Episode 30
E29: CIRT and CANTOS - Immunotherapy for Cardiovascular Disease
The Evidence Based Rheumatology Podcast
November 21, 201819m 58s
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Show Notes
Double episode this week and then I'll be taking the holidays off. I decided to combine two trials of immunotherapy for secondary prevention of cardiovascular disease, the CANTOS trial (canakinumab vs. placebo) and the CIRT trial (methotrexate vs. placebo). It was a good opportunity to debunk both therapies and take a few pot shots at observational trials, "bioplausibility," and surrogate endpoints. Both papers are available on my box account here.