Dr. Richard Frye, MD, PhD: All about Leucovorin & Benefits for the Autistic Phenotype
From the Spectrum: Finding Superpowers with Autism · Ryan Sumner
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Show Notes
For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.
Dr. Frye shares many figures during the conversation so the listener can follow along.
Dr. Richard Frye https://drfryemdphd.com
Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter
Neurological Health Foundation https://neurologicalhealth.org
Healthy Child Guide https://neurologicalhealth.org/the-guide-5/
Daylight Computer Company https://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3w
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0:00 Dr. Richard Frye
0:58 Daylight Computer Company
5:17 Chroma Light Devices
8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa)
10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid)
14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase)
17:34 Cerebral Folate deficiency; BH4, Placenta & Womb
23:35 Folate deficiency & Autism
26:21 Clinical Studies & Data
29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!)
34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors
40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration
42:53 Folate Autoantibodies & Maternal Health & Markers
45:30 Studies & Behavioral outcomes; inflammation & thyroid findings
46:58 Neural development; Language connections, white matter tracts & distal connections
48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida
51:08 Preparing for pregnancy
53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness
59:32 Guidance & Support
Hopp: https://www.hopp.bio/fromthespectrum
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