Episode 31 - The Clinician’s Guide to Ketamine Therapy: History, Science & Real-World Protocols
Understand the evolution, mechanisms, and clinical use of ketamine therapy for depression, PTSD, anxiety, and chronic pain—with protocols, science, and real-world insights for medical professionals.
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Show Notes
In this episode, Sam presents a comprehensive overview of ketamine therapy from a clinical lens. Originally delivered as a lecture titled “Exploring Ketamine IV Infusions: A Novel Approach for Depression, PTSD, Anxiety, & Chronic Pain” to the UCLA–Betty Ford Addiction Medicine Fellowship, this session walks through everything from the mental health crisis to ketamine’s evolving role in modern treatment.
Whether you’re a curious clinician or an experienced provider, this is your go-to primer on how ketamine therapy works—and why it matters now more than ever. With over 50 years of clinical use and a growing body of scientific research, ketamine is proving to be a powerful option for treatment-resistant depression, PTSD, anxiety, and chronic pain.
Sam brings together the science, protocols, and personal insights from running a real-world ketamine clinic to help demystify the treatment process and spark deeper understanding among medical professionals.
What You’ll Gain From This Episode:
・A deeper understanding of how ketamine works in the brain
・Knowledge of current research and studies supporting ketamine’s use
・Insights into patient selection, safety, and personalized dosing strategies
Episode 31 show notes:
00:00 Teaser - Depression is the leading cause of disability worldwide.
00:30 Welcome and Episode Overview
01:17 Ketamine Infusions: A Novel Approach
02:17 Current State of Mental Health and Ketamine History
09:36 Mechanisms of Action and Scientific Studies
12:11 Patient Experiences and Clinical Applications
23:22 Ideal Patient Selection and Dosing Protocols
29:10 Potential Side Effects and Addiction Risks
33:21 Conclusion and Final Thoughts
Thanks for listening
For references and studies mentioned in this episode, go to www.ketaminestartup.com/podcast/episode-031
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