Cardiology Today

Welcome to Cardiology Today – Recorded October 05, 2025. This episode summarizes 1 key cardiology studies on topics like mechanical circulatory support and heart transplant. Key takeaway: Heart Transplant Bridge: Best Strategy for Outcomes. Article Links: Article 1: Post-Transplant Outcomes by Bridging Strategy: A Nationwide Multicenter Study of Heart Transplant Recipients in Korea. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/heart-transplant-bridge-best-strategy-for-outcomes-10-05-25/ Featured Articles Article 1: Post-Transplant Outcomes by Bridging Strategy: A Nationwide Multicenter Study of Heart Transplant Recipients in Korea. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41046003 Summary: This nationwide multicenter retrospective study analyzed 1,021 adult heart transplant recipients in Korea from 2014 to 2023, comparing post-transplant outcomes based on their pre-transplant bridging strategy: Extracorporeal Membrane Oxygenation, Left Ventricular Assist Device, or no mechanical circulatory support. The study determined crucial differences in post-transplant outcomes, including survival and complication rates, demonstrating the differential impact of each bridging strategy. These findings provide vital evidence for refining heart transplant allocation protocols and optimizing the selection of mechanical circulatory support to improve long-term patient survival and mitigate post-transplant complications, particularly in systems prioritizing E.C.M.O. as a bridge to transplant. Transcript Today’s date is October 05, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Post-Transplant Outcomes by Bridging Strategy: A Nationwide Multicenter Study of Heart Transplant Recipients in Korea. This nationwide multicenter retrospective study analyzed 1,021 adult heart transplant recipients in Korea from 2014 to 2023, comparing post-transplant outcomes based on their pre-transplant bridging strategy: Extracorporeal Membrane Oxygenation, Left Ventricular Assist Device, or no mechanical circulatory support. The study determined crucial differences in post-transplant outcomes, including survival and complication rates, demonstrating the differential impact of each bridging strategy. These findings provide vital evidence for refining heart transplant allocation protocols and optimizing the selection of mechanical circulatory support to improve long-term patient survival and mitigate post-transplant complications, particularly in systems prioritizing E.C.M.O. as a bridge to transplant. Thank you for listening. Don’t forget to subscribe. Keywords mechanical circulatory support, heart transplant, post-transplant outcomes, extracorporeal membrane oxygenation, left ventricular assist device. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Heart Transplant Bridge: Best Strategy for Outcomes 10/05/25 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded October 04, 2025. This episode summarizes 5 key cardiology studies on topics like L.R.P.5. and W.N.T. signaling. Key takeaway: Radiation Safe for Leadless Pacemakers. Article Links: Article 1: LRP5, a WNT signalling pathway receptor, and platelet activation. (European heart journal) Article 2: Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction. (European heart journal) Article 3: Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided PCI. (Heart (British Cardiac Society)) Article 4: Ventricular Repolarisation is Improved by His Resynchronisation Therapy but not Biventricular Pacing. (Heart rhythm) Article 5: Leadless Pacemakers Are Unaffected by External Beam Radiation in a Phantom Model. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/radiation-safe-for-leadless-pacemakers-10-04-25/ Featured Articles Article 1: LRP5, a WNT signalling pathway receptor, and platelet activation. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41042971 Summary: This study rigorously examined the role of L.R.P.5., a W.N.T. signaling pathway receptor, in regulating platelet function and hemostasis. Researchers utilized human platelets and L.R.P.5.-deficient murine platelets, challenging them with various agonists and inhibitors. The investigation revealed specific mechanisms by which L.R.P.5. influences platelet aggregation and activation pathways. These findings delineate L.R.P.5.’s critical involvement in thrombogenesis, suggesting it as a potential novel target for antiplatelet therapies. Article 2: Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41042950 Summary: This study investigated the heterogeneity of endothelial dysfunction in non-hypertensive obese individuals and sought to identify predictive and therapeutic serum metabolites. Utilizing wire myography, researchers confirmed that taurochenodeoxycholic acid, a specific bile acid, effectively alleviates obesity-induced endothelial dysfunction. This breakthrough suggests taurochenodeoxycholic acid could serve as a novel therapeutic target for preventing or treating cardiovascular disease in obese patients. Article 3: Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided PCI. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043864 Summary: The P.R.O.M.I.S.E. P.C.I. randomized trial, involving 1706 high-risk patients, compared the clinical utility of routine surveillance stress testing versus a symptom-oriented strategy after imaging-guided or physiology-guided percutaneous coronary intervention. The study aimed to definitively establish whether routine stress testing provides additional clinical benefit in this population. While the abstract does not detail the specific outcomes, the comprehensive trial results defined the optimal follow-up approach for enhancing post-P.C.I. patient management. Article 4: Ventricular Repolarisation is Improved by His Resynchronisation Therapy but not Biventricular Pacing. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043630 Summary: This study directly compared His-bundle pacing cardiac resynchronization therapy with biventricular pacing cardiac resynchronization therapy for their effects on ventricular repolarization in patients with left bundle branch block. The pivotal finding was that His-bundle pacing cardiac resynchronization therapy significantly improved ventricular repolarization, while biventricular pacing did not confer this benefit. This suggests His-bundle pacing offers a superior physiological approach to cardiac resynchronization, potentially reducing ventricular arrhythmia risk. Article 5: Leadless Pacemakers Are Unaffected by External Beam Radiation in a Phantom Model. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043629 Summary: This phantom model study assessed the impact of external beam radiation on leadless pacemakers, specifically the Medtronic Micra V.R., using advanced Varian TrueBeam and Ethos systems across various dose rates and flattening filter-free radiation modes. The study conclusively demonstrated that leadless pacemakers remain unaffected by radiation exposure. This crucial finding provides reassuring evidence for managing cancer patients with leadless pacemakers requiring radiation therapy, potentially simplifying treatment protocols. Transcript Today’s date is October 04, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. LRP5, a WNT signalling pathway receptor, and platelet activation. This study rigorously examined the role of L.R.P.5., a W.N.T. signaling pathway receptor, in regulating platelet function and hemostasis. Researchers

Welcome to Cardiology Today – Recorded October 03, 2025. This episode summarizes 5 key cardiology studies on topics like gene-edited pigs and H.C.N.4. Key takeaway: Osimertinib Arrhythmia: K.C.N.N.1 Link Found. Article Links: Article 1: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System. (Circulation) Article 2: Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese HFpEF. (JACC. Heart failure) Article 3: Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia. (Heart rhythm) Article 4: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment. (Heart rhythm) Article 5: Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/osimertinib-arrhythmia-k-c-n-n-1-link-found-10-03-25/ Featured Articles Article 1: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41036838 Summary: Article number one. Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System. Article 2: Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese HFpEF. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41037837 Summary: Article number two. Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese Heart Failure with Preserved Ejection Fraction. Article 3: Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40653133 Summary: Article number three. Osimertinib induces prolongation of action potential duration via downregulation of K.C.N.N.1 expression: Exploring the potential mechanisms of arrhythmia. Article 4: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40645436 Summary: Article number four. microRNA-363-5p- and I.L.-34-mediated modulation of pacemaker channel, H.C.N.4, on induced pluripotent stem cell-derived cardiomyocytes: Translation into the human sinus node microenvironment. Article 5: Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40582687 Summary: Article number five. Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation. Transcript Today’s date is October 03, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System. Article number two. Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese Heart Failure with Preserved Ejection Fraction. Article number three. Osimertinib induces prolongation of action potential duration via downregulation of K.C.N.N.1 expression: Exploring the potential mechanisms of arrhythmia. Article number four. microRNA-363-5p- and I.L.-34-mediated modulation of pacemaker channel, H.C.N.4, on induced pluripotent stem cell-derived cardiomyocytes: Translation into the human sinus node microenvironment. Article number five. Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation. Thank you for listening. Don’t forget to subscribe. Keywords gene-edited pigs, H.C.N.4, epidermal growth factor receptor-tyrosine kinase inhibitor, induced pluripotent stem cell-derived cardiomyocytes, incidence, cardiotoxicity, congestion, heart rate modulation, Heart Failure with Preserved Ejection Fraction, echocardiographic imaging, pacing complications, cardiac tamponade, osimertinib, arrhythmia, sinus node, pig-to-human heart transplant, xenotransplantation, action potential duration, transvenous temporary pacing, multimodal phenotyping, xeno-immune response, obesity, cardiac perforation, low cardiac output, I.L.-34, K.C.N.N.1, microRNAs, hemodynamic phenotype, clinical outcomes. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Osimertinib Arrhythmia: K.C.N.N.1 Link Found 10/03/25 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded October 02, 2025. This episode summarizes 5 key cardiology studies on topics like Transcatheter aortic valve replacement and Calcium current. Key takeaway: L-Type Calcium Channels Rescues Dilated Cardiomyopathy. Article Links: Article 1: PVL in ACURATE neo2 self-expanding aortic valve prosthesis for transcatheter aortic valve replacement – A multicenter retrospective registry analysis. (International journal of cardiology) Article 2: Performance evaluation of four scoring systems for mortality prediction in a contemporary cardiac intensive care unit. (International journal of cardiology) Article 3: Validation of MitraScore in diverse mitral regurgitation subtypes: Insights from the OCEAN-mitral registry. (International journal of cardiology) Article 4: Evaluating cardiovascular risk factors in breast cancer survivors: The role of echocardiography and cardiopulmonary exercise testing in the Munich Cardio-Oncology-Exercise retrospective Registry. (International journal of cardiology) Article 5: RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/l-type-calcium-channels-rescues-dilated-cardiomyopathy-10-02-25/ Featured Articles Article 1: PVL in ACURATE neo2 self-expanding aortic valve prosthesis for transcatheter aortic valve replacement – A multicenter retrospective registry analysis. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40446851 Summary: in A.C.U.R.A.T.E. neo2 self-expanding aortic valve prosthesis for transcatheter aortic valve replacement – A multicenter retrospective registry analysis. This multicenter retrospective registry analyzed predictors of paravalvular leak (P.V.L.) following implantation of the A.C.U.R.A.T.E. neo2 self-expanding aortic valve prosthesis during transcatheter aortic valve replacement (T.A.V.R.). The study evaluated if dedicated implantation techniques could further reduce P.V.L., a known complication the valve’s extended sealing skirt aims to mitigate. Such findings are critical for optimizing T.A.V.R. procedures and improving patient outcomes by minimizing post-procedural regurgitation. Article 2: Performance evaluation of four scoring systems for mortality prediction in a contemporary cardiac intensive care unit. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40446850 Summary: This prospective, single-center cohort study evaluated the performance of four established scoring systems for predicting 90-day mortality in patients admitted to a contemporary Cardiac Intensive Care Unit (C.I.C.U.). Researchers compared the Acute Physiology and Chronic Health Evaluation (A.P.A.C.H.E.), Sequential Organ Failure Assessment (S.O.F.A.), Mayo C.I.C.U. Admission Risk Score (M.C.A.R.S.), and Clinical Frailty Scale (C.F.S.) scores in an unselected C.I.C.U. population. The findings identified which scoring systems offer superior predictive accuracy, thereby providing critical guidance for risk stratification and clinical decision-making in this high-risk patient group. Article 3: Validation of MitraScore in diverse mitral regurgitation subtypes: Insights from the OCEAN-mitral registry. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40441608 Summary: This study conducted an external validation of MitraScore, a novel tool developed for predicting mortality risk in patients undergoing mitral transcatheter edge-to-edge repair (M-T.E.E.R.). Using data from the O.C.E.A.N.-Mitral registry, researchers assessed MitraScore’s performance across diverse mitral regurgitation (M.R.) subtypes, extending beyond its initial derivation in functional M.R. The validation confirmed the score’s accuracy in identifying patients at higher mortality risk, thereby enhancing patient stratification and selection for M-T.E.E.R. across a broader spectrum of M.R. etiologies. Article 4: Evaluating cardiovascular risk factors in breast cancer survivors: The role of echocardiography and cardiopulmonary exercise testing in the Munich Cardio-Oncology-Exercise retrospective Registry. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40425074 Summary: This retrospective, single-center study investigated cardiovascular disease risk factors (C.V.D.R.F.) in breast cancer survivors (B.C.S.) previously treated with either anthracycline/H.E.R.2-targeted therapy (A.C./H.) or endocrine therapy (E.T.). The research utilized echocardiography and cardiopulmonary exercise testing (C.P.E.T.) to assess cardiac function and fitness. The findings elucidated the differential impact of treatment regimens and the utility of these diagnostic tools in identifying B.C.S. at elevated C.V.D. risk, thereby informing tailored cardio-oncology surveillance strategies. A

Welcome to Cardiology Today – Recorded October 02, 2025. This episode summarizes 5 key cardiology studies on topics like preclinical diagnosis and psychosocial well-being. Key takeaway: A.I. Enables Preclinical ATTR-CM Diagnosis. Article Links: Article 1: Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis. (The New England journal of medicine) Article 2: Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy. (European heart journal) Article 3: Illicit stimulants and ventricular arrhythmias: a longitudinal cohort study. (European heart journal) Article 4: “Evolving Trends of Hypertension and Cerebral Infarction-Related Mortality in the United States from 2000-2020”. (The American journal of cardiology) Article 5: Moving Beyond Survival in Heart Transplantation. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/a-i-enables-preclinical-attr-cm-diagnosis-10-02-25/ Featured Articles Article 1: Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40513026 Summary: Article number one. Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis. Article 2: Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40679604 Summary: Article number two. Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy. Article 3: Illicit stimulants and ventricular arrhythmias: a longitudinal cohort study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40331280 Summary: Article number three. Illicit stimulants and ventricular arrhythmias: a longitudinal cohort study. Article 4: “Evolving Trends of Hypertension and Cerebral Infarction-Related Mortality in the United States from 2000-2020”. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41033593 Summary: Article number four. Evolving Trends of Hypertension and Cerebral Infarction-Related Mortality in the United States from 2000-2020. Article 5: Moving Beyond Survival in Heart Transplantation. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41033438 Summary: Article number five. Moving Beyond Survival in Heart Transplantation. Transcript Today’s date is October 02, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis. Article number two. Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy. Article number three. Illicit stimulants and ventricular arrhythmias: a longitudinal cohort study. Article number four. Evolving Trends of Hypertension and Cerebral Infarction-Related Mortality in the United States from 2000-2020. Article number five. Moving Beyond Survival in Heart Transplantation. Thank you for listening. Don’t forget to subscribe. Keywords preclinical diagnosis, psychosocial well-being, mortality trends, public health, pediatric care, illicit drug use, sudden cardiac death, intravenous rehydration, electrocardiography, stroke, fluid overload, transthoracic echocardiography, methamphetamine, cerebral infarction, Severe acute malnutrition, Heart transplantation, cocaine, immunosuppressive therapy, quality of life, Artificial intelligence, long-term outcomes, Hypertension, gastroenteritis, transthyretin amyloid cardiomyopathy, Ventricular arrhythmias. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post A.I. Enables Preclinical ATTR-CM Diagnosis 10/02/25 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded October 01, 2025. This episode summarizes 5 key cardiology studies on topics like diagnostic imaging and Cardiovascular health score. Key takeaway: Targeted Therapies Transform A.T.T.R.-C.M. Outcomes. Article Links: Article 1: Central Adiposity or Hypertension: Which Drives Heart Failure With a Preserved Ejection Fraction? (Journal of the American College of Cardiology) Article 2: Transthyretin amyloid cardiomyopathy: from cause to novel treatments. (European heart journal) Article 3: Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. (JAMA cardiology) Article 4: Cumulative Cardiovascular Health Score Through Young Adulthood and Cardiovascular and Kidney Outcomes in Midlife. (JAMA cardiology) Article 5: A Deep Learning Model to Identify Mitral Valve Prolapse From the Echocardiogram. (JACC. Cardiovascular imaging) Full episode page: https://podcast.explainheart.com/podcast/targeted-therapies-transform-a-t-t-r-c-m-outcomes-10-01-25/ Featured Articles Article 1: Central Adiposity or Hypertension: Which Drives Heart Failure With a Preserved Ejection Fraction? Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41031977 Summary: Article number one. Central Adiposity or Hypertension: Which Drives Heart Failure With a Preserved Ejection Fraction? Article 2: Transthyretin amyloid cardiomyopathy: from cause to novel treatments. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41030053 Summary: Article number two. Transthyretin amyloid cardiomyopathy: from cause to novel treatments. Article 3: Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41032333 Summary: Article number three. Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. Article 4: Cumulative Cardiovascular Health Score Through Young Adulthood and Cardiovascular and Kidney Outcomes in Midlife. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41032326 Summary: Article number four. Cumulative Cardiovascular Health Score Through Young Adulthood and Cardiovascular and Kidney Outcomes in Midlife. Article 5: A Deep Learning Model to Identify Mitral Valve Prolapse From the Echocardiogram. Journal: JACC. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41031982 Summary: Article number five. A Deep Learning Model to Identify Mitral Valve Prolapse From the Echocardiogram. Transcript Today’s date is October 01, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Central Adiposity or Hypertension: Which Drives Heart Failure With a Preserved Ejection Fraction? Article number two. Transthyretin amyloid cardiomyopathy: from cause to novel treatments. Article number three. Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. Article number four. Cumulative Cardiovascular Health Score Through Young Adulthood and Cardiovascular and Kidney Outcomes in Midlife. Article number five. A Deep Learning Model to Identify Mitral Valve Prolapse From the Echocardiogram. Thank you for listening. Don’t forget to subscribe. Keywords diagnostic imaging, Cardiovascular health score, artificial intelligence, Dilated Cardiomyopathy, hypertension, Heart Failure with Preserved Ejection Fraction, Mitral Valve Prolapse, echocardiography, polygenic score, amyloid reduction, A.T.T.R.-C.M., transthyretin stabilizers, waist-to-height ratio, prevention, kidney events, body mass index, tafamidis, peripartum cardiomyopathy, cancer therapy-related cardiomyopathy, midlife cardiovascular disease, young adulthood, central adiposity, Transthyretin amyloid cardiomyopathy, Deep learning, alcohol-induced cardiomyopathy. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Targeted Therapies Transform A.T.T.R.-C.M. Outcomes 10/01/25 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded October 01, 2025. This episode summarizes 5 key cardiology studies on topics like Percutaneous Coronary Intervention and ARCHBR criteria. Key takeaway: RV Myocardial Work Predicts CRT Success. Article Links: Article 1: Noninvasive Right Ventricular Myocardial Work by Pressure-Strain Loop: A New Perspective on Right Ventricular Function and Cardiac Resynchronization Therapy. (The American journal of cardiology) Article 2: Five Years After ARCHBR’s Global Introduction: A Prospective Validation Study in Egypt. (The American journal of cardiology) Article 3: The Impact of Comorbidity Patterns on Clinical Outcomes in Heart Failure: A Machine Learning-Based Cluster Analysis. (The American journal of cardiology) Article 4: Development and validation of an ECG algorithm based on lead V3 morphology to determine the origin of outflow tract ventricular arrhythmias. (International journal of cardiology) Article 5: Comparative analysis of machine learning models for coronary artery disease prediction with optimized feature selection. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/rv-myocardial-work-predicts-crt-success-10-01-25/ Featured Articles Article 1: Noninvasive Right Ventricular Myocardial Work by Pressure-Strain Loop: A New Perspective on Right Ventricular Function and Cardiac Resynchronization Therapy. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40414269 Summary: This study utilized noninvasive pressure-strain loop echocardiography to assess right ventricular myocardial work, finding that improvements in right ventricular myocardial work indices were associated with successful cardiac resynchronization therapy response. The research demonstrated that this novel tool provides a more precise estimation of right ventricular performance, highlighting its potential in predicting therapy success. Article 2: Five Years After ARCHBR’s Global Introduction: A Prospective Validation Study in Egypt. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40414268 Summary: This prospective validation study in an Egyptian percutaneous coronary intervention population assessed the ARCHBR criteria’s predictive utility for major bleeding after five years of global introduction. The study described contemporary bleeding patterns and established a regional benchmark for post-percutaneous coronary intervention major bleeding outcomes, indicating the continued relevance and applicability of the ARCHBR criteria. Article 3: The Impact of Comorbidity Patterns on Clinical Outcomes in Heart Failure: A Machine Learning-Based Cluster Analysis. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41027501 Summary: Utilizing machine learning on over one million heart failure patient records, this study identified five distinct comorbidity clusters and evaluated their association with short-term clinical outcomes. The findings highlight significant differences in clinical outcomes based on specific comorbidity patterns, underscoring the need for tailored management strategies for heart failure patients. Article 4: Development and validation of an ECG algorithm based on lead V3 morphology to determine the origin of outflow tract ventricular arrhythmias. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40460977 Summary: This study developed and validated an electrocardiogram algorithm using lead V3 morphology to accurately differentiate the origin of outflow tract ventricular arrhythmias, which is crucial for effective ablation planning. The algorithm demonstrated the potential to overcome the challenges of distinguishing these arrhythmias based on their electrocardiogram patterns, improving procedural guidance. Article 5: Comparative analysis of machine learning models for coronary artery disease prediction with optimized feature selection. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40456317 Summary: This study employed Bald Eagle Search Optimization for feature selection to enhance the performance of multiple machine learning models in predicting coronary artery disease. By optimizing feature selection, the research aimed to improve the accuracy and efficiency of non-invasive coronary artery disease prediction, offering a valuable alternative to traditional diagnostics. Transcript Today’s date is October 01, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Noninvasive Right Ventricular Myocardial Work by Pressure-Strain Loop: A New Perspective on Right Ventricular Function and Cardiac Resynchronization Therapy. This study utilized noninvasive pressure-strain loop echocardiography to assess right ventricular myocardial work, finding that improvements in right ventricular myocardial work

Welcome to Cardiology Today – Recorded October 01, 2025. This episode summarizes 5 key cardiology studies on topics like transcatheter aortic valve replacement and cardiac catheterization laboratory. Key takeaway: TAVR Outperforms Conservative Care in Low-Flow AS. Article Links: Article 1: Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis. (The New England journal of medicine) Article 2: Proton Pump Inhibitor Use, Gastrointestinal Bleeding Reduction, and Long-Term Prognosis After Percutaneous Coronary Intervention. (The American journal of cardiology) Article 3: Drug-Coated Balloon Versus Newer-Generation Drug-Eluting Stent Following Directional Coronary Atherectomy for Left Main Bifurcation Lesions. (The American journal of cardiology) Article 4: Association of Mechanical Circulatory Support and Cardiac Catheterization Laboratory Procedural Volumes With Outcomes of Cardiogenic Shock. (The American journal of cardiology) Article 5: Comparative Outcomes of Transcatheter Aortic Valve Replacement and Conservative Management in Patients with Low-Flow, Low-Gradient Aortic Stenosis. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/tavr-outperforms-conservative-care-in-low-flow-as-10-01-25/ Featured Articles Article 1: Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41025556 Summary: This phase 3 trial demonstrated that sotatercept, an activin-signaling inhibitor, significantly improved the 6-minute walk distance and reduced pulmonary vascular resistance in patients with pulmonary arterial hypertension diagnosed within the prior year. These findings suggest that early intervention with sotatercept offers substantial clinical benefit in this recently diagnosed patient population. Article 2: Proton Pump Inhibitor Use, Gastrointestinal Bleeding Reduction, and Long-Term Prognosis After Percutaneous Coronary Intervention. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40482871 Summary: This real-world study analyzed patients undergoing percutaneous coronary intervention and found that while proton pump inhibitors reduced gastrointestinal bleeding, there was no significant association with improved long-term prognosis, including major adverse cardiovascular events or mortality. The results suggest that the benefit of routine proton pump inhibitor use after percutaneous coronary intervention may be limited to gastrointestinal bleeding reduction alone. Article 3: Drug-Coated Balloon Versus Newer-Generation Drug-Eluting Stent Following Directional Coronary Atherectomy for Left Main Bifurcation Lesions. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40482870 Summary: This study compared drug-coated balloons to newer-generation drug-eluting stents after directional coronary atherectomy for left main bifurcation lesions, finding that both strategies had comparable rates of target lesion revascularization at one year. The results indicate that drug-coated balloons are a viable alternative to drug-eluting stents in this complex scenario, offering similar efficacy. Article 4: Association of Mechanical Circulatory Support and Cardiac Catheterization Laboratory Procedural Volumes With Outcomes of Cardiogenic Shock. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40451445 Summary: This analysis of the Nationwide Readmissions Database revealed that higher procedural volumes for mechanical circulatory support and cardiac catheterization laboratory procedures in hospitals were associated with lower mortality among cardiogenic shock admissions not receiving these specific interventions. The findings suggest that hospital experience with complex interventions indirectly benefits all cardiogenic shock patients by fostering expertise and improved care pathways. Article 5: Comparative Outcomes of Transcatheter Aortic Valve Replacement and Conservative Management in Patients with Low-Flow, Low-Gradient Aortic Stenosis. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40441582 Summary: This U.S.-based retrospective study compared outcomes for transcatheter aortic valve replacement versus conservative management in patients with low-flow, low-gradient aortic stenosis, demonstrating a significant reduction in mortality with transcatheter aortic valve replacement. The results strongly support transcatheter aortic valve replacement as the preferred strategy for select patients with this challenging form of aortic stenosis. Transcript Today’s date is October 01, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis. This phase 3 trial demonstrate

Welcome to Cardiology Today – Recorded September 30, 2025. This episode summarizes 5 key cardiology studies on topics like alternative splicing and dialysis. Key takeaway: Subclinical Aldosteronism Fuels MACE. Article Links: Article 1: Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study. (Circulation) Article 2: Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure. (Circulation) Article 3: Application of the J-CTO Score to Recanalization for In-Stent Chronic Total Occlusions. (The American journal of cardiology) Article 4: Predictors of permanent pacemaker implantation in patients with raphe-type bicuspid aortic valve stenosis undergoing TAVR. (The American journal of cardiology) Article 5: Comparative Effectiveness of Prasugrel versus Ticagrelor in Dialysis-Dependent end stage renal disease Patients Undergoing Percutaneous Coronary Intervention. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/subclinical-aldosteronism-fuels-mace-09-30-25/ Featured Articles Article 1: Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40631720 Summary: This longitudinal population-based study found that individuals with subclinical primary aldosteronism, a milder form of excessive aldosterone production, had a significantly increased risk of major adverse cardiovascular events. The findings suggest that subclinical primary aldosteronism is an underrecognized contributor to cardiovascular morbidity, emphasizing the need for its detection and management. Article 2: Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41017471 Summary: Leveraging long-read single-nucleus RNA sequencing, this study generated a detailed atlas of splicing isoform heterogeneity across adult human heart cell types and conditions. It identified significant shifts in isoform usage in heart failure, providing a foundational resource for understanding how alternative splicing contributes to cardiac disease at a molecular level. Article 3: Application of the J-CTO Score to Recanalization for In-Stent Chronic Total Occlusions. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41022251 Summary: This study evaluated the utility of the J-CTO score in guiding recanalization procedures for in-stent chronic total occlusions, comparing it to de novo chronic total occlusions. The results indicate that while the J-CTO score is a valuable tool for assessing procedural feasibility and predicting guidewire crossing time, its application and predictive accuracy may differ between in-stent and de novo chronic total occlusions. Article 4: Predictors of permanent pacemaker implantation in patients with raphe-type bicuspid aortic valve stenosis undergoing TAVR. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41022250 Summary: This registry-based study investigated the incidence, predictors, and clinical impact of permanent pacemaker implantation in patients with raphe-type bicuspid aortic valve stenosis undergoing transcatheter aortic valve replacement. The findings highlight specific patient and procedural characteristics associated with a higher likelihood of permanent pacemaker implantation, informing clinical decision-making. Article 5: Comparative Effectiveness of Prasugrel versus Ticagrelor in Dialysis-Dependent end stage renal disease Patients Undergoing Percutaneous Coronary Intervention. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41022249 Summary: This real-world cohort study compared the effectiveness and safety of prasugrel versus ticagrelor in end-stage renal disease patients on dialysis undergoing percutaneous coronary intervention. The study aimed to define optimal P2Y₁₂ inhibition in this high-risk, understudied population. Transcript Today’s date is September 30, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study. This longitudinal population-based study found that individuals with subclinical primary aldosteronism, a milder form of excessive aldosterone production, had a significantly increased risk of major adverse cardiovascular events. The findings suggest that subclinical primary aldosteronism is an underrecognized contributor to cardiovascular morbidity, emphasizing the need for its detection and management. Article number two. Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure. Leveraging long-read single-nucleus RNA sequencing, this study generated a detailed atlas of

Welcome to Cardiology Today – Recorded September 30, 2025. This episode summarizes 5 key cardiology studies on topics like pulmonary exacerbations and myocarditis. Key takeaway: Inflammation Predicts CV Events, Statin Benefit. Article Links: Article 1: Hypertonic Saline or Carbocisteine in Bronchiectasis. (The New England journal of medicine) Article 2: Artificial Intelligence Automation of Echocardiographic Measurements. (Journal of the American College of Cardiology) Article 3: Pop-Up Cardiovascular Screening Within Community Pharmacies and an International Sporting Event. (Journal of the American College of Cardiology) Article 4: Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology. (Journal of the American College of Cardiology) Article 5: An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/inflammation-predicts-cv-events-statin-benefit-09-30-25/ Featured Articles Article 1: Hypertonic Saline or Carbocisteine in Bronchiectasis. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41020514 Summary: This two-by-two factorial trial evaluated hypertonic saline versus carbocisteine for bronchiectasis exacerbations, enrolling participants with frequent exacerbations and daily sputum. The study aimed to assess the safety and effectiveness of these mucoactive agents in a large cohort, addressing inconsistencies in current guidelines. Article 2: Artificial Intelligence Automation of Echocardiographic Measurements. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40914895 Summary: This study developed and validated open-sourced deep learning semantic segmentation models to automate comprehensive echocardiographic measurements, aiming to reduce the time and imprecision associated with manual assessment. The goal is to leverage artificial intelligence to decrease clinician burden and improve diagnostic accuracy and longitudinal tracking of cardiovascular disease. Article 3: Pop-Up Cardiovascular Screening Within Community Pharmacies and an International Sporting Event. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40815240 Summary: This prospective observational study investigated an opportunistic pop-up screening approach for atherosclerotic cardiovascular disease risk within community pharmacies and at a sporting event over seven weeks. It aimed to identify differences in the captured populations based on screening location, day, and time to improve population-level screening uptake and compliance. Article 4: Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41020749 Summary: This scientific statement highlights the critical role of inflammation, particularly residual inflammation measured by high-sensitivity C-reactive protein, in the pathogenesis and outcomes of cardiovascular disease. It emphasizes that elevated high-sensitivity C-reactive protein predicts recurrent cardiovascular events even in statin-treated patients and identifies higher-risk individuals in whom statin therapy significantly reduces the risk of first major cardiovascular events. Article 5: An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40820798 Summary: This research explored the potential role of endogenous retrovirus resurgence in heart failure by establishing a total RNA sequencing pipeline to assess their occurrence in human and murine heart failure models. The study generated myocardium-specific mouse lines to investigate how this aberrant retroviral activity might induce myocarditis and contribute to the development of heart failure. Transcript Today’s date is September 30, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Hypertonic Saline or Carbocisteine in Bronchiectasis. This two-by-two factorial trial evaluated hypertonic saline versus carbocisteine for bronchiectasis exacerbations, enrolling participants with frequent exacerbations and daily sputum. The study aimed to assess the safety and effectiveness of these mucoactive agents in a large cohort, addressing inconsistencies in current guidelines. Article number two. Artificial Intelligence Automation of Echocardiographic Measurements. This study developed and validated open-sourced deep learning semantic segmentation models to automate comprehensive echocardiographic measurements, aiming to reduce the time and imprecision associated with manual assessment. The goal is to leverage artificial intelligence to decrease clinician burden and improve

Welcome to Cardiology Today – Recorded September 29, 2025. This episode summarizes 5 key cardiology studies on topics like Western diet and diastole. Key takeaway: Smoking Ignites Atrial Fibrillation Via Inflammasome. Article Links: Article 1: Hemodynamic Monitoring and Management of the Hypotensive Out-of-Hospital Cardiac Arrest Patient in the Adult Intensive Care Unit. (European heart journal. Acute cardiovascular care) Article 2: On the Measurement of the Vortex Formation Time in the Left Ventricle. (American journal of physiology. Heart and circulatory physiology) Article 3: Cigarette Smoking Induces NLRP3 Inflammasome Activation in Atrial Fibrillation Patients. (American journal of physiology. Heart and circulatory physiology) Article 4: Objective assessment of cardiac function using patient-specific biophysical modeling based on cardiovascular MRI combined with catheterization. (American journal of physiology. Heart and circulatory physiology) Article 5: Conventional Tobacco and Electronic Cigarettes Differentially Affect Cardiovascular Health in Male and Female Mice. (American journal of physiology. Heart and circulatory physiology) Full episode page: https://podcast.explainheart.com/podcast/smoking-ignites-atrial-fibrillation-via-inflammasome-09-29-25/ Featured Articles Article 1: Hemodynamic Monitoring and Management of the Hypotensive Out-of-Hospital Cardiac Arrest Patient in the Adult Intensive Care Unit. Journal: European heart journal. Acute cardiovascular care PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41014602 Summary: This review focuses on the critical management of hypotension defined as mean arterial blood pressure less than sixty-five millimeters of mercury in adult intensive care unit patients after out-of-hospital cardiac arrest. It highlights that post-resuscitation hypotension, potentially caused by arrhythmias or mechanical complications, significantly contributes to morbidity and mortality, necessitating precise hemodynamic monitoring and interventions. Article 2: On the Measurement of the Vortex Formation Time in the Left Ventricle. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015431 Summary: This study addresses inconsistencies in measuring vortex formation time, a potential metric for left ventricular performance during diastole, by proposing a new formulation grounded in fluid dynamics. It aims to clarify the measurement challenges and enhance the clinical utility of vortex formation time as an indicator of cardiac filling efficiency. Article 3: Cigarette Smoking Induces NLRP3 Inflammasome Activation in Atrial Fibrillation Patients. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015415 Summary: This research demonstrates that cigarette smoking directly activates the NLRP3 inflammasome, a key inflammatory pathway, in patients with atrial fibrillation. These findings establish a direct molecular link between smoking and the inflammation implicated in the initiation and persistence of atrial fibrillation. Article 4: Objective assessment of cardiac function using patient-specific biophysical modeling based on cardiovascular MRI combined with catheterization. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015406 Summary: This study presents a framework for synthesizing multi-modality data, specifically cardiovascular magnetic resonance imaging and catheterization, into patient-specific biophysical models. This approach facilitates noise filtering and quantifies myocardial contractility, offering objective assessments of cardiac function beyond readily available data metrics. Article 5: Conventional Tobacco and Electronic Cigarettes Differentially Affect Cardiovascular Health in Male and Female Mice. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015405 Summary: This research investigates the differential cardiovascular effects of conventional and electronic cigarettes in male and female mice, particularly when combined with a Western diet. The study evaluates aerosol exposures and their impact on cardiovascular health, comparing the risks of electronic cigarettes to traditional tobacco cigarettes. Transcript Today’s date is September 29, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Hemodynamic Monitoring and Management of the Hypotensive Out-of-Hospital Cardiac Arrest Patient in the Adult Intensive Care Unit. This review focuses on the critical management of hypotension defined as mean arterial blood pressure less than sixty-five millimeters of mercury in adult intensive care unit patients after out-of-hospital cardiac arrest. It highlights that post-resuscitation hypotension, potentially caused by arrhythmias or mechanical complicati

Welcome to Cardiology Today – Recorded September 29, 2025. This episode summarizes 5 key cardiology studies on topics like angiotensin two and fibroblast activation. Key takeaway: Septin4 Inhibition Reverses Cardiac Fibrosis. Article Links: Article 1: Septin4 Regulates Cardiac Fibrosis After Pressure Overload. (Circulation research) Article 2: DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function. (Circulation research) Article 3: Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice. (Circulation research) Article 4: Calcium Oscillations Within Juxtaglomerular Cell Clusters Control Renin Release. (Circulation research) Article 5: Incidence of major cardiovascular events in patients with metabolic dysfunction-associated steatotic liver disease in the general population. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/septin4-inhibition-reverses-cardiac-fibrosis-09-29-25/ Featured Articles Article 1: Septin4 Regulates Cardiac Fibrosis After Pressure Overload. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40960950 Summary: This study found that Septin4, a small G.T.P.ase, plays a crucial role in regulating cardiac fibrosis following pressure overload in the heart. Specifically, Septin4 deficiency reduced cardiac fibroblast activation and collagen deposition, leading to improved cardiac function and reduced heart failure progression in mice subjected to transverse aortic constriction. These findings suggest that targeting Septin4 could be a potential therapeutic strategy for mitigating cardiac fibrosis and heart failure. Article 2: DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40910184 Summary: Researchers demonstrated that DWORF, a cardiac microprotein, enhances sarco/endoplasmic reticulum calcium ATPase isoform 2a activity, improving calcium reuptake in cardiomyocytes. Gene therapy delivery of DWORF in a heart failure model improved cardiac calcium handling, mitochondrial function, and overall cardiac performance. This indicates that DWORF gene therapy represents a promising approach for treating heart failure by restoring calcium homeostasis. Article 3: Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40899274 Summary: in Hypertensive Mice. This research showed that partial reprogramming of endothelial cells can attenuate endothelial-to-mesenchymal transition in hypertensive mice. A single short pulse of reprogramming factors led to decreased blood pressure, improved endothelial function, and reduced small artery remodeling. This suggests that endothelial cell reprogramming could be a therapeutic strategy for hypertension by targeting endothelial dysfunction. Article 4: Calcium Oscillations Within Juxtaglomerular Cell Clusters Control Renin Release. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40899273 Summary: The study revealed that calcium oscillations within juxtaglomerular cell clusters are essential for controlling renin release, which regulates blood pressure and fluid-electrolyte balance. Juxtaglomerular cells respond to changes in blood pressure by modulating these calcium oscillations, thereby influencing renin secretion and subsequent angiotensin two production. Understanding these calcium signaling mechanisms could provide new targets for managing hypertension and related disorders. Article 5: Incidence of major cardiovascular events in patients with metabolic dysfunction-associated steatotic liver disease in the general population. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40999971 Summary: Analysis of a large population in Germany found that metabolic dysfunction-associated steatotic liver disease is significantly associated with an increased risk of major adverse cardiovascular events and overall mortality. Patients with metabolic dysfunction-associated steatotic liver disease had a higher incidence of cardiovascular events, highlighting the importance of cardiovascular risk management in this population. These findings underscore the need for integrated approaches addressing both liver and cardiovascular health in individuals with metabolic dysfunction-associated steatotic liver disease. Transcript Today’s date is September 29, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Septin4 Regulates Cardiac Fibrosis After Pressure Overload. This study found that Septin4, a small G.T.P.ase, plays a crucial role in regulating cardiac fibrosis following pressure overload in the heart. Specifically, Septin4 deficiency reduced cardiac fib

Welcome to Cardiology Today – Recorded September 29, 2025. This episode summarizes 5 key cardiology studies on topics like ablation depth and dilated cardiomyopathy. Key takeaway: L.V.A. Ablation Works Best in Enlarged Atria. Article Links: Article 1: Premature Ventricular Contractions on Healthy and Diseased Hearts: Differential Acute Effect of Coupling Interval and Location. (Heart rhythm) Article 2: Electrical Impedance Spectroscopy Facilitates Quantitative Depth Monitoring of Pulsed Field Ablation: An Impedimetric Approach with Preclinical Validation. (Heart rhythm) Article 3: What is the Diagnostic Utility of Cardiac Magnetic Resonance Imaging in Unselected Patients with Premature Ventricular Contractions and Non-Sustained Ventricular Tachycardia? (The American journal of cardiology) Article 4: Intellectual and Neurodevelopmental Delays in Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: Distinct Characteristics and a More Malignant Neurocardiac Phenotype. (Circulation. Arrhythmia and electrophysiology) Article 5: Efficacy of Low-Voltage-Area Ablation Is Enhanced in Patients With Advanced Left Atrial Enlargement: A Subanalysis of the SUPPRESS-AF Trial. (Circulation. Arrhythmia and electrophysiology) Full episode page: https://podcast.explainheart.com/podcast/l-v-a-ablation-works-best-in-enlarged-atria-09-29-25/ Featured Articles Article 1: Premature Ventricular Contractions on Healthy and Diseased Hearts: Differential Acute Effect of Coupling Interval and Location. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41016420 Summary: This swine study compared premature ventricular contraction induced changes in left ventricular pressure in healthy hearts versus hearts with dilated cardiomyopathy. Premature ventricular contractions delivered at shorter coupling intervals resulted in greater acute hemodynamic dysfunction, with this effect being more pronounced in diseased hearts. The findings suggest that premature ventricular contraction induced cardiomyopathy is likely related to the timing of the contraction and is exacerbated by pre-existing heart disease. Article 2: Electrical Impedance Spectroscopy Facilitates Quantitative Depth Monitoring of Pulsed Field Ablation: An Impedimetric Approach with Preclinical Validation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41016419 Summary: This preclinical study demonstrates that electrical impedance spectroscopy can accurately monitor ablation depth during pulsed field ablation procedures. The change rate of low-frequency impedance correlated with lesion depth in both monopolar and bipolar pulsed field ablation settings. This technology holds promise for real-time, quantitative assessment of ablation depth, potentially improving the safety and efficacy of pulsed field ablation for cardiac arrhythmias. Article 3: What is the Diagnostic Utility of Cardiac Magnetic Resonance Imaging in Unselected Patients with Premature Ventricular Contractions and Non-Sustained Ventricular Tachycardia? Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41016532 Summary: Cardiac Magnetic Resonance Imaging identified structural heart disease in a significant proportion of patients, with late gadolinium enhancement being the most common finding. Cardiac Magnetic Resonance Imaging is valuable for risk stratifying patients with premature ventricular contractions and non-sustained ventricular tachycardia, especially when clinical suspicion for structural heart disease is present. Article 4: Intellectual and Neurodevelopmental Delays in Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: Distinct Characteristics and a More Malignant Neurocardiac Phenotype. Journal: Circulation. Arrhythmia and electrophysiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41000018 Summary: This study identifies a distinct neurocardiac phenotype of catecholaminergic polymorphic ventricular tachycardia in children characterized by intellectual and neurodevelopmental delays. Patients with this phenotype exhibited a higher burden of ventricular arrhythmias and sudden cardiac death compared to those without neurodevelopmental delays. The findings suggest a more malignant form of catecholaminergic polymorphic ventricular tachycardia with unique clinical features requiring heightened surveillance and management. Article 5: Efficacy of Low-Voltage-Area Ablation Is Enhanced in Patients With Advanced Left Atrial Enlargement: A Subanalysis of the SUPPRESS-AF Trial. Journal: Circulation. Arrhythmia and electrophysiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41000017 Summary: This subanalysis of the SUPPRESS-A.F. trial reveals that low-voltage-area ablation for persistent atrial fibrillation is more effective in patients with advanced left atrial enlargement. Patients with larger left atrial diameters experienced a greater benefit from low-voltage-area ablation compared to those with less atrial remodeli

Welcome to Cardiology Today – Recorded September 28, 2025. This episode summarizes 5 key cardiology studies on topics like longitudinal study and cardiac electrophysiology. Key takeaway: Methadone’s Pro-Arrhythmic Cardiac Risks Confirmed. Article Links: Article 1: Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling. (Journal of the American Heart Association) Article 2: Interventional Partial Cavopulmonary Connection: Initial Clinical Experience With Acute Procedural up to Midterm Results. (Journal of the American Heart Association) Article 3: Trends and Racial and Ethnic Disparities in Maternal Cardiovascular Health in California. (Journal of the American Heart Association) Article 4: Design of Black Impact: A Randomized Controlled Trial Evaluating the Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention. (Journal of the American Heart Association) Article 5: Static and Dynamic Effects of Stroke Onset on Depressive Symptoms in Middle-Aged and Older Adults: Evidence Across 21 Countries. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/methadones-pro-arrhythmic-cardiac-risks-confirmed-09-28-25/ Featured Articles Article 1: Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996098 Summary: This computational modeling study reveals that methadone’s blockade of the inward rectifier potassium current and other ion channels promotes both early and delayed repolarization arrhythmias. By simulating methadone’s effects on cardiac electrophysiology, the study highlights the complex proarrhythmic mechanisms associated with methadone use, offering insights into its potential cardiac risks. These findings suggest that methadone-induced arrhythmias are not solely due to delayed repolarization, warranting careful E.C.G. monitoring in vulnerable patients. Article 2: Interventional Partial Cavopulmonary Connection: Initial Clinical Experience With Acute Procedural up to Midterm Results. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996081 Summary: This study evaluates the initial clinical experience with interventional creation of a partial cavopulmonary connection in patients with isolated right-sided heart failure or cyanosis. The procedure was found to improve exercise capacity and facilitate activities of daily living in patients with deteriorated clinical condition. While surgical partial cavopulmonary connection creation may be a high-risk procedure in this patient group, the interventional approach offers a less invasive alternative. Article 3: Trends and Racial and Ethnic Disparities in Maternal Cardiovascular Health in California. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996078 Summary: This analysis of California birth records from 2007 to 2019 reveals significant racial and ethnic disparities in maternal cardiovascular health, specifically hypertensive disorders of pregnancy. The study found variations in the prevalence and trends of these disorders among different racial and ethnic groups. These findings highlight the need for targeted interventions to address these disparities and improve maternal cardiovascular outcomes. Article 4: Design of Black Impact: A Randomized Controlled Trial Evaluating the Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996070 Summary: This article describes the design of the Black Impact randomized controlled trial, a 24-week cardiovascular health intervention developed for Black men. The study aims to evaluate the mechanisms by which psychosocial stress reduction improves cardiovascular health outcomes in this population, as measured by the American Heart Association’s Life’s Essential 8 metrics. The trial is conducted through an academic-community-government-industry partnership. Article 5: Static and Dynamic Effects of Stroke Onset on Depressive Symptoms in Middle-Aged and Older Adults: Evidence Across 21 Countries. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996069 Summary: This pooled multicohort study across 21 countries examined the relationship between stroke and depressive symptoms in adults aged 50 years and older. The study found that stroke is associated with an increased risk of depressive symptoms, highlighting the need for integrated mental health care following stroke. Both the initial stroke event and subsequent changes ov

Welcome to Cardiology Today – Recorded September 28, 2025. This episode summarizes 5 key cardiology studies on topics like heart failure and waist circumference. Key takeaway: Obesity: New Heart Failure Risk Factor?. Article Links: Article 1: Underrepresented patient populations in cardiovascular device trials: A transatlantic expert narrative on sex, age, demographic groups, and geographical background. (International journal of cardiology) Article 2: Poor cardiovascular outcomes of underweight abdominal obesity in the entire population of newly diagnosed heart failure. (ESC heart failure) Article 3: Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis. (ESC heart failure) Article 4: Simultaneous vaccination against influenza and respiratory syncytial virus in high-risk heart failure patients. (ESC heart failure) Article 5: Bridging Hypertension Care Shortfalls Between Provider Capacity and Patient Needs: A Pooled Analysis of Data From 199 Countries and Territories. (Hypertension (Dallas, Tex. : 1979)) Full episode page: https://podcast.explainheart.com/podcast/obesity-new-heart-failure-risk-factor-09-28-25/ Featured Articles Article 1: Underrepresented patient populations in cardiovascular device trials: A transatlantic expert narrative on sex, age, demographic groups, and geographical background. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015124 Summary: This article highlights the critical need to improve the representation of historically underrepresented patient groups—specifically defined by sex, age, demographic, and geographic diversity—in cardiovascular device trials to ensure external validity of clinical research. Addressing disparities in enrollment is essential, especially in countries with pronounced inequities, to promote equitable access to and benefit from cardiovascular technologies. Raising awareness is paramount to closing the gaps in future trials. Article 2: Poor cardiovascular outcomes of underweight abdominal obesity in the entire population of newly diagnosed heart failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40999962 Summary: This extensive study of nearly one million newly diagnosed heart failure patients in Korea over a decade revealed that underweight individuals with abdominal obesity exhibit poor cardiovascular outcomes. Body Mass Index alone may not be sufficient to assess cardiovascular risk in heart failure patients, highlighting the importance of considering waist circumference alongside B.M.I. for a more comprehensive risk stratification. These findings suggest the need for tailored management strategies for heart failure patients with this specific phenotype. Article 3: Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40999636 Summary: This study investigates the impact of epicardial adipose tissue on myocardial remodeling and function in patients with severe aortic valve stenosis undergoing transcatheter aortic valve replacement. Elevated epicardial adipose tissue volume is associated with adverse myocardial remodeling and dysfunction, potentially influencing outcomes post-transcatheter aortic valve replacement. Understanding these pathophysiological mechanisms could lead to targeted therapies aimed at reducing epicardial adipose tissue and improving outcomes in these patients. Article 4: Simultaneous vaccination against influenza and respiratory syncytial virus in high-risk heart failure patients. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40998567 Summary: A prospective, randomized trial demonstrated that simultaneous vaccination against influenza and respiratory syncytial virus in high-risk heart failure patients improves outcomes during the subsequent infection season. This suggests a proactive approach to respiratory virus prevention through vaccination can significantly reduce morbidity in this vulnerable population. The findings support the implementation of combined vaccination strategies as a standard of care for high-risk heart failure patients. Article 5: Bridging Hypertension Care Shortfalls Between Provider Capacity and Patient Needs: A Pooled Analysis of Data From 199 Countries and Territories. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41000007 Summary: This analysis of hypertension management across 199 countries highlights significant gaps between healthcare system capacity, specifically physician and non-physician provider density, and patient needs. The study reveals substantial shortfalls in hypertension care delivery, emphasizing the need for strategies to optimize healthcare workforce distribution and task-sharing to improve hypertension control globally. Addressing these gaps is cruci

Welcome to Cardiology Today – Recorded September 28, 2025. This episode summarizes 5 key cardiology studies on topics like accelerometry and sudden cardiac death. Key takeaway: Polygenic Risk Drives A.fib More in Men. Article Links: Article 1: Trends in burden of atrial fibrillation over three decades: a population-based study. (Heart (British Cardiac Society)) Article 2: Accelerometry-defined physical activity and quality of life in hypertrophic cardiomyopathy. (Heart (British Cardiac Society)) Article 3: Sex Differences in the Association between Polygenic Risk Score and Atrial Fibrillation Incidence: A Prospective Cohort Study. (The Canadian journal of cardiology) Article 4: Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy with residual obstruction after Alcohol Septal Ablation. (The Canadian journal of cardiology) Article 5: Association Between Electrocardiographic Changes and Myocardial Injury or Death after Cardiac Surgery. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/polygenic-risk-drives-a-fib-more-in-men-09-28-25/ Featured Articles Article 1: Trends in burden of atrial fibrillation over three decades: a population-based study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015500 Summary: This population-based study across three decades demonstrated an increase in atrial fibrillation prevalence, particularly in men, with age, hypertension, and heart failure being key risk factors. The observed increase in atrial fibrillation incidence remained stable over time, highlighting the persistent need for effective prevention and management strategies. The findings suggest a growing burden of atrial fibrillation, necessitating continued attention to risk factor modification and targeted interventions. Article 2: Accelerometry-defined physical activity and quality of life in hypertrophic cardiomyopathy. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40887133 Summary: This study, using accelerometry in patients with hypertrophic cardiomyopathy, revealed that reduced physical activity levels correlate with poorer quality of life, independent of left ventricular outflow tract obstruction. Patients with hypertrophic cardiomyopathy demonstrated significantly lower daily step counts compared to genotype-positive, phenotype-negative individuals. These findings underscore the importance of encouraging and supporting increased physical activity in hypertrophic cardiomyopathy patients to improve their overall well-being. Article 3: Sex Differences in the Association between Polygenic Risk Score and Atrial Fibrillation Incidence: A Prospective Cohort Study. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015248 Summary: This prospective cohort study of over 444,000 participants found that a higher polygenic risk score for atrial fibrillation was associated with an increased risk of developing atrial fibrillation, with this association being more pronounced in men compared to women. The sex-specific effects of the polygenic risk score were consistent across different levels of clinical risk as defined by the CHARGE-A.F. score. These results suggest that genetic predisposition to atrial fibrillation may differ between sexes, which could inform personalized risk stratification and prevention strategies. Article 4: Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy with residual obstruction after Alcohol Septal Ablation. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015247 Summary: This study investigated percutaneous intramyocardial septal radiofrequency ablation as a treatment for obstructive hypertrophic cardiomyopathy patients with persistent left ventricular outflow tract obstruction following alcohol septal ablation. The findings suggest that percutaneous intramyocardial septal radiofrequency ablation is a feasible option in carefully selected patients, demonstrating both acute and short-term reductions in left ventricular outflow tract gradients and improved symptoms. Further research is needed to assess long-term outcomes and identify optimal patient selection criteria. Article 5: Association Between Electrocardiographic Changes and Myocardial Injury or Death after Cardiac Surgery. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41015246 Summary: This study of patients undergoing cardiac surgery found that new potential ischemic E.C.G. changes after surgery were significantly associated with a higher risk of 30-day mortality. Specifically, new Q waves, S.T. segment depression, or T wave inversion were all independent predictors of increased mortality. These findings highlight the importance of vigilant post-operative E.C.G. monitoring for early detection of myocardial ischemi

Welcome to Cardiology Today – Recorded September 27, 2025. This episode summarizes 5 key cardiology studies on topics like amiodarone and mortality. Key takeaway: Hypertension Kills Young Adults: A U.S. Crisis. Article Links: Article 1: Surgical Aortic Valve Replacement Following TAVR: Long-Term Comparative Outcomes Versus Non-SAVR Cardiac Surgery. (The American journal of cardiology) Article 2: Effect of Amiodarone after Catheter Ablation According to Left Atrial Structure and Function: The AMIO-CAT Trial. (The American journal of cardiology) Article 3: Rising Burden of Hypertensive Heart Disease Mortality Among Young Adults in the United States, 1999 to 2024. (The American journal of cardiology) Article 4: Iron regulatory proteins secure iron availability in skeletal muscle to preserve exercise tolerance in heart failure. (Cardiovascular research) Article 5: Oxidized LDL-induced FOXS1 mediates cholesterol transport dysfunction and inflammasome activation to drive aortic valve calcification. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/hypertension-kills-young-adults-a-u-s-crisis-09-27-25/ Featured Articles Article 1: Surgical Aortic Valve Replacement Following TAVR: Long-Term Comparative Outcomes Versus Non-SAVR Cardiac Surgery. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41005597 Summary: This study, using the TriNetX network, compared surgical aortic valve replacement after transcatheter aortic valve replacement with other open-heart surgeries. After propensity score matching, no significant differences in mortality were observed between the two groups at three and five years. This suggests that surgical aortic valve replacement following transcatheter aortic valve replacement does not pose a significantly higher long-term mortality risk compared to other cardiac surgeries. Article 2: Effect of Amiodarone after Catheter Ablation According to Left Atrial Structure and Function: The AMIO-CAT Trial. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41005596 Summary: This post-hoc analysis of the A.M.I.O.-C.A.T. trial investigated whether left atrial structure and function modify the effect of amiodarone in preventing atrial fibrillation recurrence after catheter ablation. The study found that short-term amiodarone after catheter ablation reduces atrial fibrillation recurrence, but this effect is not significantly modified by left atrial size or function. These results do not support tailoring amiodarone use post-ablation based on left atrial characteristics. Article 3: Rising Burden of Hypertensive Heart Disease Mortality Among Young Adults in the United States, 1999 to 2024. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41005594 Summary: Analysis of national mortality data from 1999 to 2024 reveals a concerning increase in hypertensive heart disease mortality among U.S. adults aged 15 to 44. This rise was observed across various demographic subgroups, highlighting the need for targeted prevention and treatment strategies for hypertension in younger populations to curb cardiovascular mortality. Further studies are needed to find the cause for the increase. Article 4: Iron regulatory proteins secure iron availability in skeletal muscle to preserve exercise tolerance in heart failure. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40994366 Summary: This study explored the role of iron regulatory proteins in skeletal muscle function and exercise capacity in heart failure. The researchers found that skeletal muscle iron deficiency is associated with inactivation of iron regulatory proteins one and two, which impacts exercise tolerance in heart failure. Maintaining iron availability in skeletal muscle via iron regulatory proteins may be a therapeutic target to improve exercise capacity in heart failure patients. Article 5: Oxidized LDL-induced FOXS1 mediates cholesterol transport dysfunction and inflammasome activation to drive aortic valve calcification. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40990096 Summary: This research identifies the transcription factor F.O.X.S.1 in human valvular interstitial cells as a crucial regulator in aortic valve calcification. The study found that oxidized low-density lipoprotein induces F.O.X.S.1, which mediates cholesterol transport dysfunction and inflammasome activation, promoting aortic valve calcification. Targeting F.O.X.S.1 could offer a potential therapeutic avenue for preventing or slowing the progression of calcific aortic valve disease. Transcript Today’s date is September 27, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Surgical Aortic Valve Replacement Following TAVR: Long-Term Comparative Outcomes Versus Non-SAVR Cardiac Surgery. This study, using the TriNetX network, compared

Welcome to Cardiology Today – Recorded September 27, 2025. This episode summarizes 5 key cardiology studies on topics like polyneuropathy and hereditary transthyretin amyloidosis. Key takeaway: Lp(a) Levels Key for Cardio Risk. Article Links: Article 1: Nexiguran Ziclumeran Gene Editing in Hereditary ATTR with Polyneuropathy. (The New England journal of medicine) Article 2: Diagnostic accuracy of late gadolinium enhancement cardiac MRI for coronary artery disease in patients with reduced left ventricular ejection fraction. (Heart (British Cardiac Society)) Article 3: Prognostic impact of neutrophil-to-lymphocyte ratio in patients with and without diabetes mellitus undergoing percutaneous coronary intervention. (Heart (British Cardiac Society)) Article 4: The Role of Lipoprotein(a) in Cardiovascular Risk Stratification: IntegratingLow-density Lipoprotein Cholesterol and Polygenic Risk Scores. (The American journal of cardiology) Article 5: Optimal Intravascular Ultrasound-Guided Percutaneous Coronary Intervention in Patients With Left Main Coronary Artery Disease: The OPTIVUS-Complex PCI Study LMCA Cohort. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/lpa-levels-key-for-cardio-risk-09-27-25/ Featured Articles Article 1: Nexiguran Ziclumeran Gene Editing in Hereditary ATTR with Polyneuropathy. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41002250 Summary: with Polyneuropathy. This study investigates nexiguran ziclumeran, a C.R.I.S.P.R.-Cas9-based therapy designed to reduce serum transthyretin levels by selectively inactivating the TTR gene in patients with hereditary transthyretin amyloidosis with polyneuropathy. The therapy aims to address the underlying cause of the disease by preventing the misfolding and deposition of transthyretin protein in peripheral nerves. This is an investigational therapy. Article 2: Diagnostic accuracy of late gadolinium enhancement cardiac MRI for coronary artery disease in patients with reduced left ventricular ejection fraction. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40147871 Summary: for coronary artery disease in patients with reduced left ventricular ejection fraction. This study evaluated the diagnostic accuracy of rest cardiac M.R.I. with late gadolinium enhancement for predicting significant coronary artery disease in patients with reduced left ventricular ejection fraction. Results indicate that rest late gadolinium enhancement cardiac M.R.I. can reliably detect significant coronary artery disease in this patient population, aiding in therapeutic decisions such as medical management, device implantation, and revascularization. The finding supports incorporating late gadolinium enhancement cardiac M.R.I. into the diagnostic workup for patients with reduced left ventricular ejection fraction suspected of having coronary artery disease. Article 3: Prognostic impact of neutrophil-to-lymphocyte ratio in patients with and without diabetes mellitus undergoing percutaneous coronary intervention. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40118518 Summary: This retrospective analysis evaluated the prognostic role of the neutrophil-to-lymphocyte ratio in patients with and without diabetes mellitus undergoing percutaneous coronary intervention. The study found that elevated neutrophil-to-lymphocyte ratio was associated with adverse cardiovascular outcomes in both diabetic and non-diabetic patients post-percutaneous coronary intervention. The neutrophil-to-lymphocyte ratio serves as a valuable marker of systemic inflammation and risk stratification in patients undergoing percutaneous coronary intervention, regardless of diabetes status. Article 4: The Role of Lipoprotein(a) in Cardiovascular Risk Stratification: IntegratingLow-density Lipoprotein Cholesterol and Polygenic Risk Scores. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41005599 Summary: This study of over 346,000 UK Biobank participants investigated the interaction between lipoprotein(a), low-density lipoprotein cholesterol, and polygenic risk score in atherosclerotic cardiovascular disease. The research demonstrated that elevated lipoprotein(a) significantly increases cardiovascular risk, even in individuals with well-managed low-density lipoprotein cholesterol and after accounting for polygenic risk. These findings emphasize the importance of measuring lipoprotein(a) levels for comprehensive cardiovascular risk stratification. Article 5: Optimal Intravascular Ultrasound-Guided Percutaneous Coronary Intervention in Patients With Left Main Coronary Artery Disease: The OPTIVUS-Complex PCI Study LMCA Cohort. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41005598 Summary: Study L.M.C.A. Cohort. This prospective, multi-center, single-arm trial (O.P.T.I.V.U.S.

Welcome to Cardiology Today – Recorded September 26, 2025. This episode summarizes 5 key cardiology studies on topics like translational research and young adults. Key takeaway: Antihypertensives Protect Young Hearts. Article Links: Article 1: Transient anticholinergic burden and out-of-hospital cardiac arrest: a case-crossover study. (European heart journal) Article 2: Antihypertensive treatment in young adults and cardiovascular risk: a population-based cohort study. (European heart journal) Article 3: Importance of basic science and research training for the future generation of cardiologists. (European heart journal) Article 4: Drug-coated vs non-drug-coated devices for femoropopliteal artery interventions: long-term outcomes of the SAFE-PAD study. (European heart journal) Article 5: Mineralocorticoid receptor antagonist (MRA) use in UK heart failure care: a national primary care cohort study. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/antihypertensives-protect-young-hearts-09-26-25/ Featured Articles Article 1: Transient anticholinergic burden and out-of-hospital cardiac arrest: a case-crossover study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996095 Summary: This case-crossover study using Taiwan’s National Health Insurance Research Database, involving 173,974 adults, showed that transient increases in anticholinergic burden were associated with a higher risk of out-of-hospital cardiac arrest in middle-aged and older adults. The study utilized case-crossover, case-time-control, and case-case-time-control designs to assess this association. This finding highlights the potential cardiovascular risks associated with anticholinergic medications, particularly in vulnerable populations. Article 2: Antihypertensive treatment in young adults and cardiovascular risk: a population-based cohort study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996093 Summary: This population-based cohort study assessed the impact of antihypertensive treatment adherence on cardiovascular outcomes in young adults (18-39 years) compared to middle-aged adults (40-55 years). The study found evidence of a protective effect of antihypertensive drugs in young adults with good adherence, demonstrating a reduction in both nonfatal and fatal cardiovascular events. These results support the importance of early hypertension management to mitigate long-term cardiovascular risk. Article 3: Importance of basic science and research training for the future generation of cardiologists. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996089 Summary: This article emphasizes the critical role of basic science and research training for future cardiologists to effectively translate preclinical and clinical findings into innovative therapeutic strategies. It highlights the rapid advancements in molecular, cellular biology, and multi-omics studies, necessitating a strong foundation in basic science to understand cardiac disease mechanisms with precision. The authors advocate for integrating rigorous research training into cardiology education to foster innovation and improve patient outcomes. Article 4: Drug-coated vs non-drug-coated devices for femoropopliteal artery interventions: long-term outcomes of the SAFE-PAD study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996087 Summary: study. The S.A.F.E.-P.A.D. study’s final report compared long-term outcomes of drug-coated devices versus non-drug-coated devices in femoropopliteal artery interventions. The study demonstrated that drug-coated devices, including drug-coated balloons and drug-eluting stents, significantly reduced restenosis rates compared to non-drug-coated devices. However, further long-term follow-up is needed to fully address concerns about potential mortality risks associated with drug-coated devices. Article 5: Mineralocorticoid receptor antagonist (MRA) use in UK heart failure care: a national primary care cohort study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40250982 Summary: heart failure care: a national primary care cohort study. This national primary care cohort study evaluated mineralocorticoid receptor antagonist prescription patterns in U.K. patients with heart failure with reduced ejection fraction who met guideline criteria for their use. The study revealed significant underutilization of mineralocorticoid receptor antagonists despite guideline recommendations, highlighting a critical gap in heart failure management. Addressing barriers to mineralocorticoid receptor antagonist prescription and adherence is essential to improve outcomes in this population. Transcript Today’s date is September 26, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Transient anticholinergic burden and out

Welcome to Cardiology Today – Recorded September 26, 2025. This episode summarizes 5 key cardiology studies on topics like vascular remodeling and atrial remodeling. Key takeaway: Sex Differences in A.fib Remodeling Defined. Article Links: Article 1: Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults. (Circulation) Article 2: Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults. (Circulation) Article 3: Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy. (European heart journal) Article 4: EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications. (European heart journal) Article 5: Abnormal electrocardiogram findings in athletes. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/sex-differences-in-a-fib-remodeling-defined-09-26-25/ Featured Articles Article 1: Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40995628 Summary: This study analyzed the clinical implications of anomalous aortic origin of a coronary artery in adults using coronary computed tomography angiography. The study, conducted at an Italian center from 2004-2024, sought to determine outcome predictors. The results detail specific clinical outcomes, which will improve risk stratification for these patients. Article 2: Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40995626 Summary: This retrospective cohort study in Japan evaluated the incidence and cardiovascular outcomes of screening-detected atrial fibrillation in working-age adults. Mandatory E.C.G.s during annual health screenings provided a unique opportunity to identify atrial fibrillation early. The findings reveal the long-term cardiovascular risks associated with screening-detected atrial fibrillation in this population, highlighting the importance of early detection and intervention to prevent stroke and other complications. Article 3: Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996829 Summary: This study investigated sex differences in atrial structural remodeling in patients with non-valvular atrial fibrillation by performing right atrial biopsies and high-density voltage mapping. The research included 282 atrial fibrillation patients and 58 controls undergoing supraventricular tachycardia ablation. The results showed notable histopathological differences between men and women, providing insights into potential sex-specific atrial fibrillation mechanisms and treatment approaches. Article 4: EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996819 Summary: This research investigated the role of the prostaglandin E2 receptor E.P.4 in the pathogenesis of pulmonary arterial hypertension, a condition characterized by abnormal proliferation of pulmonary artery smooth muscle cells. The study aimed to evaluate the potential of E.P.4 as a therapeutic target for pulmonary arterial hypertension. The findings suggest that targeting E.P.4 could offer a novel therapeutic approach for managing pulmonary arterial hypertension by modulating the E.P.4/A.N.X.A.2 axis. Article 5: Abnormal electrocardiogram findings in athletes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40996312 Summary: This article discusses the challenges in interpreting E.C.G.s in athletes, where physiological adaptations can mimic cardiac pathology. It highlights the ongoing efforts to differentiate benign E.C.G. changes from potentially pathological findings requiring further investigation. Addressing diagnostic uncertainties in cardiac assessment of athletes is crucial to avoid unnecessary restrictions and ensure appropriate management of true cardiac conditions. Transcript Today’s date is September 26, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults. This study analyzed the clinical implications of anomalous aortic origin of a coronary artery in adults using coronary computed tomography angiography. The study, conducted at an Italian center from 2004-2024, sought to determine outcome predictors. The results detail specific clinical outcomes, which will improve risk stratification for these patients. Article number two. Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults. This retrospective cohort study in Japan evaluated the incidence and cardiovascular outcomes of scr

Welcome to Cardiology Today – Recorded September 25, 2025. This episode summarizes 5 key cardiology studies on topics like aortic stenosis and mortality. Key takeaway: T.A.V.R.: A.T./E.T. Ratio Improves Outcome Prediction. Article Links: Article 1: Acceleration Time/Ejection Time Ratio Compared to Mean Gradient as a Predictor of Clinical Outcomes Post-TAVR. (JACC. Cardiovascular interventions) Article 2: 1-Year Outcomes of Transfemoral Transcatheter Mitral Valve Replacement With the Eos System: The MISCEND Study. (JACC. Cardiovascular interventions) Article 3: Trends and Late Outcomes in Elderly Patients Undergoing Mitral Valve Interventions in the United States. (JACC. Cardiovascular interventions) Article 4: Percutaneous Coronary Intervention in Multivessel Disease and Infarct-Related Cardiogenic Shock: A DanGer Shock Substudy. (JACC. Cardiovascular interventions) Article 5: Drug-Coated Balloons in the European Registry of Chronic Total Occlusion: The ERCTO Registry. (JACC. Cardiovascular interventions) Full episode page: https://podcast.explainheart.com/podcast/t-a-v-r-a-t-e-t-ratio-improves-outcome-prediction-09-25-25/ Featured Articles Article 1: Acceleration Time/Ejection Time Ratio Compared to Mean Gradient as a Predictor of Clinical Outcomes Post-TAVR. Journal: JACC. Cardiovascular interventions PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40992809 Summary: This study evaluated the acceleration time to ejection time ratio as an alternative hemodynamic measurement to mean gradient for assessing prosthetic valve function after transcatheter aortic valve replacement. The study found that the acceleration time to ejection time ratio may be a more reliable predictor of clinical outcomes post-transcatheter aortic valve replacement compared to mean gradient, potentially reducing the influence of cardiac output and pressure recovery confounders. These findings suggest that acceleration time to ejection time ratio could improve the evaluation of valve performance and risk stratification in patients following transcatheter aortic valve replacement. Article 2: 1-Year Outcomes of Transfemoral Transcatheter Mitral Valve Replacement With the Eos System: The MISCEND Study. Journal: JACC. Cardiovascular interventions PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40992807 Summary: Study. The M.I.S.C.E.N.D. study, a prospective single-arm trial, evaluated the Edwards Eos transcatheter mitral valve replacement system in patients with clinically significant mitral regurgitation at high surgical risk. Results showed that transfemoral transcatheter mitral valve replacement with the Eos system demonstrated acceptable safety and efficacy at one year, offering a potential treatment option for high-risk patients with symptomatic mitral regurgitation. Further research is warranted to compare this approach with other mitral valve interventions. Article 3: Trends and Late Outcomes in Elderly Patients Undergoing Mitral Valve Interventions in the United States. Journal: JACC. Cardiovascular interventions PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40992805 Summary: This study analyzed Medicare claims data to determine trends and outcomes of mitral valve interventions in elderly patients. The study identified utilization trends in mitral valve intervention and factors associated with five-year mortality, offering insights into long-term outcomes for elderly patients undergoing these procedures. These findings help inform clinical decision-making and resource allocation in the management of mitral valve disease in older adults. Article 4: Percutaneous Coronary Intervention in Multivessel Disease and Infarct-Related Cardiogenic Shock: A DanGer Shock Substudy. Journal: JACC. Cardiovascular interventions PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40992803 Summary: This DanGer Shock substudy investigated the association between percutaneous coronary intervention strategy and outcomes in patients with S.T.-segment elevation myocardial infarction-related cardiogenic shock and multivessel disease. The study provides evidence regarding optimal percutaneous coronary intervention strategies in this high-risk population. The results help refine guidelines for percutaneous coronary intervention in patients with S.T.-segment elevation myocardial infarction complicated by cardiogenic shock and multivessel disease. Article 5: Drug-Coated Balloons in the European Registry of Chronic Total Occlusion: The ERCTO Registry. Journal: JACC. Cardiovascular interventions PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40992801 Summary: Registry. This study analyzed data from the European Registry of Chronic Total Occlusion to investigate the use of drug-coated balloons in percutaneous coronary intervention for chronic total occlusions. The findings provide insights into the frequency of use, patient and lesion characteristics, and outcomes associated with drug-coated balloon use in chronic total occlusion P.C.I.. The results support the role of drug-coated

Welcome to Cardiology Today – Recorded September 25, 2025. This episode summarizes 5 key cardiology studies on topics like myotonic dystrophy type 1 and implantable cardiac devices. Key takeaway: P.Y.G.M. Protects Against Myocardial Infarction. Article Links: Article 1: Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023. (Journal of the American College of Cardiology) Article 2: PYGM Protects Against Myocardial Infarction by Enhancing Glycogenolysis and Facilitating Autophagic Flux. (Circulation) Article 3: Contemporary Incidence and Procedural Volume of Transcatheter Aortic Valve Reintervention. (JAMA cardiology) Article 4: Electrocardiogram vs Electrophysiological Study and Major Conduction Delays in Myotonic Dystrophy Type 1. (JAMA cardiology) Article 5: Effects of Glucagon-Like Peptide 1 Receptor Agonist Initiation in Patients With Heart Failure With Reduced Ejection Fraction and Implantable Cardiac Devices. (JACC. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/p-y-g-m-protects-against-myocardial-infarction-09-25-25/ Featured Articles Article 1: Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40990886 Summary: This global analysis of cardiovascular disease burden from 1990 to 2023 reveals a continued increase in most countries, driven by modifiable risk factors, population growth, and aging. The study, encompassing 18 subdiseases and 12 risk factors, highlights the urgent need for targeted interventions to mitigate the growing impact of cardiovascular diseases worldwide. The research underscores that cardiovascular diseases remain a leading cause of mortality and disability. Article 2: PYGM Protects Against Myocardial Infarction by Enhancing Glycogenolysis and Facilitating Autophagic Flux. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40988610 Summary: Protects Against Myocardial Infarction by Enhancing Glycogenolysis and Facilitating Autophagic Flux. This research demonstrates that muscle glycogen phosphorylase, an enzyme crucial for cardiac energy metabolism, protects against myocardial infarction by enhancing glycogenolysis and promoting autophagic flux. Analyzing cardiac tissues and plasma from myocardial infarction patients, the study found that muscle glycogen phosphorylase deficiency exacerbates myocardial infarction, while its replenishment confers protection. These findings suggest that muscle glycogen phosphorylase could be a potential therapeutic target for myocardial infarction. Article 3: Contemporary Incidence and Procedural Volume of Transcatheter Aortic Valve Reintervention. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40991268 Summary: This retrospective analysis of transcatheter aortic valve replacement reinterventions, including redo transcatheter aortic valve replacement and transcatheter aortic valve replacement explant, from 2012 to June 2024, provides contemporary data on procedural incidence and volume. The study addresses the gap in data regarding the frequency of these reinterventions, offering insights into the evolving landscape of aortic valve replacement procedures. The data are crucial for assessing the long-term outcomes and management of patients undergoing transcatheter aortic valve replacement. Article 4: Electrocardiogram vs Electrophysiological Study and Major Conduction Delays in Myotonic Dystrophy Type 1. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40991257 Summary: This study investigates the utility of electrocardiogram findings versus electrophysiological study results in predicting major conduction delays in myotonic dystrophy type 1 patients. Comparing E.C.G. parameters such as P.R. interval and Q.R.S. duration with His-ventricular interval during electrophysiological study, the research aims to refine guidelines for pacemaker implantation in asymptomatic patients at risk of sudden cardiac death. The findings will help clinicians better identify patients who would benefit from prophylactic pacing. Article 5: Effects of Glucagon-Like Peptide 1 Receptor Agonist Initiation in Patients With Heart Failure With Reduced Ejection Fraction and Implantable Cardiac Devices. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40992090 Summary: This study analyzes the effects of glucagon-like peptide 1 receptor agonists on device-related rhythm parameters in patients with Heart Failure with Reduced Ejection Fraction and implanted cardiac devices. By monitoring data from these devices, the researchers aim to determine if glucagon-like peptide 1 receptor agonists induce deleterious effects on heart rate or increase arrhythmic events in this vulnerable population. Understanding these effects is crucial for t

Welcome to Cardiology Today – Recorded September 24, 2025. This episode summarizes 5 key cardiology studies on topics like systolic blood pressure and Heart Failure with Preserved Ejection Fraction. Key takeaway: Height Drives Hypertension in Older Women. Article Links: Article 1: Height May Explain Sex Differences in Systolic Blood Pressure in Older Adults. (Hypertension (Dallas, Tex. : 1979)) Article 2: Long-Term Impact of Platelet Reactivity and Clinical Risk on Clinical Outcomes in Patients With Coronary Artery Disease: Analysis of the PTRG-DES Registry. (Circulation. Cardiovascular interventions) Article 3: Transpulmonary Proteome Gradients Identify Pathways Involved in Pulmonary Vascular Disease Due To Heart Failure. (Circulation. Heart failure) Article 4: Nationwide implementation of heart failure therapies: National Heart Failure Center Accreditation Program (HF-CAP) in China. (European journal of heart failure) Article 5: Dynamic tricuspid regurgitation in heart failure with preserved ejection fraction. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/height-drives-hypertension-in-older-women-09-24-25/ Featured Articles Article 1: Height May Explain Sex Differences in Systolic Blood Pressure in Older Adults. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40977399 Summary: This study analyzed data from the National Health and Nutrition Examination Surveys, examining older women and men with hypertension. The analysis suggests that differences in height contribute to higher systolic blood pressure values in older women compared to men, potentially explaining lower hypertension control rates in women. These findings highlight the importance of considering height when managing hypertension in older adults, especially in women. Article 2: Long-Term Impact of Platelet Reactivity and Clinical Risk on Clinical Outcomes in Patients With Coronary Artery Disease: Analysis of the PTRG-DES Registry. Journal: Circulation. Cardiovascular interventions PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40977391 Summary: Registry. This study from the P.T.R.G.-D.E.S. registry assessed the interaction between platelet reactivity and clinical risk, as determined by the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention, on clinical outcomes after percutaneous coronary intervention. The results showed that high platelet reactivity, combined with high clinical risk scores, was associated with increased adverse clinical events in patients with coronary artery disease treated with drug-eluting stents. This suggests that tailoring antiplatelet therapy based on both platelet function and clinical risk assessment could improve outcomes after percutaneous coronary intervention. Article 3: Transpulmonary Proteome Gradients Identify Pathways Involved in Pulmonary Vascular Disease Due To Heart Failure. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40985143 Summary: This study investigated transpulmonary protein gradients in patients with Heart Failure with Reduced Ejection Fraction to identify mediators of pulmonary vascular disease. Proteomic analysis revealed distinct protein signatures associated with pulmonary vascular disease development in the setting of heart failure. The identified pathways may represent potential therapeutic targets for preventing or treating pulmonary vascular disease in patients with heart failure. Article 4: Nationwide implementation of heart failure therapies: National Heart Failure Center Accreditation Program (HF-CAP) in China. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40982271 Summary: This study evaluated the impact of the National Heart Failure Center Accreditation Program in China on heart failure therapy implementation. Results indicated that hospitals participating in the accreditation program demonstrated improved adherence to guideline-directed medical therapy for heart failure patients. The nationwide implementation of standardized heart failure care through accreditation programs can lead to better treatment and outcomes. Article 5: Dynamic tricuspid regurgitation in heart failure with preserved ejection fraction. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40977275 Summary: This study investigated the changes in tricuspid regurgitation severity during exercise in patients with Heart Failure with Preserved Ejection Fraction using invasive hemodynamic exercise testing and echocardiography. The study found that tricuspid regurgitation often worsens during exercise in these patients, correlating with hemodynamic changes, reduced cardiopulmonary reserve, and worse prognosis. These findings highlight the importance of assessing dynamic tricuspid regurgitation during exercise in Heart Failure with Preserved Ejection Fraction for risk stratification and management. Tr

Welcome to Cardiology Today – Recorded September 24, 2025. This episode summarizes 5 key cardiology studies on topics like blood pressure and geographic variation. Key takeaway: H.E.G.1’s Role in Blood Pressure Control Revealed. Article Links: Article 1: Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure. (European heart journal) Article 2: Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study. (European heart journal) Article 3: Invasive validation of novel 1D models for computation of coronary fractional flow reserve. (Cardiovascular research) Article 4: Finerenone in diabetic chronic kidney disease-Real-world insights including patients with HFpEF or HFmrEF. (ESC heart failure) Article 5: Geographic region variation in patient characteristics, clinical outcomes and treatment of HFrEF in the VICTORIA trial. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/h-e-g-1s-role-in-blood-pressure-control-revealed-09-24-25/ Featured Articles Article 1: Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40986512 Summary: This study demonstrates that Heart development protein with epidermal growth factor-like domain 1, or H.E.G.1., in endothelial cells is critical for sensing shear stress and regulating vasodilation, directly impacting systemic blood pressure. Phenome-wide association studies showed a strong inverse relationship between endothelial H.E.G.1 levels and cardiovascular risk factors, suggesting that impaired H.E.G.1 function contributes to endothelial dysfunction and hypertension. These findings highlight H.E.G.1 as a potential therapeutic target for managing blood pressure and preventing cardiovascular disease. Article 2: Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40985963 Summary: This case-control study identified transcriptomic biomarkers associated with cardiac disease in childhood cancer survivors, comparing gene expression in 165 survivors with cardiac disease to 165 cardiac disease-free controls. Specific genes were found to be differentially expressed in survivors who developed cardiac complications after cardiotoxic cancer treatments like anthracyclines and heart-directed radiotherapy. The identified biomarkers may help predict and personalize treatment strategies to mitigate cardiac risks in this vulnerable population. Article 3: Invasive validation of novel 1D models for computation of coronary fractional flow reserve. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40985755 Summary: This study assessed the accuracy of five one-dimensional virtual fractional flow reserve, or v.F.F.R., models against invasively measured fractional flow reserve, or F.F.R., for assessing coronary lesions. The one-dimensional models, which incorporate side-branch flow representation, significantly reduce simulation time compared to three-dimensional alternatives. Results showed good agreement and diagnostic accuracy compared to established F.F.R. methods, suggesting that one-dimensional v.F.F.R. models can provide a faster and reliable non-invasive tool for evaluating coronary artery disease. Article 4: Finerenone in diabetic chronic kidney disease-Real-world insights including patients with HFpEF or HFmrEF. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983954 Summary: This study examined the real-world safety and cardiac effects of finerenone in patients with chronic kidney disease and type 2 diabetes, including those with Heart Failure with Preserved Ejection Fraction or Heart Failure with Mid-Range Ejection Fraction. Finerenone, a non-steroidal mineralocorticoid receptor antagonist, demonstrated a reduction in heart failure events and cardiovascular death. The study provides evidence supporting the use of finerenone to improve cardiac outcomes in this high-risk patient population. Article 5: Geographic region variation in patient characteristics, clinical outcomes and treatment of HFrEF in the VICTORIA trial. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40977249 Summary: This analysis of the VICTORIA trial investigates how geographic variations impact patient characteristics, guideline-directed medical therapy, and clinical outcomes in individuals with Heart Failure with Reduced Ejection Fraction. The study evaluated the influence of regional differences on the effectiveness of vericiguat compared to placebo. The findings underscore the need to consider geographic factors when tailoring heart failure management strategies to optimize patient care and outcomes. Transcript Today’s date is September 24, 2025. Welcome to Cardiology Today. Here ar

Welcome to Cardiology Today – Recorded September 23, 2025. This episode summarizes 5 key cardiology studies on topics like MELOS RELOADED and Pacemaker. Key takeaway: Triglycerides Drive Aneurysm Rupture Risk. Article Links: Article 1: Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models. (Circulation) Article 2: Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study. (European heart journal) Article 3: Epidemiology and risk factors for constrictive pericarditis in a statewide Australian cohort of patients with pericardial disease. (The Canadian journal of cardiology) Article 4: Self-Expanding Intra-Annular Transcatheter Aortic Valve Replacement System in Patients with Severely Calcified Aortic Valve. (The Canadian journal of cardiology) Article 5: Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/triglycerides-drive-aneurysm-rupture-risk-09-23-25/ Featured Articles Article 1: Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40762097 Summary: This study used Mendelian randomization and experimental models to investigate the relationship between triglycerides and abdominal aortic aneurysm. The findings suggest elevated triglyceride levels causally contribute to abdominal aortic aneurysm development and rupture, identifying a potential therapeutic target. This indicates that lowering triglycerides could be a pharmacological strategy to prevent abdominal aortic aneurysm progression. Article 2: Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40977097 Summary: The MELOS RELOADED study, a multicenter European registry, compared left bundle branch area pacing to right ventricular pacing in patients with atrioventricular block. Results demonstrated no significant difference in long-term survival between the two pacing strategies. Further analysis is needed to identify subgroups that may benefit more from left bundle branch area pacing. Article 3: Epidemiology and risk factors for constrictive pericarditis in a statewide Australian cohort of patients with pericardial disease. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983194 Summary: This retrospective cohort study analyzed hospitalized patients with pericardial disease in New South Wales, Australia, from 2004 to 2021 to identify risk factors for constrictive pericarditis. The study defined the epidemiology and predictors of constrictive pericarditis utilizing multivariable logistic regression to determine risk factors within this large population-based cohort. The results illuminate potential targets for early intervention and prevention of this rare but serious complication. Article 4: Self-Expanding Intra-Annular Transcatheter Aortic Valve Replacement System in Patients with Severely Calcified Aortic Valve. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983190 Summary: This retrospective, multicenter study evaluated the impact of severe aortic valve calcification on outcomes following transcatheter aortic valve replacement using self-expanding intra-annular transcatheter heart valves. The study revealed that severe aortic valve calcification does not significantly impact procedural or clinical outcomes in patients undergoing transcatheter aortic valve replacement with Portico or Navitor transcatheter heart valves. This suggests that these valves are safe and effective even in patients with heavily calcified valves. Article 5: Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40983185 Summary: This study investigated the role of interventricular septal thickness, measured via pre-procedural computed tomography, in predicting the need for permanent pacemaker implantation after transcatheter aortic valve replacement. The findings indicate that lower interventricular septal thickness is a predictor of permanent pacemaker implantation post-transcatheter aortic valve replacement. Integrating interventricular septal thickness into pre-procedural assessment may improve risk stratification and patient selection. Transcript Today’s date is September 23, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneur

Welcome to Cardiology Today – Recorded September 23, 2025. This episode summarizes 5 key cardiology studies on topics like risk stratification and phosphorylation. Key takeaway: Heart Failure Risk: The Power of Genetic Scores. Article Links: Article 1: Intensive vs Conventional Intraoperative Blood Pressure Management on Cardiovascular Events After Major Abdominal Surgery: The BP-CARES Randomized Trial. (Journal of the American College of Cardiology) Article 2: A Polygenic Risk Score to Predict Incident Heart Failure Across the Spectrum of Cardiovascular Risk. (Journal of the American College of Cardiology) Article 3: Outcomes of Percutaneous Mechanical Aspiration in Right-Sided Infective Endocarditis: A Multicenter Registry. (Journal of the American College of Cardiology) Article 4: Causes of Myocardial Infarction in Younger Patients: Troponin-Elevation in Persons ≤65 Years Old in Olmsted County. (Journal of the American College of Cardiology) Article 5: G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/heart-failure-risk-the-power-of-genetic-scores-09-23-25/ Featured Articles Article 1: Intensive vs Conventional Intraoperative Blood Pressure Management on Cardiovascular Events After Major Abdominal Surgery: The BP-CARES Randomized Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40962376 Summary: This randomized trial evaluated intensive versus conventional intraoperative blood pressure management during major abdominal surgery and its impact on cardiovascular events. The study found no significant difference in the incidence of cardiovascular complications within 30 days between the intensive and conventional blood pressure management groups, suggesting that targeting higher intraoperative blood pressure does not reduce postoperative cardiovascular events after major abdominal surgery. These findings indicate that current conventional blood pressure management strategies are adequate for preventing cardiovascular complications in this setting. Article 2: A Polygenic Risk Score to Predict Incident Heart Failure Across the Spectrum of Cardiovascular Risk. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40864011 Summary: This study investigated the ability of a heart failure polygenic risk score to predict new-onset heart failure across a spectrum of cardiovascular risk. Results showed that individuals in the highest quintile of the polygenic risk score had a significantly increased risk of developing heart failure, even after adjusting for clinical risk factors. The polygenic risk score improved risk stratification for heart failure, suggesting it could be a useful tool for identifying individuals who would benefit from early preventative interventions. Article 3: Outcomes of Percutaneous Mechanical Aspiration in Right-Sided Infective Endocarditis: A Multicenter Registry. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40864007 Summary: This multi-center registry assessed the early clinical outcomes and safety of percutaneous mechanical aspiration in patients with right-sided infective endocarditis. The study demonstrated that percutaneous mechanical aspiration was associated with a high rate of clinical success in removing infected vegetations. However, there were also notable rates of in-hospital mortality and major adverse events, indicating the need for careful patient selection and further research to optimize this intervention. Article 4: Causes of Myocardial Infarction in Younger Patients: Troponin-Elevation in Persons ≤65 Years Old in Olmsted County. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40864006 Summary: This study examined the causes and outcomes of myocardial infarction in patients aged 65 years or younger within a defined community. The research revealed that a significant proportion of myocardial infarctions in this younger population were attributed to non-atherothrombotic causes, including myocardial infarction with non-obstructive coronary arteries, spontaneous coronary artery dissection, and myocarditis. These findings underscore the importance of considering a broad differential diagnosis when evaluating younger patients presenting with elevated troponin levels. Article 5: G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40772312 Summary: This study investigated the role of G protein-coupled receptor kinase 3 in diabetic heart injury, using both human and mouse models. Researchers discovered that G protein-coupled receptor kinase 3 exac

Welcome to Cardiology Today – Recorded September 22, 2025. This episode summarizes 5 key cardiology studies on topics like Left Ventricular Dysfunction and Genetic Testing. Key takeaway: Contractile Reserve Predicts T.A.V.I. Success. Article Links: Article 1: Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study. (International journal of cardiology) Article 2: The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI. (International journal of cardiology) Article 3: Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling. (International journal of cardiology) Article 4: Stroke Recurrence and Pregnancy Outcomes in the Subsequent Pregnancies After Maternal Ischemic Stroke. (Stroke) Article 5: Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The ES-EASY project. (Stroke) Full episode page: https://podcast.explainheart.com/podcast/contractile-reserve-predicts-t-a-v-i-success-09-22-25/ Featured Articles Article 1: Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976358 Summary: This prospective study of over six thousand individuals revealed that obesity and inactivity are the strongest risk factors for developing heart failure. The study used latent class analysis to identify multimorbidity patterns and found that clusters with obesity and inactivity were most strongly associated with incident heart failure, regardless of ejection fraction. These findings underscore the critical importance of lifestyle interventions targeting obesity and physical activity to reduce heart failure risk. Article 2: The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976357 Summary: This multicenter registry study evaluated the prognostic value of contractile reserve, assessed by dobutamine stress echocardiography, in patients with left ventricular dysfunction undergoing transcatheter aortic valve implantation. The presence of contractile reserve was significantly associated with improved left ventricular ejection fraction recovery and better clinical outcomes post-transcatheter aortic valve implantation. These results suggest that dobutamine stress echocardiography can help select appropriate candidates for transcatheter aortic valve implantation among patients with severe left ventricular dysfunction. Article 3: Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976356 Summary: This meta-regression analysis of ninety-seven articles investigated the influence of age and instrumental parameters on head-up tilt testing outcomes in patients with suspected vasovagal syncope. The analysis found that age and the use of isoproterenol potentiation significantly affected the positivity rate of head-up tilt testing. These findings highlight the importance of considering patient age and provocation protocols when interpreting head-up tilt testing results for syncope diagnosis. Article 4: Stroke Recurrence and Pregnancy Outcomes in the Subsequent Pregnancies After Maternal Ischemic Stroke. Journal: Stroke PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970275 Summary: This study examined subsequent pregnancies in women with a history of ischemic stroke during pregnancy or the puerperium. Results showed a significant risk of stroke recurrence in subsequent pregnancies, as well as increased risks of other complications. The study underscores the need for careful secondary prevention strategies and close monitoring during subsequent pregnancies in women with prior maternal ischemic stroke. Article 5: Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The ES-EASY project. Journal: Stroke PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970272 Summary: This retrospective observational cohort study assessed the value of systematic genetic analyses in young adults with cryptogenic stroke. The project aimed to estimate the frequency of genetic disorders in these patients. The study is ongoing, but preliminary data suggests that genetic testing may uncover rare causes of stroke in young individuals, potentially influencing treatment strategies. Transcript Today’s date is September 22, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study. This prospective study of over six thousand individuals revealed that obesity and inactivit

Welcome to Cardiology Today – Recorded September 22, 2025. This episode summarizes 5 key cardiology studies on topics like ventricular tachycardia and atrial fibrillation. Key takeaway: C.M.R. Improves I.C.D. Decisions in Sarcoidosis. Article Links: Article 1: Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study. (European heart journal) Article 2: Prediction of ventricular arrhythmic outcomes in suspected cardiac sarcoidosis: a comparison of cardiovascular magnetic resonance phenotyping vs. societal recommendations for implantable cardioverter-defibrillator placement. (European heart journal) Article 3: Impact of alternative efficacy endpoint definitions on reported outcomes after ablation of paroxysmal atrial fibrillation – insights from the COMPARE-CRYO study using continuous rhythm monitoring. (Heart rhythm) Article 4: Ventricular Tachycardia Substrate Mapping with Cardiac Computed Tomography and Cardiac Magnetic Resonance Imaging: Head-to-head Comparison of Two Clinically Available Post-processing Platforms. (Heart rhythm) Article 5: Outcome of Functional Mitral Regurgitation Associated with Heart Failure with Mildly Reduced or Preserved Ejection Fraction. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/c-m-r-improves-i-c-d-decisions-in-sarcoidosis-09-22-25/ Featured Articles Article 1: Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40641372 Summary: This Danish registry study assessed the 10-year risk of first-time infective endocarditis following mitral valve replacement or repair compared to patients at moderate risk. Results showed that mitral valve replacement carried a significantly higher risk of infective endocarditis than mitral valve repair over the long term. This data underscores the importance of considering infective endocarditis risk when choosing between mitral valve replacement and repair. Article 2: Prediction of ventricular arrhythmic outcomes in suspected cardiac sarcoidosis: a comparison of cardiovascular magnetic resonance phenotyping vs. societal recommendations for implantable cardioverter-defibrillator placement. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40400457 Summary: societal recommendations for implantable cardioverter-defibrillator placement. This study compared cardiovascular magnetic resonance imaging phenotyping to societal guidelines for predicting ventricular arrhythmias in patients with suspected cardiac sarcoidosis, aiming to improve implantable cardioverter defibrillator placement. The findings suggest that cardiovascular magnetic resonance imaging phenotyping may offer superior accuracy in predicting long-term ventricular arrhythmic events compared to guideline-based recommendations. This may lead to more informed decisions regarding implantable cardioverter defibrillator implantation in this complex patient population. Article 3: Impact of alternative efficacy endpoint definitions on reported outcomes after ablation of paroxysmal atrial fibrillation – insights from the COMPARE-CRYO study using continuous rhythm monitoring. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976542 Summary: This sub-analysis of the COMPARE-CRYO study examined how different endpoint definitions impact the assessment of atrial fibrillation ablation success, utilizing continuous rhythm monitoring data from implantable cardiac monitors. The study demonstrated that varying the endpoint definitions based on atrial fibrillation burden, duration, or episode frequency significantly alters the reported success rates post ablation. These findings highlight the importance of standardized endpoint definitions for atrial fibrillation ablation studies and their impact on healthcare utilization. Article 4: Ventricular Tachycardia Substrate Mapping with Cardiac Computed Tomography and Cardiac Magnetic Resonance Imaging: Head-to-head Comparison of Two Clinically Available Post-processing Platforms. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976541 Summary: This study provides a head-to-head comparison of two post-processing platforms, ADAS 3D L.V. and inHEART, for ventricular tachycardia substrate mapping using cardiac computed tomography and late-gadolinium enhanced cardiac magnetic resonance imaging in patients undergoing ventricular tachycardia ablation. The research compared substrate models derived from both modalities using both platforms. The study aims to optimize ventricular tachycardia ablation guidance using cardiac imaging. Article 5: Outcome of Functional Mitral Regurgitation Associated with Heart Failure with Mildly Reduced or Preserved Ejection Fraction. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40976391 Summar

Welcome to Cardiology Today – Recorded September 21, 2025. This episode summarizes 5 key cardiology studies on topics like major adverse cardiovascular events and hypertension screening. Key takeaway: Race Affects Outcomes After C.A.B.G.. Article Links: Article 1: Diagnostic Performance of Unattended Automated Office Blood Pressure Measurement for Hypertension Screening Among People With and Without HIV. (Journal of the American Heart Association) Article 2: Influence of Sex and Race or Ethnicity on Major Adverse Cardiovascular Outcomes Following Coronary Artery Bypass Surgery in a Large Integrated Health Care System. (Journal of the American Heart Association) Article 3: Stroke Caregiver Needs in a Population-Based Study. (Journal of the American Heart Association) Article 4: Plasma Phenylacetylglutamine and Cognitive Impairment After Ischemic Stroke. (Journal of the American Heart Association) Article 5: Long-Term Estimated Physical Activity Patterns From Youth to Middle Age and Left Ventricular Structure and Function: A 30-Year Longitudinal Study. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/race-affects-outcomes-after-c-a-b-g-09-21-25/ Featured Articles Article 1: Diagnostic Performance of Unattended Automated Office Blood Pressure Measurement for Hypertension Screening Among People With and Without HIV. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970526 Summary: Unattended automated office blood pressure measurement effectively screens for hypertension in both people with and without H.I.V., using twenty-four hour ambulatory blood pressure monitoring as the reference standard. The study highlights the utility of automated office blood pressure as a practical tool for hypertension detection in diverse populations, including those with H.I.V.. This method offers a standardized approach to improve hypertension screening in clinical settings. Article 2: Influence of Sex and Race or Ethnicity on Major Adverse Cardiovascular Outcomes Following Coronary Artery Bypass Surgery in a Large Integrated Health Care System. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970524 Summary: This retrospective study of patients undergoing coronary artery bypass grafting showed that non-white race or ethnicity was associated with a higher risk of major adverse cardiovascular events at one year and up to twelve years post-surgery. However, sex was not independently associated with increased major adverse cardiovascular events after coronary artery bypass grafting. These findings underscore the importance of addressing racial and ethnic disparities in long-term cardiovascular outcomes following coronary artery bypass grafting. Article 3: Stroke Caregiver Needs in a Population-Based Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970522 Summary: This population-based study in Nueces County, Texas, examined the needs of stroke survivors and their caregivers, revealing significant unmet needs and limited awareness of available services. Informal caregivers play a crucial role in stroke recovery, yet they experience substantial burdens. Addressing these unmet needs through improved service awareness and access is essential for enhancing both caregiver well-being and patient outcomes. Article 4: Plasma Phenylacetylglutamine and Cognitive Impairment After Ischemic Stroke. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970520 Summary: This multicenter cohort study investigated the association between plasma phenylacetylglutamine levels and post-stroke cognitive impairment three months after ischemic stroke. Higher levels of plasma phenylacetylglutamine were found to be associated with increased risk of post-stroke cognitive impairment. This suggests that plasma phenylacetylglutamine could potentially serve as a biomarker or therapeutic target for cognitive decline following ischemic stroke. Article 5: Long-Term Estimated Physical Activity Patterns From Youth to Middle Age and Left Ventricular Structure and Function: A 30-Year Longitudinal Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970518 Summary: This thirty-year longitudinal study found that greater cumulative physical activity from young adulthood to middle age is associated with favorable left ventricular structure and function. Sustained physical activity over three decades appears to promote healthy cardiac remodeling, similar to effects observed in elite athletes. These results underscore the importance of maintaining consistent physical activity throughout life for long-term cardiovascular health. Transcript Today’s date is September 21, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Diagnostic P

Welcome to Cardiology Today – Recorded September 21, 2025. This episode summarizes 5 key cardiology studies on topics like hospitalization and hypertensive disorders of pregnancy. Key takeaway: Gestational Diabetes Ups Long-Term Heart Risk. Article Links: Article 1: Arterial Stiffness in Cancer Survivors: The Prognostic Value of Estimated Pulse Wave Velocity in US Cancer Population From the National Health and Nutrition Examination Survey 2009 to 2018. (Journal of the American Heart Association) Article 2: Disparities in Access to Vascular Stroke Imaging and Carotid Revascularization: A Population Study. (Journal of the American Heart Association) Article 3: Enhancing Societal Participation for Stroke Survivors With Cognitive Impairments: A Randomized Controlled Trial. (Journal of the American Heart Association) Article 4: Associations Between Blood Heavy Metal Concentrations and Hypertensive Disorders of Pregnancy in the Japan Environment and Children’s Study. (Journal of the American Heart Association) Article 5: Gestational Diabetes and Incident Hospitalization for Cardiovascular Disease: A Nationwide French Cohort Study. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/gestational-diabetes-ups-long-term-heart-risk-09-21-25/ Featured Articles Article 1: Arterial Stiffness in Cancer Survivors: The Prognostic Value of Estimated Pulse Wave Velocity in US Cancer Population From the National Health and Nutrition Examination Survey 2009 to 2018. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970534 Summary: This study found that arterial stiffness, measured by estimated pulse wave velocity, is significantly associated with both all-cause and cardiovascular death in cancer survivors. The research identified an optimal estimated pulse wave velocity threshold for risk stratification, suggesting that monitoring arterial stiffness could improve outcomes for this vulnerable population. These findings highlight the importance of cardiovascular risk management in cancer survivorship. Article 2: Disparities in Access to Vascular Stroke Imaging and Carotid Revascularization: A Population Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970533 Summary: This population-based study in Alberta, Canada revealed disparities in access to vascular imaging, including computed tomography angiography, magnetic resonance angiography, and ultrasound, for stroke and transient ischemic attack patients. The research also uncovered differences in the utilization of carotid revascularization procedures based on various factors. These findings emphasize the need to address inequities in stroke care access to ensure equitable outcomes. Article 3: Enhancing Societal Participation for Stroke Survivors With Cognitive Impairments: A Randomized Controlled Trial. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970531 Summary: This randomized controlled trial demonstrated that participation-focused strategy training improves societal participation in community-dwelling stroke survivors with executive function impairments. The study enrolled stroke survivors with executive function impairments between January 2019 and March 2023. These results support the implementation of targeted rehabilitation strategies to enhance social reintegration after stroke. Article 4: Associations Between Blood Heavy Metal Concentrations and Hypertensive Disorders of Pregnancy in the Japan Environment and Children’s Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970530 Summary: This study of over 88,000 pregnant women in Japan investigated the association between blood heavy metal concentrations and hypertensive disorders of pregnancy. The research provides a unique perspective in a low-metal-exposure setting and contributes to the understanding of environmental risk factors for pregnancy complications. Further research is needed to clarify specific heavy metal impacts. Article 5: Gestational Diabetes and Incident Hospitalization for Cardiovascular Disease: A Nationwide French Cohort Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970527 Summary: This nationwide cohort study of over 1.4 million women in France found a significant association between gestational diabetes and an increased risk of subsequent hospitalization for cardiovascular disease, including chronic hypertension. The study quantified the timing of gestational diabetes related cardiovascular disease onset, highlighting the long-term cardiovascular risks following gestational diabetes. These findings underscore the importance of cardiovascular risk management in women with a history of gestational diabetes. Transcript Today’s date is September 21, 2025. Welcome to C

Welcome to Cardiology Today – Recorded September 21, 2025. This episode summarizes 5 key cardiology studies on topics like anticoagulation and longitudinal study. Key takeaway: Pulsed Field Ablation Cuts AFib Procedure Time. Article Links: Article 1: Learning Curve and Procedural Efficiency of Zero-Fluoroscopy Pulsed-Field Ablation for Atrial Fibrillation. (Heart rhythm) Article 2: Population-Based Study on the Coexistence of Metabolic Dysfunction-Associated Steatotic Liver Disease and Chronic Kidney Disease. (Journal of the American Heart Association) Article 3: Dynamic Increase of the C2HEST Score in Relation to the Development of Incident Atrial Fibrillation: A Longitudinal Cohort Study. (Journal of the American Heart Association) Article 4: Associations of Immune Cell Subsets With Coronary Artery Calcium Incidence and Progression in the Multi-Ethnic Study of Atherosclerosis. (Journal of the American Heart Association) Article 5: New-Onset Atrial Fibrillation During ST-Segment-Elevation Myocardial Infarction: Risk of Recurrence and Its Clinical Impact During 10 Years of Follow-Up. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/pulsed-field-ablation-cuts-afib-procedure-time-09-21-25/ Featured Articles Article 1: Learning Curve and Procedural Efficiency of Zero-Fluoroscopy Pulsed-Field Ablation for Atrial Fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40975149 Summary: This study compared zero-fluoroscopy radiofrequency ablation and pulsed-field ablation for paroxysmal atrial fibrillation. Pulsed-field ablation demonstrated significantly shorter procedure times and left atrial dwell times compared to radiofrequency ablation, indicating improved procedural efficiency with similar acute outcomes in experienced centers. These findings suggest pulsed-field ablation may offer advantages in workflow and resource utilization without compromising safety in experienced hands. Article 2: Population-Based Study on the Coexistence of Metabolic Dysfunction-Associated Steatotic Liver Disease and Chronic Kidney Disease. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970538 Summary: This study using National Health and Nutrition Examination Survey data from 2007 to 2018 found that coexistence of metabolic dysfunction-associated steatotic liver disease and chronic kidney disease was associated with a significantly increased risk of all-cause mortality compared to either condition alone. The increased mortality risk highlights the importance of identifying and managing both conditions concurrently to improve patient outcomes. Specifically, the hazard ratio for all-cause mortality was significantly elevated when both conditions were present. Article 3: Dynamic Increase of the C2HEST Score in Relation to the Development of Incident Atrial Fibrillation: A Longitudinal Cohort Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970537 Summary: This longitudinal study demonstrated that an increasing C2HEST score, reflecting accumulation of risk factors like coronary artery disease, hypertension, and heart failure, is associated with a heightened risk of developing incident atrial fibrillation. A dynamic approach to risk assessment using the C2HEST score, rather than a one-time evaluation, may improve prediction of atrial fibrillation risk over time. Monitoring changes in C2HEST score components offers a practical way to identify individuals at increasing risk. Article 4: Associations of Immune Cell Subsets With Coronary Artery Calcium Incidence and Progression in the Multi-Ethnic Study of Atherosclerosis. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970536 Summary: This study from the Multi-Ethnic Study of Atherosclerosis found specific immune cell subsets are associated with both the incidence and progression of coronary artery calcium. Increased CD8-positive T cells and decreased naive B cells were associated with a higher likelihood of coronary artery calcium development, while a higher proportion of regulatory T cells was associated with slower coronary artery calcium progression. These findings suggest that immune cell composition may play a role in the development and progression of subclinical atherosclerosis. Article 5: New-Onset Atrial Fibrillation During ST-Segment-Elevation Myocardial Infarction: Risk of Recurrence and Its Clinical Impact During 10 Years of Follow-Up. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970535 Summary: This single-center study showed a high rate of atrial fibrillation recurrence within 10 years among patients who experienced new-onset atrial fibrillation during ST-segment-elevation myocardial infarction. The recurrence of atrial fibrillation was independently associated with increased risks of stro

Welcome to Cardiology Today – Recorded September 20, 2025. This episode summarizes 5 key cardiology studies on topics like artificial intelligence and N-Formylmethionine. Key takeaway: AI Predicts Post-Infarct Arrhythmia Risk. Article Links: Article 1: Explainable Artificial Intelligence-Driven Risk Assessment for Malignant Ventricular Arrhythmia and Mortality in Acute Myocardial Infarction. (The Canadian journal of cardiology) Article 2: Plasma Metabolite N-Formylmethionine Is Associated With Higher Blood Pressure in the Multiethnic HELIUS Cohort and Triggers Vascular Dysfunction. (Hypertension (Dallas, Tex. : 1979)) Article 3: Neutrophil Extracellular Traps and Delayed Cerebral Ischemia in Patients With Subarachnoid Hemorrhage. (Journal of the American Heart Association) Article 4: Rationale and Design of the EPISODE Trial: A Randomized Controlled Trial on the Effect of PCSK9 Inhibitors in Calcific Aortic Valve Stenosis. (Journal of the American Heart Association) Article 5: Left Ventricular Mass-to-Strain Ratio to Predict Change in Left Ventricular Hypertrophy and Prognosis in Hypertensive Heart Disease. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/ai-predicts-post-infarct-arrhythmia-risk-09-20-25/ Featured Articles Article 1: Explainable Artificial Intelligence-Driven Risk Assessment for Malignant Ventricular Arrhythmia and Mortality in Acute Myocardial Infarction. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972895 Summary: This study developed artificial intelligence models to predict malignant ventricular arrhythmia and in-hospital death after acute myocardial infarction using data from 4,471 patients. The models demonstrated predictive performance, suggesting artificial intelligence could be a valuable tool for risk stratification in patients post myocardial infarction. Further prospective validation is needed to confirm these findings. Article 2: Plasma Metabolite N-Formylmethionine Is Associated With Higher Blood Pressure in the Multiethnic HELIUS Cohort and Triggers Vascular Dysfunction. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40959884 Summary: In a multiethnic cohort study, the plasma metabolite N-Formylmethionine was associated with higher blood pressure. This association suggests a potential link between N-Formylmethionine and vascular dysfunction across diverse ethnic groups. Further research is needed to explore N-Formylmethionine as a therapeutic target for hypertension. Article 3: Neutrophil Extracellular Traps and Delayed Cerebral Ischemia in Patients With Subarachnoid Hemorrhage. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970545 Summary: This prospective single-center study investigated the role of neutrophil extracellular traps in delayed cerebral ischemia following subarachnoid hemorrhage. The study found an association between trajectories of neutrophil extracellular trap biomarkers and the occurrence of delayed cerebral ischemia. These findings suggest that neutrophil extracellular traps may be a therapeutic target for preventing delayed cerebral ischemia in patients with subarachnoid hemorrhage. Article 4: Rationale and Design of the EPISODE Trial: A Randomized Controlled Trial on the Effect of PCSK9 Inhibitors in Calcific Aortic Valve Stenosis. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970544 Summary: The EPISODE trial is a randomized controlled trial designed to investigate the effect of Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors on calcific aortic valve stenosis. This trial aims to determine if Proprotein Convertase Subtilisin/Kexin Type 9 inhibition can prevent or delay the progression of calcific aortic valve stenosis, addressing the current lack of effective pharmacological interventions. The trial is ongoing. Article 5: Left Ventricular Mass-to-Strain Ratio to Predict Change in Left Ventricular Hypertrophy and Prognosis in Hypertensive Heart Disease. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970541 Summary: This retrospective study evaluated the left ventricular mass-to-strain ratio as a marker of the clinical course in patients with hypertensive heart disease. The study found that the left ventricular mass-to-strain ratio can predict changes in left ventricular hypertrophy and prognosis in these patients. The findings suggest that the left ventricular mass-to-strain ratio is a valuable tool for risk stratification and monitoring disease progression in hypertensive heart disease. Transcript Today’s date is September 20, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Explainable Artificial Intelligence-Driven Risk Assessment for Malignant Ventricular Arrhythmia and Mortality in Acute Myocardial I

Welcome to Cardiology Today – Recorded September 20, 2025. This episode summarizes 5 key cardiology studies on topics like non-ST segment elevation acute coronary syndrome and machine learning. Key takeaway: TGF-beta Blockade Prevents Heart Scarring?. Article Links: Article 1: Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. (Circulation) Article 2: Role of A2AR-D2R Dimerization and D2R-Biased Signaling in PDE10A-Mediated Cardiac Hypertrophy. (Circulation) Article 3: Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial. (European heart journal) Article 4: Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acute coronary syndromes. (The Canadian journal of cardiology) Article 5: Machine Learning Reveals How Depression Influences Chest Pain Localization and Its Predictive Value for Coronary Artery Disease. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/tgf-beta-blockade-prevents-heart-scarring-09-20-25/ Featured Articles Article 1: Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970279 Summary: This study in mice revealed that fibroblast-specific disruption of transforming growth factor beta signaling leads to the conversion of fibroblasts to adipocytes, causing fatty infiltration in the infarcted heart. The findings suggest that blocking this pathway could potentially reduce adverse remodeling and arrhythmias post myocardial infarction. This provides a novel therapeutic target to prevent lipomatous metaplasia. Article 2: Role of A2AR-D2R Dimerization and D2R-Biased Signaling in PDE10A-Mediated Cardiac Hypertrophy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40970278 Summary: This research demonstrates that phosphodiesterase 10A contributes to pathological cardiomyocyte hypertrophy through A2AR-D2R dimerization and D2R-biased signaling. Inhibiting phosphodiesterase 10A may be a potential therapeutic target for preventing or reversing cardiac hypertrophy. The study clarifies specific signaling pathways modulated by phosphodiesterase 10A. Article 3: Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40973702 Summary: The EAST trial, a randomized controlled trial, evaluated early antiplatelet therapy versus placebo after intravenous thrombolysis in patients with minor stroke. The study found early antiplatelet treatment was safe and effective compared to delayed antiplatelet treatment, with no significant increase in hemorrhagic transformation. These results support earlier initiation of antiplatelet agents in select stroke patients. Article 4: Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acute coronary syndromes. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972897 Summary: This study investigated the association between post procedural parenteral anticoagulation and clinical outcomes in patients with non-ST segment elevation acute coronary syndrome following percutaneous coronary intervention. The findings showed post procedural anticoagulation was not associated with improved outcomes. This reinforces current guideline recommendations against routine post percutaneous coronary intervention anticoagulation in this population. Article 5: Machine Learning Reveals How Depression Influences Chest Pain Localization and Its Predictive Value for Coronary Artery Disease. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972896 Summary: This study used machine learning to analyze the relationship between depression and chest pain localization in predicting coronary artery disease. The results demonstrated that depression influences chest pain characteristics, affecting its predictive value for coronary artery disease. Understanding this relationship may improve cardiovascular risk assessment in patients with depression. Transcript Today’s date is September 20, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Fibroblast-Specific Loss of Transforming Growth Factor Beta Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. This study in mice revealed that fibroblast-specific disruption of transforming growth factor beta signaling leads to the conversion of fibroblasts to adipocytes, causing fatty infiltration in the infarcted heart. The findings suggest that blocking this pathway could potentially reduce adverse remodeling and arrhythmias post myocardial infarction. This provides a novel therapeutic target to prevent lipomatous metaplasia. Article number two. Role of A2AR-D2R Dimerization and D2R-Biased Signaling in Phosphodiest

Welcome to Cardiology Today – Recorded September 19, 2025. This episode summarizes 5 key cardiology studies on topics like Mendelian randomization and DAPA-MI trial. Key takeaway: Inflammation Drives HFpEF Outcomes: The suPAR Story. Article Links: Article 1: Soluble urokinase plasminogen activator receptor and outcomes in HFpEF: A TOPCAT ancillary study. (ESC heart failure) Article 2: Early diagnostic value of novel biomarkers for breast cancer therapy-related cardiac dysfunction. (ESC heart failure) Article 3: Cardiometabolic outcomes with dapagliflozin after myocardial infarction by baseline ejection fraction: DAPA-MI. (ESC heart failure) Article 4: PHD2 Deletion in CD8+ T Cells Worsens TAC-Induced Cardiac Inflammation, Heart Failure, and Pulmonary Remodeling. (Hypertension (Dallas, Tex. : 1979)) Article 5: Blood Pressure and Mortality in Mexico City: A Mendelian Randomization Study. (Hypertension (Dallas, Tex. : 1979)) Full episode page: https://podcast.explainheart.com/podcast/inflammation-drives-hfpef-outcomes-the-supar-story-09-19-25/ Featured Articles Article 1: Soluble urokinase plasminogen activator receptor and outcomes in HFpEF: A TOPCAT ancillary study. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40963190 Summary: This analysis of the TOPCAT trial’s North American cohort found that elevated levels of soluble urokinase plasminogen activator receptor, a marker of inflammation, were associated with increased risk of adverse outcomes in patients with Heart Failure with Preserved Ejection Fraction. Specifically, higher soluble urokinase plasminogen activator receptor levels correlated with a greater risk of cardiovascular death and heart failure hospitalization, suggesting that inflammation, as reflected by soluble urokinase plasminogen activator receptor, plays a significant role in the progression of Heart Failure with Preserved Ejection Fraction. This highlights soluble urokinase plasminogen activator receptor as a potential therapeutic target and prognostic biomarker in this patient population. Article 2: Early diagnostic value of novel biomarkers for breast cancer therapy-related cardiac dysfunction. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40958744 Summary: This meta-analysis of 12 studies investigated the diagnostic utility of several biomarkers for cancer therapy-related cardiac dysfunction in breast cancer patients. The study suggests myeloperoxidase may be a useful biomarker for early detection of cancer therapy-related cardiac dysfunction, while findings regarding growth differentiation factor-15, C-reactive protein, placental growth factor, and galectin-3 were inconclusive. Further research is warranted to validate these findings and explore the potential of myeloperoxidase-guided interventions. Article 3: Cardiometabolic outcomes with dapagliflozin after myocardial infarction by baseline ejection fraction: DAPA-MI. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40958495 Summary: Analyzing data from the DAPA-MI trial, this study explored the impact of dapagliflozin on cardiometabolic outcomes after acute myocardial infarction, stratified by baseline left ventricular ejection fraction. Dapagliflozin improved outcomes, regardless of ejection fraction, reducing the risk of death, hospitalization for heart failure, myocardial infarction, or atrial fibrillation in patients who had experienced myocardial infarction. This supports the use of dapagliflozin for a broad range of patients post myocardial infarction, irrespective of their baseline ejection fraction. Article 4: PHD2 Deletion in CD8+ T Cells Worsens TAC-Induced Cardiac Inflammation, Heart Failure, and Pulmonary Remodeling. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40959903 Summary: This study, using a mouse model with prolyl hydroxylase domain protein 2 deletion in CD8 positive T cells, demonstrated that loss of prolyl hydroxylase domain protein 2 exacerbated cardiac inflammation, heart failure, and pulmonary remodeling induced by transverse aortic constriction. The findings suggest that prolyl hydroxylase domain protein 2 in CD8 positive T cells plays a protective role against cardiac damage by modulating inflammatory responses. This highlights the potential of targeting prolyl hydroxylase domain protein 2 pathways in CD8 positive T cells as a therapeutic strategy for mitigating cardiac inflammation and heart failure. Article 5: Blood Pressure and Mortality in Mexico City: A Mendelian Randomization Study. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40959886 Summary: Using Mendelian randomization analysis of over 125,000 participants in the Mexico City Prospective Study, this research investigated the lifelong effect of blood pressure on mortality. The study revealed that higher systolic blood pressure was causally associated with increased all-cause and ca

Welcome to Cardiology Today – Recorded September 19, 2025. This episode summarizes 5 key cardiology studies on topics like sudden death and cancer. Key takeaway: New TAVR Thrombosis Risk Factors Identified. Article Links: Article 1: Incidence, predictors and outcomes of subclinical valve thrombosis after TAVR in bicuspid aortic valve stenosis. (The American journal of cardiology) Article 2: Real world data: Survival outcomes and risk factors in extracorporeal membrane oxygenation use of cancer patient. (Cardiology) Article 3: Novel double MYH7/MYBPC3 variants in a Chinese family of Hypertrophic Cardiomyopathy with Early-onset and Sudden Death. (Cardiology) Article 4: Sex differences in access to physician care following a new diagnosis of heart failure in the ambulatory setting. (The Canadian journal of cardiology) Article 5: A Primer on Bioprosthetic Mitral Valve Dysfunction. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/new-tavr-thrombosis-risk-factors-identified-09-19-25/ Featured Articles Article 1: Incidence, predictors and outcomes of subclinical valve thrombosis after TAVR in bicuspid aortic valve stenosis. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40967263 Summary: This study of 508 patients found subclinical valve thrombosis, identified via hypo-attenuated leaflet thickening on computed tomography angiography, occurred after transcatheter aortic valve replacement in both bicuspid and tricuspid aortic valves. The study aimed to evaluate the incidence, predictors, and clinical impact of hypo-attenuated leaflet thickening in the two valve types, assessing implications for valve durability and hemodynamics. Further research is needed to determine optimal management strategies for patients with hypo-attenuated leaflet thickening following transcatheter aortic valve replacement. Article 2: Real world data: Survival outcomes and risk factors in extracorporeal membrane oxygenation use of cancer patient. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40966168 Summary: This retrospective study of 342 adult extracorporeal membrane oxygenation patients at a single center investigated survival outcomes and risk factors in cancer patients receiving extracorporeal membrane oxygenation for cardiopulmonary failure. The study aimed to reassess extracorporeal membrane oxygenation’s role in this population given advances in oncology, and to determine prognostic factors for survival. The results will need to be interpreted cautiously due to the retrospective, single-center design. Article 3: Novel double MYH7/MYBPC3 variants in a Chinese family of Hypertrophic Cardiomyopathy with Early-onset and Sudden Death. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40966167 Summary: This study investigated the genetic basis of hypertrophic cardiomyopathy in a three-generation Chinese family with early-onset and sudden death, using high-throughput second-generation sequencing on the proband to identify novel double variants in the MYH7 and MYBPC3 genes. The study highlights the importance of comprehensive genetic testing beyond the proband to identify multiple pathogenic variants that may be missed by traditional Sanger sequencing in family members. Further studies with larger cohorts are required to confirm the pathogenicity of these novel variants and their association with early-onset and sudden death in hypertrophic cardiomyopathy. Article 4: Sex differences in access to physician care following a new diagnosis of heart failure in the ambulatory setting. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40967484 Summary: This population-based, retrospective cohort study of Ontarians aged 40 years and older diagnosed with heart failure in an ambulatory setting from 2009 to 2019 evaluated time intervals between diagnosis and subsequent physician reassessment, as well as all-cause mortality and heart failure hospitalization or emergency department visits. The study aimed to determine if there are gaps in healthcare access and timely follow-up based on sex. Further analysis is needed to determine the specific factors contributing to these differences and to develop strategies to improve access to care for all patients with heart failure. Article 5: A Primer on Bioprosthetic Mitral Valve Dysfunction. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40967483 Summary: This primer article highlights current approaches to evaluating and treating bioprosthetic mitral valve dysfunction, which is an increasing challenge given the growing number of bioprosthetic mitral valve replacements performed. Dysfunction can manifest as structural or non-structural degeneration, necessitating close follow-up and timely re-intervention when necessary. This review offers a clinically focused summary of the complexities involved in manag

Welcome to Cardiology Today – Recorded September 18, 2025. This episode summarizes 5 key cardiology studies on topics like aortic valve stenosis and quality of life. Key takeaway: Systemic RV Impacts TGA Quality of Life. Article Links: Article 1: Quality of Life in Adults with Transposition of the Great Arteries with a Systemic Right or Left Ventricle. (The Canadian journal of cardiology) Article 2: Predictive value of coronary lesion functional assessment using an OCT computational algorithm in the CLIMA study. (International journal of cardiology) Article 3: Cardiovascular comorbidities predict mortality in acute pancreatitis. (International journal of cardiology) Article 4: REdo transcatheter aortic VALVE implantation for the management of transcatheter aortic valve failure: Design and rationale of the REVALVE study. (International journal of cardiology) Article 5: Loop diuretics, heart failure diagnosis and outcome in primary care. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/systemic-rv-impacts-tga-quality-of-life-09-18-25/ Featured Articles Article 1: Quality of Life in Adults with Transposition of the Great Arteries with a Systemic Right or Left Ventricle. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40962221 Summary: This study evaluated quality of life in adults with transposition of the great arteries, including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries, by comparing patients with a systemic right ventricle and those with a systemic left ventricle. The cross-sectional analysis, part of the APPROACH-IS II study, found that overall quality of life was similar between the two groups. However, patients with a systemic right ventricle exhibited lower physical composite scores, indicating poorer physical health compared to those with a systemic left ventricle. Article 2: Predictive value of coronary lesion functional assessment using an OCT computational algorithm in the CLIMA study. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40409498 Summary: This study evaluated the predictive value of coronary lesion functional assessment using optical coherence tomography (OCT) derived optical flow ratio (OFR). The study found that an abnormal optical flow ratio, indicating functional significance of a coronary lesion, was associated with an increased risk of major adverse cardiac events. Furthermore, combining optical flow ratio with plaque morphology improved risk stratification for adverse cardiac events. Article 3: Cardiovascular comorbidities predict mortality in acute pancreatitis. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40403851 Summary: This study investigated the association between cardiovascular comorbidities and mortality in patients hospitalized with acute pancreatitis. Using German nationwide inpatient statistics from 2005 to 2019, the study revealed that pre-existing cardiovascular conditions significantly increased in-hospital mortality in patients with acute pancreatitis. These findings underscore the importance of considering cardiovascular comorbidities when assessing risk and managing patients with acute pancreatitis. Article 4: REdo transcatheter aortic VALVE implantation for the management of transcatheter aortic valve failure: Design and rationale of the REVALVE study. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40393632 Summary: The REVALVE study is a prospective, open-label registry designed to evaluate the feasibility and outcomes of redo transcatheter aortic valve implantation (TAVI) for bioprosthetic valve failure. Enrolling 300 patients across multiple centers in Europe and the Middle East, this study will assess the safety and efficacy of redo transcatheter aortic valve implantation, providing crucial data on this increasingly relevant treatment strategy. The primary endpoint will assess the composite of all-cause mortality, stroke, or rehospitalization for valve-related symptoms at one year. Article 5: Loop diuretics, heart failure diagnosis and outcome in primary care. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40393631 Summary: This study examined heart failure assessment, diagnosis, and outcomes following loop diuretic prescription in primary care settings. Analyzing data from the Clinical Practice Research Datalink in the United Kingdom, the study revealed that a substantial proportion of patients prescribed loop diuretics were not assessed for heart failure prior to or after initiation. Furthermore, the study showed that patients who received heart failure assessment had better outcomes compared to those who did not, highlighting the importance of appropriate assessment and diagnosis in patients receiving loop diuretics. Transcript Toda

Welcome to Cardiology Today – Recorded September 18, 2025. This episode summarizes 5 key cardiology studies on topics like Heart Failure with Preserved Ejection Fraction and critical care. Key takeaway: Retinal Scans Detect Early Coronary Disease. Article Links: Article 1: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. (The New England journal of medicine) Article 2: Is Type 2 Diabetes a Modifiable Risk Factor for the Evolution and Progression of Heart Failure With a Preserved Ejection Fraction? (Journal of the American College of Cardiology) Article 3: First-in-Human Real-Time MR-Guided Ventricular Ablation for Idiopathic Outflow Tract Premature Ventricular Complexes. (JAMA cardiology) Article 4: Prevention of Adverse Cardiovascular Events Using the 23-Valent Pneumococcal Polysaccharide Vaccine: A Randomized Clinical Trial. (JAMA cardiology) Article 5: Subclinical Coronary Atherosclerosis and Retinal Optical Coherence Tomography Angiography. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/retinal-scans-detect-early-coronary-disease-09-18-25/ Featured Articles Article 1: Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40513024 Summary: This international clinical trial found that proportional-assist ventilation with load-adjustable gain factors did not result in a significantly shorter time to successful liberation from mechanical ventilation compared to pressure-support ventilation in critically ill adults. These findings suggest that the routine use of proportional-assist ventilation with load-adjustable gain factors may not provide a clinically meaningful advantage in reducing the duration of mechanical ventilation. Article 2: Is Type 2 Diabetes a Modifiable Risk Factor for the Evolution and Progression of Heart Failure With a Preserved Ejection Fraction? Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40960442 Summary: It posits that both categories are potentially modifiable through interventions targeting glycemic control and weight management, suggesting avenues for preventing or mitigating Heart Failure with Preserved Ejection Fraction in diabetic patients. Article 3: First-in-Human Real-Time MR-Guided Ventricular Ablation for Idiopathic Outflow Tract Premature Ventricular Complexes. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40960845 Summary: This study demonstrated the technical feasibility of real-time magnetic resonance-guided catheter ablation for idiopathic outflow tract premature ventricular complexes in humans. The procedure allowed for direct visualization of cardiac anatomy and lesion formation without radiation exposure, suggesting a promising radiation-free alternative to conventional ablation techniques for ventricular arrhythmias. Article 4: Prevention of Adverse Cardiovascular Events Using the 23-Valent Pneumococcal Polysaccharide Vaccine: A Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40960793 Summary: This randomized clinical trial found that the 23-valent pneumococcal polysaccharide vaccine did not significantly reduce the composite primary outcome of fatal and nonfatal acute coronary syndrome and ischemic stroke in people at increased cardiovascular risk. The study suggests that pneumococcal vaccination is not effective for primary prevention of atherosclerotic cardiovascular events. Article 5: Subclinical Coronary Atherosclerosis and Retinal Optical Coherence Tomography Angiography. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40960791 Summary: This cross-sectional cohort study found an association between reduced retinal vascular density, as measured by optical coherence tomography angiography, and the presence of subclinical coronary atherosclerosis in asymptomatic individuals with elevated cardiovascular risk. These findings suggest that retinal microvasculature assessment may serve as a non-invasive tool for detecting early signs of coronary artery disease. Transcript Today’s date is September 18, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. This international clinical trial found that proportional-assist ventilation with load-adjustable gain factors did not result in a significantly shorter time to successful liberation from mechanical ventilation compared to pressure-support ventilation in critically ill adults. These findings suggest that the routine use of proportional-assist ventilation with load-adjustable gain factors may not provide a clinically meaningful advantage in reducing the duration of mechanical ventilation. Article number two. Is Type 2 Diabetes a Modifiable Risk Factor

Welcome to Cardiology Today – Recorded September 17, 2025. This episode summarizes 5 key cardiology studies on topics like pediatric heart failure and risk factors. Key takeaway: Mavacamten Remodels HCM Long-Term: VALOR-HCM Data. Article Links: Article 1: Long-Term Favorable Cardiac Remodeling in Obstructive Hypertrophic Cardiomyopathy Patients Treated With Mavacamten for up to 128 Weeks: Insights From the VALOR-HCM Trial. (JACC. Cardiovascular imaging) Article 2: Analysis of risk factors for frailty syndrome in elderly patients with acute coronary syndrome and establishment of a nomogram prediction model. (Cardiology) Article 3: Sex differences on the effect of hemoadsorption during cardiac surgery – A REMOVE trial post-hoc analysis. (International journal of cardiology) Article 4: The efficacy and safety of dapagliflozin in pediatric heart failure. (International journal of cardiology) Article 5: Predictive value of left and right atrial strain for the detection of device-detected atrial fibrillation in patients with cryptogenic stroke and implantable cardiac monitor. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/mavacamten-remodels-hcm-long-term-valor-hcm-data-09-17-25/ Featured Articles Article 1: Long-Term Favorable Cardiac Remodeling in Obstructive Hypertrophic Cardiomyopathy Patients Treated With Mavacamten for up to 128 Weeks: Insights From the VALOR-HCM Trial. Journal: JACC. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40956275 Summary: In patients with severely symptomatic obstructive hypertrophic cardiomyopathy eligible for septal reduction therapy, treatment with mavacamten resulted in sustained reductions in left ventricular outflow tract gradients and favorable cardiac remodeling effects over 128 weeks. These findings from the VALOR-HCM trial suggest mavacamten provides a durable, non-invasive option for managing obstructive hypertrophic cardiomyopathy. Article 2: Analysis of risk factors for frailty syndrome in elderly patients with acute coronary syndrome and establishment of a nomogram prediction model. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40947836 Summary: This study retrospectively analyzed elderly patients with acute coronary syndrome to identify risk factors for frailty syndrome. A nomogram prediction model was established based on these risk factors to predict the likelihood of frailty syndrome in elderly acute coronary syndrome patients. Article 3: Sex differences on the effect of hemoadsorption during cardiac surgery – A REMOVE trial post-hoc analysis. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40414542 Summary: A post-hoc analysis of the REMOVE trial, which examined the use of hemoadsorption during cardiac surgery for infective endocarditis, revealed sex-based differences in outcomes. The study aimed to evaluate if there is a sex-specific impact of hemoadsorption during cardiac surgery for infective endocarditis. Article 4: The efficacy and safety of dapagliflozin in pediatric heart failure. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40412628 Summary: This observational study evaluated the efficacy and safety of dapagliflozin in pediatric patients with heart failure. The primary outcome was a composite of worsening heart failure, heart transplantation, and mortality; the study provides initial data on the use of Sodium-Glucose Cotransporter-2 inhibitors in a pediatric population. Article 5: Predictive value of left and right atrial strain for the detection of device-detected atrial fibrillation in patients with cryptogenic stroke and implantable cardiac monitor. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40409500 Summary: This study investigated the relationship between left and right atrial strain parameters, measured by speckle-tracking echocardiography, and the occurrence of device-detected atrial fibrillation in patients with cryptogenic stroke who received implantable cardiac monitors. The findings suggest that atrial strain parameters may help predict the risk of device-detected atrial fibrillation in this population. Transcript Today’s date is September 17, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Long-Term Favorable Cardiac Remodeling in Obstructive Hypertrophic Cardiomyopathy Patients Treated With Mavacamten for up to 128 Weeks: Insights From the VALOR-HCM Trial. In patients with severely symptomatic obstructive hypertrophic cardiomyopathy eligible for septal reduction therapy, treatment with mavacamten resulted in sustained reductions in left ventricular outflow tract gradients and favorable cardiac remodeling effects over 128 weeks. These findings from the VALOR-HCM trial suggest mavacamten provides a durable, non-invasive option for managing obstructive hypertro

Welcome to Cardiology Today – Recorded September 17, 2025. This episode summarizes 5 key cardiology studies on topics like vascular complications and smooth muscle cell proliferation. Key takeaway: Mammogram AI Flags Hidden Heart Disease Risk. Article Links: Article 1: TAX1BP3 Is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia. (Circulation) Article 2: Predicting cardiovascular events from routine mammograms using machine learning. (Heart (British Cardiac Society)) Article 3: Circulating soluble LOX-1 and patient prognosis after an acute coronary syndrome. (Heart (British Cardiac Society)) Article 4: Frailty and Effects of Semaglutide in Obesity-Related HFpEF: Findings From the STEP-HFpEF Program. (JACC. Heart failure) Article 5: PPG-based smartphone application vs usual care for atrial fibrillation screening: A European multicenter randomized trial. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/mammogram-ai-flags-hidden-heart-disease-risk-09-17-25/ Featured Articles Article 1: TAX1BP3 Is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40955569 Summary: This Circulation study found that TAX1BP3, a SUMOylated protein, plays a protective role against neointimal hyperplasia, a major cause of vascular complications after arterial interventions. Overexpression of TAX1BP3 inhibited smooth muscle cell proliferation and migration, key processes in neointima formation, suggesting it could be a therapeutic target. The study highlights the potential of targeting PDZ domain-mediated protein interactions to improve long-term outcomes after vascular procedures. Article 2: Predicting cardiovascular events from routine mammograms using machine learning. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40957672 Summary: Researchers developed a deep learning algorithm to predict cardiovascular risk using routine mammography images. Analysis of mammograms was linked to hospitalization and death databases, showing that the algorithm could identify women at increased risk based on features like breast arterial calcification. This approach offers a novel opportunity to improve cardiovascular risk assessment in women during midlife screening. Article 3: Circulating soluble LOX-1 and patient prognosis after an acute coronary syndrome. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40957671 Summary: This prospective study in Heart found that elevated plasma levels of soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 (sLOX-1) in patients with acute coronary syndrome correlated with increased risk of developing heart failure, major adverse cardiovascular events, and left ventricular dysfunction. Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 levels may serve as a prognostic biomarker to identify high-risk patients after acute coronary syndrome. Targeting Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 could be a novel therapeutic avenue. Article 4: Frailty and Effects of Semaglutide in Obesity-Related HFpEF: Findings From the STEP-HFpEF Program. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40956259 Summary: Analysis of the STEP-Heart Failure with Preserved Ejection Fraction trial showed that semaglutide improved heart failure symptoms, physical limitations, and body weight in patients with obesity-related Heart Failure with Preserved Ejection Fraction, irrespective of frailty status. Semaglutide’s benefits extended to both frail and non-frail patients, suggesting it’s a valuable treatment option for this patient population. The study supports the use of semaglutide to improve outcomes in obese patients with Heart Failure with Preserved Ejection Fraction, even in the presence of frailty. Article 5: PPG-based smartphone application vs usual care for atrial fibrillation screening: A European multicenter randomized trial. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40769446 Summary: A European multicenter randomized trial evaluated the effectiveness of a smartphone application using photoplethysmography (PPG) for atrial fibrillation screening. The study found that the application with early intervention led to significantly higher detection rates of atrial fibrillation compared to the control group. This suggests that smartphone-based photoplethysmography is an effective tool for large-scale atrial fibrillation screening, potentially enabling earlier diagnosis and stroke prevention. Transcript Today’s date is September 17, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. TAX1BP3 Is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia. This Circulation study found

Welcome to Cardiology Today – Recorded September 16, 2025. This episode summarizes 5 key cardiology studies on topics like coronary angiography and Medicare. Key takeaway: Taller Cardiologists Face Higher Radiation Risk. Article Links: Article 1: Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences. (Circulation) Article 2: Shifting Sites of Care in Electrophysiology: Trends and Cost Differences in Device Implantation Procedures Across Ambulatory and Hospital Settings in the Medicare Population. (Heart rhythm) Article 3: Geographic Variation in Cardiometabolic and Lifestyle Risk Factors Across US States, 2011 to 2021. (The American journal of cardiology) Article 4: The Influence of Height on Occupational Radiation Exposure of Interventional Cardiologists During Selective Coronary Angiography Using a Radial Artery Approach. (The American journal of cardiology) Article 5: Risk factor analysis and prediction of acute postoperative lung injury after type A aortic dissection. (Cardiology) Full episode page: https://podcast.explainheart.com/podcast/taller-cardiologists-face-higher-radiation-risk-09-16-25/ Featured Articles Article 1: Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40671674 Summary: This study found that early vascular aging, characterized by specific aortic geometric remodeling, is linked to adverse cardiovascular outcomes. Using three dimensional aortic imaging, researchers identified genetic determinants influencing this aging process and its association with cardiovascular structure and function. The findings suggest that early identification of aortic geometry via imaging could provide a new target for intervention and risk stratification. Article 2: Shifting Sites of Care in Electrophysiology: Trends and Cost Differences in Device Implantation Procedures Across Ambulatory and Hospital Settings in the Medicare Population. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40953741 Summary: This analysis of Medicare data demonstrates a trend toward increased implantation of cardiac electrophysiology devices like pacemakers and implantable cardioverter-defibrillators in ambulatory surgery centers rather than hospital outpatient departments. The study highlights significant Medicare payment differences between these settings, suggesting potential cost savings in ambulatory surgery centers for device implantation procedures. This shift has important implications for healthcare economics and patient access. Article 3: Geographic Variation in Cardiometabolic and Lifestyle Risk Factors Across US States, 2011 to 2021. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40345311 Summary: Analysis of the Behavioral Risk Factor Surveillance System data from 2011 to 2021 reveals substantial geographic variation in cardiometabolic risk factors including diabetes, hypertension, hyperlipidemia and obesity, as well as lifestyle risk factors across United States states. The study demonstrates that these state-based inequities in risk factor burden have persisted over the decade studied, underscoring the need for targeted interventions to address regional disparities in cardiovascular health. These findings emphasize the importance of considering geographic context in public health initiatives. Article 4: The Influence of Height on Occupational Radiation Exposure of Interventional Cardiologists During Selective Coronary Angiography Using a Radial Artery Approach. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40334929 Summary: This retrospective study found that interventional cardiologist height significantly influences occupational radiation exposure during radial artery coronary angiography. Taller operators experienced higher cumulative radiation exposure, even when normalized for dose area product. These findings suggest that adjusting radiation protection strategies based on operator height could mitigate occupational hazards. Article 5: Risk factor analysis and prediction of acute postoperative lung injury after type A aortic dissection. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40947840 Summary: This retrospective study identified independent risk factors for acute lung injury following surgery for type A aortic dissection, including preoperative ventilation time and intraoperative transfusion volume. Based on these risk factors, the researchers developed a predictive model to evaluate the risk of acute lung injury in patients undergoing this procedure. This model can help clinicians identify high-risk patients and implement preventative strategies. Transcript Today’s date is September 16, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Early Vasc

Welcome to Cardiology Today – Recorded September 16, 2025. This episode summarizes 5 key cardiology studies on topics like Abl-tyrosine kinase inhibitor and ponatinib. Key takeaway: Ponatinib Triggers Thrombosis via TNF Signaling. Article Links: Article 1: Safety and Effectiveness of Statins for Primary Prevention in Adults With Type 1 Diabetes: An Emulation. (Journal of the American College of Cardiology) Article 2: Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease. (Journal of the American College of Cardiology) Article 3: Effect of ECMO Flow Variations on Pulmonary Capillary Wedge Pressure in Patients With Cardiogenic Shock. (Journal of the American College of Cardiology) Article 4: TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis. (Circulation) Article 5: Ponatinib, But Not the New Abl-Kinase Inhibitor Asciminib, Activates Platelets, Leukocytes, and Endothelial Cell TNF Signaling to Induce Atherosclerotic Plaque Inflammation, Myocardial Infarction, and Stroke. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/ponatinib-triggers-thrombosis-via-tnf-signaling-09-16-25/ Featured Articles Article 1: Safety and Effectiveness of Statins for Primary Prevention in Adults With Type 1 Diabetes: An Emulation. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40930617 Summary: This study, emulating a target trial, compared statin initiation versus non-initiation in adults with type 1 diabetes mellitus (T1DM) using United Kingdom primary care data. The findings suggest that statin initiation was associated with a lower risk of cardiovascular disease and all-cause mortality in this population, supporting the consideration of statins for primary prevention in adults with type 1 diabetes mellitus. These benefits need to be carefully weighed against the potential for adverse effects within individual patient risk profiles. Article 2: Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40930615 Summary: This study examined angina trajectories following invasive versus conservative strategies for chronic coronary disease using data from the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial. Results showed that while an invasive strategy initially improved angina symptoms, many patients experienced fluctuating symptoms regardless of treatment arm, suggesting that angina management requires ongoing attention beyond the initial treatment strategy. Individual angina patterns highlight the need for personalized and continuous assessment in patients with chronic coronary disease. Article 3: Effect of ECMO Flow Variations on Pulmonary Capillary Wedge Pressure in Patients With Cardiogenic Shock. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40930613 Summary: This study investigated the impact of incremental femoro-femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) flow variations on pulmonary capillary wedge pressure, hemodynamic parameters, and echocardiographic parameters in patients with cardiogenic shock. The results demonstrated that increasing extracorporeal membrane oxygenation flow did not significantly increase pulmonary capillary wedge pressure, suggesting that concerns about flow-induced pulmonary edema may be less warranted than previously thought, supporting the optimization of extracorporeal membrane oxygenation flow to achieve adequate systemic perfusion in cardiogenic shock. Hemodynamic management should be based on comprehensive assessment to optimize patient care. Article 4: TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40799140 Summary: This study elucidates the role of T-box 5 (TBX5) and chromodomain helicase DNA-binding protein 4 (CHD4) in maintaining atrial rhythm homeostasis. It found that TBX5 interacts with CHD4 to regulate atrial cardiomyocyte enhancer accessibility and transcriptional identity, critical for preventing atrial fibrillation. These findings reveal potential therapeutic targets for atrial fibrillation by modulating TBX5 and CHD4 activity to restore normal atrial rhythm. Article 5: Ponatinib, But Not the New Abl-Kinase Inhibitor Asciminib, Activates Platelets, Leukocytes, and Endothelial Cell TNF Signaling to Induce Atherosclerotic Plaque Inflammation, Myocardial Infarction, and Stroke. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40762051 Summary: This research investigated the mechanisms behind ponatinib-induced thrombosis compared to the newer Abl-tyrosine kinase inhibitor asciminib. The study demonstr

Welcome to Cardiology Today – Recorded September 15, 2025. This episode summarizes 5 key cardiology studies on topics like self-expanding transcatheter heart valve and emergency department. Key takeaway: Lead Extraction Cuts CIED Infection Deaths. Article Links: Article 1: Real-World Evidence on Lead Extraction Following Cardiac Implantable Electronic Device (CIED) Infections and Its Association With 1-year Mortality. (The American journal of cardiology) Article 2: Young Adults Undergoing Percutaneous Coronary Intervention for Myocardial Infarction in the United States, 2011 to 2023. (The American journal of cardiology) Article 3: Outcomes of Percutaneous Coronary Interventions Following Transcatheter Aortic Valve Replacement: Insights From the CathPCI Registry. (The American journal of cardiology) Article 4: Impact of Annulus Size on Bioprosthetic Valve Failure after Self-Expanding Transcatheter Heart Valves Replacement. (The American journal of cardiology) Article 5: Implementation of a High-Sensitivity Cardiac Troponin Assay and Diagnostic Protocol for Suspected Acute Coronary Syndrome. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/lead-extraction-cuts-cied-infection-deaths-09-15-25/ Featured Articles Article 1: Real-World Evidence on Lead Extraction Following Cardiac Implantable Electronic Device (CIED) Infections and Its Association With 1-year Mortality. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40379121 Summary: This Australian study showed that lead extraction for cardiac implantable electronic device infections was performed in a minority of patients. Specifically, the study found that patients who underwent lead extraction had significantly lower one-year mortality compared to those who did not, highlighting the importance of complete lead extraction when managing such infections. The findings underscore the need for improved strategies to increase lead extraction rates in patients with cardiac implantable electronic device infections. Article 2: Young Adults Undergoing Percutaneous Coronary Intervention for Myocardial Infarction in the United States, 2011 to 2023. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40354959 Summary: An analysis of young adults aged 18 to 50 years undergoing percutaneous coronary intervention for myocardial infarction, using the TriNetX database, found distinct differences in long-term outcomes between ST-elevation myocardial infarction and non-ST-elevation myocardial infarction. Patients with ST-elevation myocardial infarction had a higher risk of major adverse cardiovascular events, including death, compared to those with non-ST-elevation myocardial infarction. These results emphasize the need for tailored management strategies for young adults based on the type of myocardial infarction. Article 3: Outcomes of Percutaneous Coronary Interventions Following Transcatheter Aortic Valve Replacement: Insights From the CathPCI Registry. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40354958 Summary: This study, using the CathPCI Registry, compared outcomes of percutaneous coronary intervention in patients with and without prior transcatheter aortic valve replacement. The research revealed that patients undergoing percutaneous coronary intervention post-transcatheter aortic valve replacement had higher in-hospital mortality and bleeding complications compared to those without prior transcatheter aortic valve replacement. This indicates that percutaneous coronary intervention following transcatheter aortic valve replacement is associated with increased procedural risks. Article 4: Impact of Annulus Size on Bioprosthetic Valve Failure after Self-Expanding Transcatheter Heart Valves Replacement. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348045 Summary: In this retrospective analysis of patients undergoing transcatheter aortic valve replacement with self-expanding transcatheter heart valves, the study examined the impact of aortic annulus size on patient and valve outcomes. The findings suggest that patients with small aortic annulus have a higher risk of bioprosthetic valve failure compared to those with larger annuli. This data emphasizes the importance of considering aortic annulus size when selecting patients for transcatheter aortic valve replacement with self-expanding valves, and highlights the need for further research into valve durability in patients with smaller annuli. Article 5: Implementation of a High-Sensitivity Cardiac Troponin Assay and Diagnostic Protocol for Suspected Acute Coronary Syndrome. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348043 Summary: This study assessed the impact of implementing a high-sensitivity cardiac troponin I assay and a 0/2-hour diagnostic protocol for suspec

Welcome to Cardiology Today – Recorded September 15, 2025. This episode summarizes 5 key cardiology studies on topics like high-sensitivity cardiac troponin T and emergency department. Key takeaway: Early Rhythm Control Boosts AFib Mental Health. Article Links: Article 1: Revascularisation strategies for non-acute myocardial ischaemic syndromes. (Heart (British Cardiac Society)) Article 2: Early Rhythm Control and Mental Health-Related Hospitalizations in Young and Middle-Aged Atrial Fibrillation Patients. (Heart rhythm) Article 3: Prognostic Implications of High-Sensitivity Cardiac Troponins in Patients With Acute Kidney Injury Without Myocardial Infarction. (The American journal of cardiology) Article 4: Vigorous But Not Moderate Physical Activity Is Associated With Reduced Cardiovascular Disease Risk In Young Hispanic Men. (The American journal of cardiology) Article 5: Indications and Treatment Outcomes of Below-the-Knee Peripheral Artery Interventions in the XLPAD Registry. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/early-rhythm-control-boosts-afib-mental-health-09-15-25/ Featured Articles Article 1: Revascularisation strategies for non-acute myocardial ischaemic syndromes. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40947142 Summary: This Bayesian network meta-analysis compared coronary artery bypass grafting (CABG) versus percutaneous coronary intervention for non-acute myocardial ischemic syndromes, finding no significant difference in mortality between the two revascularization strategies. The study suggests that the choice of revascularization should be based on individual patient characteristics and local expertise, as neither strategy demonstrated a clear survival advantage. Further research is needed to refine patient selection criteria for each approach. Article 2: Early Rhythm Control and Mental Health-Related Hospitalizations in Young and Middle-Aged Atrial Fibrillation Patients. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40946732 Summary: This study of nearly 167,000 atrial fibrillation patients in Korea found that early rhythm control, initiated within one year of diagnosis, significantly reduced mental health-related healthcare utilization in young and middle-aged individuals with preexisting mental health conditions. The findings highlight the potential benefits of early rhythm control strategies in improving mental health outcomes for vulnerable atrial fibrillation patients. This supports proactive management of atrial fibrillation beyond just rate control in this population. Article 3: Prognostic Implications of High-Sensitivity Cardiac Troponins in Patients With Acute Kidney Injury Without Myocardial Infarction. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40412585 Summary: This study demonstrated that elevated high-sensitivity cardiac troponin T (hs-cTnT) levels in emergency department patients with acute kidney injury but without myocardial infarction are associated with a significantly increased risk of adverse outcomes. Specifically, higher hs-cTnT concentrations were independently predictive of mortality and incident dialysis. These findings suggest that hs-cTnT measurement can help risk-stratify acute kidney injury patients in the emergency department, even in the absence of myocardial infarction. Article 4: Vigorous But Not Moderate Physical Activity Is Associated With Reduced Cardiovascular Disease Risk In Young Hispanic Men. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40409577 Summary: This study of young Hispanic men found that vigorous physical activity, but not moderate physical activity, was associated with reduced cardiovascular disease risk as assessed by the Framingham Risk Score. This suggests that higher intensity exercise may be particularly beneficial for cardiovascular health in this population, warranting further investigation into optimal exercise prescriptions. The results highlight the importance of considering exercise intensity when evaluating physical activity’s impact on cardiovascular risk. Article 5: Indications and Treatment Outcomes of Below-the-Knee Peripheral Artery Interventions in the XLPAD Registry. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40381900 Summary: Analysis of the XLPAD registry showed that below-the-knee peripheral artery interventions for symptomatic peripheral artery disease had a freedom from major adverse limb events rate of 55 percent at one year. These real-world outcomes underscore the challenges in treating below-the-knee peripheral artery disease and highlight the need for improved strategies to prevent major adverse limb events such as amputation and revascularization. Further research is required to optimize patient selection and treatment techniques. Transcript Today&

Welcome to Cardiology Today – Recorded September 14, 2025. This episode summarizes 5 key cardiology studies on topics like transcatheter closure and cardiac imaging. Key takeaway: Electrogram Frequency Predicts Ablation Success. Article Links: Article 1: Phenotype-guided risk stratification in anticoagulated atrial fibrillation patients: cluster analysis of the Murcia AF Project III (MAFP-III). (Heart rhythm) Article 2: Comparison of Far-Field and Peak Frequency Electrogram Characteristics at the Earliest Activation Sites during Idiopathic Ventricular Arrhythmias: A novel index to predict ablation success. (Heart rhythm) Article 3: Changes in Myocardial Light Chain Amyloid Burden After Plasma Cell Therapy. (JACC. Cardiovascular imaging) Article 4: Multiple Amplatzer Vascular Plug III implantation-feasible, safe, and effective for paravalvular leak closure: Results from a single-center registry. (The Canadian journal of cardiology) Article 5: Serial quantitative flow ratio measurements of a successfully recanalized coronary chronic total occlusion. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/electrogram-frequency-predicts-ablation-success-09-14-25/ Featured Articles Article 1: Phenotype-guided risk stratification in anticoagulated atrial fibrillation patients: cluster analysis of the Murcia AF Project III (MAFP-III). Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945558 Summary: This prospective study of anticoagulated atrial fibrillation patients identified distinct phenotypic clusters using hierarchical clustering. The clusters were then analyzed for their association with thromboembolic events, major bleeding, major adverse cardiovascular events, cardiovascular death, and all-cause death over two years, providing a framework for phenotype-guided risk stratification in this population. Article 2: Comparison of Far-Field and Peak Frequency Electrogram Characteristics at the Earliest Activation Sites during Idiopathic Ventricular Arrhythmias: A novel index to predict ablation success. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945557 Summary: This retrospective analysis of 111 idiopathic ventricular arrhythmias in 104 patients examined peak frequency analyses of electrograms at the earliest activation site to predict catheter ablation outcomes. The study suggests peak frequency electrogram characteristics can help differentiate near-field from far-field components, potentially improving ablation success by better identifying appropriate ablation targets. Article 3: Changes in Myocardial Light Chain Amyloid Burden After Plasma Cell Therapy. Journal: JACC. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40938234 Summary: This prospective study of 81 patients with biopsy-proven light chain amyloidosis evaluated changes in myocardial amyloid burden following plasma cell-directed chemotherapy using serial cardiac imaging with radiolabeled serum amyloid P component scintigraphy. The study tracked myocardial amyloid fibril burden in patients with and without amyloid cardiomyopathy, seeking to quantify the impact of plasma cell therapy on cardiac amyloid deposits and inform treatment strategies. Article 4: Multiple Amplatzer Vascular Plug III implantation-feasible, safe, and effective for paravalvular leak closure: Results from a single-center registry. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945911 Summary: This retrospective, single-center registry evaluated the feasibility, safety, and efficacy of using multiple Amplatzer ParaValvular Plug III devices for transcatheter paravalvular leak closure. The study demonstrated that this multi-occluder approach is a reasonable alternative to surgical repair, particularly in high-risk patients experiencing heart failure or hemolysis due to paravalvular leaks. Article 5: Serial quantitative flow ratio measurements of a successfully recanalized coronary chronic total occlusion. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945616 Summary: This retrospective study assessed functional results measured by quantitative flow ratio immediately and six months following successful percutaneous coronary intervention of a chronic total occlusion. The study investigated how coronary perfusion changes over time after successful chronic total occlusion percutaneous coronary intervention, which may impact physiological assessment, suggesting QFR can help detect suboptimal results post-procedure. Transcript Today’s date is September 14, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Phenotype-guided risk stratification in anticoagulated atrial fibrillation patients: cluster analysis of the Murcia AF Project III (MAFP-III). This prospective study of anticoagulated atrial fibrillation patients identified distinct phenotypic c

Welcome to Cardiology Today – Recorded September 14, 2025. This episode summarizes 5 key cardiology studies on topics like computed tomography and right ventricle. Key takeaway: Aortic Dilation: New Predictors of Rapid Progression. Article Links: Article 1: Vascular endothelial growth factor inhibitor-induced cardiotoxicity: prospective multimodality assessment incorporating cardiovascular magnetic resonance imaging. (Heart (British Cardiac Society)) Article 2: Synergistic effects of female-specific conditions and genetic risk on cardiometabolic disease: a cohort study. (Heart (British Cardiac Society)) Article 3: Follow-up of incidentally detected mild to moderate ascending aortic dilation and risk factors for rapid progression in a Swedish middle-aged population. (Heart (British Cardiac Society)) Article 4: Percutaneous intramyocardial septal radiofrequency ablation: a novel treatment for drug-refractory non-obstructive hypertrophic cardiomyopathy with severe septal hypertrophy. (Heart (British Cardiac Society)) Article 5: Relationship Between Electrical and Morphological Alterations of the Right Ventricle in Arrhythmogenic Right Ventricular Cardiomyopathy. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/aortic-dilation-new-predictors-of-rapid-progression-09-14-25/ Featured Articles Article 1: Vascular endothelial growth factor inhibitor-induced cardiotoxicity: prospective multimodality assessment incorporating cardiovascular magnetic resonance imaging. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40180444 Summary: This study prospectively evaluated cardiotoxicity in patients receiving vascular endothelial growth factor inhibitors for cancer treatment, utilizing blood pressure monitoring, echocardiography, and cardiac biomarkers. The research aims to define the incidence, time course, and mechanisms of vascular endothelial growth factor inhibitor associated cancer therapy-related cardiac dysfunction and hypertension through a multi-modal approach including cardiovascular magnetic resonance imaging. The study is ongoing and will provide insights into early detection and management of cardiotoxicity in this patient population. Article 2: Synergistic effects of female-specific conditions and genetic risk on cardiometabolic disease: a cohort study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40139682 Summary: This prospective cohort study of over 150,000 women from the United Kingdom Biobank examined the association between female-specific factors like premature menopause, adverse pregnancy outcomes, and early or late menarche, and the occurrence and progression of cardiometabolic disease. The study aims to determine how these factors interact with genetic risk to influence cardiometabolic health in women. Understanding these interactions will help refine risk stratification and prevention strategies for cardiometabolic disease in women. Article 3: Follow-up of incidentally detected mild to moderate ascending aortic dilation and risk factors for rapid progression in a Swedish middle-aged population. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40081936 Summary: This study investigated the progression of incidentally detected mild to moderate ascending aortic dilation in a Swedish population aged 50-65 years. Researchers followed over 5,000 participants to identify risk factors associated with rapid aortic dilation, which can lead to life-threatening aortic syndromes. Identifying these risk factors will refine surveillance strategies and potentially guide preventive interventions for aortic aneurysm. Article 4: Percutaneous intramyocardial septal radiofrequency ablation: a novel treatment for drug-refractory non-obstructive hypertrophic cardiomyopathy with severe septal hypertrophy. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40054888 Summary: This single-arm, open-label study evaluated the safety and effectiveness of percutaneous intramyocardial septal radiofrequency ablation for drug-refractory non-obstructive hypertrophic cardiomyopathy patients with severe septal hypertrophy. Twenty patients underwent the procedure, with follow-up assessments to determine the impact on symptoms and cardiac function. Percutaneous intramyocardial septal radiofrequency ablation offers a new invasive treatment option for this challenging patient population. Article 5: Relationship Between Electrical and Morphological Alterations of the Right Ventricle in Arrhythmogenic Right Ventricular Cardiomyopathy. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945559 Summary: This retrospective study investigated the spatial relationship between low-voltage areas detected during electrophysiological mapping and morphofunctional abnormalities seen on computed tomography imaging in patients with arrhythmogenic right ventricular c

Welcome to Cardiology Today – Recorded September 13, 2025. This episode summarizes 5 key cardiology studies on topics like acute myocardial infarction and digital health. Key takeaway: ATTR Amyloidosis: Missed HF Diagnosis in Minorities. Article Links: Article 1: Approach to the Postmarket Evaluation of Consumer Wearable Technologies. (JAMA cardiology) Article 2: Noninvasive Anatomical and Functional Imaging for Hemodynamic Relevance in Right Coronary Artery Anomalies. (JAMA cardiology) Article 3: Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. (JAMA cardiology) Article 4: Benefit-risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial. (Heart (British Cardiac Society)) Article 5: Long-term outcomes of intravascular ultrasound-guided percutaneous coronary intervention versus coronary artery bypass grafting for multivessel coronary artery disease. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/attr-amyloidosis-missed-hf-diagnosis-in-minorities-09-13-25/ Featured Articles Article 1: Approach to the Postmarket Evaluation of Consumer Wearable Technologies. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40928810 Summary: This article discusses the need for empirical research on the postmarket use of consumer wearable technologies. The Stanford Center for Digital Health organized think tank meetings to develop a framework for evaluating these devices after they have been released to the public. The focus is on gathering data regarding real-world performance, accuracy, and potential impact on patient outcomes. Article 2: Noninvasive Anatomical and Functional Imaging for Hemodynamic Relevance in Right Coronary Artery Anomalies. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40928770 Summary: This study addresses the challenge of assessing the hemodynamic significance of right anomalous aortic origin of a coronary artery. Invasive fractional flow reserve during a dobutamine-atropine volume challenge is the reference standard, but noninvasive imaging modalities are being explored as a less invasive alternative. The research aims to determine if noninvasive imaging can accurately evaluate dynamic compression of the anomalous vessel. Article 3: Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40928765 Summary: This study investigates the prevalence of transthyretin cardiac amyloidosis in older Black and Hispanic individuals with heart failure. The research aims to determine the proportion of heart failure cases in these populations attributable to both wild-type and variant transthyretin cardiac amyloidosis, including the V142I variant common in Black Americans. Understanding this prevalence is crucial for improving diagnosis and treatment in at-risk groups. Article 4: Benefit-risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40908114 Summary: This analysis of the Colchicine and Spironolactone in Patients with Left Ventricular Dysfunction after Myocardial Infarction (CLEAR) trial uses generalized pairwise comparisons to assess the benefit-risk profiles of colchicine and spironolactone in acute myocardial infarction. This method allows for a hierarchical ranking of clinical outcomes, providing a more intuitive understanding of treatment trade-offs compared to composite endpoints. The analysis explores the overall clinical benefit considering different event severities. Article 5: Long-term outcomes of intravascular ultrasound-guided percutaneous coronary intervention versus coronary artery bypass grafting for multivessel coronary artery disease. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40368452 Summary: This post hoc analysis of the Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment Extended Follow-up study compares long-term outcomes of intravascular ultrasound-guided percutaneous coronary intervention versus coronary artery bypass grafting for multivessel coronary artery disease. It seeks to evaluate if intravascular ultrasound-guided percutaneous coronary intervention is comparable to coronary artery bypass grafting in improving long-term clinical outcomes in patients with multivessel disease. The focus is on patients who were treated with either procedure as part of the original clinical trial. Transcript Today’s date is September 13, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Approach to the Postmarket Evaluation of Consumer Wearable Technologies. This article discusses the n

Welcome to Cardiology Today – Recorded September 11, 2025. This episode summarizes 2 key cardiology studies on topics like chronic limb-threatening ischemia and infrapopliteal disease. Key takeaway: Fulminant Myocarditis: Predictors of Mortality Defined. Article Links: Article 1: Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty for Below-the-Knee Peripheral Artery Disease: 2-Year Results From the LIFE-BTK Trial. (Circulation) Article 2: Fulminant myocarditis: outcome predictors in an international cohort study. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/fulminant-myocarditis-predictors-of-mortality-defined-09-11-25/ Featured Articles Article 1: Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty for Below-the-Knee Peripheral Artery Disease: 2-Year Results From the LIFE-BTK Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40927852 Summary: The LIFE-BTK trial demonstrated that, at two years, drug-eluting resorbable scaffolds showed no statistically significant difference in the primary patency rate compared to percutaneous transluminal angioplasty in patients with chronic limb-threatening ischemia undergoing infrapopliteal intervention. While scaffold thrombosis was higher in the drug-eluting resorbable scaffold group, major amputation rates were similar between the two groups. This suggests that while the resorbable scaffold does not improve patency, it also does not increase the risk of limb loss. Article 2: Fulminant myocarditis: outcome predictors in an international cohort study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40928499 Summary: This retrospective study of fulminant myocarditis across 26 European centers identified lymphocytic myocarditis as the most frequent type and revealed distinct clinical courses based on endomyocardial biopsy findings. Predictors of mortality included the need for mechanical circulatory support, particularly extracorporeal membrane oxygenation, and elevated creatinine levels. These findings underscore the importance of early risk stratification and tailored management strategies in fulminant myocarditis. Transcript Today’s date is September 11, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty for Below-the-Knee Peripheral Artery Disease: 2-Year Results From the LIFE-BTK Trial. The LIFE-BTK trial demonstrated that, at two years, drug-eluting resorbable scaffolds showed no statistically significant difference in the primary patency rate compared to percutaneous transluminal angioplasty in patients with chronic limb-threatening ischemia undergoing infrapopliteal intervention. While scaffold thrombosis was higher in the drug-eluting resorbable scaffold group, major amputation rates were similar between the two groups. This suggests that while the resorbable scaffold does not improve patency, it also does not increase the risk of limb loss. Article number two. Fulminant myocarditis: outcome predictors in an international cohort study. This retrospective study of fulminant myocarditis across 26 European centers identified lymphocytic myocarditis as the most frequent type and revealed distinct clinical courses based on endomyocardial biopsy findings. Predictors of mortality included the need for mechanical circulatory support, particularly extracorporeal membrane oxygenation, and elevated creatinine levels. These findings underscore the importance of early risk stratification and tailored management strategies in fulminant myocarditis. Thank you for listening. Don’t forget to subscribe. Keywords chronic limb-threatening ischemia, infrapopliteal disease, amputation, drug-eluting resorbable scaffold, endomyocardial biopsy, mortality, mechanical circulatory support, percutaneous transluminal angioplasty, fulminant myocarditis, lymphocytic myocarditis. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Fulminant Myocarditis: Predictors of Mortality Defined 09/11/25 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded September 10, 2025. This episode summarizes 2 key cardiology studies on topics like Cardiac Troponins and Cardiac Surgery. Key takeaway: Calcium Signature Predicts Post-Op A Fib Risk. Article Links: Article 1: Great debate: the universal definition of myocardial infarction is flawed and should be put to rest. (European heart journal) Article 2: Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/calcium-signature-predicts-post-op-a-fib-risk-09-10-25/ Featured Articles Article 1: Great debate: the universal definition of myocardial infarction is flawed and should be put to rest. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40923895 Summary: The universal definition of myocardial infarction relies on clinical evidence of myocardial ischemia and biomarker evidence of myocardial cell death, primarily cardiac troponins. The authors argue the current universal definition of myocardial infarction is flawed. Article 2: Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40923107 Summary: This study evaluated whether incorporating cytosolic calcium handling measurements with clinical risk factors improves post-operative atrial fibrillation risk prediction. Analyzing data from 558 patients undergoing cardiac surgery, including atrial cardiomyocytes from a subset, integrating calcium handling abnormalities with clinical factors enhanced atrial fibrillation risk prediction after cardiac surgery. Transcript Today’s date is September 10, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Great debate: the universal definition of myocardial infarction is flawed and should be put to rest. The universal definition of myocardial infarction relies on clinical evidence of myocardial ischemia and biomarker evidence of myocardial cell death, primarily cardiac troponins. The authors argue the current universal definition of myocardial infarction is flawed. Article number two. Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation. This study evaluated whether incorporating cytosolic calcium handling measurements with clinical risk factors improves post-operative atrial fibrillation risk prediction. Analyzing data from 558 patients undergoing cardiac surgery, including atrial cardiomyocytes from a subset, integrating calcium handling abnormalities with clinical factors enhanced atrial fibrillation risk prediction after cardiac surgery. Thank you for listening. Don’t forget to subscribe. Keywords Cardiac Troponins, Cardiac Surgery, Myocardial Ischemia, Myocardial Infarction, Cytosolic Calcium Handling, Post-operative Atrial Fibrillation, Atrial Fibrillation. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Calcium Signature Predicts Post-Op A Fib Risk 09/10/25 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded September 09, 2025. This episode summarizes 3 key cardiology studies on topics like Doxorubicin-Induced Cardiomyopathy and Intracellular Receptors. Key takeaway: Targeting Chemo-Induced Cardiotoxicity via CD47. Article Links: Article 1: Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy. (Circulation) Article 2: Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction. (Circulation) Article 3: Unique Role of Intracellular Perinuclear β1-Adrenergic Receptors in Defining Signaling Compartmentation and Pathological Cardiac Remodeling. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/targeting-chemo-induced-cardiotoxicity-via-cd47-09-09-25/ Featured Articles Article 1: Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40808662 Summary: This study used single-nucleus ribonucleic acid sequencing on left ventricular myocardial tissue to compare patients with doxorubicin cardiomyopathy to those with nonischemic cardiomyopathy and nonfailing hearts, finding significant transcriptional changes associated with doxorubicin cardiomyopathy. The analysis identified CD47 as a potential therapeutic target, suggesting that modulating CD47 expression could improve outcomes for patients experiencing chemotherapy-induced cardiotoxicity. These results offer a targeted approach to mitigating the adverse cardiac effects of doxorubicin. Article 2: Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40709455 Summary: This research demonstrated that junctophilin-2, a protein known for regulating calcium signaling in cardiomyocytes, also plays a critical role in cardiac fibroblast activation after myocardial infarction. Specifically, junctophilin-2 regulates store-operated calcium entry in cardiac fibroblasts, driving fibrotic repair and angiogenesis. The study indicates that modulating junctophilin-2 expression or activity in cardiac fibroblasts could be a novel therapeutic strategy to improve myocardial healing and prevent adverse remodeling post-infarction. Article 3: Unique Role of Intracellular Perinuclear β1-Adrenergic Receptors in Defining Signaling Compartmentation and Pathological Cardiac Remodeling. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40665895 Summary: This investigation revealed that intracellular perinuclear beta one adrenergic receptors have a distinct function in regulating cardiac signaling and pathological remodeling, separate from beta adrenergic receptors located on the plasma membrane. The study showed that these intracellular receptors contribute to adverse cardiac remodeling in disease. These findings suggest that targeting intracellular beta one adrenergic receptor signaling may offer a more specific approach to preventing or treating pathological cardiac remodeling compared to traditional beta-blocker therapies. Transcript Today’s date is September 09, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy. This study used single-nucleus ribonucleic acid sequencing on left ventricular myocardial tissue to compare patients with doxorubicin cardiomyopathy to those with nonischemic cardiomyopathy and nonfailing hearts, finding significant transcriptional changes associated with doxorubicin cardiomyopathy. The analysis identified CD47 as a potential therapeutic target, suggesting that modulating CD47 expression could improve outcomes for patients experiencing chemotherapy-induced cardiotoxicity. These results offer a targeted approach to mitigating the adverse cardiac effects of doxorubicin. Article number two. Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction. This research demonstrated that junctophilin-2, a protein known for regulating calcium signaling in cardiomyocytes, also plays a critical role in cardiac fibroblast activation after myocardial infarction. Specifically, junctophilin-2 regulates store-operated calcium entry in cardiac fibroblasts, driving fibrotic repair and angiogenesis. The study indicates that modulating junctophilin-2 expression or activity in cardiac fibroblasts could be a novel therapeutic strategy to improve myocardial healing and prevent adverse remodeling post-infarction. Article number three. Unique Role of Intracellular Perinuclear β1-Adrenergic Receptors in Defining Signal

Welcome to Cardiology Today – Recorded September 09, 2025. This episode summarizes 5 key cardiology studies on topics like race and cardiomyopathy. Key takeaway: Cardiomyopathy Genes Worsen Atrial Fib Risk. Article Links: Article 1: Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation: Results in 18,000 Clinical Trial Participants. (Journal of the American College of Cardiology) Article 2: Incidence of Heart Failure in Asian American, Native Hawaiian, and Other Pacific Islander Populations. (Journal of the American College of Cardiology) Article 3: Racial and Ethnic Differences in Patient Age at First Hospitalization for Heart Failure. (Journal of the American College of Cardiology) Article 4: Influence of Type 2 Diabetes on the Effects of Tirzepatide in Patients With Heart Failure and a Preserved Ejection Fraction With Obesity: A Prespecified Stratification-Based Analysis. (Journal of the American College of Cardiology) Article 5: Transcatheter Aortic Valve Replacement With Balloon- Versus Self-Expandable Bioprostheses for the Treatment of Bicuspid Aortic Valve Stenosis. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/cardiomyopathy-genes-worsen-atrial-fib-risk-09-09-25/ Featured Articles Article 1: Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation: Results in 18,000 Clinical Trial Participants. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40903137 Summary: This study, analyzing over 18,000 patients from Thrombolysis in Myocardial Infarction study group trials, found that individuals with atrial fibrillation (AF) who carry rare pathogenic or likely pathogenic variants in cardiomyopathy genes have a significantly increased risk of adverse outcomes, including all-cause mortality and heart failure hospitalization. The presence of these variants appears to independently worsen prognosis in AF patients, highlighting the potential clinical importance of genetic screening in this population. These findings suggest that targeted management strategies may be warranted for atrial fibrillation patients with cardiomyopathy gene variants. Article 2: Incidence of Heart Failure in Asian American, Native Hawaiian, and Other Pacific Islander Populations. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40903135 Summary: This study investigated the incidence of heart failure across disaggregated Asian American, Native Hawaiian, and Other Pacific Islander groups using data from Kaiser Permanente Northern California and Kaiser Permanente Hawaii from 2012 to 2022. The research revealed substantial differences in heart failure incidence rates among these individual populations, indicating a need for tailored prevention and management strategies rather than treating the group as a monolith. Specifically, Native Hawaiians and Filipinos experienced higher heart failure incidence compared to Chinese and Japanese subgroups. Article 3: Racial and Ethnic Differences in Patient Age at First Hospitalization for Heart Failure. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40903133 Summary: This study, using data from the Get With The Guidelines-Heart Failure registry, examined racial and ethnic differences in age at first hospitalization for heart failure. The analysis revealed that Black patients were, on average, hospitalized for heart failure at a significantly younger age compared to White patients. This disparity remained even after adjusting for social risk factors, suggesting other biological or environmental factors may contribute to the earlier onset of heart failure in Black individuals. Article 4: Influence of Type 2 Diabetes on the Effects of Tirzepatide in Patients With Heart Failure and a Preserved Ejection Fraction With Obesity: A Prespecified Stratification-Based Analysis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40903131 Summary: This prespecified analysis of the SUMMIT trial assessed the impact of type 2 diabetes on the effects of tirzepatide in Heart Failure with Preserved Ejection Fraction patients with obesity. The study found that the benefits of tirzepatide on weight loss and Heart Failure symptoms were consistent regardless of diabetes status. This suggests tirzepatide can be an effective treatment option for obese Heart Failure with Preserved Ejection Fraction patients with or without type 2 diabetes. Article 5: Transcatheter Aortic Valve Replacement With Balloon- Versus Self-Expandable Bioprostheses for the Treatment of Bicuspid Aortic Valve Stenosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40820731 Summary: This multi-center study compared the outcomes of transcatheter aortic valve replacement (TAVR) using balloon-expandable versus self-expandable valves in patients with bi