Iron Culture presented by MASS

In this episode of Iron Culture, Eric Trexler interviews Dr. Marc Lewis, the director of Applied Sports Science for the Houston Texans. They discuss the role of sports scientists in maximizing athlete performance through data collection, management, and analysis. Marc shares insights on the day-to-day responsibilities of a sports scientist, the importance of understanding athlete load and stress, and the evolution of sports science in the NFL. They also explore the future of sports science careers and provide advice for aspiring sports scientists. Need some lifting gear? Use our discount code (MRR10) over at www.elitefts.com Check out Dr. Lewis' new book here: https://www.sportsciencenetwork.com/handbook Keep up-to-date with Dr. Lewis and his projects: https://drmarclewis.com/ Instagram: @marctlewis Twitter/X: @marctlewis Chapters 00:00 Introduction to Sports Science in Football 01:47 What Does a Sports Scientist Do? 7:26 From Data to Decisions 11:00 Navigating the Data Overload 23:13 Applied Data Versus Peer-Reviewed Evidence 27:20 Applying Sports Science Insights to Strength Coaching 34:46 The Reality of Overtraining in Elite Sport Versus General Fitness 45:17 The Extremes of Human Performance 51:01 Unique Needs of Elite Athletes 56:45 The Current State (and Future) of Sports Science in America 1:09:46 Building a Career in Sports Science

In this episode of Iron Culture, hosts Eric Trexler and Eric Helms discuss recent developments in college football and powerlifting, in addition to introducing their partnership with Elite FTS. The conversation shifts to a Q&A session where they address various topics, including collagen supplementation, creatine dosage, and the relationship between muscular endurance and strength. They also provide practical tips for reducing food focus during dieting and discuss the impact of hypertrophy on athletic performance. Need some lifting gear? Use our discount code (MRR10) over at www.elitefts.com Time stamps 00:00 Introduction (College Football & Powerlifting News) 04:25 Partnership with Elite FTS and Personal Experiences 11:50 Collagen Supplementation: Debates and Research Overview 35:37 Power Development: Training Volumes and Frequencies 49:00 Creatine: Dosage, Urination Frequency, and Cognitive Effects 1:03:18 Muscular Endurance: Training Insights 01:08:34 Hypertrophy and Athletic Performance 1:19:00 Creatine During Peak Week 1:19:58 Dieting Strategies and Food Focus

In this episode of Iron Culture, hosts Eric Trexler and Eric Helms discuss various topics including the ongoing debate about the relationship between muscle growth and strength gains. They discuss brand new findings from the largest and longest-running study on resistance training, explore the implications of "apparent" sex differences in strength gains, and emphasize the need for nuanced statistical analysis in understanding the factors that contribute to strength gains and observed sex differences. Want to read a thorough analysis of the article we discussed in this episode (and many more)? Support the show by joining the MASS Community at massresearchreview.com Chapters 00:00 Intro 09:10 The Debate on Muscle Size and Strength 12:30 New Research on Muscle Strength and Size 20:45 Exploring Sex Differences in Muscle Training 26:40 The Hierarchy of Evidence in Research 32:00 Relationships Between Strength And Muscle Size 36:40 Lifting For Sport: History And Changing Cultural Norms 39:00 Back To The Study Results (Understanding Sex Differences in Strength Gains) 42:15 Nuances of Statistical Analysis: Relationships Between Strength And Muscle Size 54:10 Aside About Collegiate Sports In USA 56:50 Causal Discovery Analysis in Strength Research 1:08:00 Summary and Conclusions: The Role of Muscle Growth in Strength Gains 1:21:45 Listener Question: Sample Sizes in Exercise Science 1:27:10 Outro

In this episode of Iron Culture, hosts Eric Helms and Michael Zourdos engage with Dr. Zac Robinson to discuss his dissertation research on the effects of resistance training volume on muscle adaptations. The conversation delves into the complexities of individual responses to training, the importance of research design, and the implications of findings for coaching practices. They emphasize the need for caution in interpreting data and the evolving nature of sports science, highlighting the significance of collaboration and flexibility in training approaches. Chapters 00:00 Introduction and Guest Introduction 06:25 The PhD Journey and Team Dynamics 11:32 Dissertation Overview and Research Focus 18:43 Research Methodology and Individual Variability 26:50 Understanding Individual Response Variation in Training 32:09 Study Design: Isolating Variables in Training Responses 37:33 The Importance of Replication in Research 42:40 Findings 53:41 Limitations and Implications of the Study 01:00:17 Genetics and Individual Response Variability 01:02:59 The Dose-Response Relationship in Training 01:06:25 Shifting Perspectives on Training Individualization 01:11:00 The Role of Sports Science in Coaching 01:19:51 Future Directions in Resistance Training Research

In this episode, Drs Trexler and Helms discuss various topics including updates on Eric's surgery, the valuable (but very modest) effects of protein intake on muscle gains, incontinence after contest prep, the relationship between sleep quality and nutrient timing, the recent ban on smelling salts in the NFL, and more. Time stamps: 00:00 Introduction 01:11 Preview of next week's episode (non-responders, hyper-responders, etc) 07:01 Trex's surgery update 12:11 Discussion on Protein Meta-Analyses and Research Updates (how much does protein intake actually matter for gains?) 33:10 Why meta-analyses differ from RCTs in terms of "expiration dates" 44:15 The Impact of Training vs. Nutrition (for muscle growth) 51:41 Q&A: Supplementation for Lifters (and Specifically Vegans Who Lift) 55:49 Incontinence, Increased Urine Output, and Contest Prep 59:16 Chrono Nutrition and Sleep Quality 01:11:28 The Role of Smelling Salts in Sports Performance (and Football)

In this episode of Iron Culture, Helms and Trex have a lengthy discussion about the ECA stack and yohimbine. The history, the mechanisms, the regulatory changes, the practical applications – you name it, they cover it. Don't miss this episode if you have an interest in fat loss, stimulants, or dietary supplementation in general. Also, be sure to check out the newest issue of the MASS Research Review! Learn more at massresearchreview.com Time stamps 0:00 Intro 4:18 New issue of the MASS Research Review 10:42 Helms contest prep update 13:15 The history of the ECA stack and supplement regulation 30:07 Ephedra vs Ephedrine 35:31 Why people took ephedrine / ECA stack 36:30 Trends in PED use over time 45:00 Research on the ECA stack 50:58 Banning lifters for stimulant use 53:15 Effects of ephedrine + caffeine on metabolism and fat loss 1:02:44 What does aspirin really add to the ECA stack? 1:13:00 Do NSAIDs blunt hypertrophy? 1:21:25 How yohimbine works (and yohimbe vs yohimbine distinction) 1:31:10 Regulatory status of yohimbine 1:32:58 Practical applications

Back when Trex was a 14 year old, his wrestling coach noticed his passion for training and nutrition. This coach took Trex under his wing, and they started absorbing and applying as much information as they could. Their source material, almost exclusively, was the content produced by Dr. Jim Stoppani – primarily from magazine articles, but also from the totally novel medium of online video content. Jim was a jacked PhD with tons of "in the trenches" experience - back in 2005 that was a very rare combination, and there's no question that people like Jim led the way for the next generation of "bodybuilding academics" like Helms and Trex. Jim has made a huge mark on the fitness industry. Perhaps his most impressive feat is maintaining his impact and relevance as the industry has fundamentally transformed itself multiple times. Jim was the face of some of the biggest muscle magazines (in their prime), one of the most recognizable content creators when bodybuilding dot com was THE place for online fitness, and way ahead of the curve when it comes to building your own platform and leveraging mobile fitness applications. In this episode of Iron Culture, the Erics have a great chat with Dr. Stoppani about how the industry (and science communication more broadly) has evolved over the last 25-30 years. To learn more about Jim and support his work, check out his social media channels and his website https://www.jimstoppani.com/ Time stamps 0:00 Intro 3:22 Jim's education 14:18 Jim's transition to the muscle magazine industry 30:44 Jim's bodybuilding dot com days 44:52 Fitness content creation in the age of social media: the good, the bad, and the ugly

Join hosts Eric Trexler and Eric Helms as they explore the potential "replication crisis" in exercise science, drawing parallels to the well-documented crisis in psychology. In this episode, they delve into the challenges of replicating research findings, the perils of placing too much confidence in singular studies, the importance of cautious interpretation of new studies, and the value of meta-analyses in understanding true effect sizes. Whether you're a seasoned lifter or new to the world of evidence-based practice, this conversation offers valuable insights into making informed decisions about your training. Time stamps: 00:00 – Introduction (and Helms' travel updates) 17:29 - Replication Crisis in Psychology: Discussion on the replication crisis observed in psychology and its implications. 32:45 – What is "replication" 44:36 – Results of "reproducibility project" in exercise science 1:00:04 – Why are replication rates so low in exercise science? 1:27:24 – What does this mean for "evidence-based fitness" and application of exercise science? Relevant links: www.massresearchreview.com https://pubmed.ncbi.nlm.nih.gov/26315443/ https://pubmed.ncbi.nlm.nih.gov/40522610/

In this episode of Iron Culture, Dr. Eric Trexler and Dr. Lauren Colenso-Semple discuss science related to attractiveness, coolness, and personality type. They explore scientific studies on the factors associated with perceived attractiveness and "coolness," discussing body fat percentages and societal perceptions. The conversation shifts to how personality traits appear to predict workout preferences and engagement in fitness, then they debate the importance of matching exercise to individual characteristics. Time stamps: 00:00 Introduction to Iron Culture and Guests 5:57 The Science of (Male) Attractiveness 10:39 Evolutionary Underpinnings of Male Attractiveness 13:53 Distorted Perceptions of Attractiveness (In the Fitness World) 20:10 The Irony of Pursuing Attractiveness 22:22 Body-Fat and Optimized Health 24:18 Surprising Article Feedback 28:50 Unrealistic Body Standards and Gender Perceptions 32:49 Achieving the Outcome Versus Doing Hard Things 35:07 Attractiveness is More Than Body Shape/Size 37:48 The Science of Being Cool 47:19 Matching Exercise To Personality Types References: Xia F, Sauciuvenaite J, Bissland R, Hambly C, Starr-Vaanholt L, Faries MD, et al. The relationship between body fatness and physical attractiveness in males. Personality and Individual Differences. 2025 Sep 1;243:113240. de Jager S, Coetzee N, Coetzee V. Facial Adiposity, Attractiveness, and Health: A Review. Front Psychol. 2018 Dec 21;9:2562. Brierley ME, Brooks KR, Mond J, Stevenson RJ, Stephen ID. The Body and the Beautiful: Health, Attractiveness and Body Composition in Men's and Women's Bodies. PLoS One. 2016;11(6):e0156722. Sorokowski P, Kościński K, Sorokowska A, Huanca T. Preference for Women's Body Mass and Waist-to-Hip Ratio in Tsimane' Men of the Bolivian Amazon: Biological and Cultural Determinants. PLoS One. 2014 Aug 22;9(8):e105468. Tovée MJ, Cornelissen PL. Female and male perceptions of female physical attractiveness in front-view and profile. Br J Psychol. 2001 May;92(Pt 2):391–402. Jayedi A, Khan TA, Aune D, Emadi A, Shab-Bidar S. Body fat and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Int J Obes (Lond). 2022 Sep;46(9):1573–81. Hu J, Chen X, Yang J, Giovannucci E, Lee DH, Luo W, et al. Association between fat mass and mortality: analysis of Mendelian randomization and lifestyle modification. Metabolism. 2022 Nov;136:155307. Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, Sørensen TIA, Olsen J. Subfecundity in overweight and obese couples. Hum Reprod. 2007 Jun;22(6):1634–7. Wei S, Schmidt MD, Dwyer T, Norman RJ, Venn AJ. Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin. Obesity (Silver Spring). 2009 May;17(5):1070–6. Liu Y, Hu X, Xiong M, Li J, Jiang X, Wan Y, et al. Association of BMI with erectile dysfunction: A cross-sectional study of men from an andrology clinic. Front Endocrinol (Lausanne). 2023;14:1135024. https://psycnet.apa.org/doiLanding?doi=10.1037%2Fxge0001799 https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1587472/full

In this episode of Iron Culture, Eric Helms interviews Dr. Stian Larsen, who shares his journey from powerlifting to becoming a researcher in exercise science. They discuss the intricacies of biomechanics, the importance of understanding squat techniques, and the latest research findings on muscle hypertrophy and resistance profiles. Stian emphasizes the need for practical applications in training and the significance of collaboration in research. The conversation also touches on future research directions and the role of education in advancing the field of strength training. Time stamps 0:00 Introduction 4:33 Stian's Journey in Powerlifting and Coaching 16:00 Biomechanics and the Sticking Point in Squats 23:56 Understanding Muscle Forces and Training Strategies 33:04 Transitioning to Hypertrophy Research 35:43 Research on Muscle Length and Hypertrophy 48:58 Practical Applications of Research Findings 50:02 Biceps Research Findings and Surprises 1:03:28 Practical Applications of Research Findings 1:04:53 Quadriceps Hypertrophy Study Results 1:22:27 Lateral Raises and Resistance Profiles

In this episode of Iron Culture, the Erics provide some updates, corrections, and clarifications related to their recent episode exploring the science of microplastics. After that they take a brief moment to celebrate the 100th issue of the MASS Research Review, then answer listener questions on topics including: tasty meat alternatives, programming supersets, scaling dietary variables for very small/short individuals, the pros & cons of "extended release" caffeine formulations, the utility & shortcomings of BMI as a health metric, and more. MASS is celebrating its 100th issue, but it's never to late to join in on the fun! Learn more at massresearchreview.com Also, don't miss Iron Culture's sister podcast, ⁨@fpfpodcast⁩ hosted by MASS's very own Eric Trexler and Dr. Lauren Colenso-Semple Time stamps (coming soon): 0:00 Intro 0:58 Revisiting microplastics (updates, corrections, and clarifications) 25:08 MASS celebrates 100th issue 34:00 Well-wishes for bodybuilding legend Ronnie Coleman 41:37 Tasty meat alternatives 47:12 Programming supersets 49:23 Scaling dietary variables for very small/short individuals 57:10 The utility & shortcomings of BMI as a health metric 1:05:03 Individual response variation to training 1:16:12 The pros & cons of "extended release" caffeine formulations

In this episode of Iron Culture, Dr. Eric Helms talks about his forthcoming article in the MASS Research Review covering the purported harms of high-protein diets. This isn't your typical oversimplified dunk-fest that readily dismisses concerns about high-protein diets. Instead, Helms reviews a thorough paper that reviews common concerns in detail and assessed their plausibility in an objective manner. The claims include: Claim 1 – protein reduces lifespan Claim 2 – protein makes bones weaker Claim 3 – protein harms kidneys Claim 4 – protein causes diabetes After that, Dr. Eric Trexler discusses a recent Instagram thread that pulled him into arguments against his will. The post was about his recent article on ketogenic diets and seed oils – two topics that are always bound to attract some controversy and heated debate. This conversation discusses the strengths and limitations of different types of scientific research and also touches on bias, objectivity, and the process of seeking the truth with an open mind. Time stamps: 0:00 Intro 3:00 Helms' new article about the purported harms of high-protein diets 19:25 Claim 1 – protein reduces lifespan 27:48 Claim 2 – protein makes bones weaker 43:38 Claim 3 – protein harms kidneys 50:53 Claim 4 – protein causes diabetes 57:22 Trex's social media beefs – keto and seed oils 1:03:40 Types of observational studies 1:08:35 Seeking truth versus defending biases 1:17:32 Limitations versus fatal flaws 1:24:19 Limitations of RCTs (randomized controlled trials) 1:32:23 Wrapping up

In this episode, the hosts discuss various aspects of bodybuilding prep, including caloric intake, metabolic adaptation, and the impact of extreme dieting. They explore historical studies that provide insights into these phenomena and discuss practical strategies for weight loss. The conversation transitions to powerlifting, specifically the recent IPF Worlds, highlighting the competitive dynamics and standout performances in the event. In this conversation, Eric Helms highlights impressive performances and battles in various weight classes. He emphasizes the growth of the sport and the challenges faced by lifters, particularly in extreme conditions. The subsequent Q&A covers the balance between powerlifting and bodybuilding, exercise order for hypertrophy, and the relationship between energy balance and recovery. Additionally, the practicality and effectiveness of using weighted vests for exercise are examined, providing insights into their potential benefits and drawbacks. Time stamps: 00:00 Introduction and Helms' Updates on Bodybuilding Prep 01:50 Caloric Intake and Metabolic Adaptation 05:35 Extreme Cases of Metabolic Adaptation: Insights from Historical Studies 25:26 IPF Worlds Recap 44:44 Programming for Powerlifting and Bodybuilding (Simultaneously) 48:26 Exercise Order and Hypertrophy 01:00:23 Energy Balance and Recovery 01:05:44 The Pros and Cons of Weighted Vests

In this episode of Iron Culture, the Erics begin by discussing Helms' prep updates and the standout performances from the recent powerlifting World Champions. The conversation also touches on body composition and attractiveness, highlighting the misconceptions in the fitness industry regarding ideal body fat levels. After that they take a deep dive into the strategies of cutting weight in various sports, comparing the approaches of powerlifting, bodybuilding, and combat sports. Finally, they explore the differences in weight cutting techniques across different sports, emphasizing the importance of planning and strategy for optimal performance. Time stamps: 00:00 Helms Prep Update and World Powerlifting Highlights 15:07 Body Composition, Attractiveness, Evolution, and the Fitness Industry 31:16 Trexler's Take On Comparing Weight Cuts in Different Sports (Powerlifting, Bodybuilding, Combat Sports) 40:32 Helms' Take On Comparing Weight Cuts in Different Sports (Powerlifting, Bodybuilding, Combat Sports) 57:11 Electrolyte Management and Hydration Techniques 1:03:05 Final Thoughts on Weight Management and Performance

In this episode of the Iron Culture Podcast, the Erics discuss various topics including updates on Helms' contest prep vlog, a preview of the upcoming Powerlifting World Championships, misconceptions surrounding TRT, the effects of cold exposure, and the concept of lean mass hyper responders. They also discuss the importance of (and misconceptions surrounding) women's health research, and engage in a Q&A session addressing questions about energy expenditure, body composition, and more. Time stamps: 00:00 Introduction and Updates 02:59 Powerlifting World Championships Preview 07:55 New MASS issue; TRT misconceptions 16:50 Cold Exposure and Its Misconceptions 18:00 Lean Mass Hyper Responders (and resulting chaos) 31:20 Women's Health and Fitness Research 46:24 Understanding Training Status in Research 52:52 Core Strengthening and building general athleticism 59:03 Debunking Myths Around Posture and Anterior Pelvic Tilt 01:01:50 Evaluating BIA and BIS for Body Composition 01:10:48 Reconciling Energy Expenditure Models in Active Populations

What's the deal with microplastics? Where do they come from? Are they in our bodies? If so, are they harmful? Also, what's the deal with microwaving Tupperware and other plastic containers? This episode is all about plastics - what we know, what we don't know, and what you can do about it. Key reference: https://pmc.ncbi.nlm.nih.gov/articles/PMC11800385/ Time stamps: 0:00 Intro 7:20 What are microplastics and where to they come from? 16:40 How much microplastic is in our bodies? Does it seem to be a problem? 32:05 What can you do about microplastics? 41:50 What can you do about Tupperware and other food storage options? 1:06:51 Related Q&A 1:20:48 Wrapping up

In this episode of Iron Culture presented by MASS, Dr. Eric Helms and Dr. Eric Trexler dive into a wide-ranging discussion covering updates on the long-awaited 3rd edition of the Muscle & Strength Pyramids, the writing process at MASS, and their recent frustrations with pseudoscientific claims in fitness and health. They dissect recent content related to eccentric training, ketogenic diets, LDL cholesterol myths, and the fine line between critical thinking and cynicism. Plus, they tackle rapid-fire audience questions on deloading, protein intake, training at short vs. long muscle lengths, and more. Timestamps 0:00 Intro 1:43 Muscle and Strength Pyramids Update 7:00 Why the Erics are extra snippy (about popular pseudoscience) in the upcoming issue of MASS 12:00 Keto diets and LDL (new research) 20:20 Why pseudoscience gains popularity 24:00 Cynicism vs. Skepticism 32:09 Paradigm shifts 37:02 Should I deload every 4 weeks? 46:02 Shortened vs. lengthened muscle training 50:37 High protein diets and kidney health question 53:21 Muscle imbalances after injury rehab 61:29 Why do we speak about the thermic effect of feeding so imprecisely? Why not manipulate it with high degree of specificity? 74:17 Hypertrophy rep ranges 74:56 Exercise science study design versus real-world questions 84:54 What's up with microplastics? 93:24 Wrapping up

In this episode of Iron Culture, hosts Eric Trexler and Eric Helms discuss a variety of topics related to bodybuilding, nutrition, and fitness. First they share updates on Front Page Fitness and discuss some soon-to-be-released articles from the Mass Research Review, with topics including the implications of cold exposure, how much testosterone actually impacts muscle mass, seed oils, the effects of ketogenic diets on blood lipids, and eccentric training on muscle growth. The conversation also touches on the effects of alcohol consumption, navigating excess skin after weight loss, fat loading, sodium intake, meditation to acutely impact lifting performance, the effects of creatine supplementation, circuit training, and much more. Time stamps: 00:00 - Opening and introductions 03:29 - Mass Research Review June issue preview - cold exposure vs heat, testosterone/TRT, dietary fat & seed oils 10:25 - Lean mass hyperresponders critique - "most egregiously misnamed term in health and physiology" 14:06 - Helms' articles: eccentric training defense and time-restricted feeding for hypertrophy 14:26 - Eccentric training controversy - debunking claims that eccentrics are useless or harmful 19:03 - Philosophy of science in fitness - how to evaluate competing training theories and models 22:20 - Formal education vs self-education - value of academic guardrails in exercise science 29:08 - Excess skin after weight loss - factors affecting skin elasticity and examples 38:20 - "Muscle maturity" phenomenon - skin thickness changes with age in bodybuilders 41:19 - Fat loading for bodybuilding - critical analysis of peak week strategies 48:51 - Deadlift re-bracing strategy - reset between reps vs continuous reps 52:27 - High sodium intake in athletes - 7g/day vs health recommendations 58:30 - Creatine and body odor - addressing unusual supplement side effect claims 61:01 - Alcohol consumption and fitness - 2-3 vodka drinks nightly impact on muscle growth 69:08 - Meditation and training performance - mental fatigue vs relaxation before lifting 74:59 - Diet quality vs calories - what drives weight gain in real-world scenarios 78:28 - Circuit training benefits - supersets and time-efficient programming 82:47 - Creatine effectiveness long-term - one-time investment vs compounding benefits 86:24 - Wrapping up

In this episode of Iron Culture, hosts Eric Helms and Michael Zourdos reconnect and reflect on their experiences at the 2025 Sports Nutrition Association annual conference. Joined by guests Dr. Nick Washmuth and Kaylee Chism, they delve into the concept of daily 1RM training, discussing its origins, methodology, and findings from a recent study involving participants who maxed out daily. Insights from the participants reveal varied results and experiences, highlighting the mental and physical challenges of such a training protocol. The conversation also explores the importance of dosage, frequency, intensity, and the need for more empirical data to better understand the effectiveness of daily 1RM training. The episode covers various training protocols, particularly focusing on volume training and its effects on strength gains. The hosts and guests discuss personal experiences with different lifting protocols, the importance of balancing other lifts during intense training, and the recommendations for those interested in 1RM training. Additionally, they explore the intriguing concept of swearing as a performance enhancer, examining its psychological effects and potential benefits in athletic performance. Time stamps: Coming soon! Reminder:Don't forget to check out our sister podcast, Front Page Fitness, hosted by Drs. Lauren Colenso-Semple and Eric Trexler!youtube.com/@fpfpodcast

In this episode of Iron Culture, hosts Eric Helms and Michael Zourdos reconnect and reflect on their experiences at the 2025 Sports Nutrition Association annual conference. Joined by guests Dr. Nick Washmuth and Kaylee Chism, they delve into the concept of daily 1RM training, discussing its origins, methodology, and findings from a recent study involving participants who maxed out daily. Insights from the participants reveal varied results and experiences, highlighting the mental and physical challenges of such a training protocol. The conversation also explores the importance of dosage, frequency, intensity, and the need for more empirical data to better understand the effectiveness of daily 1RM training. The episode covers various training protocols, particularly focusing on volume training and its effects on strength gains. The hosts and guests discuss personal experiences with different lifting protocols, the importance of balancing other lifts during intense training, and the recommendations for those interested in 1RM training. Additionally, they explore the intriguing concept of swearing as a performance enhancer, examining its psychological effects and potential benefits in athletic performance. Reminder:Don't forget to check out our sister podcast, Front Page Fitness, hosted by Drs. Lauren Colenso-Semple and Eric Trexler! youtube.com/@fpfpodcast Time stamps: 00:00 Intro 04:00 Daily 1RM Training: Origins and Insights 12:00 Introducing the New Study on Daily One RM Training 33:30 Auto-Regulation in Training 39:30 "Dosage": Frequency, Intensity, and Proximity to Failure 44:26 Specificity vs. Generalization in Training 54:00 Volume Considerations 01:11:00 Recommendations for 1RM Training Protocols 01:16:30 Squat Mechanics and Individual Variability 01:22:30 Effects of Swearing in Performance 01:39:40 Wrapping up

This is a very special episode of Iron Culture because it's the WORLD PREMIERE of "Front Page Fitness," a new podcast hosted by Drs Eric Trexler and Lauren Colenso-Semple. If you're part of the Iron Cult, these folks are no strangers - both have been on Iron Culture numerous times, and both are co-authors of the MASS Research Review. In Front Page Fitness, Eric & Lauren discuss the hottest health and fitness topics that are causing controversy, generating buzz, or dominating headlines. In other words, it's your weekly health and fitness newspaper, delivered in podcast form. Be sure to subscribe to their new podcast so you can continue enjoying their weekly episodes: https://www.youtube.com/@fpfpodcast https://creators.spotify.com/pod/profile/frontpagefitness/ Time stamps: 00:00 Introducing Front Page Fitness 01:42 Why you should care about Lauren has to say 08:54 An insight into Trexler's life 15:19 Alcohol, health, and Lauren's wine certification O'Keefe Alcohol and cardiovascular health: the razor-sharp double-edged sword https://pubmed.ncbi.nlm.nih.gov/17825708/ Biddinger 2022 Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease https://pubmed.ncbi.nlm.nih.gov/35333364/ 31:25 The updated consensus and public health messaging 44:15 The health optimisation phase and health promoting habits 49:43 Florida man and cholesterol Marmagkiolis 2025 Yellowish Nodules on a Man Consuming a Carnivore Diet https://pubmed.ncbi.nlm.nih.gov/39841435/ 59:45 Trexler's experience on a ketogenic diet and the Front Page Fitness Cheez Whiz challenge

The MASS Research Review started in 2017 and has provided cutting-edge evidence-based fitness content - every single month - ever since. Nearly 1500 articles and videos later, the MASS Crew is all in the same physical location for the first time in history. To commemorate the occasion, the MASS Crew sat down for a roundtable discussion about interpreting, communicating, and applying science in a nuanced manner. Listen along to gain some insights related to strengths, limitations, caveats, and tips for applying the information you gather from content creators and published research. Time stamps: 0:00 Introduction to a history making episode and a Front Page Fitness sneak peek 2:58 Florida man and a new cholesterol excretion mechanism? Marmagkiolis 2025 Yellowish Nodules on a Man Consuming a Carnivore Diet https://pubmed.ncbi.nlm.nih.gov/39841435/ 13:17 A discussion on Zourdos' physical appearance and getting into effective science communication – periodisation chat 27:27 Myth busting claims and their citations Rossow 2013 Natural bodybuilding competition preparation and recovery: a 12-month case study https://pubmed.ncbi.nlm.nih.gov/23412685/ 43:01 Why its normal for Science to flip-flop and meta-analytic and multi-site methods Iron Culture Ep 322- The Science of "Junk Volume" (ft. Jake Remmert) https://www.youtube.com/watch?v=8e4Jn9GJ8WU Refalo 2025 Effect of Dietary Protein on Fat-Free Mass in Energy Restricted, Resistance-Trained Individuals: An Updated Systematic Review With Meta-Regression https://journals.lww.com/nsca-scj/fulltext/9900/effect_of_dietary_protein_on_fat_free_mass_in.179.aspx 1:00:22 Science communication gaps in the field of sport/exercise and nutrition science (and some tangents 1:08:51 Closing out the first and last full meet-up of the MASS crew

In this episode of Iron Culture, host Eric Trexler and guest Jake Remmert discuss a new meta regression paper focusing on per session set volume and its impact on hypertrophy and strength. They explore the nuances of per session training volume, the implications of the findings, and address common misconceptions in the fitness community. The conversation emphasizes the importance of understanding the data and its limitations while providing practical applications for training. Time Stamps: 0:00 Housekeeping and Introducing Jake Remmert and his journey MASS Research Review ⁠https://massresearchreview.com/⁠ Sports Nutrition Association Annual Conference 2025 ⁠https://sportsnutritionassociation.com/sna-annual-2025-conference/⁠ 16:00 New meta-analysis on per-session volume: an insight into the methods Pelland 2024 The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain ⁠https://sportrxiv.org/index.php/server/preprint/view/460/version/587⁠ Robinson 2024 Exploring the Dose–Response Relationship Between Estimated Resistance Training Proximity to Failure, Strength Gain, and Muscle Hypertrophy: A Series of Meta-Regressions ⁠https://pubmed.ncbi.nlm.nih.gov/38970765/⁠ Remmert 2025 Is There Too Much of a Good Thing? ⁠https://sportrxiv.org/index.php/server/preprint/view/537/version/689⁠ 29:45 Diving into the findings related to hypertrophy 44:44 Issues with conducting a study directly assessing per session set volume 47:02 Strength results 58:07 The practical applications: how the results of these meta-regressions influenced Jake's training and coaching 01:15:21 Addressing the feedback on the paper Refalo 2024 Similar muscle hypertrophy following eight weeks of resistance training to momentary muscular failure or with repetitions-in-reserve in resistance-trained individuals ⁠https://pubmed.ncbi.nlm.nih.gov/38393985/⁠ 01:24:17 Jake's final thoughts on the paper and a quick history of meta-analyses Where to find Jake: Instagram: @jake.remmert_coach ⁠https://www.instagram.com/jake.remmert_coach/⁠ Website: ⁠https://www.jakeremmert.com/⁠

In this episode of Iron Culture, hosts Eric Trexler and Eric Helms discuss various topics related to fitness, nutrition, and hydration. They delve into the importance of hydration, the potential for overhydration, and the effects of vitamin C and gelatin on muscle recovery. The conversation also covers the debate between eccentric and concentric training for muscle growth, as well as the relationship between cardio and strength training. Throughout the episode, the hosts emphasize the need for evidence-based practices in fitness and nutrition, while also addressing common misconceptions in the fitness community. To attend the upcoming SNA conference electronically and see the entire MASS team's presentations, you can find tickets here: https://sportsnutritionassociation.com/sna-annual-2025-conference/ To submit a question for us to answer on the show, head over to https://massresearchreview.com/ironculture/ Time stamps: 00:00 Intro 07:17 Afterhours question: over- and de-hydration Peacock 2011 Initial hydration status, fluid balance, and psychological affect during recreational exercise in adults https://pubmed.ncbi.nlm.nih.gov/21574099/ Stover 2006 Urine specific gravity in exercisers prior to physical training https://pubmed.ncbi.nlm.nih.gov/16770361/ Kouri 1995 Fat-free mass index in users and nonusers of anabolic-androgenic steroids https://pubmed.ncbi.nlm.nih.gov/7496846/ 13:24 Hydration status, training adaptations, and strategies for athletic events 26:08 Gut cut and water manipulation strategies for powerlifting and lifestyle factors which could be influencing hydration status 31:50 Urine colour (vitamin supplements and DIM) 35:47 Afterhours question: Are Vitamin C and Gelatin worth the hype? 42:17 Q&A 1: Can you consume too many micronutrients? 49:13 Q&A 2: Eccentric muscle actions for hypertrophy da Silva Comparison Between Eccentric vs. Concentric Muscle Actions On Hypertrophy: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/39652733/ 57:05 Q&A 3 Heart rate variability (HRV) and fatigue and recovery Robinson 2024 Exploring the Dose-Response Relationship Between Estimated Resistance Training Proximity to Failure, Strength Gain, and Muscle Hypertrophy: A Series of Meta-Regressions https://pubmed.ncbi.nlm.nih.gov/38970765/ 1:03:44 Tracking repetitions for unilateral exercises and cardio modalities for mitigating the interference effect Schumann 2022 Compatibility of Concurrent Aerobic and Strength Training for Skeletal Muscle Size and Function: An Updated Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/34757594/ 1:11:11 Closing out

In this episode of Iron Culture, hosts Eric Helms and Eric Trexler engage in a lively discussion with Dr. James Steele about the evolving landscape of sports science, particularly focusing on the critiques of periodization and the importance of scientific theory in exercise research. They explore the philosophical underpinnings of scientific inquiry, the challenges of conducting robust research, and the implications of recent studies on training effects. The conversation emphasizes the need for a more theory-driven approach in exercise science to enhance the validity and applicability of research findings. In this conversation, James Steele and Eric Helms discuss the intricacies of designing meaningful studies in hypertrophy research, emphasizing the importance of collaboration, causal inference, and the need for high-powered studies. They explore the challenges of resistance training research, the significance of theory corroboration, and the future directions for the field. The discussion highlights the necessity of passion and purpose in research, advocating for a focus on practical applications and the importance of understanding the underlying mechanisms of training effects. Time stamps: 0:00 Welcome to another episode of Iron Culture and some housekeeping https://massresearchreview.com/ https://sportsnutritionassociation.com/sna-annual-2025-conference/ 4:01 Welcoming Dr James Steele Iron Culture Ep 218 Science is Flawed, but Can be Fixed https://www.youtube.com/watch?v=D_NYCZpY3RA&t=1s Steele 2023 The Myth of Periodisation https://www.researchgate.net/publication/373512935_The_Myth_of_Periodisation Stone 2024 The Myth of the Myth? An Opinion https://journal.iusca.org/index.php/Journal/article/view/353 12:26 James' issues with periodisation 25:53 How different research areas work 36:03 The philosophy of science 44:47 James breaks down the (statistics of the) Gschneidner lengthened-partials study Gschneidner 2024 The effects of lengthened-partial range of motion resistance training of the limbs on arm and thigh muscle cross-sectional area https://sportrxiv.org/index.php/server/preprint/view/485 1:04:47 What are we actually trying to do in research and going over the results https://pubmed.ncbi.nlm.nih.gov/15947721/ Steele 2021 Long-Term Time-Course of Strength Adaptation to Minimal Dose Resistance Training Through Retrospective Longitudinal Growth Modeling https://pubmed.ncbi.nlm.nih.gov/35591809/ Hubal 2005 Variability in muscle size and strength gain after unilateral resistance training https://pubmed.ncbi.nlm.nih.gov/15947721/ Coleman 2022 Muscular Adaptations in Drop Set vs. Traditional Training: A meta-analysis https://journal.iusca.org/index.php/Journal/article/view/135 Sødal 2023 Effects of Drop Sets on Skeletal Muscle Hypertrophy: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/37523092/ 1:24:23 Linear log gains and the role of multi-site data collection Latella 2024 Using Powerlifting Athletes to Determine Strength Adaptations Across Ages in Males and Females: A Longitudinal Growth Modelling Approach https://pubmed.ncbi.nlm.nih.gov/38060089/ 01:38:51 Answering research questions, method reforms, and the reasons behind lifting 01:49:53 Final thoughts and a sneak peek into James' future work and where to find him ResearchGate https://www.researchgate.net/profile/James-Steele-14 Instagram @james.steeleii https://www.instagram.com/james.steeleii/?hl=en

In this episode of Iron Culture, Eric Helms and guests Conor Heffernan and Dr. Juan Carlos Casano delve into the intricate relationship between bodybuilding, performance-enhancing drugs, and athlete welfare. They discuss the historical context of bodybuilding, the cultural norms that have evolved over the years, and the alarming trends in mortality rates among bodybuilders. The conversation emphasizes the need for transparency in the sport and the impact of social media on perceptions of bodybuilding. The guests advocate for a more nuanced understanding of the issues surrounding drug use in bodybuilding and the importance of separating competitive practices from recreational bodybuilding for the sake of athlete safety. This conversation delves into the complexities of bodybuilding, focusing on the democratization of drug information, cultural issues, historical perspectives, and the impact of social media. The speakers discuss the need for regulation and safety measures in the sport, the motivations behind bodybuilding, and the legacy of past champions. They emphasize the importance of having open conversations about athlete safety and the future of bodybuilding, particularly in light of the increasing influence of social media and the need for a cultural shift within the sport. Time Stamps: 00:00 Welcome to another Iron Culture episode hosted by one Eric (Helms) https://sportsnutritionassociation.com/sna-annual-2025-conference/ 3:06 Welcoming back Dr Conor Heffernan and introducing Dr Juan Carlos Cassano and their new pre-print paper Cassano 2025 The Golden Paradox Mortality Trends Across Three Eras of Bodybuilding (1900-1990) https://sportrxiv.org/index.php/server/preprint/view/513 Iron Culture Ep. 203- Can Enhanced Bodybuilding Be Safer? (Ft. Dr. Guillermo Escalante) https://www.youtube.com/watch?v=7G_c1umHswE 10:58 The ideas behind the paper – shifting norms and starting discussion 26:32 The rise of natural bodybuilding and embedding safety in bodybuilding 37:33 The Overton window of physiques and PEDs for professional and recreational bodybuilders 41:56 How bodybuilding history relates to contemporary bodybuilding and PED dosages 54:42 Motivations for competing, pushing the limits, and building a legacy 1:10:25 Precedence of attempting to implement constraints into bodybuilding 1:21:13 Influence of social media, motivations for competing, and irresponsible use of PEDs 1:35:09 Final thoughts

In this episode of Iron Culture, hosts Eric Helms and Michael Zourdos engage in a deep discussion with Dr. Mike Ormsbee about the role of resistance training in fat oxidation and body composition. They explore how resistance training can be an effective tool for fat loss, the physiological mechanisms behind fat metabolism during exercise, and the importance of myokines and hormones in this process. The conversation challenges common perceptions about fat burning and emphasizes the need for a nuanced understanding of energy expenditure and body composition changes. In this conversation, Michael Zourdos and Mike Ormsbee delve into various aspects of nutrition and exercise science, emphasizing the importance of understanding the evolving nature of research. They discuss the significance of preclinical studies, the role of resistance training in fat loss, and the myth of spot reduction. The conversation also explores the interplay between glycogen and fat utilization, the implications of pre-sleep protein feeding, and the lessons learned from past research mistakes. The speakers highlight the need for collaboration in research and the ongoing exploration of nutritional timing and its effects on body composition and sleep quality. To stay up to date with the MASS crew, head over to massresearchreview.com You can follow Dr. Ormsbee's work and the work of his lab, and even take a course on body composition he's involved with using the following links Instagram @mike Ormsbee https://www.instagram.com/mikeormsbee/?hl=en @fsuissm https://www.instagram.com/fsuissm/ https://www.thegreatcourses.com/courses/changing-body-composition-through-diet-and-exercise?fbclid=IwZXh0bgNhZW0CMTEAAR0UlSymishRP9a0LsEV9M426b3ojQrU-As81zLkafYwuz48Po8Qdzkk3iw_aem_sdFSaB4a109dHMmHXK9WUQ 00:00 Introduction to an episode with two Mikes and one Eric https://sportsnutritionassociation.com/sna-annual-2025-conference/ 05:26 Introducing Dr Mike Ormsbee properly 08:01 Resistance training is fat loss training 22:09 Concurrent training and equating aerobic and resistance training in studies 28:39 Adaptations to exercise and fat burning vs fat loss Jo 2019 Resistance training during a 12-week protein supplemented VLCD treatment enhances weight-loss outcomes in obese patients https://pubmed.ncbi.nlm.nih.gov/29352654/ Murphy 2022 Energy deficiency impairs resistance training gains in lean mass but not strength: A meta-analysis and meta-regression https://pubmed.ncbi.nlm.nih.gov/34623696/ So 2014 Exercise-induced myokines in health and metabolic diseases https://pubmed.ncbi.nlm.nih.gov/28664094/ Vechetti 2021 Mechanical overload-induced muscle-derived extracellular vesicles promote adipose tissue lipolysis https://pubmed.ncbi.nlm.nih.gov/34033143/ 42:51 The many mechanisms involved with fat loss outcomes 53:01 Is spot reduction possible? And considering science when making recommendations 1:04:20 Dr Ormsbee's current and future projects and the evolution of methods Snijders 2015 Protein Ingestion before Sleep Increases Muscle Mass and Strength Gains during Prolonged Resistance-Type Exercise Training in Healthy Young Men https://pubmed.ncbi.nlm.nih.gov/25926415/ Falkenberg 2021 Nutrient intake, meal timing and sleep in elite male Australian football players https://pubmed.ncbi.nlm.nih.gov/32624442/ 01:34:06 Final thoughts on sleep quality and closing out https://massresearchreview.com/

In this episode, Drs Trexler and Helms are joined by Dr. Eduardo De Souza to discuss the complexities and misconceptions surrounding high volume training in the context of hypertrophy research. He shares insights from his extensive research background, emphasizing the importance of understanding participant experiences and the nuances of training volume. The conversation also touches on the challenges of research methodology, the need for improved reporting standards, and the future directions of exercise science research. Time stamps: 0:00 Introducing Dr Eduardo De Souza and some housekeeping https://sportsnutritionassociation.com/sna-annual-2025-conference/ 4:23 Eduardo's background and work in high volume training research Scarpelli 2022 Muscle Hypertrophy Response Is Affected by Previous Resistance Training Volume in Trained Individuals https://pubmed.ncbi.nlm.nih.gov/32108724/ Enes 2024 Effects of Different Weekly Set Progressions on Muscular Adaptations in Trained Males: Is There a Dose-Response Effect? https://pubmed.ncbi.nlm.nih.gov/37796222/ 19:55 Measurement methods and errors Barsuhn 2025 Training volume increases or maintenance based on previous volume: the effects on muscular adaptations in trained males https://pubmed.ncbi.nlm.nih.gov/39665246/ 26:00 The participant experience in high volume research and oedema 41:40 Criticisms of research methods 48:29 The applications of Eduardo's research 59:12 Trained and untrained participants and future research de Souza 2007 Acute effect of two aerobic exercise modes on maximum strength and strength endurancehttps://pubmed.ncbi.nlm.nih.gov/18076237/ 1:09:46 The aspects of future research which excites Eduardo (and a sneak peak into some sleep research) 1:21:45 Closing out and where to find Dr Eduardo de Souza Instagram @dr.desouzaeo https://www.instagram.com/dr.desouzaeo/?hl=en

In tonight's episode of Iron Culture, Eric Trexler and Eric Helms discuss various topics related to fitness, training, and research. They share personal updates, including the toll that Helms' intense training regimen is taking on his face. The discussion then shifts to the upcoming NFL combine, highlighting the impressive athletic feats expected from past combine participants. In the main segment of the show, Trexler and Helms discuss the nuances of lengthened-biased training research – more specifically, why we shouldn't give up on the strategy just because a few studies reporting non-significant results have come along. In this conversation, Trexler and Helms explore the concept of sampling error in research, emphasizing the importance of understanding some foundational statistical concepts and the need for several studies to draw reliable conclusions. They explore the challenges of uncertainty in evidence-based practice, the balance to strike between mechanistic and empirical approaches to understanding exercise and nutrition, and the resistance to change in learning. Finally, they engage in a rapid-fire Q&A session addressing a handful of fitness-related questions. The MASS crew records Iron Culture LIVE on YouTube, Monday nights at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link: https://massresearchreview.com/ironculture Time Stamps: 00:00 Introduction and why Trexler is worried about Helms 6:40 Q&A NFL Combine analysis Trexler 2017 Fat-Free Mass Index in NCAA Division I and II Collegiate American Football Players https://pubmed.ncbi.nlm.nih.gov/27930454/ 13:18 Getting into the science with Helms' upcoming MASS article on long muscle length training Burke 2006 "Fat adaptation" for athletic performance: the nail in the coffin? https://pubmed.ncbi.nlm.nih.gov/16357078/ Nunes 2022 Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults https://pubmed.ncbi.nlm.nih.gov/35187864/ Larsen 2024 The effects of hip flexion angle on quadriceps femoris muscle hypertrophy in the leg extension exercise https://pubmed.ncbi.nlm.nih.gov/39699974/ Gschneider 2024 The effects of lengthened-partial range of motion resistance training of the limbs on arm and thigh muscle cross-sectional area https://sportrxiv.org/index.php/server/preprint/view/485/version/624 Wolf 2025 Lengthened partial repetitions elicit similar muscular adaptations as full range of motion repetitions during resistance training in trained individuals https://pubmed.ncbi.nlm.nih.gov/39959841/ Kassiano 2022 Does Varying Resistance Exercises Promote Superior Muscle Hypertrophy and Strength Gains? A Systematic Review https://pubmed.ncbi.nlm.nih.gov/35438660/ Pedrosa 2023 Training in the Initial Range of Motion Promotes Greater Muscle Adaptations Than at Final in the Arm Curl https://pubmed.ncbi.nlm.nih.gov/36828324/ 29:59 Simulating a large lengthened-bias training dataset 42:28 Some points from Trexler Trexler 2019 Acute Effects of Citrulline Supplementation on High-Intensity Strength and Power Performance: A Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/30895562/ 1:02:56 Mechanisms vs experimental trials (uncertainty) 1:10:15 Using Large Language Models for statistical analysis (in R) 1:21:01 Q&A Rapid fire 1: Work and energy expenditure during eccentric contractions 1:23:22 Q&A Rapid fire 2: Waited vest upsides and downsides 1:25:47 Q&A Rapid fire 3: Protein recommendations for individuals who don't train their entire body 1:29:20 Q&A Rapid fire 4: Sprint cycling for quad hypertrophy 1:35:04 Wrapping up See the entire MASS team speak at the Sports Nutrition Association Annual Conference https://sportsnutritionassociation.com/sna-annual-2025-conference/

Iron Culture is officially part of the 3-plate club. In this episode of Iron Culture, hosts Eric Trexler and Eric Helms celebrate their milestone 315th episode while diving into various topics including testosterone replacement therapy (TRT), the efficacy of citrulline malate, training techniques for hypertrophy, managing tendinopathy, the health benefits of coffee, and programming for individuals with obesity. They also discuss how to improve training intensity and the importance of enthusiasm in lifting. Time stamps: 0:00 Introduction to another addition of Iron Culture 1:35 See the entire MASS team speak at the Sports Nutrition Association Annual Conference https://sportsnutritionassociation.com/sna-annual-2025-conference/ 5:55 Questions about testosterone replacement therapy Iron Culture Ep. 136- All About Testosterone & TRT (Yeah We Go There) https://www.youtube.com/watch?v=U5PDtstlmJ0 Tang Fui 2017 The effects of testosterone on body composition in obese men are not sustained after cessation of testosterone treatment https://pubmed.ncbi.nlm.nih.gov/28561278/ 20:42 An update on citrulline malate 30:18 Quantifying volume of time-saving techniques Coleman 2022 Muscular Adaptations in Drop Set vs. Traditional Training: A meta-analysis https://journal.iusca.org/index.php/Journal/article/view/135 Sødal 2023 Effects of Drop Sets on Skeletal Muscle Hypertrophy: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/37523092/ 34:09 Eric's tips for working around tendinopathy 40:43 Is caffeine bad for teeth and substituting coffee for decaf? 47:31 Hip flexion training for rectus femoris hypertrophy 49:35 Resistance training prescription for people with obesity trying to lose weight 56:24 Defining and increasing training intensity 1:00:46 Training Hard Versus Training Smart

This episode of Iron Culture begins with a rant/story by Dr. Trexler that highlights some issues with scientific publishing. He describes a study on apple cider vinegar, his MASS article criticizing the study, and the subsequent letter to the editor (and response from the original authors). This discussion is followed by a Q&A session with Dr. Helms covering protein during weight loss, headaches from creatine, machines for joint comfort, mixing creatine + caffeine, low volume training for hypertrophy, biceps curl variations, fiber recommendations, and more. The MASS crew records Iron Culture LIVE on YouTube, Monday nights at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link: https://massresearchreview.com/ironculture/ Time stamps: 0:00 Introduction and where to submit your questions https://massresearchreview.com/ironculture/ 2:22 Sneak peak into a future MASS article and being careful when reading research Original Article: Abou-Khalil 2024 Apple cider vinegar for weight management in Lebanese adolescents and young adults with overweight and obesity: a randomised, double-blind, placebo-controlled study https://nutrition.bmj.com/content/7/1/e000823 Letter: Improbable data characteristics and extreme effects of apple cider vinegar on weight loss https://nutrition.bmj.com/content/early/2025/02/06/bmjnph-2024-000997 Response to Letter: Abou-Khalil 2024 Comprehensive clarification of statistical and data concerns on the effects of apple cider vinegar on weight loss https://pmc.ncbi.nlm.nih.gov/articles/PMC11773656/#R1 21:23 Final thoughts on the papers 28:18 Q&A 1 Protein intake during weight loss? Iron Culture Ep 313 - Is More (and More, and More) Protein Better for Muscle Retention https://www.youtube.com/watch?v=zWD83HYvJ_g Refalo 2025 Effect of Dietary Protein on Fat-Free Mass in Energy Restricted, Resistance-Trained Individuals: An Updated Systematic Review With Meta-Regression https://journals.lww.com/nsca-scj/fulltext/9900/effect_of_dietary_protein_on_fat_free_mass_in.179.aspx 30:04 Q&A 2 Headaches as a side-effect of creatine? 35:48 Q&A Rapid Fire: Machines for joints, hypertrophy of biarticular muscles with squats and deadlifts, 42:27 Q&A Rapid Fire 2: Creatine and caffeine, decaffeinated coffee 47:45 Q&A 3 Can low volume be optimal for hypertrophy? 51:36 Q&A 4 Hammer curls for maximal bicep gains? Kassiano Distinct muscle growth and strength adaptations after preacher and incline biceps curl https://pubmed.ncbi.nlm.nih.gov/39809454/ Zabaleta-Korta 2023 Regional Hypertrophy: The Effect of Exercises at Long and Short Muscle Lengths in Recreationally Trained Women https://pubmed.ncbi.nlm.nih.gov/37559762/ 58:30 Q&A 5 Up and downsides of fiber and some practical tips 1:03:05 Q&A Rapid Fire 3: Muscle length and peak contraction, different training for upper and low body, aerobic fitness with time-saving techniques Varovic 2024 Regional Hypertrophy with Resistance Training—Does Muscle Length Matter? https://sportrxiv.org/index.php/server/preprint/view/464#:~:text=In%20summary%2C%20our%20results%20indicate,to%20shorter%20mean%20muscle%20lengths de Salles 2010 Strength increases in upper and lower body are larger with longer inter-set rest intervals in trained men https://pubmed.ncbi.nlm.nih.gov/19811949/ 1:10:41 Closing out another wonderful episode of Iron Culture --- Music credit: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100806 Artist: http://incompetech.com/

In this episode of Iron Culture, hosts Dr. Eric Helms and Dr. Eric Trexler are joined by Dr. Martin Refalo to discuss their recent meta-regression study on protein intake and its effects on muscle hypertrophy. They cover Martin's background, the initiation of the project, the methods used, and key findings, followed by a discussion of some critiques that have been generating discussion on social media platforms. The conversation emphasizes the importance of understanding statistical approaches in research and the implications of their findings for the fitness community. In this conversation, the Erics and Martin discuss the complexities of statistical modeling in nutrition research, the importance of parsimony, the risks of overfitting, and the challenges of controlling for covariates. The conversation also touches on the debate surrounding scaling protein recommendations by fat-free mass versus total mass, critiques of previous research on protein requirements for hypertrophy, and the ways in which these new findings support (and contradict) the authors' previously held biases. Throughout the episode, they reflect on the evolution of research in the fitness industry and the importance of engaging with critiques and feedback. Ultimately, they emphasize the need for thoughtful, contextualized, individualized application of their findings while acknowledging key limitations of their work. Time stamps: 00:00 Introducing Dr Martin Refalo Iron Culture Ep. 197- Training To Failure: A Comprehensive Overview https://www.youtube.com/watch?v=oa8Z-fUuiNU 5:28 How did we get to the meta-regression and an overview of the methods Refalo 2025 Effect of Dietary Protein on Fat-Free Mass in Energy Restricted, Resistance-Trained Individuals: An Updated Systematic Review With Meta-Regression https://journals.lww.com/nsca-scj/fulltext/9900/effect_of_dietary_protein_on_fat_free_mass_in.179.aspx Helms 2014 A systematic review of dietary protein during caloric restriction in resistance trained lean athletes: a case for higher intakes https://pubmed.ncbi.nlm.nih.gov/24092765/ 20:49 The main findings 30:58 Addressing the critiques 44:08 Scaling protein recommendations to fat-free mass vs body mass and why there was no break-point analysis Morton 2018 A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults https://pubmed.ncbi.nlm.nih.gov/28698222/ Tagawa 2020 Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials https://pubmed.ncbi.nlm.nih.gov/33300582/ Nunes 2022 Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults https://pubmed.ncbi.nlm.nih.gov/35187864/ 1:07:45 The practical recommendations 1:22:49 Types and the categorization of data and the secondary analyses Murphy 2022 Energy deficiency impairs resistance training gains in lean mass but not strength: A meta-analysis and meta-regression https://pubmed.ncbi.nlm.nih.gov/34623696/ 1:39:02 Quick Q&A Software for systematic reviews and meta-analyses 1:40:45 Final thoughts on the research and closing out Where to find Martin: @mrfitness__ https://www.instagram.com/mrfitness__/?hl=en

In today's episode of Iron Culture, co-hosts Eric Helms and Eric Trexler are joined by MASS colleague Dr. Mike Zourdos. After a brief chat about bodybuilding, powerlifting, and college football news, the crew addresses a number of questions about topics including optimal protein intake, what soreness can (or can't) tell us, detraining & retraining, vegan protein sources, heavy metals in protein supplements, training volume recommendations, pre-sleep meal guidelines, and much more. The MASS crew records Iron Culture LIVE on YouTube, Monday nights at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! Time stamps: 0:00 Intro music 2:25 Introduction to an episode with a rare Mike Zourdos sighting Ask your questions here: https://massresearchreview.com/ironculture/ 6:30 Helms brings some bodybuilding news (with some college football chat) 17:15 2025 2025 Sheffield Powerlifting Championships recap 20:35 Preview for a future episode with Dr Refalo on recently published protein meta-regression Refalo 2025 Effect of Dietary Protein on Fat-Free Mass in Energy Restricted, Resistance-Trained Individuals: An Updated Systematic Review With Meta-Regression https://journals.lww.com/nsca-scj/fulltext/9900/effect_of_dietary_protein_on_fat_free_mass_in.179.aspx 21:55 Q&A 1 Rapid bounce back from a series of unfortunate events 27:51 Q&A 2 Is soreness useful for determining volume? Gomes 2019 High-Frequency Resistance Training Is Not More Effective Than Low-Frequency Resistance Training in Increasing Muscle Mass and Strength in Well-Trained Men https://pubmed.ncbi.nlm.nih.gov/29489727/ 40:25 Q&A 3 Protein 'rapid fire': vegan options, protein supplementation, and heavy metal contamination Nunes 2022 Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults https://pubmed.ncbi.nlm.nih.gov/35187864/ 1:06:10 Q&A 4 Strength progress, muscle growth and neurological adaptations Pelland 2024 The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain https://sportrxiv.org/index.php/server/preprint/view/460 Ralston 2017 The Effect of Weekly Set Volume on Strength Gain: A Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/28755103/ 1:13:06 Q&A 5 Individual volume recommendation specificity 1:25:01 Q&A 6 Pre-sleep meal timing and other habits for sleep quality 1:36:07 Closing out and a preview for next week's live episode --- Music credit: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Source: https://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100806 Artist: http://incompetech.com/

In Episode 311 of Iron Culture, hosts Dr. Eric Trexler, Dr. Eric Helms, and Dr. Lauren Colenso-Semple deliver a comprehensive exploration of hormones, health, and performance optimization. The episode opens with a deep dive into recent research on stretching protocols and muscle adaptations, examining groundbreaking case studies that challenge conventional wisdom about flexibility training and muscle growth. The centerpiece of this episode focuses on demystifying menopause, with the hosts providing an evidence-based breakdown of symptoms, treatment options, and common misconceptions about hormone therapy. They tackle the complex landscape of medical misinformation head-on, offering listeners practical guidance for seeking specialized care and making informed health decisions. The discussion extends to critical examinations of hormonal contraceptives and their relationship with breast cancer risk, providing nuanced insights into inflammation mechanisms and risk assessment. The episode concludes with an illuminating segment on male hormone replacement therapy and "andropause," building on their previous coverage of testosterone optimization. The MASS crew records Iron Culture LIVE on YouTube, Monday nights at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! Time Stamps: 0:00 Introduction and Eric's upcoming contest prep plan 3:34 Calf stretching case study breakdown 22:33 Why you need to listen to the following section 28:12 Menopause information and symptoms 40:49 Menopause and hormone therapy misinformation 50:54 The BS asymmetry principle, seeking specialist attention, and science communication 1:01:50 Breast cancer risk and inflammation with hormonal contraceptives 1:12:58 "Man-opause" and hormone replacement therapy for men 1:24:48 Wrapping up

In today's episode, Drs Trexler and Helms discuss a wide range of fitness topics including metabolic stress, "the pump," targeting the different heads of the biceps, individualising diets and supplement protocols, maximal rates of fat loss, blood flow restricted training, the philosophy of science, and much more! We had some technical issues while recording this episode live, but it's all fixed now with the wonders of editing. If you don't understand a couple of the jokes, they're referring to chaos that has been deleted. Time stamps: 00:00 Straight into the topic: why should anyone care about metabolic stress? 03:13 Helms takes a deep dive into energy systems and muscle physiology 12:37 Subjective and objective measures of the pump and potential influencing factors 22:12 Arterial and venous occlusion 29:35 Update on Trexler's training and Q&A 1 different curl variations 38:53 Q&A 2 Manipulating forearm position for the biceps? 42:42 Q&A 3 Can BFR increase vascularity? And an aside on muscle memory and testosterone 48:03 Q&A 4 Individualising supplements and diet 58:34 Q&A 5 Fat oxidation and maximum rate of fat loss per day with some applications for contest prep 1:13:42 Q&A 6 Science communicators/educators and the philosophy of science Larsen 2025 Knee flexion range of motion does not influence muscle hypertrophy of the quadriceps femoris during leg press training in resistance-trained individuals https://sportrxiv.org/index.php/server/preprint/view/502 Kubo 2019 Effects of squat training with different depths on lower limb muscle volumes https://pubmed.ncbi.nlm.nih.gov/31230110/ Iron Culture Ep. 109- Empiricism vs Rationalism: What Do We Really Know When It Comes To Fitness? https://www.youtube.com/watch?v=qT3KPnTgO7M 1:29:27 Q&A 7 Using BFR in practice 1:30:50 Closing out MASS Research Review https://massresearchreview.com/ --- Music credit: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... Source: http://incompetech.com/music/royalty-... Artist: http://incompetech.com/

In this episode of Iron Culture, Eric Helms and Trex discuss a variety of evidence-based fitness topics. In this conversation, Dr. Trexler and Dr. Helms delve into the complexities of muscle gain, recovery, and the role of nutrition in performance. They discuss the nuances of identifying plateaus in training, the impact of training volume, the importance of food quality, and how psychological factors can influence recovery and performance. The dialogue emphasizes the need for a balanced approach to training volume and exercise selection, as well as the impact of nutrition on overall health and performance in bodybuilding. They also discuss modern theories and practical applications surrounding body weight regulation and the neurophysiological factors influencing obesity. They explore the gravitosat theory, discuss the implications of muscle gain on body weight regulation, and examine the concept of upper and lower intervention points. Additionally, they touch on powerlifting training strategies and the significance of volume in strength training. Time stamps: 0:00 Music 5:08 Introduction to the new year and another episode (and learning through teaching) 14:48 Q&A 1: Navigating injuries and recovery with training 23:42 Q&A 2: Plateaus with low volumes and difficulties recovering from increasing volume 31:08 Trexler on the importance of exercise selection and prescribing set volumes for clients 45:31 Q&A 3 The role of food quality in performance and hypertrophy 1:00:07 Q&A 4 Bodyweight regulation and intervention points with muscle gain 1:04:14 Exploring the Gravitostat Theory 1:10:50 Lower intervention points: muscle and fat gain Speakman 2011 Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity https://pubmed.ncbi.nlm.nih.gov/22065844/ 1:16:12 Neurophysiology and bodyweight regulation 1:24:01 Practical Applications of Body Weight Theories 1:29:35 Powerlifting Insights and Training Strategies Andoulakis-Korakakis 2021 The Minimum Effective Training Dose Required for 1RM Strength in Powerlifters https://pubmed.ncbi.nlm.nih.gov/34527944/ Pelland 2024 The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain https://sportrxiv.org/index.php/server/preprint/view/460 1:33:31 Closing out another episode of Iron Culture presented by MASS https://massresearchreview.com/ MASS Office Hours: https://www.youtube.com/playlist?list=PLq2Hpu55tCKbaklI9h4Z5-2kJYf5T3ren

In this episode, Eric Helms is joined by returning guest, his fellow 3DMJ coach and WNBF Pro bodybuilder, Alberto Nuñez, who is also the male WNBF athlete rep. In addition, they are joined by first time guest Steff Noble, a WNBF Figure pro, experienced coach, and president of WNBF UK. The trio first reflects on what was arguably the most competitive natural bodybuilding season to date, and the overall state of drug free bodybuilding, which in many ways is flourishing. There is more interest, higher competitive levels, higher productive quality in some regions, and in some countries natural bodybuilding is growing faster than enhanced bodybuilding. In North America, while some federations are doing better than others, the market demand for natural bodybuilding is obvious, as the NPC has made a concerted push to enter the natural bodybuilding scene, promoting drug tested shows in the US and Canada (as well as overseas), and even offering the chance to turn pro at the biggest natural events, with promises of drug tested pro shows on the horizon. What does this mean for natural bodybuilding? Is this a good thing, a threat, the beginning of a new era, or the beginning of the end? Further, what does the natural bodybuilding community need to do collectively to secure its future? Join us in this episode as we review not only the 2024 natural bodybuilding season, but discuss the future of the sport. The MASS crew records Iron Culture LIVE on YouTube, every Monday night at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link: https://massresearchreview.com/office... Time stamps: 00:00 (Re)-introducing Berto and Steff while Helms discusses 'sports' 04:15 Steff's WNBF World's recap and natural bodybuilding journey 10:35 The differences and similarities between the UK and US bodybuilding scenes (with some Eric seed-planting) 17:14 Berto's WNBF World's experience and the rising standard of bodybuilding 24:22 Regional differences in bodybuilding 36:09 The promoting and production of shows 46:00 The shift in the bodybuilding athlete mindset 51:31 The growth of the sport and increasing number of federations 59:12 Discussing comparisons with Powerlifting 1:13:40 Time for natural bodybuilding to adapt or die 1:26:03 Final perspectives on the future of bodybuilding 1:33:00 Closing out

In this episode of Iron Culture presented by MASS, Dr. Eric Trexler and Dr. Eric Helms explore the science and debate surrounding lengthened partials, a training technique often celebrated for its hypertrophy and strength benefits. Drawing on recent studies, they discuss how emerging evidence challenges some hyperbolic claims of lengthened partials as a superior training method, suggesting instead that their effectiveness is highly context-dependent. The hosts advocate for viewing lengthened partials as a complementary, rather than revolutionary, tool in exercise programming. After the main discussion, the episode transitions into a series of listener questions, with Dr. Trexler sharing his renewed enthusiasm for training (and his current approach to training) as he recovers from surgery. The hosts also address topics like the importance of omega-3 intake during low-fat diets, the diminishing returns of high training volumes, practical applications of two-a-day training splits, and the impact of high-protein diets on digestive health, emphasizing fiber and dietary diversity. They also discuss caffeine's role in sleep disruption, underlining caffeine timing as an easy way to improve sleep quality, among many other topics. The MASS crew records Iron Culture LIVE on YouTube, every Monday night at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link: https://massresearchreview.com/office-hours/ Time stamps: 0:00 Intro music 2:30 Introduction to another episode of Iron Culture x MASS Office Hours 3:31 New pre-prints on lengthened partials Gschneider 2024 The effects of lengthened-partial range of motionresistance training of the limbs on arm and thigh musclecross-sectional area: a multi-site cluster trial https://sportrxiv.org/index.php/server/preprint/view/485 Hinson 2024 Mixing Up Muscle Lengths: The Effects of Manipulating Peak Torque At Different Muscle Lengths in the Elbow Flexors https://sportrxiv.org/index.php/server/preprint/view/486 16:33 Helms' breakdown of the literature Maeo 2023 Effects of hip extension training performed with full versus partial range of motion at long muscle lengths on muscle hypertrophy and sprint performance https://www.ecss.mobi/DATA/EDSS/C28/28-3269.pdf Kassiano 2023 Greater Gastrocnemius Muscle Hypertrophy After Partial Range of Motion Training Performed at Long Muscle Lengths https://pubmed.ncbi.nlm.nih.gov/37015016/ Pedrosa 2022 Partial range of motion training elicits favorable improvements in muscular adaptations when carried out at long muscle lengths https://pubmed.ncbi.nlm.nih.gov/33977835/ Werkhausen 2021 Adaptations to explosive resistance training with partial range of motion are not inferior to full range of motion https://pubmed.ncbi.nlm.nih.gov/33465838/ 25:23 Live chat Q&A 1 An update on Trexler's training 33:26 Q&A 2 Omega-3 intake with low fat diets 36:54 Q&A 3 Quantifying volume and finding the sweet spot Pelland 2024 The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain https://sportrxiv.org/index.php/server/preprint/view/460 43:25 Teasing the MASS research interpretation and statistics guide 54:37 Q&A 4 When to do two-a-days 58:05 Q&A 5 Digestive health with high protein diets 1:06:12 Q&A 6 Caffeine and sleep disruption 1:13:07 Rapid fire Q&A: efficiency tiers, kinetic chain, waking-up with earplugs, cross-fit athletes, Trex's injury and intervention, resistance profiles at different muscle lengths Plotkin 2023 Hip thrust and back squat training elicit similar gluteus muscle hypertrophy and transfer similarly to the deadlift https://pubmed.ncbi.nlm.nih.gov/37877099/ Kobayashi 2024 Distinct hypertrophy of the elbow flexors after incline versus preacher dumbbell curl training https://www.ecss.mobi/DATA/EDSS/C29/29-1752.pdf Zabaleta-Korta 2021 The role of exercise selection in regional Muscle Hypertrophy: A randomized controlled trial https://pubmed.ncbi.nlm.nih.gov/34743671/ Larsen 2024 Dumbbell versus cable lateral raises for lateral deltoid hypertrophy: an experimental study https://sportrxiv.org/index.php/server/preprint/view/487 1:32:37 Helms' objectivity from being a competitive bodybuilder and closing out https://massresearchreview.com/ --- Music credit: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... Source: http://incompetech.com/music/royalty-... Artist: http://incompetech.com/

In this crossover episode of Iron Culture, co-hosts Danny Lennon and Eric Trexler are joined by fitness professional and fellow Sports Nutrition Association (SNA) advisory board member Laurin Conlin. Together, they dive into the complex relationship between mental health, physique sports, and fitness coaching. Laurin shares her personal experiences and insights on how disordered eating and body image issues often arise in competitive physique sports, and how these behaviors can permeate into the broader fitness space. The conversation highlights strategies for recognizing and reducing harmful behaviors, the importance of revisiting problematic terminology in the industry, and the value of maintaining a holistic perspective in coaching. Practical advice for fitness practitioners is grounded in evidence-based approaches like motivational interviewing, helping coaches better support clients navigating these challenges. The episode concludes with resources for learning more about the SNA and its initiatives in advancing sports nutrition practice. Time stamps: 00:00 Introducing Laurin to this SNA crossover episode 06:05 What got Laurin into the mental health space and where does physique sport cross into disordered eating/body image disorder? 15:02 Recognising and reducing harmful behaviours and cognitions associated with competing in physique sport 28:20 Laurin's personal experiences and physique sport behaviours permeating into general health and fitness 35:51 Problematic terminology and looking at the bigger picture 45:51 Advice for health practitioners to help clients in this area Clifford & Curtis (2016) Motivational interviewing in nutrition and fitness. https://psycnet.apa.org/record/2015-33705-000 58:22 Closing out and where to find more information on the Sport Nutrition Association Website https://sportsnutritionassociation.com/ Board Members https://sportsnutritionassociation.com/advisory-board/

Who is the strongest? Is it the person with the biggest Powerlifting total? Weightlifting total? The current Worlds Strongest Man/Woman Champion? Or, perhaps, the current Arnold Strongman Classic Champion? It's an oft-debated question, typically occurring around the proverbial fitness water cooler. However, recently Dr. Kind, Dr. Veit, Dr. Heffernan, and our very own Dr. Helms made this debate into a multidisciplinary academic paper. Specifically, they asked the question through the lens of history, what has strength meant in society since the dawn of physical culture, what is strength philosophically, and finally, what is strength objectively, as measured in sport and exercise science? Join us as we discuss why asking this question is important, and how these very different disciplines turned out to be quite complementary in providing an answer. The MASS crew records Iron Culture LIVE on YouTube, every Monday night at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link: https://massresearchreview.com/office-hours/ Time stamps: 00:00 Welcoming back Dr Conor Heffernan from the Obelisk 2:35 Adrian and Walter (re)-introduction Kind 2023 Is bodybuilding a sport? https://www.tandfonline.com/doi/full/10.1080/00948705.2023.2234978 6:26 What is strength? Kind 2024 What is strength? https://sportrxiv.org/index.php/server/preprint/view/467 14:21 Who in society decides what strength is? 29:45 A philosophical breakdown of the definition of strength 36:54 Strength measures of interest 56:02 Skill, efficiency, and intentionality Bauman 1926 Observations on the Strength of the Chimpanzee and its Implications https://academic.oup.com/jmammal/article-abstract/7/1/1/866743 1:06:03 Eric's tirade on sports science and exploring different strength variables 1:12:36 Categorising strength feats 1:18:46 The final sign-off (more plates, more dates?)

In this episode of Iron Culture, hosts Eric Trexler and Eric Helms begin with a brief discussion of Trex's recent MASS article on the misapplication of modern pain science in the fitness industry. They then discuss the nuances of protein recommendations, debating the merits of using body weight versus fat-free mass as a basis for determining protein needs. The conversation also touches on current research trends in protein intake and hypertrophy. Trexler and Helms move on to discuss the effects of electrical muscle stimulation (EMS) on hypertrophy, the impact of aging on hypertrophy and training volume benchmarks, lengthened partials as a training technique, adaptation to cold training environments, the impact of biomechanics on injury, the psychological aspects of motivation in training, and more. The MASS crew records Iron Culture LIVE on YouTube, every Monday night at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link: https://massresearchreview.com/office-hours/ Time stamps: 00:00 Introduction: the MASS Black Friday Sale and Journal Club https://massresearchreview.com/ 7:47 Discussion on Pain Science and Misapplication in Fitness 15:25 Protein Recommendations: Body Weight vs. Fat-Free Mass Helms 2014 A systematic review of dietary protein during caloric restriction in resistance trained lean athletes: a case for higher intakes https://pubmed.ncbi.nlm.nih.gov/24092... 23:57 Current Research in Protein Intake and Hypertrophy Tagawa 2020 Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials https://pubmed.ncbi.nlm.nih.gov/33300... Morton 2018 A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults https://pubmed.ncbi.nlm.nih.gov/28698... 26:26 Protein Recommendations and Controversies Nunes 2022 Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults https://pubmed.ncbi.nlm.nih.gov/35187... 35:02 EMS for Hypertrophy 42:50 Age and Hypertrophy: Adjusting Volume for Older Lifters Pelland 2024 The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain https://sportrxiv.org/index.php/serve... 50:16 Trexler's Lengthened Partials Experience 54:57 Adapting to Training in the Cold 1:00:07 Asymmetries, Biomechanics, and Injury 1:08:08 Protein Requirements: Why is Everyone So Confident about 1.6g/kg/day? 1:11:39 Motivation in a Demotivating Environment and Goalsetting 1:27:51 Final Points on Motivation 1:31:48 Closing Out --- Turn your videos into live streams with https://restream.io --- Music credit: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... Source: http://incompetech.com/music/royalty-... Artist: http://incompetech.com/

This week we've got a MONSTER episode in the form of a live Q&A episode with Dr. Helms and Dr. Trexler. The Good Doctors begin with a recap of the recent WNBF World Championships, followed by an insightful discussion about whether or not humans have a "factory error" in our design that promotes obesity. This is followed by a number of listeners' questions about functional anatomy, exercise selection, the importance of the eccentric phase of a lift, factors impacting reps in reserve (RIR) accuracy, biceps contributions to back exercises, hypertrophy considerations for the deadlift exercise, mini-cuts, set-to-set fatigue, energy expenditure limits, "delayed" hypertrophy, how to tell if you're a creatine nonresponder, and velocity-based training. The MASS crew records Iron Culture LIVE on YouTube, every Monday night at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link: https://massresearchreview.com/office-hours/ Also, don't miss out on the MASS Black Friday Sale, which has already started! Learn more and take advantage of huge discounts at www.massresearchreview.com Time stamps: 0:00 Intro 5:30 WNBF Worlds recap 15:25 Do Humans Have a "Factory Error" in our Design That Promotes Obesity? Pontzer 2023 The provisioned primate: patterns of obesity across lemurs, monkeys, apes and humans https://pubmed.ncbi.nlm.nih.gov/37661747/ 25:45 How important is the eccentric portion of the lift for hypertrophy? Roig 2009 The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis https://pubmed.ncbi.nlm.nih.gov/18981046/ Schoenfeld 2010 The mechanisms of muscle hypertrophy and their application to resistance training https://pubmed.ncbi.nlm.nih.gov/20847704/ 37:15 Exercises with brace points Haugen 2023 Effect of free-weight vs. machine-based strength training on maximal strength, hypertrophy and jump performance - a systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/37582807/ 44:56 Biceps functional anatomy during back compound exercises and epistemology Pelland 2024 The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain https://sportrxiv.org/index.php/server/preprint/view/460/version/587 50:25 Muscles to hypertrophy to increase deadlift strength 57:55 Rapid fire questions – Q1 Mini-cuts and bulking 1:05:15 Q2 Bench repetition performance across sets 1:08:35 Q3 Extreme energy expenditure Areta 2024 Energetics of a World-Tour Female Road Cyclist During a Multistage Race (Tour de France Femmes) https://pubmed.ncbi.nlm.nih.gov/38796175/ Thurber 2019 Extreme events reveal an alimentary limit on sustained maximal human energy expenditure https://pubmed.ncbi.nlm.nih.gov/31183404/ 1:12:34 Q4 Latent or delayed hypertrophy following a diet Bjørnsen 2019 Delayed myonuclear addition, myofiber hypertrophy, and increases in strength with high-frequency low-load blood flow restricted training to volitional failure https://pubmed.ncbi.nlm.nih.gov/30543499/ Damas 2016 Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage https://pubmed.ncbi.nlm.nih.gov/27219125/ 1:31:26 Q5 Where to find information on velocity-based training https://massresearchreview.com/ 1:37:16 Closing out --- Turn your videos into live streams with https://restream.io --- Music credit: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100806 Artist: http://incompetech.com/

In this Iron Culture, Sigma Nutrition Radio, SNA crossover, Dr. Joe Klemczewski returns! Dr. Joe, possibly the first online bodybuilding coach and person to advise clients to track macros before IIFYM was an acronym, joins us to reflect on the past and help us navigate the future. In the modern information age, there is more information than ever, which is a good thing, right? Perhaps, except that there is also more misinformation and disinformation than ever as well. While the evidence-based movement solved the problem of information inadequacy, we now face a much more complex problem of information illiteracy. What can you do to better navigate the "fake news" littering all aspects of social media, especially the nutrition space, and how can you facilitate better critical thinking in your clients and followers to reduce the likelihood they will undertake harmful diets? In this episode we tackle just that, discussing how paying attention to history and social changes can provide protection against modern fads. Time stamps: 00:00 Danny, Erich? And sending our condolences to the listeners https://raskolapparel.com/ 02:37 Re-introducing Dr. Joe Klemczewski 09:57 Changes in science 18:01 Science education for the consumer 26:53 How Dr. Joe communicates science with nuance to different audiences and how society (and social media) operates to perpetuate beliefs 36:59 Discerning truth and fact from context – using the recent meta-regressions on volume and frequency as an example Pelland 2024 The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain https://sportrxiv.org/index.php/server/preprint/view/460 51:00 The psychology of persuasion 59:34 Embedding heuristics and the utility of AI in academia 1:09:50 Broader trends in society, marketing strategies and delivering what is expected 1:21:46 Recapping the episode and closing out (be wary of Eric's positivity propaganda)

Even among the many monster episodes of Iron Culture, today's episode truly stands out. First, the MASS crew discusses this new era of Iron Culture and lets the cult know what they can expect as the show pushes forward and climbs to new heights. After that, the crew has an insightful discussion about the science of satellite cells – what they are, when they might (or might not) matter, and how they intersect with many hypertrophy-related topics, such as sex differences, aging, muscle damage, and factors that limit long-term muscle growth. The MASS crew records Iron Culture LIVE on YouTube, every Monday night at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat! If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link: https://massresearchreview.com/office-hours/ Time stamps 0:00 Intro 0:21 Big announcements about the future of Iron Culture and MASS Office Hours 5:10 Helms reflects on "the merger" 7:04 Re-introducing Dr. Mike Zourdos 17:53 Re-introducing Dr. Lauren Colenso-Semple 26:38 Dr. Helms' recent research 30:46 Dr. Trexler's current research 34:20 A primer on satellite cells 49:31 The role of satellite cells during growth/maturation and during use of exogenous anabolics 51:21 Sex differences and exogenous anabolics 53:52 The impact of aging on satellite cells and their function 58:54 Do satellite cell responses to muscle damage play a major role in muscle growth? 1:02:37 Do satellite cells and myonuclear domain theory become more relevant for muscle growth when the magnitude of growth becomes more substantial? 1:10:01 Does hard training induce muscle hyperplasia? 1:19:06 If meaningful muscle hyperplasia does occur in response to resistance training, does that impact how we should approach or design training programs? 1:24:39 Wrapping up

I'm going to break the fourth wall here and speak directly to our dear listeners. When we started this podcast almost six years ago, I never imagined it would last this long or become such a fixture in the community. The goal was always to create a space aimed at enriching the listener's appreciation and understanding of lifting. I want to thank every single person who has tuned in, supported throughout the years and engaged with us in this journey. I feel very confident in the future direction of Iron Culture with the two Erics taking lead. We'll catch you in that next episode from now, until the end of time. With heartfelt gratitude, Omar Time stamps: 00:00 Erics… Omar 03:09 Reviewing reviews (including one from Dr. RayGun) 08:04 Future horizons and looking back 19:56 Trexler's anniversary and some reflections 27:20 Climate change isn't real… the science is the science and a quick update on the Iron Culture documentary 31:40 Trexler's commentary and how he came to be on the cult 42:24 Helms reflects on some memorable episodes and guests 48:52 The Iron Culture mission statement 56:51 The future of Iron Culture (including the interview of a certain guest) 1:08:50 The running Iron Culture jokes 1:16:14 Coming full circle with some final thoughts

In this Iron Culture/Sports Nutrition Association/Sigma Nutrition Radio crossover episode, host Eric Helms is joined by co-host Danny Lennon and guest Alex Thomas. Alex is the president of the Sports Nutrition Association who started this association years ago when he was rudely awakened to the fact that he couldn't provide nutrition advice in his personal training clinic, despite having done so for years, having an RD on staff, and getting a degree in exercise science and nutrition. This prompted him to do a deep dive into scope of practice, insurance, legal requirements to provide nutrition coaching, and eventually to realise just how large of a gap there is in the nutrition coaching industry. Becoming aware of how common coach negligence leading to poorer consumer health is, spurred him to create the Sports Nutrition Association. Now SNA seeks to elevate the profession of nutrition coaching and protect the public. In this episode we navigate the confusing world of scope of practice, both legally and from a liability perspective, and why it's not only an important box ticking exercise, but a fundamental part of serving your clients. Time stamps: 00:00 Introduction to a podcast that needs a longer name and title 01:32 What is the Sports Nutrition Association? 06:15 Protected titles, scope of practice, and insurance 22:30 The importance of scope of practice and advice for practitioners 38:58 Trends and big claims in the space, risk/reward and consequences 51:36 Areas where practitioners should focus on and what to do going forward 1:00:06 The career pyramid for nutritionists 1:02:01 Closing out and where to find out more about the SNA Website https://sportsnutritionassociation.com/ Instagram @sportsnutritionassociation https://www.instagram.com/sportsnutritionassociation/ Sigma Nutrition Radio https://sigmanutrition.com/podcast-welcome/

In this Iron Culture/Sports Nutrition Association/Sigma Nutrition Radio crossover episode, host Eric Trexler is joined by co-host Danny Lennon and guest Dr. Shawn Arent. Dr. Arent is a professor and department chair at the University of South Carolina with a wealth of knowledge and research experience pertaining to nutritional strategies and supplements purported to support brain health and function. In this meeting of the minds, Eric, Danny, and Dr. Arent discuss the brain-related effects of carbohydrate, amino acids, caffeine (and caffeine-related substances), theanine, nicotine, fish oil, creatine, and much more. If you're interested in preserving the health and function of your brain, listening to this episode is certainly a smart decision. 00:00 Introduction to another crossover episode and Dr Shawn Arent 03:20 Defining cognitive performance and function 07:48 The acute effects of carbohydrates and caffeine on fatigue 13:01 Carbohydrate mouth rinsing and glycogen depletion (and are bodybuilders athletes?) 26:15 The (non-linear) glycogen utilisation response to exercise 29:53 The role of protein (EAAs and BCAAs) on cognitive function Daivs 1999 Effects of branched-chain amino acids and carbohydrate on fatigue during intermittent, high-intensity running https://pubmed.ncbi.nlm.nih.gov/10452228 36:06 Caffeine dose-response relationship on cognition 40:50 Caffeine timing and dosing strategies 51:38 Optimisation and thinking outside the box to minimise the effects of caffeine on sleep 55:18 Other (interesting) supplements with less evidence 1:01:28 Nicotine and sports culture 1:08:52 Supplementation for brain health and recommendations/protocols for TBIs 1:21:22 Closing out with some final take homes

In this crossover episode of Iron Culture and MASS Office Hours, Dr. Trexler is joined by special guest Josh Pelland, a coach for Data Driven and a PhD candidate at Florida Atlantic University, to discuss Pelland's recent meta-analysis which investigates the effects of training volume and frequency on hypertrophy and strength outcomes. These data have created a lot of stir in the evidence based community as very high volumes seem to be associated with hypertrophy without a definitive plateau. But as you can expect, there's much more to the story. The analysis synthesizes data from numerous studies and quantifies dose-response relationships by which higher training volumes and/or frequencies may lead to greater strength and muscle gains in response to resistance training. In a thorough discussion of the paper, Pelland discusses nuances, such as the point of diminishing returns where further volume or frequency may yield less significant gains, and highlights how individual factors like training experience and muscle group-specific responses affect outcomes. Practical recommendations include tailoring volume to individual needs, utilizing periodization and volume cycling to maximize adaptations, and addressing common pitfalls such as overtraining. Further, in this live episode audience questions drive deeper exploration into the practical implications of the findings and strategies for optimizing training programs based on current evidence. If you liked this crossover, remember the MASS crew goes live for Office Hours every Wednesday night at 7pm eastern time. Be sure to join them for a future episode! 0:00 Introduction to another official crossover episode MASS Office Hours Episode 58 (Is More Volume Always Better?) https://www.youtube.com/watch?v=0HErS8Hw12k 02:00 Getting to know Josh Pelland 07:35 An overview of Josh's new preprint Pelland 2024 The Resistance Training Dose-Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gain https://sportrxiv.org/index.php/server/preprint/view/460 Data Driven Strength Podcast - Volume and Hypertrophy: New Science Explained | S2E1 https://www.youtube.com/watch?v=yKRAVrf-798&t=0s Data Driven Strength Podcast - Frequency and Hypertrophy: New Science Explained | S2E2 https://www.youtube.com/watch?v=1rxOj92Q4p8 14:01 The search strategy and volume/frequency quantification method comparison 25:43 Statistical models 30:51 Volume results 39:32 Volume efficiency tiers 1:08:47 Frequency results 1:16:43 Q&A Question 1: How was the volume of different exercises quantified? 1:18:36 Question 2: Disconnect between theoretical vs practical optimum? 1:25:00 Question 3: How were different set structures, intensification techniques, and proximity-to-failure accounted for? 1:28:55 Question 4: Recommendations for 6x/week Full Body Powerbuilding training? 1:30:53 Question 5: The potential effects of different partials and ranges of motion? 1:34:45 Question 6: Did the studies measure both hypertrophy and strength outcomes? 1:36:10 Question 7: Strength training recommendations for sprint cyclers? 1:39:03 Question 8: Upper vs lower body set volume tolerance? 1:40:45 Question 9: Moderator analyses on the impact of training status? 1:42:50 Question 10: How do you know if you are performing too much volume? 1:46:36 Wrapping up and where to find Josh Data Driven Strength YouTube https://www.youtube.com/@datadrivenstrength Instagram @josh.datadrivenstrength https://www.instagram.com/josh.datadrivenstrength/?hl=en

There is a great deal of fitness content about strategically modifying your diet or changing your physique. Many of these strategies may appear to be simple on paper, but they are inseparable from the complexity of human perception and emotion. Whether we like it or not, diet or physique manipulation inherently interact with concepts relating to one's confidence, body image, self-esteem, and relationship with food. Further, many fitness coaches and clients mistakenly believe that poor body image or self-esteem are improved by simply changing one's body. A growing area of interest in the fitness space aims to directly address and improve these outcomes by focusing on beliefs and behaviors in the absence of physique manipulation. In this crossover episode with Sigma Nutrition Radio and the Sports Nutrition Association, Eric Trexler and Danny Lennon are joined by Dr. Gabrielle Fundaro to take an evidence-based and practical look at the ways diet or physique modifications interact with confidence, body image, and self-worth. 00:00 Welcome to another crossover episode (passively) dominated by Iron Culture 02:09 Defining body image and self-esteem 07:49 Relationship with food and weight stigma 21:22 Are your behaviours and beliefs really sustainable? 32:13 Different approaches to safe weight modification 39:19 Screening for risk factors and contraindications 47:20 Scope of practice and individuals who fall into the gaps 53:20 Interventions and approaches for improving body image 58:28 Closing out with some links Sports Nutrition Association https://sportsnutritionassociation.com/ Sigma Nutrition https://sigmanutrition.com/

The Iron Culture universe is expanding! In this crossover episode the host of Sigma Nutrition Radio, Danny Lennon, joins Eric Helms to co-host! Dr. Cliff Harvey, who did his PhD on ketogenic diets at AUT, joins Danny and Eric to discuss the often conflicting research and anecdotes on the effect of carbohydrates on lifting performance, adaptations and body composition change. Eric, Danny and Cliff are all on the Sports Nutrition Association (SNA) advisory board - an organisation dedicated to supporting the profession of sports nutrition. The board is packed with nutrition experts with a ton of experience. This is the first of many crossover episodes to come where Iron Culture, Sigma Nutrition Radio, and the SNA combine forces to bring you the best practical, science-based nutrition content possible! 00:00 Danny? Entering the multiverse (Sigma Iron Culture Nutrition Radio Ultra Podcast Show) 02:00 An update on carbohydrates for resistance training performance 05:34 The spectrum of carbohydrate intake related to work demands and Cliff's approach 15:13 The complexities of substrate utilisation and glycogen replenishment Hokken 2021 Subcellular localization- and fibre type-dependent utilization of muscle glycogen during heavy resistance exercise in elite power and Olympic weightlifters https://pubmed.ncbi.nlm.nih.gov/32961628/ King 2022 The Ergogenic Effects of Acute Carbohydrate Feeding on Resistance Exercise Performance: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/35809162/ Naharudin 2019 Breakfast Omission Reduces Subsequent Resistance Exercise Performance https://pubmed.ncbi.nlm.nih.gov/30707135/ Naharudin 2020 Viscous placebo and carbohydrate breakfasts similarly decrease appetite and increase resistance exercise performance compared with a control breakfast in trained males https://pubmed.ncbi.nlm.nih.gov/32174286/ 28:10 Intrasession carbohydrate intake and mouth rinsing King 2024 Isoenergetic pre-exercise meals varying in carbohydrate similarly affect resistance training volume performance compared to placebo https://sportrxiv.org/index.php/server/preprint/view/443/version/566 41:03 The placebo/nocebo effect related to food intake around training 53:30 Reconsidering nutrient timing and individualising coaching approaches 1:06:54 Goals, optimising approaches, and methodological considerations in the research Vargas-Molina 2020 Effects of a ketogenic diet on body composition and strength in trained women https://pubmed.ncbi.nlm.nih.gov/32276630/ Paoli 2021 Effects of Two Months of Very Low Carbohydrate Ketogenic Diet on Body Composition, Muscle Strength, Muscle Area, and Blood Parameters in Competitive Natural Body Builders https://pubmed.ncbi.nlm.nih.gov/33530512/ 1:17:11 Individual approaches to ketogenic diets and does macronutrient distribution really matter? Harvey 2019 Low-carbohydrate diets differing in carbohydrate restriction improve cardiometabolic and anthropometric markers in healthy adults: A randomised clinical trial https://pubmed.ncbi.nlm.nih.gov/30740270/ 1:25:48 Considerations for a low carbohydrate/ketogenic approach and ketosis misunderstandings 1:30:02 The take home and closing out