
🧬 Why 40% of Venture Funds Failed Last Year (And How to Avoid It) | Krish Ramadurai (2/4)
"I was not like, 'Well, this partner helped me on it, and then we shared the deal.' I was like, 'I think I'm good at this because I basically did the output of an entire firm by myself, like, the first two years.'" In this episode of The Biotech Startups Podcast, host Jon Chee continues his conversation with Krish Ramadurai, exploring his unconventional journey from Harvard academia to becoming a venture capital partner in record time. Krish shares how he applied his research training to venture capital, identifying a new category of compute-driven biotech companies before "TechBio" even existed, and executing twelve investments during his first year as an analyst—all while the COVID-19 pandemic sent markets into free fall. Krish reveals the critical importance of "shot-calling" in venture capital, explaining why many talented associates and principals get stuck in their careers by not claiming ownership of their wins. He describes compressing his MBA into sixteen months at Washington University while working two full-time positions, his rapid ascent from analyst to partner by consistently performing above his role, and the uncomfortable but necessary transition from technical expert to fundraiser when dealing with limited partners. Throughout the conversation, Krish emphasizes breaking traditional rules when conviction demands it, treating every investment like an evidence-based academic experiment, and understanding that in venture capital, you're only as good as your last deal.
The Biotech Startups Podcast · Excedr
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Show Notes
- Evidence-Based Venture Capital: Applying academic research methodology to investment diligence and thesis development during COVID-19 market uncertainty
- Identifying TechBio Before It Existed: Market mapping compute-driven biotech companies and building a comprehensive thesis workbook that led to investments in Insilico Medicine, Red AI, and others
- The Art of Shot-Calling: Why claiming ownership of your wins is critical for advancing from analyst to partner, and how many VCs get stuck by sharing credit
- Accelerated Career Progression: Navigating the venture capital hierarchy by doing work above your pay grade and forcing conversations about promotion through demonstrated results
- The LP Fundraising Reality: Transitioning from technical diligence to selling yourself as a jockey to institutional investors, understanding emerging versus established fund dynamics
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