Cardiology Today

Welcome to Cardiology Today – Recorded April 04, 2026. This episode summarizes 5 key cardiology studies on topics like arrhythmia vulnerability and catheter ablation. Key takeaway: Senolytics Prevent Atrial Arrhythmias in Elderly. Article Links: Article 1: Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation. (Heart rhythm) Article 2: Comparison of combined anatomic and functional modeling with purely anatomic assessment in scar-dependent ventricular tachycardia. (Heart rhythm) Article 3: Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits. (Heart rhythm) Article 4: Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study. (Heart rhythm) Article 5: Purkinje and septal substrate modification as a therapeutic option for patients with STEMI and refractory ventricular fibrillation. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/senolytics-prevent-atrial-arrhythmias-in-elderly-04-04-26/ Featured Articles Article 1: Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41519351 Summary: For patients undergoing repeat catheter ablation for atrial fibrillation (AF), a therapeutic approach involves either redo pulmonary vein isolation (PVI) alone or combining redo PVI with adjunctive posterior wall isolation (PWI). The use of pulsed-field ablation (PFA) is a significant consideration for achieving durable isolation in these procedures. This strategy directly addresses the clinical challenge of recurrent atrial fibrillation by targeting both pulmonary veins and the posterior wall. The comparison of these two ablation strategies provides insights into optimizing outcomes in repeat atrial fibrillation interventions. Article 2: Comparison of combined anatomic and functional modeling with purely anatomic assessment in scar-dependent ventricular tachycardia. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41513062 Summary: Identifying the critical substrate in scar-dependent ventricular tachycardia (VT) relies on precise mapping for ablation targets. Cardiac magnetic resonance imaging (M. R. I.) provides anatomic assessment (A. A.) to detect channels sustaining ventricular tachycardia. A refined approach involves heart digital twins, which integrate anatomic data with functional assessment for identifying the ventricular tachycardia isthmus. This combined anatomic and functional modeling offers a comprehensive method for characterizing the arrhythmogenic substrate compared to solely anatomic evaluations. Article 3: Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41513056 Summary: The study found that senolytic reduction of senescent cells effectively mitigated atrial arrhythmia vulnerability in aging rabbits. Cellular senescence contributes to age-related atrial fibrillation pathogenesis through its senescence-associated secretory phenotype, releasing proinflammatory and profibrotic factors. This research demonstrates a novel therapeutic strategy for age-related atrial arrhythmias by specifically targeting and reducing senescent cells. These findings indicate a direct link between cellular senescence and atrial fibrillation susceptibility in aging hearts. Article 4: Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41500490 Summary: Intrinsic antitachycardia pacing (iATP) represents a closed-loop algorithm capable of automatically designing and adjusting antitachycardia pacing therapy in real time. This technology effectively prevents defibrillator shocks and associated adverse outcomes, particularly in cases of rapid monomorphic ventricular tachycardia. Real-world performance data demonstrated the operational capability of iATP in a large, global patient cohort equipped with iATP-enabled implantable cardioverter-defibrillators. This confirms iATP’s role in enhancing arrhythmia management by dynamically tailoring therapy. Article 5: Purkinje and septal substrate modification as a therapeutic option for patients with STEMI and refractory ventricular fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41443487 Summary: The study described Purkinje and septal substrate modification using radiofrequency catheter ablation (R. F. C. A.) as a therapeutic option. This approach targets therapy-refractory ventricular fibrillation (V. F.) in patients after successful percutaneous coronary intervention (P. C. I.) for S. T.-el

Welcome to Cardiology Today – Recorded April 04, 2026. This episode summarizes 5 key cardiology studies on topics like Acetazolamide and Implantable Loop Recorders. Key takeaway: Bradyarrhythmias Reveal Stroke’s Atrial Link. Article Links: Article 1: Interhospital Transfer for Heart Failure in the United States: A Patient and Hospital-level Analysis from GWTG-HF. (Journal of cardiac failure) Article 2: Cardiac rehabilitation after transcatheter aortic valve implantation before, during and after the COVID-19 pandemic: a whole-population study. (Heart (British Cardiac Society)) Article 3: Acetazolamide Effects on Natriuresis and Diuresis in Acute Heart Failure Treated with Furosemide and SGLT2i (SANDI). (ESC heart failure) Article 4: Paced QRS Morphology and Lead Location in Left Bundle Branch Area Pacing Assessed by Photon-Counting Cardiac Computed Tomography. (Heart rhythm) Article 5: Prevalence of clinically significant bradyarrhythmias in patients implanted with loop recorders for cryptogenic stroke: A manifestation of atrial cardiomyopathy? (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/bradyarrhythmias-reveal-strokes-atrial-link-04-04-26/ Featured Articles Article 1: Interhospital Transfer for Heart Failure in the United States: A Patient and Hospital-level Analysis from GWTG-HF. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932644 Summary: This study characterized patients with Heart Failure who underwent interhospital transfer, establishing their demographic and clinical profiles. It found significant variations in the utilization of interhospital transfer among different hospitals across the United States. The data revealed distinctions in outcomes between transferred and non-transferred Heart Failure patients. This analysis provided foundational understanding of interhospital transfer patterns in this patient population. Article 2: Cardiac rehabilitation after transcatheter aortic valve implantation before, during and after the COVID-19 pandemic: a whole-population study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932822 Summary: This whole-population study established patterns of cardiac rehabilitation participation following Transcatheter Aortic Valve Implantation across England. It found variations in participation rates before, during, and after the C. O. V. I. D. minus 19 pandemic. The research demonstrated a specific association between cardiac rehabilitation participation and the primary outcome of unplanned all-cause rehospitalization. This analysis provided critical evidence regarding cardiac rehabilitation’s impact on clinical outcomes in this patient group. Article 3: Acetazolamide Effects on Natriuresis and Diuresis in Acute Heart Failure Treated with Furosemide and SGLT2i (SANDI). Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920937 Summary: The S. A. N. D. I. study investigated the natriuretic and diuretic effects of acetazolamide in patients with acute Heart Failure receiving intravenous furosemide and concomitant Sodium-Glucose Cotransporter-two Inhibitors. It found that acetazolamide provided significant natriuretic and diuretic benefits in this specific patient population, demonstrating enhanced decongestion. This research established the efficacy of adjunctive acetazolamide in acute Heart Failure patients who are also on Sodium-Glucose Cotransporter-two Inhibitors, addressing a previously unknown therapeutic gap. Article 4: Paced QRS Morphology and Lead Location in Left Bundle Branch Area Pacing Assessed by Photon-Counting Cardiac Computed Tomography. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932670 Summary: This study elucidated the relationship between intra-septal lead position in Left Bundle Branch Area Pacing and paced QRS morphology. It found that ultra-high-resolution Photon-Counting Computed Tomography precisely evaluated lead-tip location in 20 patients, differentiating between Left Bundle Branch Pacing, Left Ventricular Septal Pacing, and Deep Septal Pacing. The data established specific distances and spatial orientations of pacing leads within the septum, directly informing optimal lead placement strategies for physiological pacing. Article 5: Prevalence of clinically significant bradyarrhythmias in patients implanted with loop recorders for cryptogenic stroke: A manifestation of atrial cardiomyopathy? Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41519354 Summary: It found a notable burden of bradyarrhythmias in these patients compared with a matched control group. The data demonstrated that clinically significant bradyarrhythmias are a significant finding in this population, suggesting a potential manifestation of underlying atrial cardiomyopathy beyond Atrial Fibrillation detection. Transcript Today’s date is April 04, 2026. Welcome to Cardiology Today. Here are the

Welcome to Cardiology Today – Recorded April 03, 2026. This episode summarizes 5 key cardiology studies on topics like incident hypertension and quadruple guideline-directed medical therapies. Key takeaway: Glucagon-like Peptide-1 Agonists Cut Events Beyond Diabetes. Article Links: Article 1: Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity. (European heart journal) Article 2: Ten-minute asystolic warm ischemic time (AWIT) predicts mortality and severe primary graft dysfunction in donation after circulatory death hearts recovered with thoracoabdominal normothermic regional perfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction. (JAMA cardiology) Article 4: Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. (JAMA cardiology) Article 5: Effect of Sildenafil on Platelet Activation and Mediators of Vascular Remodeling During LVAD Support. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/glucagon-like-peptide-1-agonists-cut-events-beyond-diabetes-04-03-26/ Featured Articles Article 1: Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926331 Summary: Glucagon-like peptide-1 receptor agonists (G. L. P. minus 1 R. A.s) significantly reduced atherosclerosis burden and inflammatory biomarkers in experimental rabbit models. In clinical subjects, these agents decreased inflammatory biomarkers and major adverse cardiovascular events (MACE). These beneficial cardiovascular effects were observed irrespective of the patients’ glycemic status or obesity, indicating a direct cardiovascular protective mechanism. Article 2: Ten-minute asystolic warm ischemic time (AWIT) predicts mortality and severe primary graft dysfunction in donation after circulatory death hearts recovered with thoracoabdominal normothermic regional perfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40701206 Summary: A ten-minute asystolic warm ischemic time (A. W. I. T.) during donation after circulatory death (D. C. D.) heart recovery significantly predicted increased mortality in adult heart transplant recipients. This prolonged warm ischemic time was also associated with severe primary graft dysfunction. These findings specifically apply to cardiac allografts recovered using thoracoabdominal normothermic regional perfusion (N. R. P.). Article 3: Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920552 Summary: The study characterized the time to quadruple guideline-directed medical therapies (G. D. M. T.s) following an initial diagnosis of heart failure with reduced ejection fraction (H. F. rEF). It identified specific factors associated with achieving timely initiation of these therapies in a large cohort of patients. The findings provide contemporary estimates on the duration and facilitators of initiating optimal quadruple therapy for patients with H. F. rEF. Article 4: Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920533 Summary: The study found that genetic risk for high systolic blood pressure (S. B. P.) significantly stratified the risk of new-onset hypertension in women. This association was observed at two to seven years post partum. The genetic risk was an independent predictor, separate from women’s clinical characteristics and history of hypertensive disorders of pregnancy (H. D. P.), including preeclampsia, eclampsia, and gestational hypertension. Article 5: Effect of Sildenafil on Platelet Activation and Mediators of Vascular Remodeling During LVAD Support. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926705 Summary: V. A. D. Support. Observational studies revealed an association between phosphodiesterase-5 inhibitors, specifically sildenafil, and lower mortality and ischemic stroke in patients undergoing durable left ventricular assist device (L. V. A. D.) support. This study conducted a double-blind, randomized, placebo-controlled investigation into sildenafil’s causal effects on platelet activation and circulating mediators of vascular remodeling. This research aims to understand the direct physiological impact of sildenafil th

Welcome to Cardiology Today – Recorded April 02, 2026. This episode summarizes 5 key cardiology studies on topics like atrial fibrillation ablation and immature neutrophils. Key takeaway: Hypothermic Preservation Boosts Heart Transplant Survival. Article Links: Article 1: Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription. (European heart journal) Article 2: Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. (European heart journal) Article 3: Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Impact of HeartMate 3 left ventricular assist device infection on outcomes following heart transplant. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Improved 2-year heart transplant survival with moderate hypothermic donor heart preservation in the GUARDIAN heart registry. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/hypothermic-preservation-boosts-heart-transplant-survival-04-02-26/ Featured Articles Article 1: Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920862 Summary: The Swedish Heart Failure Registry enabled a detailed assessment of patient adherence and persistence to quadruple pharmacotherapy for heart failure with reduced ejection fraction. This assessment confirmed the critical importance of patient adherence for the real-world uptake of these treatments. The study found specific associations between medication adherence and subsequent patient morbidity and mortality outcomes. Article 2: Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914181 Summary: The E. M. B. O. L. minus A. F. Global Registry provided comprehensive data defining the incidence, outcomes, and procedural associations of stroke and systemic embolism following atrial fibrillation and left atrial flutter catheter ablation. This retrospective global registry captured detailed information from ablation centers worldwide, clarifying these previously poorly characterized complications. The registry’s findings illuminate critical insights into these post-ablation complications. Article 3: Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338428 Summary: This study found that immature neutrophils are elevated in human primary graft dysfunction. Researchers demonstrated a direct link between these immature neutrophils and granulocyte colony stimulating factor-driven injury in a murine model of lung ischemia-reperfusion. These findings indicate that immature neutrophils increase following lung transplantation and contribute to primary graft dysfunction severity. Article 4: Impact of HeartMate 3 left ventricular assist device infection on outcomes following heart transplant. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241030 Summary: This study found that infectious complications are common in patients implanted with HeartMate 3 left ventricular assist devices. The analysis specifically identified the impact of HeartMate 3 left ventricular assist device associated infection on outcomes following heart transplant. Researchers clarified crucial post-transplant outcomes by reviewing 115 patients with a HeartMate 3 device who underwent heart transplantation at Duke University Hospital. Article 5: Improved 2-year heart transplant survival with moderate hypothermic donor heart preservation in the GUARDIAN heart registry. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241029 Summary: Data from the G. U. A. R. D. I. A. N. Heart Registry demonstrated improved two year heart transplant survival when using moderate hypothermic donor heart preservation. The Paragonix SherpaPak Cardiac Transport System, a method of static preservation, showed superior outcomes c

Welcome to Cardiology Today – Recorded April 01, 2026. This episode summarizes 5 key cardiology studies on topics like estimated glomerular filtration rate and chronic kidney disease. Key takeaway: APOC3 Inhibition Cuts Lipids 70 Percent. Article Links: Article 1: Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. (Circulation) Article 2: Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study. (Circulation) Article 3: Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN STEMI Randomized Controlled Trial. (Circulation) Article 4: The Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Non-Inferiority Randomized Trial. (Circulation) Article 5: Pre-heart failure in early chronic kidney disease: clinical epidemiology and treatment. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/apoc3-inhibition-cuts-lipids-70-percent-04-01-26/ Featured Articles Article 1: Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41919388 Summary: Suboptimal cardiovascular-kidney-metabolic health is highly prevalent among older adults in the United States. The American Heart Association has developed a Cardiovascular-Kidney-Metabolic syndrome staging framework to categorize risk. Despite this framework, its predictive utility for incident heart failure remains an area of uncertainty in this population. Understanding the relationship between Cardiovascular-Kidney-Metabolic syndrome stages, echocardiographic characteristics, and heart failure risk is essential for clinical management. Article 2: Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910513 Summary: P. O. C. 3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-T. I. M. I. 73b Imaging Study. Olezarsen, an antisense oligonucleotide inhibiting apolipoprotein C-III, reduces triglycerides by approximately 60 percent and remnant cholesterol by approximately 70 percent. This treatment also decreases apolipoprotein B by approximately 15 percent, while maintaining a neutral effect on low-density lipoprotein cholesterol in patients with moderate hypertriglyceridemia. These observed lipid modifications suggest a therapeutic approach to address triglyceride-rich lipoproteins and remnant cholesterol. Such inhibition holds significant clinical interest for its potential impact on coronary atherosclerosis. Article 3: Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN STEMI Randomized Controlled Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910504 Summary: T.-Elevation Myocardial Infarction Undergoing Primary P. C. I.: H. E. P. A. R. I. N. S. T. E. M. I. Randomized Controlled Trial. Primary percutaneous coronary intervention is the preferred reperfusion strategy for patients with S. T.-elevation myocardial infarction. The benefits and safety of administering unfractionated heparin in the prehospital setting for these patients remain a critical clinical question. Optimizing pretreatment strategies with agents like unfractionated heparin at first medical contact is important for patients undergoing primary percutaneous coronary intervention. Investigating the efficacy and safety of such prehospital interventions informs best practices for acute myocardial infarction management. Article 4: The Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Non-Inferiority Randomized Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910411 Summary: The role of atrial pacing support in cardiac resynchronization therapy-defibrillator patients without sinus node dysfunction is a clinically relevant question. Simplified cardiac resynchronization therapy-defibrillator systems that offer atrial sensing without full pacing support via a two-lead system could reduce procedural complexity. Determining if a two-lead system is non-inferior to a conventional three-lead system is important for patient selection and device choice. Evaluating these systems helps optimize outcomes and minimize risks associated with device implantation for cardiac resynchronization therapy. Article 5: Pre-heart failure in early chronic kidney disease: clinical epidemiology and treatment. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914187 Summary: Chronic kidney disease affects 10 percent to 15 percent of adults globally and serves as a powerful, independent risk factor for cardiovascular diseases, including heart failure. Early stages of chronic kidney disease,

Welcome to Cardiology Today – Recorded April 01, 2026. This episode summarizes 5 key cardiology studies on topics like high-risk P. C. I. and mid-regional pro-adrenomedullin. Key takeaway: Adaptive A. I. Validates C. V. Event Adjudication. Article Links: Article 1: Angiography-Based Physiology to Guide Coronary Revascularization. (The New England journal of medicine) Article 2: Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention. (The New England journal of medicine) Article 3: IVUS or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The DKCRUSH VIII Randomized Clinical Trial. (Journal of the American College of Cardiology) Article 4: MR-ProADM Predicts Mortality and Heart Failure Events in ATTR Cardiac Amyloidosis. (Circulation) Article 5: Adaptive AI for Cardiovascular Event Adjudication: Cardiovascular Event Adjudication Across Different Definitions in the ODYSSEY OUTCOMES and EUCLID Trials. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/adaptive-a-i-validates-c-v-event-adjudication-04-01-26/ Featured Articles Article 1: Angiography-Based Physiology to Guide Coronary Revascularization. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910382 Summary: This international, randomized, noninferiority trial directly compared angiography-derived vessel fractional flow reserve (vFFR) with pressure-wire based fractional flow reserve (FFR) for guiding coronary revascularization. The trial evaluated vFFR, a method derived from three-dimensional quantitative coronary angiography that does not require a pressure wire or hyperemic agent. It established a robust head-to-head comparison to assess the effectiveness and safety of this less invasive physiological guidance for intermediate coronary lesions. The study addressed a critical lack of data on angiography-based revascularization guidance compared to the established pressure-wire FFR technique. Article 2: Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910380 Summary: This randomized trial assigned 300 patients with severe left ventricular dysfunction and extensive coronary artery disease to a strategy of elective unloading with a microaxial flow pump or to standard care during planned complex percutaneous coronary intervention (P. C. I.). The study established a direct comparison to determine if percutaneous left ventricular unloading improves outcomes in this high-risk patient population. It specifically investigated the impact of prophylactic mechanical support via a microaxial flow pump on mortality and complications during complex revascularization. This trial provides crucial data on the efficacy of a dedicated left ventricular unloading strategy in patients undergoing high-risk P. C. I. Article 3: IVUS or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The DKCRUSH VIII Randomized Clinical Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914946 Summary: V. U. S. or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The D. K. C. R. U. S. H. VIII Randomized Clinical Trial. Intravascular ultrasound (I. V. U. S.)-guided percutaneous coronary intervention (P. C. I.) is associated with fewer clinical events than angiography-guided P. C. I. The D. K. C. R. U. S. H. eight randomized clinical trial directly investigated the treatment effect of I. V. U. S.-guided P. C. I. compared to angiography-guided P. C. I. in patients with complex coronary bifurcation lesions undergoing double kissing crush stenting. This study established a head-to-head comparison to determine if I. V. U. S. guidance improves outcomes in this specific, challenging patient subgroup. It provides definitive evidence for the optimal guidance strategy in complex coronary bifurcation lesions treated with double kissing crush. Article 4: MR-ProADM Predicts Mortality and Heart Failure Events in ATTR Cardiac Amyloidosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914183 Summary: R. – ProA. D. M. Predicts Mortality and Heart Failure Events in A. T. T. R. Cardiac Amyloidosis. This study evaluated the prognostic value of 12 different circulating biomarkers for predicting outcomes in transthyretin amyloid cardiomyopathy (A. T. T. R. – C. M.). The assessed biomarkers included N-terminal pro-B-type natriuretic peptide (N. T. – proB. N. P.), high-sensitivity troponin I (hsTnI), and mid-regional pro-adrenomedullin (M. R. – proA. D. M.). The research specifically investigated tools for risk and prognosis stratification in A. T. T. R. – C. M. patients, addressing a growing clinical demand due to earlier diagnoses and new therapeutic options.

Welcome to Cardiology Today – Recorded March 31, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure and intermediate coronary lesions. Key takeaway: Mavacamten Targets Adolescent H. C. M.. Article Links: Article 1: IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease. (The New England journal of medicine) Article 2: Intravascular Ultrasound-Guided or Angiography-Guided Complex High-Risk PCI. (The New England journal of medicine) Article 3: Discontinuation of Beta-Blocker Therapy after Myocardial Infarction. (The New England journal of medicine) Article 4: Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy. (The New England journal of medicine) Article 5: Angiography-Derived Fractional Flow Reserve to Guide PCI. (The New England journal of medicine) Full episode page: https://podcast.explainheart.com/podcast/mavacamten-targets-adolescent-h-c-m-03-31-26/ Featured Articles Article 1: IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41911017 Summary: Percutaneous coronary intervention for unprotected left main coronary artery disease is a critical revascularization strategy in cardiology. The comparative effectiveness of intravascular ultrasonographic guidance versus conventional angiographic guidance in improving clinical outcomes for P. C. I. remains an area of active investigation. Clarifying the optimal guidance method holds significant implications for patient prognosis in this high-risk population. Article 2: Intravascular Ultrasound-Guided or Angiography-Guided Complex High-Risk PCI. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41911016 Summary: Intravascular ultrasonography guidance during percutaneous coronary intervention has been associated with increased stent optimization and reduced adverse events in patients with complex coronary artery lesions. Despite these recognized benefits and practice guideline recommendations for intracoronary imaging in anatomically complex lesions, adoption of this strategy in Western countries remains low. This highlights an ongoing need for robust evidence supporting its broader clinical integration in high-risk P. C. I. procedures. Article 3: Discontinuation of Beta-Blocker Therapy after Myocardial Infarction. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910427 Summary: The long-term role of beta-blocker therapy after a myocardial infarction is currently undefined for patients with preserved left ventricular systolic function and without heart failure, particularly in the era of modern reperfusion and secondary prevention. This clinical uncertainty impacts decisions regarding medication continuation for stable post-myocardial infarction patients. Resolving this question has substantial implications for reducing polypharmacy and tailoring post-event care. Article 4: Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910394 Summary: Approved pharmacologic therapies for pediatric hypertrophic cardiomyopathy are currently lacking, often leading to surgical intervention for left ventricular outflow tract obstruction. Mavacamten, a cardiac myosin inhibitor, is an established treatment for adults with obstructive hypertrophic cardiomyopathy. Evaluating the efficacy and safety of mavacamten in symptomatic adolescents with this condition addresses a critical unmet therapeutic need for younger patients. Article 5: Angiography-Derived Fractional Flow Reserve to Guide PCI. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910384 Summary: Physiological assessment of intermediate coronary lesions using an intracoronary pressure wire demonstrably improves clinical outcomes for patients undergoing cardiac catheterization and percutaneous coronary intervention. However, the widespread clinical adoption of pressure-wire-based physiological assessment remains limited. Angiography-derived fractional flow reserve shows good correlation with pressure-wire-based measurements and can simplify procedures, but its definitive impact on patient clinical outcomes remains unestablished. Transcript Today’s date is March 31, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease. Percutaneous coronary intervention for unprotected left main coronary artery disease is a critical revascularization strategy in cardiology. The comparative effectiveness of intravascular ultrasonographic guidance versus conventional angiographic guidance in improving clinical outcomes for P. C. I. remains an area of active investigation. Clarifyin

Welcome to Cardiology Today – Recorded March 30, 2026. This episode summarizes 5 key cardiology studies on topics like Cardiovascular Disease and Imaging. Key takeaway: AI Democratizes Congenital Heart Disease Echo. Article Links: Article 1: Sotatercept for Combined Post- and Pre-capillary Pulmonary Hypertension Associated With Heart Failure: Results from the Phase 2, Randomized, Placebo-Controlled CADENCE Study. (Circulation) Article 2: Multi-modality Imaging to Determine Underlying Causes of MINOCA in Women and Men. (Circulation) Article 3: Automated Echocardiographic Detection of Congenital Heart Disease Using Artificial Intelligence. (Circulation) Article 4: Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases. (European heart journal) Article 5: Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/ai-democratizes-congenital-heart-disease-echo-03-30-26/ Featured Articles Article 1: Sotatercept for Combined Post- and Pre-capillary Pulmonary Hypertension Associated With Heart Failure: Results from the Phase 2, Randomized, Placebo-Controlled CADENCE Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41904795 Summary: Combined post- and pre-capillary pulmonary hypertension associated with heart failure with preserved ejection fraction is a condition carrying significant mortality for which no proven therapies exist. The phase two randomized CADENCE study evaluated sotatercept as a potential treatment, administered at 0.3 or 0.7 milligrams per kilogram, or placebo, every three weeks. The primary endpoint measured was the change in pulmonary vascular resistance at week twenty-four. Article 2: Multi-modality Imaging to Determine Underlying Causes of MINOCA in Women and Men. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41903131 Summary: Myocardial infarction with non-obstructive coronary arteries presents with various underlying causes, often including mimicking conditions, despite imaging recommendations to identify etiologies. This international, prospective study characterized the mechanisms of myocardial infarction with non-obstructive coronary arteries, analyzed predictors of imaging abnormalities, and explored sex differences. Article 3: Automated Echocardiographic Detection of Congenital Heart Disease Using Artificial Intelligence. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41902792 Summary: Delayed or missed diagnosis of congenital heart disease significantly contributes to pediatric mortality worldwide. Expert echocardiography interpretation, which is central to diagnosing and triaging congenital heart disease, represents a scarce and maldistributed global resource. This study developed EchoFocus-C. H. D., an artificial intelligence-enabled tool designed to democratize diagnostics and extend expert-level interpretation beyond large academic centers. Article 4: Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41905344 Summary: Vigorous physical activity is known to provide greater health benefits per unit time than moderate activity, yet the full spectrum of these benefits across chronic diseases and the relative importance of intensity versus volume remains unclear. A prospective population-based cohort study of 96408 participants examined associations between the proportion of vigorous physical activity relative to total physical activity volume and the incidence of multiple chronic disease outcomes. Article 5: Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41903523 Summary: Elevated lipoprotein(a) levels are an established risk factor for atherosclerotic cardiovascular disease, however, its association with venous thromboembolism remains unclear, with potential modification by sex and hormonal status. This study investigated this relationship using participants from the U. K. Biobank with baseline lipoprotein(a) data. The study design excluded individuals with a history of venous thromboembolism or cancer, as well as those using anticoagulants. Transcript Today’s date is March 30, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Sotatercept for Combined Post- and Pre-capillary Pulmonary Hypertension Associated With Heart Failure: Results from the Phase 2, Randomized, Placebo-Controlled CADENCE Study. Combined post- and pre-capillary pulmonary hypertension associated with heart failure with preserved ejection fraction is a condition carrying significant mortality for which no proven therapies exist. The phase two randomized CADENCE study evaluated

Welcome to Cardiology Today – Recorded March 29, 2026. This episode summarizes 5 key cardiology studies on topics like Cardiomyopathy and Excess mortality. Key takeaway: Neurovascular Retinomics Predicts Heart Disease. Article Links: Article 1: Effect of age on 5-year excess mortality in heart failure with reduced ejection fraction. (European journal of heart failure) Article 2: Neurovascular retinomics for predicting heart diseases. (Cardiovascular research) Article 3: A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: effects on vascular function, sleep, and proteomic signatures in healthy adults. (Cardiovascular research) Article 4: Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice. (Cardiovascular research) Article 5: Cardiomyocyte-specific deficiency of C/EBPβ aggravates pressure overload-induced heart failure. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/neurovascular-retinomics-predicts-heart-disease-03-29-26/ Featured Articles Article 1: Effect of age on 5-year excess mortality in heart failure with reduced ejection fraction. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41889326 Summary: The abstract outlines a significant research study focused on the impact of age on 5-year excess mortality in Heart Failure with Reduced Ejection Fraction. This investigation includes patients aged 40 to 85 years, all presenting with a left ventricular ejection fraction of 40 percent or less, who underwent coronary angiography for suspected cardiomyopathy. The methodology involves matching patients by sex and age, thus characterizing a structured approach to understand age-related differences in survival outcomes. This research addresses a crucial gap in current understanding of age as a determinant of prognosis in Heart Failure with Reduced Ejection Fraction. Article 2: Neurovascular retinomics for predicting heart diseases. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41748319 Summary: The abstract describes a comprehensive methodology developed for utilizing neurovascular retinomics to predict incident heart diseases. This approach integrates multidimensional vascular parameters from color fundus photography with neural parameters obtained from optical coherence tomography. The study design incorporated LASSO regression for meticulous feature selection and employed a Gradient Boosting Machine model to assess predictive value. This framework characterizes a specific computational strategy for leveraging retinal imaging data in cardiovascular risk evaluation. Article 3: A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: effects on vascular function, sleep, and proteomic signatures in healthy adults. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41740584 Summary: The abstract presents a randomized, double-blind, crossover study that investigated the acute effects of low-level night-time road traffic noise on vascular function, sleep, and proteomic signatures in healthy adults. The research design exposed 74 healthy participants to three distinct overnight conditions, including a control with no noise and specific levels of road traffic noise. This structured methodology forms a basis for generating direct mechanistic evidence regarding environmental noise as a cardiovascular risk factor. The study provides a rigorous approach for evaluating acute physiological responses to noise exposure in humans. Article 4: Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41698873 Summary: The abstract highlights the emerging role of myo-inositol, which is consistently elevated in plasma of patients with Heart Failure, as a significant area of research in cardiac dysfunction. It details the function of sodium-myo-inositol co-transporter-1, or S. M. I. T. 1., a member of the sodium-glucose co-transporter family specifically expressed in the heart, in myo-inositol transport. The research described addresses the poorly understood mechanism by which myo-inositol dysregulation contributes to cardiac dysfunction. This investigation focuses on understanding the molecular pathways involving S. M. I. T. 1. in the context of heart failure. Article 5: Cardiomyocyte-specific deficiency of C/EBPβ aggravates pressure overload-induced heart failure. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41618689 Summary: The abstract introduces CCAAT/enhancer-binding protein beta, a transcription factor known for regulating cell processes including inflammation, as a significant area of cardiac research. It identifies a critical gap in understanding the cell-type-specifi

Welcome to Cardiology Today – Recorded March 28, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure and prognosis. Key takeaway: CAD Phenotypes Found for Tailored Prevention. Article Links: Article 1: Drivers of 1-year mortality decline after acute myocardial infarction in England and Wales: a 15-year national cohort study. (Heart (British Cardiac Society)) Article 2: Identifying clinical phenotype clusters in patients with coronary artery disease. (Heart (British Cardiac Society)) Article 3: Optimizing NT-proBNP Inclusion Cut-offs for Randomized Clinical Trials in Heart Failure: Data from the Swedish Heart Failure Registry. (ESC heart failure) Article 4: Role of Provocation and Exercise Imaging for the Identification of Candidates for Cardiac Myosin Inhibitors. (ESC heart failure) Article 5: Sex- and Phenotype-Specific Prognostic Implications of Body Mass Index in Acute Heart Failure. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/cad-phenotypes-found-for-tailored-prevention-03-28-26/ Featured Articles Article 1: Drivers of 1-year mortality decline after acute myocardial infarction in England and Wales: a 15-year national cohort study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40691042 Summary: A national cohort study of 852914 adult patients in England and Wales found that one-year all-cause mortality following acute myocardial infarction declined between 2005 and 2019. Researchers analyzed this 15-year dataset to quantify the contributions of clinical, treatment, and demographic factors to these changes. The findings provide crucial data for informing clinical strategies and health policy. Article 2: Identifying clinical phenotype clusters in patients with coronary artery disease. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40451277 Summary: This study found that clinical phenotype clusters exist in patients with coronary artery disease. Researchers used unsupervised machine learning through latent class analysis to identify these clusters. The study assessed the relationship of these identified phenotypes with the risk of recurrent cardiovascular events. This work addresses the need for specific considerations beyond current one-size-fits-all guideline recommendations for cardiovascular event prevention. Article 3: Optimizing NT-proBNP Inclusion Cut-offs for Randomized Clinical Trials in Heart Failure: Data from the Swedish Heart Failure Registry. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41894572 Summary: This study provided evidence-based guidance on selecting optimal N-terminal pro-B-type natriuretic peptide cut-offs for randomized controlled trials in heart failure. Researchers utilized data from the Swedish Heart Failure Registry, applying N-terminal pro-B-type natriuretic peptide cut-offs ranging from 200 to 5000 picograms per milliliter, which were derived from prior randomized controlled trials. The study calculated one-year incidence proportions to optimize the balance between event enrichment and screening failure across various heart failure subgroups. This optimizes patient selection for clinical trials, improving efficiency and relevance. Article 4: Role of Provocation and Exercise Imaging for the Identification of Candidates for Cardiac Myosin Inhibitors. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885188 Summary: This study compared the characteristics and therapeutic response of patients with obstructive hypertrophic cardiomyopathy who only showed treatment-qualifying left ventricular outflow tract obstruction during exercise echocardiography, versus those who met eligibility at rest. Researchers assessed the therapeutic response to cardiac myosin inhibitors, specifically mavacamten, in these patient groups. The findings clarify the clinical profile and treatment response of patients who require exercise imaging to establish eligibility for these inhibitors. This work helps identify appropriate candidates for mavacamten therapy. Article 5: Sex- and Phenotype-Specific Prognostic Implications of Body Mass Index in Acute Heart Failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885184 Summary: This study found that the prognostic implications of body mass index in patients with acute heart failure differed according to heart failure phenotype and sex. Researchers analyzed 5271 patients hospitalized for acute heart failure from the Korean Heart Failure three Registry. Body mass index was categorized into low, normal, and high groups using Asia-Pacific criteria. The primary outcome was a composite of two-year all-cause mortality or heart transplantation, showing varying risks across subgroups. Transcript Today’s date is March 28, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Drivers of 1-year mortalit

Welcome to Cardiology Today – Recorded March 28, 2026. This episode summarizes 5 key cardiology studies on topics like oral anticoagulation and caregiver self-care. Key takeaway: Oral Semaglutide Cuts CV Events 14% in Type 2 Diabetes. Article Links: Article 1: Supporting Family Caregiver Health in Heart Failure: Longitudinal Associations Between Heart Failure Caregiver Self-Care and Patient Hospitalizations. (Journal of cardiac failure) Article 2: Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial. (JAMA cardiology) Article 3: Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial. (JAMA cardiology) Article 4: Prevalence and characteristics of patients with coronary heart disease and blood pressure below target: the INTERASPIRE study. (Heart (British Cardiac Society)) Article 5: Aortic coarctation and long-term morbidity after arterial switch operation: a multicentre international cohort study. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/oral-semaglutide-cuts-cv-events-14-in-type-2-diabetes-03-28-26/ Featured Articles Article 1: Supporting Family Caregiver Health in Heart Failure: Longitudinal Associations Between Heart Failure Caregiver Self-Care and Patient Hospitalizations. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895678 Summary: Prior research demonstrated that health coaching reduces heart failure caregiver stress and improves caregiver self-care behaviors. This randomized controlled trial assessed the longitudinal associations between improved caregiver self-care and heart failure patient hospitalization outcomes. The study identified how changes in caregiver well-being influenced patient clinical trajectories, underscoring the critical role of caregiver support in patient health. Article 2: Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879791 Summary: The S. O. U. L. randomized clinical trial found that once-daily oral semaglutide reduced the risk of major adverse cardiovascular events by 14 percent compared to placebo. This significant benefit occurred in individuals with type two diabetes and atherosclerotic cardiovascular disease or chronic kidney disease receiving standard of care. This secondary analysis demonstrated the specific changes oral semaglutide induced in long-term cardiovascular risk factors within this high-risk patient group. Article 3: Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879767 Summary: Left atrial appendage occlusion is a critical intervention for patients with contraindications to oral anticoagulation and an increased risk of major bleeding. The Amulet I. D. E. randomized clinical trial meticulously identified the incidence, key predictors, and effective management strategies for major bleeding following left atrial appendage occlusion. This study, involving 1878 randomized patients comparing the Amulet with the Watchman devices, also determined the clinical impact of these bleeding events on patient outcomes. Article 4: Prevalence and characteristics of patients with coronary heart disease and blood pressure below target: the INTERASPIRE study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41887758 Summary: Many patients with coronary heart disease exhibit blood pressure above guideline targets, even with ongoing treatment. European guidelines offer conflicting recommendations regarding patients with on-treatment blood pressure below target, with the 2023 European Society of Hypertension guidelines issuing a class three recommendation to proactively avoid blood pressure below target. The I. N. T. E. R. A. S. P. I. R. E. study established the prevalence and characteristics of patients with coronary heart disease whose blood pressure fell below target levels. Article 5: Aortic coarctation and long-term morbidity after arterial switch operation: a multicentre international cohort study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40701798 Summary: Cardiovascular interventions and complications commonly occur after arterial switch operation in patients with dextro-transposition of the great arteries. While complex anatomy, such as ventricular septal defects, is often associated with these outcomes, the independent role of aortic coarctation remained unclear. This multicenter international cohort study analyzed 502 adults from the E. P. O

Welcome to Cardiology Today – Recorded March 28, 2026. This episode summarizes 5 key cardiology studies on topics like microvascular resistance and immunosuppressive therapy. Key takeaway: Ghost Approval: Transplant Drug Access. Article Links: Article 1: Tricuspid regurgitation: standardized stepwise work-up from referral to expert heart valve centre. (European heart journal) Article 2: Atrial fibrillation density as a biomarker for ischaemic stroke risk prediction. (European heart journal) Article 3: Coronary autoregulation: the complex interplay between epicardial and microvascular resistance. (European heart journal) Article 4: Diuretic Resistance Risk and the Efficacy of Natriuresis-Guided Diuretic Therapy in Acute Heart Failure: Post Hoc Analysis From the PUSH-AHF Trial. (JACC. Heart failure) Article 5: When Coverage Is Not Access: A Heart Transplant Recipient’s Perspective on Everolimus, FDA Labeling, and the Problem of “Ghost Approval”. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/ghost-approval-transplant-drug-access-03-28-26/ Featured Articles Article 1: Tricuspid regurgitation: standardized stepwise work-up from referral to expert heart valve centre. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895721 Summary: A standardized stepwise work-up for Tricuspid Regurgitation was described, guiding patients from referral to an expert heart valve center. Optimal therapy selection for Tricuspid Regurgitation requires an integrated and systematic approach. This approach considers the condition’s etiology, disease stage, comorbidities, operative risk, and anatomical feasibility. Recent advances in surgical and transcatheter interventions have renewed focus on Tricuspid Regurgitation, a common condition historically associated with poor outcomes. Article 2: Atrial fibrillation density as a biomarker for ischaemic stroke risk prediction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895321 Summary: This study evaluated the association between Atrial Fibrillation density and ischaemic stroke, investigating whether this temporal episode distribution improves risk stratification compared to Atrial Fibrillation burden. The research utilized data from two U.S. cohorts of patients with cardiac implantable electronic devices that were remotely monitored by the Veterans Health Administration. Atrial Fibrillation density was considered as a potentially more clinically relevant and prognostically important biomarker than traditional classifications based on episode duration or cumulative burden. Article 3: Coronary autoregulation: the complex interplay between epicardial and microvascular resistance. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895317 Summary: Coronary autoregulation maintains stable blood flow in the coronary circulation despite fluctuations in myocardial perfusion pressure, provided metabolic demands remain constant. The dynamic modulation of microvascular resistance within the coronary microcirculation determines coronary blood flow and is central to this regulatory process. This intrinsic mechanism enables the coronary vasculature to adapt to variations in aortic pressure and epicardial resistance. Article 4: Diuretic Resistance Risk and the Efficacy of Natriuresis-Guided Diuretic Therapy in Acute Heart Failure: Post Hoc Analysis From the PUSH-AHF Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41893376 Summary: A post hoc analysis from the P. U. S. H. hyphen A. H. F. trial evaluated the efficacy of natriuresis-guided diuretic therapy in patients with acute decompensated heart failure at risk of diuretic resistance. Diuretic resistance is common in acute decompensated heart failure and is associated with residual congestion and poor prognosis. The study identified diuretic resistance risk using the B. A. N. hyphen A. D. H. F. score, which incorporates blood urea nitrogen, creatinine, natriuretic peptide levels, atrial fibrillation, diastolic blood pressure, hypertension, and home diuretics. Article 5: When Coverage Is Not Access: A Heart Transplant Recipient’s Perspective on Everolimus, FDA Labeling, and the Problem of “Ghost Approval”. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895624 Summary: This perspective piece introduced the concept of “ghost approval,” where a technically approved medication remains financially or logistically inaccessible to the patient. It highlights that access to immunosuppressive therapy is essential for long-term survival in heart transplant recipients. A first-person experience with everolimus, an M. T.

Welcome to Cardiology Today – Recorded March 27, 2026. This episode summarizes 5 key cardiology studies on topics like pericarditis and cardiometabolic dysfunction. Key takeaway: Socioeconomic Status Drives Heart Failure Risk. Article Links: Article 1: Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology. (European heart journal) Article 2: Sex differences in cardiovascular-kidney-metabolic syndrome: the FINE-HEART pooled analysis. (European heart journal) Article 3: Cardiac involvement in parasitic infections. (European heart journal) Article 4: Inflammatory pathways in atrial fibrillation: mechanisms and novel therapeutic targets. (European heart journal) Article 5: Socioeconomic Correlates of Incident Heart Failure and Consequent Mortality: The All of Us Program. (JACC. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/socioeconomic-status-drives-heart-failure-risk-03-27-26/ Featured Articles Article 1: Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885139 Summary: The field of reverse cardio-oncology found that subclinical and overt cardiometabolic dysfunction, specifically obesity, fuels breast cancer risk and alters tumor biology. This occurs through shared mechanisms including chronic inflammation, hormonal dysregulation, and cellular senescence. Refined obesity phenotypes, such as metabolically healthy versus unhealthy obesity and sarcopenic obesity, demonstrate more accurate stratification of breast cancer risk compared to body mass index alone. This paradigm highlights specific biological links between cardiovascular and oncological diseases. Article 2: Sex differences in cardiovascular-kidney-metabolic syndrome: the FINE-HEART pooled analysis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41884984 Summary: This prespecified analysis, drawing from two trials on chronic kidney disease and type two diabetes (FIDELIO-DKD and FIGARO-DKD) and one trial on heart failure (FINEARTS-HF), specifically investigated sex differences in cardiovascular-kidney-metabolic syndrome. The analysis consolidated individual participant data to clarify how cardiometabolic risk factors, and their impact, manifest differently between women and men. It provided a comprehensive platform to understand these distinctions in populations with chronic kidney disease, type two diabetes, and heart failure with mildly reduced or preserved ejection fraction. The study’s rigorous data pooling addressed a critical knowledge gap regarding sex-specific outcomes in cardiovascular-kidney-metabolic syndrome. Article 3: Cardiac involvement in parasitic infections. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879141 Summary: Parasitic infections are identified as an important, yet underrecognized, cause of cardiovascular disease, especially in endemic regions and increasingly due to global migration and travel. Cardiac involvement results from either direct parasitic invasion or, more commonly, from immune-mediated and inflammatory mechanisms. These processes primarily affect the myocardium and pericardium, leading to clinical manifestations such as acute myocarditis, dilated or restrictive cardiomyopathy, and pericarditis. This highlights the diverse pathological pathways by which parasites impact cardiac health. Article 4: Inflammatory pathways in atrial fibrillation: mechanisms and novel therapeutic targets. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879137 Summary: Inflammation is definitively identified as a predisposing factor for atrial fibrillation, the most common sustained cardiac arrhythmia. Systemic inflammatory disorders, including autoimmune disorder, diabetes mellitus, and obesity, as well as local inflammation of the heart or pericardium, are directly linked to atrial fibrillation. Inflammation triggers various signaling pathways and directly influences proinflammatory cytokines, which subsequently promote structural and electrical changes in the atria. These mechanisms underscore the critical role of inflammatory processes in atrial fibrillation pathogenesis. Article 5: Socioeconomic Correlates of Incident Heart Failure and Consequent Mortality: The All of Us Program. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885671 Summary: This study identified prospective associations between socioeconomic status and incident heart failure in adults without pre-existing heart failure. It also demonstrated associations between socioeconomic status and all-cause mortality in patients already diagnosed with heart failure. The analysis utilized data from the National Institutes of Health-run All of Us Research Program. This research provides crucial evidence that both individual and neighborhood measures of socioeconomic status independ

Welcome to Cardiology Today – Recorded March 26, 2026. This episode summarizes 5 key cardiology studies on topics like conservative care and symptom management. Key takeaway: Early Surgery Reduces Aortic Stenosis Mortality. Article Links: Article 1: Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years. (The New England journal of medicine) Article 2: Renin-Aldosterone Profiles and Cardiorenal Outcomes in Hypertension: A Nationwide Cohort Study. (Journal of the American College of Cardiology) Article 3: Palliative care in cardiovascular medicine. (European heart journal) Article 4: Cardiovascular disease in China: epidemiological evolution and implications. (European heart journal) Article 5: Wearable devices and cardiovascular health: revolutionizing remote monitoring and disease prevention. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/early-surgery-reduces-aortic-stenosis-mortality-03-26-26/ Featured Articles Article 1: Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41880613 Summary: Among asymptomatic patients with severe aortic stenosis, early surgery significantly lowered the risk of operative mortality or death from cardiovascular causes compared to conservative care. This means patients who received early surgery had a reduced composite rate of death during surgery or within 30 days after surgery. The data demonstrated this significant reduction in operative and cardiovascular mortality with early surgical intervention. These findings provided a clear benefit for early surgery in this specific patient population. Article 2: Renin-Aldosterone Profiles and Cardiorenal Outcomes in Hypertension: A Nationwide Cohort Study. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879574 Summary: Renin-independent aldosterone production contributes to adverse cardiorenal outcomes. The study established a definitive association between specific renin-aldosterone profiles and the occurrence of cardiorenal events in adults with hypertension. These findings provide population-based evidence demonstrating the significant role of distinct aldosterone production mechanisms in influencing cardiorenal health in hypertensive patients. The comprehensive analysis identified key patterns linking renin-aldosterone levels to adverse cardiovascular and renal outcomes. Article 3: Palliative care in cardiovascular medicine. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879158 Summary: Palliative care for adults with advanced cardiovascular disease consistently improves patients’ quality of life. It effectively supports caregivers and successfully aligns treatments with patient values and goals. The implementation of palliative care encompasses essential elements such as comprehensive symptom management, proactive advanced care planning, and patient-centered shared decision-making processes. These core components consistently lead to better patient experiences and outcomes in advanced cardiovascular disease. Article 4: Cardiovascular disease in China: epidemiological evolution and implications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879157 Summary: Cardiovascular disease remains the predominant cause of mortality in China, having undergone significant epidemiological transitions over several decades. This comprehensive review synthesized extensive observational data, revealing key features of cardiovascular disease’s evolving epidemiology across various dimensions within the country. The findings definitively establish crucial trends and interrelationships in cardiovascular disease incidence and prevalence among the Chinese population. This analysis demonstrates how the disease burden has shifted and provides a foundational understanding of its current state in China. Article 5: Wearable devices and cardiovascular health: revolutionizing remote monitoring and disease prevention. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879156 Summary: Wearable devices are transforming cardiovascular medicine, as they enable continuous remote monitoring of physiological and behavioral measures outside traditional clinical settings. Smartwatches and activity trackers effectively utilize motion and biometric sensors to accurately measure physical activity, sleep quality, heart rate, and rhythm. These devices successfully empower patients to assume a more active role in their health by converting health goals into objective, quantifiable measures. This technological advancement directly contributes to revolutionizing remote monitoring and disease prevention in cardiovascular health. Transcript Today’s date is March 26, 2026. Welcome to Cardiology Today. Here are the latest research finding

Welcome to Cardiology Today – Recorded March 25, 2026. This episode summarizes 5 key cardiology studies on topics like healthcare costs and heart failure. Key takeaway: LVAD Reverses Heart Failure, Avoids Transplant. Article Links: Article 1: Recovery From Heart Failure: Microvascular Mechanisms. (Circulation) Article 2: The Fontan Outcomes Network: Findings After 2 Years and 1121 Participants. (Circulation) Article 3: Association Between Copayments and Attendance in Cardiac Rehabilitation: A Nationwide Analysis From the AACVPR Registry. (Journal of the American Heart Association) Article 4: Sociodemographic and Clinical Predictors of Mortality in Adults With Congenital Heart Disease. (Journal of the American Heart Association) Article 5: Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/lvad-reverses-heart-failure-avoids-transplant-03-25-26/ Featured Articles Article 1: Recovery From Heart Failure: Microvascular Mechanisms. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878819 Summary: Left ventricular assist device support improves cardiac histology and function in patients with heart failure. This improvement sometimes allows patients to avoid heart transplantation after Left Ventricular Assist Device removal. The study investigated the microvascular and cellular programs underlying this observed myocardial recovery. Article 2: The Fontan Outcomes Network: Findings After 2 Years and 1121 Participants. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878814 Summary: Survival after Fontan palliation for single ventricle heart disease has substantially improved. The Fontan Outcomes Network, comprising 38 congenital heart centers, was established to define the long-term trajectory of these patients. The network successfully enrolled 1121 participants within its first two years, providing a substantial cohort for future longitudinal analysis. Article 3: Association Between Copayments and Attendance in Cardiac Rehabilitation: A Nationwide Analysis From the AACVPR Registry. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878870 Summary: A. C. V. P. R. Registry. Improving cardiac rehabilitation participation remains a national priority. This study utilized the American Association of Cardiovascular and Pulmonary Rehabilitation registry, analyzing data from 2012 to 2021. The investigation explored the relationship between patient copayments and attendance in cardiac rehabilitation programs, and also patient dropout rates. This analysis addressed the crucial clinical question of how financial barriers impact patient adherence and program completion. Article 4: Sociodemographic and Clinical Predictors of Mortality in Adults With Congenital Heart Disease. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878868 Summary: Mortality in adults with congenital heart disease is strongly driven by disease complexity. This study investigated the influence of both clinical factors and social determinants of health on all-cause mortality in patients with adult congenital heart disease. Researchers utilized a single-center retrospective cohort from the Mayo Adult Congenital Heart Disease Registry, spanning from 2004 to 2017. The findings contributed to understanding critical factors impacting long-term survival in this complex patient population. Article 5: Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878867 Summary: Sleep behaviors influence the development of both chronic obstructive pulmonary disease and coronary heart disease. This study explored the associations of specific sleep patterns with dynamic transitions of these conditions. The investigation also addressed the interaction of sleep patterns with genetic susceptibility and the mediating role of inflammatory biomarkers and metabolites. The analysis utilized extensive data from the U. K. Biobank to characterize these complex interrelationships affecting comorbidity. Transcript Today’s date is March 25, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Recovery From Heart Failure: Microvascular Mechanisms. Left ventricular assist device support improves cardiac histology and function in patients with heart failure. This improvement sometimes allows patients to avoid heart transplantation after Left Ventricular Assist Device removal. The s

Welcome to Cardiology Today – Recorded March 25, 2026. This episode summarizes 5 key cardiology studies on topics like P. P. A. R. minus alpha and left ventricular strain. Key takeaway: METTL14 Inhibits Atherogenesis. Article Links: Article 1: Parsimonious echocardiography-based model for predicting long-term all-cause mortality in heart failure with preserved ejection fraction. (Heart (British Cardiac Society)) Article 2: Atorvastatin and left ventricular strain during anthracycline-based chemotherapy. (International journal of cardiology) Article 3: The inflammation-microvascular axis in prognosis: Integrated FAI and AMR assessment for risk stratification after PCI in NSTEMI patients. (International journal of cardiology) Article 4: METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs. (Cardiovascular research) Article 5: THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. (Hypertension (Dallas, Tex. : 1979)) Full episode page: https://podcast.explainheart.com/podcast/mettl14-inhibits-atherogenesis-03-25-26/ Featured Articles Article 1: Parsimonious echocardiography-based model for predicting long-term all-cause mortality in heart failure with preserved ejection fraction. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41876216 Summary: Existing Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide, Functional testing, Final Aetiology (H. F. A. minus P. E. F. F.) and Heavy, Hypertensive, Atrial Fibrillation, Pulmonary Hypertension, Elder, Filling Pressure (H. Two F. P. E. F.) scores do not adequately stratify long-term all-cause mortality risk in Heart Failure with Preserved Ejection Fraction (H. F. pEF) patients. To address this identified clinical gap, researchers developed and internally validated a parsimonious echocardiography-based model. This new model was designed to provide improved prediction of long-term all-cause mortality in the H. F. pEF patient population. Article 2: Atorvastatin and left ventricular strain during anthracycline-based chemotherapy. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41875954 Summary: Anthracyclines are associated with impaired Left Ventricular (L. V.) deformation, as measured by global longitudinal strain (G. L. S.) and global circumferential strain (G. C. S.). The S. T. O. P. minus C. A. trial investigated whether atorvastatin attenuates these declines in strain during anthracycline-based chemotherapy. Participants with lymphoma receiving anthracyclines were randomized to either placebo or atorvastatin. The study included 150 patients in the placebo group. Article 3: The inflammation-microvascular axis in prognosis: Integrated FAI and AMR assessment for risk stratification after PCI in NSTEMI patients. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41875953 Summary: Patients with non-S. T. minus segment elevation myocardial infarction (N. S. T. E. M. I.) remain at risk of major adverse cardiovascular events (MACE) despite successful percutaneous coronary intervention (P. C. I.). The combined prognostic value of pericoronary fat attenuation index (F. A. I.), a marker of coronary inflammation from coronary computed tomography angiography (C. C. T. A.), and angiography-derived microcirculatory resistance (A. M. R.), a marker of microvascular dysfunction, is underexplored for these patients. This retrospective cohort study assessed this combined prognostic value for improving risk stratification after P. C. I. in N. S. T. E. M. I. patients. Article 4: METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41873711 Summary: The study found that M. E. T. T. L. 14 inhibits atherogenesis by epigenetically activating Peroxisome Proliferator-Activated Receptors alpha and gamma (P. P. A. R. minus alpha and P. P. A. R. minus gamma) transcription. This mechanism promotes fatty acid oxidation in Vascular Smooth Muscle Cells (V. S. M. C.s). M. E. T. T. L. 14 therefore plays a crucial role in governing cellular processes that regulate atherosclerosis development. Article 5: THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41873540 Summary: Thrombospondin-4 (THBS4), an Extracellular Matrix (E. C. M.) glycoprotein, regulates pulmonary vascular remodeling in pulmonary hypertension (P. H.). The study found that T. H. B. S. 4 exerts this regulation via Transforming Growth Factor beta / S. M. A. D. 2 (T. G. F. minus beta / S. M. A. D. 2) signaling. This mechanism contributes to the progressive nature of P. H. marked by pulmonary arterial remodeling and right ventricular dysfunction. Transcript Today’s da

Welcome to Cardiology Today – Recorded March 24, 2026. This episode summarizes 5 key cardiology studies on topics like transitions of care and biomarkers. Key takeaway: Tricuspid Regurgitation Drives Liver Disease Risk. Article Links: Article 1: Myocardial bridging: a practical guide for clinicians. (European heart journal) Article 2: Liver-related outcomes in patients with tricuspid regurgitation. (European journal of heart failure) Article 3: Decoding the Heart Failure Peptidome. (Circulation. Heart failure) Article 4: Update on Education for Families and Patients With Pediatric Heart Disease: A Focus on Technological Advancements, Procedures, and Transitions of Care: A Scientific Statement From the American Heart Association. (Journal of the American Heart Association) Article 5: Angiographic and histological characterization of PFA-induced coronary spasm: Differential effect of two waveforms. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/tricuspid-regurgitation-drives-liver-disease-risk-03-24-26/ Featured Articles Article 1: Myocardial bridging: a practical guide for clinicians. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41873713 Summary: This guide for clinicians identifies myocardial bridging as the most common congenital coronary anomaly. While often a benign anatomical variant without clinical significance, it is increasingly identified due to the greater use of coronary computed tomography angiography. The guide compiles practical information for clinicians on the assessment and management of myocardial bridging. It outlines key considerations for when this condition may become clinically significant and require intervention. Article 2: Liver-related outcomes in patients with tricuspid regurgitation. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41873743 Summary: This retrospective study assessed the incidence and risk of liver-related outcomes in patients with tricuspid regurgitation. Results revealed a clear association between tricuspid regurgitation severity and the development of adverse liver-related complications, including cirrhosis, hepatocellular carcinoma, and liver-related death. The study successfully identified specific predictors for cirrhosis in patients with moderate or greater tricuspid regurgitation. The data also demonstrated a significant negative impact of cirrhosis on overall patient survival. Article 3: Decoding the Heart Failure Peptidome. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41874184 Summary: This cross-sectional mass spectrometry analysis explored the low molecular peptidome in 486 patients with heart failure and 98 age-matched non-heart failure controls. The study identified specific plasma peptides that showed distinct differential expression patterns between heart failure patients and control individuals. These findings significantly advance the understanding of heart failure biology and demonstrate substantial potential for improving the diagnosis and prognostication of heart failure. The identified peptidome signatures offer novel insights for developing future therapeutic strategies for patients with heart failure. Article 4: Update on Education for Families and Patients With Pediatric Heart Disease: A Focus on Technological Advancements, Procedures, and Transitions of Care: A Scientific Statement From the American Heart Association. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41870283 Summary: The American Heart Association issued a scientific statement detailing significant advancements in pediatric heart care models and interventions over the past 20 years. These improvements have led to enhanced clinical outcomes after invasive cardiac procedures, increasing the frequency and complexity of home-based care for children. The statement emphasizes the critical need for updated educational strategies tailored for families and patients. It focuses on integrating technological advancements and improving transitions of care to better support pediatric patients living with heart disease. Article 5: Angiographic and histological characterization of PFA-induced coronary spasm: Differential effect of two waveforms. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871647 Summary: This study characterized pulsed field ablation-induced coronary vasospasm by comparing a clinically relevant full pulsed field ablation waveform against a single-pulse configuration. Results revealed differential effects of the two waveforms on vasospasm incidence, severity, and recovery kinetics. The study also identified specific associated histological changes, providing crucial insights into the physiopathological mechanisms of pulsed field ablation-related coronary spasm. These findings demonstrate that distinct waveform characteristics directly impact the risk and nature of co

Welcome to Cardiology Today – Recorded March 24, 2026. This episode summarizes 5 key cardiology studies on topics like residual pulmonary hypertension and heart transplantation. Key takeaway: H. O. P. E. Extends Heart Transplant Window. Article Links: Article 1: Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial. (European heart journal) Article 2: Twenty-Four-Hour Hypothermic Oxygenated Perfusion Preserves Graft Viability in a Porcine DCD and DBD Heart Transplant Model. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Long term effects of medical therapy pre- and post- pulmonary endarterectomy – insights from the UK CURATE registry. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Association of Pre-Transplant Torque Teno Virus Load With Early Post-Transplant Outcomes in Lung Transplant Recipients: A Multicenter Cohort Study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/h-o-p-e-extends-heart-transplant-window-03-24-26/ Featured Articles Article 1: Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41493330 Summary: The OPTION-STEMI trial found an ongoing clinical uncertainty regarding the optimal timing of complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease complicated by heart failure. This study established a direct comparison of immediate versus staged complete revascularization during the index admission. The trial’s design rigorously evaluated fractional flow reserve-guided complete revascularization for non-infarct-related arteries in this high-risk cohort. Article 2: Twenty-Four-Hour Hypothermic Oxygenated Perfusion Preserves Graft Viability in a Porcine DCD and DBD Heart Transplant Model. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871747 Summary: The study found that 24-hour hypothermic oxygenated perfusion (H. O. P. E.) successfully preserved graft viability in a porcine heart transplant model. This innovative approach extended preservation time up to 24 hours for both donation after circulatory death (D. C. D.) and donation after brain death (D. B. D.) donor hearts. H. O. P. E. demonstrated efficacy in mitigating organ injury, which is a known risk associated with prolonged standard static cold storage exceeding 4 to 5 hours. Article 3: Long term effects of medical therapy pre- and post- pulmonary endarterectomy – insights from the UK CURATE registry. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871746 Summary: The U. K. CURATE registry revealed limited and conflicting evidence regarding the use of pulmonary hypertension (P. H.) medical therapy as a bridge to pulmonary endarterectomy (P. E. A.) for chronic thromboembolic pulmonary hypertension (C. T. E. P. H.). The study also demonstrated an absence of consensus on criteria for continuing or restarting P. H. medical therapy post-operatively. The registry provided crucial data on the characteristics and long-term outcomes of patients receiving P. H. bridging therapy, along with identifying characteristics of residual P. H. post-P. E. A. Article 4: Association of Pre-Transplant Torque Teno Virus Load With Early Post-Transplant Outcomes in Lung Transplant Recipients: A Multicenter Cohort Study. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871745 Summary: A multicenter cohort study involving 334 adult first-time lung transplant recipients established that pre-transplant Torque teno virus (T. T. V.) load is a significant factor in early post-transplant outcomes. This study demonstrated the relevance of T. T. V. levels, recognized as a surrogate marker of net immunosuppression, for lung transplantation patient care. The primary endpoint investigated was infection within 3 months, with plasma samples systematically collected immediately prior to transplantation. Article 5: Residual left atrial v wave predicts clinical outcome of transcatheter edg

Welcome to Cardiology Today – Recorded March 23, 2026. This episode summarizes 5 key cardiology studies on topics like adverse pregnancy outcomes and sleep apnea. Key takeaway: Adverse Pregnancy Outcomes Predict Heart Risk. Article Links: Article 1: Initial Pediatric Experience of Preserving Cardiac Allografts in a 10°C Cooler. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Temporary Mechanical Circulatory Support in LVAD Candidates with Right Ventricular Dysfunction: Acuity Without Long-Term Futility. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Natural History of Tricuspid Regurgitation Following Transcatheter-Edge-to – Edge Repair; Insights from Clinical Trials and Multi-Center Registries. (The Canadian journal of cardiology) Article 4: Win Ratio Analysis for Peak-flow Adaptive Servo-ventilation in Treating Sleep Apnea in Heart Failure with Reduced Ejection Fraction. (The Canadian journal of cardiology) Article 5: Lifetime Adverse Pregnancy Outcome History and Cardiovascular Risk. (Hypertension (Dallas, Tex. : 1979)) Full episode page: https://podcast.explainheart.com/podcast/adverse-pregnancy-outcomes-predict-heart-risk-03-23-26/ Featured Articles Article 1: Initial Pediatric Experience of Preserving Cardiac Allografts in a 10°C Cooler. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41865850 Summary: This study reported the initial pediatric experience of preserving cardiac allografts using a 10 degree Celsius cooler, a method with established favorable results in adult cardiac transplants. The single-center retrospective review documented recipient characteristics, intraoperative courses, and postoperative outcomes associated with this preservation technique. This investigation represents the first clinical application and evaluation of 10 degree Celsius allograft preservation in pediatric patients. Article 2: Temporary Mechanical Circulatory Support in LVAD Candidates with Right Ventricular Dysfunction: Acuity Without Long-Term Futility. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41865849 Summary: V. A. D. Candidates with Right Ventricular Dysfunction: Acuity Without Long-Term Futility. This study found that temporary mechanical circulatory support, utilized as a bridge to durable Left Ventricular Assist Device implantation in advanced heart failure patients with right ventricular dysfunction, indicates acuity without leading to long-term futility. While right ventricular dysfunction at Left Ventricular Assist Device implantation predicts early morbidity and mortality, the data demonstrated that temporary mechanical circulatory support does not independently contribute to long-term risk. This redefines the prognostic implications of preoperative temporary mechanical circulatory support in this vulnerable patient population. Article 3: Natural History of Tricuspid Regurgitation Following Transcatheter-Edge-to – Edge Repair; Insights from Clinical Trials and Multi-Center Registries. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41865992 Summary: This study found that transcatheter edge-to-edge repair for significant tricuspid regurgitation achieved sustained improvement in most patients at one-year follow-up, based on contemporary registries. The data showed that early reduction in tricuspid regurgitation was influenced by factors such as anatomic complexity, leaflet coaptation mechanics, and device-related characteristics. Furthermore, results demonstrated that late tricuspid regurgitation recurrence was primarily driven by ongoing right-sided chamber remodeling and interactions between the leaflets and the device clip. Article 4: Win Ratio Analysis for Peak-flow Adaptive Servo-ventilation in Treating Sleep Apnea in Heart Failure with Reduced Ejection Fraction. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41865991 Summary: This study employed a win ratio analysis to evaluate the effects of peak flow triggered adaptive servo-ventilation for sleep apnea in patients with Heart Failure with Reduced Ejection Fraction. The win ratio approach expanded the assessment of intervention effects beyond conventional morbid and mortal events, incorporating endpoints related to symptom relief and quality of life. This analysis provided a more comprehensive understanding of adaptive servo-ventilation’s impact on overall patient well-being in this specific cardiology population. Article 5: Lifetime Adverse Pregnancy Outcome History and Cardiovascular Risk. Journ

Welcome to Cardiology Today – Recorded March 22, 2026. This episode summarizes 5 key cardiology studies on topics like cardiac surgery and sex-based differences. Key takeaway: Suv39h1 Deficiency Rescues Heart Failure. Article Links: Article 1: Sex-Based Differences in Outcomes Following Mitral Valve Surgery: A Contemporary Analysis From 2 Institutions. (Journal of the American Heart Association) Article 2: The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension. (Cardiovascular research) Article 3: Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2. (Cardiovascular research) Article 4: Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia. (Cardiovascular research) Article 5: Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/suv39h1-deficiency-rescues-heart-failure-03-22-26/ Featured Articles Article 1: Sex-Based Differences in Outcomes Following Mitral Valve Surgery: A Contemporary Analysis From 2 Institutions. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859896 Summary: A comprehensive retrospective cohort study involving 3313 adult patients who underwent mitral valve surgery provided data to investigate sex as an independent risk factor for perioperative mortality. The analysis focused on operative mortality as the primary outcome, stratified by patient sex. This research established a foundational dataset to clarify the influence of sex on surgical outcomes in mitral valve disease. Article 2: The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41861066 Summary: S. H.) Working Group on Environment in Hypertension. A position paper by the European Society of Hypertension Working Group found that environmental pollution and climate change contribute to over 9 million premature deaths annually worldwide. Air and noise pollution demonstrate the strongest epidemiological links to hypertension and cardiovascular disease. Furthermore, emerging evidence connects light pollution, toxic metal exposure, and climate-related factors to these health burdens. This comprehensive analysis highlights the significant impact of environmental factors on global hypertension rates. Article 3: Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41861065 Summary: This study found that a deficiency in suppressor of variegation 3-9 homolog 1, or Suv39h1, attenuates cardiac fibrosis and rescues heart failure. The research demonstrated that Suv39h1 expression increased in cardiac fibroblasts during fibrosis. This mechanism was identified to operate through TACC2, suggesting a critical role for Suv39h1 in regulating cardiac extracellular matrix production. These findings reveal a novel therapeutic target for heart failure. Article 4: Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41861053 Summary: This study found that nuclear export mediated by COPS5/CSN5/JAB1 facilitates vascular smooth muscle cell dedifferentiation, contributing to neointimal hyperplasia. The research showed increased COPS5/CSN5 levels in human idiopathic pulmonary hypertension (I. P. A. H.) neointima, atherosclerotic lesions, and rabbit vein grafts. This suggests a direct involvement of COPS5 in vascular remodeling following injury. Understanding this mechanism offers a potential therapeutic target for conditions involving neointimal hyperplasia. Article 5: Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41854369 Summary: This study found that Lgi3 and Lgi4 proteins interact directly with K. V. 1.5 channels in human atrial tissue and heterologous cells. In a mouse model with A. A. V. 9-mediated cardiac-specific Lgi4 expression, the research observed impaired sinoatrial and atrioventricular conduction, leading to a prolonged Q. R. S. interval. The data showed delayed action potential repolarization in atria, indicating Lgi3-4 proteins modulate cardiac electrophysiology. These findings suggest Lgi3-4 proteins are potential therapeutic targets for atrial fibrillation. Transcript Today&#821

Welcome to Cardiology Today – Recorded March 21, 2026. This episode summarizes 5 key cardiology studies on topics like coronary artery disease and Time-restricted eating. Key takeaway: Apixaban Safe for Kids’ Heart Thromboprophylaxis. Article Links: Article 1: Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study. (Journal of the American Heart Association) Article 2: Association of Multiple Plasma Metals With Cerebral Microbleeds: A Brain Magnetic Resonance Imaging-Based Study. (Journal of the American Heart Association) Article 3: Prior Antiplatelet Exposure and Clinical Outcomes Among Korean Patients With Acute Myocardial Infarction. (Journal of the American Heart Association) Article 4: Ex Vivo Effect of Apixaban on Hemostatic Biomarkers in Children With Heart Disease: A SAXOPHONE Trial Substudy. (Journal of the American Heart Association) Article 5: Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/apixaban-safe-for-kids-heart-thromboprophylaxis-03-21-26/ Featured Articles Article 1: Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859904 Summary: A randomized-controlled crossover study investigated a two-week time-restricted eating intervention, allowing eating only between 8 a.m. and 2 p.m., in patients with a history of myocardial infarction. The research explored the intervention’s effects on metabolomic parameters and innate immune cell function. This study provided a structured assessment of time-restricted eating as a potential modulator of inflammation and immune cell function in established coronary artery disease. Article 2: Association of Multiple Plasma Metals With Cerebral Microbleeds: A Brain Magnetic Resonance Imaging-Based Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859900 Summary: This cross-sectional study found an association between multiple plasma metals and cerebral microbleeds, with detection performed using brain magnetic resonance imaging. The research identified that environmental metal exposure and systemic metal circulation are factors related to cerebrovascular health. This study provided direct data on the connections between various plasma metals and the presence of cerebral microbleeds. Article 3: Prior Antiplatelet Exposure and Clinical Outcomes Among Korean Patients With Acute Myocardial Infarction. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859899 Summary: A retrospective cohort study of 29281 Korean patients with acute myocardial infarction found that prior antiplatelet exposure was a factor influencing clinical outcomes. The study identified patient cohorts that specifically excluded individuals with pre-existing atrial fibrillation, coronary artery disease, heart failure, cerebrovascular accident, or prior thrombolysis. This research provided concrete findings on how antiplatelet medication history impacts prognosis in an East Asian population, which is characterized by distinct antithrombotic response profiles. Article 4: Ex Vivo Effect of Apixaban on Hemostatic Biomarkers in Children With Heart Disease: A SAXOPHONE Trial Substudy. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859898 Summary: The SAXOPHONE (Safety of Apixaban on Pediatric Heart Disease on the Prevention of Embolism) trial definitively demonstrated the safety of apixaban for thromboprophylaxis in children with heart disease. An exploratory substudy assessed apixaban’s ex vivo effects on surrogate biomarkers of efficacy, including D-dimer, thrombin generation assay parameters, Factor eight, fibrinogen, and protein C. This research provided specific data on apixaban’s impact on coagulation factors and hemostatic proteins in this pediatric patient group. Article 5: Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859897 Summary: This study evaluated the real-world relationship between pulmonary vascular resistance and prognosis in Group two pulmonary hypertension, which is defined as pulmonary hypertension caused by left heart disease. Researchers analyzed data from 563 patients across two prospective Japanese multicenter registries, thus establishing specific patient cohorts for

Welcome to Cardiology Today – Recorded March 21, 2026. This episode summarizes 5 key cardiology studies on topics like premature menopause and sodium-glucose cotransporter two inhibitors. Key takeaway: ECG AI Predicts AF Recurrence Risk. Article Links: Article 1: Premature Menopause and Lifetime Risk of Coronary Heart Disease. (JAMA cardiology) Article 2: Life expectancy and determinants of relative survival following surgical aortic valve replacement for aortic stenosis. (Heart (British Cardiac Society)) Article 3: Real-world evidence with dapagliflozin in heart failure with reduced ejection fraction in Central Eastern Europe and the Baltic region (EVOLUTION-HF CEE-BA Study). (ESC heart failure) Article 4: Comparative diagnostic performance of machine learning models and traditional scores for HFpEF in older adults. (European journal of heart failure) Article 5: Predicting Recurrence and Outcomes After Stressor-Associated Atrial Fibrillation Using ECG-Based Deep Learning. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/ecg-ai-predicts-af-recurrence-risk-03-21-26/ Featured Articles Article 1: Premature Menopause and Lifetime Risk of Coronary Heart Disease. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41848694 Summary: The study found that premature onset of menopause is associated with an increased short-term risk of coronary heart disease. Researchers calculated lifetime risk estimates of incident coronary heart disease and estimated years lived free of and with coronary heart disease. These estimates were stratified by premature menopause status and self-identified race across 163600 person-years of follow-up. The findings highlight the critical long-term cardiovascular implications of premature menopause across diverse populations. Article 2: Life expectancy and determinants of relative survival following surgical aortic valve replacement for aortic stenosis. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41850785 Summary: Surgical aortic valve replacement improves survival in patients with severe, symptomatic aortic stenosis. This study evaluated the long-term relative survival of patients after surgical aortic valve replacement compared with the general population. Researchers identified specific predictors of any residual survival discrepancies among 1287 patients who received surgical aortic valve replacement for moderate or greater aortic stenosis. These findings provide clarity on life expectancy post-surgical aortic valve replacement and factors influencing it. Article 3: Real-world evidence with dapagliflozin in heart failure with reduced ejection fraction in Central Eastern Europe and the Baltic region (EVOLUTION-HF CEE-BA Study). Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41858299 Summary: F. C.E.E.-B.A. Study). Sodium-glucose cotransporter two inhibitors are currently recommended as one of the four pillars of treatment in Heart Failure with Reduced Ejection Fraction. This study characterized the real-world patient population initiated on dapagliflozin for Heart Failure with Reduced Ejection Fraction in clinical practice. The data came from nine countries across Central Eastern Europe and the Baltic Area, providing crucial real-world insights following dapagliflozin’s 2020 approval. The findings offer valuable information on therapeutic adoption and patient profiles in diverse European regions. Article 4: Comparative diagnostic performance of machine learning models and traditional scores for HFpEF in older adults. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859834 Summary: F. pEF in older adults. This study evaluated the diagnostic performance of four supervised machine learning algorithms for identifying Heart Failure with Preserved Ejection Fraction in individuals aged 60 to 80 years. The study found that machine learning approaches improved diagnostic accuracy when compared to traditional Heart Failure with Preserved Ejection Fraction scores. This demonstrates the superior utility of advanced computational methods in diagnosing this challenging condition in older adult populations. Article 5: Predicting Recurrence and Outcomes After Stressor-Associated Atrial Fibrillation Using ECG-Based Deep Learning. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859908 Summary: The study retrospectively analyzed patients with stressor-associated atrial fibrillation to predict recurrence and outcomes. It found that artificial intelligence-enabled models using the 12-lead electrocardiogram could accurately estimate the risk of recurrence. These models proved valuable in identifying individuals at highest risk for atrial fibrillation recurrence, which traditional clinical factors have shown limited utility in achieving. This represents a significant advancemen

Welcome to Cardiology Today – Recorded March 21, 2026. This episode summarizes 5 key cardiology studies on topics like immunosuppression and severe heart failure. Key takeaway: New Immunoassay Boosts Pediatric Transplant Safety. Article Links: Article 1: African Representation in Randomized Controlled Trials Published in Leading Medical and Cardiovascular Journals, 2019-2024. (Journal of the American College of Cardiology) Article 2: Genetic counselling implementation in dilated cardiomyopathy. (European heart journal) Article 3: “Real-world prognostic performance of different severe and advanced heart failure definitions: data from the Swedish Heart Failure Registry”. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Safety and Immunogenicity of Varicella-Zoster Vaccination in Pediatric Heart Transplant Recipients. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Advancing ABO-Histocompatibility: Impact of Multiplexed ABO Antibody Immunoassay to Increase Precision in Pediatric Heart Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/new-immunoassay-boosts-pediatric-transplant-safety-03-21-26/ Featured Articles Article 1: African Representation in Randomized Controlled Trials Published in Leading Medical and Cardiovascular Journals, 2019-2024. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41860521 Summary: Significant underrepresentation of African countries was observed in randomized controlled trials published in leading medical and cardiovascular journals. This disparity profoundly affects the generalizability of clinical evidence to a substantial portion of the global population with significant disease burden. Acknowledging this lack of representation is crucial for advancing equitable research practices and ensuring cardiovascular care benefits diverse patient groups. Article 2: Genetic counselling implementation in dilated cardiomyopathy. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41858107 Summary: Genetic testing has become an integral component of the diagnostic process for patients with dilated cardiomyopathy. Its relevance has expanded significantly beyond identifying at-risk family members, now informing crucial clinical decision-making. The understanding of dilated cardiomyopathy’s genetic architecture demonstrates a shift from a monogenic dogma towards a broader polygenic spectrum. Article 3: “Real-world prognostic performance of different severe and advanced heart failure definitions: data from the Swedish Heart Failure Registry”. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41862040 Summary: A valid definition of severe heart failure with reduced ejection fraction is critical for timely patient identification and referral to advanced therapies. Such definitions are also essential for optimizing the design of clinical trials in this patient population. Real-world data from the Swedish Heart Failure Registry, encompassing over 15000 patients, underscores the importance of assessing the prevalence and prognostic performance of different severe and advanced heart failure definitions for precise patient management. Article 4: Safety and Immunogenicity of Varicella-Zoster Vaccination in Pediatric Heart Transplant Recipients. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41862039 Summary: Pediatric heart transplant recipients face increased morbidity and mortality from vaccine-preventable infections due to long-term immunosuppression. While live vaccines have traditionally been contraindicated post-transplant, evolving clinical evidence supports their administration in selected solid organ recipients. This shift highlights a critical need to assess the safety and immunogenicity of specific live vaccines, like the varicella-zoster virus vaccine, in this vulnerable patient population. Article 5: Advancing ABO-Histocompatibility: Impact of Multiplexed ABO Antibody Immunoassay to Increase Precision in Pediatric Heart Transplantation. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41862036 Summary: B. O.-Histocompatibility: Impact of Multiplexed A. B. O. Antibody Immunoassay to Increase Precision in Pediatric Heart Transplantation. Accurate measurement of

Welcome to Cardiology Today – Recorded March 20, 2026. This episode summarizes 5 key cardiology studies on topics like Waitlist outcomes and Chagas cardiomyopathy. Key takeaway: Medical Urgency Drives 40.6% Lung Transplant Priority.. Article Links: Article 1: Sacubitril-Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: Primary Results of ANSWER-HF Randomized Trial. (Journal of the American College of Cardiology) Article 2: Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial. (Circulation) Article 3: Influence of U.S. Lung Composite Allocation Score Components on Transplant Candidate Prioritization. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Multi-center Open-Label Tacrolimus Inhalation Powder (TIP) Trial Evaluating Safety, Tolerability, Efficacy and Pharmacokinetics in Adult Lung Transplant Recipients with Significant Renal Impairment. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Pediatric lung transplantation in Japan across legislative and allocation reforms: a nationwide registry analysis of waitlist and post-transplant outcomes. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/medical-urgency-drives-40-6-lung-transplant-priority-03-20-26/ Featured Articles Article 1: Sacubitril-Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: Primary Results of ANSWER-HF Randomized Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41396086 Summary: The A. N. S. W. E. R. minus H. F. trial investigated the efficacy of sacubitril-valsartan compared to enalapril in patients with Chagas cardiomyopathy and heart failure with reduced ejection fraction. This study specifically evaluated effects on cardiac remodeling, functional outcomes, biomarkers, and safety. The trial addressed a critical knowledge gap regarding treatment for a common cause of heart failure with reduced ejection fraction in Latin America. Article 2: Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41853846 Summary: A phase two randomized clinical trial investigated memantine as a novel pharmacological therapy for premature atrial contractions. Preclinical studies previously found that pharmacological antagonism of N-methyl-D-aspartate receptors with memantine suppressed atrial arrhythmias. This current trial leveraged the identified functional cardiac glutamatergic system to assess a new approach for suppressing premature atrial contractions. Article 3: Influence of U.S. Lung Composite Allocation Score Components on Transplant Candidate Prioritization. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41856261 Summary: Lung Composite Allocation Score Components on Transplant Candidate Prioritization. An analysis of the U. S. Composite Allocation Score system for lung transplant prioritization found that medical urgency was responsible for 40.6 percent of the variation in total scores. This occurred despite medical urgency constituting only 25 of the 100 possible Composite Allocation Score points. The study quantified each component’s contribution to total Composite Allocation Score variability following the system’s implementation in March 2023. Article 4: Multi-center Open-Label Tacrolimus Inhalation Powder (TIP) Trial Evaluating Safety, Tolerability, Efficacy and Pharmacokinetics in Adult Lung Transplant Recipients with Significant Renal Impairment. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41856260 Summary: Oral tacrolimus, a critical immunosuppressant after lung transplantation, is associated with significant renal impairment. Tacrolimus Inhalation Powder represents a therapeutic strategy designed to deliver the drug locally, potentially preventing graft rejection with lower systemic drug levels. This approach was investigated in adult lung transplant recipients with existing renal impairment to address the problem of tacrolimus-induced nephrotoxicity. Article 5: Pediatric lung transplantation in Japan across legislative and allocation reforms: a nationwide registry analysis of waitlist and post-transplant outcomes. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41856259 Summary: A nationwide registry analy

Welcome to Cardiology Today – Recorded March 19, 2026. This episode summarizes 5 key cardiology studies on topics like functional mitral regurgitation and quality of care. Key takeaway: New Echo Criteria Tested for H. F. pEF. Article Links: Article 1: Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation. (The New England journal of medicine) Article 2: Atrial Functional Mitral Regurgitation: Effect of Phenotype Definition on Classification, Valve Features, and Prognosis. (Journal of the American College of Cardiology) Article 3: Ethnicity and Heart Failure Outcomes in England: Role of Specialist Care in a Universal Health System. (Journal of the American College of Cardiology) Article 4: Cardiomyopathy Gene Variants and Polygenic Risk Scores in Atrial Fibrillation: Evidence for an Atrial-First Phenotype. (Journal of the American College of Cardiology) Article 5: Echocardiographic Diastolic Function Grading in HFpEF: Testing the Updated 2025 ASE Criteria. (Journal of the American College of Cardiology) Full episode page: https://podcast.explainheart.com/podcast/new-echo-criteria-tested-for-h-f-pef-03-19-26/ Featured Articles Article 1: Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41849741 Summary: The clinical question concerns the effectiveness of catheter-based Left Atrial Appendage Closure as an alternative to oral anticoagulation for stroke prevention in atrial fibrillation patients. This study investigated its efficacy compared to physician-directed best medical care in those at high risk for both stroke and bleeding. A multicenter randomized trial in Germany examined this critical comparison. The research addresses the optimal therapeutic strategy for this complex patient population. Article 2: Atrial Functional Mitral Regurgitation: Effect of Phenotype Definition on Classification, Valve Features, and Prognosis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41848471 Summary: This article highlights Atrial functional Mitral Regurgitation (AfMR) as a distinct and clinically significant form of functional mitral regurgitation. It found that disparate published definitions create significant uncertainty regarding its prevalence, specific morphology, and associated mortality. This definitional inconsistency was shown to impede consistent clinical decision making and patient classification. The analysis underscores the critical need for a unified and broadly applicable definition to improve management. Article 3: Ethnicity and Heart Failure Outcomes in England: Role of Specialist Care in a Universal Health System. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41848357 Summary: Reports indicated poorer cardiovascular outcomes among ethnic minorities, especially during the COVID-19 pandemic. This analysis investigated the relationship between ethnicity, quality of care after heart failure hospitalization, and long-term outcomes in England. The study utilized routinely collected national audit data to examine these disparities within a universal health system. It focused on understanding how ethnicity influences care quality and subsequent long-term outcomes for patients hospitalized with acute heart failure. Article 4: Cardiomyopathy Gene Variants and Polygenic Risk Scores in Atrial Fibrillation: Evidence for an Atrial-First Phenotype. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706057 Summary: The genetic substrate of atrial fibrillation (A. F.) is heritable and complex. This study explored the impact of disease-causing cardiomyopathy variants on the risk of A. F., even after accounting for incident ventricular cardiomyopathy and clinical heart failure. Researchers evaluated the utility of polygenic risk scores (P. R. S.) to further differentiate between atrial and ventricular phenotypes in gene variant carriers. The findings provided evidence supporting an “atrial-first phenotype” in the context of cardiomyopathy gene variants and A. F. risk. Article 5: Echocardiographic Diastolic Function Grading in HFpEF: Testing the Updated 2025 ASE Criteria. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41532943 Summary: F. pEF: Testing the Updated 2025 A. S. E. Criteria. The American Society of Echocardiography (A. S. E.) recently proposed an updated 2025 algorithm for echocardiographic grading of left ventricular diastolic function. This study systematically evaluated the new A. S. E. algorithm specifically in patients with invasively confirmed ambulatory Heart Failure with Preserved Ejection Fraction (H. F. pEF). The investigation determined the false-negative rate of this algorithm within this patient population. It assessed the diagnostic accuracy of th

Welcome to Cardiology Today – Recorded March 18, 2026. This episode summarizes 5 key cardiology studies on topics like cDPP3 and endovascular revascularization. Key takeaway: Simtuzumab Preserves Cardiac Function in LMNA DCM. Article Links: Article 1: cDPP3 and Outcomes in Acute Heart Failure: An Analysis of the STRONG-HF and CORTAHF Studies. (ESC heart failure) Article 2: Long-term Safety and Performance of an Implantable IVC Sensor for Congestion-Guided Management in Heart Failure: 12-Month Results from the FUTURE-HF Trial Portfolio. (European journal of heart failure) Article 3: Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in LMNA Mutation-Induced Dilated Cardiomyopathy. (Circulation. Heart failure) Article 4: Safety and Effectiveness of the Santreva-ATK Endovascular Revascularization Catheter in the RESTOR-1 Peripheral CTO Crossing Pivotal Study. (The American journal of cardiology) Article 5: Procedural Complexity and Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/simtuzumab-preserves-cardiac-function-in-lmna-dcm-03-18-26/ Featured Articles Article 1: cDPP3 and Outcomes in Acute Heart Failure: An Analysis of the STRONG-HF and CORTAHF Studies. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41834515 Summary: Circulating dipeptidyl peptidase 3 (cDPP3) is an established biomarker for cardiocirculatory failure, with elevated concentrations predicting poor patient outcomes in shock states. Researchers analyzed cDPP3 levels at baseline and follow-up in patients with acute heart failure enrolled in the STRONG-HF and CORTAHF trials. This investigation centered on the associations of cDPP3 with 180-day and 90-day outcomes, respectively. The evaluation of cDPP3 in acute heart failure provides crucial insights into the identification of prognostic indicators for improved risk stratification in this patient population. Article 2: Long-term Safety and Performance of an Implantable IVC Sensor for Congestion-Guided Management in Heart Failure: 12-Month Results from the FUTURE-HF Trial Portfolio. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41841702 Summary: V. C. Sensor for Congestion-Guided Management in Heart Failure: 12-Month Results from the FUTURE-HF Trial Portfolio. An implantable inferior vena cava (I. V. C.) sensor was utilized for 12 months in a congestion-guided management strategy for heart failure patients. Data from 65 patients in the FUTURE-HF and FUTURE-HF two trials, predominantly with New York Heart Association class three symptoms and Heart Failure with Reduced Ejection Fraction, were analyzed. Daily I. V. C. parameters were recorded, and adjudicated safety outcomes were assessed. This study demonstrates the application of continuous physiological monitoring to address the critical challenge of congestion in heart failure. Article 3: Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in LMNA Mutation-Induced Dilated Cardiomyopathy. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41841259 Summary: Simtuzumab attenuated Loxl2-mediated extracellular matrix remodeling and preserved cardiac function in dilated cardiomyopathy caused by LMNA mutations. This severe cardiac condition is marked by arrhythmias, contractile dysfunction, and excessive myocardial fibrosis, impairing left ventricular function and increasing heart failure risk. The findings identify simtuzumab as a therapeutic agent that addresses the pathogenesis of LMNA mutation-induced dilated cardiomyopathy. This represents a significant step towards developing targeted therapies for this specific genetic heart disease. Article 4: Safety and Effectiveness of the Santreva-ATK Endovascular Revascularization Catheter in the RESTOR-1 Peripheral CTO Crossing Pivotal Study. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41571040 Summary: T. K. Endovascular Revascularization Catheter in the RESTOR-1 Peripheral C. T. O. Crossing Pivotal Study. The Santreva-A. T. K. Endovascular Revascularization Catheter demonstrated its safety and effectiveness in the RESTOR-1 Peripheral Chronic Total Occlusion Crossing Pivotal Study. This prospective, multicenter trial included adult patients with Rutherford class two to five peripheral arterial disease and de novo femoropopliteal chronic total occlusions. The catheter successfully provided a mechanism for recanalization, addressing the challenges of traversing chronic total occlusions. This study establishes a new option for endovascular revascularization in complex peripheral arterial disease patients. Article 5: Procedural Complexity and Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention. Journal: The American journal of cardiology

Welcome to Cardiology Today – Recorded March 18, 2026. This episode summarizes 5 key cardiology studies on topics like acute hypoxemic respiratory failure and dose reduction. Key takeaway: P. C. S. K. 9 Inhibitors Slash Cardiovascular Risk. Article Links: Article 1: High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure. (The New England journal of medicine) Article 2: Prehospital Whole Blood in Traumatic Hemorrhage – a Randomized Controlled Trial. (The New England journal of medicine) Article 3: Proprotein convertase subtilisin/kexin Type 9 inhibitors: past, present, and future. (European heart journal) Article 4: Senescence-associated metabolic alterations aggravate calcific aortic valve disease. (European heart journal) Article 5: Long-term outcomes following Sacubitril/Valsartan therapy for chronic HFrEF. Italian Real-World Multicenter Study. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/p-c-s-k-9-inhibitors-slash-cardiovascular-risk-03-18-26/ Featured Articles Article 1: High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41841715 Summary: A multicenter trial established a direct comparison of high-flow oxygen and standard oxygen therapy for patients with acute hypoxemic respiratory failure, defined by a partial pressure of arterial oxygen to fraction of inspired oxygen ratio of 200 or less. This research directly evaluated the clinical impact of these oxygen delivery methods on intubation rates and patient mortality. The findings from this investigation provide crucial guidance for optimizing oxygen delivery strategies in critical respiratory care. Article 2: Prehospital Whole Blood in Traumatic Hemorrhage – a Randomized Controlled Trial. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41841706 Summary: A pragmatic phase three randomized controlled trial directly evaluated the clinical effectiveness and safety of prehospital whole blood transfusion in patients with major traumatic hemorrhage. This multicenter study specifically compared whole blood transfusion with standard care in a prehospital setting provided by air ambulance services. The findings from this investigation establish crucial evidence regarding optimal transfusion strategies for severe hemorrhage prior to hospital arrival. This research offers definitive insights into improving early trauma care and patient outcomes. Article 3: Proprotein convertase subtilisin/kexin Type 9 inhibitors: past, present, and future. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41841775 Summary: Proprotein convertase subtilisin/kexin type nine (P. C. S. K. 9) inhibitors have been established as a potent new class of low-density lipoprotein cholesterol-lowering drugs. These inhibitors demonstrate efficacy comparable to and additive with high-intensity statins, alongside an excellent safety profile. Extensive cardiovascular outcomes trials confirmed that monoclonal antibody P. C. S. K. 9 inhibitors significantly reduce the risk of major adverse cardiovascular outcomes across a wide spectrum of patients. This represents a substantial therapeutic advancement for cardiovascular risk management. Article 4: Senescence-associated metabolic alterations aggravate calcific aortic valve disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41841768 Summary: This study demonstrated that senescence-associated metabolic alterations aggravate calcific aortic valve disease, a condition currently without effective pharmacotherapy. Researchers identified a tight link between declining nicotinamide adenine dinucleotide levels with age and the progression of valvular inflammation and calcification. Disruption of specific nicotinamide adenine dinucleotide salvage metabolism was found to drive these detrimental processes within the aortic valve. These findings provide critical mechanistic insights into the pathogenesis of calcific aortic valve disease, highlighting novel therapeutic targets. Article 5: Long-term outcomes following Sacubitril/Valsartan therapy for chronic HFrEF. Italian Real-World Multicenter Study. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41843757 Summary: Italian Real-World Multicenter Study. This Italian real-world multicenter study provided long-term outcomes following sacubitril/valsartan therapy for chronic Heart Failure with reduced Ejection Fraction. The study established longitudinal changes after sacubitril/valsartan initiation and the association between dose changes and major adverse cardiovascular events. Data were collected from 592 outpatients, revealing insights into the real-world effectiveness and optimal dosing strategies of sacubitril/valsartan. This research illuminates the critical impact of treatment adherence and dose management on patient pro

Welcome to Cardiology Today – Recorded March 17, 2026. This episode summarizes 5 key cardiology studies on topics like preventive cardiology and sudden cardiac death. Key takeaway: Left Ventricular Remodeling Post Mitral Repair. Article Links: Article 1: Use of Coronary Artery Calcium Scoring in Individuals With Elevated Lipoprotein(a): A Multicohort Study. (Journal of the American College of Cardiology) Article 2: CRLF1 Secreted by Cardiac Fibroblasts Promotes Human Hypertrophic Cardiomyopathy. (Circulation) Article 3: Sports cardiology for the general cardiologist. (Heart (British Cardiac Society)) Article 4: Left Ventricular Reverse Remodeling after Mitral Transcatheter Edge-to-Edge Repair: Results from the EXPANDed Studies. (ESC heart failure) Article 5: Cardiac Biomarkers Response Under Angiotensin Receptor-Neprilysin Inhibitor: A Sub-Analysis of the Natrium-HF Study. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/left-ventricular-remodeling-post-mitral-repair-03-17-26/ Featured Articles Article 1: Use of Coronary Artery Calcium Scoring in Individuals With Elevated Lipoprotein(a): A Multicohort Study. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41837904 Summary: The current understanding in cardiology indicates that the utility of coronary artery calcium scoring for atherosclerotic cardiovascular disease risk assessment in individuals with elevated lipoprotein(a) is unclear. This ambiguity exists because lipoprotein(a) has a propensity toward non-calcified plaque, complicating traditional calcification-based risk evaluations. This uncertainty highlights a critical gap in refining cardiovascular disease prevention strategies for this specific patient population. Resolving this clinical question is essential for optimizing targeted interventions and improving patient outcomes. Article 2: CRLF1 Secreted by Cardiac Fibroblasts Promotes Human Hypertrophic Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41838796 Summary: R. L. F. 1 Secreted by Cardiac Fibroblasts Promotes Human Hypertrophic Cardiomyopathy. Nearly half of patients diagnosed with hypertrophic cardiomyopathy, the most common inherited cardiac disorder, currently lack identifiable sarcomere gene sequence variations. This significant proportion suggests the presence of undiscovered mechanisms driving the disease’s pathogenesis, highlighting its substantial genetic and clinical heterogeneity. A unified molecular basis underlying hypertrophic cardiomyopathy pathology remains to be fully elucidated. Identifying these unknown pathways is crucial for developing new diagnostic tools and targeted therapeutic interventions. Article 3: Sports cardiology for the general cardiologist. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41839544 Summary: Sports cardiology has emerged as a distinct subspecialty, integrating preventive cardiology with athlete care. While regular exercise provides substantial cardiovascular benefits, vigorous exertion can unmask latent disease and precipitate sudden cardiac death in predisposed individuals. This primer emphasizes the importance of early detection, comprehensive risk stratification, and tailored management strategies for athletes. Such events, though uncommon, carry profound societal impact and necessitate specialized attention from cardiologists. Article 4: Left Ventricular Reverse Remodeling after Mitral Transcatheter Edge-to-Edge Repair: Results from the EXPANDed Studies. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41839533 Summary: Left ventricular reverse remodeling stands as a critical therapeutic objective for contemporary heart failure management, aiming to reverse left ventricular dilation and dysfunction. Achieving this remodeling after mitral transcatheter edge-to-edge repair is a key indicator of successful treatment for both primary and secondary mitral regurgitation. Early indicators of left ventricular reverse remodeling within 30 days are crucial for assessing treatment efficacy and guiding patient prognosis. Understanding specific factors associated with this early remodeling can optimize future clinical decision-making and patient selection. Article 5: Cardiac Biomarkers Response Under Angiotensin Receptor-Neprilysin Inhibitor: A Sub-Analysis of the Natrium-HF Study. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41834516 Summary: F. Study. Natriuretic peptides are recognized as central biomarkers in the diagnostic and therapeutic management of heart failure. However, current understanding of their short-term dynamics during sacubitril/valsartan therapy and in response to acute volume changes remains incomplete. Characterizing these cardiac biomarker responses to angiotensin receptor-neprilysin inhibitor treatment is essential for optimizing patient monitoring and treatment adjustme

Welcome to Cardiology Today – Recorded March 16, 2026. This episode summarizes 5 key cardiology studies on topics like Donor-specific antibody and Heart transplant rejection. Key takeaway: Kidney Injury Drives Diuretic Resistance in A. H. F.. Article Links: Article 1: Net Prolongation of Life in Advanced Heart Failure: An Intentional Strategy of Durable LVAD Therapy Followed by Heart Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Comparing DSA-negative and DSA-positive antibody-mediated rejection in heart transplants: results from the Trifecta-Heart study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Kidney tubule injury is associated with sodium avidity and diuretic responsiveness in acute heart failure. (ESC heart failure) Article 4: Effect of Hypertension Duration on the Associations Between Intensive Blood Pressure Control and Cardiac, Vascular, and Kidney Organ Damage. (Journal of the American Heart Association) Article 5: Hyaluronan and Syndecan-1: Linking Glycocalyx Degradation to Development and Progression of Heart Failure With Preserved Ejection Fraction. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/kidney-injury-drives-diuretic-resistance-in-a-h-f-03-16-26/ Featured Articles Article 1: Net Prolongation of Life in Advanced Heart Failure: An Intentional Strategy of Durable LVAD Therapy Followed by Heart Transplantation. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41833594 Summary: Heart transplantation is an established gold standard therapy for end-stage systolic heart failure, showing a median survival of approximately 10 to 13 years. For younger patients under 50 years of age, the utility of heart transplantation for lifetime management is limited by low re-transplantation rates. Durable left ventricular assist device support is also an established surgical option for these patients. The article identifies an intentional strategy of utilizing durable left ventricular assist device therapy followed by heart transplantation to achieve net prolongation of life in advanced heart failure. Article 2: Comparing DSA-negative and DSA-positive antibody-mediated rejection in heart transplants: results from the Trifecta-Heart study. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41833593 Summary: Antibody-mediated rejection in heart transplants frequently presents without donor-specific antibodies, posing a diagnostic challenge. The Trifecta-Heart study provided characterization of rejection in 212 heart endomyocardial biopsies through the Molecular Microscope Diagnostic System and histology. This research distinguished molecular differences between donor-specific antibody-negative and donor-specific antibody-positive antibody-mediated rejection. Donor-derived cell-free D. N. A., a biomarker for transplant injury, was concurrently measured at the time of biopsy to enhance the understanding of these distinct rejection phenotypes. Article 3: Kidney tubule injury is associated with sodium avidity and diuretic responsiveness in acute heart failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41832743 Summary: Greater sodium avidity in patients with acute heart failure is a known indicator of worse clinical outcomes. This study evaluated 339 participants from the R. O. S. E. hyphen A. H. F. trial, which included patients hospitalized for acute heart failure with kidney dysfunction. The study found that kidney tubule injury, as assessed by urinary biomarkers such as kidney injury molecule-1, N-acetyl-beta-D-glucosaminidase, and neutrophil gelatinase-associated lipocalin, is associated with both increased sodium avidity and impaired diuretic responsiveness. This association provides insight into the underlying mechanisms contributing to poor outcomes in acute heart failure. Article 4: Effect of Hypertension Duration on the Associations Between Intensive Blood Pressure Control and Cardiac, Vascular, and Kidney Organ Damage. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823241 Summary: Intensive systolic blood pressure treatment is a crucial strategy to mitigate cardiovascular disease risk in long-standing hypertension, with target organ damage being a critical intermediate phenotype. This study utilized data from 8442 participants in the S. T. E. P. trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients). The research precisely evaluated the impact of hypertension duration on the

Welcome to Cardiology Today – Recorded March 15, 2026. This episode summarizes 5 key cardiology studies on topics like psychological distress and non-pharmacological therapy. Key takeaway: Chemotherapy Cardiotoxicity Mechanisms Found. Article Links: Article 1: The effect of empagliflozin on left ventricular mass and volumes in elderly individuals with overweight and high risk of heart failure: The Empire Prevent Cardiac Trial. (Journal of cardiac failure) Article 2: Effects of Sauna bathing on Exercise Capacity and Muscle Function in HFpEF. (European journal of heart failure) Article 3: Development and Validation of a Measure of Psychological Distress After Spontaneous Coronary Artery Dissection: The Spontaneous Coronary Artery Dissection Distress Inventory. (Journal of the American Heart Association) Article 4: Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long-Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab-Based Chemotherapy. (Journal of the American Heart Association) Article 5: Factors Associated With Telemedicine Use by Cardiologists for Medicare Beneficiaries in 2022 to 2023: An Observational Study. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/chemotherapy-cardiotoxicity-mechanisms-found-03-15-26/ Featured Articles Article 1: The effect of empagliflozin on left ventricular mass and volumes in elderly individuals with overweight and high risk of heart failure: The Empire Prevent Cardiac Trial. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41831639 Summary: Increased left ventricular mass predicts heart failure, creating a significant focus on preventive strategies. Empagliflozin, a sodium-glucose cotransporter two inhibitor, is being evaluated for its effects on left ventricular mass index and left ventricular volumes. This evaluation targets elderly, overweight individuals who are considered at high risk of developing heart failure. The clinical investigation specifically examines empagliflozin’s role in this at-risk population where the preventive effect of sodium-glucose cotransporter two inhibitors is an area of active research. Article 2: Effects of Sauna bathing on Exercise Capacity and Muscle Function in HFpEF. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41831305 Summary: F. pEF. Treatment options to improve exercise capacity in Heart Failure with Preserved Ejection Fraction remain limited. Investigating new approaches, sauna bathing is undergoing study for its potential to enhance exercise performance, skeletal muscle function, body composition, and patient quality of life in this population. The SAUNA-H. F. pEF study represents the first prospective mechanistic pilot study to evaluate the feasibility, safety, and efficacy of supervised sauna bathing. This research provides a novel therapeutic avenue for stable outpatients with Heart Failure with Preserved Ejection Fraction. Article 3: Development and Validation of a Measure of Psychological Distress After Spontaneous Coronary Artery Dissection: The Spontaneous Coronary Artery Dissection Distress Inventory. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823248 Summary: Spontaneous Coronary Artery Dissection is a highly distressing cause of acute myocardial infarction, for which no specific distress measure existed. Researchers developed and validated the Spontaneous Coronary Artery Dissection Distress Inventory (S. D. I.). This new tool provides a condition-specific measure designed to accurately capture the unique psychological impacts of Spontaneous Coronary Artery Dissection. The S. D. I. addresses the previous reliance on generic anxiety and depression measures, offering a more precise assessment for affected patients. Article 4: Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long-Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab-Based Chemotherapy. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823245 Summary: Long-term survivors of breast cancer treated with doxorubicin and trastuzumab-based chemotherapy show sympathetic neural overactivation, vascular dysfunction, and exercise intolerance. These physiological changes contribute to the increased risk of cardiovascular disease observed in this patient population. The study established these mechanisms as key factors in cardiovascular disease development following specific breast cancer treatments. These findings illuminate the previously unknown physiological underpinnings of cardiotoxicity in these survivors. Article 5: Factors Associated With Telemedicine Use by Cardiologists for Medicare Beneficiaries in 2022 to 2023: An Observational Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.nc

Welcome to Cardiology Today – Recorded March 14, 2026. This episode summarizes 5 key cardiology studies on topics like Pressure microcatheter and Fractional flow reserve. Key takeaway: Finerenone Boosts HFpEF Quality of Life. Article Links: Article 1: Heart failure patients with reduced or mildly reduced ejection fraction: baseline characteristics of the low-dose digoxin outcome DECISION trial. (European journal of heart failure) Article 2: Finerenone and Quality of Life in Heart Failure: Component-Level Analyses and Clinical Relevance of the Kansas City Cardiomyopathy Questionnaire. (European journal of heart failure) Article 3: Infective Endocarditis After Arrythmia Device Implantation in Cardiac Surgery Patients. (Journal of the American Heart Association) Article 4: Impact of Combined Anticoagulant and Antiplatelet Therapy in Older Patients With Atrial Fibrillation: ANAFIE Subanalysis. (Journal of the American Heart Association) Article 5: Clinical Validation of a Novel Pressure Microcatheter-Based Nonhyperemic Pressure Ratio (SUPREME II Study). (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/finerenone-boosts-hfpef-quality-of-life-03-14-26/ Featured Articles Article 1: Heart failure patients with reduced or mildly reduced ejection fraction: baseline characteristics of the low-dose digoxin outcome DECISION trial. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823368 Summary: This report provided the detailed baseline characteristics of patients enrolled in the D.E.C.I.S.I.O.N. trial. It established the specific clinical profile of contemporary heart failure patients with reduced or mildly reduced left ventricular ejection fraction who are receiving low-dose digoxin or placebo. The report positioned these patient characteristics against those observed in previous cardiac glycoside trials such as D.I.G. and D.I.G.I.T. minus H. F., providing a comparative context for future outcome data. The study design, a randomized, double-blind, placebo-controlled outcome trial, demonstrated its focus on evaluating digoxin’s effects in this defined population. Article 2: Finerenone and Quality of Life in Heart Failure: Component-Level Analyses and Clinical Relevance of the Kansas City Cardiomyopathy Questionnaire. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41817207 Summary: Finerenone improved the overall health status of patients with heart failure with mildly reduced or preserved ejection fraction, as measured by the aggregate 23-item Kansas City Cardiomyopathy Questionnaire score. This prespecified analysis from the F.I.N.E.A.R.T.S. minus H. F. trial contextualized these improvements, demonstrating the clinical relevance of K.C.C.Q. changes for both patients and clinicians. The findings enhance the understanding of how finerenone impacts patient quality of life in this specific heart failure population. Article 3: Infective Endocarditis After Arrythmia Device Implantation in Cardiac Surgery Patients. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823269 Summary: This nationwide registry-based study identified the risk of infective endocarditis after cardiac implantable electronic device implantation within 30 days of cardiac surgery. The study established specific risk factors associated with this complication in patients undergoing first-time cardiac surgery in Sweden. Findings demonstrated that patients in this cohort, without previous cardiac implantable electronic devices, experience an increased risk of infective endocarditis. These results highlight the need for vigilance and targeted strategies in this vulnerable patient population. Article 4: Impact of Combined Anticoagulant and Antiplatelet Therapy in Older Patients With Atrial Fibrillation: ANAFIE Subanalysis. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823252 Summary: This A.N.A.F.I.E. subanalysis evaluated the clinical outcomes of combined oral anticoagulant and antiplatelet therapy versus oral anticoagulant monotherapy in patients aged 75 years or older with nonvalvular atrial fibrillation. The study established the differential impact of these two treatment approaches on clinical endpoints in an elderly Japanese cohort. The findings provided crucial comparative data for managing older atrial fibrillation patients, informing decisions about optimal antithrombotic strategies. This prospective multicenter observational study contributes to understanding medication effects in a high-risk population. Article 5: Clinical Validation of a Novel Pressure Microcatheter-Based Nonhyperemic Pressure Ratio (SUPREME II Study). Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823250 Summary: This S.U.P.R.E.M.E. two study introduced and described the constant resistance

Welcome to Cardiology Today – Recorded March 14, 2026. This episode summarizes 5 key cardiology studies on topics like risk stratification and mortality. Key takeaway: Genetic Evidence for GLP1R in Heart Failure. Article Links: Article 1: Great debate: the new risk factor-weighted clinical likelihood model is useful to estimate the initial pre-test probability of obstructive coronary artery disease in individuals with suspected chronic coronary syndromes. (European heart journal) Article 2: Cardiac amyloidosis across the spectrum of left ventricular function: multimodal functional and prognostic insights. (Heart (British Cardiac Society)) Article 3: Genetic Evidence for GLP1R Agonists in Non-Ischaemic Heart Failure. (ESC heart failure) Article 4: Left-sided heart failure determines outcomes in patients with severe tricuspid regurgitation undergoing percutaneous repair. (European journal of heart failure) Article 5: Prevalence and influence of cardiovascular kidney metabolic syndrome on outcomes after transcatheter aortic valve implantation. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/genetic-evidence-for-glp1r-in-heart-failure-03-14-26/ Featured Articles Article 1: Great debate: the new risk factor-weighted clinical likelihood model is useful to estimate the initial pre-test probability of obstructive coronary artery disease in individuals with suspected chronic coronary syndromes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823519 Summary: The article presents the utility of the new risk factor-weighted clinical likelihood model for estimating the initial pre-test probability of obstructive coronary artery disease. The 2024 European Society of Cardiology guidelines recommend this risk factor-weighted clinical likelihood model as the initial step for individuals with suspected chronic coronary syndromes. This model combines age, sex, symptom characteristics, five clinical risk factors, and coronary calcification data, when available, to provide a numerical estimate of pre-test probability. Article 2: Cardiac amyloidosis across the spectrum of left ventricular function: multimodal functional and prognostic insights. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41825942 Summary: A study of 2244 patients with cardiac amyloidosis demonstrated that many present with mildly reduced or reduced ejection fraction, not solely preserved ejection fraction as commonly perceived. The cohort included 557 patients with light chain amyloidosis, 392 with hereditary transthyretin amyloidosis, and 1137 with wild-type transthyretin amyloidosis. Recognizing cardiac amyloidosis across this full spectrum of left ventricular function, from preserved to reduced ejection fraction, is crucial for accurate diagnosis and effective risk stratification. Article 3: Genetic Evidence for GLP1R Agonists in Non-Ischaemic Heart Failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41825483 Summary: L. P. 1 R Agonists in Non-Ischaemic Heart Failure. Glucagon-like peptide-one receptor agonists demonstrate existing cardiovascular event reduction in patients with obesity and diabetes, alongside symptomatic and functional benefits in heart failure with preserved ejection fraction. This study employed drug-target Mendelian randomization using genetic variants in the glucagon-like peptide-one receptor locus. The research revealed genetic evidence supporting the efficacy of glucagon-like peptide-one receptor activation in non-ischaemic heart failure. This genetic approach offers insights into mechanisms beyond glycaemic control or weight reduction. Article 4: Left-sided heart failure determines outcomes in patients with severe tricuspid regurgitation undergoing percutaneous repair. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41825486 Summary: This study, using data from the EuroTR registry, found that coexisting left-sided heart failure phenotypes significantly determine outcomes in patients undergoing tricuspid valve transcatheter edge-to-edge repair for severe tricuspid regurgitation. The research stratified patients based on left ventricular ejection fraction into reduced or mildly reduced heart failure (below 50 percent) and preserved ejection fraction (50 percent or greater). This analysis demonstrated the specific impact of these heart failure subtypes on 2-year all-cause mortality following the repair procedure. Article 5: Prevalence and influence of cardiovascular kidney metabolic syndrome on outcomes after transcatheter aortic valve implantation. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823981 Summary: This study investigated the cardiovascular-kidney-metabolic syndrome in patients undergoing transcatheter aortic valve implantation. A retrospective analysis of patients from 2011 to 2024 diagnosed and

Welcome to Cardiology Today – Recorded March 13, 2026. This episode summarizes 5 key cardiology studies on topics like left atrial pressure and left atrial shunting. Key takeaway: H. F. pEF Shunt System: 3-Year Safety & Function. Article Links: Article 1: Off-label underdosing of edoxaban antithrombotic therapy for patients with atrial fibrillation and stable coronary artery disease: findings from the EPIC-CAD trial. (Heart (British Cardiac Society)) Article 2: Analysis and prediction of cardiovascular research hotspots, trends and interdisciplinarity. (Heart (British Cardiac Society)) Article 3: Electrocardiogram abnormalities and cardiovascular risk prediction in older Chinese: the Guangzhou Biobank Cohort Study. (Heart (British Cardiac Society)) Article 4: Atrial fibrillation and the risk of sudden cardiac death: incidence, impact and implications. (Heart (British Cardiac Society)) Article 5: The ALT FLOW Early Feasibility Study 3-year Results Assessing Left Atrial to Coronary Sinus Shunting in HFpEF. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/h-f-pef-shunt-system-3-year-safety-function-03-13-26/ Featured Articles Article 1: Off-label underdosing of edoxaban antithrombotic therapy for patients with atrial fibrillation and stable coronary artery disease: findings from the EPIC-CAD trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40930594 Summary: The EPIC-CAD trial defined specific patient populations with atrial fibrillation and stable coronary artery disease receiving edoxaban antithrombotic therapy. This study investigated the clinical outcomes associated with off-label underdosing of direct oral anticoagulants in this patient cohort. Participants were randomized to either edoxaban monotherapy or a dual antithrombotic therapy regimen combining edoxaban with a single antiplatelet agent. This research therefore characterizes the comparative safety and efficacy of these two distinct antithrombotic strategies. Article 2: Analysis and prediction of cardiovascular research hotspots, trends and interdisciplinarity. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40877031 Summary: This study systematically analyzed over 2 million 512 445 cardiovascular publications to characterize research topics, trends, and interdisciplinarity. Artificial intelligence techniques, including natural language processing, were extensively utilized to extract and cluster text fragments from titles and abstracts. This comprehensive data processing approach provides a foundation for clarifying recent cardiovascular research directions and informs policy development for the academic community. Article 3: Electrocardiogram abnormalities and cardiovascular risk prediction in older Chinese: the Guangzhou Biobank Cohort Study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40866119 Summary: This study characterized electrocardiogram abnormalities in 26846 Chinese individuals aged 50 and older from the Guangzhou Biobank Cohort Study. Participants had no cardiovascular disease at baseline. Minor and major electrocardiogram abnormalities were classified based on the Minnesota Code Manual, allowing for definitive categorization of severity. Severity was specifically defined as normal, one minor, two or more minor, or major. Article 4: Atrial fibrillation and the risk of sudden cardiac death: incidence, impact and implications. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40664496 Summary: This study performed a retrospective assessment of sudden cardiac death incidence in patients with atrial fibrillation over an 11-year period, from 2007 to 2018. The analysis included individuals undergoing coronary angiography, specifically those with suspected or known coronary artery disease referred for elective angiography. The study also encompassed patients presenting with acute coronary syndrome, characterizing the long-term sudden cardiac death risk within these specific patient cohorts. Article 5: The ALT FLOW Early Feasibility Study 3-year Results Assessing Left Atrial to Coronary Sinus Shunting in HFpEF. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41814577 Summary: The ALT-FLOW Early Feasibility Study assessed device safety, patency, and echocardiographic parameters over three years in patients with heart failure with preserved ejection fraction. The study specifically evaluated symptoms, health status, and exercise capacity in 95 patients who had a left ventricular ejection fraction greater than 40 percent. This research therefore characterizes the long-term performance of the A. P. T. U. R. E. transcatheter shunt system for left atrial to coronary sinus shunting. Transcript Today’s date is March 13, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Off-label underdo

Welcome to Cardiology Today – Recorded March 12, 2026. This episode summarizes 5 key cardiology studies on topics like advanced heart failure and implanted defibrillators. Key takeaway: Target-Dose A. C. E. I. s Cut Kidney Failure in H. F. rEF.. Article Links: Article 1: Long-term outcomes of patients implanted with a HeartMate 3 left ventricular assist device – a real-world, single center, observational study. (ESC heart failure) Article 2: Effects of Metabolic Syndrome on Cardiovascular Outcomes in Non-Obese Heart Failure Patients. (ESC heart failure) Article 3: Optimised murine HFpEF models for translational pre-clinical studies. (ESC heart failure) Article 4: Are β-Blockers Necessary for Patients with Heart Failure with Preserved Ejection Fraction? : PurSuit-HFpEF Registry. (European journal of heart failure) Article 5: Target-Dose Versus Below-Target-Dose ACE Inhibitors and Lower Risk of Kidney Failure in U.S. Veterans with HFrEF. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/target-dose-a-c-e-i-s-cut-kidney-failure-in-h-f-ref-03-12-26/ Featured Articles Article 1: Long-term outcomes of patients implanted with a HeartMate 3 left ventricular assist device – a real-world, single center, observational study. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812231 Summary: Left ventricular assist device therapy, particularly with the HeartMate 3, is an established treatment for advanced heart failure with reduced ejection fraction. This real-world study characterized the long-term outcomes of 176 patients receiving a HeartMate 3 device at a single center. The research provided specific findings regarding device survival and major adverse events over time in this patient population. These outcomes are crucial for understanding the durable support offered by the HeartMate 3 in clinical practice. Article 2: Effects of Metabolic Syndrome on Cardiovascular Outcomes in Non-Obese Heart Failure Patients. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812230 Summary: Previous research established an association between metabolic syndrome and adverse heart failure outcomes in patients with implanted defibrillators or cardiac resynchronization therapy. This study investigated the specific role of metabolic syndrome and its components in predicting the risk of heart failure or death in non-obese patients with these devices. It included both obese and non-obese patients from a multicenter registry to analyze these predictive relationships. The findings clarified the impact of metabolic syndrome on cardiovascular outcomes in a previously understudied non-obese heart failure population. Article 3: Optimised murine HFpEF models for translational pre-clinical studies. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812219 Summary: F. pEF models for translational pre-clinical studies. The study successfully optimized murine models for Heart Failure with preserved Ejection Fraction, or H. F. pEF, for improved translational pre-clinical studies. Researchers modified the two-hit model protocol by increasing L-NAME doses from 0.5 grams per liter to 1.75 grams per liter and extending protocol lengths from seven weeks to thirteen weeks. These changes reproduced H. F. pEF in both C57BL/6N and 6J mice, addressing previous limitations regarding sub-strain and sex. The refined three-hit model also included specific modifications, yielding more clinically representative models for H. F. pEF research. Article 4: Are β-Blockers Necessary for Patients with Heart Failure with Preserved Ejection Fraction? : PurSuit-HFpEF Registry. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810505 Summary: F. pEF Registry. The clinical effect of beta-blockers in patients with Heart Failure with preserved Ejection Fraction, or H. F. pEF, has been a subject of controversy. This study investigated how common comorbidities, specifically atrial fibrillation and ischemic heart disease, influence beta-blocker effects on H. F. pEF outcomes. Utilizing the PURSUIT-H. F. pEF registry, patients were divided into groups with or without these comorbidities. The research demonstrated how prognosis differed between beta-blocker users and non-users within these stratified patient populations, offering specific insights into treatment efficacy. Article 5: Target-Dose Versus Below-Target-Dose ACE Inhibitors and Lower Risk of Kidney Failure in U.S. Veterans with HFrEF. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41797492 Summary: C. E. Inhibitors and Lower Risk of Kidney Failure in U.S. Veterans with H. F. rEF. This study found that target-dose angiotensin-converting enzyme inhibitors, or A. C. E. I. s, were associated with a lower risk of kidney failure compared to below-target-dose in U.S. Veterans with Heart Failure with reduced Ejection Fraction.