Episode 46
"How We Age: The Science of Longevity" (Professor Coleen Murphy, Princeton)
November 1, 202336m 33s
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Show Notes
Dr. Coleen Murphy is a prominent aging researcher and author of the upcoming book “How We Age: The Science of Longevity” from Princeton University Press. In this wide-ranging discussion, Coleen provides insights into her motivation for writing this book, key topics covered, and her unique perspective on the field.
Key ideas:
- Addressing ethical concerns about studying aging and longevity
- Defining aging conceptually and how metrics like lifespan vs. healthspan are measured
- Using genetics, transcriptomics and other tools to understand molecular changes in aging
- The prominent role of reproduction and sex differences in aging
- Theories on tradeoffs between reproduction and longevity
- Genetics of aging pathways including insulin/IGF-1, mTOR, and sirtuins
- Cellular processes involved in aging such as mitochondrial dysfunction, epigenetic changes, senescence
- The importance of models like C. elegans and Drosophila in aging research
- Ongoing research and future potential for interventions to increase healthspan
- The challenge of complex science without excessive jargon
- Highlighting critical contributions by women scientists in the field
- Omitting personal lifestyle advice and focusing on evidence-based science
- The rapid pace of advancement in biotech applications of longevity science
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