Episode 12
Lethal Buttock Injection (And Other Toxicities of Illegal Cosmetic Body Fillers)
The Poison Lab · Clinical Toxicology LLC
December 8, 20211h 0m
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Show Notes
In this episode Ryan and Toxo dissect the fascinating underbelly of illegal cosmetic procedures and breakdown the toxicities that arise from them.
Intro
Epidemiology
Recent new stories
Common injection practices
Toxicity
- Infection
- Self explanatory
Filler embolism
- Review 1, Review 2, Review 3
- Filler lodges in pulmonary vasculature->clotting, bleeding, inflammation
- 95% occur within 72 hours
- Primarily respiratory symptoms (cough/hypoxemia)
- Chest x ray ground glass opacity
- Treat with supportive care (oxygen all the way through ECMO) +/- steroids
- Filler Blindness
- CRAO from body filler
- No effective treatment (exception, can use hyaluronidase if filler is hyaluronic acid)
- Inflammatory nodules from prolonged filler exposure
- May occur months to year after injection
- Illegal cosmetic= frequently lipogranuloma due to oil being present in many illegal cosmetic
- Granulomatous hypercalcemia
- Excess calcitriol production from ganuloma causes hyperCA
- Can be extremely delayed (up to 28 years)
- Recurrence up to 45%
- Treat with standard therapies (fluid, bisphosphonate) + steroids and/or ketoconazole to turn down granuloma CYP27B1 calcitriol production
- Some details changed for educational purposes
Music in this episode from pixabay.com
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