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Science TLDR

Science TLDR

Raymond Ruff

98 episodesEN

Show overview

Science TLDR has been publishing since 2024, and across the 2 years since has built a catalogue of 98 episodes. That works out to roughly 25 hours of audio in total. Releases follow a fortnightly cadence.

Episodes typically run ten to twenty minutes — most land between 11 min and 20 min — though episode length varies meaningfully from one episode to the next. None of the episodes are flagged explicit by the publisher. It is catalogued as a EN-language Science show.

The show is actively publishing — the most recent episode landed 2 days ago, with 37 episodes already out so far this year. The busiest year was 2025, with 47 episodes published. Published by Raymond Ruff.

Episodes
98
Running
2024–2026 · 2y
Median length
15 min
Cadence
Fortnightly

From the publisher

Ten-minute paper summaries for scientists and experts.Two episodes a week: Mondays feature the top-scoring paper from a curated weekly digest of T cell engager, bispecific antibody, and protein engineering literature. Fridays cover the top trending paper on PubMed — any field, whatever's catching the research community's attention that week.Hosted by Raymond Ruff, a protein scientist working in translational immunotherapeutics. Audio is generated with NotebookLM; the host prompt aims for measured scientific skepticism rather than hype.Feedback and paper suggestions: [email protected]

Latest Episodes

View all 98 episodes

Episode 96: Reddit Trending — The dietary fibre content of fruit and vegetable kitchen preparation waste and UK consumers’ dietary fibre-related attitudes regarding its consumption

Nov 7, 202610 min

Episode 95: Shared α-helix chimeraffibodies enable linker-free bispecific protein design

Nov 4, 202611 min

Episode 94: Reddit Trending — The Effect of Deactivating Facebook and Instagram on Users’ Emotional State

Nov 1, 202610 min

Episode 93: Reddit Trending — Associations of food processing and dietary risk factors with colorectal cancer incidence in the NIH-AARP Diet and Health Study: A cohort study

Oct 23, 202611 min

Episode 92: Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Oct 19, 202611 min

Episode 91: Reddit Trending — “It’s Like You’re Trying to Defuse a Bomb”: <i>Fear, Responsibility, and Shame in Young Men’s Sexual Lives</i>

Oct 18, 202610 min

Episode 90: Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition

Oct 13, 20269 min

Episode 89: Reddit Trending — Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the Power of the Purse

Oct 9, 20269 min

Episode 88: GPCR antagonism via rewiring of receptor trafficking and degradation

Oct 7, 202611 min

Episode 87: Reddit Trending — Did Donald Trump Receive a Mandate for Sweeping Change in 2024?

Oct 6, 202610 min

Episode 86: Specific targeting of MR1-antigen complexes using nanobodies

Oct 5, 202611 min

Episode 85: Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits

Oct 4, 202610 min

Episode 84: Reddit Trending — Predictors and prevalence of support for white nationalism in the United States

Oct 3, 202610 min

Episode 83: Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex

Sep 26, 202611 min

Episode 82: Trending — Substantial under-detection of human rabies cases in the United States

Sep 25, 202610 min

Episode 81: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability

Aug 25, 202623 min

Episode 80: Trending — Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata

Jul 22, 202615 min

Episode 79: Trending — Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study

Jul 16, 202621 min

Episode 78: Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation

Jul 6, 202621 min

Episode 77: Trending — People prefer to negotiate with women, even when outcomes are identical and gender is unknown

Jun 26, 202619 min
Raymond Ruff 2023