Science TLDR
76 episodes — Page 1 of 2
Episode 74: Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow
Episode 73: Trending — Work from Home and Disability Employment
Episode 72: From free speech advocates to critics: The Trump administration’s new rhetoric promotes support for censorship among Trump voters
Episode 71: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
Episode 70: Language Modeling Materializes a World Model of Protein Biology
Episode 69: Novel bispecific T-cell engagers overcoming acquired EGFR resistance
Episode 68: The lived experience of rejection sensitivity in ADHD - A qualitative exploration
Episode 67: Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery
Episode 66: The political polarization of health outcomes in the USA
Episode 65: Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager
Episode 64: Climate-driven depopulation and adaptation realities in America’s coastal ground zero
Episode 63: Engineering of acidic pH-responsive anti-CD3 binding antibodies
Episode 62: Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study
Episode 61: Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology
Episode 60: A trophoblast glycoprotein specific 5 T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies
Ep 59A trispecific antibody engaging T cells with tumour and myeloid cells augments antitumour immunity
https://doi.org/10.1038/s41551-025-01569-4
Ep 58Language models cannot reliably distinguish belief from knowledge and fact
https://doi.org/10.1038/s42256-025-01113-8
Ep 57Spatially organized inflammatory myeloid-CD8+ T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment
https://doi.org/10.1101/2025.06.06.657162
Ep 56SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
https://doi.org/10.1038/s41586-025-09655-y
Ep 55Guidelines for Early Food Introduction and Patterns of Food Allergy
https://doi.org/10.1542/peds.2024-070516
Ep 54Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design
https://doi.org/10.1080/19420862.2025.2570748
Ep 53A genetic common factor underlying self-reported math ability and highest math class taken
https://doi.org/10.1038/s41380-025-03237-0
Ep 52Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition
https://doi.org/10.1021/acs.biochem.5c00274
Ep 52The impact of CD3 affinity-attenuation on T cell engaging bispecific antibodies: is it really that simple?
DOI: 10.1080/17460441.2025.2522088
Ep 51Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
https://doi.org/10.1016/j.cell.2025.07.046
Ep 50Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
https://doi.org/10.1038/s41586-025-09370-8
Ep 49AlphaEarth Foundations: An embedding field model for accurate and efficient global mapping from sparse label data
arXiv:2507.22291v1
Ep 48Single-Chain Fab Chain-Exchange (scFab-PACE) converts targeted prodrugs into functional T cell engagers on tumor cells
https://doi.org/10.1016/j.jbc.2025.110490
Ep 47Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement
https://doi.org/10.1016/j.celrep.2025.115965
Ep 46Navigating protein landscapes with a machine-learned transferable coarse-grained model
https://doi.org/10.1038/s41557-025-01874-0
Ep 46Sliding Window Interaction Grammar (SWING): a generalized interaction language model for peptide and protein interactions
https://doi.org/10.1038/s41592-025-02723-1
Ep 45Predicting human decisions with behavioural theories and machine learning
https://doi.org/10.1038/s41562-025-02267-6
Ep 44Tuning antibody stability and function by rational designs of framework mutations
https://doi.org/10.1080/19420862.2025.2532117
Ep 43Lying increases trust in science
https://doi.org/10.1007/s11186-025-09635-1
Ep 42Soil and cherry bacterial communities predict flavor on coffee farms
https://doi.org/10.1038/s41598-025-03665-6
Ep 41What Is It Like to Be a Bat?
https://www.jstor.org/stable/2183914
Ep 403 Papers on Antibody Tumor Penetration and Clearance
Mixing it up a little with an episode covering 3 papers on the same topic.Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearancedoi:10.1016/j.addr.2008.04.012.A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumorshttps://doi.org/10.1016/j.ymthe.2022.04.013.Influence of molecular size on tissue distribution of antibody fragmentshttps://doi.org/10.1080/19420862.2015.1111497
Ep 39Why people follow rules
https://doi.org/10.1038/s41562-025-02196-4
Ep 38Cross-tissue multicellular coordination and its rewiring in cancer
doi: 10.1038/s41586-025-09053-4
Ep 37Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity
https://doi.org/10.1038/s41586-025-08997-x
Ep 36Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER
https://doi.org/10.1038/s41587-025-02654-4
Ep 35Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease
DOI: 10.1056/NEJMoa2504747
Ep 34Adversarial testing of global neuronal workspace and integrated information theories of consciousness
https://www.nature.com/articles/s41586-025-08888-1
Ep 33Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
https://doi.org/10.1038/s41586-025-08852-z
Ep 32A natural experiment on the effect of herpes zoster vaccination on dementia
DOI: 10.1038/s41586-025-08800-x
Ep 31The end of the genetic paradigm of cancer
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003052
Ep 30Embodied large language models enable robots to complete complex tasks in unpredictable environments
https://www.nature.com/articles/s42256-025-01005-x
Ep 29Sequencing by Expansion (SBX) – a novel, high-throughput single-molecule sequencing technology
https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1
Ep 28CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells
DOI: 10.1158/2643-3230.BCD-23-0258
Ep 27AlphaFold prediction of structural ensembles of disordered proteins
DOI: 10.1038/s41467-025-56572-9Key Points:- Introduces AlphaFold-Metainference, a new method combining AlphaFold predictions with physics simulations- Notable because AlphaFold was trained on structured proteins but shows surprising accuracy with disordered ones- Validated against experimental data from 11 different disordered proteins using SAXS (small-angle X-ray scattering)- Further validated against detailed simulations of two neurodegenerative disease-related proteins (Abeta and alpha-synuclein)Major Implications:- Could revolutionize study of disordered proteins involved in diseases like Alzheimer's and Parkinson's- Suggests AlphaFold may be detecting fundamental principles of protein behavior beyond just structured proteins- Opens new possibilities for drug discovery and personalized medicine- May require rethinking our definition of protein "disorder"Technical Details:- AlphaFold provides distance predictions between amino acids- Limited to predictions up to ~22 angstroms- Metainference uses physics simulations to explore possible conformations within AlphaFold's predictionsLimitations Discussed:- 22 angstrom distance prediction limit means some longer-range interactions may be missed- Particularly relevant for very extended disordered regions- May need integration with other experimental techniques for complete picture