Idea Machines

Tim Hwang turns the tables and interviews me (Ben) about Speculative Technologies and research management.

Peter van Hardenberg talks about Industrialists vs. Academics, Ink&Switch's evolution over time, the Hollywood Model, internal lab infrastructure, and more! Peter is the lab director and CEO of Ink&Switch, a private, creator oriented, computing research lab. References Ink&Switch (and their many publications) The Hollywood Model in R&D Idea Machines Episode with Adam Wiggins Paul Erdós Transcript Peter Van Hardenberg [00:01:21] Ben: Today I have the pleasure of speaking with Peter van Hardenbergh. Peter is the lab director and CEO of Inkin switch. Private creator oriented, competing research lab. I talked to Adam Wiggins, one of inkind switches founders, [00:01:35] way back in episode number four. It's amazing to see the progress they've made as an organization. They've built up an incredible community of fellow travelers and consistently released research reports that gesture at possibilities for competing that are orthogonal to the current hype cycles. Peter frequently destroys my complacency with his ability to step outside the way that research has normally done and ask, how should we be operating, given our constraints and goals. I hope you enjoy my conversation with Peter. Would you break down your distinction between academics and industrialists [00:02:08] Peter: Okay. Academics are people whose incentive structure is connected to the institutional rewards of the publishing industry, right? You, you publish papers. And you get tenure and like, it's a, it's, it's not so cynical or reductive, but like fundamentally the time cycles are long, right? Like you have to finish work according to when, you know, submission deadlines for a conference are, you know, you're [00:02:35] working on something now. You might come back to it next quarter or next year or in five years, right? Whereas when you're in industry, you're connected to users, you're connected to people at the end of the day who need to touch and hold and use the thing. And you know, you have to get money from them to keep going. And so you have a very different perspective on like time and money and space and what's possible. And the real challenge in terms of connecting these two, you know, I didn't invent the idea of pace layers, right? They, they operate at different pace layers. Academia is often intergenerational, right? Whereas industry is like, you have to make enough money every quarter. To keep the bank account from going below zero or everybody goes home, [00:03:17] Ben: Right. Did. Was it Stuart Brand who invented pace [00:03:22] Peter: believe it was Stewart Brand. Pace layers. Yeah. [00:03:25] Ben: That actually I, I'd never put these two them together, but the, the idea I, I, I think about impedance mismatches between [00:03:35] organizations a lot. And that really sort of like clicks with pace layers Exactly. Right. Where it's like [00:03:39] Peter: Yeah, absolutely. And, and I think in a big way what we're doing at, Ink& Switch on some level is trying to provide like synchro mesh between academia and industry, right? Because they, the academics are moving on a time scale and with an ambition that's hard for industry to match, right? But also, Academics. Often I think in computer science are like, have a shortage of good understanding about what the real problems people are facing in the world today are. They're not disinterested. [00:04:07] Ben: just computer [00:04:08] Peter: Those communication channels don't exist cuz they don't speak the same language, they don't use the same terminology, they don't go to the same conferences, they don't read the same publications. Right. [00:04:18] Ben: Yeah. [00:04:18] Peter: so vice versa, you know, we find things in industry that are problems and then it's like you go read the papers and talk to some scientists. I was like, oh dang. Like. We know how to solve this. It's just nobody's built it. [00:04:31] Ben: Yeah. [00:04:32] Peter: Or more accurately it would be to say [00:04:35] there's a pretty good hunch here about something that might work, and maybe we can connect the two ends of this together. [00:04:42] Ben: Yeah. Often, I, I think of it as someone, someone has, it is a quote unquote solved problem, but there are a lot of quote unquote, implementation details and those implementation details require a year of work. [00:04:56] Peter: yeah, a year or many years? Or an entire startup, or a whole career or two? Yeah. And, and speaking of, Ink&Switch, I don't know if we've ever talked about, so a switch has been around for more than half a decade, right? [00:05:14] Peter: Yeah, seven or eight years now, I think I could probably get the exact number, but yeah, about that. [00:05:19] Ben: And. I think I don't have a good idea in my head over that time. What, what has changed about in, can switches, conception of itself and like how you do things. Like what is, what are some of the biggest things that have have changed over that time?[00:05:35] [00:05:35] Peter: So I think a lot of it co

A conversation with Tim Hwang about historical simulations, the interaction of policy and science, analogies between research ecosystems and the economy, and so much more. Topics Historical Simulations Macroscience Macro-metrics for science Long science The interaction between science and policy Creative destruction in research "Regulation" for scientific markets Indicators for the health of a field or science as a whole "Metabolism of Science" Science rotation programs Clock speeds of Regulation vs Clock Speeds of Technology References Macroscience Substack Ada Palmer's Papal Simulation Think Tank Tycoon Universal Paperclips (Paperclip maximizer html game) Pitt Rivers Museum Transcript [00:02:02] Ben: Wait, so tell me more about the historical LARP that you're doing. Oh, [00:02:07] Tim: yeah. So this comes from like something I've been thinking about for a really long time, which is You know in high school, I did model UN and model Congress, and you know, I really I actually, this is still on my to do list is to like look into the back history of like what it was in American history, where we're like, this is going to become an extracurricular, we're going to model the UN, like it has all the vibe of like, after World War II, the UN is a new thing, we got to teach kids about international institutions. Anyways, like, it started as a joke where I was telling my [00:02:35] friend, like, we should have, like, model administrative agency. You know, you should, like, kids should do, like, model EPA. Like, we're gonna do a rulemaking. Kids need to submit. And, like, you know, there'll be Chevron deference and you can challenge the rule. And, like, to do that whole thing. Anyways, it kind of led me down this idea that, like, our, our notion of simulation, particularly for institutions, is, like, Interestingly narrow, right? And particularly when it comes to historical simulation, where like, well we have civil war reenactors, they're kind of like a weird dying breed, but they're there, right? But we don't have like other types of historical reenactments, but like, it might be really valuable and interesting to create communities around that. And so like I was saying before we started recording, is I really want to do one that's a simulation of the Cuban Missile Crisis. But like a serious, like you would like a historical reenactment, right? Yeah. Yeah. It's like everybody would really know their characters. You know, if you're McNamara, you really know what your motivations are and your background. And literally a dream would be a weekend simulation where you have three teams. One would be the Kennedy administration. The other would be, you know, Khrushchev [00:03:35] and the Presidium. And the final one would be the, the Cuban government. Yeah. And to really just blow by blow, simulate that entire thing. You know, the players would attempt to not blow up the world, would be the idea. [00:03:46] Ben: I guess that's actually the thing to poke, in contrast to Civil War reenactment. Sure, like you know how [00:03:51] Tim: that's gonna end. Right, [00:03:52] Ben: and it, I think it, that's the difference maybe between, in my head, a simulation and a reenactment, where I could imagine a simulation going [00:04:01] Tim: differently. Sure, right. [00:04:03] Ben: Right, and, and maybe like, is the goal to make sure the same thing happened that did happen, or is the goal to like, act? faithfully to [00:04:14] Tim: the character as possible. Yeah, I think that's right, and I think both are interesting and valuable, right? But I think one of the things I'm really interested in is, you know, I want to simulate all the characters, but like, I think one of the most interesting things reading, like, the historical record is just, like, operating under deep uncertainty about what's even going on, right? Like, for a period of time, the American [00:04:35] government is not even sure what's going on in Cuba, and, like, you know, this whole question of, like, well, do we preemptively bomb Cuba? Do we, we don't even know if the, like, the warheads on the island are active. And I think I would want to create, like, similar uncertainty, because I think that's where, like, that's where the strategic vision comes in, right? That, like, you have the full pressure of, like, Maybe there's bombs on the island. Maybe there's not even bombs on the island, right? And kind of like creating that dynamic. And so I think simulation is where there's a lot, but I think Even reenactment for some of these things is sort of interesting. Like, that we talk a lot about, like, oh, the Cuban Missile Crisis. Or like, the other joke I had was like, we should do the Manhattan Project, but the Manhattan Project as, like, historical reenactment, right? And it's kind of like, you know, we have these, like, very, like off the cuff or kind of, like, stereotype visions of how these historical events occur. And they're very stylized. Yeah, exactly, right. And so the

Nadia Asparouhova talks about idea machines on idea machines! Idea machines, of course, being her framework around societal organisms that turn ideas into outcomes. We also talk about the relationship between philanthropy and status, public goods and more. Nadia is a hard-to-categorize doer of many things: In the past, she spent many years exploring the funding, governance, and social dynamics of open source software, both writing a book about it called "Working in Public" and putting those ideas into practice at GitHub, where she worked to improve the developer experience. She explored parasocial communities and reputation-based economies as an independent researcher at Protocol Labs and put those ideas into practice as employee number two at Substack, focusing on the writer experience. She's currently researching what the new tech elite will look like, which forms the base of a lot of our conversation. Completely independently, the two of us came up with the term "idea machines" to describe same thing — in her words: "self-sustaining organisms that contains all the parts needed to turn ideas into outcomes." I hope you enjoy my conversation with Nadia Asparouhova. Links Nadia's Idea Machines Piece Nadia's Website Working in Public: The Making and Maintenance of Open Source Software Transcript [00:01:59] Ben: I really like your way of, of defining things and sort of bringing clarity to a lot of these very fuzzy words that get thrown around. So, so I'd love to sort of just get your take on how we should think about so a few definitions to start off with. So I, in your mind, what, what is tech, when we talk about like tech and philanthropy what, what is that, what is that entity. [00:02:23] Nadia: Yeah, tech is definitely a fuzzy term. I think it's best to find as a culture, more than a business industry. And I think, yeah, I mean, tech has been [00:02:35] associated with startups historically, but But like, I think it's transitioning from being this like pure software industry to being more like, more like a, a way of thinking. But personally, I don't think I've come across a good definition for tech anywhere. It's kind, you know? [00:02:52] Ben: Yeah. Do, do you think you could point to some like very sort of like characteristic mindsets of tech that you think really sort of set it. [00:03:06] Nadia: Yeah. I think the probably best known would be, you know, failing fast and moving fast and breaking things. I think like the interest in the sort of like David and gly model of an individual that is going up against an institution or some sort of. Complex bureaucracy that needs to be broken apart. Like the notion of disrupting, I think, is a very tech sort of mindset of looking at a problem and saying like, how can we do this better? So it, in a [00:03:35] weird way, tech is, I feel like it's sort of like, especially in relation, in contrast to crypto, I feel like it's often about iterating upon the way things are or improving things, even though I don't know that tech would like to be defined that way necessarily, but when I, yeah. Sort of compare it to like the crypto mindset, I feel like tech is kind of more about breaking apart institutions or, or doing yeah. Trying to do things better. [00:04:00] Ben: A a as opposed. So, so could you then dig into the, the crypto mindset by, by contrast? That's a, I think that's a, a subtle difference that a lot of people don't go into. [00:04:10] Nadia: Yeah. Like I think the crypto mindset is a little bit more about building a parallel universe entirely. It's about, I mean, well, one, I don't see the same drive towards creating monopolies in the way that and I don't know if that was like always a, you know, core value of tech, but I think in practice, that's kind of what it's been of. You try to be like the one thing that is like dominating a market. Whereas with crypto, I think people are [00:04:35] because they have sort of like decentralization as a core value, at least at this stage of their maturity. It's more about building lots of different experiments or trying lots of different things and enabling people to sort of like have their own little corner of the universe where they can, they have all the tools that they need to sort of like build their own world. Whereas the tech mindset seems to imply that there is only one world the world is sort of like dominated by these legacy institutions and it's Tech's job to fix. Those problems. So it's like very much engaged with what it sees as kind of like that, that legacy world or [00:05:10] Ben: Yeah, I, I hadn't really thought about it that way. But that, that totally makes sense. And I'm sure other people have, have talked about this, but do, do you feel that is an artifact of sort of the nature of the, the technology that they're predicated on? Like the difference between, I guess sort of. The internet and the, the internet of, of like SAS and servers and then the [00:05:35] internet of like blockchains and distribute

Seemay Chou talks about the process of building a new research organization, ticks, hiring and managing entrepreneurial scientists, non-model organisms, institutional experiments and a lot more! Seemay is the co-founder and CEO of Arcadia Science — a research and development company focusing on underesearched areas in biology and specifically new organisms that haven't been traditionally studied in the lab. She's also the co-founder of Trove Biolabs — a startup focused on harnessing molecules in tick saliva for skin therapies and was previously an assistant professor at UCSF. She has thought deeply not just about scientific problems themselves, but the meta questions of how we can build better processes and institutions for discovery and invention. I hope you enjoy my conversation with Seemay Chou Links Seemay on Twitter (@seemaychou) Arcadia's Research Trove Biolabs Seemay's essay about building Arcadia Transcript [00:02:02] Ben: So since a lot of our conversation is going to be about it how do you describe Arcadia to a smart well-read person who has never actually heard of it before? [00:02:12] Seemay: Okay. I, I actually don't have a singular answer to this smart and educated in what realm. [00:02:19] Ben: oh, good question. Let's assume they have taken some undergraduate science classes, but perhaps are not deeply enmeshed in, in academia. So, so like, [00:02:31] Seemay: enmeshed in the meta science community.[00:02:35] [00:02:35] Ben: No, no, no, no, but they've, they, they, they, they they're aware that it's a thing, but [00:02:40] Seemay: Yeah. Okay. So for that person, I would say we're a research and development company that is interested in thinking about how we explore under researched areas in biology, new organisms that haven't been traditionally studied in the lab. And we're thinking from first principal polls about all the different ways we can structure the organization around this to also yield outcomes around innovation and commercialization. [00:03:07] Ben: Nice. And how would you describe it to someone who is enmeshed in the, the meta science community? [00:03:13] Seemay: In the meta science community, I would, I would say Arcadias are meta science experiment on how we enable more science in the realm of discovery, exploration and innovation. And it's, you know, that that's where I would start. And then there's so much more that we could click into on that. Right. [00:03:31] Ben: And we will, we will absolutely do that. But before we get there I'm actually really [00:03:35] interested in, in Arcadia's backstory. Cuz cuz when we met, I feel like you were already , well down the, the path of spinning it up. So what's, there's, there's always a good story there. What made you wanna go do this crazy thing? [00:03:47] Seemay: So, so the backstory of Arcadia is actually trove. Soro was my first startup that I spun out together with my co-founder of Kira post. started from a point of frustration around a set of scientific questions that I found challenging to answer in my own lab in academia. So we were very interested in my lab in thinking about all the different molecules and tick saliva that manipulate the skin barrier when a tick is feeding, but basically the, the ideal form of a team around this was, you know, like a very collaborative, highly skilled team that was, you know, strike team for like biochemical, fractionation, math spec, developing itch assays to get this done. It was [00:04:35] not a PhD style project of like one person sort of open-endedly exploring a question. So I was struggling to figure out how to get funding for this, but that wasn't even the right question because even with the right money, like it's still very challenging to set up the right team for this in academia. And so it was during this frustration that I started exploring with Kira about like, what is even the right way to solve this problem, because it's not gonna be through writing more grants. There's a much bigger problem here. Right? And so we started actually talking to people outside of academia. Like here's what we're trying to achieve. And actually the outcome we're really excited about is whether it could yield information that could be acted on for an actually commercializable product, right. There's like skin diseases galore that this could potentially be helpful for. So I think that transition was really important because it went from sort of like a passive idea to, oh, wait, how do we act as agents to figure out how to set this up correctly? [00:05:35] We started talking to angel investors, VCs people in industry. And that's how we learned that, you know, like itch is a huge area. That's an unmet need. And we had tools at our disposal to potentially explore that. So that's how tr started. And that I think was. The beginning of the end or the, the start of the beginning. However you wanna think about it. Because what it did, was it the process of starting trove? It was so fun and it was not at al

William Bonvillian does a deep dive about his decades of research on how DARPA works and his more recent work on advanced manufacturing. William is a Lecturer at MIT and the Senior Director of Special Projects,at MIT's Office of Digital Learning. Before joining MIT he spent almost two decades as a senior policy advisor for the US senate. He's also published many papers and a detailed book exploring the DARPA model. Links William's Website The DARPA Model for Transformative Technologies Transcript [00:00:35] In this podcast, William Bonvillian, and I do a deep dive about his decades of research about how DARPA works and his more recent work on advanced manufacturing. Well humans, a lecturer at MIT and a senior director of special projects at MIT is office of digital learning. Before joining MIT. He spent almost two decades as a senior policy advisor for the us Senate. He's published many papers and a detailed book exploring the DARPA model. I've wanted [00:01:35] to compare notes with him for years. And it was a pleasure. And an honor to finally catch up with him. Here's my conversation with William [00:01:42] Ben: The place that I I'd love to start off is how did you get interested in, in DARPA and the DARPA model in the first place you've been writing about it for more than a decade now. And, and you're probably one of the, the foremost people who who've explored it. So how'd you get there in the first. [00:01:58] William: You know, I, I I worked for the us Senate as a advisor in the Senate for for about 15 years before coming to MIT then. And I I worked for a us Senator who is on the on the armed services committee. And so I began doing a substantial amount of that staffing, given my interest in science technology, R and D and you know, got early contact with DARPA with some of DARPA's both program managers and the DARPA directors, and kind of got to know the agency that way spent some time with them over in their [00:02:35] offices. You know, really kind of got to know the program and began to realize what a, what a dynamic force it was. And, you know, we're talking 20, 20 plus years ago when frankly DARPA was a lot less known than it is now. So yeah, just like you know, kind of suddenly finding this, this Jewelbox varied in the. It was it was a real discovery for me and I became very, very interested in the, kind of the model they had, which was so different than the other federal R and D agencies. [00:03:05] Ben: Yeah. And, and actually um, It sort of in your mind, what is the for, for people who I, I think tend to see different federal agencies that give money to researchers as, as all being in the same bucket. What, what do you, what would you describe the difference between DARPA and the NSF as being [00:03:24] William: well? I mean, there's a big difference. So the NSF model is to support basic research. And they have, you know, the equivalent of project [00:03:35] managers there and they, they don't do the selecting of the research projects. Instead they queue up applicants for funds and then they supervise a peer review process. Of experts, you know, largely from academia who evaluate, you know, a host of proposals in a, in a given R and D area mm-hmm and and make valuations as to which ones would qualify. What are the kind of best most competitive applicants for NSFs basic research. So DARPA's got a different project going on, so it doesn't work from the bottom up. It, it has strong program managers who are in effect kind of empowered to go out and create new things. So they're not just, you know, responding to. Grant applications for basic research, they come into DARPA and develop a [00:04:35] vision of a new breakthrough technology area. They wanna stand up. And so it's, and there's no peer review here. It's really, you hire talented program managers. And you unleash them, you turn them loose, you empower them to go out and find the best work that's going on in the country. And that's, that can be from, from universities and often ends in this breakthrough technology area they've identified. But it also could be from comp companies, often smaller companies and typically they'll construct kind of a hybrid model where they've got academics. Companies working on a project, the companies are already always oriented to getting the technology out the door. Right. Cause they have to survive, but the researchers are often in touch with some of the more breakthrough capabilities behind the research. So bringing those two together is something that the program manager at DARPA does. So while at [00:05:35] NSF, the program manager equivalent, you know, their big job is getting grant out the door and supervising a complex selection process by committee mm-hmm . The role of the, of the ARPA of the, of the DARPA program manager is selecting the award winners is just the beginning of the job. Then in effect you move into their home, right? You work with them on an ongoing basis. DARPA program managers are s

In this conversation, Adam Falk and I talk about running research programs with impact over long timescales, creating new fields, philanthropic science funding, and so much more. Adam is the president of the Alfred P. Sloan Foundation, which was started by the eponymous founder of General Motors and has been funding science and education efforts for almost nine decades. They've funded everything from iPython Notebooks to the Wikimedia foundation to an astronomical survey of the entire sky. If you're like me, their name is familiar from the acknowledgement part of PBS science shows. Before becoming the president of the Sloan Foundation, Adam was the president of Williams College and a high energy physicist focused on elementary particle physics and quantum field theory. His combined experience in research, academic administration, and philanthropic funding give him a unique and fascinating perspective on the innovation ecosystem. I hope you enjoy this as much as I did. Links - The Sloan Foundation - Adam Falk on Wikipedia - Philanthropy and the Future of Science and Technology Highlight Timestamps - How do you measure success in science? [00:01:31] - Thinking about programs on long timescales [00:05:27] - How does the Sloan Foundation decide which programs to do? [00:08:08] - Sloan's Matter to Life Program [00:12:54] - How does the Sloan Foundation think about coordination? [00:18:24] - Finding and incentivizing program directors [00:22:32] - What should academics know about the funding world and what should the funding world know about academics? [00:28:03] - Grants and academics as the primary way research happens [00:33:42] - Problems with grants and common grant applications [00:44:49] - Addressing the criticism of philanthropy being inefficient because it lacks market mechanisms [00:47:16] - Engaging with the idea that people who create value should be able to capture that value [00:53:05] Transcript [00:00:35] In this conversation, Adam Falk, and I talk about running research programs with impact over long timescales, creating new fields, philanthropic science funding, and so much more. Adam is the president of the Alfred P Sloan foundation, which was started by the eponymous founder of general motors. And has been funding science and education efforts for almost nine decades. They funded everything from IP. I fond [00:01:35] notebooks to Wikimedia foundation. To an astronomical survey of the entire sky. If you're like me, their name is familiar from the acknowledgement part of PBS science shows. Before becoming the president of the Sloan foundation. Adam was the president of Williams college and I high energy physicist focused on elementary particle physics in quantum field theory. His combined experience in research. Uh, Academic administration and philanthropic funding give him a unique and fascinating perspective on the innovation ecosystem i hope you enjoy this as much as i did [00:02:06] Ben: Let's start with like a, sort of a really tricky thing that I'm, I'm myself always thinking about is that, you know, it's really hard to like measure success in science, right? Like you, you know, this better than anybody. And so just like at, at the foundation, how do you, how do you think about success? Like, what is, what does success look like? What is the difference between. Success and failure mean to [00:02:34] Adam: you? [00:02:35] I mean, I think that's a, that's a really good question. And I think it's a mistake to think that there are some magic metrics that if only you are clever enough to come up with build them out of citations and publications you could get some fine tune measure of success. I mean, obviously if we fund in a scientific area, we're funding investigators who we think are going to have a real impact with their work individually, and then collectively. And so of course, you know, if they're not publishing, it's a failure. We expect them to publish. We expect people to publish in high-impact journals, but we look for broader measures as well if we fund a new area. So for example, A number of years ago, we had a program in the microbiology of the built environment, kind of studying all the microbes that live in inside, which turns out to be a very different ecosystem than outside. When we started in that program, there were a few investigators interested in this question. There weren't a lot of tools that were good for studying it. [00:03:35] By 10 years later, when we'd left, there was a journal, there were conferences, there was a community of people who were doing this work, and that was another measure, really tangible measure of success that we kind of entered a field that, that needed some support in order to get going. And by the time we got out, it was, it was going strong and the community of people doing that work had an identity and funding paths and a real future. Yeah. [00:04:01] Ben: So I guess one way that I've been thinking about it, it's just, it's almost like count

In this conversation, Semon Rezchikov and I talk about what other disciplines can learn from mathematics, creating and cultivating collaborations, working at different levels of abstraction, and a lot more! Semon is currently a postdoc in mathematics at Harvard where he specializes in symplectic geometry. He has an amazing ability to go up and down the ladder of abstraction — doing extremely hardcore math while at the same time paying attention to *how* he's doing that work and the broader institutional structures that it fits into. Semon is worth listening to both because he has great ideas and also because in many ways, academic mathematics feels like it stands apart from other disciplines. Not just because of the subject matter, but because it has managed to buck many of the trend that other fields experienced over the course of the 20th century. Links Semon's Website Transcript [00:00:35] Welcome back to idea machines. Before we get started, I'm going to do two quick pieces of housekeeping. I realized that my updates have been a little bit erratic. My excuse is that I've been working on my own idea machine. That being said, I've gotten enough feedback that people do get something out of the podcast and I have enough fun doing it that I am going to try to commit to a once a month cadence probably releasing on the pressure second [00:01:35] day of. Second thing is that I want to start doing more experiments with the podcast. I don't hear enough experiments in podcasting and I'm in this sort of unique position where I don't really care about revenue or listener numbers. I don't actually look at them. And, and I don't make any revenue. So with that in mind, I, I want to try some stuff. The podcast will continue to be a long form conversation that that won't change. But I do want to figure out if there are ways to. Maybe something like fake commercials for lesser known scientific concepts, micro interviews. If you have ideas, send them to me in an email or on Twitter. So that's, that's the housekeeping. This conversation, Simon Rezchikov and I talk about what other disciplines can learn from mathematics, creating and cultivating collaborations, working at different levels of abstraction. is currently a post-doc in mathematics at Harvard, where he specializes in symplectic geometry. He has an amazing ability to go up, go up and down the ladder of [00:02:35] abstraction, doing extremely hardcore math while at the same time, paying attention to how he's doing the work and the broader institutional structures that affect. He's worth listening to both because he has great ideas. And also because in many ways, academic mathematics feels like it stands apart from other disciplines, not just because of the subject matter, but because it has managed to buck many of the trends that other fields experience of the course of the 20th century. So it's worth sort of poking at why that happened and perhaps. How other fields might be able to replicate some of the healthier parts of mathematics. So without further ado, here's our conversation. [00:03:16] Ben: I want to start with the notion that I think most people have that the way that mathematicians go about a working on things and be thinking about how to work on things like what to work on is that you like go in a room and you maybe read some papers and you think really hard, and then [00:03:35] you find some problem. And then. You like spend some number of years on a Blackboard and then you come up with a solution. But apparently that's not that that's not how it actually works. [00:03:49] Semon: Okay. I don't think that's a complete description. So definitely people spend time in front of blackboards. I think the length of a typical length of a project can definitely. Vary between disciplines I think yeah, within mathematics. So I think, but also on the other hand, it's also hard to define what is a single project. As you know, a single, there might be kind of a single intellectual art through which several papers are produced, where you don't even quite know the end of the project when you start. But, and so, you know, two, a two years on a single project is probably kind of a significant project for many people. Because that's just a lot of time, but it's true that, you know, even a graduate student might spend several years working on at least a single kind of larger set of ideas because the community does have enough [00:04:35] sort of stability to allow for that. But it's not entirely true that people work alone. I think these days mathematics is pretty collaborative people. Yeah. If you're mad, you know, in the end, you're kind of, you probably are making a lot of stuff up and sort of doing self consistency checks through this sort of formal algebra or this sort of, kind of technique of proof. It makes you make sure helps you stay sane. But when other people kind of can think about the same objects from a different perspective, usually things go faster and at the

Professor Michael Strevens discusses the line between scientific knowledge and everything else, the contrast between what scientists as people do and the formalized process of science, why Kuhn and Popper are both right and both wrong, and more. Michael is a professor of Philosophy at New York University where he studies the philosophy of science and the philosophical implications of cognitive science. He's the author of the outstanding book "The Knowledge Machine" which is the focus of most of our conversation. Two ideas from the book that we touch on: 1. "The iron rule of science". The iron rule states that "`[The Iron Rule] directs scientists to resolve their differences of opinion by conducting empirical tests rather than by shouting or fighting or philosophizing or moralizing or marrying or calling on a higher power` in the book Michael Makes a strong argument that scientists following the iron rule is what makes science work. 2. "The Tychonic principle." Named after the astronomer Tycho Brahe who was one of the first to realize that very sensitive measurements can unlock new knowledge about the world, this is the idea that the secrets of the universe lie in minute details that can discriminate between two competing theories. The classic example here is the amount of change in star positions during an eclipse dictated whether Einstein or Newton was more correct about the nature of gravity. Links Michael's Website The Knowledge Machine on BetterWorldBooks Michael Strevens talks about The Knowledge Machine on The Night Science Podcast Michael Strevens talks about The Knowledge Machine on The Jim Rutt Show Automated Transcript [00:00:35] In this conversation. Uh, Professor Michael And I talk about the line between scientific knowledge and everything else. The contrast between what scientists as people do and the formalized process of science, why Coon and popper are both right, and both wrong and more. Michael is a professor of philosophy at New York university, where he studies the philosophy of science and the philosophical implications [00:01:35] of cognitive science. He's the author of the outstanding book, the knowledge machine, which is the focus of most of our conversation. A quick warning. This is a very Tyler Cowen ESCA episode. In other words, that's the conversation I wanted to have with Michael? Not necessarily the one that you want to hear. That being said I want to briefly introduce two ideas from the book, which we focus on pretty heavily. First it's what Michael calls the iron rule of science. Direct quote from the book dine rule states that the iron rule direct scientists to resolve their differences of opinion by conducting empirical tests, rather than by shouting or fighting or philosophizing or moralizing or marrying or calling on a higher power. In the book, Michael makes a strong argument that scientist's following the iron rule is what makes science work. The other idea from the book is what Michael calls the Taconic principle. Named after the astronomer Tycho Brahe, who is one of the first to realize that very sensitive measurements can unlock new [00:02:35] knowledge about the world. This is the idea that the secrets of the universe that lie into my new details that can discriminate between two competing theories. The classic example, here is the amount of change in a Star's position during an eclipse dictating whether Einstein or Newton was more correct about the nature of gravity. So with that background, here's my conversation with professor Michael strengthens. [00:02:58] Ben: Where did this idea of the, this, the sort of conceptual framework that you came up with come from? Like, what's like almost the story behind the story here. [00:03:10] Michael: Well, there is an interesting origin story, or at least it's interesting in a, in a nerdy kind of way. So it was interested in an actually teaching the, like what philosophers call that logic of confirmation, how, how evidence supports or undermines theories. And I was interested in getting across some ideas from that 1940s and fifties. Scientists philosophers of science these days [00:03:35] look back on it and think of as being a little bit naive and clueless. And I had at some point in trying to make this stuff appealing in the right sort of way to my students so that they would see it it's really worth paying attention. And just not just completely superseded. I had a bit of a gear shift looking at it, and I realized that in some sense, what this old theory was a theory of, wasn't the thing that we were talking about now, but a different thing. So it wasn't so much about how to assess how much a piece of evidence supports a theory or undermines it. But was it more a theory of just what counts as evidence in the first place? And that got me thinking that this question alone is, could be a important one to, to, to think about now, I ended up as you know, in my book, the knowledge machine, I'm putting my finger on that as the mo

A conversation with the VitaDAO core team. VitaDAO is a decentralized autonomous organization — or DAO — that focuses on enabling and funding longevity research. The sketch of how a DAO works is that people buy voting tokens that live on top of the Etherium blockchain and then use those tokens to vote on various action proposals for VitaDAO to take. This voting-based system contrasts with the more traditional model of a company that is a creation of law or contact, raises capital by selling equity or acquiring debt, and is run by an executive team who are responsible to a board of directors. Since technically nobody runs VitaDAO the way a CEO runs a company, I wanted to try to embrace the distributed nature and talk to many of the core team at once. This was definitely an experiment! The members of the core team in the conversation in no particular order: Tyler Golato Paul Kohlhaas Vincent Weisser Tim Peterson Niklas Rindtorff Laurence Ion Links VitaDAO Home Page An explanation of what a DAO is Molecule Automated Transcript VitaDAO [00:00:35] In This conversation. I talked to a big chunk of the VitaDAO core team. VitaDAO is a decentralized autonomous organization or Dao that focuses on enabling and funding. Longevity research. We get into the details in the podcast, but a sketch of how a DAO works is that people buy voting tokens that live on top of the Ethereum blockchain. And then they use those tokens to vote on [00:01:35] various action proposals for me to doubt to take. This voting based system contrasts with more traditional models of the company. That is a creation of law or contract raises capital by selling equity or acquiring debt, and is run by an executive team who are responsible to a board of directors. Since technically, nobody runs for you to doubt the way it CEO runs the company. I wanted to try to embrace the distributed nature and talk to many of the core team at once. This was definitely experiment. Uh, I think it's your day. Well, Oh, well, but I realize it can be hard to tell voices apart on a podcast. So I'll put a link to a video version. In the show notes. So without further ado, here's my conversation with Vita Dao. What I want to do so that listeners can put a voice to a name is I want to go around everybody say your name and then you say how you would pronounce the word VI T a D a O. Tim, would you say your name and then, and then pronounce the word that [00:02:35] that's kind of how I've done it. Yeah. And so I'm the longevity steward we can help kind of figure out deal flow on, edited out, so. Awesome. All right, Tyler, you're next on. It is definitively Vieta Dell. Yeah. And I also help out with the longevity steward group. I started starting longevity group and I'm the chief scientific officer and co-founder at molecule as well. And then Nicholas you're next on my screen. It's definitely beats it out. And I'm also a member of the longevity working group in this science communication group and also currently initiating and laptop. Great. And then Vinson. Yeah. So it's the same pronunciation weeded out, but I'm helping on the side and also on kind of like special projects, like this incline where that I took around, we had recently and yeah, in Lawrence. Lauren Sajjan Vieta thou. And I [00:03:35] also steward the deal flow group within the longevity working group. And I think we should all now say as a hive mind, Paul Paul has said at the same time, oh, sorry. I'm going to say bye to dad. Mess with her in yeah. Hi everyone. My name is Paul cohost. I would say, be to down. I actually wonder what demographics says, Vida, like RESA. We should actually look into that. It's interest, interesting community metric. I'm the CEO and co-founder of molecule and one of the co-authors of the VW. I also work very deeply on the economic side and then essentially help finalize deal structures. So essentially the funding deals that we've been carry through into molecule and yeah, very excited to be here today. And maybe we can jump back into Lawrence adjusted we well, [00:04:35] also, so the thing that's confusing to me is that I always assumed that the Vith came from the word vitality. Right. And so that's, that's where the idea of calling it a fight Vita doubt, right? Because like, I don't say vitality, I say fighting. In German, it's actually retaliatory. Yeah. So it's just like the stupid Anglo centrism that is from the Latin, I would say from the word life. Yeah. Cool. So to really sort of jump right in, I think there's the, to like, be very direct, like, can we like walk through the mechanics of how the, how, how everything actually works? Right. So I think listeners are probably familiar with sort of like the high level abstract concept of there's a bunch of people. They have tokens, they vote on deals you give researchers money to, to do work, but like, sort of [00:05:35] like very, very mechanical. How does the dowel work? Could you like walk us through maybe like, sort of a a core loo

Dr. Brian Arthur and I talk about how technology can be modeled as a modular and evolving system, combinatorial evolution more broadly and dig into some fascinating technological case studies that informed his book The Nature of Technology. Brian is a researcher and author who is perhaps best known for his work on complexity economics, but I wanted to talk to him because of the fascinating work he's done building out theories of technology. As we discuss, there's been a lot of theorizing around science — with the works of Popper, Kuhn and others. But there's been less rigorous work on how technology works despite its effects on our lives. Brian currently works at PARC (formerly Xerox PARC, the birthplace of personal computing) and has also worked at the Santa Fe institute and was a professor Stanford university before that. Links W. Brian Arthur's Wikipedia Page The Nature of Technology on Amazon W. Brian Arthur's homepage at the Santa Fe Institute Transcript Brian Arthur [00:00:00] In this conversation, Dr. Brian Arthur. And I talk about how technology can be modeled as modular and evolving system. Commentorial evolution more broadly, and we dig into some fascinating technological hae studies that informed your book, his book, the nature of tech. Brian is a researcher and author who is perhaps best known for his work on complexity economics. Uh, but I wanted to talk to him [00:01:00] because of the fascinating work he's done, building out theories of technology. Uh, as we discussed in the podcast, there's been a lot of theorizing around science, you know, with the works of popper and Kuhn and other. But there's has been much less rigorous work on how technology works despite its effect on our lives. As some background, Brian currently works at park formerly Xerox park, the birthplace of the personal computer, and has also worked at the Santa Fe Institute and was a professor at Stanford university before that. Uh, so without further ado, here's my conversation with Brian Arthur. Mo far less interested in technology. So if anybody asks me about technology immediately search. Sure. But so the background to this is that mostly I'm known for a new framework and economic theory, which is called complexity economics. I'm not the [00:02:00] only developer of that, but certainly one of the fathers, well, grandfather, one of the fathers, definitely. I was thinking one of the co-conspirators I think every new scientific theory like starts off as a little bit of a conspiracy. Yes, yes, absolutely. Yeah. This is no exception anyways. So that's what I've been doing. I'm I've think I've produced enough papers and books on that. And I would, so I've been in South Africa lately for many months since last year got back about a month ago and I'm now I was, as these things work in life, I think there's arcs, you know, you're getting interested in something, you work it out or whatever it would be. Businesses, you [00:03:00] start children, there's a kind of arc and, and thing. And you work all that out. And very often that reaches some completion. So most of the things I've been doing, we've reached a completion. I thought maybe it's because I getting ancient, but I don't think so. I think it was that I just kept working at these things. And for some reason, technologies coming back up to think about it in 2009, when this book came out, I stopped thinking about technology people, norm they think, oh yeah, you wrote this book. You must be incredibly interested. Yeah. But it doesn't mean I want to spend the rest of your life. Just thinking about the site, start writing this story, like writing Harry Potter, you know, it doesn't mean to do that forever. Wait, like writing the book is like the whole [00:04:00] point of writing the book. So you can stop thinking about it. Right? Like you get it out of your head into the book. Yeah, you're done. So, okay. So this is very much Silicon valley and I left academia in 1996. I left Stanford I think was I'm not really an academic I'm, I'm a researcher sad that those two things have diverged a little bit. So Stanford treated me extraordinarily well. I've no objections, but anyway, I think I'd been to the Santa Fe Institute and it was hard to come back to standard academia after that. So why, should people care about sort of, not just the output of the technology creation process, but theory behind technology. Why, why does that matter? Well[00:05:00] I think that what a fine in in general, whether it's in Europe or China or America, People use tremendous amount of technology. If you ask the average person, what technology is, they tell you it's their smartphone, or it's catch a tree in their cars or something, but they're, most people are contend to make heavy use of technology of, I count everything from frying pans or cars but we make directly or indirectly, enormously heavy use of technology. And we don't think about where it comes from. And so there's a few kind of tendencies and biase

In this Conversation, Jason Crawford and I talk about starting a nonprofit organization, changing conceptions of progress, why 26 years after WWII may have been what happened in 1971, and more. Jason is the proprietor of Roots of Progress a blog and educational hub that has recently become a full-fledged nonprofit devoted to the philosophy of progress. Jason's a returning guest to the podcast — we first spoke in 2019 relatively soon after he went full time on the project . I thought it would be interesting to do an update now that roots of progress is entering a new stage of its evolution. Links Roots of Progress Nonprofit announcement Transcript So what was the impetus to switch from sort of being an independent researcher to like actually starting a nonprofit I'm really interested in. Yeah. The basic thing was understanding or getting a sense of the level of support that was actually out there for what I was doing. In brief people wanted to give me money and and one, the best way to receive and manage funds is to have a national nonprofit organization. And I realized there was actually enough support to support more than just myself, which had been doing, you know, as an independent researcher for a year or two. But there was actually enough to have some help around me to basically just make me more effective and, and further the mission. So I've already been able to hire research [00:02:00] assistants. Very soon I'm going to be putting out a a wanted ad for a chief of staff or you know, sort of an everything assistant to help with all sorts of operations and project management and things. And so having these folks around me is going to just help me do a lot more and it's going to let me sort of delegate everything that I can possibly delegate and focus on the things that only I can do, which is mostly research and writing. Nice and sort of, it seems like it would be possible to take money and hire people and do all that without forming a nonprofit. So what what's sort of like in your mind that the thing that makes it worth it. Well, for one thing, it's a lot easier to receive money when you have a, an organization that is designated as a 5 0 1 C three tax status in the United States, that is a status that makes deductions that makes donations tax deductible. Whereas other donations to other types of nonprofits are not I had had issues in the past. One organization would want to [00:03:00] give me a grant as an independent researcher, but they didn't want to give it to an individual. They wanted it to go through a 5 0 1 C3. So then I had to get a new. Organization to sort of like receive the donation for me and then turn around and re grant it to me. And that was just, you know, complicated overhead. Some organizations didn't want to do that all the time. So it was, it was just much simpler to keep doing this if I had my own organization. And do you have sort of a broad vision for the organization? Absolutely. Yes. And it, I mean, it is essentially the same as the vision for my work, which I recently articulated in an essay on richer progress.org. We need a new philosophy of progress for the 21st century and establishing such a philosophy is, is my personal mission. And is the mission. Of the organization to just very briefly frame this in the I, the 19th century had a very sort of strong and positive, you know, pro progress vision of, of what progress was and what it could do for humanity and in the [00:04:00] 20th century. That optimism faded into skepticism and fear and distrust. And I think there are ways in which the 19th century philosophy of progress was perhaps naively optimistic. I don't think we should go back to that at all, but I think we need a, we need to rescue the idea of progress itself. Which the 20th century sort of fell out of love with, and we need to find ways to acknowledge and address the very real problems and risks of progress while not losing our fundamental optimism and confidence and will to, to move forward. We need to, we need to regain to recapture that idea of progress and that fundamental belief in our own agency so that we can go forward in the 21st century with progress. You know, while doing so in a way that is fundamentally safe and benefits all of humanity. And since you, since you mentioned philosophy, I'm really like, just, just ask you a very weird question. That's related to something that I've been thinking about. And [00:05:00] so like, in addition to the fact that I completely agree the philosophy. Progress needs to be updated, recreated. It feels like the same thing needs to be done with like the idea of classical liberalism that like it was created. Like, I think like, sort of both of these, these philosophies a are related and B were created in a world that is just has different assumptions than we have today. Have you like, thought about how the, those two, like those two sort of like philosophical updates. Yeah. So first off, just on that question of, of

In this conversation, Dr. Stephen Dean talks about how he created the 1976 US fusion program plan, how it played out and the history of fusion power in the US, technology program planning and management more broadly, and more. Stephen has been working on making fusion energy a reality for more than five decades. He did research on controlled fusion reactions in the 60s and in the 70s became a director at the Atomic energy commission which then became the Energy Research and Development Administration which *then* became the department of energy. In 1979 he left government to form the consultancy Fusion Power associates, where he still works. In 1976, he led the preparation of a report called "Fusion power by magnetic confinement" that laid out a roadmap of the work that would need to be done to turn fusion from a science experiment into a functional energy source. References Fusion Power by Magnetic Confinement Executive Summary Volume 1 Volume 2 Volume 3 Volume 4 Fusion Power Associates The notorious fusion never plot Adam Marblestone on technological roadmapping My hypotheses on program design (which were challenged by this conversation!) Fusion Energy Base (a good website on fusion broadly) ITER Transcript (Machine generated, so please excuse errors) [00:00:00] In this conversation, Dr. Steven Dean, and I talk about how he created the 1976 S fusion program plan, how it played out in the history of fusion power in the U S technology program, planning and management more broadly, and even more things. Steven has been working on making fusion energy a reality for more than five decades. He did research on control, fusion reactions in the 1960s and seventies, he became a director [00:01:00] at the atomic energy commission, which then became the energy research and development of administration, which then became the department of energy in 1979. He left government to form the consultancy fusion, power associates, where you still want. In 1976, he led the preparation of a report called fusion power by magnetic confinement that laid out a roadmap of the work that needed would need to be done to turn fusion from a science experiment, into a functional energy source. And if I can sort of riff about this for a minute, the thing is. Unlike what I sort of see as modern roadmaps, it lays out not just the sort of like plan of record to getting fusion, to be a real energy source, but lays out all the different possible scenarios in terms of funding, in terms of new technology that we can't even think of being created and lays everything. Yeah. In a way that you can actually sort of make decisions off of it. [00:02:00] And I think one of the most impressive things is that it has several different what it calls logics of funding, which is like different, different funding levels and different funding curves. And it actually, unfortunately, accurately predicts that if you fund fusion below a certain level, even if you're funding it continually you'll never get to. An actual useful fusion source because you'll never have enough money to build these, these demonstrator missions. And so in a way it's sort of predicts the future. This, this document is super impressive. If you haven't seen it you should absolutely check it out there. There are links in the show notes and it's sort of, one of the reasons I wanted to talk to Dr. Dean is because this, this document. Is one of the pieces of evidence behind my hypothesis. That to some extent, program design and program management for advanced technologies is a bit of a lost art. And so I wanted to learn more about how he thought about it and built [00:03:00] it. So without further ado, here's my conversation with Steven Dean. To start off, what was the context of creating the fusion plan? Well, I guess I would have to say that it started a few years earlier in a sense that in 1972 the I was in the fusion office and in the atomic energy commission and the office of men and mission management and budget at the white house put out instructions to, I guess, all the agencies that they should prepare an analysis of their programs under a system, they called management by objectives. And this was some, this was a formalism that was, had a certain amount of popularity at that time. And I was asked to prepare something on the fusion program as a part of the agency, doing this for all of its programs. And [00:04:00] in doing that I looked at our program and I Laid out a map basically that showed the different parts of the program on a map like a roadmap and what the timelines might be and what the functions of those of facilities would be. And when the decisions might be and what decisions would work into into, into what, and that was never published in, in a report, but it w except internally, but the map itself was published and widely distributed. And I have it on my wall and it's in my book. So that was the first, my first venture into. Into doing something that resembled plan, it was

Eli Dourado on how the sausage of technology policy is made, the relationship between total factor productivity and technological progress, airships, and more. Eli is an economist, regulatory hacker, and a senior research fellow at the Center for Growth and Opportunity at Utah State University. In the past, he was the head of global policy at Boom Supersonic where he navigated the thicket of regulations on supersonic flight. Before that, he directed the technology policy program at the Mercatus Center at George Mason University.. Eli's Website Eli on Twitter Transcript audio_only [00:00:00] In this conversation, Eli Durado. And I talk about how the sausage of technology policy has made the relationship between total factor productivity and technological progress, airships, and more Eli is an economist regulatory, hacker, and senior research fellow at the center for growth and opportunity at Utah state university. In the past, he was the head of global policy at boom supersonic, [00:01:00] where he navigated the thicket of regulations on superstar. Before that he directed the technology policy program at the Mercatus center at George Mason university. I wanted to talk to Eli because it feels like there's a gap between the people who understand how technology works and the people who understand how the government works. And Isla is one of those rare folks who understands both. So without further ado my conversation with Eli Dorado. So just jump directly into it. When you were on a policy team, what do you actually do? Well that depends on which policy team you're on. Right. So, so in my career you mean, do you mean the, in sort of like the, the public policy or like the research center think tanks kind of space or in, in, in a company because I've done both. Yeah, exactly. Oh, I didn't even realize that you do like that. It's like different things. So so like, I guess, like, let's start with [00:02:00] Boom. You're you're on a policy team at a technology company and. Yeah. Yeah. So when I, when I started at boom so we had a problem. Right. Which was like, we needed to know what landing and takeoff noise standard we could design too. Right. Like, so, so we needed to know like how loud the airplane could be. And how, how quiet it had to be. Right. And, and as a big trade off on, on aircraft performance depending on that. And so when I joined up with boom, like FAA had a, what's called a policy statement. Right. Which is, you know, some degree of binding, but not really right. Like that they had published back in 2008 that said, you know, we don't have standards for supersonic airplanes, but you know, like when we do create them they, you know, they're during the subsonic portion of flight, we anticipate the subsidy Arctic standards. Right. So, so for, [00:03:00] for, for landing and takeoff, which is like the big thing that we are concerned about, like that's all subsonic. So we, you know, so that sort of the FAA is like going in position was like, well, the subsonic standards apply to, to boom. And so I kind of like joined up in early 2017 and sort of my job was like, let's figure out a way for that, not to be the case. Right. And so it was, it was basically, you know, look at all the different look at the space of actors and try to figure out a way for that, not to be true. And so, and so that's like kind of what I did. I started, you know, started talking with Congress with FAA. I started figuring out what levers we could push, what, what what angles we could Work work with to ensure that that, that we have we've got to a different place, different answer in the end. And, and so the, like, so basically it's just like this completely bespoke process of [00:04:00] totally like, even trying to figure out like what the constraints you're under are. Exactly. Right. So, so yeah, so it was, there's like a bunch of different, different aspects of that question, right? So there will you know, there's, there is statute, you know, congressional laws passed by Congress that had a bearing on the answer to that question that I went back to like the 1970s. And before there w you know, there was the FAA policy statement. There was, of course the FAA team, which you had to develop, you know you know, relationships with and, and, and, and sort of work with you have the industry association, right. That we remember of that Had different companies, you know, in addition, you know, in addition to boom, there, there were a bunch of other companies Ariane, which is no longer operating. We had Gulf stream, which no longer has a supersonic program. Or actually they didn't Edward admitted to having it announced really dead. They, you know, there was, you know, GE and rolls Royce. And so you had all these companies like coming together, you know, sort of under the, [00:05:00] under the watchful eye of Boeing, of course also. And, and so like the industry association had to have a position on things, and then you had like the internati

In this conversation I talk to the Amazing Arati Prabhakar about using Solutions R&D to tackle big societal problems, gaps in the innovation ecosystem, DARPA, and more. Arati's career has covered almost every corner of the innovation ecosystem - she's done basically every role at - DARPA she was a program manager, started their Microelectronics Technology Office, and several years later returned to server as its Director. She was also the director of the National Institute of Standards and Technology and was a venture capitalist at US venture partners. Now she's launching Actuate - a non-profit leveraging the ARPA model to go after some of the biggest problems in American society. Links Actuate Website In the Realm of the Barely Feasible - Arati's Article about Actuate and Solutions R&D Arati on Wikipedia Transcript [00:00:00] welcome to idea machines. I'm your host and Reinhart. And this podcast is a deep dive into the systems and people that bring innovations from glimmers in someone's eye, all the way to tools, processes, and ideas that can shift paradigms. We see these systems outputs everywhere, but what's inside the black boxes with guests. I dig below the surface into crucial, but often unspoken questions. To explore themes of how we enable innovations today and how we could do it better tomorrow. In this conversation, I talked to the amazing RFE provoca about using solutions R and D tackle, big societal problems, gaps in the innovation ecosystem, DARPA and more. Are these career has covered almost every corner of the innovation ecosystem. She's done almost every job at DARPA where she was a program manager, started their micro electronics technology office. And several years later returned serve as their [00:01:00] director. She was also the director at the national Institute of standards and technology and a venture capitalist at us venture partners. Now she's launching actuate a nonprofit leveraging the ARPA model to go after some of the biggest problems in American society. Hope you enjoy my conversation with Arthur. Provoca. I'd love to start off and sort of frame this for everybody is with a quote from your article, which, which everybody should read and which I will link to in the show notes. You say yet, we lack a systemic understanding of how to nurture the sort of rich ecosystem we need to confront the societal changes facing us. Now over 75 years, the federal government has dramatically increased supportive research and universities and national labs have built layers of incentives and deep culture for the research role. Companies have honed their ability to develop products in markets, shifting away from doing their own fundamental research in established industries, American venture capital and entrepreneurship have supercharged the startup pathway for commercialization in some [00:02:00] sectors, but we haven't yet put enough energy into understanding the bigger space where policy finance and the market meet to scale component ideas into the kind of deep and wide innovations that can solve big previously intractable problems in society. These sorts of problems, aren't aligned to tangible market opportunities or to the missions of established government R and D organizations today, the philanthropic sector can play a pivotal role by taking the early risk of trying new methods for R and D and developing initial examples that governments and markets can adopt and ramp up the hypothesis behind actuate is that solutions R and D can be a starting place for catalyzing the necessary change in the nation's innovation ecosystem. And so with that, with those, I think I want to test it in a nutshell exactly like that. So can we start with how do you see solutions R and D as being different from other R D and, and sort of coupled with that? How is actuate different from other non-profits. Yeah, I think [00:03:00] that's, that's one of the important threads in this tapestry that we want to develop. So solutions R and D let's see. I think those of us who live in the world of R and D and innovation are very familiar with basic research. That that is about new knowledge, new exploration, but it's designed all the incentives, all the funding and the structures are designed to have that end with publishing papers. And then on the other hand, there's. But the whole machinery that turns an advance into, you know, takes a technological advance or a research advance and turns it into the changes that we want in society that could be new products and services. It could be new policies, it could be new practices and that implementation machinery. The market companies, policymaking, what individuals choose to do pilot practices. I think we understand that. And there are places where the, you know, things just move from basic research over into actual [00:04:00] implementation. But in fact, there are, there are a lot of places where that doesn't happen, seamlessly and solutions, R and D is this weird thing in the

In this conversation I talk to Ilan Gur about what it really means for technology to "escape the lab", the power of context to shape the usefulness of research, the inadequacies of current institutional structures, how activate helps technology escape the lab *by* changing people's context, and more. Ilan is the CEO and founder of Activate, which is a nonprofit that runs a fellowship enabling scientists to spend two years embedded in research institutions to mature technology from a concept to a first product. In the past, he has also served as a program director at ARPA-E and was a cofounder of Seeo, where he commercial new high-density battery technology. Links Activate Ilan on Twitter Ilan on My Climate Journey Podcast Transcript In the past, we've talked about the, how the whole process of really turning hardcore scientific research into products that have an impact on people's lives is fairly abstract to people outside of the system. Since you've both walked the path and now help other people do the same, let's round the conversation. would you go into detail on what the actual actions you need to take to go from say, being a graduate student who just published a paper on a promising battery technology to an improved battery in a car. That's that's a great place to start. let me try and answer that from a few different dimensions. I'll, I'll start by answering it, just from an anecdote about my personal experience, which I've shared in other places, but, you know, I basically. Went into my PhD program because I felt like the field I was studying material scientists, material science could, be the biggest way to make a big impact on climate change by basically taking new science and turning it into the next generation of all the technologies. We need to have a sustainable economy. And, I was working in nanotechnology, joined. Kind of the world, the best research group in the world that that was working on how nano materials could improve solar cells. and this is before the, the enormous solar market that exists today exists. There was a sense at the time that, you know, we needed a completely new generation of technology to make solar ubiquitous and cost effective. And so, you know, we had this great mantra around how we were going to print solar cells like newspapers, using these small colloidal nano, semiconductors. and the research was phenomenal. we were driven by the fact that what I like to say is, you know, we wrote a science paper where the first paragraph, like any, talked about how the research was going to change the world. And it wasn't until I randomly got connected with some business school folks at Berkeley, where I was doing my PhD. and they actually. It didn't take long. they put me through just a few cycles of digging one level deeper into, how solar cells were actually made, how they were sold, what determined their, their costs and the cost of energy they produce. and I ended up, you know, over the course of a few weeks with a spreadsheet that I still have somewhere, which told me that. If we hit all of our targets and our research in terms of what we thought could change the world. we would end up with a solar cell where even if you gave it away for free, it couldn't compete with the existing state of the art Silicon solar cells at the time. and it was a really. Simple idea, which was, we were making dirt cheap solar cells, but they probably wouldn't last very long. And we didn't think that was such a big deal. You just print some more. and yet, certainly at the time, and it's still true. It's such a, such a predominant amount of the cost of solar energy came from the balance of systems and installations. And I bring up the story because, for me, it was a tipping point. We had so much excitement about our research. It was even published in Forbes, you know, so a business magazine, and. It just showed how it showed, how easy it was to think you were doing something productive and successful. I it's not that I, I, I was in academia, but the reason I was there was to try and get something productive that could turn into a product. Right. And I had missed the boat so much, even with that intention. and so that was a shock to me. And so. That was kind of the first lesson around how, you know, institutions matter and incentives matter. but what I ended up doing was then leaving academia and jumping into an early stage startup, which was an amazing vehicle to think about how this transition happens and, you know, basically the learning there, and, This is what we now, you know, this is a lot of what we now indoctrinate and try and help people understand in the fellowship we run, was that, you know, the depth and multitude of elements that determine whether a technology can actually make it from the research stage to a product in the market. You know, first of all, you know, the idea is like, you know, the easy part in some regard. but yeah. You know, the number of levels deeper, you have t

In this conversation I talk to Luke Constable about the complicated tapestry of finance, funding projects, incentives, organizational and legal structures, social technologies, and more. Luke is the founder of the hedge fund Lampa Capital and publishes a widely-read newsletter full of fascinating deep dives. He's also trained as a lawyer and historian so he looks at the world with a fairly unique set of lenses. Disclaimer: nothing Luke says is an offer to buy or sell a security or to make an investment Links Luke on Twitter Lampa Capital Theory of Investment Value (John Burr Williams) 1,000 True Fans (Kevin Kelly) Quantum Country Patreon Lampa Capital's Open Questions The Empire of Value (André Orléan) Who Gets What and Why (Alvin Roth) The Mystery of Capital (Hernando de Soto) I, Pencil (Leonard Read) The Crime of Reason (Robert Laughlin) Andrew Lo's papers Transcript 0:01:05 BR: So if technology creates a lot of wealth, why does it feel like most people in finance are hesitant to invest in technology? 0:01:19 Luke Constable: So that's an interesting place to start. I think you have to understand, no one invests in technology. If you think about investors, investors invest in businesses that use technology, and so that's probably the first frame I would use. Investors aren't hesitant to invest in technology, investors never invest in technology. What investors do is they invest in these products that are going to generate cash flow streams, and so that's sort of the first thing. And then the second thing is, a lot of the technologies that you and I think about, they seem obvious at a macro scale, where you take a high level view and you say, "Well, it would be so much better if we had a blank sheet of paper," and I said, "We should do X." 0:02:10 LC: For instance, you could make an argument about housing technology in San Francisco, and you could say, "All of these houses built in SF, they're old Victorians, they don't really have washing machines and laundry machines, you could probably change the structural engineering, probably build them higher". And if you look at them and said, "Oh, I have a better prefab housing technology," or "I have a better way to do it," you'd miss the point, which is just because you've invented the physics, and this is the other thing, you actually have to sell it into a market. You have to work within the market, and so that's usually where I see a lot of the interesting technical products fall down. 0:02:53 BR: So the thing that I want to poke at in the assertion that people invest in businesses is that people invest in things that are not businesses as well, people invest in gold, in currencies and other, I guess, assets would be the high level thing, and so I guess the question is why isn't technology itself an asset, and there's probably a very obvious answer to this, I just... 0:03:25 LC: Sure, so let's take a step back and talk about the various asset classes, there's sort of a couple of ways to break them down. 0:03:32 BR: Okay. 0:03:33 LC: One way people do this is they'll say there are real assets, these are things like real estate, some people put commodities in there, and then there are sort of these yield assets, these are debt that is putting out a cash flow stream, and then you have equities, and there's some argument that cryptocurrency is sort of its own asset class, and then currencies might be their own asset class too. And what you'll quickly find is these things kind of blend together. A lot of them are different ways of financing sort of the same project. And then you have the ones that are just traded for their own sake. So there's sort of two questions you're asking, the first is, why isn't "technology" the same as like gold or silver or real estate, for instance? And so there's a use value to all of those commodities, and that's why they have value, and that actually is a cash flow stream, we actually do use gold, we do use silver, and that's how that works. 0:04:43 LC: But if you think about what's valuable, there's sort of something that's value... And I should have started with this. When you think about what value is, there's value in exchange and then there's value in use. So the value in exchange ones, these are often, you could argue, cryptocurrency or a lot of currencies, gold is actually usually thought of as a medium of exchange, that actually is valuable for cash flow purposes just probably not in the ways that you think. So what happens with these currencies and these stores of value is they sort of become Schelling points where I just know there are enough people transacting in that thing that I can find the liquidity, I can actually go convert to cash, and I can go basically get that cash when I need it. That actually is a cash flow need. It's just not often thought of that way. 0:05:40 LC: Now, liquidity is really valuable because you might be invested in the best business of all time, and it might have a very, very, very high net prese

In this conversation I talk to Donald Braben about his venture research initiative, peer review, and enabling the 21st century equivalents of Max Planck. Donald has been a staunch advocate of reforming how we fund and evaluate research for decades. From 1980 to 1990 he ran BP's venture research program, where he had a chance to put his ideas into practice. Considering the fact that the program cost two million pounds per year and enabled research that both led to at least one Nobel prize and a centi-million dollar company, I would say the program was a success. Despite that, it was shut down in 1990. Most of our conversation centers heavily around his book "Scientific Freedom" which I suspect you would enjoy if you're listening to this podcast. Links Scientific Freedom Transcript audio_only [00:00:00] This conversation. I talked to Donald breathing about his venture research initiative, peer review, and enabling the 21st century equivalent of max Planck. Donald has been a staunch advocate for forming how we fund and evaluate research for decades. From 1980 to 1990, he ran BP's venture research program. Where he had a chance to put his ideas into practice. [00:01:00] Considering the fact that the program costs about 2 million pounds per year and enabled research, that book led to at least one Nobel prize and to send a million dollar company. I would say the program was success, despite that it was shut down in 1990. Most of our conversations centers heavily around his book, scientific freedom, which just came out from straight press. And I suspect that you would enjoy if you're listening to this podcast. So here's my conversation with Donald Raven. would you explain, in your own words, the concept of a punk club and why it's really well, it's just my name for the, for the, outstanding scientists of the 20th century, you know, starting with max blank, who looked at thermodynamics, and it took him 20 years to reach his conclusions, that, that matter was, was quantized. You know, and that, and, he developed quantum mechanics, that was followed by Einstein and Rutherford and, and, and a [00:02:00] whole host of scientists. And I've called, in order to be, succinct Coley's they, these 500 or so scientists who dominated the 20th century, the plank club. So I don't have to keep saying Einstein rather for that second. I said, and it's, it's an easy shorthand. Right. And so, do you think that like, well, there's a raging debate about whether the existence of the plank club was due to sort of like the time and place and the, the things that could be discovered in physics in the first half of the 20th century versus. Sort of a more or more structural argument. Do you, where do you really come down on that? The existence of the plank club? [00:03:00] W well, like, yeah, so like, I guess, I guess it's, tied to sort of like this, but the question of like, like almost like, yeah. Are you asking, will there be a 20th century, 21st century playing club? Do you think, do you think it's possible? Like, it's sort of like now right now. No, it's not. because, peer review forbids it, in the early parts of the 20th century, then scientists did not have to deal with, did not necessarily have to deal with peer review. that is the opinions of the, of the expert of the few expert colleagues. they just got on, on, Edgar to university and had a university position, which was as difficult then as it is now to get. But once you got a university position in the first part up to about 1970, then you could do then providing your requirements were modest, Varney. You didn't [00:04:00] need, you know, huge amounts of money. Say. You could do anything you wanted and, you didn't have to worry about your, your peers opinions. I mean, you did in your department when people were saying, Oh, he's mad. You know, and he's looking at this, that, and the other, you could get on with it. You didn't have to take too much attention. We pay too much attention to what they were doing, but now in the 21st century, consensus dominates everything. And, it is a serious, serious problem. Yeah. So I, I seriously believe that keeps me what keeps me going is that it is possible for there to be a plane club in the 21st century. It is possible, but right now it won't take, it won't happen. I mean, re there's been reams written on peer review, absolute huge, literature. and the, but, but most of it seems to have been written by, by people who at least favor the status [00:05:00] quo. And so they conclude that peer review is great, except perhaps for multidisciplinary research, which ma, which might cause problems. This is the establishment view. And so they take steps to try to ease the progress of multidisciplinary research, but still using peer review. Now. Multidisciplinary research is essentially is, is absolutely essential to venture research. I mean, because what they are doing, what every venture researchers, the researcher is doing is to look at the universe. a

A conversation with Adam Marblestone about his new project - Focused Research Organizations. Focused Research Organizations (FROs) are a new initiative that Adam is working on to address gaps in current institutional structures. You can read more about them in this white paper that Adam released with Sam Rodriques. Links FRO Whitepaper Adam on Twitter Adam's Website Transcript [00:00:00] In this conversation, I talked to Adam marble stone about focused research organizations. What are focused research organizations you may ask. It's a good question. Because as of this recording, they don't exist yet. There are new initiatives that Adam is working on to address gaps. In current institutional structures, you can read more about them in the white paper that Adam released recently with San Brad regens. I'll put them in the show notes. Uh, [00:01:00] just a housekeeping note. We talk about F borrows a lot, and that's just the abbreviation for focus, research organizations. just to start off, in case listeners have created a grave error and not yet read the white paper to explain what an fro is. Sure. so an fro is stands for focus research organization. the idea is, is really fundamentally, very simple and maybe we'll get into it. On this chat of why, why it sounds so trivial. And yet isn't completely trivial in our current, system of research structures, but an fro is simply a special purpose organization to pursue a problem defined problem over us over a finite period of time. Irrespective of, any financial gain, like in a startup and, and separate from any existing, academic structure or existing national lab or things [00:02:00] like that. It's just a special purpose organization to solve, a research and development problem. Got it. And so the, you go much more depth in the paper, so I encourage everybody to go read that. I'm actually also really interested in what's what's sort of the backstory that led to this initiative. Yeah. it's kind of, there's kind of a long story, I think for each of us. And I would be curious your, a backstory of how, how you got involved in, in thinking about this as well. And, but I can tell you in my personal experience, I had been spending a number of years, working on neuroscience and technologies related to neuroscience. And the brain is sort of a particularly hard a technology problem in a number of ways. where I think I ran up against our existing research structures. in addition to just my own abilities and [00:03:00] everything, but, but I think, I think I ran up against some structural issues too, in, in dealing with, the brain. So, so basically one thing we want to do, is to map is make a map of the brain. and to do that in a, in a scalable high-speed. Way w what does it mean to have a map of the brain? Like what, what would, what would I see if I was looking at this map? Yeah, well, we could, we could take this example of a mouse brain, for example. just, just, just for instance, so that there's a few things you want to know. You want to know how the individual neurons are connected to each other often through synopsis, but also through some other types of connections called gap junctions. And there are many different kinds of synopsis. and there are many different kinds of neurons and, There's also this incredibly multi-scale nature of this problem where a neuron, you know, it's, it's axon, it's wire that it sends out can shrink down to like a hundred nanometers in [00:04:00] thickness or less. but it can also go over maybe centimeter long, or, you know, if you're talking about, you know, the neurons that go down your spinal cord could be meter long, neurons. so this incredibly multi-scale it poses. Even if irrespective of other problems like brain, computer interfacing or real time communication or so on, it just poses really severe technological challenges, to be able to make the neurons visible and distinguishable. and to do it in a way where, you can use microscopy, two image at a high speed while still preserving all of that information that you need, like which molecules are aware in which neuron are we even looking at right now? So I think, there's a few different ways to approach that technologically one, one is with. The more mature technology is called the electron microscope, electromicroscopy approach, where basically you look at just the membranes of the neurons at any given pixel sort of black or white [00:05:00] or gray scale, you know, is there a membrane present here or not? and then you have to stitch together images. Across this very large volume. but you have to, because you're just able to see which, which, which pixels have membrane or not. you have to image it very fine resolution to be able to then stitch that together later into a three D reconstruction and you're potentially missing some information about where the molecules are. And then there's some other more, less mature technologies that use optical microscopes and they use other technolo

Michael Filler and Matthew Realff discuss Fundamental Manufacturing Process innovations. We explore what they are, dig into historical examples, and consider how we might enable more of them to happen. Michael and Matthew are both professors at Georgia Tech and Michael also hosts an excellent podcast about nanotechnology called Nanovation. Our conversation centers around their paper Fundamental Manufacturing Process Innovation Changes the World. If you're in front of a screen while you're listening to this, you might want to pull up the paper to look at the pictures. Key Takeaways Sometimes you need to go down to go back up The interplay between processes and paradigms is fascinating We need to spend more time hanging out in the valley of death Links Fundamental Manufacturing Process Innovation Changes the World(Medium)(SSRN) Michael on Twitter Matthew Realff's Website Michael Filler's Website Nanovation Podcast Topics - The need for the innovator to be near the process - Continuous to discrete shifts - Defining paradigms outlines what progress looks like - Easy to pay attention to artifacts, hard to pay attention - Hard to recreate processes - The 1000x rule of process innovations - Quality vs price improvements - Process innovation as a discipline - Need to take a performance hit to switch paradigms - How to enable more fundamental manufacturing process innovations Transcript [00:00:00] this conversation, I talked to Michael filler and Matthew Ralph about fundamental manufacturing process innovations. We explore what they are, dig into historical examples and consider how we might enable more of them to happen. Michael and Matthew are both professors at Georgia tech and Michael also hosts an excellent podcast about nanotechnology called innovation. Our conversation centered around their paper called fundamental [00:01:00] manufacturing process. Innovation changes the world, which I've looked to in the show notes and highly recommend the fact that they posted it on medium. In addition to more traditional methods, give you a hint that they think a bit outside the normal academic box. However, I actually recommend the PDF version on SSRN, which is not behind a paywall only because it has great pictures for each process that I found super helpful. If you're in front of a screen, while you're listening to this, I suspect that having them handy, it might enhance the conversation. And here we go. the, the place that I'd love to start is, to sort of give everybody a, get them used to both of your voices and sort of assign a personality, a personality to each of you. so if each of you would say a bit about yourselves, and the. The, the sort of key bit that I've loved you to say is to, to focus on something that you believe that many people in your discipline would sort [00:02:00] of cock an eyebrow at because clearly by publishing this piece on medi you sort of identify yourself as not run of the mill professors. Oh boy. Okay. So we're going to start juicy, real juicy. So I guess I'll go since I'm speaking, this is Mike filler speaking. Great to be here. so I've been a professor of chemical engineering at Georgia tech for a little over 10 years now. my research group works in nanoscale materials and device synthesis and scale up. So for say electronics applications, Yeah. I mean, this article, which we'll talk about emerged from, you know, can I say a frustration that I had around electronics really is where it started for me, at least, that. We have all this focus on new materials or new device physics or new circuit. And I know your listeners are probably thinking about morphic computing or quantum computing, and these are all very cool things, but it seemed to me [00:03:00] that we were entirely missing the process piece. The, how do we build computers? and, and, and circuitry. And, and so that's where this started for me was, starting to realize if we're not dealing with the process piece, that we're, we're missing a huge chunk of it. And I think one of the things is that people, people miss that where within working within the context of something developed 50 or 60 years ago, in many cases, and it's it's was really hidden to a lot of people. And so that, that was where I came at this. Great. All right. So, yeah, so I'm, also a professor of chemical and biomolecular engineering at Georgia tech. my background is actually in process systems engineering. And, if you go back to the late 1960s, early 1970s, actually frankly, before I was a much more than in shorts, there was a, that was a real push towards. The role of process systems engineering in [00:04:00] chemical engineering in it really arose with the, with the advent of computing and the way that computing could be used to help in chemical engineering. And then slowly over time, the, the role of process systems engineering has become, I think, marginalized within the chemical engineering community, it's gone much over towards. What I call science and engin