Research To Practice | Oncology Videos

Inside the Issue: Optimizing the Management of Metastatic Pancreatic Cancer | Faculty Presentation 1: Selection and Sequencing of Therapy for Metastatic Pancreatic Cancer CME information and select publications

Optimizing the Management of Metastatic Pancreatic Cancer | Faculty Presentation 2: Current and Future Role of Biomarker-Based Decision-Making for Metastatic Pancreatic Cancer CME information and select publications

Featuring perspectives from Dr Eileen O'Reilly and Dr Zev Wainberg, including the following topics: Introduction (0:00) Selection and Sequencing of Therapy for Patients with Metastatic Pancreatic Cancer (11:42) Ongoing Clinical Trials (31:33) Current and Future Role of Biomarker-Based Decision-Making in Metastatic Pancreatic Cancer (41:04) CME information and select publications

Inside the Issue: The Current and Future Role of CD20 x CD3 Bispecific Antibodies in the Management of Non-Hodgkin Lymphoma | Faculty Presentation 2: Key Data Sets with Bispecific Antibodies in Diffuse Large B-Cell Lymphoma and Other Non-Hodgkin Lymphoma Subtypes — Martin Hutchings, MD, PhD CME information and select publications

Inside the Issue: The Current and Future Role of CD20 x CD3 Bispecific Antibodies in the Management of Non-Hodgkin Lymphoma | Faculty Presentation 1: Role of Bispecific Antibody Therapy in Follicular Lymphoma — Loretta J Nastoupil, MD CME information and select publications

Featuring perspectives from Professor Martin Hutchings and Dr Loretta J Nastoupil, including the following topics: Introduction (0:00) Follicular Lymphoma (2:42) Diffuse Large B-Cell Lymphoma (35:41) CME information and select publications

Featuring perspectives from Prof Georgina Long, including the following topics: Introduction: (0:00) Journal Club with Prof Long – Part 1 (7:56) Case: A man in his mid 70s presents with bilateral painfully inflamed red ears and is diagnosed with BRAF V600E-mutated metastatic melanoma — Joanna Metzner-Sadurski, MD (27:19) Case: A man in his early 70s with past medical history of diabetes, hypertension, chronic obstructive pulmonary disease and several skin cancers is diagnosed with BRAF wild-type Stage IIIA melanoma — Helen H Moon, MD (32:52) Case: A man in his late 50s with past medical history of Stage III melanoma and multiple metastatic recurrences responds to single-agent pembrolizumab — Warren S Brenner, MD (43:02) Case: A man in his mid 70s develops metastatic recurrence of melanoma after relatlimab/nivolumab on clinical trial and pembrolizumab therapy for Stage III BRAF V600K-mutated melanoma — Priya Rudolph, MD (50:48) Case: A woman in her mid 30s with a personal and family history of melanoma develops multiple axillary nodes with BRAF-mutated melanoma without a primary lesion — Dr Moon (58:18) CME information and select publications

Featuring perspectives from Dr Corey J Langer, Dr Ticiana Leal, Dr Karen Reckamp and Dr Jacob Sands, including the following topics: Optimal use of front-line immune checkpoint inhibition for metastatic non-small cell lung cancer (NSCLC) (00:00) Case: A man in his late 60s with NSCLC, no actionable mutations, PD-L1 20%, who received second-line datopotamab deruxtecan as part of a clinical trial (12:29) Case: A man in his early 70s with metastatic NSCLC, PD-L1 30%, who received first-line chemotherapy with pembrolizumab followed by maintenance pembrolizumab and second-line ramucirumab/pembrolizumab after disease progression (29:29) Case: A man in his mid 60s, PD-L1 60% and no actionable mutations who received first-line single-agent pembrolizumab followed by the addition of chemotherapy and chemotherapy/immunotherapy maintenance for NSCLC (40:23) Case: A woman in her late 60s with NSCLC, PD-L1 60%, with complete response in the liver and lung to second-line tumor treating fields with atezolizumab (57:18) Current Management of NSCLC After Disease Progression on Anti-PD-1/PD-L1-Containing Regimens — Dr Langer (1:10:48) Potential Role of Novel Immunotherapy-Based Combination Strategies in Progressive Advanced NSCLC – Dr Reckamp (1:30:14) TROP2 and Novel Antibody Drug Conjugates Under Evaluation in NSCLC – Dr Sands (1:53:36) Other Promising Therapeutic Strategies for Patients with Progressive Metastatic NSCLC – Dr Leal (2:18:58) CME information and select publications

Featuring perspectives from Dr Ghassan Abou-Alfa and Dr Daneng Li, including the following topics: Introduction: Etiology of Hepatocellular Carcinoma (HCC) and IO Response (0:00) First-Line Therapy for Advanced HCC — Dr Abou-Alfa (17:42) Second- and Later-Line Therapy for Advanced HCC; Emerging Considerations for Patients with Resectable HCC — Dr Li (38:12) CME information and select publications

Inside the Issue: Exploring the Current and Future Management of High-Risk, Hormone-Sensitive Nonmetastatic Prostate Cancer | Faculty Presentation: Treatment Intensification for Patients with Locally Advanced and Biochemically Recurrent Prostate Cancer — Neal D Shore, MD CME information and select publications

Featuring perspectives from Dr Neal D Shore and Dr Mary-Ellen Taplin, including the following topics: Introduction (0:00) Key Data Sets (8:18) Faculty Survey (39:50) CME information and select publications

Featuring perspectives from Dr Michael Wang, including the following topics: Algorithm for observation versus initiation of therapy for newly diagnosed mantle cell lymphoma (MCL) (0:00) First- and second-line therapy approaches for MCL (7:26) Case: A 45-year-old woman with relapsed MCL receiving acalabrutinib who develops severe headaches (10:21) Current role of ibrutinib in the treatment of MCL; use of single-agent venetoclax and of zanubrutinib in the treatment algorithm (14:59) Case: A 68-year-old man presenting with an enlarged spleen, no lymphadenopathy and a white blood cell count of 300,000 is diagnosed with MCL (17:48) Case: A 71-year-old man with multiregimen-relapsed, nodular type MCL presents with lymphadenopathy and a 3-cm tumor near the mediastinum (22:38) Patient selection for chimeric antigen receptor T-cell therapy (25:59) Novel and investigational therapeutic approaches for MCL (30:11) Treatment approaches for other histological variants of MCL (39:00) CME information and select publications

Featuring a slide presentation and related discussion from Dr Michael Wang, including the following topics: Overview of Bruton tyrosine kinase (BTK) inhibitors and clinical data establishing the efficacy of these agents for mantle cell lymphoma (MCL) (0:00) Clinical investigation of ibrutinib in the front-line setting; results from the Phase III SHINE trial and voluntary market withdrawal of ibrutinib for MCL (4:36) Phase III TRIANGLE trial of ibrutinib combined with chemotherapy as upfront therapy for younger patients with MCL; role of autologous stem cell transplant (11:14) Acalabrutinib and zanubrutinib for the treatment of relapsed/refractory (R/R) MCL (14:16) Key findings from the BRUIN trial leading to the FDA approval of pirtobrutinib for R/R MCL (16:23) CME information and select publications

Featuring perspectives from Dr Richard F Riedel, including the following topics: Introduction: (0:00) Case: A woman in her late 20s with multiregimen-recurrent metastatic alveolar soft part sarcoma after treatment with multiple VEGF tyrosine kinase inhibitors and a single-agent PD-1 inhibitor receives axitinib/pembrolizumab — Nam Bui, MD (4:14) Case: A man in his mid 60s with metastatic dedifferentiated chondrosarcoma of the right femur undergoes resection and receives doxorubicin/cisplatin followed by maintenance pembrolizumab — IDH2 and TERT promoter mutations, PD-L1 2+ by IHC — Melanie B Thomas, MD (10:06) Case: A man in his early 30s with an asymptomatic "bulge on abdomen" found to be a 6.2-cm mass receives a diagnosis via biopsy of desmoid fibromatosis. Local treatment team recommends surgery — Dr Bui (22:20) Case: A woman in her early 40s with a history of familial adenomatous polyposis undergoes surgical excision of 3 colon cancer lesions followed by adjuvant capecitabine. On follow-up she is found to have a rapidly enlarging mass abutting the iliac and mesenteric vessels. Fine needle aspiration shows desmoid tumor — Dr Bui (29:37) Case: A man in his mid 30s with a protruding mass on his back diagnosed as a desmoid tumor receives sorafenib followed by second-line liposomal doxorubicin — Atif M Hussein, MD, MMM (33:29) Case: A man in his mid 50s with multiregimen-recurrent metastatic mediastinal liposarcoma receives resection, chemotherapy and eribulin — CDK4 amplification identified by next-generation sequencing (NGS) — Dr Thomas (39:31) Case: A man in his late 60s with abdominal pain and weight loss is diagnosed with metastatic high-grade myxoid liposarcoma of the retroperitoneum — Dr Hussein (43:06) Case: A woman in her late 50s diagnosed with Grade 2 leiomyosarcoma develops a recurrence 3 years after resection and adjuvant doxorubicin/ifosfamide — Dr Hussein (47:34) Case: A woman in her early 60s presents to the ER with shortness of breath and is diagnosed with unresectable leiomyosarcoma of the mediastinum — Dr Bui (51:48) Case: A man in his mid 40s diagnosed with gastrointestinal stromal tumor (GIST) receives neoadjuvant imatinib followed by resection, then adjuvant imatinib — KIT exon 9 mutation identified by NGS — Dr Bui (54:13) Case: A man in his mid 60s with mesenteric recurrence of abdominal GIST experiences transaminitis with imatinib — microsatellite stable, no actionable mutations by NGS — Dr Thomas (58:40) CME information and select publications

Featuring an interview with Dr Jeremy Abramson, including the following topics: Choice of Bruton tyrosine kinase (BTK) inhibitor as first-line therapy for chronic lymphocytic leukemia (CLL) (0:00) Perspectives on the use of chemoimmunotherapy versus BTK inhibitors as front-line treatment for CLL (2:31) Chimeric antigen receptor (CAR) T-cell therapy-associated ICANS (immune effector cell-associated neurotoxicity syndrome) and infectious complications in patients with CLL (6:21) Available data with bispecific antibodies for CLL (9:38) Sequencing CAR T-cell therapy and pirtobrutinib for patients with previously treated CLL (11:09) Integrating bispecific antibodies into community-based practice; strategies for mitigating associated toxicities (14:25) CD20 versus CD19 as a therapeutic target in lymphomas (20:31) First-line treatment selection for patients with mantle cell lymphoma (23:07) Chemotherapy combined with nivolumab or with brentuximab vedotin as initial therapy for Hodgkin lymphoma (30:12) CME information and select publications

Featuring a slide presentation and related discussion from Dr Jeremy Abramson, including the following topics: Long-term follow-up data with Bruton tyrosine kinase (BTK) inhibitors as monotherapy for chronic lymphocytic leukemia (CLL): The CLL12 and SEQUOIA trials (0:00) Extended follow-up results with venetoclax combined with anti-CD20 antibodies or a BTK inhibitor for CLL: The CLL14, MURANO and GLOW trials (5:27) Primary analysis of the TRANSCEND CLL 004 trial evaluating lisocabtagene maraleucel for relapsed/refractory (R/R) CLL (12:40) Genomic evolution and resistance to pirtobrutinib in patients with covalent BTK inhibitor-pretreated CLL in the Phase I/II BRUIN study (16:24) Chimeric antigen receptor (CAR) T-cell therapy data with axicabtagene ciloleucel and lisocabtagene maraleucel for R/R follicular lymphoma (FL) (18:24) Bispecific antibodies as treatment for R/R FL: mosunetuzumab, epcoritamab, odronextamab and TNB-486 (22:57) Novel treatment approaches for mantle cell lymphoma (MCL): First-line acalabrutinib/rituximab and lisocabtagene maraleucel for R/R disease (32:54) Updated results from studies evaluating loncastuximab tesirine, such as LOTIS-2, and CAR T-cell therapy, such as TRANSFORM and ZUMA-7, for R/R diffuse large B-cell lymphoma (39:29) Ongoing follow-up from pivotal trials of bispecific antibodies for large B-cell lymphomas (46:01) SWOG-S1826: Results from the Phase III trial evaluating nivolumab with doxorubicin/vinblastine/dacarbazine (AVD) versus brentuximab vedotin with AVD for advanced-stage classic Hodgkin lymphoma (51:48) CME information and select publications

Featuring an interview with Dr Rana R McKay, including the following topics: Prostate Cancer (0:00) Renal Cell Carcinoma (22:58) Urothelial Bladder Cancer (52:18) CME information and select publications

Featuring perspectives from Dr Adiyta Bardia and Dr Erika Hamilton, including the following topics: Introduction: Biopharmacology and Endocrinology of Breast Cancer (0:00) Current Strategies for Previously Treated ER-Positive Metastatic Breast Cancer (mBC) — Dr Bardia (12:15) Future Directions in the Management of ER-Positive mBC — Dr Hamilton (33:16) Clinical Investigator Survey (51:50) CME information and select publications

Inside the Issue: Current and Future Management of ER-Positive Metastatic Breast Cancer After Disease Progression on a CDK4/6 Inhibitor | Faculty Presentation 2: Future Directions in the Management of ER-Positive mBC — Erika Hamilton, MD CME information and select publications

Inside the Issue: Current and Future Management of ER-Positive Metastatic Breast Cancer After Disease Progression on a CDK4/6 Inhibitor | Faculty Presentation 1: Current Strategies for Previously Treated ER-Positive Metastatic Breast Cancer (mBC) — Aditya Bardia, MD, MPH CME information and select publications

Featuring perspectives from Dr Hans Lee and Dr Saad Zafar Usmani, including the following topics: Introduction (0:00) Biology/Immunology; Overview (3:05) Current Available Data (19:40) Clinical Investigator Survey (33:11) Combinations/Ongoing Trials (55:40) CME information and select publications

Inside the Issue: Integrating Bispecific Antibodies into the Management of Multiple Myeloma — Patient Selection and Toxicity Management | Faculty Presentation 1: Available Data with and Potential Clinical Role of Bispecific Antibodies for Multiple Myeloma (MM) CME information and select publications

Inside the Issue: Integrating Bispecific Antibodies into the Management of Multiple Myeloma — Patient Selection and Toxicity Management | Faculty Presentation 2: Tolerability and Other Practical Considerations with Bispecific Antibodies for MM CME information and select publications

Featuring perspectives from Dr Matthew Gubens, including the following topics: Investigator perspectives on emerging findings with immunotherapy for resectable non-small cell lung cancer (NSCLC) (0:00) Immunotherapy for early-stage unresectable disease (7:51) First-line therapy for patients with metastatic NSCLC with and without targetable mutations (17:46) Current and potential roles of antibody-drug conjugates in the treatment of NSCLC (21:55) Emerging biomarkers in small cell lung cancer research (26:45) CME information and select publications

Featuring a slide presentation and related discussion from Dr Matthew Gubens, including the following topics: Early-stage non-small cell lung cancer (NSCLC) with an EGFR mutation (0:00) Management of metastatic NSCLC with an EGFR mutation (6:34) Prognostic and predictive implications of plasma circulating tumor DNA for first-line therapy for metastatic NSCLC with a HER2 mutation (12:18) Emerging findings with immunotherapy for resectable NSCLC (13:36) Immunotherapy for early-stage unresectable disease (23:14) Emerging data with immunotherapy for metastatic NSCLC (26:00) Tumor treating fields with standard therapy for metastatic NSCLC after platinum failure (35:38) Patient-reported outcomes and emerging results with durvalumab-based therapies for extensive-stage small cell lung cancer (44:51) CME information and select publications

Featuring perspectives from Dr Omid Hamid and Dr Evan J Lipson, including the following topics: Introduction: Immunology of Melanoma (0:00) Melanoma (8:26) Cutaneous Squamous Cell Carcinoma (43:15) Basal Cell Carcinoma and Merkel Cell Carcinoma (52:55) CME information and select publications

Year in Review: Clinical Investigator Perspectives on the Most Relevant New Data Sets and Advances in Melanoma and Nonmelanoma Skin Cancers | Faculty Presentation 2: Localized Melanoma and Other Types of Skin Cancer — Evan J Lipson, MD CME information and select publications

Year in Review: Clinical Investigator Perspectives on the Most Relevant New Data Sets and Advances in Melanoma and Nonmelanoma Skin Cancers | Faculty Presentation 1: Metastatic Melanoma — Omid Hamid, MD CME information and select publications

Featuring a slide presentation and related discussion from Dr Philip A Philip, including the following topics: Comprehensive biomarker analysis for patients diagnosed with colorectal cancer (CRC) (0:00) Selection and sequencing of systemic therapy for patients with metastatic CRC (11:48) Prevalence of claudin-18.2 in patients with locally advanced or metastatic gastric or gastroesophageal junction cancer (22:31) Emerging systemic therapies for hepatocellular carcinoma (24:49) Management of advanced biliary tract cancers (30:04) Activity of NALIRIFOX (liposomal irinotecan/oxaliplatin/leucovorin/fluorouracil) for treatment-naïve metastatic pancreatic cancer (35:35) CME information and select publications

Featuring an interview with Dr Philip A Philip, including the following topics: Comprehensive biomarker analysis for patients diagnosed with colorectal cancer (CRC) (0:00) Selection of first-line therapy for patients with metastatic CRC (mCRC) (7:51) Therapeutic options for patients with HER2-positive mCRC (10:10) Patient selection for regorafenib and/or TAS-102 with or without bevacizumab for mCRC (16:57) Selection and sequencing of therapeutic options for patients with unresectable or metastatic gastric or gastroesophageal junction cancer (19:52) Current and emerging immune checkpoint inhibitor-based combinations for hepatocellular carcinoma (24:51) First- and later-line therapy for patients with advanced biliary tract cancers (33:17) Activity of NALIRIFOX (liposomal irinotecan/oxaliplatin/leucovorin/fluorouracil) for treatment-naïve metastatic pancreatic cancer (36:12) CME information and select publications

Featuring perspectives from Dr Neeraj Agarwal, Dr Emmanuel S Antonarakis, Prof Karim Fizazi and Dr Susan F Slovin, including the following topics: Introduction: Current landscape of prostate cancer treatment (0:00) Relevance of homologous recombination repair mutations in castration-resistant prostate cancer: Treatment with PARP inhibitors as monotherapy — Dr Antonarakis (12:33) Phase III PROpel and MAGNITUDE trials — Dr Slovin (35:44) PARP inhibitor combination treatments for advanced prostate cancer — Dr Agarwal (57:08) Future directions in the use of PARP inhibitors for prostate cancer — Prof Fizazi (1:23:49) Journal Club (1:35:53) Case discussions (2:11:57) CME information and select publications

Featuring a slide presentation and related discussion from Dr Floor J Backes, including the following topics: Recent updates from ASCO 2023 in the management of ovarian cancer (0:00) Recent updates from ASCO 2023 in the management of endometrial cancer (36:08) Recent updates from ASCO 2023 in the management of cervical cancer (41:48) CME information and select publications

Featuring perspectives from Dr Floor J Backes, including the following topics: Available data with and clinical investigator perspectives on trastuzumab deruxtecan for the management of gynecologic cancers (0:00) Patient-specific factors guiding treatment selection and sequencing for ovarian cancer (OC) (6:05) Management of adverse events associated with PARP inhibitor maintenance therapy for OC; safety concerns in the later-line setting (15:00) Management approaches for ocular toxicity and other adverse events associated with mirvetuximab soravtansine (20:28) Current role of upifitamab rilsodotin in the management of OC and available data with tumor treating fields (24:38) Investigator perspectives on the current chemotherapy shortage; recently published Phase III data with chemoimmunotherapy for endometrial cancer (29:11) Tisotumab vedotin for cervical cancer (36:34) CME information and select publications

Featuring perspectives from Dr Terence Friedlander and Prof Petros Grivas, including the following topics: Introduction (00:00) First-line treatment of metastatic urothelial bladder cancer (22:39) Second-line therapy and beyond (41:34) CME information and select publications

Inside the Issue: Optimizing the Management of Metastatic Urothelial Bladder Cancer | Faculty Presentation 2: Available Data with, Ongoing Investigation of and Role of Other Novel Strategies for mUBC — Petros Grivas, MD, PhD CME information and select publications

Inside the Issue: Optimizing the Management of Metastatic Urothelial Bladder Cancer | Faculty Presentation 1: Immunotherapy-Based Strategies for Metastatic Urothelial Bladder Cancer (mUBC) — Terence Friedlander, MD CME information and select publications

Featuring perspectives from Dr Heather McArthur, including the following topics: Investigator perspectives on recently presented data from clinical trials for HER2-positive localized and metastatic breast cancer (mBC) (0:00) Racial and ethnic differences in 21-gene Recurrence Score® and survival among patients with ER-positive breast cancer (28:31) Emerging data with CDK4/6 inhibitors for ER-positive, HER2-negative breast cancer (38:22) Final overall survival analysis from the TROPiCS-02 study of sacituzumab govitecan for ER-positive, HER2-negative mBC; TROP2 mRNA expression and association with clinical outcomes (1:03:22) CME information and select publications

Inside the Issue: Novel Agents, Approaches and Strategies in the Management of Higher-Risk Myelodysplastic Syndromes — Faculty Presentation 2: Future directions in the management of higher-risk MDS — Dr David Sallman CME information and select publications

Inside the Issue: Novel Agents, Approaches and Strategies in the Management of Higher-Risk Myelodysplastic Syndromes — Faculty Presentation 1: Current management of higher-risk myelodysplastic syndromes (MDS) — Guillermo Garcia-Manero, MD CME information and select publications

Featuring perspectives from Dr Guillermo Garcia-Manero and Dr David Sallman, including the following topics: Introduction (00:00) Biology of Acute Myeloid Leukemia/Myelodysplastic Syndromes (3:14) Assessment of Risk Status (14:17) Oral Hypomethylating Agents (HMAs) (22:24) HMA/Venetoclax; Other Combinations (31:26) Magrolimab/TP53 (45:12) CME information and select publications

Featuring a slide presentation and related discussion from Dr Hanny Al-Samkari, including the following topics: Indications for initiation of treatment for patients with immune thrombocytopenia (ITP) and selection of first-line therapy (0:00) Treatment algorithm for ITP in the second line and beyond (7:47) Role of thrombopoietin receptor agonists and fostamatinib for second- and later-line treatment of ITP (14:21) Novel investigational approaches for the treatment of ITP — efgartigimod, rilzabrutinib and ianalumab (28:24) CME information and select publications

Featuring perspectives from Dr Hanny Al-Samkari, including the following topics: Case: A woman in her mid 60s with a past medical history of hypertension and Sjögren's syndrome presents to emergency with diffuse petechiae in her extremities and the taste of iron in her mouth (0:00) Case: A man in his early 30s with chronic immune thrombocytopenia (ITP) who has been off therapy for 18 months with no constitutional symptoms presents for his 3-month follow-up with platelet count decreased to 29 x 109/L (3:26) Case: A woman in her mid 60s with chronic ITP who has received multiple treatments over a decade and is resistant to splenectomy presents for follow-up with a platelet count of 11 x 109/L (5:58) Characterizing immune dysfunction in patients with ITP (7:45) Perspectives on the approach to initial therapy for ITP (12:23) Treatment approaches beyond first-line therapy (17:34) Addressing symptoms and concerns beyond the issue of bleeding for patients with ITP (22:19) Role of splenectomy in the treatment of ITP (27:08) CME information and select publications

Featuring perspectives from Ms Kristen B Battiato and Dr Jennifer Woyach, including the following topics: Introduction (0:00) Case: A woman in her early 70s responding to ibrutinib for 4 years (27:07) Case: A woman in her early 80s with TP53-mutant, del(17p) disease responding to acalabrutinib (38:02) Case: A man in his mid 50s with chronic lymphocytic leukemia/small lymphocytic leukemia treated for a year with obinutuzumab followed by venetoclax; no evidence of disease for 3 years (43:29) Case: A Cuban woman in her mid 60s with multiregimen-recurrent disease, now receiving venetoclax (53:17) NCPD information and select publications

Featuring perspectives from Dr Carlos M de Castro, including the following topics: Overview of paroxysmal nocturnal hemoglobinuria (PNH) (0:00) Complement C5 inhibition for patients with PNH (6:48) Proximal complement inhibitors for PNH management (17:17) CME information and select publications

Featuring perspectives from Dr Carlos M de Castro, including the following topics: Biology of paroxysmal nocturnal hemoglobinuria (PNH) (0:00) Evolution of the PNH treatment landscape (13:07) Selection and sequencing of therapies for patients with PNH (18:09) Overview and presentation of extravascular hemolysis (23:50) Case: A woman in her early 40s with PNH who developed Budd-Chiari syndrome and had an excellent response to C5 inhibition (26:57) Case: A woman in her early 40s with a suboptimal response to ecluizumab followed by an excellent response to pegcetacoplan on the PEGASUS trial (34:00) Case: A woman in her mid 40s who experienced breakthrough hemolysis with pegcetacoplan and was recently switched to iptacopan (38:40) CME information and select publications

Featuring perspectives from Dr David F McDermott and Dr Sumanta Kumar Pal, including the following topics: Introduction (0:00) ASCO 2023 (1:35) Management of Advanced Renal Cell Carcinoma (RCC) (17:19) Treatment Approaches for Nonmetastatic RCC; Optimal Care of Patients with Non-Clear Cell RCC (38:13) CME information and select publications

Featuring perspectives from Dr Bradley J Monk and Dr Matthew A Powell, including the following topics: Introduction (0:00) First-Line Therapy for Advanced Endometrial Cancer (EC) — Dr Powell (7:32) Current Options for Relapsed EC; Promising Investigational Agents and Strategies — Dr Monk (32:39) Clinical Investigator Survey (43:41) CME information and select publications

Featuring perspectives from Dr Yelena Y Janjigian, Dr Manish A Shah and Dr Harry H Yoon, including the following topics: Integration of Immune Checkpoint Inhibitors into the Management of HER2-Negative Gastroesophageal (GE) Cancers Introduction (0:00) Adjuvant immunotherapy for GE cancers (1:54) First-line anti-PD-1/PD-L1 antibody-based regimens for metastatic HER2-negative GE cancer (13:11) Future role of novel immunotherapies/checkpoint inhibitors (20:57) Optimal Management of HER2-Positive GE Cancers Selection of first-line therapy for metastatic HER2-positive GE cancer (28:37) Selection of second-line therapy for metastatic HER2-positive GE cancer (36:56) Therapeutic Options for Relapsed/Refractory GE Cancers; Novel Investigational Approaches Selection of second-line therapy for metastatic HER2-negative GE cancer (42:11) Zolbetuximab/chemotherapy as first-line therapy for claudin 18.2-positive metastatic GE cancer (43:09) Use of circulating tumor DNA assays for patients with GE cancers (53:37) CME information and select publications

Featuring perspectives from Dr Emmanuel S Antonarakis, Prof Karim Fizazi, Dr Rana R McKay, Dr Alicia K Morgans and Dr A Oliver Sartor, including the following topics: Current Management of Nonmetastatic Prostate Cancer Introduction (0:00) Case: A man in his early 70s diagnosed with localized prostate cancer who underwent a radical prostatectomy in 2010 experiences rising prostate-specific antigen (PSA) from 0.18 to 0.4; PSA doubling time 7 months; PSMA PET-negative for other sites of disease — David S Morris, MD (1:26) Case: A man in his early 70s with M0 hormone-sensitive prostate cancer (HSPC) with PSA persistence after radical prostatectomy received androgen deprivation therapy (ADT) intensification with abiraterone/prednisone and went to the ER with hypertension, palpitations, headache and abnormal liver function tests — Sandy Srinivas, MD (15:58) Faculty presentation: Dr Morgans (19:29) New Considerations in Treatment Intensification for Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) Case: A man in his mid 60s with localized prostate cancer and biochemical recurrence 5 years after neoadjuvant and adjuvant leuprolide and intensity-modulated radiotherapy to the whole pelvis — Neeraj Agarwal, MD, FASCO (28:59) Case: A man in his early 80s who underwent radical prostatectomy 15 years ago and received radiotherapy and ADT for biochemical recurrences is now diagnosed with M0 castration-resistant prostate cancer with quickly rising PSA levels — Dr Morris (33:02) Faculty presentation: Prof Fizazi (41:54) Available and Emerging Strategies for Newly Diagnosed Metastatic Castration-Resistant Prostate Cancer (mCRPC) Discussion (53:41) Case: A man in his mid 60s diagnosed with metastatic HSPC and PSMA positivity in the pubic ramus, bilateral external iliac nodes and lungs — Dr Srinivas (57:03) Faculty presentation: Dr McKay (1:03:01) Identification and Management of mCRPC with a Homologous Recombination Repair (HRR) Gene Abnormality Case: A man in his early 50s with mCRPC after enzalutamide receives olaparib; somatic BRCA2 mutation; TP53 mutation on liquid biopsy — Dr Agarwal (1:18:21) Case: A man in his early 70s with high-grade localized prostate cancer treated with proton beam therapy and ADT for 2 years now has rising PSA and CT scan positive for retroperitoneal node; somatic BRCA2, TP53, FOXA1 and MEN1 mutations; microsatellite stable — Dr Morris (1:21:59) Faculty presentation: Dr Antonarakis (1:30:22) Management of Progressive mCRPC Case: A man in his late 70s with multiregimen-refractory mCRPC and a gBRCA2 mutation receives olaparib with a sustained response for several years — Dr Srinivas (1:43:10) Faculty presentation: Dr Sartor (1:48:35) CME information and select publications

Featuring perspectives from Dr Ian W Flinn, including the following topics: Hodgkin Lymphoma Introduction (0:00) Case: A man in his late 30s with well-controlled HIV and newly diagnosed Stage IV classic Hodgkin lymphoma receives brentuximab vedotin with doxorubicin/vinblastine/dacarbazine (AVD) — Neil Morganstein, MD (2:30) Case: A man in his early 60s with classic Hodgkin lymphoma with a left lower lung mass and extensive regional lymphadenopathy receives brentuximab vedotin with AVD on the Phase III SWOG-S1826 trial — Ranju Gupta, MD (6:45) Mantle Cell Lymphoma (MCL) Case: A man in his late 50s with newly diagnosed MCL blastoid variant — Zanetta S Lamar, MD (16:27) Case: A man in his mid 50s with newly diagnosed Stage IV MCL — Shams Bufalino, MD (21:23) Follicular Lymphoma Case: A man in his mid 60s with incidental diagnosis of Grade IIIA follicular lymphoma after admission to the hospital for a stroke — Bhavana (Tina) Bhatnagar, DO (36:28) Case: A woman in her late 30s with extensive lymphadenopathy is diagnosed with Grade I/II follicular lymphoma and receives bendamustine/rituximab — Dr Morganstein (39:04) Diffuse Large B-Cell Lymphoma (DLBCL) Case: A physically independent man in his early 80s with DLBCL and multiple comorbidities, including cardiac issues and peripheral neuropathy, experiences disease progression after R-GCVP — Syed F Zafar MD (49:53) Case: A man in his mid 70s who presented with rapidly progressive proptosis of the left eye is diagnosed with DLBCL and receives R-CHOP and methotrexate CNS prophylaxis — Dr Lamar (55:21) CME information and select publications