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The Cellular ‘Danger Mode’ Keeping You Sick (And How to Escape It)
Season 1 · Episode 254

The Cellular ‘Danger Mode’ Keeping You Sick (And How to Escape It)

What if your fatigue, brain fog, or chronic symptoms aren’t because your body is broken, but because it’s stuck in defense mode?

The Dr. Josh Axe Show

May 27, 202538m 3s

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Show Notes

What if your fatigue, brain fog, or chronic symptoms aren’t a malfunction—but a misunderstood survival mechanism?

In this episode, you'll learn...

  • What the Cell Danger Response is and why it's triggered by infection, trauma, or toxins.

  • Why your body might be stuck in survival mode—and how that explains persistent fatigue, pain, or brain fog.

  • How mitochondria signal danger and what it means when ATP becomes an alarm.

  • The three phases of CDR: Defense, Repair, and Reintegration—and what it takes to move forward.

  • How healing involves safety, not force: through trauma work, detox, red light therapy, and mitochondrial support.

  • A hopeful framework for chronic illness that connects the dots between autoimmune disease, long COVID, autism, and more

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0:00 Introduction

1:15 Cell Danger Response

2:48 ATP Release Issues

5:38 Phase 1: Danger Detection

8:07 Phase 2: Cell Defense

9:10 Phase 3: Recovery & Healing

9:55 Job of Mitochondria

11:10 Biggest Symptoms of CDR

13:10 Common Conditions Linked to CDR

16:52 Bloodwork Ad

18:12 Steps to Healing from CDR

35:10 Outro

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Links: 

https://aonm.org/wp-content/uploads/2021/07/Cell-Danger-Response-IHCAN.pdf

https://www.youtube.com/watch?v=u028TAyB9S4

https://pmc.ncbi.nlm.nih.gov/articles/PMC10427836/

https://pmc.ncbi.nlm.nih.gov/articles/PMC6627909/

https://tacanow.org/family-resources/medical-article-common-medical-issues/the-cell-danger-response-in-autism/

https://www.sciencedirect.com/science/article/pii/S1567724919302922

https://www.sciencedirect.com/science/article/pii/S1567724918301053

https://www.sciencedirect.com/science/article/pii/S1567724913002390

https://www.sciencedirect.com/science/article/abs/pii/S0028390815002129

https://watermark.silverchair.com/gkv1003.pdf

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30428-X

https://www.sciencedirect.com/science/article/abs/pii/S0022356524183231

https://www.sciencedirect.com/science/article/pii/S1567724918301053

https://www.pnas.org/doi/abs/10.1073/pnas.1607571113

https://www.mdpi.com/2079-7737/8/2/27

https://pmc.ncbi.nlm.nih.gov/articles/PMC11336094/

https://pubmed.ncbi.nlm.nih.gov/39495479/

https://advancedbrain.com/blog/the-listening-program-safe-signal-cell-danger-response/

https://ncintegrative.org/wp-content/uploads/2024/06/Cell-Danger-Response-KING.pdf

https://www.nature.com/articles/s41433-024-03091-4

https://pmc.ncbi.nlm.nih.gov/articles/PMC7735836/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/

https://pmc.ncbi.nlm.nih.gov/articles/PMC5859128/

https://pmc.ncbi.nlm.nih.gov/articles/PMC4988248/

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