E477 | Jeremy Uzan, Singular: Chasing Pure Performance, Generalist VCs & Why Europe is Ready for Science-Driven Founders

In this episode,

is joined by

, co-founder and GP at

, for a look at how a “plain vanilla” approach to venture—driven by deep founder focus and relentless performance orientation — can be a powerful advantage. Together, they unpack the mechanics behind Singular’s model, how the team stays agile without a rigid thesis, and what it means to create an empowering internal culture. Singular is an early-stage venture capital firm born in Europe, committed to empowering European founders with global ambitions across all sectors, from Seed to Series B, with a strong focus on Series A companies.Jeremy also shares his evolving views on European talent, the rise of Paris as a startup epicenter, and why he believes we’re only just beginning to unlock the entrepreneurial potential of Europe’s scientific minds.

Here’s what’s covered:

• 02:00 – Should Generalist VCs Still Exist in Europe
• 07:10 – Fundraising Like a Founder: How LPs Backed Fund I and II

• 14:00 – Why Generalist Isn’t a Weakness—It’s Strategic
• 16:25 – Diversification vs. Focus: Squaring LP Needs with Performance
• 21:15 – Temporary Specialists: Sprinting Deep Into Sectors
• 24:20 – From Zero to One on Markets: Learning via Founders
• 27:15 – European Talent Post-COVID: What’s Changed
• 30:00 – Paris Joins the Core of the European Ecosystem
• 35:15 – The Rise of Science Entrepreneurs in Europe
• 39:00 – Why Bio is the Next Big Tech Frontier