Science TLDR
98 episodes — Page 1 of 2
Episode 96: Reddit Trending — The dietary fibre content of fruit and vegetable kitchen preparation waste and UK consumers’ dietary fibre-related attitudes regarding its consumption
Nov 7, 202610 min
Episode 95: Shared α-helix chimeraffibodies enable linker-free bispecific protein design
Nov 4, 202611 min
Episode 94: Reddit Trending — The Effect of Deactivating Facebook and Instagram on Users’ Emotional State
Nov 1, 202610 min
Episode 93: Reddit Trending — Associations of food processing and dietary risk factors with colorectal cancer incidence in the NIH-AARP Diet and Health Study: A cohort study
Oct 23, 202611 min
Episode 92: Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism
Oct 19, 202611 min
Episode 91: Reddit Trending — “It’s Like You’re Trying to Defuse a Bomb”: <i>Fear, Responsibility, and Shame in Young Men’s Sexual Lives</i>
Oct 18, 202610 min
Episode 90: Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition
Oct 13, 20269 min
Episode 89: Reddit Trending — Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the Power of the Purse
Oct 9, 20269 min
Episode 88: GPCR antagonism via rewiring of receptor trafficking and degradation
Oct 7, 202611 min
Episode 87: Reddit Trending — Did Donald Trump Receive a Mandate for Sweeping Change in 2024?
Oct 6, 202610 min
Episode 86: Specific targeting of MR1-antigen complexes using nanobodies
Oct 5, 202611 min
Episode 85: Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits
Oct 4, 202610 min
Episode 84: Reddit Trending — Predictors and prevalence of support for white nationalism in the United States
Oct 3, 202610 min
Episode 83: Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex
Sep 26, 202611 min
Episode 82: Trending — Substantial under-detection of human rabies cases in the United States
Sep 25, 202610 min
Episode 81: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability
Aug 25, 202623 min
Episode 80: Trending — Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata
Jul 22, 202615 min
Episode 79: Trending — Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study
Jul 16, 202621 min
Episode 78: Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation
Jul 6, 202621 min
Episode 77: Trending — People prefer to negotiate with women, even when outcomes are identical and gender is unknown
Jun 26, 202619 min
Episode 76: Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors
Jun 15, 202620 min
Episode 75: Trending — A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone
Jun 12, 202618 min
Episode 74: Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow
Jun 9, 202611 min
Episode 73: Trending — Work from Home and Disability Employment
Jun 5, 202622 min
Episode 72: From free speech advocates to critics: The Trump administration’s new rhetoric promotes support for censorship among Trump voters
Jun 2, 202619 min
Episode 71: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
Jun 1, 202622 min
Episode 70: Language Modeling Materializes a World Model of Protein Biology
May 27, 202619 min
Episode 69: Novel bispecific T-cell engagers overcoming acquired EGFR resistance
May 25, 202621 min
Episode 68: The lived experience of rejection sensitivity in ADHD - A qualitative exploration
May 22, 202623 min
Episode 67: Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery
May 18, 202621 min
Episode 66: The political polarization of health outcomes in the USA
May 15, 202619 min
Episode 65: Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager
May 11, 202621 min
Episode 64: Climate-driven depopulation and adaptation realities in America’s coastal ground zero
May 8, 202623 min
Episode 63: Engineering of acidic pH-responsive anti-CD3 binding antibodies
May 4, 202621 min
Episode 62: Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study
May 1, 202623 min
Episode 61: Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology
Apr 24, 202620 min
Episode 60: A trophoblast glycoprotein specific 5 T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies
Apr 22, 202622 min
Ep 59A trispecific antibody engaging T cells with tumour and myeloid cells augments antitumour immunity
https://doi.org/10.1038/s41551-025-01569-4
Dec 24, 202511 min
Ep 58Language models cannot reliably distinguish belief from knowledge and fact
https://doi.org/10.1038/s42256-025-01113-8
Nov 7, 202514 min
Ep 57Spatially organized inflammatory myeloid-CD8+ T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment
https://doi.org/10.1101/2025.06.06.657162
Nov 6, 202519 min
Ep 56SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
https://doi.org/10.1038/s41586-025-09655-y
Oct 28, 202516 min
Ep 55Guidelines for Early Food Introduction and Patterns of Food Allergy
https://doi.org/10.1542/peds.2024-070516
Oct 22, 202514 min
Ep 54Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design
https://doi.org/10.1080/19420862.2025.2570748
Oct 16, 202515 min
Ep 53A genetic common factor underlying self-reported math ability and highest math class taken
https://doi.org/10.1038/s41380-025-03237-0
Oct 11, 202516 min
Ep 52Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition
https://doi.org/10.1021/acs.biochem.5c00274
Sep 15, 202513 min
Ep 52The impact of CD3 affinity-attenuation on T cell engaging bispecific antibodies: is it really that simple?
DOI: 10.1080/17460441.2025.2522088
Sep 12, 202517 min
Ep 51Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
https://doi.org/10.1016/j.cell.2025.07.046
Aug 29, 202519 min
Ep 50Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
https://doi.org/10.1038/s41586-025-09370-8
Aug 26, 202520 min
Ep 49AlphaEarth Foundations: An embedding field model for accurate and efficient global mapping from sparse label data
arXiv:2507.22291v1
Aug 6, 202518 min
Ep 48Single-Chain Fab Chain-Exchange (scFab-PACE) converts targeted prodrugs into functional T cell engagers on tumor cells
https://doi.org/10.1016/j.jbc.2025.110490
Aug 5, 202516 min