The Michael J. Fox Foundation Parkinson's Podcast

Finding the right Parkinson’s treatment plan can be a trial-and-error process. The kind of medication, the dosage, the timing and lifestyle factors are all important pieces of the puzzle. In audio from this Third Thursdays Webinar, our expert panel made up of people living with Parkinson’s disease (PD), a movement disorder specialist and a researcher discuss different medication options, practical tips for finding what works best for you and the latest research on emerging treatments.  Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Though existing evidence supports that dysfunction in the clearing of cellular debris plays an important role in the development of Parkinson's disease, many unanswered questions remain regarding the mechanisms of the autophagy-lysosomal pathway involved in this process. In particular, research in the field has been limited by a lack of reliable, quantitative tests for monitoring autophagy-lysosome activity. In this interview, Dr. Zhenyu Yue describes his research investigating the cellular and molecular mechanisms for Parkinson's disease and other neurodegenerative diseases, focusing on their work examining the regulation of the autophagy-lysosomal pathway, potential therapeutic targets, and MJFF-funded research that aims to develop sensitive, robust autophagy-lysosome assays to facilitate the discovery of biomarkers for PD using stem cell-derived neurons and biofluids. Zhenyu is the Aidekman Research Professor in the Department of Neurology and Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. He is also the Director of the Center of Parkinson’s Disease Neurobiology and Director of Basic Research of Movement Disorders at Mount Sinai.Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Research shows mindfulness and meditation can improve some Parkinson’s (PD) symptoms and help people live a better life with the disease, but it can be tricky to put into practice. In this podcast, you’ll hear from people whose lives have been touched by PD and who use mindfulness to reduce symptoms and stress, and from a researcher who is studying how mind-body strategies can be used to treat Parkinson’s. Tune in for practical tips, advice and a guided meditation you can try at home.  You can find links to the resources mentioned in the episode on our website:  michaeljfox.org/podcast/breathing-through-mindfulness-parkinsons-treatment-tool You can also download our free guide on exercise and Parkinson’s disease, which includes tips for incorporating meditation into your daily routine at michaeljfox.org/exerciseguide Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Evidence supports that dysfunction in the homeostasis of iron and other elements likely contributes to the pathophysiological mechanisms of Parkinson's disease, but we have yet to develop suitable elemental biomarkers for use in diagnosing and monitoring the progression of Parkinson's disease. Dr. Paul Lingor discusses his work in this area to identify patterns of bioelements in CSF that could serve as PD biomarkers. Beyond CSF, he is also examining tear fluid as a potential biomarker source that is easier to collect. In addition to work on biomarkers, Paul has been involved in developing and evaluating new treatments for Parkinson's disease. In this episode, he discusses an ongoing phase II clinical trial evaluating the ROCK inhibitor Fasudil, as well as research examining combinations of advanced therapies for people with later-stage Parkinson's disease. Paul is Professor of Neurology at the Technical University of Munich and head of the outpatient clinics for motor neuron disease and co-head of the outpatient clinics for Parkinson’s disease.Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

The decision-making process around deep brain stimulation (DBS) to treat Parkinson’s motor symptoms can be a complex and emotional journey. People often have questions about when – and whether – to have the procedure and what the experience is like, from the months of evaluation pre-surgery to surgery day to life with the device. In audio from this Third Thursdays Webinar, our panel of people living with Parkinson’s disease (PD) and a movement disorder specialist share their DBS stories and answer audience questions about their choices and experiences.   Learn more about deep brain stimulation and download our free guide on our website: https://bit.ly/4cTOT52Like our podcasts? Please consider leaving a rating or review and sharing the series with your community.  The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Identifying reliable biomarkers for the diagnosis and prognosis of Parkinson's disease and atypical parkinsonism would have substantial impacts on clinical trials and clinical practice. A particularly active area of research is the development of novel molecular imaging biomarkers that can be used in combination with common neuroimaging approaches. Dr. Antonio Strafella discusses current practices for using molecular imaging biomarkers in research and in the clinic, the process of developing new biomarkers, as well as promising biomarkers that are in development. He also discusses limitations, implementation challenges, and the potential use of AI to enhance diagnostics in the future. Antonio is the Krembil-Rossy Chair in Molecular Imaging of Neurodegenerative Diseases and Professor in the Department of Medicine within the Division of Neurology at the Toronto Western Hospital (University Health Network, University of Toronto). He also serves as Director of Clinical Research and Translation with the Temerty Faculty of Medicine at the University Toronto, and he is a movement disorder neurologist in the Edmond J. Safra Program in Parkinson’s Disease and Morton & Gloria Shulman Movement Disorders Clinic at the Toronto Western Hospital.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Just over a year ago, there was a major breakthrough in Parkinson’s disease (PD) research – a tool that could detect abnormal alpha-synuclein protein in the spinal fluid of people living with PD even before onset of symptoms. This discovery is already impacting the ways scientists conduct and think about Parkinson’s research. Tune into this episode of our award-winning “Parkinson’s Science POV” series to learn  how researchers are using the test to better understand disease biology and what the future holds.    Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Prior studies have established links between poor olfaction and Parkinson's disease, and impaired sense of smell is a common prodromal symptom of Parkinson's disease. The causes and mechanisms of prodromal neurodegeneration are actively being researched. However, environmental exposure to pesticides or other chemicals may trigger or modify the course of neurodegeneration, potentially leading to the development of Parkinson's disease over time. In this episode, Dr. Honglei Chen shares his research on environmental causes of neurodegenerative diseases, focusing particularly on evidence linking olfaction, environmental exposure, and Parkinson’s disease. Better understanding how environmental factors may contribute (alone or in combination with genetic factors) to the pathogenesis of Parkinson's disease may lead to new approaches to prevent or slow the progression of neurodegeneration. Honglei is the MSU Research Foundation Professor of Epidemiology and Biostatistics at Michigan State University.Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

You might be interested in stepping forward for science to play a role in the next breakthrough in Parkinson’s research, but still have questions about how to actually participate. How do you pick the right study for you? How do you balance your life logistics and your medical care considerations? What rights do you have when you participate in a study? In audio from this Third Thursdays Webinar, our panel of people living with Parkinson’s and research experts discuss the practicalities and benefits of volunteering for research.  Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Gait impairments such as slow speed, small steps, and high variability from step to step are common in people with Parkinson's disease, and these changes begin to occur early in the course of disease. Freezing of gait may develop later for some individuals, and it has been linked to falls and other adverse outcomes. When the quality of walking declines, it can lead to a reduction in the quantity of walking and overall physical activity, which is also related to poorer health outcomes. To prevent this cascade of events, Dr. Gammon Earhart is developing and evaluating interventions to improve gait and increase physical activity in People with Parkinson's disease. In this episode, she discusses how she and collaborators are conducting studies on different approaches, including a mobile health application, self-generated rhythmic cues in the form of singing, and mindfulness training, to improve aspects of walking and physical activity in people with Parkinson's disease. Gammon is Professor of Physical Therapy, Neurology, and Neuroscience, Associate Dean for Physical Therapy, and Director of the Program in Physical Therapy at Washington University School of Medicine in St. Louis.Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Improving our understanding of the complex neural circuits involved in normal function of the basal ganglia and other parts of the brain impacted by Parkinson's disease is critical for developing more targeted and more effective treatment approaches. In this episode, Dr. Aryn Gittis discusses her research examining how the activity of specific basal ganglia circuits relates to motor control in both health and pre-clinical models of movement disorders like Parkinson's disease. She describes new research on basal ganglia circuits that expands upon existing theoretical frameworks and provides important insights that can be leveraged to improve current therapies for Parkinson's disease by better targeting specific cell types in relevant circuits. Aryn also shares details about her ongoing project evaluating the impacts of stimulus location for a novel pattern of deep brain stimulation (DBS) that has been shown to provide long-lasting therapeutic effects in pre-clinical models. Aryn is Professor of Biological Sciences and the Neuroscience Institute at Carnegie Mellon University.Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Many people living with Parkinson’s disease (PD) experience pain as a non-motor symptom. Pain can arise from stiff muscles, dystonia, nerve pain and even the disease progression itself. It’s a symptom that some find difficult to talk about, but there are options for people to find relief. In audio from this Third Thursdays webinar, listen to our expert panel of people living with PD, movement disorder specialists, and an integrative pain specialist discuss pain and Parkinson’s – why it happens, treatments to reduce it, and practical tips you can start incorporating today.  Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Demand for movement disorder specialists continues to grow, but not enough neurologists are receiving focused training in Parkinson’s and related conditions in order to meet the current and projected needs in the U.S. and around the world. In collaboration with longtime partner the Edmond J. Safra Foundation, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders with the goal of growing the global base of movement disorders specialists. In this episode Dr. Rachel Dolhun shares more about this fellowship program, the application process, and how the program supports the training of movement disorders clinician-researchers who will become leaders in Parkinson's care and advance science in the field. Rachel is Senior Vice President of Medical Communications at The Michael J. Fox Foundation for Parkinson's Research. Visit michaeljfox.org/funding to learn more about the Edmond J. Safra Fellowship in Movement Disorders. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

In this episode, hosted by Larry and Rebecca Gifford, members of The Michael J. Fox Foundation’s Patient Council and their care partners share their honest reactions to their diagnosis — from panic and denial to sadness and loneliness. This group of men and women of different ages and backgrounds offers words of wisdom about what to consider, what they’ve lost and what they’ve gained – and you’ll be surprised to hear how, for some, what they’ve gained is more than what they lost. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  If you or a loved one was recently diagnosed and you’re wondering where to start, visit https://www.michaeljfox.org/newlydiagnosed to find helpful resources, including an educational guide, support groups and videos. Whether you’ve been newly diagnosed or have been living with Parkinson’s for many years, The Michael J. Fox Foundation’s Parkinson’s Buddy Network is a free, online platform that helps you find new connections, access educational resources and engage in important dialogue. Join our community today at parkinsonsbuddynetwork.org.  The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

In this raw and emotional conversation, four women with Parkinson’s living in four different countries discuss the challenges faced because of delayed diagnosis, hormonal changes, lack of information and treatment, research inequity and gender biases. They share how they live better with the disease by advocating for themselves with their health care team and how they empower other women through awareness and activism. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  Connect with other women who share your experiences with Parkinson’s. The Michael J. Fox Foundation’s Parkinson’s Buddy Network is a free, online platform that helps you find new connections, access educational resources and engage in important dialogue. Join our community today at parkinsonsbuddynetwork.org. The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Trichloroethylene (TCE) and related chemicals like perchloroethylene (PCE) have been used widely for a variety of commercial purposes over the past century, and these chemicals are prevalent in the air, water, and soil. Over the past several decades, mounting evidence has been published linking exposure to TCE/PCE with adverse health effects, including cancer and Parkinson's disease. In this episode, Dr. Sam Goldman discusses his research on environmental risk factors for Parkinson’s disease, focusing on recently published studies examining Parkinson's disease risk in Veterans at Camp Lejeune and also a cluster analysis investigating parkinson's disease diagnoses in people who worked near a contaminated site. Sam is a Professor in the Division of Occupational, Environmental, and Climate Medicine and the Departments of Medicine and Neurology at the University of California, San Francisco (UCSF). He is also a Principal Investigator in the San Francisco Veterans Affairs Medical Center.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Living with Parkinson’s comes with a variety of symptoms, some of which can be unexpected, and frankly, embarrassing. Drooling, bladder issues and sexual dysfunction are hard to talk about, even with loved ones or your doctor – and can affect your self-image,  your intimate relationships or the way you move through the world.  In audio from this Third Thursdays webinar, listen to our expert panel of people living with Parkinson’s, a care partner and a movement disorder specialist discuss Parkinson’s taboo topics and ways that you can navigate hard conversations and embarrassment.  Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Whether you’ve been newly diagnosed or have been living with Parkinson’s for many years, The Michael J. Fox Foundation’s Parkinson’s Buddy Network is a free, online platform that helps you find new connections, access educational resources and engage in important dialogue. Join our community today at parkinsonsbuddynetwork.org.  The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

For over a century, different surgical interventions have been explored to address symptoms of Parkinson's disease, and researchers are continuing to innovate and improve surgical treatments today. With new technology and an ever-expanding understanding of the function of the nervous system and the pathophysiology of Parkinson's disease, neurosurgical interventions are becoming more effective and more personalized. Dr. Doris Wang joins us in this episode to discuss her work using focused ultrasound and deep brain stimulation (DBS) as treatments for Parkinson’s disease and other movement disorders. She discusses some of the benefits and limitations of focused ultrasound treatment, comparisons of traditional versus asleep interventional MRI-guided deep brain stimulation surgery, advances in adaptive deep brain stimulation, and the development of gait-related biomarkers that could drive adaptive DBS. Doris is a neurosurgeon and Associate Professor in the Department of Neurological Surgery at the University of California, San Francisco (UCSF). Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

The Michael J. Fox Foundation for Parkinson's Research established its Research Tools Program to address gaps in the field and common challenges surrounding the development of reagents and models that slowed the initial stages of promising research projects. In collaboration with many partners and stakeholders, the Research Tools Program helps ensure that scientists around the world have access to high-quality reagents, models, and more. These tools have been instrumental in launching novel research projects to better understand Parkinson's disease and to develop promising new treatment strategies. This episode features Dr. Nicole K. Polinski, Director of Research Resources at The Michael J. Fox Foundation for Parkinson’s Research. In our conversation, she discusses her role in the organization, the wide variety of tools available through the Research Tools Program, and how academic and industry researchers can share their insights and feedback on current tools and future directions for tool development.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

The biology behind what causes Parkinson’s is complex, with only about a quarter of cases with clear genetic drivers. The environment – where you live, the air you breathe, the food you eat, the world around you – plays a key role in PD. Emerging research is showing environmental exposures to things like pesticides and pollution may interact with a person’s genetics and contribute to the disease. And there’s a myriad of other factors still being investigated, from the forces that drive your access to neighborhoods with clean air and water, good doctors and healthy living opportunities to psychosocial factors like stress and discrimination. In audio from this Third Thursdays Webinar, listen to our expert panel discuss the latest research and ways you can get involved to end preventable exposures and advocate for Parkinson’s policy.  Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Increasing evidence supports the presence of sex and gender differences in neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease. There is a critical need to more closely examine sex and gender differences in all stages of research, therapeutic development, and clinical treatment to enable better outcomes through precision medicine approaches. This episode focuses on the relevance of sex and gender factors in Parkinson's disease and efforts to transform scientific research, policy, and healthcare to identify and address needs based on sex and gender. Our guest Dr. Antonella Santuccione Chadha discusses her work with the Women’s Brain Project, their recent roundtable on enhancing care in Parkinson’s disease, and the organization's goals for the future. Antonella is a medical doctor with experience spanning positions in clinical care, academic research, the Swiss Agency for Therapeutic Products (regulatory), and industry leadership and consultation for large pharmaceutical companies and smaller start-up companies. She is currently Co-Founder and Pro Bono Chief Executive Officer of the Women’s Brain Project, an international non-profit organization studying sex and gender determinants to brain and mental health.Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Atypical Parkinsonian Syndromes, such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies are often initially diagnosed as Parkinson's disease. Incorrect, incomplete, or delayed diagnoses are barriers to beginning the most appropriate treatment early in the disease course. More research is needed to facilitate early diagnoses, understanding of disease pathogenesis, and monitoring of disease progression. However, largescale, collaborative initiatives are making meaningful progress in understanding genetic contributors to disease pathology and progression in Parkinson's disease. Our guest in this episode, Dr. Huw Morris, has spent more than twenty five years researching Parkinson's disease and parkinsonian syndromes, and he shares highlights from recent work, including studies on the genetics and pathogenesis of Parkinson’s disease and other parkinsonian syndromes. Huw is Professor of Clinical Neuroscience at University College London Institute of Neurology, as well as an Honorary Consultant Neurologist at the Royal Free Hospital and the National Hospital for Neurology and Neurosurgery Queen Square. Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

The drug development pipeline is key to bringing new therapies to people with Parkinson’s disease (PD). With major breakthroughs in research in the past year, including a new biomarker for PD, The Michael J. Fox Foundation’s Parkinson’s Progression Markers Initiative (PPMI) study and other initiatives can be leveraged to create better designed trials. This audio from our Third Thursdays Webinar features a conversation about all the ways clinical trial design is changing, and why leaders in the space believe those changes will lead to better treatments. The webinar includes contributions from a person with PD, a researcher and an industry leader.     Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0   Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

For many years, Parkinson's disease and dementia with Lewy bodies have been defined using clinical features. With recent advances in biomarkers, particularly the alpha-synuclein seed amplification assay that allows us to detect misfolded and aggregated alpha-synuclein in cerebrospinal fluid, it is now possible to identify the presence of pathological neuronal alpha-synuclein in living patients. With input from diverse stakeholders, a new biological definition of neuronal alpha-synuclein disease (NSD) has been proposed, along with an integrated staging system (NSD-ISS). In this interview, we discuss the development of this biologic definition for Parkinson’s disease and the staging system with Dr. Lana Chanine, one of the lead authors of the recently published manuscript in The Lancet Neurology that describes this work. It is important to note that the NSD and NSD-ISS are for research purposes only right now, and they are not ready to be implemented in the clinic. Lana is a Movement Disorders Neurologist and Associate Professor of Neurology at the University of Pittsburgh.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Dating and beginning new relationships with Parkinson’s involve distinct challenges, joys and fears. In this frank and funny podcast, our experts discuss how they face considerations like building and maintaining confidence, disease disclosure, and the importance of self-knowledge and self-care in new relationships. They remind us all that no matter what we’re facing, dating and finding love can be fun and fulfilling. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  Whether you’ve been newly diagnosed or have been living with Parkinson’s for many years, The Michael J. Fox Foundation’s Parkinson’s Buddy Network is a free, online platform that helps you find new connections, access educational resources and engage in important dialogue. Join our community today at parkinsonsbuddynetwork.org. The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

There is a pressing need to develop safe and effective disease-modifying and symptomatic treatments for Parkinson's disease. Through improvements in our understanding of the pathophysiology of the disease, as well as genetic risk factors, new potential treatment targets have emerged. However, bringing a promising new compound from the lab through all of the steps of drug development is a long, difficult, and resource-intensive process. In recent years, collaborative efforts and advances in biomarkers have led to important breakthroughs that have the potential to facilitate the development of new drugs for Parkinson's disease. In this episode, Dr. Kalpana Merchant draws from over two decades of pharmaceutical industry experience to share progress in drug discovery and development for Parkinson’s disease and other neurodegenerative conditions. Kalpana is President and Chief Scientific Officer at TransThera Consulting, which provides guidance on drug discovery and translational strategies to biopharma startup companies. She is also an Adjunct Professor at Northwestern University’s Feinberg School of Medicine, a member of the Oregon Innovation Council, a Scientific Advisor at The Michael J. Fox Foundation, and she serves on advisory panels at the National Institutes of Health.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

We know exercise is important for people with Parkinson’s. Once you’ve decided to move more, what next? In this audio from our Third Thursdays Webinar, our experts discuss strategies for making exercise a meaningful part of your life. They present ways to make time for exercise and to make the most of it, including being aware of different types, frequencies and intensities. This discussion will help you find a way to get moving and stay motivated. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  Join a Foundation-hosted run/walk event. Or register for the Unity Walk. Every mile moves us one step closer to a cure for Parkinson's. Learn more at michaeljfox.org. Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.  Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

One key pillar of The Michael J. Fox Foundation’s research strategy is a focus on “de-risking" potential treatments for Parkinson’s disease. This episode of our award-winning “Parkinson’s Science POV” series explains how lowering the risk associated with developing new therapies leads to a more robust pipeline of treatments. The episode details several recent successes of the strategy. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Join a study today to help speed progress toward better treatments and a cure for Parkinson’s disease. To search for studies in your area, visit Fox Trial Finder at foxtrialfinder.org. Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

In neurodegenerative conditions such as Parkinson's disease (PD), patients often do not receive a diagnosis until the hallmark motor symptoms begin to manifest. This can be a decade or more after substantial changes start occurring in the brain. A major goal of the PD research field has been to develop methods for earlier detection and intervention. Over the years, there have been substantial advances in neuroimaging techniques and biological biomarkers that have allowed us to more accurately identify patients with Parkinson's disease, including the recent development of the alpha-synuclein seed amplification assay. In this episode, Dr. John Seibyl discusses his early work on neuroimaging in Parkinson's disease through to the groundbreaking, large-scale clinical trials he is involved with for assessing the impacts of neuroprotective drugs for Parkinson's disease as well as Alzheimer's disease. He also shares his perspectives as a researcher and a patient with Parkinson's disease. John is Chairman of the Board, Co-Founder, and Senior Scientist of the Institute for Neurodegenerative Disorders in New Haven, Connecticut. He is also a board-certified physician in both Psychiatry and Nuclear Medicine, and he is an Adjunct faculty member in Neurology at Yale University School of Medicine.Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Doctors have been using DaTscan brain imaging as a tool to help diagnose the Parkinson’s disease (PD) for more than a decade, but even people who know a lot about the disease often still have questions about its role — and the role of other imaging tools — in diagnosis and care. What’s a DaTscan, and how does it relate to PET, SPECT and MRI? When is a DaTscan or other brain imaging tool used in PD? Are there any risks? In this audio from our Third Thursdays Webinar, experts and people with PD offer listeners an impromptu course in Brain Imaging 101. You’ll learn to differentiate the different types of imaging used to visualize the brain and how they are used in PD research and care. You’ll also learn the latest in efforts to visualize alpha-synuclein, the protein that misfolds and clumps in Parkinson’s, and what its selective imaging in the living brain will mean for PD clinical trials and care. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

A substantial portion of people with Parkinson's disease (PD) have a family history of the disease, and new findings continue to improve our understanding of relevant genetic variants. These discoveries are key for clarifying the mechanisms that lead to Parkinson's disease as well as the development of new therapies. The Global Parkinson's Genetics Program (GP2) was established to gather and integrate genetic and clinical data from diverse participants around the world to expand our knowledge of the genetic architecture of PD. In this episode, Dr. Christine Klein discusses her experiences as Co-Leader of the Monogenetic Network of GP2, including the early days of setting up this large-scale collaboration, important achievements to date, and priorities and considerations going forward. She also shares recent findings from her own research on genetic variants related to Parkinson's disease. Christine is Director of the Institute of Neurogenetics and of the Section of Clinical and Molecular Neurogenetics at the Department of Neurology, as well as the Schilling Professor of Neurology at the University of Lübeck in Germany. She is also Co-Director of the Monogenetic Network of GP2. Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

The holidays can be a time of joyful celebration with those we love. They may also come with the stress of travel, disruptions to your regular routine or even loneliness.  For those living with Parkinson’s disease (PD), or those taking care of someone they love with the disease, these feelings can be intensified. This podcast offers tips to people living with PD, as well as their care partners, friends and family, for how to prepare — mind, body and suitcase — to make your holidays happy.  Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

A growing body of evidence is expanding our understanding of the links between inflammation, our immune responses, brain health, and neurodegeneration. In particular, several genes associated with Parkinson's (including LRRK2) are known to be involved in inflammation, and peripheral inflammation has been shown to influence brain function and contribute to the development of neurodegenerative diseases. Better understanding the roles of inflammation and our immune responses in Parkinson's disease is important for developing new treatments and strategies to slow or prevent disease progression. In this episode, Dr. Malú Gámez Tansey talks about her research at the intersection of immunology, neuroscience, and genetics. She describes new findings and current projects in her lab, discusses advances in neuroimmunology, and shares her insights on important areas of opportunity in the field. Malú is the Norman and Susan Fixel Chair in Parkinson's Disease, Professor of Neuroscience and Neurology, and Director of the Parkinson's Foundation Research Center of Excellence at the University of Florida College of Medicine. She's also editor-in-chief of Nature Partner Journal Parkinson's Disease.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Mutations in the LRRK2 gene were first linked to Parkinson's disease (PD) risk in 2004. Since then, researchers from around the world have advanced our understanding of the mechanisms through which LRRK2 may contribute to PD, leading to the development of three potential LRRK2-targeted therapies that are now being evaluated in clinical trials. Along with colleagues and collaborators, Dr. Dario Alessi has pioneered new research and approaches that have aided in the development of drugs to inhibit LRRK2 and potentially treat people with Parkinson's disease. In this episode Dario discusses his work developing the LRRK2 kinase assay, LRRK2 Ser935 dephosphorylation assay, and Rab phosphorylation assay, as well as future directions and opportunities in the field. This year, Dario received the 2023 Robert A. Pritzker Prize for Leadership in Parkinson’s Research for his substantial research contribution and his commitment to mentoring the next generation of Parkinson’s scientists. Dario is the Professor of Signal Transduction and Science Director of the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

In a year of remarkable progress for the Parkinson’s field, we’re entering a new era for better understanding the biology of the disease, with the identification of a breakthrough biomarker accelerating new therapeutics through the clinical pipeline and legislators on Capitol Hill moving toward legislation that unites the federal government on a mission to treat, prevent and cure Parkinson’s disease. What does this progress mean for researchers studying Parkinson’s and for those living with the disease? And what will come next? Tune in as scientists and staff from The Michael J. Fox Foundation (MJFF) answer these questions and share insights in our latest Third Thursdays Webinar. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  Join a study today to help speed progress toward better treatments and a cure for Parkinson’s disease. To search for studies in your area, visit Fox Trial Finder at foxtrialfinder.org.  Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

For decades, researchers, clinicians, and industry professionals have continued to study and optimize deep brain stimulation (DBS) with the goal of providing the best possible personalized treatment for Parkinson’s disease (PD) and other neurological conditions. In this episode, Dr. Michael Okun joins us to discuss his research and some of the recent advances in deep brain stimulation and other areas. He draws from his extensive research and clinical experience applying DBS and neuromodulation therapies for patients with PD, Tourette syndrome, tic disorders, dystonia, essential tremor, and obsessive-compulsive disorder. Michael is co-founder and co-director of the Norman Fixel Institute for Neurological Diseases at the University of Florida, as well as Medical Advisor for the Parkinson’s Foundation. He is a board-certified neurologist, movement disorders specialist, neuroscientist, author, and an expert on deep brain stimulation and neuromodulation for movement disorders. Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

In a groundbreaking discovery earlier this year, a global consortium found a new variant in the GBA gene that is associated with a higher risk of Parkinson’s disease (PD) for people of African ancestry. The finding marks the first African ancestry-specific genetic risk factor for Parkinson’s disease. In this podcast, researchers share the human stories behind the discovery, which underscores the importance of international collaboration and the participation of underrepresented communities in research.  Themes covered in this discussion: (02:05) – Breaking down the genetic discovery and why it’s important for PD research (05:27) ­– More on the genetic samples that resulted in this discovery (06:53) –Why the GBA1 gene is of interest and its connection to PD (11:13) – How the Global Parkinson’s Genetics Program (GP2) maintains privacy and confidentiality of data from study participants (13:15) – How people should think about genetics as a risk factor for PD (14:55) – Capacity building and building community trust (19:57) –Why this discovery takes us closer to finding better treatments and a cure for PD (21:51) – Story behind accidental discovery of GBA1 variant (22:50) – Background on GP2 and excitement on the GBA1 variant discovery (33:17) – Ethnicity and health risk factors and other determinants of health (35:03) – Importance of diversity, equity and inclusion in science and to The Michael J. Fox Foundation’s mission (36:52) – Research in PD historically focused on people of Northern European ancestry  (38:09) –Why people from underrepresented groups need to lead these studies (39:30) – Importance of including underrepresented populations across the research pipeline (40:18) –Why research participation is important and how you can get involved Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Sleep impacts our lives in many different ways, and Dr. Amy Amara joins us in this episode to discuss her career and findings from her research on sleep in Parkinson’s disease (PD). She shares her insights on the characteristics of sleep in people with Parkinson’s disease, how sleep can be impacted by exercise, medications, and deep brain stimulation, and how studying rapid eye movement (REM) sleep behavior disorder may be important for developing early treatments before PD motor symptoms manifest. Amy is a Professor of Neurology at CU Anschutz School of Medicine who is an expert on quantitative electroencephalography, sleep disorders, and neurodegenerative disease. This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

People with Parkinson’s disease (PD) have lots of questions about probiotics, prebiotics, laxatives and fiber. That’s because constipation and bloating are some of the more bothersome but less talked about symptoms of PD. In this audio from our Third Thursdays Webinar, experts and people with PD discuss effective ways for managing constipation and other gut-related symptoms. You’ll also learn about emerging treatments for constipation, the gut-brain connection and why the gut is linked to Parkinson’s. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

In this episode, serial entrepreneur Dr. Karoly Nikolich shares his perspectives on the industry side of the state of neuroscience, as well as areas of opportunity and the role of industry in advancing the field. He also discusses recent major breakthroughs, the importance of industry partnerships, including collaborations with The Michael J. Fox Foundation (MJFF), and how he is working to advance Parkinson's disease research through his work at Alkahest and other endeavors. Karoly is a scientific advisor at Bayshore Global Management and at Pivotal Bioventures. In addition, he is Chairman and Executive Advisor at Alkahest Inc., and also an Adjunct Professor of Psychiatry at Stanford University. Karoly has extensive expertise in the biotech and neuro-therapeutics industries, and he also manages his foundation, the Scholar Nikolich Foundation. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

New research advances are expanding our knowledge of Parkinson's disease and bringing us closer to the ultimate goals of new treatments, effective cures, and disease prevention. In this introductory episode, you'll hear from Dr. Brian Fiske and Dr. Mark Frasier, Co-Chief Scientific Officers at The Michael J. Fox Foundation for Parkinson's Research (MJFF). During the conversation, they provide their perspectives on the state of the field of Parkinson's disease research, describe new advances in biomarkers for Parkinson's disease, and discuss progress in the development of novel therapeutics. They also share insights on resources and tools being developed to advance Parkinson's research, MJFF's research strategy, and what it could mean for your research.Mentioned in this episode:This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Shock, doubt, anxiety — a diagnosis of Parkinson’s can trigger these and many other difficult emotions. This replay of audio from our Third Thursdays Webinar features a conversation among people with Parkinson’s about how they processed the emotional aftermath and navigated the early years following their diagnosis. We also hear from a psychologist who specializes in Parkinson’s about what she’s learned about how people deal with this life-changing diagnosis and ways to manage the emotions in a positive way. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

In this replay of audio from our Third Thursdays Webinar, Michael J. Fox Foundation Patient Council member Larry Gifford leads a discussion on common Parkinson’s issues — dyskinesia and "off" time — and how to treat them. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Stem cells have grabbed headlines for decades. Now, at last, they are starting to deliver on their therapeutic promise, with multiple stem cell therapies in clinical trials for Parkinson’s disease. This episode of our award-winning “Parkinson’s Science POV” series brings us up to date on these trials, including how scientists are using stem cells to replace dopamine, the chemical that’s lost in Parkinson's disease. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Join a study today to help speed progress toward better treatments and a cure for Parkinson’s disease. To search for studies in your area, visit Fox Trial Finder at foxtrialfinder.org. Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.com/podcast-ppmi. Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

How’s this for a dinnertime conversation starter… did you know that what happens in your gut can have an impact on your brain health? Some experts even call the gut “the second brain” because of its huge community of microbes and large nerve network that links the gut to brain disease, like Parkinson’s. Join our panel of experts who cover the latest research on this link between gut and brain health. And tune in as they discuss common gut symptoms of Parkinson’s and what you can do to manage them. For more on this topic, visit michaeljfox.org/guthealth. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Many people with Parkinson’s experience autonomic symptoms, like bladder problems, low blood pressure and constipation that can be hard to talk about. In this audio from our Third Thursdays Webinar replay, experts and patients open a dialogue on these issues and share ways to treat them. Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.com/podcast-ppmi Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

In the latest installment of our award-winning “Parkinson’s Science POV” series, MJFF’s Maggie Kuhl sits down with Mark Frasier and Brian Fiske, Chief Science Officers at MJFF, in an “Ask MJFF Anything” edition of our podcast. These experts cover a variety of questions from our community about Parkinson’s disease (PD) therapies and treatments, the recent biomarker breakthrough and more. Get answers on topics ranging from how exercise helps improve balance, to what the new biomarker breakthrough means for the Parkinson’s community. Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.com/podcast-ppmi Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Have you ever wondered what’s the best exercise for your brain? Listen as our expert panel breaks down approachable tips to add more movement into your day-to-day, Parkinson’s-friendly exercises to try right now and the science behind the benefits of working up a sweat. Join hundreds of Parkinson’s community members June 17 weekend for our annual Virtual Run/Walk. Register and learn more at www.michaeljfox.org/runwalk Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

Faith and science are not often discussed together, but science requires a leap of faith. A few years ago, MJFF staff scientists, Samantha Hutten, PhD and Katie Kopil, PhD never would have guessed that a leap of faith and a cold call to a researcher in Texas would lead to a tool that, for the first time, can detect Parkinson’s in people who have not yet shown symptoms. With the help of the countless community members taking part in the PPMI study, these researchers found a biomarker for Parkinson’s. Hear all about the journey to the breakthrough and what it means to the Parkinson’s community in this rich discussion with some of the humans behind it. Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. michaeljfox.org/podcast-ppmi Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3

In April, The Michael J. Fox Foundation (MJFF) announced a major biomarker breakthrough, opening a new chapter for Parkinson’s research — with the promise of better drug development and care for all people and families living with the disease. With the new test, validated by MJFF’s Parkinson’s Progression Markers Initiative (PPMI), researchers can objectively define and monitor this pathology for the first time in the living body. Experts explain the promise this research holds for all people living with Parkinson’s. PPMI is enrolling people with and without Parkinson's disease. Join the study that's changing everything. michaeljfox.org/podcast-ppmi Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Mentioned in this episode:April is Parkinson’s Awareness Month, and it comes with a chance for you to make a real difference. For people living with Parkinson’s and their loved ones, progress can’t wait — every new discovery, every step forward in research and every bit of your support matters. Visit our website to learn how you can get involved. http://bit.ly/48bPdM3