accident and spent five years trying to recover. Back then, today’s powerful diagnostic tools, like MRI, weren’t generally available, and Delp experienced many roadblocks and false starts in his recovery. Delp turned that challenging experience into a career studying and developing new approaches to motor dysfunction that he puts to use helping people with conditions like osteoarthritis and cerebral palsy to walk, run and move more easily and without pain. His multidisciplinary team includes surgeons, neurologists, roboticists, engineers and computer scientists who use sophisticated computer models to analyze movement dysfunction and to counteract them through surgery, robotics, neurostimulation and other techniques, including the use of Botox. Delp’s latest focus is on discovering approaches that inspire patients to see better movement as key to better health and view physical rehab not merely as necessary, but actually enjoyable. Join host Russ Altman and expert in the biomechanics of human movement Scott Delp for a “moving” discussion about the joys and the benefits of motion here on The Future of Everything radio show from Sirius XM. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Russ Altman: Today on The Future of Everything, the future of detecting DNA in your blood.Now DNA is the building block of life. It is a relatively simple long molecule or polymer made out of four components or DNA bases which have one letter abbreviations, the famous ATCG, which stand for their chemical names. It’s like a string of beans, beads, beads, but it is long. A human genome is made of about three billion DNA bases, divided into 23 chromosomes. So if you add up the beads in each chromosome, you get about three billion. You get a genome from mom and you get one from dad. So you have two copies of the genome, mostly the same but obviously not identical, or six billion total.Now DNA contains the blueprints for how your cells live, how they grow, how they interact with other cells, and like a computer program, it allows the cell to perform simple computations to make decisions about when and where things happen.If this goes wrong, you can get cancer. Mutations in the DNA cause the computations and decisions to go wrong.Other things can happen too. In the last ten years, researchers have learned that they can detect DNA in the blood. Now we knew that the cells in the blood had DNA, so that was not surprising, but what was surprising is that there is sometimes DNA from other cells in the body, often cells that have died and just released their DNA into the bloodstream. This is sometimes called cell-free DNA because it is floating in the blood and it’s not really part of a cell. Although this may seem like it’s junk, it offers evidence of lots of other processes going on in the body, processes diverse as cancer, pregnancy, stress on organs, or even death and many others.Dr. Stephen Quake is a professor of Bioengineering, Applied Physics and Physics and Stanford University. Steve pioneered the detection of DNA in the blood and some its first applications.Steve, what drove your interest in detecting DNA, and what was the first demonstration that this would actually be useful?Stephen Quake: Well, my interest came actually when I became a father. My wife and I were in to see the doctor, and the doctor says you guys should think about getting amniocentesis. And it was seemed like a theoretical question and something we have time to think about. We said yeah, okay, that sounds like the right thing if recommending it.Russ Altman: And this is a super risky procedure in many ways. A needle goes into the uterus near the baby to extract fluids.Stephen Quake: Big needle right in the mom’s belly, right next to the fetus to try to grab a few cells, and so to do genetic testing. And we said yeah, it sounds like a good idea, thinking we schedule another appointment for it. Next thing we knew, the guy was turning around with a giant needle, plunges it right into my wife’s belly,Russ Altman: Whoa.Stephen Quake: Yeah, whoa, exactly. That was our response. And it’s the response of many people who undergo that certain invasive testing. And not surprisingly, there’s risk associated with doing that testing. Sometimes, you lose the baby and other health problems that might happen.Russ Altman: How far into the pregnancy were you?Stephen Quake: That’s typically done, I don’t know, around 14 weeks, something like that, 15 weeks, somewhere around there. And so that sensitized me to holy cow, there’s a problem here that you’re asking a diagnostic question, and there’s a lot of risk associated with it. And so I began to think are there ways to ask these genetic questions and do diagnostics without adding risk? And I eventually stumbled upon this old scientific literature about this cell-free DNA that you were mentioning, which, as it turns out, was first discovered as a phenomenon in 1948.Russ Altman: That’s before Watson and Crick even articulated the importance of DNA for genetics.Stephen Quake: It’s before the structure, and it’s before people knew. It’s roughly contemporary people first realized that DNA was the molecule of inheritance.Russ Altman: Right.Stephen Quake: Oswald Avery just that same year was working that out. So it was blood chemistry to those guys who did it. But the field stayed alive, and it was mostly people doing cancer research. And eventually, it was figured out that when you’re pregnant, some of the DNA in your blood comes from the fetus, and that was worked out in the late 1970s. And –Russ Altman: And so this is not a large amount, I’m guessing.Stephen Quake: It’s not much, just a few percent of what’s there, so it’s a very challenging measurement problem and the decade-long search to try to figure out how to really use that to build a diagnostic that would allow you to understand the genetics of the baby without having to risk the baby’s life. And we saw that at Stanford, and it was through the work of a really terrific graduate student in my lab when the bioengineering department was young, Christina Fan. And that has now been the first real clinical application of cell-free DNA in diagnostics, and that’s

They make a remarkable array of chemicals to survive the world around them. One engineer is using that knowledge to help people live better. When things aren’t going well for humans and other ambulatory creatures, they simply move on to a new location, a new life. For plants, it’s different, says chemical engineer Elizabeth Sattely, who studies the evolutionary adaptations plants make to survive. Unable to migrate, plants must make do with the hand that’s dealt them. And sometimes that hand is not very good. The soils where they are rooted can lack nutrients or play host to pathogens. The air can be polluted or too arid. This fact of life, however, has given rise to a remarkable breadth of evolutionary adaptations plants use to make the best of their surroundings. They produce powerful small molecules that help them get more nutrients from the soil or air. And, they partner with microbes that help them live. Sattely hopes to better understand and, possibly, employ these adaptations for human benefit by making crops more robust to environmental challenges and by learning how the small molecules plants create impact human health. She says we might even turn plants into biofactories that produce medicines and other valuable chemicals. Join host Russ Altman and Sattely for a deeper look at the remarkable world of plant biochemistry. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

In breast cancer pathology, a 2 percent chance of malignancy is the accepted threshold at which a radiologist refers the patient for further study. In reality, that threshold varies among doctors; some are more conservative, others less so. The result is either more false positives, in which a healthy patient worries unnecessarily they have cancer, or more-worrisome false negatives, in which a patient is told they are fine when they are not.One researcher working to reduce that gap is Stanford’s Ross Shachter. He is a professor of management science and engineering and an expert in using probability to improve decision making. Though Shachter is an engineer, he applies his approaches not to operational efficiency or business management, but to the high-stakes field of mammography, where decisions often have life or death consequences.He says that probability and decision making theory could be integrated into artificial intelligence applications that could help doctors better evaluate patient options, outcomes and preferences to improve care.Join host Russ Altman and Ross Shachter for a look at how engineering and AI are changing the world of breast cancer diagnosis. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In cancer detection, could a blood test replace a biopsy? Once, when a cancer was suspected, the next move often involved a biopsy – literally cutting out human tissue to ascertain malignancy. But that highly invasive model is now being overshadowed by the promise of “liquid biopsies.” In these non-invasive approaches, blood, spinal fluid and other bodily liquids are drawn and tested for the presence of cancer cells, bits of DNA or other molecules that are the unmistakable markers of serious disease. Often, such non-invasive biopsies can be done before clinical symptoms appear. Ash Alizadeh is an authority on the rapidly evolving technologies and techniques of oncology. He says that information is reshaping not only how we detect cancer but also how we treat it. The data we gather about any given cancer is being combined with knowledge about the patients themselves, leading to highly personalized approaches that did not exist just a few years ago. No two cancers, nor two patients, are exactly the same, Alizadeh says. Cancer cells grow differently in each patient and cancer treatments should be personalized accordingly. Join host Russ Altman and Ash Alizadeh as they explore the exciting new age of cancer diagnosis and treatment on this episode of The Future of Everything. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Women face many roadblocks to careers in data science and other STEM disciplines. One Stanford professor is out to change perceptions and realities for women in these fields. It was in 2015 when Margot Gerritsen was asked to speak at a data conference with not a single other woman on the program that she knew that something had to be done to get women into the field. As then-director of the Institute for Computational and Mathematical Engineering (ICME), Gerritsen knew more than a thing or two about data science and became determined to change the male-dominated culture. This determination led to the creation of the wildly popular “Women in Data Science Conference.” In putting the first agenda together, she was insistent that the conference be not about the problematic state of women in the field, but on the exceptional science of the attendees. Now into its fifth iteration, with more than 100,000 participants worldwide, online and at satellite events spreading into six continents, Gerritsen and her co-directors of the conference have inspired women across the planet to enter the sciences and provided a platform for them to highlight their work. In addition to the conference, WiDS now includes a datathon, a podcast that Gerritsen hosts, and ongoing education programs. The results have been, quite literally, life changing for many. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

How do new technologies and techniques for altering DNA get used? And who gets to use them? In recent years, the development of inexpensive genetic sequencing and easy gene editing technologies has given rise to a community of non-academic, amateur researchers who like to refer to themselves, only half-jokingly, as “biohackers.” But, says Mildred Cho, a research professor who has published frequently about bioethics, such communities are not bound by traditional “first-do-no-harm” ethical norms that professional biologists and physicians adhere to. There is, for instance, a group of such do-it-yourself researchers pursuing a low-cost insulin substitute that is free of patent protection; they hope to bring that life-saving medicine to millions who cannot afford it. On the flip side, Cho says, there are also bio-hobbyists who like to do things “just for fun” that could present considerable danger to society. “Would you want your neighbor recreating polio in his garage?” she asks, rhetorically, adding that these deep and challenging concerns are better addressed sooner rather than later. Join bioethicists Mildred Cho and The Future of Everything host Russ Altman for a provocative discussion about the shifting landscape in the ethics of biological research. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

An expert on air quality talks about the hidden dangers inside our homes and offers some helpful tips on what you can do to reduce your exposure. We all know about the decades-long battle to improve air quality outdoors, but Stanford environmental engineer Lynn Hildemann says that while much progress has been made in that regard, it may have caused us to look past the pollutants in our own homes. Hildemann, who studies air pollution and its effects inside and outside the home, says that chemicals and microparticles from cooking, furniture, carpets, cleaning products and good-old household dust represent the latest air quality battleground. She says it’s such a big concern because most Americans spend some 90 percent of their lives indoors. Hildemann offers a few small steps we can all take to improve air quality at home. Using the ventilation hood when cooking is a great first step. Opening the windows whenever possible is another. And, opting for easily cleanable hardwood floors over carpet can help, too. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

A mechanical engineer explains how more and better data is helping to create new prosthetics unlike any before. For years prosthetic limbs were merely functional devices, but recent advances in robotics and neuroscience are transforming the very meaning of the word "prosthetic." Steve Collins is a mechanical engineer who is helping to lead that transformation to the benefit of people who've had an amputation, stroke or battlefield injury. The field has come a long way since the days of strap-on wooden legs. Collins says that, rather than trying to merely mimic what the body does, he's working on new ways of discovering prosthetic limb designs that outperform unimpaired bodies. His team uses advanced robotic systems that record and analyze the wearer's response, continually tuning their mechanical assistance to optimize performance and make them better than ever before. Join host Russ Altman and Steve Collins for a glimpse into the changing world of prosthetics on the latest episode The Future of Everything radio show. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Russ Altman: Today, on The Future of Everything, the future of the microbiome. Now, the microbiome has gotten a lot of attention in the last few years. Now, what is a microbiome? I guess we will learn more, but for the purposes of this discussion, it’s the full set of microbial organisms, chiefly bacteria, but maybe others, that live in different niches within our body. Our mouth, nasal cavity, skin folds, everywhere that has contact with the outside world. The gut microbiome is one of those microbiomes and it’s the community of bacteria living in our digestive system, not necessarily related to disease, but as a normal part of our physiology. We have long known that there is a lot of bacteria in our digestive tract and we know, for example, that they help us digest our food. That’s what we were taught in medical school many decades ago when I was in medical school. We also know that when we treat infections with antibiotics, it can alter these species because these species are sitting in your gut and they also can be very susceptible to antibiotics. So when I treat a patient for urinary tract infection or for pneumonia, not only am I killing the bacteria, hopefully, that’s causing the infection, but I’m probably altering the microbiome of that patient in ways that might lead to some symptoms. They might have some digestive issues that are associated with that antibiotic. Now, it’s become clear that the bacteria living in our gut have much more complicated relationship with our health and with our disease. They seem to be involved in our immune system. They seem to be changing sometimes in both acute and chronic disease. The idea has even emerged that there’s a healthy microbiome, the set of bacteria that you would love to have and host in your bowel and that there might be treatments for some diseases that involve changing the microbiome to get it to be more healthy, so to speak. This has gotten probably the most publicity in the idea of fecal transplants. Yes, if you’re not familiar with that, you heard correctly. This is the idea where poop, forgive the terminology, the technical terminology, poop from healthy people is introduced into the digestive tract of people with disease in order to help them normalize their microbiome to hopefully get it back into a healthy state. So this is getting serious. Ami Bhatt is a Professor of Medicine and Genetics at Stanford University. She has a medical specialty of hematology and studies the human microbiome, mostly in the gut, and has developed new ways to measure the presence of bacteria in the human body and ways to interpret these for health and disease. Ami, you specialize in hematology, the study of blood and blood diseases. How does a hematologist get interested in bacteria that live in the gut? Ami Bhatt: So, thanks a lot for having me, Russ. It’s a pleasure to be here. I actually first became interested in the bacteria viruses and fungi that live in and on us, as I think many young people did which was by watching a TV show. I remember being about, I don’t know, nine or ten years old, and I was left at home for the first time, for like ten minutes by myself or something like that, and so I turned on the TV. My younger brother and I were watching a television show about germs and, they showed these horrifying microscopic images of all of the bacteria that are squirming around everywhere. And I thought, “Wow, this is fantastic and also very gross, and we should really learn more about this.” If you fast forward many years later, part of the reason I became interested as a hematologist and oncologist in viruses and bacteria was because I learned that viruses can cause cancers in some cases. And as you well know, there are viruses that cause well-known cancers like liver cancer. Liver cancer is caused, in some cases, by a hepatitis virus. We know that the human papilloma virus causes cervical cancer and other cancers. And I thought, “Wow, there are all of these relatively simple organisms. They don’t have many genes.” You know, a virus can’t even live by itself. It requires a human cell in these cases in order to replicate. It’s amazing that such simple organisms can alter the biology of such complex organisms like us. That was how I ended up getting interested in bacteria viruses and fungi that live in and on us. Of course, first I learned about them as kind of bad guys but there are trillions of microorganisms that live in and on us and most of them are probably not bad guys. Many of them are probably actually quite helpful and so I’ve taken a more holistic view of what bugs mean to us. Russ Altman: So tell me, what are we finding when we look at the microbiome? How many of these are old friends that we’ve known for years and how many surprises are there where we’re saying, “Wow, we had no idea that this bacteria species was living in us.” And then how do we figure out what they’re doing, good or bad? Ami Bhatt: Yeah, this is an incredibly complex question in

Once the core American curriculum meant reading, writing and arithmetic, but Stanford professor Mehran Sahami says we might soon have to add a fourth skill to that list, “coding.” Sahami thinks deeply about such matters. He’s the leading force behind recent changes in Stanford’s computer science curriculum. He notes that it may not be surprising that more students are choosing to major in computer science than ever before, but what might turn heads is the changing face and intellectual landscape of the field. With concerted effort, more women and minorities, and even students from traditional liberal arts and sciences backgrounds, are venturing into computer science. Sahami says coding has become more than just videogames, social media and smartphone apps. The field is an intellectual endeavor taking on the biggest issues of our day. And in pursuit of tackling big issues, computer professionals also need to be aware of ethical issues that arise, such as the implications of data-driven decision making, respect for personal privacy, the long-term impacts of artificial intelligence and autonomous systems, and the role of large platforms like Google, Facebook and Apple on free speech issues. Sahami says that computers and algorithms are now part of the fabric of everyday life and how the future plays out will depend upon realizing more cultural and gender diversity in computer science classrooms and encouraging multidisciplinary thinking throughout computer science. Join host Russ Altman and expert in computer science education Mehran Sahami for an inspiring journey through the computer science curriculum of tomorrow. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Russ Altman: Today, on The Future of Everything the future of Silicon Valley. Periodically, in human history every now and then there is an unusual mix of opportunity, capital, talent, technology in a geographical region that concentrates this and creates perhaps an unusual period of creativity, invention and sometimes great impact on a global scale. Far beyond, what you might expect from that local geography. I like to think about the Italian Art Renaissance in the 15th and 16th century, focused in Florence. So, removed from Rome, the seat of Italian power and the church power. The Medici family and others provided capital. There was a network of business connections there was a good supply of marble, and paint supplies. And, things were advancing, and then a few masters Giotto, da Vinci, Michelangelo emerged from this pool of kind of opportunity as masters. They integrated the lessons from the past, they added their own vision and there was this revolution in art that seemed to advance from static 2-D depictions, mostly of bible scenes to dynamic three-dimensional art that many people, even today are captivated by. Books have been written about Florence. Why then? Why there? We’re not gonna do that today. But I love that it is related to the Bubonic plague. And the fact that one-third of European people died from this terrible disease. But that took pressure off the farmers who could then produce extra food. Yadda yadda yadda. Now, we have the growth of Silicon Valley. Now, I don’t wanna push this too hard. This was not an art, and it’s not clearly about art, or about cultural things. But there was digital technologies and there’s a somewhat parallel story. Removed from the seats of power in Washington D.C and New York. The power and influence. There was this West Coast place which actually even 50 years ago was mostly fruit farms. But companies arose, Hewlett Packard, Intel. There was this University, Stanford University. Disclaimer: I’m an employee of Stanford University that provided a growing technological work force in both engineering and science. These masters weren’t artists — far from it. Although, well we could discuss that. But they were industrialists. You had Hewlett and Packard, you had the Gordon Moore, and the Intel founders. Steve Jobs and then of course Jerry Yang from Yahoo!, Sergey Brin, Larry Page. And recently now we know about the founders of Facebook, Uber, Twitter, etc. A remarkable concentration of talent, opportunity, technology. Creating a singularity, you could argue that in this area that was just a fruit farming area. So, Silicon Valley perhaps has helped usher in an era of AI, machine learning and the gig economy. Now, as I said I don’t want to oversell this analogy and let’s also remember what happened to Florence. It did not maintain its preeminence in art. Wars and important changing trade patterns reduced the available capital, reduced it as the center of the world in many ways. The reformation changed the religious dynamics. The Catholic church had various reactions against humanism. The pendulum and perhaps the luck of Florence ran out. And Florence became once again a local geographic region. It’s great to visit, it’s great to eat there but it is not really particularly, the center of anything right now. What does the future hold for Silicon Valley? John Markoff is a fellow, former fellow at the Stanford Center for Advanced Study and Behavioral Sciences. He’s a current fellow and research affiliate at the Human-centered Artificial Intelligence Institute at Stanford. He has been a science writer at the New York Times for more than 20, 30 years. He’s covered the general computer industry, Silicon Valley in particular during this time that I just described of great innovation and disruption both in good and bad ways. John, you have written that Silicon Valley may be over optimistic, both at the rate of expected future progress, and also the benefits that that progress will bring to society. Perhaps it’s peddling some things. How do you see this manifesting? And is it a byproduct of hyperbolic marketing, purely? Or does it indicate potentially the beginning of the end for this period of Silicon Valley flourishing innovation. John Markoff: Boy, I love your analogy to Florence. Because I think about that a lot and I think about it particularly in the context of fragility. How fragile is the Valley. Nothing lasts forever. Clearly the arc of technological innovation in the last couple of centuries has been from east to west. There’s always the implication that it may continue to go west perhaps to China. You know, the question of where Silicon Valley came from is a really interesting one as well — you brought that up — what’s new, I mean I always thought there’s a lot of serendipity. I mean Shockley came here — Russ Altman: Right. John Markoff: — famously because his mother was here. What if his mother had been in Iowa? Russ Altman: Exactly. John Markoff: And then there’s th

Computers are everywhere and humans are engaging with them in nearly everything they do. Knowing this, the question becomes: How do we design a world around us so that technology makes life better, not worse? James Landay, an expert in human-computer interaction, says the key to thoughtfully integrating humans with digital technology is to put people first. This perspective draws on a philosophy known as human-centered or user-centered design. Within this approach, the first priority is to understand the problem vexing a particular population by observing, interviewing, and working with that population. Only once the problem is clear does the development of a solution begin. Typically, engineers and technologists have done the opposite. They’ve worked to develop the coolest technology they can think of, and then once it’s ready look around for a way to use it. With human needs at the forefront, Landay’s research focuses on finding ways to use artificial intelligence technology to augment human performance. His current projects range from leveraging technology to encourage positive behavior change, to enabling kids to stay engaged in their education, to helping professionals stay healthy while feeling more connected to their co-workers and workplace. Tune in to this episode of The Future of Everything to hear more about how Landay draws on user-centered design to develop technology that supports human needs. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Biomedical data scientist Sylvia Plevritis is an expert in computational modeling of cancer risk and treatment options hidden in the remarkable quantity of data available today. Rarely is a tumor made up of a single mutation, she says, but more commonly of a mix of different mutations. Such heterogenous tumors may require complex combinations of drugs to produce the most effective treatments. That’s where computers can help. Using mathematical simulations, Plevritis is helping patients and their doctors understand the genetic makeup of a given cancer for the purpose of identifying drug combinations that stand a better chance of success. Some of the models Plevritis works with can be run in an hour or less and yet return invaluable guidance that can save a patient’s life. Plevritis says these computational approaches can even help those without cancer understand their inherent genetic risks to assess whether and when additional screening or risk-reducing interventions are warranted. Join host Russ Altman and biomedical data scientist Sylvia Plevritis as they dive into the promising intersection of computers and cancer care. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Political scientist Jeremy Weinstein has worked at both the White House and the United Nations. In both jobs, he encountered the ethical and policy concerns that new technologies can present to policymakers. As one example, he points to the fierce debate between Apple and national security experts over end-to-end encryption and the challenges investigators faced in accessing data on the iPhones of the perpetrators of a terrorist attack in San Bernardino in 2015. He wants universities, like Stanford, to educate a new breed of engineer that he refers to as a “civic-minded technologist.” These engineers would consider ways in which technological advances could serve the public good, while also thinking critically about the impacts of new technologies on society. In this spirit, Weinstein and two Stanford colleagues, Rob Reich and Mehran Sahami, have begun teaching a new course on the ethics and policy of technology to a large number of undergraduate CS majors. He says it’s critical that these nascent technologists learn from the start to think about the larger implications of their work – even before they write a single line of code. This is because code itself is not value neutral, and technologists must be able to recognize what values are being encoded in the programs they write as well as the competing values that might be traded off. This kind of preparation, he says, will help us as a society to more effectively realize the benefits and minimize the potential harms inherent in new technologies. In his own research, Weinstein is applying his unique perspective to challenges of global poverty and human migration, where, he says, advances in artificial intelligence and machine learning are changing our understanding of two of society’s fundamental problems. Join host Russ Altman and political scientist Jeremy Weinstein for an in-depth look at the ethical and political implications of technology. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Once avoidance was the only answer, but a leading allergist says that advances in desensitizing allergies are challenging common convention. Food allergy expert Kari Nadeau, MD, PhD, says that as many as one in ten adults in the U.S. has a food allergy, many without knowing it. With consequences that range from mild to serious (including lethal anaphylaxis), it is imperative that medical scientists become better adept at spotting food allergies and ultimately at helping patients cope with allergies. Nadeau notes that while a cure remains elusive, it’s a "moonshot issue" worthy of pursuit. She has seen positive results with incremental desensitization therapies that build a patient's tolerance for foods that cause allergic reactions. In addition, new gene therapies are just emerging that are offering a glimmer of promise for those whose diets and lifestyles have been impacted by food allergies. Join host Russ Altman — once allergic to seafood but now able to indulge in lobster thanks to desensitization therapy — and allergist Kari Nadeau for a look ahead at the hopeful future for people with severe food allergies. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.