EP#504 - Unlocking Longevity with Special Guest: Buck Joffrey MD

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Summary

In this conversation, Dr. Vic Manzo interviews Buck Joffrey about the topic of longevity. Buck shares his journey from being a medical doctor to becoming an entrepreneur in the financial services space and his subsequent interest in longevity science. 

He discusses the theory of loss of information in aging and the importance of the epigenome in gene expression. Buck also talks about the potential of reversing epigenetic age and the use of drugs like rapamycin and NAD precursors. 

He emphasizes the importance of optimizing health through diet, exercise, sleep, and supplements, and the need to address underlying health issues to achieve longevity.

Who is Dr. Buck Joffrey?

A self-described biochemistry/molecular biology geek, Buck Joffrey, MD, graduated with Alpha Omega Alpha honors from Northwestern University’s Feinberg School of Medicine. His post-graduate training and interest in neuroscience initially led him to neurosurgical residency at the University of Michigan before detouring into Otolarngology-Head and Neck Surgery at the University of California, San Francisco. 

After residency, he completed an additional fellowship in Cosmetic Facial Plastic Surgery. Just a few years after training, Buck decided to leave practice to pursue his entrepreneurial interests. He went on to become a serial entrepreneur and is now a highly successful real estate investment manager with over $1 billion assets under management. 

Despite his departure from medicine as a career, Buck’s passion for science and medicine never went away, especially as it relates to the science that was emerging in the field of longevity. After years of personally diving deep into this area, Buck decided to share his interests with the world through this passion project, Sapio with Buck Joffrey.

How to Connect with Dr. Buck?

Facebook: https://www.facebook.com/podcastsapio/ 

Twitter: https://twitter.com/SapioPodcast 

LinkedIn: https://www.linkedin.com/company/98815725 

Instagram: https://www.instagram.com/sapio.podcast/ 

Threads: https://www.threads.net/@sapio.podcast 

TikTok: https://www.tiktok.com/@sapio.podcast 

YouTube: https://www.youtube.com/channel/UC-eHrt8eAzqiK1v_srY5BjQ

Takeaways

• Longevity science is making significant advancements in understanding the aging process and the potential for reversing it.
• The epigenome, which controls gene expression, plays a crucial role in aging. Changes in the epigenome can disrupt gene expression and lead to aging.
• Drugs like rapamycin and NAD precursors show promise in reversing epigenetic age and promoting longevity.
• Optimizing health through diet, exercise, sleep, and supplements is essential for longevity.
• Addressing underlying health issues, such as cardiovascular disease and inflammation, is crucial for increasing health span and longevity.