Tryptophan, Microtubulus, & Mitosis
From the Spectrum: Finding Superpowers with Autism · Ryan Sumner
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Show Notes
This episode explores the critical role of tryptophan, an aromatic amino acid, in forming tubulin—the key protein building microtubules, which act as cellular "train tracks" for structure and movement. We delve into how microtubules drive mitosis, the process of cell division essential for growth and repair, and discuss tryptophan’s unique biochemical significance, including its single codon (UGG) and contributions to DNA methylation.
We connect these cellular mechanisms to Autism, examining how microtubule disruptions may affect neuron proliferation and migration during prenatal development, potentially leading to sensory processing issues and altered connectivity. The episode highlights the intricate dance of cells in neural tube formation and emphasizes the need for deeper research into these upstream processes to uncover Autism’s developmental roots.
YT video of tryptophan and microtubules https://youtu.be/AY6GmS_AePk?si=K_ZTy5RjLGkm1hGd
Inner Cell Life video https://youtu.be/RrS2uROUjK4?si=DCHs927yteOZ00dW
See Stuart Hameroff, Martin Picard, Michael Levin, Jack Kruse
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00:00 Daylight Computer Company, use "autism" for $25 discount
04:22 tryptophan, aromatic amino acid, microtubules, mitosis; human biology, autism
04:44 tryptophan, UGG codon, methionine, SAM, MTHFR, folate, DNA methylation; upstream biology, RNA, DNA
06:04 microtubules, train tracks, mitosis, cell division, spindle, DNA separation; skin repair
06:55 tryptophan, tubulin, microtubules, mitosis, intracellular transport, cell shape; Autism research, upstream processes
9:25 Chroma Light Devices- Lights Designed for Humans, use "autism" for 10% discount
12:27 tryptophan fluorescence, mitosis, prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis; microtubules, chromosome movement, cell division, tissue repair
15:58 mitosis, neural tube, embryonic development, neuron proliferation, migration; Autism, brain size, connectivity
20:33 sensory processing, hyperconnectivity, synaptic pruning, microtubules; Autism, sensory sensitivities, cortical connections
25:06 excitation-inhibition imbalance, microtubules, environmental toxins, light exposure, fertilization, blastocyst; Autism, prenatal development, cell polarity
31:09 microtubules, neural tube, gastrulation, neurogenesis, synaptogenesis, ectoderm, mesoderm, endoderm; Autism, cell migration,
37:18 outro, reviews
Hopp: https://www.hopp.bio/fromthespectrum
YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA
email: [email protected]