TWiV 1118: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 infection of hunting dogs, dairy cattle, humans and alpacas before reviewing the recent statistics on SARS-CoV-2 infection, risks factors associated with the development of severe COVID-19 in pediatric patients, virus transmission on commercial airline flights, the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database, absence of durability of XBB.1.15 vaccine induced immunity and continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and discusses why development of long COVID should be included in the development of treatments for acute viral disease, if vaccination effects long COVID, structural impairment of brain during long COVID, how cognitive and respiratory function may be compromised in long COVID. For more information about long COVID-19 listen to TWiV 1088 and for H5N1 in dairy cattle and unpasteurized milk TWiV 1117.

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Links for this episode

• Bird dogs infected with high pathogenic avian flu H5N1(AKC)
• Hunting dogs with antibodiesagainst influenza A (H5N1) (Emerging Infectious Diseases)
• Dairy cattle and 2 humans infected with highly pathogenic avian influenza A (H5N1) (MMWR)
• Daisy, are you reading NEJM: cow's milk infected with highly pathogenic avian influenza A (H5N1)? (NEJM)
• Better yet, listen TWiV 1117: pol dances with RNA to learn if mice can transmit H5N1 to each other
• Alpacasinfected with for highly pathogenic avian influenza A (H5N1) (CIDRAP)
• USDA is now inspecting for highly pathogenic avian influenza A (H5N1) in alpacas in Idaho (USDA APHIS)
• COVID-19 deaths
• COVID-19 national trend
• Risk factors for pediatric critical COVID-19 (JPIDS)
• Kids and their underlying conditions for increased risk for severe COVID-19 (CIDRAP)
• SARS-CoV-2 transmission during airline flights (Environmental Research and Public Health)
• Spring vaccine advice(CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practice slides(CDC)
• Really, durable immune response of XBB.1.5 vaccines against Omicron subvariants (NEJM)
• EUA for pemgarda(FDA)
• Infusion centers near you! (pemgarda.com)
• CDC quarantine guidelines (CDC)
• Early phase of SARS-CoV-2 infection (COVID.gov)
• NIHCOVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelinesfor treatment and management (IDSociety)
• Drug interaction checker (University of Liverpool)
• Molnupiravirsafety and efficiacy (JMV)
• Convalescent plasma recommendations for immunocompromised (IDSociety)
• Updated respiratory virus guidelines (CDC)
• What to do when your healthcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staff shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Post COVID-19 following virus vaccination (Nat Comm)
• Why include long COVID-19 when developing novel treatments for acute disease (JID)
• Cerebral microstructural alterations post COVID-19 cognitive, memory and fatigue (Nat Comm)
• Cognitive impairment prevalence and co-occurrence in children and young adults 12 months after Omicron infection (Brain)
• Persistent static lung hyperinflation and small airway dysfunction in long COVID (Respiratory Research)
• Long COVID evidence based review TWiV shout out
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1118
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]