From the Spectrum: Finding Superpowers with Autism

In this episode, we explore typical topics with Autism research and try to understand the purpose. Autism research is confounding, and maybe, lacks direction. We offer a research suggestion based on the most plausible cause of Autism- the new modern day environmental factor- Artificial Light. Remember, Autism just shows up, so it makes sense to send the mother and father back to an environment pre-Autism.Quantum Biology https://www.patreon.com/DrJackKruse/postsPhotobiological Implications of Folate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862485/B9 (folate) and B12 (cobalamin) are Photoreceptors, too.0:00 Autism Research Direction and missing the beginning; Is it Click-Bait?; Confounding3:30 Changes in Light and the Full Spectrum; the number of Genes involved with Autism Research5:07 Genetic Variants, Copy Number, Duplications, Deletions7:04 Gene-Envrionment Interaction; MTHFR; Methylation, Myelin13:03 Brain Connectivity and Neurobiology13:55 Socio-Environmental/Socioeconomic; Robert Sapolsky14:25 Early Diagnosis and Bio-markers14:47 Comorbid Conditions16:05 Personalized Interventions16:27 Medications and the PROFIT MILL18:36 Today's Purpose; Parental Melanin, Artificial Light, and nnEMF19:30 Research Idea with 3 Groups and Returning the Environment before Autism magically shows up25:17 Shift-Work Warning26:20 Back to Autism; Amish29:07 Reviews/Ratings, Contact InfoX: https://twitter.com/rps47586Hopp: hopp.bio/fromthespectrumemail: [email protected]

In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496Su study: https://www.nature.com/articles/s41564-024-01739-1Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/posts(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems(6:22) POMC; HPA; Stress example(8:19) Common Autism problems in the GI(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation(14:09) Melanin/POMC; Clock-Timing; Omentum(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut(19:04) Vitamin D Receptors and more Clock-Timing(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids(24:33) Avoiding UV Light implications(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD(38:27) Reviews/Ratings and Contact InfoX: https://x.com/rps47586Email: [email protected]

In this episode, we explore Autism developing in the embryo. We will review a couple Scientific papers discussing specific time frames of development within the embryo based on each trimester and specific cellular abnormal processes occurring. We will connect previous biological and environmental components and how it influences the creation of Autism and previous episodes of From the Spectrum podcast.Remember in the Cause of Autism episode- Light, Water, Magnetism, Periodic Elements, Vitamins, and Proteins because they are involved. During the episode, we review risk-genes and how this could be the wrong direction for Autism research. As a counter, I provide where research and funding needs to focus- pregnancy.Cause of Autism https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496Eric Courchesne https://profiles.ucsd.edu/eric.courchesnePrenatal Origins of ASD: The When, What, and How of ASD Development https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(20)30051-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223620300515%3Fshowall%3DtrueThe ASD Living Biology: from cell proliferation to clinical phenotype https://www.nature.com/articles/s41380-018-0056-yLeukocytes and Melanin Pigmentation https://core.ac.uk/download/pdf/81931995.pdfmTOR and PTEN https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743803/Cancer Drug for "Autism" https://neurosciencenews.com/asd-cognition-cancer-pharmacology-26481/0:00 Autism and the Embryo; Review of previous developmental milestones, and the processes and "ingredients" used in our Biology5:45 Cellular processes; ASD Living Biology; becoming the complex living organism8:17 1st Trimester: Proliferation, neurogenesis, migration8:46 2nd Trimester: Neurite overgrowth, synaptogenesis and synaptic function9:12 3rd Trimester: Neural networks9:33 Epoch 1 and 213:04 Scientific Literature; risk-genes; send research and funding to pregnancy17:57 Abnormal brain development in the embryo21:39 Excitation and the risk-genes and consequences to the Nervous System24:36 Be cautious of research direction; MEDICATION and MEDICAL PARADIGM RANT29:32 Connecting Light and Abnormal Development across the Body- Example Melanin and Leukocytes33:12 Recap on the Past 3 episodes36:00 Reviews/Ratings and Contact InfoX: https://twitter.com/rps47586Facebook: https://www.facebook.com/fromthespectrum.podcastEmail: [email protected]

In this episode, we explore some critical dates and understanding of Autism. We will time travel from 1911 to 2024 with a goal of understanding why the sharp increase in Autism diagnosis of late. We review the closeness of schizophrenia and the separation from schizophrenia. In addition, we will review Autism becoming a separate diagnosis in the DSMs from the 1980s and review the closeness of Vaccines and Assessment Standardization that parallels this time. Hopefully, some consideration about the rates of Autism are presented.Top Revenue Business Types- Not good. https://www.ibisworld.com/united-states/industry-trends/biggest-industries-by-revenue/Bayh-Dole Act https://www.govinfo.gov/content/pkg/USCODE-2011-title35/html/USCODE-2011-title35-partII-chap18.htmHow Autism became Autism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757918/#bibr56-0952695113484320Eugon Bleuler DEMENTIA PRAECOX OR THE GROUP OF SCHIZOPHRENIAS https://philpapers.org/archive/BLEDPO-2.pdfDr. Catherine Lord https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000659246090(0:00) Intro, Classifications, Symptoms, Schizophrenia, DSM, Assessments, Vaccines and Bayh-Dole Act(3:21) 1911; Twilight Peaks; Psychoanalysis; Eugon Bleuler; Early Autism(10:37) 1959- Separating from Schizophrenia; Generational Lineage; Visual Imagery; Communication Problems are noticed(14:21) The DSM and the Development of Autism Diagnosis(17:32) Assessments becoming Standardized(20:22) Vaccines and the Bayh-Dole Act of 1980; Vaccine Schedule and Centralized Medicine and Revenue(25:06) 1980s-2000 emergence of Diagnosis and Assessments; Rates of Autism and Explainations(30:03) Reviews/Ratings and Contact InfoX https://twitter.com/rps47586Facebook https://www.facebook.com/fromthespectrum.podcastEmail [email protected]

Autism just magically shows up."... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse(Start here) Regenerative Health with Dr. Max Gulhane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uADecentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXsTryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079revAutism and Melanin https://www.patreon.com/posts/quantum-45-837245670:00 Introduction & Framing Podcast blends science, personal experience, and opinion to explain autism. Autism “appeared” around 1938 (Kanner/Asperger), with rates rising sharply. Parallels to post-1880s conditions (Alzheimer’s 1906, diabetes, obesity, ADHD) linked to electrification. 5:30 Central Thesis: Light as the Common Environmental Factor Light is the key environmental change. Pre-1880s: sunlight/fire (red/IR-rich). Modern: blue-heavy artificial light. Disrupts vitamin A/B/D, amino acids, water, melanin, melanopsin, POMC. 12:00 Cellular & Mitochondrial Mechanisms Blue light dehydrates cells, disrupts TCA cycle and ATP production. Mitochondria need red/NIR for oxygen-to-water conversion; blue causes hypoxia/stress. Universal cellular vulnerability explains issues without added toxins.19:00 Neuroplasticity & Autism as Adaptation Autism as extreme neuroplasticity adapting to light stress, like blind individuals repurposing visual cortex. 22:00 Lifespan Symmetry: Autism Dementia Autism and dementia rates mirror across lifespan. Both show early retinal damage. Artificial light at night exploded post-1940s, enabling 24/7 life at biological cost.26:00 Light Spectra Compared Sun: 250–3100 nm, 43–47% red/IR. Incandescent/fire: warm/red-dominant. LEDs: blue peak (460–480 nm). Indoor dim vs. outdoor bright. Vitamin D inverse with autism; lower rates near equator.31:00 Wavelength-Specific Benefits 37:00 The Unsung Hero Melanin absorbs all light to power biology and protect vs. stress/toxins. Neuromelanin links to Parkinson’s; autism raises Parkinson’s risk 3x. 48:00 Tryptophan → Serotonin → Melatonin Pipeline UVB activates tryptophan → serotonin → melatonin (95% mitochondrial). Blue light causes radicals, disrupts cells. Serotonin modulates development, sensory, gut58:00 Rapid brain growth needs optimal light. Autism disrupts cell migration, speech/motor/sensory. GABA switch vulnerable.1:07:00 B-Vitamins & UVB-dependent; blue disrupts folate/B12 for DNA methylation. 1:14:00 Autism rise coincides with electrification. More sunlight in pregnancy could reduce riskX: https://twitter.com/rps47586Email: [email protected]

In this episode, we discuss Autism with Dr. Leanna Hernandez. Dr. Hernandez is an Assistant Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA and director of the Hernandez Lab. She is a member of UCLA’s Center for Autism Research and Treatment, Center for Neurobehavioral Genetics, and the Brain Research Institute, and serves as Co-Director of the Genetics, Genomics, and Informatics Core for UCLA’s Intellectual and Developmental Disabilities Research Center.Hernandez Lab https://www.hernandezlabucla.orgAdditive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism https://www.nature.com/articles/mp2016209Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity https://www.nature.com/articles/s41398-020-0750-9Oxytocin and Vasopressin and the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273 https://www.youtube.com/watch?v=DAtmC-s1_e0(0:00) Intro; Dr. Leanna Hernandez(2:24) Autistic Phenotypes(4:13) Dr. Hernandez education journey into Autism and the Hernandez Lab(9:03) 2017 Paper Oxytocin Receptor Gene, Common Genetic Variance, Single Nucleotide Polymorphisms (SNP), and Reward and Social Processing and the Nucleus Accumbens (NAc)(15:10) Differences in Brain Connectivity between Autistics and Non-Autistics(20:06) Social Cognition, Boy Bias in Autism; GENDAAR Consortium and Sex- and Diagnosis-Differences(21:48) GENDAAR(22:45) Boys versus Girls Connectivity involving the NAc with and without Autism(25:38) Different Connectivity correlated with Different ADOS scores for Repetitive Behaviors(26:35) Female Protective Effect for Autism; Camouflaging/Masking(30:19) The Assessment process for Girls and the Oxytocin Receptor Gene Sex Differences and Socialness and understanding the Boy Bias(32:48) Current Research and a Genome Wide approach and Polygenic Risk Scores(35:10) Oxytocin and Excitation/Inhibition(37:08) Sharing Information and Current Research(41:45) The Future of Autism Research(45:48) Reviews/Ratings and Contact Infoemail: [email protected]: https://twitter.com/rps47586Facebook: https://www.facebook.com/fromthespectrum.podcast

We expand on a critical network discussed in the Autism and Adaptive Responses episode. The biology that gives us Autism, gives us a condition the outside world is chaotic. The trade off is our inner world is comfortable. See criteria B.3. The Salience Network is used to determine what we send our attention to as we orient ourselves with the outside world. You can see this in Autism versus Non-Autism. Autistics orient to single objects or single interests more than multiple objects or interests. That's Criteria B of Autism- Restricted, Repetitive Interests, Behaviors, or Activities.In Autism, the Salience Network connects to different regions compared to Non-Autism, and this is shown at Six-Weeks-Old. And, this implicates our Social Attention and Social Motivation. Remember Hans Aspergers called the children "little professors" because Autism provides a path of Superpowers based on those fixated interests that are "abnormal in intensity or focus."Covered Here. Also, we prepare for another discussion with a leading scientist from UCLA.Study on Six-Week-Old https://www.nature.com/articles/s42003-024-06016-9GENDAAR https://pubmed.ncbi.nlm.nih.gov/34050743/(0:00) Intro; Human's Capacity to Think; the Salience Network and the NAc(2:56) Insula(4:47) Defining the Salience Network and Salience Detection; getting "hijacked" and metabolic bank account(7:42) the Biology that gives us Autism causes a Chaotic outside world(9:00) Returning to Six-week-olds and the Salience Network(10:28) The Prefrontal Cortex and Human Cortex quiets things so we can properly evaluate things(13:52) Salience Connections of six-week-olds; social attention at 3-12 months; Autistic traits at 12 months(17:40) Sex-and-Diagnosis Differences; GENDAAR study using 8-17 year olds; Salience Network and Sensorimotor and Repetitive Behaviors(20:47) Second Key Finding and possible cause of Boys Bias with Autism(21:30) The Nucleus Accumbens- Reward Hub; Two Parts; shell and core(25:20) Preparing for a future episode(30:27) Reviews/Ratings and Contact InfoFacebook https://www.facebook.com/fromthespectrum.podcastEmail: [email protected]

In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3DtrueMagnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysishttps://pubmed.ncbi.nlm.nih.gov/33400920/Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light(8:58) Magnocellular and Parvocellular(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions(22:20) Scientific Literatures(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing(30:07) Oxytocin and Dopamine(31:08) Dopamine Receptors(31:37) GABA(33:57) Intranasal Oxytocin(36:08) Take aways from Intranasal Literature(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)email: [email protected]

In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment.Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement and being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical and Educational Systems.Dr. Catherine Lord:https://www.semel.ucla.edu/autism/team/catherine-lord-phdhttps://childmind.org/bio/catherine-lord-phd/https://labs.dgsom.ucla.edu/lord/pages/our_teamThe Lancet Commission https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01541-5/abstractThe Lancet https://pubmed.ncbi.nlm.nih.gov/30078460/Nature Reviews Disease Primers https://pubmed.ncbi.nlm.nih.gov/31949163/Autism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638https://music.amazon.com/podcasts/d948fecc-8cfa-4203-8493-a12d2c9c92ed/episodes/bf7ce843-0dd2-4fe8-b800-82ea9cace96d/from-the-spectrum-finding-superpowers-with-autism-autism-and-educationThe mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/(0:00) Intro(3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum(11:25) The Evolution of Autism Assessment and Discussion on the ADI and ADOS- from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments(16:36) Gaps in the Autism Assessment(23:15) The Challenges with Understanding the Spectrum of Autism(29:32) Updates on the Lancet Commission and Profound Autism(35:19) Barriers with Autism and the Medical Field(39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, and Subject Switching (understand B3: Fixated Interests)(44:25) The Future of Autism and Helping Autistics Across the Life Span(51:03) Reviews/Ratings and Contact Infoemail: [email protected]

In this episode, we explore three regions associated with social awareness- the medial Prefrontal Cortex, the Anterior Cingulate Cortex, and the Insula. We review the functions of each, the interactions between each region, and the inputs and bi-directional connections to some crucial areas of the brain. In large part, we will review adaptive responses and cover some scientific literature on these regions and the implications to Autism.https://molecularautism.biomedcentral.com/articles/10.1186/s13229-024-00593-6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354837/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766703/#:~:text=Schematic%20structure%20of%20different%20regions,and%20infralimbic%20cortex%20(IL).https://www.cell.com/neuron/fulltext/S0896-6273(12)01108-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627312011087%3Fshowall%3Dtruehttps://www.nature.com/articles/s42003-024-06016-9https://www.sciencedirect.com/science/article/pii/S0149763409000815?via%3Dihub#aep-section-id15https://www.tandfonline.com/doi/full/10.1080/17470919.2023.2242095https://www.sciencedirect.com/science/article/abs/pii/S0006322308011578(0:00) Intro; mPFC, ACC, and Insula(3:26) mPFC, Excitation / Inhibition; CNTNAP2, SHANK3, Neuroligin, and PTEN(7:42) Functions of mPFC and a primary dive into Adaptive Responses; Neuromodulators(13:52) ACC(15:23) the mPFC and ACC lead the way(19:29) Scientific Studies on Theory of Mind Task and Sensory Processing(21:52) Insula(26:49) Scientific Study: Eye Gaze, Social Attention, Social Cognition, Observational Learning(30:11) Social and Nonsocial Studies- different areas for Autistics versus Non-Autistic(32:38) A study using 6-week-old Infants, attentional biases and sensorimotor and different brain areas(35:05) Wrap Upemail: [email protected]

In this episode, we discuss biology of anxiety, responses from anxiety, and common situations causing anxiety with Autism. The stress response system of the body is very finite and the nervous system reflexively responds based on what it knows. A few biological components of anxiety include the amygdala, bed nucleus of the stria terminalis (BNST), and the spine. Common responses to anxiety include avoidance, shifts in physiology, and valance, or how we feel about the situation. To end, we have a lengthy discussion on some common sources of anxiety. Biology and Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690364/Deisseroth on Anxiety https://www.youtube.com/watch?v=UtCeIefq_PMDeisseroth on Autism and Anxiety https://www.youtube.com/watch?v=4oiKOX2lCmEPhysiological Sighs https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00474-8Jack Feldman https://bioscience.ucla.edu/people/jack-feldman/David Spiegel https://med.stanford.edu/profiles/david-spiegelJoseph LeDoux https://as.nyu.edu/faculty/joseph-e-ledoux.html(0:00) Intro; Comorbid Tendency and the DSM(2:56) Anxiety's role(3:42) Biology and responses of Anxiety; Amygdala and Bed Nucleus of the Stria Terminalis; Avoidance, Physiology, Valance(7:48) Avoidance (Action)- Hypothalamus(9:11) Brief notes on Cortex(11:36) Back to the Hypothalamus(12:27) Physiology/Breathing (Body)- Parabrachial Nucleus; Physiological Sigh; Brainstem, Spine, and Body(17:48) Valance (Feelings)- Ventral Tegmental Area; direct or indirect exposure- it doesn't matter(20:00) Dopamine, Neuroplasticity, Side note on Testosterone, Multiple words have the same meaning(24:58) Common situations for Anxiety and Autism(35:58) Wrap Up, Reviews and Ratings, Contact Info

In this episode, we cover Autism and employment- some Superpowers and some Superdeficits. We discuss different types of work that are easier and fit our abilities and cover some challenges in the workplace. Some challenges include the social dynamic and being misunderstood, which are driving forces and sources of burnout and avoidance. Remember the metabolic "bank" account and the Excitation/Inhibition discussion. Brain Science and Sir Simon Baron-Cohen https://www.youtube.com/watch?v=gMxfq_QLuUUBrain Science Podcast https://www.youtube.com/@BrainSciencePodcastPattern Seekers by Sir Simon Baron-Cohen https://www.amazon.com/Pattern-Seekers-Autism-Drives-Invention/dp/1541647149Autistic Brain by Temple Grandin https://www.amazon.com/Autistic-Brain-Temple-Grandin/dp/0544227735(0:00) Intro; Clip of Sir Simon Baron-Cohen on Brain Science with Dr. Ginger Campbell; Society's trap and time perception(6:20) Autism and awareness; Do others see or understand our abilities(9:12) The applying process and the interview- we hate look at me; Superdeficits are easier to remember; Honesty and accuracy and Employers don't have an accurate comparison(12:39) Understanding the Autistic Brain(14:25) Autistic Traits - some Superpowers(21:20) Autistic Traits - some Superdeficits(28:43) Good and Bad: Perfectionism- a tough balance(30:42) Do things that you can do, you will do, and you love to do; The Nervous System just does; See Temple Grandin and Sir Simon Baron-Cohen on types of employment for different types of Autistic Brains(31:38) Reviews and Ratings; Contact Information

In this episode, we discuss Autism and Education. We explore some current condition within education and some personal experiences. Specifically, the school day is in complete conflict with Autism- both Criteria A and B. This is the primary factor with the challenges of Autism in Education. The classroom requires a Social Dynamic, a Speech and Language Dynamic, and Sensory-Processing Dynamic, which is 3 strikes against Autism. In addition, the subject switching throughout the school day complicates our path of learning- Our learning style prefers spending extended times on a single subject. Autism gives us the ability to be comfortable within ourselves and this accelerates our learning, our Superpowers. School and the world mostly requires the social communication and interaction.Antipsychotics https://www.marketresearchfuture.com/reports/antipsychotic-drugs-market-2784#:~:text=The%20antipsychotic%20drugs%20market%20size,period%20(2023%20%2D%202030).Pediatrician and Psychologists on the Medical Paradigm https://podcasts.apple.com/us/podcast/radically-genuine-podcast-with-dr-roger-mcfillin/id1573253801?i=1000624733618Autism and Education https://www.fhautism.com/shop/autism-and-education-the-way-i-see-it-what-parents-and-teachers-need-to-know/Thinking in Pictures https://www.grandin.com/inc/visual.thinking.htmlAutism and Intelligence and an Explanation https://www.youtube.com/watch?v=pxNg0xcadsM&t=316s(0:00) Intro; Autism and Education; Are Educators educated on Autism?; Biases from others towards the environment(7:00) The Prescription Era; Medication first Paradigm(10:32) The School Day- Conflicts with Criteria A and B; Limits a Capacity to Think; Underlying thoughts and feelings of agitation and frustration when learning;(13:15) Autism gives us the ability to be comfortable within ourselves; Are we like the so-called normal people, or not?(13:39) The Classroom- Social Dynamic, Speech and Language Dynamic, Sensory-Processing Dynamic, 3 strikes against Autism;(14:39) Subject Switching and Criteria B conflict(17:14) If you have met one child with Autism, you have met one child with Autism(17:49) Elementary School, 2 reasons why Reading is HARD, Social dynamic experience;(23:07) 4th Grade personal experience- easy task from the outside, tremendous difficulty for Autistics;(27:00) Art was fine, other subjects were not fine; Details to General versus General to Details;(27:58) High School personal experiences; Pathway to Success > General Education;(29:52) Did I graduate, or Not?(31:56) SAT(32:43) Assessment Superpowers and Superdeficits- Very Superior to Severe/Impaired; Schools simply cannot accommodate to all- within group (Autistic to Autistic) or between group (Autistic to Masses)(36:34) Education Arrangement; Taking Notes is challenging(39:16) Wrap Up, Reviews, Ratings, Feedback, Contact Information

There is no question Mothers that have children with Autism are incredible. You are loved and appreciated.

Criteria B is Autism. Hans Aspergers called the children with the syndrome "little professors." This is Autism. Our routines and fixated interests. Autism gives us the ability to be comfortable within ourselves, and this accelerates our abilities, our Superpowers. How will society handle these so-called "differences" and the conflict within the so-called "normal" people?In this episode, we expand to real-life examples of Criteria B components and review some personal experiences.Dopamine Nation (Pleasure and Pain SeeSaw) https://www.annalembke.comhttps://www.templegrandin.com/templegrandinbooks.html(0:00) Intro; Autism is Criteria B, how will society handle "differences," those differences create conflict in others, stimulus-response, conflict, and comfort(4:44) Routines (B2) and Plans, Exact Planning, Plan versus Actual Time and Execution, Reality meets our Visualized Thinking; Pleasure and Pain SeeSaw; More Relationship Struggles Implicated by Criteria B,(9:01) Punctual- for others and ourselves; Bias yourself into Action; Understanding the need for Breaks; Others take the easy way out; get Sunlight for our Biology(12:34) Personal Experience and a Glimpse into an Autistic Thought; Traffic Spacing(16:33) Researching Items and Fixated Interests (B3); personal experience; Hans Aspergers and his Little Professors- This is Autism!(20:40) Other examples- Pant Sizes and Alpha instead of Numerical, Restaurant Rant, Never Underestimate a Human's Capacity to Think; Don't try to change Autism because it is offends you- offends your expectations and beliefs(23:12) Reviews and Ratings and Contact Information

Don't try to change an Autistic Person because they are "different" than you. In this episode, we explore more examples of Criteria A- Deficits in Social Communication and Interaction. Yay, more DSM-5-TR. Can you fit in, or not? Are you like the so-called "normal" people, or not? This episode is highlighted by personal experiences and examples. Plus, I have three jokes. The examples and episode is not exhaustive, however, I try to capture some of the conditions on the spectrum. There are lots of examples in our social world that just does not make sense, and we like to say, "that does not make sense."See Jack Kruse, Quantum Engineering 45(0:00) Introduction; Crude Symptoms intend to capture the Spectrum; Can you fit in, or not? Are you like the so-called normal people, or not?(2:08) Facts and Reality over Make-Believe; Methodical and Seeing Bottlenecks in Society- I hate "that's just the way it is"; Traffic; Names- Landon?, Associations; Repeating things- I hate, "like I said."(7:09) "This does not make Sense"; Romantic Interests and Joke 1; Verbal Responses; Task-Switching from Fixated Interests; Sound Blends(11:44) Social Media Use- Strange; Eye-Contact- Humans say we need to do it, and We are not Birds; Leaving Social Gatherings and Joke 2, the gathering will gather without me(15:32) High-Fives = Stereotypy?; I hate Favors- favors create conflict; Henry David Thoreau; Self-Checkout Lanes and Autism, Neuroplasticity and Preference; Emotional Empathy(20:04) Debriefing and Understanding; Supplementing Relationships and Visual Thinking; Joke 3 and Fixated Interests and Perfect Intensity- the DSM can have it's "abnormal" label; Echolalia; Fitting In and Modeling as a Blueprint(26:03) Wrap-Up; Don't try to change an Autistic Person because They are "different" than you; Contact Information

In Part 2 of the Excitation and Inhibition phenomena, we discuss Metabolic "bank" account and demands of navigating the social world. We discuss if we have enough resources or if we will run a metabolic deficits (think burnout and avoidance, and social isolation). We cover NMDA and AMPA and different Autistic Phenotypes. In addition, we review Neuromodulators, which are vast in our biology and determine how and where to direct our attention and energy. Lastly, we discuss the medial Prefrontal Cortex and how it integrates the "self" with the outside world.Don't try to change an Autistic person because they are different than you or different than others. Don't let that offend your beliefs and capacity to apply critical thinking in life.https://www.nature.com/articles/s41398-023-02317-5https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/https://www.nature.com/articles/s41398-018-0155-1https://www.nature.com/articles/nature10360https://onlinelibrary.wiley.com/doi/full/10.1034/j.1601-183X.2003.00037.x?sid=nlm%3Apubmedhttps://www.nature.com/articles/s41380-022-01506-w(0:00) Introduction; Know Autism and Make Informed Decisions; Biological Aspects influencing Excitation / Inhibition Phenomena(4:30) Metabolic "Bank" Account and Resources; E/I creates criteria A and B; NMDA and AMPA, and more on the Striatum(10:02) Neuromodulators- Serotonin, Dopamine, Epinephrine and Norepinephrine, Acetylcholine; Active versus Passive Coping; Activating Systems and Cells and influencing Learning and Memory (Neuroplasticity); Nicotinic Receptors and Rapid-Excitation(15:20) medial Prefrontal Cortex (mPFC)- Metabolic demands and planning while considering Feelings, Integrating the Self and the Outside World; How E/I interacts; a brief explanation on Default Mode Network; Quieting the Body, or not; Information-Processing; Thalamocortical(20:19) Pursuits and Preference- Wanting and Having and being Autistic is fine, and others need to accept our phenotypes; sensory-input causes Faster Firing Rates in normal E/I- Image an imbalanced E/I(22:25) Wrap-up and understanding Autism, and Contact Info

In this episode, we discuss the Excitation and Inhibition Phenomena in Autism. There are many biological aspects implicating the E/I balance, and the Nervous System needs a healthy balance. This episode extends slightly downstream of the Genetic and Protein implications previously discussed. We discuss cortical and subcortical areas, sensations, introduce Glutamate and GABA, and discuss the critical period. The critical period is, pardon the pun, a critical period for Autism. In addition, we discuss BDNF and introduce neuroplasticity. Finally, we discuss Melanin and Melanopsin and sunlight and modern light, and the vast implications from our new environment. To end, we connect many modern diseases to these biological factors.See Dr. Jack Kruse Quantum Engineering 45Email: [email protected]

In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary. Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdfPTEN and mTOR https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01435-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014358%3Fshowall%3Dtrue16p11.2, Serotonin, and Possible Social Deficit Rescueshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/https://www.nature.com/articles/s41586-018-0416-4https://www.nature.com/articles/s41386-021-01091-6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/https://www.sciencedirect.com/science/article/pii/S0092867414006734(0:00) Introduction; Excitation and Inhibition; (3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should? (10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help;(13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch;(19:24) Back to 16p11.2 and Cortical Development;(22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability;(24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination;(25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC(29:25) Wrap Up and Contact Informationemail: [email protected]

In today's episode, we discuss Criteria A in the DSM-5-TR, which involves social communication and interaction. We discuss various aspects of the social world including unpredictableness, sensory processing being overwhelmed from the rapid firehose of information, being a student in a classroom, empathy, and are Autistic's being changed instead of cultivated into their own unique gifts (or Superpowers).Autism and Empathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484273/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804307/More from CNTNAP-2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/https://www.cell.com/fulltext/S0092-8674(11)01010-5Sir Simon Baron-Cohen https://www.psychol.cam.ac.uk/people/simon-baron-cohenTemple Grandin https://www.templegrandin.comDeisseroth on Socialness https://www.youtube.com/watch?v=gOWnf1BpkGsDSM (don't get hitched on this book) https://www.psychiatry.org/psychiatrists/practice/dsm(0:00) Introduction;(2:12) A1; don't change others just because; joining conversation; unpredictableness, protection, sensory processing and sounds blending; firehose of information;(15:11) A2; don't change others just because pt. 2 and ABA therapy; interests are easier for all; challenges in the classroom and mental effort;(21:09) A3; challenges with play as a child; strict rule adherence; imaginative play, even when good, is bad; fits and tantrums; speech and peers; empathy- emotional versus cognitive- ASD is better at emotional empathy; supplementing relationships later in life with small talk; relationships are hard!(31:32) Leo Kanner correction- Nervous Child, not Pathology- Pathology section in Nervous Child;(31:54) Final Thoughts; contact information and reaching out to meEmail- [email protected]

In this episode, we discuss criteria B from the DSM-5-TR. Criteria B are known as Restricted and Repetitive Behaviors. In addition, we discuss how criteria B implicates criteria A, or the social communication and interaction aspects of Autism. Projections https://www.amazon.com/Projections-Story-Human-Emotions/dp/B08LDWC2L6/ref=sr_1_4?crid=1GPPI5ZOFM2OS&dib=eyJ2IjoiMSJ9.nkY0ZQ0_m001QwcD7GiPwEwRdZitzaWU2NDjvRw_-xiCyiXLlyVfEZSzmonDa2coKQXiPSas9JLw1NeXBBjVh-I5pYHXvMVnLvB9vFwniO7QRoSLMGL3Idst8j8oqskuyPjy1UlNxZR23U_Ch22UJLU033T0wsMJNyZE6FcDepX8XAZAlXqeWXAHRXYD6jhVQLF771sNzRg3o_tKPJBoDr7GF0TWaaX5Nl7Mynmvvc4.Yfa8m249WY_xvl2E3TGObX7BoDhrJ_nU9R8d0ezWL34&dib_tag=se&keywords=projections&qid=1711134807&sprefix=projections%2Caps%2C100&sr=8-4Peter Attia and Karl Deisseroth https://youtu.be/4oiKOX2lCmE?si=Ru7W7cPpDDxtE8QrFuture Treatment possibilities https://youtu.be/eeySrgKev2g?si=IbX5h6qG5ddBPeO5Leo Kanner https://psycnet.apa.org/record/1943-03624-001Meet My Autistic Brain Episode https://podcasts.apple.com/us/podcast/meet-my-autistic-brain/id1548001224?i=1000629007371APA's DSM-5-TR https://www.psychiatry.org/psychiatrists/practice/dsm(But don't get hitch on this book)Time ScalesIntroduction (0:00)A Brief History (1:29)Similar Disorders (or Phenomena) (2:25)Levels of Autism; Criteria A and B; Superpowers and Superdeficits (5:16)Criteria B; B1 Stereotyped or Repetitive Motor Movements, Use of Objects, or Speech; Stimming; Echolalia Example (9:40)B2 Insistence on Sameness, Inflexible Adherence to Routines, or Ritualized Patterns of Verbal or Non-Verbal Behavior; Rigid Thinking Patterns and Gray Areas cause Problems; BEE MOVIE example (16:24)B3 Highly Restricted, Fixated Interests that are "Abnormal" in Intensity or Focus; Find your Interests and Superpowers and Do That; Vietnam War; Memorization, Accelerated Learning and Personal Example (22:37)B4 Hyper or Hyperactivity to Sensory Input or Unusual Interests in Sensory Aspects of the Environment; Complications with Eye-Contact and Keeping Up; Sensory Processing Phenomena; Visualization and the Eyes (32:47)