
LONGEVITY with Nathalie Niddam
463 episodes — Page 1 of 10
#466: Breast Cancer: The Hidden COSTS & Radical Resilience (Secrets On Recovery, Team-Building & Nutrition REVEALED) | With Dr. Laura James
#465: Personalizing GLP-1 Medications: The Role of Genetics in Weight Loss and Side Effects With Noura Abul-Husn M.D. Ph.D
#464: Brain POWER: The Creatine Revolution, Exercise Snacks, and the Age of Energy | Dan Pardi
#463: Reducing Breast Cancer Risks | HRT, Imaging, AI, BRCA, And GLP-1s With Dr. Elisa Port
#462: STOP! Before Detoxing, Mold Doctor Says Do THIS First Or Risk Getting Worse With Dr. Jill Crista
#461:Why Only 8 Proven Interventions Work | Extend LIFE & Healthspan With Science Not Hype With Dr. Bill Lawrence
#460: Most Impactful Pod Moments: Hidden Cancer Markers, Radical Longevity Experiments, EMFs Exposed (and the Mast Cell Dilemma) With Nathalie Niddam & Guests
#459: Why 1 in 5 Women Face Alzheimer's: The BRAIN Health Conversation We've Been Avoiding | Emma Heming Willis & Dr. Nicole Beurkens
#458: Why Hormones, GLP-1s & Statins Aren't Solving the REAL Issue With Dr. Jim LaValle R.Ph.
STOP Chasing Mold Tests: The Smarter Way to Find the Real Problem With Jason Earle I Ep #457
#456: The Bioregulator Debate: What Actually Works (And What Doesn't) With Dr. Marios Kyriazis
#455: Beyond Botox: The EXOSOME Science That Could Change Skincare Forever | Amitay Eshel and Anastasia Khodzhaeva
#454: From Burnout to Balance: Rebuilding Cellular Energy & Getting Out Of Fight Or Flight With Scott Sherr
#453: From ‘Tan Maxing’ To The Growing Debate Over Sunscreen | A Look At Trends & Myths With Dr. Teo Soleymani (Plus GHK-Cu Peptide)
#452: Forget the Diagnosis—Fix the Biology! Reversing "Incurable" Conditions With Alex Kikel
#451: Reimagining Aging: C60’s Role in Muscle Function, Neuroprotection, and Extending Vitality With Ian Mitchell
#450: Lyme, Bartonella & Babesia EXPOSED: Hidden Vectors, Lost Lives, and the Battle for Early Detection With Nicole Bell
#449: I Never Said That!... Dr. Tyna Moore on How Her GLP-1 Microdosing Message Was Misunderstood and What She Actually Recommends
#448: Turning Sugar into Fiber, Hangover Science, and the Truth About Genetically Modified Probiotics | Zack Abbott
#447: Gut AWAKENING: The Silent Epidemic of Spike Protein, Long Covid, and Accelerated Aging | Dr. Robin Rose
#446: The NAD Code: Secrets to ENERGY, Aging, CD38, and Gut Health Breakthroughs With Dr. Andrew Salzman
#445: REVOLUTIONIZING Thyroid Care: The NEW 3-Step Approach to Hashimoto’s | Energy, Focus & Gut Health w/ Dr. Anshul Gupta
#444: Stop Negative Thought Spirals With This Framework | Learn How Rumination Affects Your Health With Donna Jackson Nakazawa
#443:How to Reclaim YOUTHFUL Muscle: Microbes, Sleep, Belly Fat (and the Real Fix for Modern Aging) | Dr. William Davis
#442: The High-Performance Guide to Supplements With Kyal Van Der Leest
#441: Why Mitochondria Matter: Preventing Age-Related Decline and Transforming Women’s Longevity With Dr. Taz Bhatia
#440: The Ultimate Supplement Checklist BEFORE You Buy: Safety, Quality, and Evidence-Based Picks SOLO With Nat Niddam
#439: Reclaiming Metabolism: The SECRET Molecule Transforming Women's Health (Belly Fat, Brain Power & Beyond) With Siobhan Mitchell PhD
#438: You’re NOT Going Crazy: Understanding What’s Going On In Your Body In Your Late 30s - 50s With Andrea Donsky
#437: Unmasking Thyroid Dysfunction: How Optimizing Your Thyroid Transforms Longevity, Mood, and Metabolism With Dr. Amie Hornaman
#436: Is Your Body’s Terrain Hospitable For Cancer? Affordable Lab Tests, Metabolic Flexibility, and Emotional Foundations With Dr. Nasha Winters
#435: FINALLY! A Guide To What YOU Can Do About EMF Exposure To Better Protect Your Body With R Blank
#434: Are You Aging Like Someone Else? (How To Find Your PERSONAL Path to Healthspan) With Sandra Kaufmann
#433: Unlocking ENERGY: Why “Quantum” Isn’t Just Hype — What the Nobel Prize Taught Us | with Todd Shipman
#432: Midlife Wake-Up Call: Why Doing Less Is Important During The Peri- and Menopausal Transition With Cynthia Thurlow
#431: Humic and Fulvic Minerals: Nature’s Solution for Energy, Detox, and Lasting Health With Caroline Alan
#430: Most Impactful Pod Moments This Year: Mitochondrial Transplants, Weight Loss, Resilience Through Trauma, Heart Tests & Tryptophan After COVID
#429: Redefining CANCER: Metabolic Flexibility, Radical Remission, and The One Terrain Shift That Changes Everything With Dr. Nasha Winters
#428: Poop, Peptides & The Power of Microbiome | The Secret Longevity Organ With Dr. Grace Liu
#427: The Hidden Link Between Vision, Longevity & Anxiety | Spatial Empathy, Screens & the 20-20-20 Rule With Dr. Meenal Agarwal
#426: The Invisible Price of Poor Sleep and How To Fix It, Tech Hacks That Save Marriages, and the Longevity Equation — With Melissa Urban
Today, I'm joined by the amazing Melissa Urban, the force behind Whole30 and a global champion of accessible nutrition. In our conversation, Melissa opens up about a surprising discovery in her wellness journey: sleep, not just food, is often the real foundation of long-term health. She shares how overlooked sleep hijacked her cravings, impacted her insulin sensitivity, and even chipped away at her resilience—revealing the invisible costs that only show up years down the line. Visit ozlosleep.com/nat and use code NAT to get $95 off Episode Timestamps: Welcome and podcast introduction ... 00:00:00 Poor sleep's impact on cravings and insulin ... 00:00:47 Melissa Urban's wake-up calls: burnout and disrupted sleep ... 00:00:59 Tech sleep hack: Ozlo noise-canceling earbuds ... 00:01:06 Sleep's effect on diet and insulin sensitivity ... 00:06:42 Cravings, mood, and resilience with sleep loss ... 00:08:49 Melissa Urban's sleep disruption stories: motherhood, book tour, menopause ... 00:10:02 Sleep and technology: SleepBuds saving marriage ... 00:12:42 Sleep consistency as key for resilience and health ... 00:17:47 Chronic light sleep: cognitive and metabolic consequences ... 00:20:09 Hormonal disruption and menopause sleep challenges ... 00:24:42 Sleep refresh tips: environment and habits ... 00:26:07 Screen-free wind-down routines ... 00:27:41 Midlife sleep wisdom: earlier bedtime ... 00:34:37 Physical and mental benefits of good sleep ... 00:36:06 Noise canceling vs. masking: SleepBuds explained ... 00:39:18 Sleep supplements: magnesium, melatonin, CBD ... 00:48:28 One impactful habit: eliminate screens and alcohol ... 00:53:30 Where to find Melissa Urban and Ozlo ... 00:56:27 Our Amazing Sponsors: Vampire Exosome by Young Goose - A next-generation serum packed with three trillion PRP-derived exosomes and RejuvNAD™ to support collagen production and skin renewal at the cellular level—helping results build over time instead of fading fast. Shop at younggoose.com and use code NAT10 MassZymes by BiOptimizers – A full-spectrum digestive enzyme formula with 4x more protease to help break down protein into usable amino acids so your body actually benefits from what you eat—try it risk-free with a 365-day money-back guarantee and save 15% at bioptimizers.com/bionat with code BIONAT. Mitopure Gummies by Timeline - These clinically researched gummies support mitophagy to help renew your mitochondria and boost cellular energy, giving you a stronger biological foundation for resilience—visit timeline.com/NAT to get 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#425: Broccoli Power: The Secret Longevity Molecule (Fighting Toxins, Microplastics & Aging) | Sulforaphane Exposed With David Roberts & Dr. John Gildea
Today, I'm joined by David Roberts and Dr. John Gildea, two passionate researchers whose work sits at the cutting edge of environmental health and longevity science. In this episode, we dive deep into the catalyst for developing a stabilized sulforaphane supplement—something born out of both necessity and relentless curiosity. David opens up about how environmental toxicity stopped being theoretical for him, and Dr. Gildea brings a wealth of clinical insight into why supporting our detox pathways could be a game-changer for chronic disease prevention. Offer: Get 25% off stabilized sulforaphane products for a limited time at mara-labs.com/NAT with code NAT (offer ends April 7th 2026; 15% off thereafter). Episode Timestamps: Welcome and podcast intro ... 00:00:00 When toxins became personal: cancer & environment ... 00:04:54 Practical detox: household and lifestyle changes ... 00:06:12 Sulforaphane's effect on inflammation and daily function ...00:07:07 Finding health solutions outside conventional medicine ... 00:14:44 Cancer diagnosis prompts sulforaphane stabilization ... 00:18:17 NRF2: master regulator in aging, skin, and detox ... 00:24:16 Sulforaphane, curcumin, and inflammation ... 00:25:11 Supplement confusion: sulforaphane vs. glucoraphanin ... 00:31:10 Food as medicine and practical dosing ... 00:34:51 Microplastics: exposure, health risks, and impacts ... 00:35:31 Detox routes and microplastics research ... 00:47:04 Glyphosate, NRF2 suppression, and gut barriers ... 00:52:54 Sulforaphane boosts detox and protects against pollution ... 00:59:13 GLP-1s, muscle loss risk, and supplement alternatives ... 01:00:08 Berberine: sleep, glucose, and microbiome effects ... 01:06:12 Synergies, future research, and sulforaphane limits ... 01:10:32 Sprouts, seeds, and potency of broccoli compounds ... 01:16:17 Our Amazing Sponsors: Vitali SkinCare - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off. Tro Zzz by Troscriptions – a fast-acting, customizable sleep formula designed to quiet racing thoughts and support deeper, more restorative sleep using a powerful blend of GABA-supporting compounds, cannabinoids, and sleep-promoting ingredients. Head to troscriptions.com, use code NAT10, and get 10% off. Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#424: Part 2 - Follow Up To Dr. Bill Lawrence Episode: Answering More Of Your Bioregulator Questions With Nat Niddam & Erin Ryan
Today, I'm joined by Erin Ryan, my producer, for a special follow-up episode where we tackle your most pressing questions about bioregulators and peptides. After the wildly popular Bill Lawrence interview, the Longevity Podcast community sent in a wave of thoughtful queries—from cancer concerns to menopause, sourcing, and practical tips. Click Here for list of BIOREGULATOR NAMES Books mentioned in this episode: The Peptide Bioregulator Revolution (Great primer on bioregulators) Author: Dr. Marios Kyriazis Peptides and the Epigenetic Control of Aging (Technical, science-heavy) Author: PhD Vladimir Khavinson, MD, PharmaB Phil Micans, MS, PhD Alexander Maryanovich, MD Episode Timestamps: Welcome and sponsor introduction ... 00:00:00 Autophagy and Primadene ... 00:00:44 Bioregulator basics and liver support ... 00:01:58 Cancer and telomere lengthening peptides ... 00:05:56 Bioregulators and cancer: caution advised ... 00:08:06 Immune bioregulators and cancer recovery ... 00:12:31 Book reference: "Peptide Bioregulator Revolution" ... 00:13:54 Bioregulators for immune support ... 00:14:44 When not to use bioregulators ... 00:16:56 Menopause, ovarian aging, and bioregulators ... 00:17:47 Clinical outcomes in women ... 00:23:57 GLP-1s and bioregulator absorption ... 00:27:01 Preventative strategies by age ... 00:28:57 Epitalon safety and dosing ... 00:33:18 Bioregulator sourcing and access ... 00:35:41 Amazon caution for supplements ... 00:38:01 Emerging science and trusted brands ... 00:40:03 Social media challenges and newsletter ... 00:44:30 Our Amazing Sponsors: Primeadine by Oxford Healthspan — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout. Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order. http://www.profound-health.com/?Aff=Longevity15 O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#423: Detox Pathways, Sensitive Systems, and the Truth About Chelation Therapy With Dr. Nafysa Parpia
Today, I'm joined by the insightful Dr. Nafysa Parpia, a true leader in environmental and complex chronic illness medicine and the Director of Naturopathic Medicine at Gordon Medical. In our conversation, Dr. Parpia shares how her passion for deep, integrated healing brought her into the world of environmental toxins, hormone health, and the nuanced ways our bodies respond to the modern world. She opens up about her journey, the unique challenges women face—especially during menopause—and why so many aren't finding answers in traditional medicine. Episode Timestamps: Welcome & episode goals ... 00:00:00 Environmental toxins and complex illness ... 00:01:17 Rise of chronic illnesses; environmental triggers ... 00:07:26 Lead, bone loss, and menopause ... 00:10:03 Sources of lead exposure today ... 00:12:03 Chelation therapy: what, when, and how ... 00:14:26 Opening detox pathways: herbs and bioregulators ... 00:17:17 Menopause, toxic burden, and immune shifts ... 00:20:49 CDC data: multiple toxins and cumulative risk ... 00:23:02 Genetics, nutrition, and susceptibility ... 00:28:12 Personalized medicine & system constraints ... 00:30:03 Heavy metals, inflammation, and hormone effects ... 00:35:35 Peptide and bioregulator therapy: sequencing matters ... 00:41:12 Testing mistakes: over- and under-testing ... 00:57:41 Preparing for detox: the Pretox approach ... 01:02:58 Sensitivity to binders and protocol adjustments ... 01:16:50 Plasmapheresis (TPE): science and application ... 01:19:19 Optimizing menopause care and women's self-sovereignty ... 01:25:28 Our Amazing Sponsors: STEMREGEN - A plant-based formula designed to support your body's natural stem cell release, circulation, and repair processes so you can recover and regenerate more effectively. Visit www.stemregen.co/nat and use code NAT15 for your exclusive discount. Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT Youth Daily by Young Goose — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours HERE and use code Nat10 Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#422: Lessons from Centenarians: Immunity, Lifestyle, and Changing the Aging Game With Dr. Jeffrey Bland
Today, I'm joined by the legendary Dr. Jeffrey Bland, widely known as the "father of functional medicine" and a true pioneer in the science of longevity and immune resilience. In this conversation, Dr. Jeffrey Bland opens up about his decades-long journey questioning the conventional medicine model, the personal moments that shaped his mission, and how his passion for asking the right questions ultimately led him to reshape the future of healthcare. Visit Bigboldhealth.com/NAT and get 15% off automatically at checkout. Episode Timestamps: Focus on immune system aging ... 00:00:00 Questioning conventional medicine and the roots of chronic disease ... 00:05:00 Functional medicine and influences like Linus Pauling ... 00:12:39 Dangers of oversimplification and the limits of biohacking ... 00:17:21 Evolving thinking on supplements and the power of cycling and personalization ... 00:19:37 Why immune resilience trumps immune boosting for longevity ... 00:25:21 Diet's impact on immune cell turnover and long-term health ... 00:28:57 Autoimmunity, CHIP cells, inflammaging, and biological individuality ... 00:32:04 Microbiome, mitochondria, and immune-driven fatigue ... 01:00:07 The 4R gut and immune program as a starting point ... 01:06:26 Movement, lymphatics, and rejuvenation ... 01:08:35 Food as information, epigenetics, and practical recommendations ... 01:11:25 90-day immune system renewal and rapid-fire takeaways ... 01:31:40 Our Amazing Sponsors: Quantum Upgrade - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it's easy to try for yourself. Visit quantumupgrade.io/NAT and use code NAT15 to start the free 15 day trial. Primeadine by Oxford Healthspan — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout. PW1 by Puori — A clean, high-quality whey protein that's third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#421: Trauma SCIENCE: How Hidden Stress Hijacks Your Health (Autoimmunity, Brain Inflammation, and Unlocking Resilience) | With Dr. Aimie Apigian
Today, I'm joined by Dr. Aimie Apigian, an innovative leader in the biology of trauma, whose work bridges the worlds of science, medicine, and lived experience. In our conversation, Dr. Apigian opens up about her journey from conventional medicine—where symptom management was the norm—to uncovering the physiological roots of trauma and the crucial role our nervous system plays in resilience and healing. She shares how her own health struggles, her work with adopted children, and a relentless curiosity led her to re-examine everything she thought she knew about stress, autoimmunity, and capacity. The 7-Day Somatic Healing for Stored Emotions - https://traumahealingaccelerated.mykajabi.com/a/2148170319/wdrhGYaY 21-Day Journey, a daily live session program that helps participants understand how much trauma their body may be holding - https://traumahealingaccelerated.mykajabi.com/a/2147704575/wdrhGYaY Episode Timestamps: Introduction, host's mission, and episode theme ... 00:00:00 Science behind trauma, limits of traditional medicine, and autoimmune experiences ... 00:06:11 Attachment, symptom management, functional medicine, and healing journey ... 00:08:17 Mold exposure, state triggers, brain inflammation, and capacity blocks ... 00:14:22 Medical gaslighting, trauma validation, and biological capacity ... 00:18:25 Safety, resilience, and chronic survival state effects ... 00:19:32 Misconceptions about chronic stress—emergency brake and vagus nerve ... 00:22:27 Attachment patterns, autoimmunity, and shrinking world ... 00:28:47 Chronic survival loop, exhaustion, coping strategies, and shutdown ... 00:31:11 Moving to repair: phases of healing and gentle approaches ... 00:34:08 Somatic practices, art therapy, and different expressions of trauma ... 00:39:01 Shifts in sleep, digestion, anxiety, and felt safety ... 00:42:06 Tracking nervous system state: strategies and awareness ... 00:46:41 Therapy limitations: biology and somatic integration ... 00:48:42 Retraining vs. managing symptoms, stabilization, and healing ... 00:54:53 Capacity, resilience, lessons from centenarians, and longevity ... 01:00:06 Trauma's impact on mitochondria, telomeres, and generational health ... 01:06:27 Gut microbiome and trauma: two-way connection ... 01:08:03 Our Amazing Sponsors: Manukora Honey - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to MANUKORA.com/NAT to save up to 31% plus $25 in free gifts with the Starter Kit. Mitopure Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to timeline.com/nat20 for 20% off Mitopure Gummies. Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#420: Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 With Leslie Kenny
Today, I'm joined by the inspiring Leslie Kenny, Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable. Leslie has a generous offer for you, when you visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout you'll get 20% off. Episode Timestamps: Welcome, show intro, and overview ... 00:00:00 Leslie Kenny's health journey and reversing disease ... 00:00:30 Biological vs. chronological age and the immune system ... 00:04:55 Impact of trauma and stress on aging ... 00:11:51 Overcoming prognosis: lifestyle and scientific interventions ... 00:18:02 Diet, tracking, and removing triggers ... 00:22:21 The overlooked importance of thyroid health ... 00:32:23 Dangers of overdoing fasting and hormesis ... 00:40:21 Autophagy basics and the cellular cleanup crew ... 00:44:06 Spermidine's role, sourcing, and supplement quality ... 01:10:19 Optimizing longevity habits and daily routines ... 01:29:44 Our Amazing Sponsors: Tro Zzz by Troscriptions – A fast-acting sleep troche that dissolves in your cheek and combines melatonin with compounds like honokiol, adenosine, cordycepin, CBD, CBN, and 5-HTP to support deep, restorative sleep when travel, stress, or late workouts throw things off. Head to troscriptions.com and use code NAT10 for 10% off your first order. BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20. Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to http://www.profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#419: A Mind-Blowing Mitochondria Episode— Mito Transplant, Rare Diseases & Biomarkers With Dr. Natalie Yivgi-Ohana
Today, I'm joined by the extraordinary Dr. Natalie Yivgi-Ohana, a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age. Episode Timestamps: Welcome to the Longevity Podcast and today's focus on mitochondria ... 00:00:00 Maternal inheritance and critical functions of mitochondria ... 00:05:56 Mitochondria as energy producers and hormone regulators ... 00:07:03 Aha moments: mitochondria control life, death, and disease ... 00:08:55 Endosymbiotic theory: how mitochondria originated ... 00:10:19 Chronic disease, aging, and the connection to mitochondria ... 00:16:10 Substrate fuels: carbs, fats, and importance of metabolic flexibility ... 00:20:18 Mitochondria's control over immune system and signaling ... 00:26:39 Mitochondrial transfer: how cells share organelle "powerhouses" ... 00:32:42 Groundbreaking therapy: transplanting mitochondria for rare diseases ... 00:36:40 Expanding mitochondrial therapies to age-related diseases ... 00:42:57 Aging in women: hormones, mitochondria, and inflection points ... 00:51:00 Stem cell exhaustion and cellular renewal ... 00:52:24 Biomarkers: ways to measure mitochondrial health ... 01:03:11 Supplements, lifestyle, and emotional health for mitochondria ... 01:15:47 Medication choices and minimizing mitochondrial toxicity ... 01:24:04 Our Amazing Sponsors: O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off. Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum
Today, I'm joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health. If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout. Episode Timestamps: Welcome and introduction to Longevity Podcast ... 00:00:00 Challenging beliefs about aging and cellular health ... 00:12:00 Deep dive into NAD+ biochemistry and cellular function ... 00:13:08 NAD+/NADH balance: Why both matter ... 00:15:24 Why NAD+ declines: Not just aging, but increased degradation ...00:18:26 The role of CD38 and NMNT enzymes in NAD metabolism ... 00:20:14 Controversy and confusion: NAD+ precursors (NR, NMN) and IVs ... 00:22:28 Methylation's hidden importance in NAD supplementation ... 00:30:55 Supplementing 1-MNA: Understanding dosages and applications ... 00:50:54 Assessing NAD+ status: Biomarkers and limitations of testing ... 00:53:01 Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation ... 00:57:14 Ketones: Beyond performance, supporting cellular energy and longevity ... 01:06:03 Future of NAD science: Anticipating new insights and risks ... 01:11:45 Confidence and humility: Advice for navigating the longevity field ... 01:18:52 Our Amazing Sponsors: Qualia Creatine+ by Qualia Life – A clinically formulated blend of two highly bioavailable forms of creatine plus magnesium and electrolytes to support lean muscle, cellular energy, and brain health—especially for women over 40 who naturally produce less with age. Go to qualialife.com/nathalie and use code NATHALIE to save up to 50%, plus an additional 15% off. Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off. Gut Essentials Bundle by Just Thrive Health – This powerhouse duo pairs the only probiotic clinically proven to arrive 100% alive in your gut with science-backed Digestive Bitters to reduce bloat, curb cravings, and support better energy fast. Take the Just Thrive Feel Better Challenge and save 20% at justthrivehealth.com/NAT20 with code NAT20. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
#417: Depression and Weight Gain In Kids & Adults | A Long Term Post-COVID Problem & How To Reverse It With Dr. Cynthia Keller
Today, I'm joined by the innovative Dr. Cynthia Keller, a pediatrician whose passion for integrative and functional medicine has reshaped how we understand post-COVID health challenges. Dr. Keller opens up about her journey from conventional medicine to designing unique solutions for children and families, revealing how her care, presence, and determination to "solve the unsolvable" led to breakthroughs in treating mood changes, weight gain, and energy loss after COVID. Special Offer: If you go to alchemicmedicinals.com and use code NatRocks at checkout, you'll get a whopping 50% off of the Tryptophan Re-Genesis™ Powder while supplies last! (Capsules not included). Episode Timestamps: Introduction and host's mission ... 00:00:00 From standard care to integrative pediatrics ... 00:05:05 Patterns in pediatric development and disease ... 00:09:19 Gut health, emotional factors, and parenting ... 00:10:44 Clinic model and multidisciplinary care ... 00:15:04 Post-COVID nutrient depletion: clinical discoveries ... 00:18:03 Key depleted cofactors and rapid recovery ... 00:19:31 COVID's ongoing impact on gut and microbiome ... 00:24:39 Grassroots collaboration and evolving strategies ... 00:26:28 Clinical patterns: mood, weight, thirst ... 00:36:02 Family-wide interventions and quick results ... 00:46:24 Symptoms-based approach, minimal testing ... 00:52:07 Supplementation protocol and cautions ... 00:57:14 Product development and access ... 01:08:22 Infant microbiome and generational shifts ... 01:10:28 Pediatricians: importance of listening and presence ... 01:20:09 Love and connection in clinical care ... 01:21:01 Modern dysregulation: loss of boredom ... 01:22:28 Our Amazing Sponsors: Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off. Youth Daily by Young Goose — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours at younggoose.com and use code Nat10 for first orders or this link and code 5NAT for returning customers. Mitopure Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to timeline.com/nat20 for 20% off Mitopure Gummies. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode