124. Metastatic HER2- positive breast cancer
Oncology for the Inquisitive Mind · Michael Fernando and Josh Hurwitz
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Show Notes
Metastatic HER2-positive breast cancer continues to dominate headlines, and new therapeutic options continue to be found for those afflicted with the disease. Before trastuzumab (anti-HER2 therapy), the overall survival for this cohort of patients was less than two years. As technology and treatments changed, it can boast an extended survival well beyond five years in numerous studies, with many patients responding far more than that number.
This week, we will discuss two exciting and pioneering studies. The first looks at tucatinib, a tyrosine kinase inhibitor with known results in those with intracranial disease. The second is the use of abemaciclib in hormone receptor-positive, HER2-positive breast cancer in patients previously treated with trastuzumab.
Links to studies discussed in this episode (subscription may be required):
HER2CLIMB: Link
monarcHER: Link
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Art courtesy of Taryn Silver
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