Cardiology Today

Welcome to Cardiology Today – Recorded December 01, 2025. This episode summarizes 5 key cardiology studies on topics like lipid transport and short-term outcomes. Key takeaway: PE Calculator Predicts Short-Term Outcomes. Article Links: Article 1: Deletion of METTL14, a key methylation regulator, attenuates vascular ageing. (European heart journal) Article 2: Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response. (European heart journal) Article 3: The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. (European heart journal) Article 4: Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes. (European heart journal) Article 5: Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/pe-calculator-predicts-short-term-outcomes-12-01-25/ Featured Articles Article 1: Deletion of METTL14, a key methylation regulator, attenuates vascular ageing. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40758401 Summary: Deletion of methyltransferase-like protein 14 (METTL14) was found to attenuate vascular aging. This suggests that METTL14 plays a role in promoting vascular aging, possibly by influencing inflammation. Modulating METTL14 activity could therefore represent a therapeutic strategy to combat age-related vascular diseases. Article 2: Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40720766 Summary: This study found that excessive glycosylation drives the formation of thoracic aortic aneurysms and dissections (TAADs) through activation of the integrated stress response. The hexosamine biosynthetic pathway was identified as a key contributor to this process in both sporadic and genetic forms of thoracic aortic aneurysm. This mechanistic insight suggests that targeting the hexosamine biosynthetic pathway could offer a therapeutic approach for preventing or treating thoracic aortic aneurysms and related conditions such as Marfan syndrome. Article 3: The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40709729 Summary: Kinesin family member 13B (KIF13B), a macrophage-derived motor protein, was found to enhance MERTK-mediated efferocytosis. This enhancement of efferocytosis, which is the clearance of apoptotic cells, resulted in the prevention of atherosclerosis in mice. The data suggests that KIF13B plays a protective role against atherosclerosis by improving cellular waste removal, indicating its potential as a therapeutic target. Article 4: Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40391731 Summary: A multimarker prognostic calculator was developed to predict short-term outcomes in patients with acute pulmonary embolism (P. E.). This calculator estimates the absolute risk of key outcomes for individual patients, utilizing variables from the simplified Pulmonary Embolism Severity Index and other markers. The study validated the calculator’s performance and compared it to the established European Society of Cardiology (E. S. C.) model for risk stratification in acute pulmonary embolism, providing a tool for targeted interventions. Article 5: Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40259807 Summary: Nuclear receptor Dosage-sensitive sex reversal, adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (Dax1) was found to promote atherosclerosis. This pro-atherogenic effect occurs through the inhibition of lipid transport and suppression of autophagy within macrophages. The study identified Dax1 levels in human atherosclerotic arteries, suggesting Dax1 as a potential pharmacological target for preventing atherosclerosis. Transcript Today’s date is December 01, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Deletion of METTL14, a key methylation regulator, attenuates vascular ageing. Deletion of methyltransferase-like protein 14 (METTL14) was found to attenuate vascular aging. This suggests that METTL14 plays a role in promoting vascular aging, possibly by influencing inflammation. Modulating METTL14 activity could therefore represent a therapeutic strategy to combat age-related vascular diseases. Article number two. Excessive glycosylation drives thoracic aortic aneurysm formation through integra

Welcome to Cardiology Today – Recorded November 30, 2025. This episode summarizes 5 key cardiology studies on topics like alloresponse and Pulmonary Vein Isolation. Key takeaway: Sick Sinus Syndrome Raises Stroke Risk in Low-Risk A. F.. Article Links: Article 1: Donor MHC-specific IgE augments the T and B cell alloresponse in a CD23-dependent manner. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Sick Sinus Syndrome Elevates Stroke Risk in Atrial Fibrillation Patients with Low CHA2DS2-VASC Score. (Heart rhythm) Article 3: The Effect of Pulmonary Vein Isolation on Gastric Motility: Pulsed-field Ablation vs Radiofrequency. (Heart rhythm) Article 4: New Technique to Achieve Total Mitral Isthmus Block: Targeting Masked Epicardial Conductions. (Heart rhythm) Article 5: Prevalence, Spectrum and Outcomes in Patients with Non-Penetrant Long QT Syndrome. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/sick-sinus-syndrome-raises-stroke-risk-in-low-risk-a-f-11-30-25/ Featured Articles Article 1: Donor MHC-specific IgE augments the T and B cell alloresponse in a CD23-dependent manner. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317870 Summary: H. C.-specific IgE augments the T and B cell alloresponse in a C. D. 23-dependent manner. Donor Major Histocompatibility Complex-specific Immunoglobulin E augments both T cell and B cell alloresponses in a C. D. 23-dependent manner. This mechanism indicates that Immunoglobulin E, in addition to its known roles in allergic hypersensitivity, contributes to immune activation relevant to transplant rejection. The presence of donor Major Histocompatibility Complex-specific Immunoglobulin E has been observed in murine transplant models and in human kidney transplant recipients. These findings illuminate a previously unrecognized role for Immunoglobulin E in modulating the alloimmune response, suggesting it influences transplant outcomes. Article 2: Sick Sinus Syndrome Elevates Stroke Risk in Atrial Fibrillation Patients with Low CHA2DS2-VASC Score. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317944 Summary: H. A. 2. D. S. 2. -V. A. S. C. Score. Sick Sinus Syndrome elevates stroke risk specifically in patients with Atrial Fibrillation who have a low C. H. A. 2. D. S. 2. -V. A. S. C. score. This finding indicates that concomitant Sick Sinus Syndrome acts as an independent risk factor for incident ischemic stroke, even in patients considered to be at lower risk by conventional scoring systems. The study, which analyzed a cohort of 24960 patients, suggests that clinicians should consider the presence of Sick Sinus Syndrome when assessing stroke risk in Atrial Fibrillation patients. Therefore, Sick Sinus Syndrome requires careful consideration in comprehensive stroke prevention strategies for this patient population. Article 3: The Effect of Pulmonary Vein Isolation on Gastric Motility: Pulsed-field Ablation vs Radiofrequency. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317943 Summary: Pulsed-field Ablation for Pulmonary Vein Isolation demonstrates a superior safety profile regarding gastric motility compared to Radiofrequency Ablation. Radiofrequency Ablation for Pulmonary Vein Isolation was observed to impair gastric motility due to collateral thermal injury. In contrast, Pulsed-field Ablation, being a nonthermal modality, preferentially affected cardiomyocytes and preserved gastric motility in patients with Atrial Fibrillation. This indicates that Pulsed-field Ablation offers a significant advantage in reducing the risk of gastric motility impairment during Pulmonary Vein Isolation procedures. Article 4: New Technique to Achieve Total Mitral Isthmus Block: Targeting Masked Epicardial Conductions. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317942 Summary: A novel technique effectively achieves total Mitral Isthmus Block by successfully targeting masked epicardial conductions. The study identified that epicardial conduction played a key role in peri-mitral atrial tachycardia recurrence, which was subsequently addressed by this approach. Targeting these previously masked epicardial pathways with Radiofrequency Ablation proved feasible and instrumental in achieving complete and durable Mitral Isthmus Block. This new method provides a crucial advancement for patients undergoing ablation for persistent Atrial Fibrillation. Article 5: Prevalence, Spectrum and Outcomes in Patients with Non-Penetrant Long QT Syndrome. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317941 Summary: T. Syndrome. Non-penetrant Long Q. T. Syndrome, defined as the absence of objective electrocardiographic or cardiac evidence of abn

Welcome to Cardiology Today – Recorded November 30, 2025. This episode summarizes 5 key cardiology studies on topics like digital biomarker and wild-type amyloid. Key takeaway: HRV-CV: A Digital Biomarker for Age, Sex, and Behavior. Article Links: Article 1: Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. (European journal of heart failure) Article 2: Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. (European journal of heart failure) Article 3: Left atrioventricular ratio (LA:LV): Using left ventricular size as the reference for identifying maladaptive left atrial remodelling. (European heart journal. Cardiovascular Imaging) Article 4: Heart Rate Variability Coefficient of Variation During Sleep as a Digital Biomarker That Reflects Behavior and Varies by Age and Sex. (American journal of physiology. Heart and circulatory physiology) Article 5: Mid- and Late-term Left Ventricular Diastolic Function After the Ross Procedure. (Pediatric cardiology) Full episode page: https://podcast.explainheart.com/podcast/hrv-cv-a-digital-biomarker-for-age-sex-and-behavior-11-30-25/ Featured Articles Article 1: Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317156 Summary: Tafamidis has significantly advanced the treatment paradigm for transthyretin amyloid cardiomyopathy, as demonstrated by results from a phase three randomized controlled trial. However, comprehensive real-world data detailing its use remain limited. A critical need exists to understand the clinical phenotype of patients receiving tafamidis for wild-type transthyretin amyloid cardiomyopathy and its association with survival outside of controlled trial settings. This gap highlights the importance of observational data for characterizing outcomes in diverse patient populations. Article 2: Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317156 Summary: Tafamidis has significantly advanced the treatment paradigm for transthyretin amyloid cardiomyopathy, as demonstrated by results from a phase three randomized controlled trial. However, comprehensive real-world data detailing its use remain limited. A critical need exists to understand the clinical phenotype of patients receiving tafamidis for wild-type transthyretin amyloid cardiomyopathy and its association with survival outside of controlled trial settings. This gap highlights the importance of observational data for characterizing outcomes in diverse patient populations. Article 3: Left atrioventricular ratio (LA:LV): Using left ventricular size as the reference for identifying maladaptive left atrial remodelling. Journal: European heart journal. Cardiovascular Imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41299774 Summary: The left atrioventricular ratio, defined as the ratio of maximal Left Atrial End-Systolic Volume to Left Ventricular End-Diastolic Volume, provides valuable context for cardiac remodeling assessment. This echocardiography-based measure aids in distinguishing between physiological and pathological cardiac changes. It addresses the critical need to consider the interdependence of left atrial and left ventricular remodeling, a relationship often overlooked in standard clinical practice. Article 4: Heart Rate Variability Coefficient of Variation During Sleep as a Digital Biomarker That Reflects Behavior and Varies by Age and Sex. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41309064 Summary: The heart rate variability coefficient of variation, an index of day-to-day cardiac autonomic fluctuation, functions as a scalable digital biomarker. This biomarker reliably reflects behavior and exhibits variations according to both age and sex. It offers significant potential for behavioral monitoring and health risk stratification in diverse populations. Article 5: Mid- and Late-term Left Ventricular Diastolic Function After the Ross Procedure. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41313350 Summary: Long-term ventricular mechanics following the Ross procedure for congenital aortic valve disease are not well understood. This procedure, a common surgical option, requires further investigation into its mid- and late-term effects on left ventricular diastolic function. Understanding these long-term functional characteristics is crucial, particularly when comparing outcomes to other surgical repairs for congenital heart lesions. Transcript Today’s date is November 30, 2025. Welc

Welcome to Cardiology Today – Recorded November 29, 2025. This episode summarizes 5 key cardiology studies on topics like Left Ventricular Ejection Fraction and British Columbia. Key takeaway: Pediatric Kidney Transplant: 69% Rehospitalized within Year.. Article Links: Article 1: Association of rehospitalization after pediatric kidney transplantation with kidney function at 1-year post-transplant and long-term allograft failure. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Noninvasive Assessment of Right Ventricular-Pulmonary Arterial Coupling in Repaired Tetralogy of Fallot by Magnetic Resonance Imaging. (Journal of the American Heart Association) Article 3: Left Ventricular Ejection Fraction Response After Atrial Fibrillation Ablation: Clinical Predictors and Development of the PACED Score. (Heart rhythm) Article 4: Road exposure after cardioverter-defibrillator implantation and its potential influence on reported motor vehicle crash risks. (The American journal of cardiology) Article 5: Association of Body Mass Index with ten-year outcomes in asymptomatic stage a/B heart failure patients: Insights from the CHART-2 study. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/pediatric-kidney-transplant-69-rehospitalized-within-year-11-29-25/ Featured Articles Article 1: Association of rehospitalization after pediatric kidney transplantation with kidney function at 1-year post-transplant and long-term allograft failure. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41314615 Summary: This study found that 29 percent of incident pediatric kidney transplant recipients experienced rehospitalization within the first 30 days post-transplant. Furthermore, over two-thirds of children, specifically 69 percent, were rehospitalized within the first year following their transplant procedure. These findings highlight a high burden of early rehospitalizations in pediatric kidney transplant patients, underscoring the need for improved post-transplant care strategies. Article 2: Noninvasive Assessment of Right Ventricular-Pulmonary Arterial Coupling in Repaired Tetralogy of Fallot by Magnetic Resonance Imaging. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294083 Summary: This study evaluated a noninvasive, volume-based parameter for Right Ventricular-Pulmonary Arterial coupling in a cohort of 92 pediatric and 105 adult patients with repaired Tetralogy of Fallot. Right Ventricular-Pulmonary Arterial coupling quantifies right ventricular contractility in relation to its afterload, a crucial measure traditionally requiring high-fidelity catheter-derived pressure-volume loops. The investigation explored this noninvasive parameter’s utility in assessing ventricular function in this patient population, addressing the need for less invasive evaluation methods compared to traditional approaches. Article 3: Left Ventricular Ejection Fraction Response After Atrial Fibrillation Ablation: Clinical Predictors and Development of the PACED Score. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41314586 Summary: This multicenter cohort study identified pre-procedural predictors of Left Ventricular Ejection Fraction response following atrial fibrillation ablation in patients with Left Ventricular Systolic Dysfunction. The study included patients with atrial fibrillation and a Left Ventricular Ejection Fraction less than 50 percent who underwent an index ablation procedure. The study developed the P. A. C. E. D. Score to pragmatically stratify patients for Left Ventricular Ejection Fraction response after ablation. Catheter ablation for atrial fibrillation improves outcomes in patients with Left Ventricular Systolic Dysfunction, making prediction of Left Ventricular Ejection Fraction response clinically valuable. Article 4: Road exposure after cardioverter-defibrillator implantation and its potential influence on reported motor vehicle crash risks. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41314365 Summary: This study obtained 18 years of population-based health and driving data from British Columbia, Canada, for drivers who underwent implantable cardioverter-defibrillator implantation. Researchers estimated drivers’ monthly road exposure relative to baseline to understand its influence on motor vehicle crash risk interpretation. This investigation highlights how transient reductions in driving after implantable cardioverter-defibrillator implantation can significantly affect the reported crash risk, necessitating careful consideration in risk assessment. Article 5: Association of Body Mass Index with ten

Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like cardiovascular disease and aspirin dosing. Key takeaway: Epigenetic Aging Predicts Cardiovascular Disease. Article Links: Article 1: Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study. (Journal of the American Heart Association) Article 2: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. (Journal of the American Heart Association) Article 3: Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE. (Journal of the American Heart Association) Article 4: Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States. (Journal of the American Heart Association) Article 5: Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/epigenetic-aging-predicts-cardiovascular-disease-11-28-25/ Featured Articles Article 1: Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294102 Summary: The study compared clinical profiles and biventricular remodeling in patients with pulmonary hypertension residing at high altitudes (2500 meters or greater) versus low altitudes. It revealed distinct patterns of cardiac adaptation and disease progression influenced by hypobaric hypoxia. Understanding these specific altitude-related differences is crucial for developing tailored management strategies. This research provides a foundation for improving outcomes for pulmonary hypertension patients in diverse geographical environments. Article 2: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294095 Summary: N. A. Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. This prospective cohort study systematically compared 13 D. N. A. methylation algorithms to assess their relation to incident cardiovascular disease risk in 2112 older adults over a 6-year follow-up. The research clarified the differential utility of various D. N. A. methylation-based aging algorithms in predicting cardiovascular disease. This comparison provides important insights into the most effective epigenetic biomarkers for risk stratification. These findings support the integration of advanced aging algorithms into cardiovascular disease prediction models for older adults. Article 3: Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294093 Summary: The ADAPTABLE trial provided specific evidence on the effectiveness and safety of two different aspirin doses for secondary prevention of atherosclerotic cardiovascular disease in patients with chronic obstructive pulmonary disease or asthma. This research demonstrates how optimal antiplatelet therapy differs for individuals with co-existing respiratory conditions, who carry increased cardiovascular risk. The findings inform tailored clinical decisions on aspirin dosing for secondary prevention. This study contributes to refining guideline recommendations for complex cardiovascular patient profiles. Article 4: Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294090 Summary: This study investigated the association between caregiver intergenerational socioeconomic mobility and cardiovascular health in both Hispanic/Latino youth and their caregivers. The research identified specific patterns in how socioeconomic background across generations influences cardiovascular health outcomes in this population. It further determined whether these associations are modified by youth’s sex and age, providing detailed insights into risk factors. Understanding these intergenerational and socioeconomic determinants is crucial for developing targeted public health interventions to improve cardiovascular health in Hispanic/Latino communities. Article 5: Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes. Journal: Journal of the American He

Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like high-sensitivity troponin T and atherosclerotic cardiovascular disease. Key takeaway: Cardiac Amyloidosis Survival Up Over Time.. Article Links: Article 1: A polygenic risk score for peripheral artery disease and major adverse limb events. (European heart journal) Article 2: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways. (Journal of the American Heart Association) Article 3: Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy. (Journal of the American Heart Association) Article 4: Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study. (Journal of the American Heart Association) Article 5: Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/cardiac-amyloidosis-survival-up-over-time-11-28-25/ Featured Articles Article 1: A polygenic risk score for peripheral artery disease and major adverse limb events. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41312852 Summary: Large-scale genome-wide association studies identified common genetic variants that predict peripheral artery disease risk. This study assessed a specific polygenic risk score for its association with peripheral artery disease and major adverse limb events, independent of other clinical risk factors. The research involved a genetic analysis using individual patient data pooled from six Thrombolysis in Myocardial Infarction trials. This approach demonstrates the method for integrating genetic predisposition into risk stratification for limb-related cardiovascular outcomes. Article 2: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294135 Summary: Small RNA sequencing of human urinary extracellular vesicles revealed an association between a high-sodium diet and renal proinflammatory pathways. This study demonstrated that high sodium intake is linked to mechanisms beyond hemodynamic changes, including endothelial dysfunction and oxidative stress. Researchers observed the induction of a proinflammatory milieu in the kidneys. The findings highlight how dietary sodium modulation impacts renal pathophysiology at a molecular level in normotensive subjects. Article 3: Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294120 Summary: This study established the diagnostic and prognostic value of high-sensitivity troponin T for cardiovascular outcomes in patients receiving immune-checkpoint inhibitor therapy. Immune-checkpoint inhibitors are known to be associated with adverse cardiac events, with troponin elevation already a diagnostic criterion for immune-checkpoint inhibitor-related myocarditis and myocardial infarction. The research documented additional causes of troponin elevation and their observed outcomes, including cardiac death and heart failure, in these patients. This comprehensive analysis clarified the clinical utility of high-sensitivity troponin T measurements across a broad spectrum of cardiac issues in this specific patient group. Article 4: Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294118 Summary: This Veterans Health Administration study found a significant association between monoclonal gammopathy of undetermined significance and incident cardiovascular disease risk. Monoclonal gammopathy of undetermined significance was already known to be associated with an increased cardiovascular disease risk. The research demonstrated that monoclonal gammopathy of undetermined significance status provided additional prognostic information beyond traditional atherosclerotic cardiovascular disease risk calculation. This finding highlights the crucial role of considering monoclonal gammopathy of undetermined significance in comprehensive cardiovascular risk assessment. Article 5: Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294107 Summar

Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like Atherosclerosis and Proinflammatory cytokines. Key takeaway: Aspirin Elimination Safe for HeartMate 3 LVADs. Article Links: Article 1: Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial. (Journal of cardiac failure) Article 2: Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer. (Journal of the American Heart Association) Article 3: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. (Journal of the American Heart Association) Article 4: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa. (Journal of the American Heart Association) Article 5: Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/aspirin-elimination-safe-for-heartmate-3-lvads-11-28-25/ Featured Articles Article 1: Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41308860 Summary: The ARIES-HM3 trial confirmed the safety and effectiveness of aspirin elimination from the antithrombotic regimen following HeartMate 3 Left Ventricular Assist Device implantation. This specific analysis determined the interaction of atrial fibrillation, diabetes mellitus, and obesity with aspirin elimination regarding hemocompatibility-related adverse events at one year post-implant. The trial randomized patients with a HeartMate 3 Left Ventricular Assist Device to receive aspirin or placebo. This investigation informs personalized antithrombotic management for patients with these common comorbidities. Article 2: Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294143 Summary: Immune checkpoint inhibitors are associated with a three-fold risk of atherosclerotic cardiovascular disease. This single-center retrospective study demonstrated factors associated with atherosclerotic cardiovascular disease in women following immune checkpoint inhibitor therapy. The investigation also characterized plaque progression specifically among women with cancer receiving these treatments. Article 3: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294142 Summary: The loss of endothelial Yes Associated Protein 1 and WW Domain Containing Transcription Regulator 1 reduced the size of chronic stroke lesions and altered the endothelial environment. This study revealed that brain endothelial cells play a critical role in determining stroke outcomes. The findings indicate a potential therapeutic target for ischemic stroke, a leading cause of morbidity and mortality. Article 4: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294140 Summary: Plasma from patients with severe aortic stenosis had a detrimental effect on valvular endothelial cells. This effect included inducing oxidative stress and contributing to valvular endothelial cell dysfunction. Proinflammatory cytokines, such as interleukin and tumor necrosis factor alpha, along with Factor Xa, were found to mediate these harmful processes. The study identified key plasma components contributing to aortic stenosis progression. Article 5: Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294139 Summary: Intracellular osteopontin within macrophages promotes carotid plaque formation by inducing foam cell formation and releasing proinflammatory cytokines. Single cell R. N. A. sequencing of human carotid plaques identified major cell types and a key cell cluster involved in plaque development. In vitro experiments further confirmed the role of osteopontin in macrophages in this process. Transcript Today’s date is November 28, 2025. Welcome to Cardio

Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like abdominal aortic aneurysm and diabetic cardiomyopathy. Key takeaway: Cell-Free DNA Predicts LVAD Outcomes. Article Links: Article 1: Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. (European heart journal) Article 2: Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation. (Circulation. Heart failure) Article 3: Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People. (Journal of the American Heart Association) Article 4: Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension. (Journal of the American Heart Association) Article 5: C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/cell-free-dna-predicts-lvad-outcomes-11-28-25/ Featured Articles Article 1: Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41307910 Summary: This study demonstrated that neutrophil extracellular traps (NETs) and peptidylarginine deiminase 4 (PAD4)-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Endomyocardial biopsies from heart failure patients showed the presence of NETs, indicating their role in human disease pathology. Research involving wild-type and PAD4-deficient mice further elucidated this connection in diabetic cardiomyopathy and kidney disease. This establishes a critical mechanistic link between diabetes and its severe cardiovascular and renal complications. Article 2: Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41307146 Summary: This study demonstrated that plasma cell-free DNA (cfDNA) accurately profiles end-organ injury and predicts outcomes in patients with advanced heart failure receiving left ventricular assist device (LVAD) implantation. The research identified cfDNA as a valuable biomarker for risk stratification following LVAD placement. It analyzed a multicenter prospective cohort of heart failure patients, including those with and without LVADs, to establish this predictive capability. This finding offers a novel approach to assess adverse events and improve risk management in this patient population. Article 3: Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294148 Summary: This study found that immune cell type-specific DNA methylation regions associate with 24-hour blood pressure regulation in Black people. Researchers established this connection by employing advanced deconvolution algorithms to analyze reduced representation bisulfite sequencing data. The study identified specific epigenetic markers within immune cells that play a role in blood pressure control. These findings highlight a novel mechanism linking immune cell epigenetics to hypertension risk within this specific population. Article 4: Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294147 Summary: This study revealed stage-dependent vascular and neural transcriptomic pathways leading to inflammation and cognitive dysfunction in a rat model of hypertension. Researchers identified specific molecular and cellular mechanisms occurring at different stages of hypertension progression. The findings indicate distinct inflammatory and neural changes contributing to cerebral microvascular dysfunction and increased dementia risk. This research provides crucial insights into the complex pathogenesis of hypertension-related cognitive decline. Article 5: C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294146 Summary: This study found that C-C chemokine receptor 4 (CCR4) deficiency protects against abdominal aortic aneurysm (AAA) formation. Researchers observed this protective effect in hypercholesterolemic CCR4-deficient mice. The findings suggest that CCR4, predominantly expressed on T cells

Welcome to Cardiology Today – Recorded November 27, 2025. This episode summarizes 5 key cardiology studies on topics like Gene expression profiling and Graft survival. Key takeaway: New Tests Predict Heart Transplant Risk. Article Links: Article 1: Trends in Prevalence, Treatment, and Control of Cardiometabolic Risk Factors Among Adults With Hypertension in the United States, 1999-2023. (Journal of the American College of Cardiology) Article 2: Multimodal Molecular Testing Provides Prognostic Value for Heart Transplant Recipients. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Results of the MACiTEPH study of macitentan for the treatment of inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Enhancement of suppressive function of Ly49+ CD8+ T cells in allogeneic immunity by CD80/86-CD28 blockade in mouse. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Fifty-Year Pediatric Heart Transplant Outcomes: A Pediatric-Adult Center Linked Analysis. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/new-tests-predict-heart-transplant-risk-11-27-25/ Featured Articles Article 1: Trends in Prevalence, Treatment, and Control of Cardiometabolic Risk Factors Among Adults With Hypertension in the United States, 1999-2023. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41295934 Summary: The United States observed a sharp increase in hypertension-related deaths over the past decade, underscoring the need for public health strategies. This study identified 21822 adults with hypertension from 1999 to 2023 through the National Health and Nutrition Examination Survey. Researchers collected data on changes in age-adjusted prevalence of diabetes and other cardiometabolic risk factors within this population. The analysis of these trends offers critical insights into the evolving landscape of hypertension management. Article 2: Multimodal Molecular Testing Provides Prognostic Value for Heart Transplant Recipients. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41297735 Summary: Multimodal molecular testing with gene expression profiling and donor-derived cell-free deoxyribonucleic acid demonstrated prognostic value for heart transplant recipients. This study evaluated 1934 patients from the Surveillance HeartCare Outcomes Registry. Researchers assessed risk based on the most abnormal test results between two and six months post-transplant. The evaluation provided insights into the joint ability of these molecular tests to predict future clinical events, such as graft dysfunction. Article 3: Results of the MACiTEPH study of macitentan for the treatment of inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41297734 Summary: The MACiTEPH study evaluated macitentan 75 milligrams once daily for treating inoperable or persistent or recurrent chronic thromboembolic pulmonary hypertension. This prospective, double-blind, placebo-controlled, phase three study randomized adult patients one to one to macitentan or placebo. The patient population included individuals with chronic thromboembolic pulmonary hypertension, with or without balloon pulmonary angioplasty, or after pulmonary endarterectomy. The primary endpoint for this investigation was a clinical composite. Article 4: Enhancement of suppressive function of Ly49+ CD8+ T cells in allogeneic immunity by CD80/86-CD28 blockade in mouse. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41297733 Summary: Ly49 positive C D 8 positive T cells restricted by Qa-1 or major histocompatibility complex peptide function as immune suppressors in allogeneic immunity. In organ transplantation, a C-X-C motif chemokine receptor 5 positive Ly49 positive C D 8 positive T cell subset suppresses C D 4 positive T cell activation through Qa-1 recognition. This action inhibits donor-specific antibody production and promotes heart graft survival. This suppressive effect is particularly enhanced under C D 80/86-C D 28 co-blockade. Article 5: Fifty-Year Pediatric Heart Transplant Outcomes: A Pediatric-Ad

Welcome to Cardiology Today – Recorded November 26, 2025. This episode summarizes 5 key cardiology studies on topics like cardiac arrhythmias and incretin therapies. Key takeaway: Semaglutide Efficacy in H. F. pEF Across Age. Article Links: Article 1: Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme. (European journal of heart failure) Article 2: Predictive factors for permanent pacemaker implantation and mortality after transcatheter aortic valve replacement in patients with pre-existing atrial fibrillation. (Cardiology) Article 3: Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme. (European journal of heart failure) Article 4: Echocardiographic right-ventricular global wasted work predicts haemodynamics and risk profile in pulmonary arterial hypertension. (European heart journal. Cardiovascular Imaging) Article 5: Value of cardiovascular magnetic resonance-derived quantitative myocardial blood flow assessment in the setting of chronic coronary occlusion. (European heart journal. Cardiovascular Imaging) Full episode page: https://podcast.explainheart.com/podcast/semaglutide-efficacy-in-h-f-pef-across-age-11-26-25/ Featured Articles Article 1: Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41290376 Summary: Semaglutide demonstrated efficacy in treating obesity-related Heart Failure with Preserved Ejection Fraction in the overall S. T. E. P. minus H. F. pEF trials. This pre-specified pooled subanalysis of the S. T. E. P. minus H. F. pEF program evaluated semaglutide’s effects across the age spectrum. The analysis provided important data addressing prior speculation that older patients might benefit less from incretin therapies, contributing to understanding its therapeutic application in diverse age groups. Article 2: Predictive factors for permanent pacemaker implantation and mortality after transcatheter aortic valve replacement in patients with pre-existing atrial fibrillation. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41289183 Summary: Atrial fibrillation is the most common arrhythmia observed in patients undergoing transcatheter aortic valve replacement. This study provided specific data to identify predictors for permanent pacemaker implantation in patients with pre-existing atrial fibrillation. It also investigated the association between permanent pacemaker implantation and long-term mortality in this patient group, addressing a critical knowledge gap in transcatheter aortic valve replacement outcomes. Article 3: Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41290376 Summary: Semaglutide demonstrated efficacy in treating obesity-related Heart Failure with Preserved Ejection Fraction in the overall S. T. E. P. minus H. F. pEF trials. This pre-specified pooled subanalysis of the S. T. E. P. minus H. F. pEF program evaluated semaglutide’s effects across the age spectrum. The analysis provided important data addressing prior speculation that older patients might benefit less from incretin therapies, contributing to understanding its therapeutic application in diverse age groups. Article 4: Echocardiographic right-ventricular global wasted work predicts haemodynamics and risk profile in pulmonary arterial hypertension. Journal: European heart journal. Cardiovascular Imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972539 Summary: Novel echocardiographic indices of right ventricular myocardial work are valuable for evaluating pulmonary arterial hypertension. This study demonstrated that these right ventricular myocardial work indices predict haemodynamics and risk profile in patients with pulmonary arterial hypertension. The indices specifically identified patients at high risk for mortality and those with a worse haemodynamic profile, as confirmed by right heart catheterization. Article 5: Value of cardiovascular magnetic resonance-derived quantitative myocardial blood flow assessment in the setting of chronic coronary occlusion. Journal: European heart journal. Cardiovascular Imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40916342 Summary: Visual assessment has traditionally been the primary method for detecting obstructive coronary artery disease using stress perfusion cardiovascular magnetic resonance. This study investigated the diagnostic performance of fully automated quantitative myocardial blood flow assessment in patients with coronary chronic total occlusion. The

Welcome to Cardiology Today – Recorded November 26, 2025. This episode summarizes 5 key cardiology studies on topics like cardiotoxicity and bicuspid aortic stenosis. Key takeaway: Heart Failure Drug Access Disparities Identified.. Article Links: Article 1: Incident cardiovascular events in women with left-sided versus right-sided breast cancer: a propensity score-matched study. (Heart (British Cardiac Society)) Article 2: Surveillance of left ventricular function among cancer survivors. (Heart (British Cardiac Society)) Article 3: Amphilimus-eluting versus zotarolimus-eluting stents in patients with diabetes mellitus and coronary artery disease: extended follow-up of the SUGAR randomised controlled trial. (Heart (British Cardiac Society)) Article 4: Outcomes of transcatheter aortic valve replacement in bicuspid versus tricuspid aortic stenosis with severe calcification. (Heart (British Cardiac Society)) Article 5: Disparities in prescriptions among Danish heart failure patients: a national longitudinal cohort study. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/heart-failure-drug-access-disparities-identified-11-26-25/ Featured Articles Article 1: Incident cardiovascular events in women with left-sided versus right-sided breast cancer: a propensity score-matched study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40829861 Summary: Cardiotoxic effects of breast cancer therapies, including drugs and radiotherapy, are known to increase cardiovascular morbidity, particularly atrial fibrillation. This study precisely evaluated laterality-specific cardiovascular risks in women with left-sided versus right-sided breast cancer. Utilizing global healthcare data from the TriNetX network, the research clarified the specific impact of breast cancer laterality on incident cardiovascular events. Article 2: Surveillance of left ventricular function among cancer survivors. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40763997 Summary: Cancer survivors demonstrate an increased risk of heart failure, which is balanced by the risk of death from other causes, influencing optimal cardiac surveillance timing. This cross-sectional study investigated the association between cancer history and cardiac function across various follow-up periods. The research provided crucial data for determining effective guideline-recommended surveillance strategies for left ventricular function in this patient population. Article 3: Amphilimus-eluting versus zotarolimus-eluting stents in patients with diabetes mellitus and coronary artery disease: extended follow-up of the SUGAR randomised controlled trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40562528 Summary: Patients with diabetes mellitus receiving percutaneous coronary intervention experience an elevated risk of late adverse events. The Second-generation Drug-eluting Stents in Diabetes (SUGAR) randomized controlled trial compared amphilimus-eluting stents and onyx-zotarolimus-eluting stents in this high-risk population. The study reported the co-primary endpoint of target lesion failure at two years and extended follow-up at three years. This research provided critical comparative data on stent performance and long-term outcomes for diabetic patients. Article 4: Outcomes of transcatheter aortic valve replacement in bicuspid versus tricuspid aortic stenosis with severe calcification. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348412 Summary: The comparative outcomes of transcatheter aortic valve replacement in bicuspid versus tricuspid aortic stenosis with severe calcification remained unclear. This study rigorously compared the safety and efficacy of transcatheter aortic valve replacement in these patient groups. Researchers analyzed 870 propensity score matched pairs of patients with severe calcification exceeding 470 cubic millimeters. The research clarified specific outcomes to guide optimal treatment strategies for aortic stenosis. Article 5: Disparities in prescriptions among Danish heart failure patients: a national longitudinal cohort study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348409 Summary: Angiotensin receptor-neprilysin inhibitors and sodium-glucose co-transporter two inhibitors hold a Class one indication for acute and chronic heart failure due to benefits in symptom management, rehospitalization, and mortality. This national longitudinal cohort study investigated demographic, geographic, and socioeconomic disparities in the prescription of these essential medications for heart failure patients. The research identified patterns of unequal access to guideline-recommended heart failure therapies among Danish patients, highlighting areas for intervention. Transcript Today’s date is November 26, 2025. Welcom

Welcome to Cardiology Today – Recorded November 25, 2025. This episode summarizes 5 key cardiology studies on topics like adverse outcomes and cardiovascular risk. Key takeaway: Underweight Risk in Type 2 Diabetes. Article Links: Article 1: Cardiac fibroblasts in myocardial injury and heart failure. (European heart journal) Article 2: Frailty and long-term outcomes in younger patients with acute myocardial infarction. (European heart journal) Article 3: Women with chronic coronary artery disease: long-term outcomes after percutaneous coronary intervention vs coronary artery bypass grafting. (European heart journal) Article 4: Underweight and cardiovascular risk in Type 2 diabetes: a Korean nationwide study. (European heart journal) Article 5: Disturbed flow induces reprogramming of endothelial cells to immune-like and foam cells under hypercholesterolaemia during atherogenesis. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/underweight-risk-in-type-2-diabetes-11-25-25/ Featured Articles Article 1: Cardiac fibroblasts in myocardial injury and heart failure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41288379 Summary: Cardiac fibrosis is a major contributor to the development and progression of heart failure. This process involves an aberrant deposition of extracellular matrix components, which leads to impaired mechanical and electrical function of the heart. Fibroblasts are central to these pathological processes. Effective anti-fibrotic treatments currently remain elusive due to limited insights into the molecular and cellular mechanisms distinguishing transient from sustained fibrotic responses. Article 2: Frailty and long-term outcomes in younger patients with acute myocardial infarction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41288370 Summary: Frailty is increasingly recognized as an important determinant of adverse outcomes in older adults with acute myocardial infarction. The impact of frailty on younger patients with acute myocardial infarction remains an underexplored area. This population-based epidemiological study utilized linked national administrative data from England and Wales to investigate this association. Patients in the study were stratified into three age groups: under 55 years, 55 to 74 years, and 75 years or older. Article 3: Women with chronic coronary artery disease: long-term outcomes after percutaneous coronary intervention vs coronary artery bypass grafting. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41288359 Summary: Real-world evidence comparing percutaneous coronary intervention to coronary artery bypass grafting in women with chronic severe coronary artery disease is limited. This propensity score-matched retrospective cohort study linked clinical and administrative databases in Ontario, Canada. The study identified women undergoing either percutaneous coronary intervention or coronary artery bypass grafting from 2012 to 2021. This research addresses a critical evidence gap regarding long-term outcomes for revascularization strategies in this specific patient population. Article 4: Underweight and cardiovascular risk in Type 2 diabetes: a Korean nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41288350 Summary: The growing prevalence of lean Type 2 diabetes mellitus and limited research on stratified underweight categories characterize the current understanding. This nationwide cohort study investigated the association between underweight status and cardiovascular disease risk in patients with Type 2 diabetes mellitus. The study analyzed data from 2064406 adults with Type 2 diabetes mellitus who underwent health examinations between 2015 and 2016 from the Korean National Health Insurance Service database. This research focused on the impact of underweight severity on cardiovascular outcomes within this large patient population. Article 5: Disturbed flow induces reprogramming of endothelial cells to immune-like and foam cells under hypercholesterolaemia during atherogenesis. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41288601 Summary: Atherosclerosis occurs preferentially in arteries exposed to disturbed flow, while stable flow regions are protected even under hypercholesterolaemic conditions. Prior research showed that disturbed flow alone initiates flow-induced reprogramming of endothelial cells, including partial endothelial-to-immune-cell-like transition. These findings, however, lacked validation using a genetic lineage-tracing model. This research highlights the critical role of disturbed flow in endothelial cell changes during atherogenesis under hypercholesterolaemia. Transcript Today’s date is November 25, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Cardiac fibroblasts in myocardial injury a

Welcome to Cardiology Today – Recorded November 25, 2025. This episode summarizes 5 key cardiology studies on topics like medication intensification and cognitive impairment. Key takeaway: Extensive Cardiac Lymphatic Network Defined. Article Links: Article 1: Importance of Adherence Versus Intensification in Attaining Blood Pressure Control. (Hypertension (Dallas, Tex. : 1979)) Article 2: Incidence and Mortality of Chronic Subdural Hematomas: A Population-Based Study. (Stroke) Article 3: Towards an Understanding of Best Practice – The Good, The Bad and the Future of Cardiogenic Shock Teams. (American heart journal) Article 4: Normal cardiac lymphatics and their mimics. (American journal of physiology. Heart and circulatory physiology) Article 5: Chronic Kidney Disease and Cardiac Remodeling Potentiate Cognitive Impairment Progression: Disentangling the Sex-Specific Crosstalk of Kidney-Heart-Brain Axis. (American journal of physiology. Heart and circulatory physiology) Full episode page: https://podcast.explainheart.com/podcast/extensive-cardiac-lymphatic-network-defined-11-25-25/ Featured Articles Article 1: Importance of Adherence Versus Intensification in Attaining Blood Pressure Control. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41287963 Summary: Optimizing blood pressure control requires a clear understanding of the distinct roles of medication adherence and antihypertensive intensification, insights critical for clinical care and quality improvement initiatives. This study defined primary care patients with hypertension experiencing uncontrolled blood pressure readings. It established a method to classify patients as having high (80 percent or greater) or low (less than 80 percent) adherence based on six months of prescription fill data. Such classification provides an essential framework for future investigations into improving blood pressure outcomes. Article 2: Incidence and Mortality of Chronic Subdural Hematomas: A Population-Based Study. Journal: Stroke PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41287962 Summary: Chronic subdural hematomas (cSDH) represent a growing public health burden, yet specific, population-based data on their incidence and mortality in the United States have been limited. This study delivered the first estimates of chronic subdural hematoma incidence and mortality within a large, representative U.S. population. Researchers identified and adjudicated all adult cases of chronic subdural hematoma in 2019 and 2020 across a five-county region of Southern Ohio and Northern Kentucky. These findings provide foundational epidemiological data essential for public health planning and clinical resource allocation related to chronic subdural hematomas. Article 3: Towards an Understanding of Best Practice – The Good, The Bad and the Future of Cardiogenic Shock Teams. Journal: American heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41285212 Summary: Cardiogenic shock remains a condition with persistently high mortality, underscoring the critical need for rapid diagnosis, coordinated multidisciplinary management, and timely mechanical circulatory support. The study observed significant variability in the structure, activation, and sustainability of dedicated cardiogenic shock teams across institutions. In response, the Society of Critical Care Cardiology, in partnership with other organizations, characterized this heterogeneity to advance understanding towards defining optimal components for these teams. This work establishes the importance of standardizing cardiogenic shock team practices to improve patient outcomes. Article 4: Normal cardiac lymphatics and their mimics. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41285409 Summary: Preclinical models of cardiovascular disease demonstrate significant lymphatic structural remodeling and dysfunction, yet the detailed normal structure and distribution of lymphatic vessels in the heart remained largely undefined. This study successfully defined the pattern of lymphatic vessels at various cardiac anatomical sites using Prox1-tdTomato lymphatic reporter mice. Through light sheet microscopy, researchers confirmed the presence of an extensive network of lymphatic vessels directly on the epicardium. These findings provide foundational anatomical insights into the cardiac lymphatic system, crucial for understanding its role in both health and disease. Article 5: Chronic Kidney Disease and Cardiac Remodeling Potentiate Cognitive Impairment Progression: Disentangling the Sex-Specific Crosstalk of Kidney-Heart-Brain Axis. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41285406 Summary: Chronic kidney disease and cardiac remodeling are significant potentiators of cognitive impairment progression through oxidative stress, uremic toxicity,

Welcome to Cardiology Today – Recorded November 25, 2025. This episode summarizes 5 key cardiology studies on topics like clonal hematopoiesis and risk communication. Key takeaway: Colchicine Influences Clonal Hematopoiesis Dynamics. Article Links: Article 1: Remnant Cholesterol as an Independent Cardiovascular Risk Factor in Young Adults: An Age-Stratified Cohort Study. (Journal of the American College of Cardiology) Article 2: Age and Sex-Specific Percentiles of 30-Year Cardiovascular Disease Risk Based on the PREVENT Equations. (Journal of the American College of Cardiology) Article 3: Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis. (Journal of the American College of Cardiology) Article 4: Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial. (Journal of the American College of Cardiology) Article 5: Noninvasive Assessment of Mean Pulmonary Artery Pressure: a Comparison of Doppler Echocardiographic Methods. (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography) Full episode page: https://podcast.explainheart.com/podcast/colchicine-influences-clonal-hematopoiesis-dynamics-11-25-25/ Featured Articles Article 1: Remnant Cholesterol as an Independent Cardiovascular Risk Factor in Young Adults: An Age-Stratified Cohort Study. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41260759 Summary: This study involving 4308405 participants found that remnant cholesterol is an independent cardiovascular risk factor. It significantly contributes to the residual risk of cardiovascular disease beyond low-density lipoprotein cholesterol across various age groups. The data demonstrated this association with major adverse cardiovascular events, particularly highlighting its relevance even in young adults. This finding underscores the importance of considering remnant cholesterol in cardiovascular risk assessment. Article 2: Age and Sex-Specific Percentiles of 30-Year Cardiovascular Disease Risk Based on the PREVENT Equations. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41260756 Summary: This study developed population-based age and sex-specific percentiles for 30-year cardiovascular disease risk. These percentiles, based on the PREVENT equations, provide a crucial tool for long-term risk assessment in younger adults. The data showed that framing cardiovascular disease risk relative to peers significantly aids in risk communication for both clinicians and patients. This method offers a clear, complementary approach to current absolute risk estimates. Article 3: Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41123524 Summary: This study analyzed longitudinal data and found specific associations between changes in light-to-moderate alcohol consumption and subsequent blood pressure changes. Results showed that alcohol cessation and initiation distinctly influenced blood pressure levels in both women and men. The data provided sex-specific estimates on these effects, further clarifying the impact across different types of alcoholic beverages. This demonstrates a measurable link between modest alcohol intake modifications and cardiovascular health. Article 4: Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40892620 Summary: This exploratory substudy of the LoDoCo2 trial found an association between randomization to colchicine and the longitudinal dynamics of clonal hematopoiesis. The data indicated that colchicine, an anti-inflammatory therapy, influences clonal hematopoiesis, a condition associated with increased cardiovascular event risk. The study demonstrated a link between an anti-inflammatory treatment and the dynamics of these aging-related hematologic clones in humans. This offers novel insights into managing clonal hematopoiesis and its cardiovascular implications. Article 5: Noninvasive Assessment of Mean Pulmonary Artery Pressure: a Comparison of Doppler Echocardiographic Methods. Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41285299 Summary: This study compared several Doppler echocardiographic methods for estimating mean pulmonary artery pressure against right heart catheterization. The data evaluated the yield and agreement of each echocardiographic method in a real-world cohort of 122 patients. Results clarified the performance of noninva

Welcome to Cardiology Today – Recorded November 24, 2025. This episode summarizes 5 key cardiology studies on topics like prevalence and carotid intima-media thickness. Key takeaway: Metabolic Shifts Raise Heart Disease Risk. Article Links: Article 1: HRS/ACC Scientific Statement: Guiding Principles on the Performance of Intracardiac Ablation Procedures in Ambulatory Surgical Centers. (Journal of the American College of Cardiology) Article 2: Risk of Coronary Artery Disease Associated With Transitions in Metabolic Health in a Clinical Cohort of 69 272. (Journal of the American Heart Association) Article 3: Burden of Unfair Treatment and Subclinical Atherosclerotic Risk Among Black Adults: The Moderating Role of Religious Coping. (Journal of the American Heart Association) Article 4: Prevalence, Clinical Correlates, and Prognostic Impact of Tricuspid Regurgitation in Older Adults: The ARIC Study. (Journal of the American Heart Association) Article 5: HRS/ACC scientific statement: Guiding principles on the performance of intracardiac ablation procedures in ambulatory surgical centers. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/metabolic-shifts-raise-heart-disease-risk-11-24-25/ Featured Articles Article 1: HRS/ACC Scientific Statement: Guiding Principles on the Performance of Intracardiac Ablation Procedures in Ambulatory Surgical Centers. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41283865 Summary: Ambulatory Surgical Centers in the United States are established as a cost-effective, patient-centric alternative for intracardiac ablation procedures, supported by Centers for Medicare and Medicaid Services policy expansions. These centers accommodate a range of procedures, leveraging technological and procedural advancements to facilitate same-day discharge protocols. This model effectively delivers care by allowing appropriately selected patients to undergo complex cardiac interventions outside traditional hospital settings. Article 2: Risk of Coronary Artery Disease Associated With Transitions in Metabolic Health in a Clinical Cohort of 69 272. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41283206 Summary: This study identified a quantifiable risk of coronary artery disease associated with transitions in metabolic health within a large clinical cohort of 69272 individuals. Researchers specifically quantified these risks linked to adverse metabolic transitions, analyzing components such as diabetes, hypertension, elevated triglycerides, and low high-density lipoprotein. The findings demonstrated that recent onset metabolic dysfunction directly influences the probability of incident coronary artery disease. Article 3: Burden of Unfair Treatment and Subclinical Atherosclerotic Risk Among Black Adults: The Moderating Role of Religious Coping. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41283203 Summary: This study found that religious coping modified the longitudinal associations between lifetime discrimination and subclinical atherosclerotic cardiovascular disease risk among Black individuals. Researchers observed these effects differed by sex within a cohort of 753 Black adult participants. The data demonstrated that specific religious coping mechanisms influence the impact of unfair treatment on carotid intima-media thickness, a key indicator of cardiovascular health. Article 4: Prevalence, Clinical Correlates, and Prognostic Impact of Tricuspid Regurgitation in Older Adults: The ARIC Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41283192 Summary: This study quantified the prevalence, clinical correlates, and prognostic impact of tricuspid regurgitation in 3046 community-based older adults from the Atherosclerosis Risk in Communities study. Researchers assessed tricuspid regurgitation severity using echocardiography, categorizing it from none or trace to severe. The findings established definitive data on the association of tricuspid regurgitation with older age and a heightened mortality rate within this specific population. Article 5: HRS/ACC scientific statement: Guiding principles on the performance of intracardiac ablation procedures in ambulatory surgical centers. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41283871 Summary: Ambulatory Surgical Centers in the United States are established as a cost-effective, patient-centric alternative for intracardiac ablation procedures, supported by Centers for Medicare and Medicaid Services policy expansions. These centers accommodate a range of procedures, leveraging technological and procedural advancements to facilitate same-day discharge protocols. This model effectively delivers care by allowing appropriately selected patients to undergo complex cardiac interventions outside traditional hospital

Welcome to Cardiology Today – Recorded November 24, 2025. This episode summarizes 4 key cardiology studies on topics like hypertrophic cardiomyopathy and proteomics. Key takeaway: Genetic Sodium Blockade for Arrhythmias. Article Links: Article 1: Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade. (Circulation) Article 2: Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. (Circulation. Heart failure) Article 3: Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. (Circulation. Heart failure) Article 4: Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis. (Lancet (London, England)) Full episode page: https://podcast.explainheart.com/podcast/genetic-sodium-blockade-for-arrhythmias-11-24-25/ Featured Articles Article 1: Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41277422 Summary: This study identified a specific Finnish-enriched SCN5A missense variant (T220I) that acts as a natural lifelong cardiac sodium channel blockade. Researchers found this genetic variant significantly impacts cardiac arrhythmias, associated mortality, and electrocardiogram phenotypes. The observational study encompassed over 1 million individuals across three large cohorts. These findings demonstrate a genetic proxy’s role in influencing cardiac electrical activity and associated clinical outcomes. Article 2: Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41277423 Summary: This research demonstrated that global proteoform alterations across multiple cellular compartments underlie obstructive hypertrophic cardiomyopathy. The study established that contributions beyond the sarcomere are significant to the heterogeneity of hypertrophic cardiomyopathy phenotypes. Top-down proteomics was identified as a powerful method for analyzing proteoforms, revealing their crucial role in disease mechanisms. These findings advanced the understanding of hypertrophic cardiomyopathy beyond traditional sarcomeric views. Article 3: Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41277423 Summary: This research demonstrated that global proteoform alterations across multiple cellular compartments underlie obstructive hypertrophic cardiomyopathy. The study established that contributions beyond the sarcomere are significant to the heterogeneity of hypertrophic cardiomyopathy phenotypes. Top-down proteomics was identified as a powerful method for analyzing proteoforms, revealing their crucial role in disease mechanisms. These findings advanced the understanding of hypertrophic cardiomyopathy beyond traditional sarcomeric views. Article 4: Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis. Journal: Lancet (London, England) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41115437 Summary: This individual-level pooled analysis, FLUNITY-HD, integrated data from two large-scale trials conducted in Denmark and Spain, enhancing generalizability. The study determined the relative vaccine effectiveness of high-dose inactivated influenza vaccine compared to standard-dose inactivated influenza vaccine against severe clinical outcomes in older adults. This comprehensive assessment provided important comparative information on influenza vaccine efficacy for hospitalizations in this vulnerable population. The pooled analysis yielded a robust assessment of vaccine performance in older adults. Transcript Today’s date is November 24, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade. This study identified a specific Finnish-enriched SCN5A missense variant (T220I) that acts as a natural lifelong cardiac sodium channel blockade. Researchers found this genetic variant significantly impacts cardiac arrhythmias, associated mortality, and electrocardiogram phenotypes. The observational study encompassed over 1 million individuals across three large cohorts. These findings demonstrate a genetic proxy’s role in influencing cardiac electrical activity and associated clinical outcomes. Article number two. Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. This research demonstrated that global proteoform altera

Welcome to Cardiology Today – Recorded November 24, 2025. This episode summarizes 5 key cardiology studies on topics like atrial septal defect and dextrocardia. Key takeaway: Novel R.V.O.T. Repair in Tetralogy of Fallot. Article Links: Article 1: An Encouraging Approach to Complex ASDs: A Multicenter Study. (Pediatric cardiology) Article 2: Parallel Transcatheter Valve and Stent Placement with Subsequent Stent Occlusion to Address a Giant Dysfunctional RVOT in a Patient with Repaired Tetralogy of Fallot. (Pediatric cardiology) Article 3: Incidental diagnosis of a complex cyanotic congenital heart defect in a 32-year-old with orbital abscess. (Cardiology in the young) Article 4: Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial. (Lancet (London, England)) Article 5: Global, regional, and national burden of chronic kidney disease in adults, 1990-2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023. (Lancet (London, England)) Full episode page: https://podcast.explainheart.com/podcast/novel-r-v-o-t-repair-in-tetralogy-of-fallot-11-24-25/ Featured Articles Article 1: An Encouraging Approach to Complex ASDs: A Multicenter Study. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41269259 Summary: The study found that transcatheter closure was performed in patients with complex atrial septal defects presenting with challenging conditions such as large defects, rim deficiency, or multifenestrated defects. This multicenter retrospective analysis evaluated the application of transcatheter techniques in cases where surgical repair might traditionally be preferred. The inclusion of patients with low age and weight also demonstrated the broad application of this approach. This indicates an encouraging expansion of percutaneous atrial septal defect closure to more complicated anatomies. Article 2: Parallel Transcatheter Valve and Stent Placement with Subsequent Stent Occlusion to Address a Giant Dysfunctional RVOT in a Patient with Repaired Tetralogy of Fallot. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41269258 Summary: A novel transcatheter approach successfully addressed a giant dysfunctional right ventricular outflow tract in a patient with repaired Tetralogy of Fallot and severe pulmonary insufficiency. This innovative strategy involved the parallel placement of a transcatheter valve and a stent, followed by subsequent stent occlusion. This method offered an alternative to open surgery in a complex anatomical case where conventional pulmonary valve replacement options were challenging. The procedure effectively managed right ventricular dilation and arrhythmia risk associated with the dysfunctional outflow tract. Article 3: Incidental diagnosis of a complex cyanotic congenital heart defect in a 32-year-old with orbital abscess. Journal: Cardiology in the young PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41267525 Summary: A 32-year-old adult male was incidentally diagnosed with a complex cyanotic congenital heart defect, including isolated dextrocardia, Double Inlet Left Ventricle (l-looped), and l-Transposed Great Arteries with subpulmonary stenosis. The patient survived into adulthood without cardiac surgeries or medications despite single ventricle physiology. This prolonged survival was attributed to a “self-banded” pulmonary flow, a protective physiological mechanism that naturally regulated pulmonary blood flow. This case highlights how unique compensatory mechanisms can enable long-term survival in severe congenital heart conditions. Article 4: Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial. Journal: Lancet (London, England) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41218621 Summary: Sodium glucose co-transporter two inhibitors, such as dapagliflozin, reduce albuminuria and the risk of chronic kidney disease progression. Non-steroidal mineralocorticoid receptor antagonists demonstrate similar benefits in patients with type two diabetes and chronic kidney disease. The MIRO-CKD multicenter, randomised, double-blind, active-controlled, phase 2b clinical trial investigated the efficacy and safety of the novel mineralocorticoid receptor antagonist balcinrenone in combination with dapagliflozin. This study explored a combination therapeutic approach building on the established benefits of each drug class for patients with chronic kidney disease and albuminuria. Article 5: Global, regional, and national burden of chronic kidney disease in adults, 1990-2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023. Journal: Lancet (Londo

Welcome to Cardiology Today – Recorded November 24, 2025. This episode summarizes 5 key cardiology studies on topics like lymphoproliferative disorders and antithrombin. Key takeaway: Fetal Factors Link Maternal Obesity to Heart Risk. Article Links: Article 1: Incidence and risk factors for malignancy after heart transplantation- Analysis of the UNOS Registry. (American heart journal) Article 2: Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes. (American journal of physiology. Heart and circulatory physiology) Article 3: Cardiac Magnetic Resonance Imaging in Pediatric Heart Transplant Recipients: Correlation with Cardiopulmonary Exercise Testing. (Pediatric cardiology) Article 4: Coronary Anomalies and Early Surgical Outcomes in Transposition of the Great Arteries and Taussig-Bing Anomaly: Insights from 251 Consecutive Arterial Switch Cases. (Pediatric cardiology) Article 5: Comparison of Heparin-Based Anticoagulation in Patients With and Without High Output Chylothorax: A Pilot Study. (Pediatric cardiology) Full episode page: https://podcast.explainheart.com/podcast/fetal-factors-link-maternal-obesity-to-heart-risk-11-24-25/ Featured Articles Article 1: Incidence and risk factors for malignancy after heart transplantation- Analysis of the UNOS Registry. Journal: American heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41275897 Summary: The study analyzed 50370 heart transplant recipients from the United Network for Organ Sharing Registry. This comprehensive analysis identified the incidence, demographics, and specific risk factors associated with de novo malignancy, lymphoproliferative disorders, and solid-organ malignancy subtypes. The findings provided crucial data for understanding cancer risk after heart transplantation. This information is vital for directing prevention and screening strategies in this patient population. Article 2: Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41269698 Summary: This study demonstrated that human fetal circulating factors derived from pregnancies complicated by maternal obesity upregulate genes linked to pathological hypertrophy in neonatal rat cardiomyocytes. The research thus uncovered a mechanistic link where these specific factors induce cardiac changes. This finding clarifies how maternal obesity contributes to increased offspring cardiovascular risk and fetal cardiac dysfunction. Article 3: Cardiac Magnetic Resonance Imaging in Pediatric Heart Transplant Recipients: Correlation with Cardiopulmonary Exercise Testing. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41273424 Summary: The study characterized the relationship between multiparametric cardiac magnetic resonance imaging and markers of exercise capacity in pediatric heart transplant recipients. Data from patients who underwent cardiac magnetic resonance imaging within one year of cardiopulmonary exercise testing informed how graft assessment by imaging reflects functional capacity. This analysis contributed to understanding the utility of cardiac magnetic resonance imaging for surveillance of rejection and coronary artery vasculopathy. Article 4: Coronary Anomalies and Early Surgical Outcomes in Transposition of the Great Arteries and Taussig-Bing Anomaly: Insights from 251 Consecutive Arterial Switch Cases. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41273423 Summary: This study evaluated the impact of coronary artery anomalies on early surgical outcomes in 251 consecutive arterial switch operations performed for transposition of the great arteries and Taussig-Bing anomaly. The analysis provided a comprehensive assessment of factors influencing mortality and postoperative recovery in these complex pediatric cardiac procedures. The findings clarified the prognostic significance of these anomalies in arterial switch operation patients. Article 5: Comparison of Heparin-Based Anticoagulation in Patients With and Without High Output Chylothorax: A Pilot Study. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41273422 Summary: This pilot study compared heparin-based anticoagulation strategies in infants and children with and without high output chylothorax after cardiac surgery. The research addressed concerns that loss of antithrombin in chylothorax may impair the therapeutic effect of antithrombin-dependent anticoagulants like unfractionated heparin and low molecular weight heparin (enoxaparin). The findings provided initial data on the management of anticoagulation in these challenging pediatric patients. Transcript Today’s date is November 24, 2025. Welcome to Cardi

Welcome to Cardiology Today – Recorded November 24, 2025. This episode summarizes 5 key cardiology studies on topics like high-sensitivity cardiac troponin and conduction system disease. Key takeaway: Hydroxychloroquine Cardiotoxicity: Fatal Conduction Disease. Article Links: Article 1: Association between Listing Hemodynamics and Heart Transplantation Waitlist Outcomes: an Analysis of the Scientific Registry of Transplant Recipients. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Validation of the European Society of Cardiology 0/1-hour algorithm for chest pain triage in Asian emergency departments: a multinational stepped-wedge cluster-randomised trial. (Heart (British Cardiac Society)) Article 3: Progressive Conduction System Disease in Hydroxychloroquine Cardiotoxicity: A Call for Early Vigilance. (The American journal of cardiology) Article 4: Systemic and pulmonary congestion by ultrasound and prognosis in heart failure: A pooled cohort analysis. (International journal of cardiology) Article 5: Acute type A aortic dissection following TAVI. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/hydroxychloroquine-cardiotoxicity-fatal-conduction-disease-11-24-25/ Featured Articles Article 1: Association between Listing Hemodynamics and Heart Transplantation Waitlist Outcomes: an Analysis of the Scientific Registry of Transplant Recipients. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41276097 Summary: This analysis established specific associations between invasive hemodynamic measurements at the time of heart transplantation listing and subsequent waitlist outcomes. The study clarified how various hemodynamic profiles influence a patient’s risk of removal from the waitlist due to death or clinical deterioration. Utilizing data from the Scientific Registry of Transplant Recipients for adult candidates with statuses one through four and six, this research directly informs risk stratification and optimizes management for patients awaiting heart transplantation. These findings highlight the prognostic significance of pre-transplant hemodynamic assessment. Article 2: Validation of the European Society of Cardiology 0/1-hour algorithm for chest pain triage in Asian emergency departments: a multinational stepped-wedge cluster-randomised trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41276292 Summary: This multinational, stepped-wedge cluster-randomized trial established the safety and clinical utility of the European Society of Cardiology 0/1-hour high-sensitivity cardiac troponin algorithm for chest pain triage. The study validated this algorithm across multiple diverse Asian emergency department settings, addressing a critical need for rapid diagnosis and safe patient disposition. Previously showing promising performance in Western cohorts, this research demonstrated the algorithm’s effectiveness in new populations. These findings support implementing a standardized, efficient diagnostic pathway for chest pain patients in Asian emergency departments. Article 3: Progressive Conduction System Disease in Hydroxychloroquine Cardiotoxicity: A Call for Early Vigilance. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41276147 Summary: This report highlighted the underappreciated and lethal phenotype of progressive conduction system disease caused by hydroxychloroquine (H. C. Q.) cardiotoxicity. A 67-year-old female on chronic H. C. Q. developed progressive conduction abnormalities which led to cardiogenic shock and sudden death, despite initial stabilization with isolated atrial pacing. Autopsy findings confirmed extensive sinoatrial and atrioventricular nodal lysosomal toxicity and fibrosis, indicating irreversible cardiac damage. This case underscores the critical need for early vigilance in monitoring for progressive conduction system disease in patients treated with H. C. Q. Article 4: Systemic and pulmonary congestion by ultrasound and prognosis in heart failure: A pooled cohort analysis. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41276189 Summary: This pooled cohort analysis confirmed that increasing congestion, both pulmonary detected by ultrasound and systemic quantified by inferior vena cava diameter, is associated with worse outcomes in patients with heart failure. The study involved five European cohorts of patients with heart failure, providing robust data on prognostic indicators. The primary outcome, a composite of hospitalization for heart failure and all-cause death, demonstrated the significant prognostic value of assessing both forms of congestion. This research provides a robust und

Welcome to Cardiology Today – Recorded November 23, 2025. This episode summarizes 5 key cardiology studies on topics like machine learning and C. T. A.. Key takeaway: AI Boosts C. T. A. Heart Risk Prediction.. Article Links: Article 1: In vitro approaches to mimic cardiac mechanical load dynamics for enhancing maturation and disease modelling. (Cardiovascular research) Article 2: S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts. (Hypertension (Dallas, Tex. : 1979)) Article 3: Nobiletin Prevents Cardiac Hypertrophy via SIRT5-Mediated Downregulation of p300. (Hypertension (Dallas, Tex. : 1979)) Article 4: Primary Aldosteronism: Small Molecule Antagonists of Mutant KCNJ5 Potassium Channels. (Hypertension (Dallas, Tex. : 1979)) Article 5: Machine Learning Model for Atherosclerosis Evaluation and Cardiovascular Risk Prediction Based on Coronary CT Angiography-Analysis From the CREATION Registry. (Circulation. Cardiovascular imaging) Full episode page: https://podcast.explainheart.com/podcast/ai-boosts-c-t-a-heart-risk-prediction-11-23-25/ Featured Articles Article 1: In vitro approaches to mimic cardiac mechanical load dynamics for enhancing maturation and disease modelling. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41261979 Summary: Human pluripotent stem cell derived cardiomyocytes hold significant promise for in vitro models of the human heart. Achieving full maturation of these cells requires replicating the native cardiac environment, specifically incorporating active mechanical loads such as preload and afterload. These mechanical cues are essential for enhancing cardiomyocyte maturation and improving the utility of these models for disease modeling. This approach represents a critical strategy for advancing the development of more physiologically relevant human heart models. Article 2: S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41268665 Summary: This study found that coronary microvascular hyperpermeability and subsequent inflammation infiltration are key early characteristics of pressure overload-induced myocardial injury. In mice, endothelial-specific deletion of sphingosine-1-phosphate receptor type one (S1PR1) led to severe pressure overload-induced cardiac dysfunction, while S1PR1 overexpression preserved cardiac function. Researchers demonstrated that S1PR1 activation maintained the coronary endothelial barrier by preventing myosin phosphatase target subunit one (MYPT1) ubiquitination and degradation during pressure overload. These findings reveal a critical role for the S1PR1-MYPT1 pathway in preserving coronary endothelial barrier function and cardiac function under pressure overload, identifying S1PR1 as a potential therapeutic target. Article 3: Nobiletin Prevents Cardiac Hypertrophy via SIRT5-Mediated Downregulation of p300. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41268664 Summary: This study found that nobiletin treatment attenuated cardiac hypertrophy and improved systolic dysfunction in mice models of transverse aortic constriction. Nobiletin also improved the survival rate of these mice. Mechanistically, nobiletin significantly downregulated E one A binding protein P300 expression by directly binding to and activating Sirtuin 5, which in turn promoted P300 degradation. These findings identify nobiletin as a potent activator of Sirtuin 5, suggesting its potential as a promising therapeutic agent for heart failure. Article 4: Primary Aldosteronism: Small Molecule Antagonists of Mutant KCNJ5 Potassium Channels. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41263073 Summary: Mutations in the potassium inwardly rectifying channel subfamily J member five (KCNJ5) gene drive aldosterone overproduction in a subset of aldosterone-producing adenomas and familial hyperaldosteronism type three. Researchers identified small molecule compounds that specifically antagonize mutant KCNJ5 channels. Compound three demonstrated specific antagonism of mutant KCNJ5 channels with an inhibitory concentration fifty of 20 nanomolar in electrophysiological studies, showing no activity against wild-type KCNJ5. This compound also inhibited mutant KCNJ5-dependent aldosterone production in human adrenal carcinoma cells, identifying a potent and specific antagonist and a promising therapeutic strategy for primary aldosteronism. Article 5: Machine Learning Model for Atherosclerosis Evaluation and Cardiovascular Risk Prediction Based on Coronary CT Angiography-Analysis From the CREATION Registry. Journal: Circulation. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41268668 Summary: Machine learning models based on coronary computed tomography angiography (C. T. A.) features demonstrated superior performance in predicting

Welcome to Cardiology Today – Recorded November 23, 2025. This episode summarizes 5 key cardiology studies on topics like microwave digestion and hypertension. Key takeaway: Accelerated C. M. R. Boosts C. A. D. Detection Efficiency. Article Links: Article 1: OTUD7a Accelerates Pathological Cardiac Hypertrophy via TAK1 Activation. (Circulation research) Article 2: Accelerated stress CMR for the detection of significant coronary artery disease: a prospective randomized diagnostic accuracy study. (European heart journal. Cardiovascular Imaging) Article 3: Association of Physical Activity with Aortic Stiffness in the Jackson Heart Study. (American journal of hypertension) Article 4: Long-term effect of multivitamin supplementation on incident self-reported hypertension and blood pressure changes in the COSMOS trial. (American journal of hypertension) Article 5: Reducing variability in tissue sodium and potassium measurement: validation of microwave digestion for cardiovascular research. (American journal of physiology. Heart and circulatory physiology) Full episode page: https://podcast.explainheart.com/podcast/accelerated-c-m-r-boosts-c-a-d-detection-efficiency-11-23-25/ Featured Articles Article 1: OTUD7a Accelerates Pathological Cardiac Hypertrophy via TAK1 Activation. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41268652 Summary: OTU domain-containing protein 7a (OTUD7a) accelerates pathological cardiac hypertrophy via Transforming growth factor-beta Activated Kinase 1 (T. A. K. 1) activation. The study demonstrated that OTUD7a expression significantly increased in cardiomyocytes with phenylephrine stimuli and in hearts subjected to transverse aortic constriction surgery. This identifies a specific enzymatic pathway contributing to cardiac hypertrophy, a major cause of heart failure and sudden cardiac death. The findings characterize OTUD7a as a key deubiquitinizing enzyme in this process. Article 2: Accelerated stress CMR for the detection of significant coronary artery disease: a prospective randomized diagnostic accuracy study. Journal: European heart journal. Cardiovascular Imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41264815 Summary: The study demonstrated that an accelerated, stress-only perfusion protocol for cardiovascular magnetic resonance (C. M. R.) achieved non-inferior diagnostic accuracy for detecting significant coronary artery disease. This accelerated protocol significantly improved the time efficiency and cost-effectiveness of C. M. R. procedures. The findings confirm the utility of this advanced imaging approach for patients with suspected coronary artery disease. It supports broader implementation of accelerated C. M. R. to meet increasing demand. Article 3: Association of Physical Activity with Aortic Stiffness in the Jackson Heart Study. Journal: American journal of hypertension PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41273767 Summary: The Jackson Heart Study found a significant association between physical activity and aortic stiffness. Results showed that higher levels of physical activity were linked to lower aortic stiffness. This finding extends previous observations in White populations to a cohort representative of African Americans, where aortic stiffness is an independent predictor of hypertension and cardiovascular disease risk. The data demonstrated that increased physical activity beneficially impacts arterial hemodynamics and vascular aging. Article 4: Long-term effect of multivitamin supplementation on incident self-reported hypertension and blood pressure changes in the COSMOS trial. Journal: American journal of hypertension PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41264477 Summary: The C. O. S. M. O. S. trial demonstrated the long-term effect of multivitamin-multimineral supplementation on incident self-reported hypertension and blood pressure changes. This large-scale, double-blinded randomized controlled trial included 8905 participants, specifically women aged 65 years and older and men aged 60 years and older. The study provided definitive findings on the specific impacts of multivitamin-multimineral use on these cardiovascular parameters. This research confirmed or refuted previous suggestions of a link between multivitamin-multimineral and lower blood pressure. Article 5: Reducing variability in tissue sodium and potassium measurement: validation of microwave digestion for cardiovascular research. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41273776 Summary: The study validated microwave digestion for precise tissue sodium and potassium measurement in cardiovascular research. Results showed that microwave digestion significantly reduced within-sample variability compared to dry ashing for tissue element determination. It also demonstrated that flame atomic emission spectrometry reduced variability compared to inductively coupled plasma optical

Welcome to Cardiology Today – Recorded November 23, 2025. This episode summarizes 5 key cardiology studies on topics like cardiovascular disease and lineage differentiation. Key takeaway: BMAL1 Insufficiency Raises Aortic Dissection Risk. Article Links: Article 1: Loss of GPR146 decreases plasma levels of HDL cholesterol via post-translational upregulation of SR-B1 protein levels. (Cardiovascular research) Article 2: BMAL1 insufficiency increases the risk of thoracic aortic aneurysm and dissection. (Cardiovascular research) Article 3: ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage like foam cells in atherosclerosis. (Cardiovascular research) Article 4: Advances in single-cell transcriptomics: unraveling the pathogenesis of calcific aortic valve disease. (Cardiovascular research) Article 5: Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/bmal1-insufficiency-raises-aortic-dissection-risk-11-23-25/ Featured Articles Article 1: Loss of GPR146 decreases plasma levels of HDL cholesterol via post-translational upregulation of SR-B1 protein levels. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41271608 Summary: Reduced G-protein coupled receptor 146 (GPR146) expression in humans is associated with decreased levels of both low-density lipoprotein and high-density lipoprotein cholesterol. While GPR146 effects on low-density lipoprotein cholesterol involve the E. R. K. /S. R. E. B. P. 2 pathway, this study found the mechanism for high-density lipoprotein cholesterol reduction involves post-translational upregulation of S. R. minus B. 1 protein levels. This provides a direct mechanistic link for GPR146’s role in high-density lipoprotein metabolism. Article 2: BMAL1 insufficiency increases the risk of thoracic aortic aneurysm and dissection. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41270048 Summary: This study found that B. M. A. L. 1 insufficiency increases the risk of thoracic aortic aneurysm and dissection. Vascular smooth muscle cell apoptosis plays a key role in this lethal cardiovascular disease, which has high mortality rates and limited pharmacological therapy. The data established a direct link between insufficient B. M. A. L. 1 and increased susceptibility to thoracic aortic aneurysm and dissection by aggravating vascular smooth muscle cell apoptosis. Article 3: ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage like foam cells in atherosclerosis. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41264461 Summary: This study found that ChemR23 prevents the phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis. Previous findings demonstrated that hematopoietic ChemR23 deficiency reduced atherosclerotic lesions by increasing M two macrophages. The current data specify a critical cell-specific function for ChemR23 by inhibiting this harmful transformation of vascular smooth muscle cells directly contributing to atherosclerosis development. Article 4: Advances in single-cell transcriptomics: unraveling the pathogenesis of calcific aortic valve disease. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41264422 Summary: Single-cell R. N. A. sequencing has revolutionized the study of calcific aortic valve disease. This advanced technique dissects cellular heterogeneity, lineage differentiation, and intercellular crosstalk with unprecedented resolution, revealing novel mechanisms of disease. It also identified new putative therapeutic targets for calcific aortic valve disease, providing a state-of-the-art overview of applications in this research area. Article 5: Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41263385 Summary: This study found that transcription regulation by T. B. X. 18 in smooth muscle cells is essential for normal aortic development and homeostasis. Histological analyses revealed specific T. B. X. 18 expression in smooth muscle cells of both adult and embryonic aortas. The data demonstrated a critical role for T. B. X. 18 in maintaining the integrity and proper formation of this major artery throughout development and into adulthood. Transcript Today’s date is November 23, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Loss of GPR146 decreases plasma levels of HDL cholesterol via post-translational upregulation of SR-B1 protein levels. Reduced G-protein coupled receptor 146 (GPR146) expression in humans is associated with decreased levels of both low-density lipoprotein and high-density lipoprotein

Welcome to Cardiology Today – Recorded November 23, 2025. This episode summarizes 5 key cardiology studies on topics like calcified mitral valve disease and platelet activation. Key takeaway: ALDH2 Variant Drives Thrombosis Risk.. Article Links: Article 1: Clinical Presentation and Mid-Term Results of Mitral Valve Surgery for Calcified Mitral Valve Disease – The MITRACURE registry. (The Canadian journal of cardiology) Article 2: Coronary microvascular dysfunction in patients with acute coronary syndrome and non-obstructive coronary artery disease: a 10-year clinical follow-up study. (International journal of cardiology) Article 3: Vasostatin-2 attenuates injury-induced neointimal hyperplasia through the ACE2/MasR/PPARγ/NR1D1/Gas1 axis. (Cardiovascular research) Article 4: ALDH2 rs671 variant enhances platelet activation and thrombosis by disrupting mitochondrial complex I assembly. (Cardiovascular research) Article 5: Vascular regenerative deficiencies in people with elevated lipoprotein(a): the Lp(a)-VRCE CardioLink-16 translational study. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/aldh2-variant-drives-thrombosis-risk-11-23-25/ Featured Articles Article 1: Clinical Presentation and Mid-Term Results of Mitral Valve Surgery for Calcified Mitral Valve Disease – The MITRACURE registry. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274561 Summary: The MITRACURE registry, a large multicenter observational study conducted in France and Canada, includes 3522 patients. Within this registry, patients diagnosed with calcified mitral valve disease were matched 4 to 1 for age, sex, and concomitant procedures with individuals experiencing myxomatous mitral valve disease. This registry provides real-world information on the characteristics and mid-term outcomes of patients with calcified mitral valve disease undergoing mitral valve surgery, addressing a condition recognized for its specific management challenges. Article 2: Coronary microvascular dysfunction in patients with acute coronary syndrome and non-obstructive coronary artery disease: a 10-year clinical follow-up study. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274583 Summary: Previous studies reported that patients with myocardial infarction and non-obstructive coronary arteries (MINOCA) experienced adverse clinical outcomes. This study specifically assessed coronary blood flow velocity response to ergonovine, adenosine, and the cold pressor test using transthoracic Doppler echocardiography. This non-invasive assessment of coronary functional abnormalities was conducted to determine its predictive value for long-term prognosis over a 10-year clinical follow-up period in this patient population. Article 3: Vasostatin-2 attenuates injury-induced neointimal hyperplasia through the ACE2/MasR/PPARγ/NR1D1/Gas1 axis. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41231769 Summary: Vasostatin-2, a bioactive peptide with established cardiovascular-protective and anti-inflammatory properties, attenuates injury-induced neointimal hyperplasia. This study determined that Vasostatin-2 achieves this attenuation through a specific molecular mechanism involving the Angiotensin-converting enzyme 2, Mas receptor, Peroxisome proliferator-activated receptor gamma, Nuclear Receptor Subfamily 1 Group D Member 1, and Growth arrest specific 1 axis. The research found this peptide influences vascular remodeling following injury and is relevant to restenosis in patients after percutaneous coronary intervention. Article 4: ALDH2 rs671 variant enhances platelet activation and thrombosis by disrupting mitochondrial complex I assembly. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41150615 Summary: The Aldehyde Dehydrogenase 2 rs671 variant, a prevalent loss-of-function mutation observed in 30 to 50 percent of East Asian populations, significantly diminishes Aldehyde Dehydrogenase 2 enzymatic activity by 60 to 90 percent. This variant enhances platelet activation and thrombosis, directly contributing to an elevated thrombotic risk. The study determined that this prothrombotic effect occurs specifically through the disruption of mitochondrial complex one assembly. Article 5: Vascular regenerative deficiencies in people with elevated lipoprotein(a): the Lp(a)-VRCE CardioLink-16 translational study. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40883226 Summary: Elevated lipoprotein(a) directly results in vascular regenerative deficiencies. Lipoprotein(a) is an established causal risk factor for atherosclerotic cardiovascular disease. This study found that elevated levels of lipoprotein(a) modify vascular regenerative cell content properties, impacting the capacity for vascular repair. Depletion of vascular regenerative progenitor cells serves as an indic

Welcome to Cardiology Today – Recorded November 23, 2025. This episode summarizes 5 key cardiology studies on topics like low-density lipoprotein cholesterol and ventricular arrhythmias. Key takeaway: Phenotypic Age Predicts Sudden Cardiac Arrest.. Article Links: Article 1: Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database. (European heart journal) Article 2: Efficacy and Safety of Fetal Magnetocardiography for Detecting Fetal Cardiac Magnetic Signals: A Two-Center, Single-Arm, Prospective Clinical Trial (FAMILY). (Heart rhythm) Article 3: Association of phenotypic age acceleration with risk of sudden cardiac arrest: evidence from a large retrospective cohort. (Heart rhythm) Article 4: Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex. (Heart rhythm) Article 5: Equity in Heart Failure Care: Examining the Area-based Marginalization Status of Patients in an RPM Program. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/phenotypic-age-predicts-sudden-cardiac-arrest-11-23-25/ Featured Articles Article 1: Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40331569 Summary: Higher levels of lipoprotein(a) are established as increasing atherosclerotic cardiovascular disease risk in otherwise healthy individuals, irrespective of sex and race or ethnicity. This study analyzed 273770 individuals from a U. S. medical claims database with diagnosed atherosclerotic cardiovascular disease and measured lipoprotein(a) levels. The research confirmed the clinical significance of lipoprotein(a) as a crucial driver for recurrent atherosclerotic cardiovascular events. It also assessed the influence of low-density lipoprotein cholesterol-lowering therapy on this relationship in patients with established disease. Article 2: Efficacy and Safety of Fetal Magnetocardiography for Detecting Fetal Cardiac Magnetic Signals: A Two-Center, Single-Arm, Prospective Clinical Trial (FAMILY). Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274325 Summary: Fetal magnetocardiography provides precise, non-invasive detection of fetal cardiac electrical activity, which conventional echocardiography cannot record. The F. A. M. I. L. Y. clinical trial evaluated the efficacy and safety of fetal magnetocardiography for detecting fetal cardiac magnetic signals. This two-center, single-arm, prospective study confirmed fetal magnetocardiography’s capability for accurate detection of fetal cardiac time intervals, essential for diagnosing arrhythmias. The research established fetal magnetocardiography as a vital tool by directly comparing its performance with fetal electrocardiography. Article 3: Association of phenotypic age acceleration with risk of sudden cardiac arrest: evidence from a large retrospective cohort. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274324 Summary: This large retrospective cohort analysis of 360663 U. K. Biobank participants found a significant association between phenotypic age acceleration and the risk of incident sudden cardiac arrest. The study established phenotypic age acceleration as a convenient proxy for biological aging and a substantial contributor to cardiovascular disease development. Researchers demonstrated that individuals with higher phenotypic age acceleration face an increased risk of sudden cardiac arrest. This provides crucial evidence for incorporating biological aging markers into risk assessment for sudden cardiac arrest. Article 4: Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274323 Summary: This study defined the electrocardiogram characteristics and ablation outcomes for idiopathic ventricular arrhythmias originating from the right ventricular apex. Researchers conducted a retrospective analysis of patients undergoing catheter ablation for these arrhythmias across three centers. The study provided crucial data distinguishing right ventricular apical ventricular arrhythmias, including premature ventricular contractions and ventricular tachycardia, from other right ventricular sources. The findings contribute to improved diagnostic and therapeutic strategies for this specific and less-understood subset of ventricular arrhythmias. Article 5: Equity in Heart Failure Care: Examining the Area-based Marginalization Status of Patients in an RPM Program. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274562 Summary: This study found that a remote patient management program for heart failure demonstrated equitable accessibility across various area-based marginalization statuses. The program’s design, which provides necessary equipment, employs minimal exclusion criteri

Welcome to Cardiology Today – Recorded November 22, 2025. This episode summarizes 5 key cardiology studies on topics like omics sciences and retrospective cohort study. Key takeaway: Carotid Stenosis: Revascularize or Meds?. Article Links: Article 1: Medical Management and Revascularization for Asymptomatic Carotid Stenosis. (The New England journal of medicine) Article 2: Coronary revascularization: a long-term perspective. (European heart journal) Article 3: Indirect mitral annuloplasty in patients with reduced or preserved ejection fraction: A real-world, single-centre experience. (ESC heart failure) Article 4: Rationales Behind Physiology-Guided Revascularization: Diagnostic Impact of Quantitative Flow Ratio in the FAVOR III China Trial. (JACC. Cardiovascular interventions) Article 5: Cardiac Risk Factors in Drug-Resistant Tuberculosis Patients on Bedaquiline: A Retrospective Cohort Study. (Cardiology) Full episode page: https://podcast.explainheart.com/podcast/carotid-stenosis-revascularize-or-meds-11-22-25/ Featured Articles Article 1: Medical Management and Revascularization for Asymptomatic Carotid Stenosis. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41269206 Summary: The clinical approach for asymptomatic carotid stenosis remains uncertain, particularly whether revascularization offers benefits beyond intensive medical management alone. Two parallel, observer-blinded clinical trials were conducted to address this critical question. These trials enrolled patients with high-grade (70 percent or greater) asymptomatic carotid stenosis across 155 centers in five countries. The research directly compared stenting or endarterectomy against intensive medical management to determine optimal patient care strategies. Article 2: Coronary revascularization: a long-term perspective. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41271218 Summary: This paper provided a long-term perspective on advancements in coronary revascularization, building on successful predictions made in 2000 regarding innovations like drug-eluting stents and coronary computed tomography angiography. The authors highlighted the evolving landscape of coronary artery disease treatment. They specifically emphasized the transformative role of artificial intelligence and omics sciences. Imagenomics, which integrates imaging and omics, was identified as a key future tool for precision in coronary revascularization by 2040. Article 3: Indirect mitral annuloplasty in patients with reduced or preserved ejection fraction: A real-world, single-centre experience. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41255167 Summary: This single-center retrospective study evaluated the real-world effectiveness and safety of the Carillon Mitral Contour System (C. M. C. S.) for indirect annuloplasty in 204 consecutive patients. The study cohort presented with Heart Failure (H. F.) and moderate or moderate to severe (grade two plus or three plus) secondary mitral regurgitation (S. M. R.), with an average age of 83 years, 68 percent female, and 72 percent having Heart Failure with Reduced Ejection Fraction (H. F. rEF). Echocardiographic variables, B-type natriuretic peptide (B. N. P.) levels, and clinical outcomes were systematically recorded. These comprehensive data were collected at baseline, 6-month, and 1-year follow-up to characterize the treatment’s impact on this specific patient group. Article 4: Rationales Behind Physiology-Guided Revascularization: Diagnostic Impact of Quantitative Flow Ratio in the FAVOR III China Trial. Journal: JACC. Cardiovascular interventions PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41263729 Summary: Physiology-guided percutaneous coronary intervention (P. C. I.) is known to offer clinical benefits by optimizing treatment plans beyond what coronary angiography alone can achieve. This study investigated the diagnostic impact of quantitative flow ratio (Q. F. R.) within this framework. A post hoc analysis of the multicenter randomized F. A. V. O. R. three China Trial focused on patients with coronary artery disease. The research explored how quantitative flow ratio contributes to enhancing the precision of interventional strategies. Article 5: Cardiac Risk Factors in Drug-Resistant Tuberculosis Patients on Bedaquiline: A Retrospective Cohort Study. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41269907 Summary: Bedaquiline significantly improves treatment outcomes in patients with drug-resistant tuberculosis (D. R. T. B.), but it is known to prolong the Q. T. interval, necessitating thorough cardiac safety evaluation. This retrospective cohort study assessed the cardiac safety profile of Bedaquiline-containing regimens. It included 202 patients diagnosed with drug-resistant tuberculosis who received treatment between March 2019 and May 2024. Patients were followed for 180 days to gather data on cardia

Welcome to Cardiology Today – Recorded November 21, 2025. This episode summarizes 5 key cardiology studies on topics like mortality and blood pressure. Key takeaway: CAR T Cells Halt Atherosclerosis. Article Links: Article 1: OxLDL-Targeted Chimeric Antigen Receptor T Regulatory Cells Reduce Atherosclerotic Plaque Development. (Circulation) Article 2: Blood Pressure in Adolescence and Atherosclerosis in Middle Age. (JAMA cardiology) Article 3: Patient characteristics, valve surgery and 1-year mortality in left-sided Staphylococcus aureus infective endocarditis: a nationwide study. (Heart (British Cardiac Society)) Article 4: Diagnostic performance of 2023 endocarditis criteria in patients with and without cardiac implantable electronic devices. (Heart (British Cardiac Society)) Article 5: Percutaneous ventricular assist devices for percutaneous coronary interventions in older patients with heart failure: a target trial emulation. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/car-t-cells-halt-atherosclerosis-11-21-25/ Featured Articles Article 1: OxLDL-Targeted Chimeric Antigen Receptor T Regulatory Cells Reduce Atherosclerotic Plaque Development. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41268661 Summary: This study found that oxidized low-density lipoprotein targeted chimeric antigen receptor T regulatory cells reduced atherosclerotic plaque development. This novel approach represents a significant therapeutic advance for cardiovascular disease, which is driven by oxidized low-density lipoprotein accumulation and foam cell formation. The findings suggest a new medical therapy for patients ineligible for percutaneous interventions, addressing a major unmet need in atherosclerosis treatment. Article 2: Blood Pressure in Adolescence and Atherosclerosis in Middle Age. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41259058 Summary: This study found a significant association between elevated systolic and diastolic blood pressure during adolescence and the development of atherosclerosis in middle age. The findings demonstrated that elevated adolescent blood pressure is linked to long-term subclinical atherosclerotic cardiovascular disease. This highlights the critical importance of early blood pressure management to mitigate future cardiovascular risk. Article 3: Patient characteristics, valve surgery and 1-year mortality in left-sided Staphylococcus aureus infective endocarditis: a nationwide study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41266240 Summary: A nationwide study characterized patient profiles and one-year mortality rates for left-sided Staphylococcus aureus infective endocarditis, a condition known for 30 percent to 40 percent in-hospital mortality. The research demonstrated the comparative outcomes between patients who underwent valve surgery and those who received medical therapy alone. These findings offer robust evidence essential for refining current guidelines on surgical intervention in Staphylococcus aureus infective endocarditis. Article 4: Diagnostic performance of 2023 endocarditis criteria in patients with and without cardiac implantable electronic devices. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41218924 Summary: This multicenter cohort study evaluated the diagnostic performance of the 2023 European Society of Cardiology criteria for infective endocarditis. The findings demonstrated how these new criteria performed compared to the 2015 European Society of Cardiology, 2019 European Heart Rhythm Association, and 2023 Duke-International Society for Cardiovascular Infectious Diseases classifications. This assessment of diagnostic accuracy was conducted in patients with and without cardiac implantable electronic devices, providing critical insights for clinical application. Article 5: Percutaneous ventricular assist devices for percutaneous coronary interventions in older patients with heart failure: a target trial emulation. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41218925 Summary: This target trial emulation investigated the utility of percutaneous ventricular assist devices for hemodynamic support during percutaneous coronary interventions (P. C. I.) in older patients with heart failure (H. F.). The study’s results demonstrated the specific outcomes associated with percutaneous ventricular assist device use in Medicare beneficiaries aged 65 to 99 years who had systolic H. F. and coronary artery disease. These findings provide crucial data to inform clinical decision-making for P. C. I. in this high-risk patient group. Transcript Today’s date is November 21, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. OxLDL-Targeted Chimeric Antigen Receptor T Regulatory Cells Reduce Atherosclerotic Plaque Developme

Welcome to Cardiology Today – Recorded November 21, 2025. This episode summarizes 5 key cardiology studies on topics like Transthyretin amyloidosis and Surgical aortic valve replacement. Key takeaway: Cardiac Amyloid Treatment Boosts AVR Outcomes.. Article Links: Article 1: Belzutifan for Advanced Pheochromocytoma or Paraganglioma. (The New England journal of medicine) Article 2: Lipoprotein(a) and risk of dementia: findings from three cohort studies. (European heart journal) Article 3: Artificial intelligence-enhanced electrocardiography to predict regurgitant valvular heart diseases: an international study. (European heart journal) Article 4: Carbon emission analysis of aortic valve replacement: the environmental footprint of transcatheter vs. surgical procedures. (European heart journal) Article 5: Cardiac transthyretin amyloidosis treatment improves outcomes after aortic valve replacement for severe stenosis. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/cardiac-amyloid-treatment-boosts-avr-outcomes-11-21-25/ Featured Articles Article 1: Belzutifan for Advanced Pheochromocytoma or Paraganglioma. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41124218 Summary: Belzutifan is a hypoxia-inducible factor 2 alpha (HIF-2 alpha) inhibitor. This medication targets dysregulation of the HIF-2 alpha pathway, which drives most cases of metastatic pheochromocytoma and paraganglioma. It offers antitumor activity for patients with advanced pheochromocytoma or paraganglioma. This phase two international single-group trial included 72 participants with locally advanced disease. Article 2: Lipoprotein(a) and risk of dementia: findings from three cohort studies. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40824531 Summary: High lipoprotein(a) is a recognized causal risk factor for atherosclerotic cardiovascular disease. This study investigated the association between lipoprotein(a) levels and the risk of Alzheimer’s disease or vascular-related dementia. It analyzed lipoprotein(a) measurements from 539478 individuals across three large cohort studies, including the Copenhagen General Population Study and the Copenhagen City Heart Study. The findings clarify the role of lipoprotein(a) in dementia, especially significant given that lipoprotein(a) lowering drugs are currently in clinical trials. Article 3: Artificial intelligence-enhanced electrocardiography to predict regurgitant valvular heart diseases: an international study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40669514 Summary: Artificial intelligence-enhanced electrocardiography (AI-E. C. G.) models were developed to diagnose and predict future moderate or severe regurgitant valvular heart diseases. These regurgitant valvular heart diseases include mitral regurgitation, tricuspid regurgitation, and aortic regurgitation. The A. I. E. C. G. models were developed using a large dataset of 988618 electrocardiogram and transthoracic echocardiogram pairs. This development provides a tool to potentially improve outcomes through earlier intervention for significant valvular heart disease. Article 4: Carbon emission analysis of aortic valve replacement: the environmental footprint of transcatheter vs. surgical procedures. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40599126 Summary: surgical procedures. A life cycle assessment calculated the carbon emissions associated with open surgical aortic valve replacement (S. A. V. R.) and transcatheter aortic valve replacement (TAVR). The analysis compared procedures performed in the operating room and the cardiac catheterization lab. The total carbon footprint was determined for 10 S. A. V. R. cases, 10 operating room TAVR cases, and 10 cardiac catheterization lab TAVR cases. This study provides a foundational understanding of the environmental footprint of these critical cardiovascular procedures. Article 5: Cardiac transthyretin amyloidosis treatment improves outcomes after aortic valve replacement for severe stenosis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40452225 Summary: Concomitant aortic stenosis and transthyretin-associated cardiac amyloidosis is an increasingly recognized cause of structural heart failure. Aortic valve replacement improves prognosis in this patient population. This study investigated the prognostic implications of transthyretin-associated cardiac amyloidosis-specific medication in patients with both aortic stenosis and cardiac amyloidosis. It found that transthyretin-associated cardiac amyloidosis treatment improves outcomes after aortic valve replacement for severe stenosis. Transcript Today’s date is November 21, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Belzutifan for Advanced Pheochromocytoma or Paraganglioma. Belzutifan is

Welcome to Cardiology Today – Recorded November 20, 2025. This episode summarizes 5 key cardiology studies on topics like angiography and heart failure hospitalization. Key takeaway: Aspirin Elimination Cuts LVAD Bleeding Risk. Article Links: Article 1: Cardiac endogenous transmitter system: molecular features, functions, and clinical implications. (European heart journal) Article 2: Optical coherence tomography-guided stent optimization for complex coronary lesions: the OCCUPI trial. (European heart journal) Article 3: Phase I Randomized Study of Cardiac Stem Cells in Patients With Hypoplastic Left Heart Syndrome: The CHILD Trial. (JACC. Heart failure) Article 4: Hemocompatibility Outcomes With Pharmacological Therapy Following LVAD Implantation: Insights From the ARIES-HM3 Trial. (JACC. Heart failure) Article 5: Heart Failure With Preserved Ejection Fraction Across the Spectrum of Body Mass Index: Hemodynamic and Echocardiographic Characteristics and Outcomes. (JACC. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/aspirin-elimination-cuts-lvad-bleeding-risk-11-20-25/ Featured Articles Article 1: Cardiac endogenous transmitter system: molecular features, functions, and clinical implications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41259103 Summary: Recent studies have identified several endogenous transmitter systems within cardiomyocytes and cardiac pacemaker cells, overturning the traditional belief that the heart lacked its own intrinsic signaling networks. These systems represent molecular networks that facilitate signal transmission directly within cardiac tissues. This discovery reveals that the heart possesses its own distinct intrinsic networks for transmitting signals. The findings provide novel insights into cardiac physiology and potential targets for therapeutic interventions. Article 2: Optical coherence tomography-guided stent optimization for complex coronary lesions: the OCCUPI trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41259082 Summary: The OCCUPI trial investigated the impact of optical coherence tomography guidance compared to angiography guidance in patients with complex coronary lesions. This study classified patients who underwent optical coherence tomography-guided percutaneous coronary intervention into two groups based on meeting specific optimization criteria. This classification system enabled the detailed evaluation of the incidence, determinants, and clinical impact of stent optimization. The trial established a structured approach for assessing optimal stent placement using advanced imaging techniques. Article 3: Phase I Randomized Study of Cardiac Stem Cells in Patients With Hypoplastic Left Heart Syndrome: The CHILD Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41258851 Summary: Patients with hypoplastic left heart syndrome frequently experience severe right ventricle dysfunction, often leading to shortened lifespans. Neonatal cardiac progenitor cells previously demonstrated improved right ventricle performance in animal models of pressure-overload induced dysfunction. The C. H. I. L. D. trial, a phase one randomized study, specifically applied this therapeutic strategy to patients with hypoplastic left heart syndrome. This trial represents a key step in evaluating autologous neonatal cardiac progenitor cells for enhancing right ventricle function in this vulnerable pediatric group. Article 4: Hemocompatibility Outcomes With Pharmacological Therapy Following LVAD Implantation: Insights From the ARIES-HM3 Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41258850 Summary: The Antiplatelet Removal and Hemocompatibility Events With the HeartMate three Pump trial demonstrated both safety and decreased bleeding by eliminating aspirin from the antithrombotic regimen for patients implanted with a HeartMate three left ventricular assist device. This finding established a crucial clinical protocol for reducing adverse events in these patients. This specific trial analysis further investigated associations between various pharmacologic therapies and hemocompatibility outcomes following left ventricular assist device implantation. Article 5: Heart Failure With Preserved Ejection Fraction Across the Spectrum of Body Mass Index: Hemodynamic and Echocardiographic Characteristics and Outcomes. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41258849 Summary: The clinical presentation of heart failure with preserved ejection fraction varies across the spectrum of body mass index. This study established the relationship between body mass index and specific echocardiographic and hemodynamic characteristics in these patients. It also defined the association between body mass index and clinical outcomes, including heart failure hospitalization and death. This analysis utilized a large multicenter regi

Welcome to Cardiology Today – Recorded November 19, 2025. This episode summarizes 5 key cardiology studies on topics like heart failure and stroke. Key takeaway: ECG Abnormalities Predict Heart Failure Risk. Article Links: Article 1: Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes. (Heart (British Cardiac Society)) Article 2: Estimating 5-year absolute risk of cardiovascular disease using routinely collected electronic medical records from Australian general practices. (Heart (British Cardiac Society)) Article 3: Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts. (Heart (British Cardiac Society)) Article 4: Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study. (ESC heart failure) Article 5: Impact of Left Atrial v-Wave Following Mitral Edge-to-Edge Repair on Survival: The MITRA-PRO Registry. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/ecg-abnormalities-predict-heart-failure-risk-11-19-25/ Featured Articles Article 1: Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249037 Summary: Isolated non-specific S. T. T. abnormalities on electrocardiograms were found to be associated with an increased risk of incident coronary heart disease and stroke in participants free of these conditions at baseline. This study also found that these abnormalities were linked to an increased risk of incident heart failure and its subtypes. Data showed that these specific electrocardiographic patterns, defined by Minnesota E. C. G. classification, independently predicted future development of heart failure, including both heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. These findings establish a prognostic role for isolated non-specific S. T. T. abnormalities in identifying individuals at risk for future cardiovascular events and heart failure. Article 2: Estimating 5-year absolute risk of cardiovascular disease using routinely collected electronic medical records from Australian general practices. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249035 Summary: This study demonstrated the feasibility and performance of using routinely collected electronic medical records from Australian general practices to estimate the 5-year absolute risk of cardiovascular disease. Researchers found that integrating primary care electronic medical record data, specifically from the New South Wales Health Lumos program, provided a viable approach for cardiovascular risk prediction. The study successfully utilized data from 680 general practices to assess the predictive capability of these records. These findings indicate that Australian healthcare systems can effectively leverage existing electronic medical records for robust cardiovascular disease risk estimation, comparable to methods used in the U. S. A. and U. K. Article 3: Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41249034 Summary: This study demonstrated the comparative diagnostic accuracy of several tools for heart failure with preserved ejection fraction (H. F. pEF) across community and clinical cohorts. Researchers found that the Heart Failure Association-P. E. F. F. and H. two F. P. E. F. Scores showed differing diagnostic performance when compared against inclusion criteria from sodium-glucose cotransporter-two inhibitors trials and age-adjusted N-terminal pro B-type natriuretic peptide. The data provided clarification on the strengths and limitations of each diagnostic approach, particularly highlighting their utility in older adult populations where H. F. pEF diagnosis is most challenging. These findings contribute to refining the clinical algorithm for accurate identification of H. F. pEF. Article 4: Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41243130 Summary: This prospective cohort study identified significant therapy gaps in the contemporary management of patients with heart failure and reduced kidney function. Researchers evaluated longitudinal treatment patterns over two years in 1401 heart failure patients, finding that the use and dose intensity of guideline-directed heart failure therapies varied considerably across the spectrum of kidney function and left ventricular ejection fraction. The data demonstrated that a substantial proportion of patients with kidney dysfunction did not receive optimal heart failure pharm

Welcome to Cardiology Today – Recorded November 18, 2025. This episode summarizes 5 key cardiology studies on topics like precision medicine and temporal trends. Key takeaway: Cirrhotic Cardiomyopathy Predicts Post-Transplant Heart Failure. Article Links: Article 1: CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes. (Circulation) Article 2: Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study. (European heart journal) Article 3: Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. (European heart journal) Article 4: Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation. (Transplantation) Article 5: Role of physician assistants and their impact on cardiology specialty training in the United Kingdom. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/cirrhotic-cardiomyopathy-predicts-post-transplant-heart-failure-11-18-25/ Featured Articles Article 1: CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251000 Summary: The study demonstrated that CD4 positive T regulatory cells regulate heart growth and regeneration. This regulation occurs through M. R. G. fifteen / T. I. P. sixty mediated epigenomic remodeling within proliferating cardiomyocytes. The chromatin regulatory network was found to be crucial in orchestrating the dynamic changes in gene expression for the regenerative response in the neonatal heart. These findings provide a deeper understanding of the mechanisms controlling heart regeneration, which is critical for addressing limited regenerative capacity in the adult mammalian heart. Article 2: Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251006 Summary: This nationwide Danish study analyzed temporal trends in the use of oral anticoagulants and associated clinical outcomes in older patients with new-onset atrial fibrillation. The study found that anticoagulation therapy patterns in patients with atrial fibrillation have evolved significantly over time, especially following the introduction of direct oral anticoagulants. The analysis investigated how these changes in anticoagulant uptake have impacted clinical outcomes across older adults (65-74 years), elderly (75-84 years), and very elderly (85 years and older) patient groups. This provides critical information on how treatment strategies and patient prognoses for atrial fibrillation have shifted in an aging population. Article 3: Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251004 Summary: The study demonstrated that automated patch clamp data significantly improves the classification of S. C. N. five A variants and penetrance stratification for Brugada Syndrome. This approach addresses complications in genetic workup arising from S. C. N. five A variants of uncertain significance and incomplete penetrance. The deployment of an S. C. N. five A Brugada Syndrome functional assay at a cohort scale was found to facilitate the implementation of genetic and precision medicine for this inherited arrhythmia disorder. These findings refine the diagnostic and risk stratification process for the approximately 20 percent of Brugada Syndrome patients with rare S. C. N. five A variants. Article 4: Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41247366 Summary: This retrospective cohort study found that cirrhotic cardiomyopathy predicts new-onset heart failure within the first year following liver transplantation. The study identified an association between cirrhotic cardiomyopathy, defined using the Cirrhotic Cardiomyopathy Consortium 2020 criteria, and major adverse cardiovascular events after liver transplantation. This established the significant impact of cirrhotic cardiomyopathy on post-transplant cardiac outcomes. These results demonstrate that pre-transplant cardiac assessment for cirrhotic cardiomyopathy is crucial for identifying patients at high risk for developing heart failure after liver transplantation. Article 5: Role of physician assistants and their impact on cardiology specialty training in the United Kingdom. Journal: Heart (British Cardiac Society) PubMed Link: ht

Welcome to Cardiology Today – Recorded November 18, 2025. This episode summarizes 5 key cardiology studies on topics like type two diabetes and semaglutide. Key takeaway: Semaglutide Improves Peripheral Artery Disease. Article Links: Article 1: Sex Differences in Effectiveness of Semaglutide in Patients With Peripheral Artery Disease: The STRIDE Trial. (Journal of the American College of Cardiology) Article 2: Natriuretic Peptides, Body Mass Index, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. (Journal of the American College of Cardiology) Article 3: Anthropometric Measures, Cardiovascular Outcomes, and Treatment Effects of Finerenone in Cardiovascular-Kidney-Metabolic Disease: Pooled Participant-Level Analysis of 3 Global Trials. (Journal of the American College of Cardiology) Article 4: Adiposity-Related Anthropometrics and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Participant-Level Pooled Analysis of Randomized Clinical Trials. (Journal of the American College of Cardiology) Article 5: Adult Heart Transplant Survival in the United States: Regional and Racial Disparities From 2002 to 2022. (Transplantation) Full episode page: https://podcast.explainheart.com/podcast/semaglutide-improves-peripheral-artery-disease-11-18-25/ Featured Articles Article 1: Sex Differences in Effectiveness of Semaglutide in Patients With Peripheral Artery Disease: The STRIDE Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40892617 Summary: The STRIDE trial established that semaglutide 1.0 mg improved functional outcomes and health-related quality of life in patients with early symptomatic peripheral artery disease and type two diabetes. Sex-based differences are recognized in the epidemiology, clinical presentation, and outcomes of peripheral artery disease. This study explored how these existing sex differences might influence the effectiveness of semaglutide treatment in this patient population. Understanding these differential responses provides key clinical insights for optimizing individualized treatment strategies. Article 2: Natriuretic Peptides, Body Mass Index, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40892613 Summary: N-terminal pro-B-type natriuretic peptide is a key biomarker in heart failure guidelines for risk stratification and trial eligibility. Standard threshold levels for these natriuretic peptides typically do not incorporate measures of adiposity, such as body mass index. This gap in risk assessment highlights a significant clinical challenge in patients with heart failure with mildly reduced or preserved ejection fraction. Understanding the interplay between natriuretic peptide levels, body mass index, and clinical outcomes is crucial for more precise patient management. Article 3: Anthropometric Measures, Cardiovascular Outcomes, and Treatment Effects of Finerenone in Cardiovascular-Kidney-Metabolic Disease: Pooled Participant-Level Analysis of 3 Global Trials. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40892605 Summary: Obesity is a core pathophysiologic contributor to cardiovascular, kidney, and metabolic conditions. The association between various adiposity-related anthropometric measures and cardiovascular outcomes in this patient population remains an area requiring rigorous investigation. This pooled analysis of three global trials specifically investigated how different anthropometrics relate to cardiovascular outcomes and the efficacy of finerenone treatment. This research provides crucial information for understanding patient-specific responses to therapy in cardiovascular-kidney-metabolic disease. Article 4: Adiposity-Related Anthropometrics and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Participant-Level Pooled Analysis of Randomized Clinical Trials. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40864017 Summary: Obesity is highly prevalent among individuals with heart failure with mildly reduced ejection fraction or heart failure with preserved ejection fraction. This prevalence directly correlates with an increased risk of disability and death in affected patients. This comprehensive pooled analysis of five international randomized trials explored the detailed association between different adiposity-related anthropometrics and clinical outcomes in this specific patient population. Such data clarifies the prognostic significance of various body composition measures for targeted interventions in heart failure. Article 5: Adult Heart Transplant Survival in the United States: Regional and Racial Disparities From 2002 to 2022. Journal: Transplantat

Welcome to Cardiology Today – Recorded November 17, 2025. This episode summarizes 5 key cardiology studies on topics like right heart function and immunoglobulin light chain cardiac amyloidosis. Key takeaway: New Echo Index Guides Amyloidosis Prognosis.. Article Links: Article 1: Duration of atrial fibrillation and cardiac biomarkers are associated with cardiovascular outcomes in early permanent atrial fibrillation: Data from the RACE II study. (International journal of cardiology) Article 2: High admission levels of interleukin-1 receptor antagonist in acute myocardial infarction patients are associated with increased rates of all-cause mortality and cardiac death at five years follow-up. (International journal of cardiology) Article 3: Impact of diagnosis-to-ablation time on rhythm outcome after catheter ablation for paroxysmal versus non-paroxysmal atrial fibrillation. (International journal of cardiology) Article 4: Global and segmental longitudinal and radial strain in Takotsubo versus ST-elevation myocardial infarction. (International journal of cardiology) Article 5: Usefulness of STREI: A new index of right heart function in patients with immunoglobulin light chain cardiac amyloidosis. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/new-echo-index-guides-amyloidosis-prognosis-11-17-25/ Featured Articles Article 1: Duration of atrial fibrillation and cardiac biomarkers are associated with cardiovascular outcomes in early permanent atrial fibrillation: Data from the RACE II study. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40716680 Summary: A post-hoc analysis of the RACE two study found that the duration of atrial fibrillation and specific cardiac biomarkers are directly associated with cardiovascular morbidity and mortality in patients with early permanent atrial fibrillation. Data from 543 patients, who had a median atrial fibrillation duration of 18 months, demonstrated these associations. The study identified these parameters as definitive prognostic indicators for adverse cardiovascular outcomes. These findings underscore the clinical importance of assessing atrial fibrillation duration and cardiac biomarker levels for risk stratification in early permanent atrial fibrillation. Article 2: High admission levels of interleukin-1 receptor antagonist in acute myocardial infarction patients are associated with increased rates of all-cause mortality and cardiac death at five years follow-up. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40716679 Summary: This study found that high admission levels of interleukin-1 receptor antagonist are associated with increased rates of both all-cause mortality and cardiac death in patients with acute myocardial infarction. The data demonstrated these elevated levels were linked to adverse outcomes at five years follow-up. This concrete association suggests interleukin-1 receptor antagonist serves as a prognostic biomarker for long-term cardiovascular risk in this patient population. Article 3: Impact of diagnosis-to-ablation time on rhythm outcome after catheter ablation for paroxysmal versus non-paroxysmal atrial fibrillation. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40712675 Summary: This study found that diagnosis-to-ablation time significantly impacts rhythm outcome following catheter ablation for atrial fibrillation. The research differentiated this impact between paroxysmal and non-paroxysmal atrial fibrillation types among 619 enrolled patients. Results indicated that the timing of intervention relative to diagnosis plays a crucial role in the success of initial catheter ablation procedures. This finding provides direct guidance for optimizing treatment strategies based on atrial fibrillation type. Article 4: Global and segmental longitudinal and radial strain in Takotsubo versus ST-elevation myocardial infarction. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40712674 Summary: T. elevation myocardial infarction. This study compared global and segmental longitudinal and radial strain between Takotsubo syndrome and S. T. elevation myocardial infarction patients. Results demonstrated distinct patterns of myocardial strain in Takotsubo syndrome, which contribute to the observed milder symptoms and better hemodynamic profile compared to S. T. elevation myocardial infarction. The data showed that these differences in strain were not readily apparent using conventional echocardiography alone. These findings offer a more comprehensive understanding of the mechanisms underlying cardiac dysfunction in Takotsubo syndrome. Article 5: Usefulness of STREI: A new index of right heart function in patients with immunoglobulin light chain cardiac amyloidosis. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.g

Welcome to Cardiology Today – Recorded November 17, 2025. This episode summarizes 5 key cardiology studies on topics like cardiac phenotype and S. L. C. 6 A. 8 variants. Key takeaway: ElectroPulse PFA: First-in-Human Data. Article Links: Article 1: Prominent U-waves Without QT Prolongation in X-linked Creatine Transporter Deficiency Caused by SLC6A8 Variants. (Heart rhythm) Article 2: Update on First-in-Human Experience of High-Energy ElectroPulse Pulsed Field Ablation. (Heart rhythm) Article 3: Atrioventricular Block After Transcatheter Atrial Septal Defect Closure: Comprehensive Short-term to Long-Term Outcome Analysis. (Heart rhythm) Article 4: Device-Based Longitudinal Monitoring of Premature Atrial Contractions Before Atrial Fibrillation Onset. (Heart rhythm) Article 5: Added diagnostic value of Electrophysiological study in new-onset Left Bundle Branch Block after transcatheter aortic valve implantation. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/electropulse-pfa-first-in-human-data-11-17-25/ Featured Articles Article 1: Prominent U-waves Without QT Prolongation in X-linked Creatine Transporter Deficiency Caused by SLC6A8 Variants. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242588 Summary: T. Prolongation in X-linked Creatine Transporter Deficiency Caused by S. L. C. 6 A. 8 Variants. Complete results detailing the cardiac phenotype of male Creatine Transporter Deficiency patients were not available in the abstract. This study focused on characterizing cardiac manifestations in patients with S. L. C. 6 A. 8 variants. Early clinical reports had raised concerns regarding possible associations with Q. T. c. prolongation and dilated cardiomyopathy in this patient population. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article 2: Update on First-in-Human Experience of High-Energy ElectroPulse Pulsed Field Ablation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242587 Summary: Complete results, including specific numerical findings for the primary endpoint, were not available in the abstract. This first-in-human study evaluated mid-term outcomes of the ElectroPulse pulsed field ablation system for pulmonary vein and posterior wall isolation. The trial enrolled 60 patients with symptomatic atrial fibrillation, with two cohorts receiving either a standard or a modified ablation protocol. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article 3: Atrioventricular Block After Transcatheter Atrial Septal Defect Closure: Comprehensive Short-term to Long-Term Outcome Analysis. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242586 Summary: Complete results detailing the incidence, risk factors, and outcomes of atrioventricular block following transcatheter atrial septal defect closure were not available in the abstract. The study retrospectively analyzed 1954 patients who underwent transcatheter atrial septal defect closure between 1999 and 2020 at three tertiary centers. This comprehensive analysis uniquely focused on providing detailed short-term to long-term follow-up. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article 4: Device-Based Longitudinal Monitoring of Premature Atrial Contractions Before Atrial Fibrillation Onset. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242585 Summary: Specific numerical findings regarding the temporal frequency pattern of premature atrial contractions before atrial fibrillation onset were not available in the abstract. This retrospective study utilized long-term monitoring data from cardiovascular implantable electronic devices. It included 101 patients from Boston Scientific devices with a mean follow-up of 5.2 years, divided into groups based on whether they developed atrial fibrillation. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article 5: Added diagnostic value of Electrophysiological study in new-onset Left Bundle Branch Block after transcatheter aortic valve implantation. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242385 Summary: Specific numerical findings on the diagnostic value of electrophysiological study in new-onset left bundle branch block after transcatheter aortic valve implantation were not available in the abstract. This prospective multicenter study included 183 patients who developed new-onset left bundle branch block 24 hours or more after transcatheter aortic valve implantation. The research compared His-ventricular intervals with electrocardiogram parameters to assess diagnostic performance for risk stratification. Therefore, no definitive outcomes from this study can be reported based on the abstract. Transcript Today’s date is November 17, 2025. Welcome to Cardiology Today. Here ar

Welcome to Cardiology Today – Recorded November 17, 2025. This episode summarizes 5 key cardiology studies on topics like selexipag and atrial flutter. Key takeaway: AI Ablation Cuts Persistent AF Recurrence. Article Links: Article 1: Evaluating oral selexipag in PAH: Insights on survival, safety and dosing patterns from the complete observation period of GRIPHON and its open-label extension. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Molecular biopsy features associated with baseline lung allograft dysfunction in a multicenter international cohort. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Pulmonary Artery Fresh Floating Thrombus in Patients with Chronic Thromboembolic Pulmonary Hypertension on Low-Dose Direct Oral Anticoagulants: A Single-Center Angiographic Observational Study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Targetable atrial tachycardias after artificial-intelligence-guided ablation of persistent atrial fibrillation. (Heart rhythm) Article 5: Atrial Arrhythmia Recurrence After the Maze Procedure: Insights from Catheter-based Mapping. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/ai-ablation-cuts-persistent-af-recurrence-11-17-25/ Featured Articles Article 1: Evaluating oral selexipag in PAH: Insights on survival, safety and dosing patterns from the complete observation period of GRIPHON and its open-label extension. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242357 Summary: The GRIPHON study found that oral selexipag, a prostacyclin receptor agonist, significantly reduced morbidity and mortality risk compared to placebo in patients with pulmonary arterial hypertension. Five-year survival estimates for pulmonary arterial hypertension patients in real-world clinical practice were 57 percent. The GRIPHON trial, along with its open-label extension, provided the longest follow-up to date for a pulmonary arterial hypertension trial. Complete results regarding the two main analysis sets were not available in this abstract. Article 2: Molecular biopsy features associated with baseline lung allograft dysfunction in a multicenter international cohort. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242356 Summary: This study examined molecular biopsy features associated with baseline lung allograft dysfunction in an international cohort of lung transplant recipients. Researchers investigated transbronchial biopsy gene expression changes linked to baseline lung allograft dysfunction. Baseline lung allograft dysfunction status was assessed at one-year post-transplant. Specific numerical or definitive results regarding the associations found were not provided in this abstract. Article 3: Pulmonary Artery Fresh Floating Thrombus in Patients with Chronic Thromboembolic Pulmonary Hypertension on Low-Dose Direct Oral Anticoagulants: A Single-Center Angiographic Observational Study. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242355 Summary: This observational study retrospectively analyzed 721 follow-up selective pulmonary angiograms from 239 patients with chronic thromboembolic pulmonary hypertension. All patients completed balloon pulmonary angioplasty and received long-term anticoagulation with low-dose direct oral anticoagulants, standard-dose direct oral anticoagulants, or vitamin K antagonists. The study evaluated baseline characteristics, follow-up outcomes, and the incidence of pulmonary artery fresh floating thrombus. Specific numerical findings regarding these outcomes and comparisons between the anticoagulant regimens were not provided in this abstract. Article 4: Targetable atrial tachycardias after artificial-intelligence-guided ablation of persistent atrial fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242590 Summary: The TAILORED-AF randomized trial demonstrated that artificial intelligence-guided ablation of spatio-temporal dispersion combined with pulmonary vein isolation significantly reduced atrial fibrillation recurrence at one-year follow-up in patients with persistent atrial fibrillation. Despite this, approximately one third of the patient population experienced atrial tachycardia recurrences. The study found that most of these atrial tachycardia recurrences were successfully ablated. This post-hoc analysis identified the

Welcome to Cardiology Today – Recorded November 16, 2025. This episode summarizes 5 key cardiology studies on topics like myocardial performance score and right ventricular failure. Key takeaway: Simplified DCD Heart Tx: 100 percent Graft Function.. Article Links: Article 1: DCD Heart Transplantation Using Simplified Direct Procurement: Expanding Access. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Low Rates of Inotropic Support and Durable Left Ventricular Assist Device Placement among Status 2 Heart Transplant Candidates with Temporary Mechanical Circulatory Support. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Advanced Hemodynamics for Right Ventricular Failure: Evaluating the use of the Myocardial Performance Score. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Ex-vivo Heart Perfusion Attenuates Early Post-Transplant Risk After Prolonged Agonal Period in DCD Heart Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/simplified-dcd-heart-tx-100-percent-graft-function-11-16-25/ Featured Articles Article 1: DCD Heart Transplantation Using Simplified Direct Procurement: Expanding Access. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241036 Summary: This study successfully performed five heart transplantations using a simplified direct procurement technique from donation after circulatory death donors. All five recipients demonstrated normal cardiac graft function after the procedure. No evidence of rejection was observed during their short-term follow-up period. The approach, which employed cold blood perfusion and preservation solution, proved to be both feasible and logistically efficient. Article 2: Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241034 Summary: The Trifecta-Heart study compared four tests used to assess antibody-mediated rejection in heart transplant patients: standard endomyocardial biopsy histology, endomyocardial biopsy molecular analysis using the Molecular Microscope Diagnostic System, donor-derived cell-free D. N. A., and donor-specific antibody measurements. Specific numerical results defining the relationships among these tests were not provided in the abstract. The abstract focused on the comparison of these assessment methods. Article 3: Low Rates of Inotropic Support and Durable Left Ventricular Assist Device Placement among Status 2 Heart Transplant Candidates with Temporary Mechanical Circulatory Support. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241033 Summary: Following the 2018 heart allocation policy change, status two listings for heart transplant candidates with temporary mechanical circulatory support were observed to increase, while listings for durable left ventricular assist devices decreased. The study identified adult heart transplant candidates from the Scientific Registry of Transplant Recipients. Specific numerical data detailing the low rates of inotropic support and durable left ventricular assist device placement were not included in this abstract. Article 4: Advanced Hemodynamics for Right Ventricular Failure: Evaluating the use of the Myocardial Performance Score. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241032 Summary: This study performed 800 pressure-volume loop in silico simulations to evaluate right ventricular myocardial performance. The right ventricular myocardial performance score was precisely calculated using the formula (3 multiplied by pulmonary artery pulsatility index multiplied by right ventricular cardiac power output) divided by 2. A validation cohort comprising 223 patients was included for further assessment. Specific findings re

Welcome to Cardiology Today – Recorded November 15, 2025. This episode summarizes 5 key cardiology studies on topics like ventricular systolic function and congenital heart disease. Key takeaway: Albuminuria and Acute Heart Failure Risk. Article Links: Article 1: Transcriptomic and proteomic profiling shows dysregulated immune and metabolic pathways in arrhythmogenic cardiomyopathy. (ESC heart failure) Article 2: Albuminuria is associated with worse outcomes in non-diabetics hospitalized with acute heart failure. (ESC heart failure) Article 3: Prognostic Determinants in Patients with Secondary Tricuspid Regurgitation Classified by Right Ventricular Systolic Function. (Cardiology) Article 4: Activation of endothelial TRPV4 exacerbates myocardial ischemia-reperfusion injury via vascular integrity impairment. (The Canadian journal of cardiology) Article 5: Echocardiographic Indices of Ventricular Systolic Function in Adults with Fontan Palliation: Feasibility, Reproducibility, and Prognostic Implications. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/albuminuria-and-acute-heart-failure-risk-11-15-25/ Featured Articles Article 1: Transcriptomic and proteomic profiling shows dysregulated immune and metabolic pathways in arrhythmogenic cardiomyopathy. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41229088 Summary: Complete results were not available in the abstract. This study aimed to characterize the myocardial transcriptome and proteome in patients with arrhythmogenic cardiomyopathy. Specific numerical findings on which immune and metabolic pathways were dysregulated, or the detectability of key molecules in plasma and tissue, were not provided. Article 2: Albuminuria is associated with worse outcomes in non-diabetics hospitalized with acute heart failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41224248 Summary: Complete results were not available in the abstract. This study evaluated if albuminuria was associated with adverse outcomes in non-diabetic individuals hospitalized with acute heart failure. Specific numerical findings regarding the association between albuminuria and patient outcomes were not provided. Article 3: Prognostic Determinants in Patients with Secondary Tricuspid Regurgitation Classified by Right Ventricular Systolic Function. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41231743 Summary: Complete results were not available in the abstract. This retrospective study aimed to stratify patients with severe secondary tricuspid regurgitation based on right ventricular fractional area change. Specific echocardiographic parameters influencing prognosis or definitive conclusions on patient stratification were not provided. Article 4: Activation of endothelial TRPV4 exacerbates myocardial ischemia-reperfusion injury via vascular integrity impairment. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41238115 Summary: Complete results were not available in the abstract. This study hypothesized that endothelial transient receptor potential vanilloid 4 contributes to post-ischemic vascular hyperpermeability and myocardial injury. Specific numerical findings demonstrating the exacerbation of ischemia-reperfusion injury or the impairment of vascular integrity were not provided. Article 5: Echocardiographic Indices of Ventricular Systolic Function in Adults with Fontan Palliation: Feasibility, Reproducibility, and Prognostic Implications. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41238114 Summary: Complete results were not available in the abstract. This retrospective cohort study assessed the feasibility and reproducibility of echocardiogram-derived systolic function indices in adults with Fontan palliation. Specific numerical findings on the relationship between these indices and clinical outcomes were not provided. Transcript Today’s date is November 15, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Transcriptomic and proteomic profiling shows dysregulated immune and metabolic pathways in arrhythmogenic cardiomyopathy. Complete results were not available in the abstract. This study aimed to characterize the myocardial transcriptome and proteome in patients with arrhythmogenic cardiomyopathy. Specific numerical findings on which immune and metabolic pathways were dysregulated, or the detectability of key molecules in plasma and tissue, were not provided. Article number two. Albuminuria is associated with worse outcomes in non-diabetics hospitalized with acute heart failure. Complete results were not available in the abstract. This study evaluated if albuminuria was associated with adverse outcomes in non-diabetic individuals hospitalized with acute heart failure. Specific numerical findings regarding the association between albuminuria a

Welcome to Cardiology Today – Recorded November 15, 2025. This episode summarizes 5 key cardiology studies on topics like Transcatheter aortic valve replacement and Heart failure. Key takeaway: PA-Led Heart Transplant Recovery: Safe, Effective. Article Links: Article 1: Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial. (Heart (British Cardiac Society)) Article 3: Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement. (Heart (British Cardiac Society)) Article 4: Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention. (Heart (British Cardiac Society)) Article 5: Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/pa-led-heart-transplant-recovery-safe-effective-11-15-25/ Featured Articles Article 1: Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41238023 Summary: This observational cohort study assessed the clinical outcomes and programmatic benefits of a physician assistant-led allograft recovery model for adult heart transplantation. Researchers compared 130 transplantations using physician assistant teams with 367 using non-physician assistant teams at a high-volume center between 2020 and 2024. The implementation of this physician assistant-led model for donor organ recovery demonstrated comparable clinical outcomes for heart transplantation recipients. This model offers significant programmatic advantages, potentially enhancing efficiency and resource utilization within heart transplantation programs. Article 2: Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40393691 Summary: This subanalysis of the Low-Dose Colchicine 2 Trial aimed to investigate the effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition. Researchers performed cross-sectional computed tomography angiography studies in 151 participants with chronic coronary disease. The primary objective was to understand the underlying mechanisms by which low-dose colchicine, administered at 0.5 mg once daily, reduces the risk of major cardiovascular events. This study established a methodology to assess how colchicine may exert its beneficial anti-inflammatory actions on coronary arteries. Article 3: Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348411 Summary: This prospective registry study investigated the incidence, predictors, and clinical impact of late upper gastrointestinal bleeding following transcatheter aortic valve replacement. Researchers analyzed 3144 patients, stratifying them based on the occurrence of upper gastrointestinal bleeding within one year of hospital discharge. The study characterized the frequency of this complication in transcatheter aortic valve replacement patients and identified specific factors that predict its occurrence. Understanding these predictors is crucial for implementing targeted preventative strategies and improving patient safety after this cardiac procedure. Article 4: Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40312105 Summary: This study determined the incidence, predictors, and clinical outcomes of tricuspid regurgitation progression following left-sided valvular intervention. Researchers analyzed one thousand six hundred forty-four patients who underwent surgical or transcatheter treatment for aortic or mitral valve disease, excluding those with severe tricuspid regurgitation at baseline. The study defined tricuspid regurgitation progression as an increase to at least moderate or severe grade, identifying key factors influencing this critical clinical concern. This research provides es

Welcome to Cardiology Today – Recorded November 14, 2025. This episode summarizes 5 key cardiology studies on topics like ischemic cardiomyopathy and ventricular tachycardia. Key takeaway: Sacubitril-Valsartan for Chemo Cardiotoxicity. Article Links: Article 1: Deferring Arterial Catheterization in Critically Ill Patients with Shock. (The New England journal of medicine) Article 2: Sacubitril-Valsartan for the Prevention of Anthracycline Cardiotoxicity in Patients With Elevated Cardiac Troponin I Concentration During Chemotherapy: A Double-Blind Randomized Placebo-Controlled Clinical Trial: The SARAH Trial. (Circulation) Article 3: Sudden cardiac death in newly diagnosed non-ischaemic or ischaemic cardiomyopathy assessed with a wearable cardioverter-defibrillator: the German nationwide SCD-PROTECT study. (European heart journal) Article 4: Kidney function trajectories before and after hospitalization for heart failure with reduced ejection fraction. (European heart journal) Article 5: Exploring postmortem practices for cardiac device interrogation in the UK. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/sacubitril-valsartan-for-chemo-cardiotoxicity-11-14-25/ Featured Articles Article 1: Deferring Arterial Catheterization in Critically Ill Patients with Shock. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159885 Summary: This multicenter, open-label noninferiority trial investigated whether noninvasive blood pressure monitoring via an automated brachial cuff is an effective alternative to early arterial catheterization for critically ill patients in shock. Patients admitted to an intensive care unit with shock were randomized to receive either an arterial catheter within four hours or to be monitored noninvasively. The study’s objective was to determine if deferring invasive monitoring is noninferior to immediate arterial catheterization. This research establishes a rigorous comparison to potentially guide future management strategies for blood pressure monitoring in this vulnerable population. Article 2: Sacubitril-Valsartan for the Prevention of Anthracycline Cardiotoxicity in Patients With Elevated Cardiac Troponin I Concentration During Chemotherapy: A Double-Blind Randomized Placebo-Controlled Clinical Trial: The SARAH Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41230611 Summary: The SARAH Trial, a randomized double-blind placebo-controlled study, investigated the efficacy of sacubitril-valsartan in preventing anthracycline-induced cardiotoxicity. This trial enrolled 114 patients who developed elevated cardiac troponin I concentrations during anthracycline chemotherapy. The primary objective was to determine if this angiotensin receptor-neprilysin inhibitor could reduce cardiotoxicity in this high-risk population. This research aimed to translate experimental evidence of cardioprotective properties into a clinical benefit for patients undergoing critical cancer treatment. Article 3: Sudden cardiac death in newly diagnosed non-ischaemic or ischaemic cardiomyopathy assessed with a wearable cardioverter-defibrillator: the German nationwide SCD-PROTECT study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40879135 Summary: The German nationwide S. C. D. minus PROTECT study aimed to evaluate the risk of sudden cardiac arrest due to ventricular tachycardia or ventricular fibrillation in patients with newly diagnosed non-ischemic cardiomyopathy or ischemic cardiomyopathy. This study utilized wearable cardioverter-defibrillators in all eligible patients across Germany to assess these events during the critical early phase of guideline-recommended medical therapy initiation and up-titration. The research directly addressed the increased sudden cardiac death risk in this vulnerable population by providing real-world data on event rates observed with temporary defibrillator use. Article 4: Kidney function trajectories before and after hospitalization for heart failure with reduced ejection fraction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40737218 Summary: This study examined kidney function trajectories before and after a heart failure-related event, defined as heart failure hospitalization or heart failure death, in patients with heart failure with reduced ejection fraction. Researchers utilized individual patient data from the EPHESUS and EMPHASIS-H. F. clinical trials, alongside the real-world BARCELONA cohort, to analyze longitudinal changes in estimated glomerular filtration rate. The primary objective was to clarify the associations between these kidney function changes and subsequent heart failure-related events. This comprehensive approach establishes a framework for better understanding the prognostic impact of kidney function dynamics in this patient group. Article 5: Exploring postmortem practices for cardiac

Welcome to Cardiology Today – Recorded November 13, 2025. This episode summarizes 5 key cardiology studies on topics like pediatric cardiology and subclinical atrial fibrillation. Key takeaway: N-Palmitoyl Glutamine: Fitness Mediator. Article Links: Article 1: Quantitative Identification of High-Risk Tricuspid Regurgitation by Cardiac Magnetic Resonance. (Circulation) Article 2: N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness. (Circulation) Article 3: Cellular and molecular imaging of coronary atherosclerosis: clinical applications. (European heart journal) Article 4: Contemporary Waitlist and Post-Heart Transplant Outcomes for Fontan patients: An International Multi-Institutional Analysis. (Journal of cardiac failure) Article 5: Major Bleeding With Apixaban vs Aspirin: A Subanalysis of the ARTESiA Randomized Clinical Trial. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/n-palmitoyl-glutamine-fitness-mediator-11-13-25/ Featured Articles Article 1: Quantitative Identification of High-Risk Tricuspid Regurgitation by Cardiac Magnetic Resonance. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41221593 Summary: This study aimed to assess the prognostic relevance of tricuspid regurgitation quantification and its consequences using cardiac magnetic resonance in a large real-world cohort. Researchers collected comprehensive clinical, echocardiographic, and cardiac magnetic resonance data from patients referred between 2019 and 2024 who underwent tricuspid regurgitant fraction quantification. The study established that cardiac magnetic resonance quantification can quantitatively identify high-risk tricuspid regurgitation patients. This provides a crucial tool for improved risk stratification and management strategies for individuals with tricuspid regurgitation. Article 2: N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41221589 Summary: This study investigated the molecular underpinnings of cardiorespiratory fitness, a key predictor of survival and cardiometabolic health. Researchers employed nontargeted liquid chromatography-mass spectrometry-based plasma metabolomics in 654 participants from the HERITAGE Family Study. The study successfully identified N-Palmitoyl Glutamine as a candidate mediator of cardiorespiratory fitness. This discovery provides a novel molecular target for understanding and potentially enhancing cardiorespiratory health and its benefits. Article 3: Cellular and molecular imaging of coronary atherosclerosis: clinical applications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41222955 Summary: This article reviewed the substantive advances in non-invasive and invasive structural imaging techniques used to delineate atheroma burden and anatomical composition in coronary artery disease. Driven by progress in imaging agent and hardware technology, the review detailed the burgeoning field of cellular and molecular imaging. It comprehensively discussed how these advancements enhance understanding of atherosclerosis pathogenesis and explored their diverse clinical applications. This provides clinicians with critical insights into improved diagnostic capabilities and potential for more targeted therapeutic strategies. Article 4: Contemporary Waitlist and Post-Heart Transplant Outcomes for Fontan patients: An International Multi-Institutional Analysis. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41224169 Summary: This international multi-institutional study provided contemporary data on waitlist and post-heart transplant outcomes for pediatric patients with Fontan circulation. Researchers conducted a retrospective analysis of children aged 2 to less than 18 years listed for heart transplant in the Pediatric Heart Transplant Society database between 1993 and 2023. The study categorized patients by diagnosis, including Fontan circulation, non-Fontan congenital heart disease, and cardiomyopathy. This analysis established vital outcome trends, highlighting that Fontan patients represent a growing and high-risk cohort among heart transplant candidates, offering crucial guidance for clinical decision-making. Article 5: Major Bleeding With Apixaban vs Aspirin: A Subanalysis of the ARTESiA Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41222953 Summary: This prespecified subanalysis of the ARTESiA randomized clinical trial characterized major bleeding events associated with apixaban versus aspirin in patients with device-detected subclinical atrial fibrillation. The main ARTESiA trial previously demonstrated that apixaban reduced stroke and systemic embolism but increased major bleeding compared with aspirin. This subanalysis specifically aimed to detail the site and severity of these major bleeding events and identify associ

Welcome to Cardiology Today – Recorded November 12, 2025. This episode summarizes 5 key cardiology studies on topics like monotherapy and exercise hemodynamics. Key takeaway: Angina Endotypes: Precision Treatment Advances. Article Links: Article 1: miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction. (Circulation) Article 2: Enhanced antigen presentation by macrophages promotes human atherosclerosis progression: therapeutic implications. (European heart journal) Article 3: Endotypes of angina with non-obstructive coronary arteries: a prospective multicentre study. (European heart journal) Article 4: Aspirin or P2Y12 inhibitor monotherapy in atherosclerotic cardiovascular disease? (European heart journal) Article 5: Association of Moderate to Severe Tricuspid Regurgitation With Exercise Hemodynamics and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: Multicenter Study. (Journal of cardiac failure) Full episode page: https://podcast.explainheart.com/podcast/angina-endotypes-precision-treatment-advances-11-12-25/ Featured Articles Article 1: miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41208706 Summary: This study investigated the mechanisms by which myocardial infarction triggers myelopoiesis and exacerbates disease pathology. Researchers induced myocardial infarction in mice and found that platelet-derived extracellular vesicles containing micro-R. N. A. minus 499 augmented inflammatory cell generation and cardiac remodeling. This discovery indicates that micro-R. N. A. minus 499 from platelet extracellular vesicles plays a critical role in promoting adverse cardiac remodeling and identifies a potential therapeutic target. Article 2: Enhanced antigen presentation by macrophages promotes human atherosclerosis progression: therapeutic implications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41217874 Summary: This research explored the role of adaptive immune responses in human atherosclerosis progression. Using R. N. A. sequencing and immunohistochemistry on human atherosclerotic plaques, the study revealed that enhanced antigen presentation by macrophages promotes the disease. This finding highlights the critical involvement of macrophage-driven immune responses in atherosclerosis pathology and suggests novel therapeutic strategies targeting this pathway. Article 3: Endotypes of angina with non-obstructive coronary arteries: a prospective multicentre study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41214896 Summary: This prospective multicenter study aimed to better diagnose and treat angina with non-obstructive coronary arteries, a prevalent myocardial ischemic syndrome. Researchers enrolled consecutive patients undergoing coronary functional testing across nine centers to identify distinct hemodynamic endotypes. The study successfully stratified patients into these endotypes, demonstrating differential responses to specific treatments and thereby establishing a foundation for a precision medicine approach. Article 4: Aspirin or P2Y12 inhibitor monotherapy in atherosclerotic cardiovascular disease? Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211721 Summary: While aspirin has been the traditional cornerstone antiplatelet therapy, the review highlights emerging evidence suggesting P2Y12 inhibitors may be more than just an alternative. The findings suggest that P2Y12 inhibitors may be preferred over aspirin as a single antiplatelet agent, offering a significant therapeutic consideration for clinicians. Article 5: Association of Moderate to Severe Tricuspid Regurgitation With Exercise Hemodynamics and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: Multicenter Study. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41213849 Summary: This multicenter study investigated the clinical significance of moderate to severe tricuspid regurgitation during evaluation for unexplained dyspnea. Researchers assessed 258 patients with exercise heart failure with preserved ejection fraction using exercise right heart catheterization. They found that moderate to severe tricuspid regurgitation was independently associated with worse exercise capacity and adverse five-year clinical outcomes, underscoring its prognostic importance in this patient population. Transcript Today’s date is November 12, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction. This study investigated the mechanisms by which myocardial infarction

Welcome to Cardiology Today – Recorded November 12, 2025. This episode summarizes 5 key cardiology studies on topics like proprotein convertase subtilisin/kexin 9 inhibitor and cardiovascular outcomes. Key takeaway: Oral Bacteria Worsen Heart Attacks via B2 Cells. Article Links: Article 1: Association of Lipoprotein(a) and Interleukin-6 With Cardiovascular Risk: MESA and UK Biobank. (Journal of the American College of Cardiology) Article 2: Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells. (Circulation) Article 3: Coramitug, a Humanized Monoclonal Antibody for the Treatment of Transthyretin Amyloid Cardiomyopathy: a Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial. (Circulation) Article 4: High-Dose vs. Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: The FLUNITY-HD Prespecified Pooled Analysis. (Circulation) Article 5: Cardiac Allograft Vasculopathy Inhibition with Alirocumab: The CAVIAR Trial. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/oral-bacteria-worsen-heart-attacks-via-b2-cells-11-12-25/ Featured Articles Article 1: Association of Lipoprotein(a) and Interleukin-6 With Cardiovascular Risk: MESA and UK Biobank. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41217319 Summary: The study aimed to evaluate if interleukin-6, a biomarker of inflammation, helps to further stratify atherosclerotic cardiovascular disease risk in individuals with elevated lipoprotein(a). Researchers utilized data from 6514 participants in the Multi-Ethnic Study of Atherosclerosis and 26574 participants from the U. K. Biobank. This research sought to identify if vascular inflammation, as indicated by interleukin-6 levels, provides additional insights into cardiovascular risk associated with high lipoprotein(a). Such findings could refine risk assessment and guide targeted preventative strategies for patients with elevated lipoprotein(a). Article 2: Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40859845 Summary: This study investigated how oral pathobionts worsen myocardial infarction, addressing the unclear direct impact of periodontitis. Researchers utilized a mouse model combining ligature-induced periodontitis with myocardial infarction to assess this connection. They discovered that oral pathobionts accumulate ectopically in the heart and aggravate myocardial infarction through the mobilization of B2 cells. These findings elucidate a novel pathogenic mechanism linking periodontitis to myocardial infarction, highlighting the importance of oral health in cardiovascular disease. Article 3: Coramitug, a Humanized Monoclonal Antibody for the Treatment of Transthyretin Amyloid Cardiomyopathy: a Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41212997 Summary: This phase two randomized, multicenter, double-blind, placebo-controlled trial investigated Coramitug, a humanized monoclonal antibody, for transthyretin amyloid cardiomyopathy. Unlike existing therapies that primarily slow progression, Coramitug is designed to target misfolded transthyretin and promote clearance of existing amyloid deposits through antibody-mediated phagocytosis. The study randomized participants with transthyretin amyloid cardiomyopathy to evaluate its safety and effectiveness. This research aims to establish a therapeutic agent that could significantly improve patient outcomes by actively removing pathogenic protein aggregates. Article 4: High-Dose vs. Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: The FLUNITY-HD Prespecified Pooled Analysis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41212981 Summary: Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: The FLUNITY-HD Prespecified Pooled Analysis. This prespecified pooled analysis, FLUNITY-HD, aimed to clarify the effectiveness of high-dose inactivated influenza vaccine against specific cardiovascular outcomes in older adults. The study integrated data from two harmonized, individually randomized trials. While the high-dose vaccine has demonstrated superior protection against various hospitalization endpoints, its specific impact on cardiovascular events and in patients with existing cardiovascular disease needed further elucidation. This research sought to provide crucial evidence to guide influenza vaccination strategies for cardiovascular protection in this vulnerable population. Article 5: Cardiac Allograft Vasculopathy Inhibition with Alirocumab: The CAVIAR Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41212178 Summary: The CAVIAR Trial, an investigator-initiated, prospective, multicenter, double-blind, randomized study, investigated alirocum

Welcome to Cardiology Today – Recorded November 11, 2025. This episode summarizes 5 key cardiology studies on topics like congenital heart disease and transmitral mean pressure gradient. Key takeaway: Optimize Mitral Repair: Gradients & Regurgitation. Article Links: Article 1: Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents. (The New England journal of medicine) Article 2: Safety of Using Risk Stratification Along With High-Sensitivity Cardiac Troponin in the Emergency Department: A Secondary Analysis. (Journal of the American College of Cardiology) Article 3: Placental Malperfusion Is Associated With Adverse Outcomes in Congenital Heart Disease and With Genetic Variants in Placental Developmental Pathways. (Journal of the American College of Cardiology) Article 4: Using Transmitral Pressure Gradients and Residual Mitral Regurgitation to Optimize Outcome After Transcatheter Edge-to-Edge Repair. (Journal of the American College of Cardiology) Article 5: Computed Tomography Angiography or Standard Care After Left Main PCI? (Journal of the American College of Cardiology) Full episode page: https://podcast.explainheart.com/podcast/optimize-mitral-repair-gradients-regurgitation-11-11-25/ Featured Articles Article 1: Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211917 Summary: This multicenter, randomized, open-label, noninferiority trial in South Korea investigated non-vitamin K antagonist oral anticoagulant monotherapy compared to combination therapy. The study enrolled patients with atrial fibrillation who had received a drug-eluting stent at least one year prior. This research aims to provide crucial data to guide antithrombotic management after drug-eluting stent implantation in patients with atrial fibrillation, addressing current limitations in evidence-based guidelines. The primary objective is to determine if non-vitamin K antagonist oral anticoagulant monotherapy is noninferior to combination therapy for these specific patients. Article 2: Safety of Using Risk Stratification Along With High-Sensitivity Cardiac Troponin in the Emergency Department: A Secondary Analysis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41193094 Summary: This study conducted a secondary analysis to evaluate the effectiveness and safety of risk stratification using high-sensitivity cardiac troponin in the emergency department. While high-sensitivity cardiac troponin pathways are known to reduce length of stay and hospital admissions for myocardial infarction rule-out, this research aimed to confirm these benefits across low and intermediate risk patients. It also sought to ascertain if patients discharged were accurately identified as having a low risk of future cardiovascular events, thereby ensuring patient safety and appropriate resource utilization. Article 3: Placental Malperfusion Is Associated With Adverse Outcomes in Congenital Heart Disease and With Genetic Variants in Placental Developmental Pathways. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41193091 Summary: This study investigated the impact of placental malperfusion on outcomes in fetuses diagnosed with congenital heart disease. It aimed to determine if congenital heart disease fetuses with placental malperfusion experience adverse outcomes and exhibit genomic variations in shared vascular or placental developmental pathways. This research contributes to understanding the complex interplay between placental health and fetal cardiac development, potentially identifying novel risk factors and mechanisms. This foundational work could lead to improved risk stratification and targeted interventions for congenital heart disease. Article 4: Using Transmitral Pressure Gradients and Residual Mitral Regurgitation to Optimize Outcome After Transcatheter Edge-to-Edge Repair. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41193089 Summary: This study aimed to clarify the clinical significance of both mitral regurgitation reduction and transmitral mean pressure gradient elevation following mitral transcatheter edge-to-edge repair. Researchers evaluated 2360 patients with functional mitral regurgitation using post-discharge echocardiography. The objective was to understand the relationship between transmitral mean pressure gradient and patient outcomes, addressing a controversial area in post-procedural management. This research is crucial for optimizing procedural goals and improving patient selection to enhance long-term results after mitral transcatheter edge-to-edge repair. Article 5: Computed Tomography Angiography or Standard Care After Left Main PCI? Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40886174 Summary: En

Welcome to Cardiology Today – Recorded November 11, 2025. This episode summarizes 5 key cardiology studies on topics like triglycerides and antisense oligonucleotide. Key takeaway: CRISPR-Cas9 Gene Editing for Lipids. Article Links: Article 1: Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction. (The New England journal of medicine) Article 2: Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3. (The New England journal of medicine) Article 3: Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation. (The New England journal of medicine) Article 4: Evolocumab in Patients without a Previous Myocardial Infarction or Stroke. (The New England journal of medicine) Article 5: Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk. (The New England journal of medicine) Full episode page: https://podcast.explainheart.com/podcast/crispr-cas9-gene-editing-for-lipids-11-11-25/ Featured Articles Article 1: Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211954 Summary: This meta-analysis was conducted at the individual-patient level to clarify the benefit of beta-blockers following myocardial infarction in patients with a preserved left ventricular ejection fraction of at least 50 percent. Using data from five open-label trials, the research established a robust methodology to evaluate clinical outcomes. It specifically aimed to determine the impact of beta-blocker therapy versus no therapy on a primary composite endpoint, addressing a critical area of clinical uncertainty in this patient population. This study helps establish clinical guidance for beta-blocker use after myocardial infarction in patients without significantly reduced ejection fraction. Article 2: Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211945 Summary: This phase 1 ascending-dose trial was conducted to assess the safety and efficacy of CTX310, a lipid-nanoparticle-encapsulated clustered regularly interspaced short palindromic repeats-Cas9 endonuclease targeting ANGPTL3. The rationale for this gene-editing therapy is based on observed ANGPTL3 loss-of-function genetic variants, which are associated with decreased levels of low-density lipoprotein cholesterol and triglycerides, and a reduced lifetime risk of atherosclerotic cardiovascular disease. This study represents an important first step in investigating a novel gene-editing approach to lipid management, potentially offering a transformative therapeutic strategy for cardiovascular disease prevention. The research establishes foundational data for a promising new class of treatments aimed at modifying genetic risk factors. Article 3: Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211931 Summary: This international, open-label, randomized trial involving 1284 patients aimed to determine if successful catheter ablation for atrial fibrillation eliminates the need for long-term oral anticoagulant therapy. Patients had undergone successful ablation at least 1 year earlier and had a C.H.A.2.D.S.2.-V.A.S.c score of 1 or more, or 2 or more for women. The study employed a blinded-outcome-assessment design to rigorously compare antithrombotic strategies. This research is crucial for optimizing post-ablation care and could significantly reduce treatment burden for patients with atrial fibrillation. Article 4: Evolocumab in Patients without a Previous Myocardial Infarction or Stroke. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211925 Summary: This international, double-blind, randomized, placebo-controlled trial investigated the effect of the proprotein convertase subtilisin-kexin type 9 inhibitor evolocumab on major adverse cardiovascular events in patients without a previous myocardial infarction or stroke. While evolocumab is known to reduce major adverse cardiovascular events in patients with established atherosclerotic disease, this study expanded its evaluation to a primary prevention population with atherosclerosis. The research provides critical evidence regarding evolocumab’s potential to extend its cardiovascular benefits to patients who have not yet experienced a major cardiovascular event. This enhances understanding of evolocumab’s role in a broader spectrum of cardiovascular risk reduction. Article 5: Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211918 Summary: Two double-blind, randomized, placebo-controlled trials, CORE-T.I.M.I. 72a and CORE2-T.I.M.I. 72b, were conducted to establish the efficacy and

Welcome to Cardiology Today – Recorded November 10, 2025. This episode summarizes 5 key cardiology studies on topics like Coronary function testing and sodium-glucose cotransporter two inhibitors. Key takeaway: Aspirin Withdrawal Lowers LVAD Bleeding. Article Links: Article 1: Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial. (Circulation) Article 2: Withdrawal of aspirin in patients with left ventricular assist device treated with vitamin K antagonists: impact of anticoagulation quality in the randomized ARIES-HM3 trial. (European heart journal) Article 3: Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial. (European heart journal) Article 4: Coronary function testing vs angiography alone to guide treatment of angina with non-obstructive coronary arteries: the ILIAS ANOCA trial. (European heart journal) Article 5: Clonal Hematopoiesis and Incident Heart Failure. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/aspirin-withdrawal-lowers-lvad-bleeding-11-10-25/ Featured Articles Article 1: Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41206792 Summary: The DARE-AF Randomized Clinical Trial investigated the effect of dapagliflozin on preventing early atrial fibrillation recurrence following catheter ablation. This randomized study focused on patients without established indications for sodium-glucose cotransporter two inhibitors like diabetes, heart failure, or chronic kidney disease. The trial aimed to determine if dapagliflozin could reduce recurrence in this broader population, building on observational data suggesting such benefits in other patient groups. The research specifically explored a potential new therapeutic application for dapagliflozin in post-ablation atrial fibrillation management. Article 2: Withdrawal of aspirin in patients with left ventricular assist device treated with vitamin K antagonists: impact of anticoagulation quality in the randomized ARIES-HM3 trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41206679 Summary: The ARIES-HM3 trial demonstrated that aspirin can be safely omitted from the antithrombotic regimen for patients with a HeartMate three left ventricular assist device who are also receiving vitamin K antagonists. This randomized study found that withdrawing aspirin significantly reduced bleeding events without increasing thrombotic risks. The research also highlighted that high quality vitamin K antagonist management, assessed by Time in Therapeutic Range, is crucial for optimal outcomes. This advancement provides a simplified and safer antithrombotic strategy for advanced heart failure patients with left ventricular assist devices. Article 3: Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40796244 Summary: The A.S.P.R.E.E. trial conducted an extended follow-up to assess the long-term effects of low-dose aspirin on major adverse cardiovascular events and major hemorrhage in older adults. This research analyzed both in-trial data from 2010 to 2017 and post-trial data from 2017 to 2022. The study cohort included participants aged 70 years or older, or 65 years and older for U.S. minorities, focusing on primary prevention of atherosclerotic cardiovascular disease events. The extended follow-up aimed to provide crucial long-term evidence to inform clinical guidelines on aspirin use in this vulnerable population. Article 4: Coronary function testing vs angiography alone to guide treatment of angina with non-obstructive coronary arteries: the ILIAS ANOCA trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40796241 Summary: The I.L.I.A.S. A.N.O.C.A. trial investigated the feasibility, safety, and effectiveness of routine ad hoc invasive coronary function testing for diagnosing angina with non-obstructive coronary arteries. This study hypothesized that combining coronary function testing with a disease-specific treatment protocol would significantly improve quality of life compared to standard care. Invasive coronary function testing is known to identify coronary vasomotor disorders in up to 90 percent of patients with angina with non-obstructive coronary arteries. The research aimed to establish a comprehensive diagnostic and treatment pathway for this challenging patient population. Article 5: Clonal Hematopoiesis and Incident Heart Failure. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41206888 Summary: This study investigated the association between specific clonal hematopoiesis of indeterminate potential subtypes and incident heart failure, aim

Welcome to Cardiology Today – Recorded November 09, 2025. This episode summarizes 5 key cardiology studies on topics like voltage-gated sodium channel and heart failure. Key takeaway: S.G.L.T.2i Benefits Pre-Heart Failure in Older Adults. Article Links: Article 1: The effect of Sodium-dependent glucose transporter 2 Inhibitors on cardiac structural and functional indicators and biochemical markers in Older Adults with Hypertension and Pre-Heart Failure. (Cardiology) Article 2: FGF13 Regulates VGSC-Independent Cardiomyocyte Impulse Propagation via Cx43 Trafficking. (Circulation research) Article 3: The βIV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth. (Circulation research) Article 4: Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation. (Circulation research) Article 5: Vascular Niches Are the Primary Hotspots in Cardiac Aging. (Circulation research) Full episode page: https://podcast.explainheart.com/podcast/s-g-l-t-2i-benefits-pre-heart-failure-in-older-adults-11-09-25/ Featured Articles Article 1: The effect of Sodium-dependent glucose transporter 2 Inhibitors on cardiac structural and functional indicators and biochemical markers in Older Adults with Hypertension and Pre-Heart Failure. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41201974 Summary: This study investigated the impact of sodium-glucose cotransporter 2 inhibitors on cardiac structure and cardiorenal function in older adults with hypertension and pre-heart failure. Eighty-eight patients were randomized to receive dapagliflozin or conventional treatment. The research evaluated changes in N-terminal pro-brain natriuretic peptide, which is a key biomarker for heart failure, among other indicators. This study contributes to understanding the therapeutic potential of dapagliflozin in preventing heart failure progression in a vulnerable older population. Article 2: FGF13 Regulates VGSC-Independent Cardiomyocyte Impulse Propagation via Cx43 Trafficking. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41200819 Summary: This research explored the role of fibroblast growth factor homologous factor 13, known as F.G.F.13, in regulating cardiac conduction, specifically examining its influence on connexin 43 gap junctions independent of voltage-gated sodium channels. The study assessed cardiac conduction and cardiomyocyte action potentials in mice lacking F.G.F.13, revealing a novel mechanism by which F.G.F.13 impacts impulse propagation through connexin 43 trafficking. These findings establish a crucial, non-canonical pathway for arrhythmia development and provide a new target for antiarrhythmic strategies. Article 3: The βIV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41196954 Summary: This study investigated how the cytoskeletal protein beta-I.V.-spectrin, in complex with S.T.A.T.3, regulates the orientation of cardiac hypertrophic growth. Researchers evaluated this complex to understand its role in determining whether cardiac hypertrophy manifests as beneficial concentric or detrimental eccentric growth. The findings reveal a key mechanism influencing cardiac remodeling, which is crucial for distinguishing adaptive from maladaptive hypertrophy and potentially guiding future therapeutic interventions for heart failure. Article 4: Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41090220 Summary: This study examined mitochondrial calcium handling and cellular redox state in atrial fibrillation patients. Researchers isolated cardiac myocytes from patient-derived right atrial biopsies to subject them to workload transitions. The study revealed that atrial fibrillation is associated with impaired atrial mitochondrial calcium handling, identifying a potential new mechanistic target for understanding and treating this common arrhythmia. Article 5: Vascular Niches Are the Primary Hotspots in Cardiac Aging. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41090219 Summary: This research explored the microenvironmental changes within the heart that contribute to age-related cardiac dysfunction, fibrosis, and inflammation. By combining single-nucleus R.N.A. sequencing and spatial transcriptomics in aged mice hearts, the study identified vascular niches as primary hotspots for age-related alterations in cardiac tissue. These findings provide a detailed map of cellular and molecular changes in the aging heart, offering specific targets for interventions to mitigate cardiovascular aging. Transcript Today’s date is November 09, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. The effect of Sodium-dependent glucose transporter 2 Inhibitors on cardiac structural

Welcome to Cardiology Today – Recorded November 08, 2025. This episode summarizes 5 key cardiology studies on topics like n-3 polyunsaturated fatty acids and left ventricular mass. Key takeaway: Rivaroxaban Cuts S.T.E.M.I. Thrombus Burden. Article Links: Article 1: Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis. (The New England journal of medicine) Article 2: Sex differences in out-of-hospital cardiac arrest across age groups. (Heart (British Cardiac Society)) Article 3: Reduction of Thrombus Burden With Short-Term, Low-Dose Rivaroxaban Use in Acute Myocardial Infarction: The ARISE-ARMYDA 7 Randomized Trial. (Journal of the American Heart Association) Article 4: Prognostic Value of a Coronary Computed Tomography Angiography-Derived Ischemia Algorithm: Comparison Against Hybrid Coronary Computed Tomography Angiography/Positron Emission Tomography Imaging. (Journal of the American Heart Association) Article 5: Vessel-Specific Myocardial Mass in Patients With Stable Coronary Artery Disease. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/rivaroxaban-cuts-s-t-e-m-i-thrombus-burden-11-08-25/ Featured Articles Article 1: Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41201837 Summary: This double-blind randomized placebo-controlled trial investigated the efficacy of n-3 polyunsaturated fatty acid supplementation, including eicosapentaenoic acid and docosahexaenoic acid, for preventing cardiovascular events in patients undergoing hemodialysis. Cardiovascular disease is the leading cause of death in this population, and effective preventive therapies are currently limited. The study was conducted across 26 sites in Canada and Australia, aiming to address the uncertainty surrounding fish-oil supplementation benefits in this specific patient group. Its objective was to establish whether this intervention could provide cardiovascular protection. Article 2: Sex differences in out-of-hospital cardiac arrest across age groups. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41203298 Summary: This study aimed to comprehensively assess sex differences in out-of-hospital cardiac arrest, or O.H.C.A., across various age groups, a topic poorly explored in younger populations. Researchers analyzed all O.H.C.A. occurrences in Paris and its suburbs from May 2011 to December 2018. Primary outcomes investigated included sex-specific characteristics of O.H.C.A. and survival rates to hospital discharge within pediatric (28 days to 18 years), young adult (19 to 45 years), and older adult (over 45 years) age groups. This research sought to provide crucial data to better understand O.H.C.A. presentation and outcomes across the lifespan based on sex. Article 3: Reduction of Thrombus Burden With Short-Term, Low-Dose Rivaroxaban Use in Acute Myocardial Infarction: The ARISE-ARMYDA 7 Randomized Trial. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41195776 Summary: The A.R.I.S.E.-A.R.M.Y.D.A. 7 randomized trial investigated the efficacy of short-term, low-dose rivaroxaban when added to dual antiplatelet therapy in patients experiencing S.T.-segment-elevation myocardial infarction, or S.T.E.M.I. The study addressed the clinical challenge of managing large coronary thrombus burden, or L.C.T.B., in this high-risk population, where the optimal antithrombotic regimen for deferred stenting remains uncertain. This trial demonstrated that the addition of low-dose rivaroxaban effectively reduced thrombus burden. This finding provides a significant advance in optimizing antithrombotic strategies, potentially improving outcomes for S.T.E.M.I. patients with substantial coronary thrombus. Article 4: Prognostic Value of a Coronary Computed Tomography Angiography-Derived Ischemia Algorithm: Comparison Against Hybrid Coronary Computed Tomography Angiography/Positron Emission Tomography Imaging. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41195775 Summary: This observational cohort study evaluated the long-term prognostic value of an artificial intelligence-guided quantitative computed tomography ischemia, or A.I.-Q.C.T. ischemia, algorithm. This novel machine-learning method predicts myocardial ischemia directly from coronary computed tomography angiography, or C.C.T.A. The study aimed to compare A.I.-Q.C.T. ischemia against hybrid C.C.T.A. and positron emission tomography, or P.E.T., myocardial perfusion imaging in symptomatic patients with suspected coronary artery disease, or C.A.D. By establishing its prognostic utility relative to an established hybrid imaging technique, this research advances diagnostic capabilities for assessing ischemia and risk in C.A.D. Article 5: Vessel-Specific Myocardi

Welcome to Cardiology Today – Recorded November 07, 2025. This episode summarizes 5 key cardiology studies on topics like vascular endothelial function and adolescence. Key takeaway: Circadian Rhythm Attenuates O.S.A. Vascular Function. Article Links: Article 1: Triple Versus Dual Lipid-Lowering Therapy in Acute Coronary Syndrome: The ES-BempeDACS Randomized Clinical Trial. (Circulation) Article 2: Role of GLP-1 Receptor Agonists in Managing Cancer Therapy-Related Cardiac Dysfunction. (Journal of the American Heart Association) Article 3: Burden of Atherosclerosis and Outcomes of Acute Pulmonary Embolism: A Post Hoc Analysis of the Hokusai-VTE Trial. (Journal of the American Heart Association) Article 4: Adhering to Life’s Essential 8 Is Associated With Greater Bone Mineral Accrual During Childhood and Adolescence. (Journal of the American Heart Association) Article 5: Endogenous Circadian System Attenuates Nighttime Vascular Endothelial Function in People With Untreated Obstructive Sleep Apnea. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/circadian-rhythm-attenuates-o-s-a-vascular-function-11-07-25/ Featured Articles Article 1: Triple Versus Dual Lipid-Lowering Therapy in Acute Coronary Syndrome: The ES-BempeDACS Randomized Clinical Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41200807 Summary: The ES-BempeDACS Randomized Clinical Trial was designed to investigate the efficacy and safety of triple versus dual lipid-lowering therapy in patients with acute coronary syndrome. This study aimed to determine if combining bempedoic acid with high-intensity statins and ezetimibe could more effectively achieve low-density lipoprotein cholesterol goals. Current guidelines suggest a stepwise approach, but this trial explored an earlier intensive strategy from the onset of acute coronary syndrome. Its findings are anticipated to clarify optimal lipid-lowering strategies in this high-risk population. Article 2: Role of GLP-1 Receptor Agonists in Managing Cancer Therapy-Related Cardiac Dysfunction. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41195790 Summary: This retrospective cohort study utilized the TriNetX research network to explore the role of glucagon-like peptide-1 receptor agonists in managing cancer therapy-related cardiac dysfunction. The research focused on adults aged 18 years and older who had a history of cancer, received antineoplastic therapy, and subsequently developed this cardiac complication. While glucagon-like peptide-1 receptor agonists are known for their cardioprotective properties, their specific application in cancer therapy-related cardiac dysfunction had not been previously investigated. This study established a framework to analyze real-world data on this potential therapeutic strategy. Article 3: Burden of Atherosclerosis and Outcomes of Acute Pulmonary Embolism: A Post Hoc Analysis of the Hokusai-VTE Trial. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41195787 Summary: Trial. This post hoc analysis of the Hokusai-V.T.E. trial investigated the association between the burden of atherosclerosis and long-term clinical outcomes in patients experiencing acute pulmonary embolism. The study specifically assessed the presence and extent of atherosclerotic disease across multiple vascular territories, including coronary, cerebral, and peripheral, or in a single territory, or its absence. This research aimed to determine if the extent of atherosclerotic disease has prognostic implications for individuals affected by venous thromboembolism. Identifying these associations could improve risk stratification and guide management strategies for patients with acute pulmonary embolism. Article 4: Adhering to Life’s Essential 8 Is Associated With Greater Bone Mineral Accrual During Childhood and Adolescence. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41195786 Summary: This nationwide cross-sectional survey investigated the relationship between cardiovascular health and bone mineral accrual in 11468 Chinese children and adolescents aged 6 to 18 years. Cardiovascular health was assessed using the American Heart Association’s Life’s Essential 8 metrics, encompassing four behavioral metrics including diet and physical activity, and four factor metrics such as body mass index and blood pressure. The study found that adhering to Life’s Essential 8 was associated with greater bone mineral accrual during childhood and adolescence. This discovery highlights the critical importance of early cardiovascular health promotion for concurrently optimizing bone development and potentially reducing future osteoporosis risk. Article 5: Endogenous Circadian System Attenuates Nighttime Vascular Endothelial Function in People With Untreated Obstructive Sleep A

Welcome to Cardiology Today – Recorded November 07, 2025. This episode summarizes 5 key cardiology studies on topics like neutrophils and incident stroke. Key takeaway: Dapagliflozin Shields Kidneys from Acute Injury.. Article Links: Article 1: A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy. (The New England journal of medicine) Article 2: Advancing Assessment Methods for Human Cardiac Grafts During Normothermic Machine Perfusion. (Transplantation) Article 3: Adenosine-mediated Neutrophil Regulation by Dapagliflozin Attenuates Renal Ischemia/Reperfusion Injury: Real-time Imaging and Metabolic Insights. (Transplantation) Article 4: Cardiac resynchronisation therapy among adults with a systemic right ventricle: a multicentre experience. (Heart (British Cardiac Society)) Article 5: Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community-Dwelling Individuals. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/dapagliflozin-shields-kidneys-from-acute-injury-11-07-25/ Featured Articles Article 1: A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41196369 Summary: This Phase 3 trial investigated atacicept as a potential treatment for IgA nephropathy, a severe kidney disorder often leading to kidney failure or death in 50 percent of patients. Atacicept is a T.A.C.I.-Fc fusion protein designed to inhibit B-cell activating factor and a proliferation-inducing ligand, targeting the B-cell origin of the disease. This research establishes a crucial step in evaluating a specific immunomodulatory therapeutic approach for a condition affecting many patients with progressive kidney failure. The study explores a targeted strategy to improve outcomes in this prevalent primary glomerulopathy. Article 2: Advancing Assessment Methods for Human Cardiac Grafts During Normothermic Machine Perfusion. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41195985 Summary: This study focused on advancing assessment methods for human cardiac grafts during normothermic machine perfusion, addressing the critical challenge of donor heart scarcity in transplantation. Heart transplantation is the gold standard for end-stage heart failure, but only one-third of available donor hearts are currently utilized due to stringent selection criteria. By improving graft preservation and assessment through normothermic machine perfusion, this research aims to significantly increase the number of viable donor hearts. This advancement is crucial for expanding access to life-saving heart transplantation for millions affected by severe heart failure. Article 3: Adenosine-mediated Neutrophil Regulation by Dapagliflozin Attenuates Renal Ischemia/Reperfusion Injury: Real-time Imaging and Metabolic Insights. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41195983 Summary: This study investigated the renoprotective mechanisms of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, in attenuating acute kidney injury resulting from ischemia/reperfusion injury in nondiabetic mice. Researchers found that dapagliflozin achieved its protective effects through adenosine-mediated neutrophil regulation, a pathway further elucidated by concurrent treatment with an adenosine A2A receptor antagonist. This research provides crucial metabolic insights and demonstrates that dapagliflozin could offer a significant new therapeutic option for renal ischemia/reperfusion injury, even in nondiabetic patients. These findings expand the clinical utility of dapagliflozin beyond its current indications, addressing a major challenge with limited existing treatments. Article 4: Cardiac resynchronisation therapy among adults with a systemic right ventricle: a multicentre experience. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41198182 Summary: This international retrospective study from 33 centers aimed to clarify the benefits of cardiac resynchronization therapy in adults with congenital heart disease and a systemic right ventricle. While cardiac resynchronization therapy is a key treatment for heart failure in acquired heart disease, its efficacy in patients with a systemic right ventricle, such as those with transposition of the great arteries or congenitally corrected transposition of the great arteries, remains undefined. This research establishes a crucial multicenter experience to assess whether this therapy improves outcomes for this specific and challenging patient population. The study addresses an important knowledge gap to optimize treatment strategies for adults living with complex congenital heart conditions. Article 5: Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community-Dwelling Individuals. Journal: Journal of the American

Welcome to Cardiology Today – Recorded November 06, 2025. This episode summarizes 5 key cardiology studies on topics like emergency department and screening protocols. Key takeaway: Pregnancy Blood Pressure Variability Predicts Outcomes. Article Links: Article 1: Socioeconomic Status, Race, and Ethnicity in Management of Pediatric Supraventricular Tachycardia. (Journal of the American Heart Association) Article 2: Inflammation and Cognitive Decline: A Population-Based Cohort Study Among Aging Adults With Atrial Fibrillation. (Journal of the American Heart Association) Article 3: Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis. (Journal of the American Heart Association) Article 4: High Burden of Markedly Elevated Blood Pressure Among Adults Presenting to a Community Emergency Department: An Analytical Cross-Sectional Study at a Teaching Hospital in Missouri, USA. (Journal of the American Heart Association) Article 5: Blood Pressure Variability and Adverse Pregnancy and Cardiovascular Outcomes in the ALSPAC Cohort. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/pregnancy-blood-pressure-variability-predicts-outcomes-11-06-25/ Featured Articles Article 1: Socioeconomic Status, Race, and Ethnicity in Management of Pediatric Supraventricular Tachycardia. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41182008 Summary: This retrospective observational study investigated whether socioeconomic status, race, and ethnicity influence referral patterns for electrophysiology study and ablation in pediatric patients with supraventricular tachycardia or Wolff-Parkinson-White syndrome. It aimed to address the limited understanding of such inequities in pediatric arrhythmia management compared to adults. The research established a foundational understanding of how these social determinants may impact access to advanced care for children with these cardiac arrhythmias. This investigation is crucial for identifying potential disparities in healthcare delivery and developing strategies to ensure equitable management for all pediatric patients. Article 2: Inflammation and Cognitive Decline: A Population-Based Cohort Study Among Aging Adults With Atrial Fibrillation. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41182007 Summary: This population-based cohort study investigated the association between C-reactive protein levels and cognitive impairment and death in aging adults with atrial fibrillation. Researchers focused on individuals aged 45 years or older with prevalent atrial fibrillation but without existing cognitive impairment at baseline. The study explored the hypothesis that elevated C-reactive protein, a marker of inflammation, contributes to blood-brain barrier permeability, neuroinflammation, and subsequent neurodegeneration. By estimating these associations, the research provides a clearer understanding of potential inflammatory pathways linking atrial fibrillation to cognitive decline. Article 3: Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41182006 Summary: This drug target Mendelian randomization analysis explored whether genetically downregulated interleukin-6 signaling is associated with arteriolosclerotic cerebral small vessel disease, a leading cause of stroke and dementia. The study investigated the clinical, imaging, and pathological manifestations of this condition. By examining the genetic influence on interleukin-6, the research identifies a potential disease-modifying therapeutic target for arteriolosclerotic cerebral small vessel disease. This work advances the understanding of inflammatory pathways in neurovascular diseases, aiming to identify new treatment avenues where none currently exist. Article 4: High Burden of Markedly Elevated Blood Pressure Among Adults Presenting to a Community Emergency Department: An Analytical Cross-Sectional Study at a Teaching Hospital in Missouri, USA. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41182005 Summary: This analytical cross-sectional study investigated the prevalence and determinants of markedly elevated blood pressure, defined as 180 over 120 millimeters of mercury or higher, among adults presenting to a community emergency department. Researchers included adults aged 18 years or older at a Midwest teaching hospital over a one-year period from January 1 to December 31, 2024. The study aimed to address the limited data on this condition in United States community emergency departments. This research establishes foundational data on the burden of severe

Welcome to Cardiology Today – Recorded November 05, 2025. This episode summarizes 5 key cardiology studies on topics like computed tomography emphysema and population structure. Key takeaway: Aortic Stenosis: Leaflet-Specific Pathology Revealed. Article Links: Article 1: Impact of standardized team-based care on cardiogenic shock outcomes over time. (ESC heart failure) Article 2: SPIROMICS HF: Rationale, Design, and Reproducibility of Measures. (Circulation. Heart failure) Article 3: Clinical and Cardiovascular Magnetic Resonance Characteristics of Veteran Male Endurance Athletes With Atrial Fibrillation: VENTOUX-AF. (Journal of the American Heart Association) Article 4: Dual Contrast-Enhanced Microcomputed Tomography Uncovers Leaflet-Dependent Patterns of Macrocalcification, Fibrous Extracellular Matrix Remodeling, and Adipocyte Degeneration in Calcific Aortic Stenosis. (Journal of the American Heart Association) Article 5: Admixture Mapping of Lipid Traits in Hispanic Americans. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/aortic-stenosis-leaflet-specific-pathology-revealed-11-05-25/ Featured Articles Article 1: Impact of standardized team-based care on cardiogenic shock outcomes over time. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41189091 Summary: This study investigated the impact of implementing standardized team-based protocols on cardiogenic shock outcomes over time. Researchers analyzed 1453 consecutive patients from a single-center cardiogenic shock registry, comparing outcomes between two periods: 2017-2019 and 2020-2022. This methodology aimed to determine the influence of multidisciplinary management strategies on patient outcomes. The research establishes a crucial framework for evaluating the effectiveness of structured care approaches in this critical condition. Article 2: SPIROMICS HF: Rationale, Design, and Reproducibility of Measures. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41190426 Summary: HeF.pEF: Rationale, Design, and Reproducibility of Measures. The S.P.I.R.O.M.I.C.S. HeF.pEF study outlines its rationale and design for investigating the complex interplay between chronic obstructive pulmonary disease and Heart Failure with Preserved Ejection Fraction. This research specifically tests hypotheses linking new computed tomography emphysema subtypes with distinct cardiovascular phenotypes, including cor pulmonale and cor pulmonale parvus. The study also focuses on common airway branch variations and the reproducibility of its measures, establishing a robust framework for future discoveries. This work is crucial for identifying shared underlying mechanisms and improving management strategies for patients with these often coexisting conditions. Article 3: Clinical and Cardiovascular Magnetic Resonance Characteristics of Veteran Male Endurance Athletes With Atrial Fibrillation: VENTOUX-AF. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41182011 Summary: The V.E.N.T.O.U.X.-A.F. cross-sectional study investigated factors associated with atrial fibrillation in 39 veteran male endurance athletes, a population known for increased A.fib risk. Researchers aimed to determine if left atrial remodeling, assessed by cardiovascular magnetic resonance, exercise blood pressure, and bradyarrhythmia detected by implantable loop recorders, were linked to atrial fibrillation. This research provides a crucial methodological approach to unravel the unclear pathogenesis of atrial fibrillation in this unique athletic cohort. The findings will help inform targeted screening and preventive strategies for these individuals. Article 4: Dual Contrast-Enhanced Microcomputed Tomography Uncovers Leaflet-Dependent Patterns of Macrocalcification, Fibrous Extracellular Matrix Remodeling, and Adipocyte Degeneration in Calcific Aortic Stenosis. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41182010 Summary: This cross-sectional study utilized dual contrast-enhanced microcomputed tomography to uncover distinct leaflet-dependent patterns of macrocalcification, fibrous extracellular matrix remodeling, and adipocyte degeneration in calcific aortic stenosis. Researchers investigated 45 diseased and 39 control tricuspid aortic valve leaflets, providing detailed insights into the specific pathological variations between different leaflets. The study confirmed interleaflet differences, advancing the understanding of aortic valve disease progression beyond generalized observations. This detailed characterization offers crucial information for developing more precise diagnostic tools and targeted therapeutic strategies for calcific aortic stenosis. Article 5: Admixture Mapping of Lipid Traits in Hispanic Americans. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/4