Episode 139

🧬 Redefining Biotech: Building Enduring Value Beyond Acquisition | Rabia Khan (Part 4/4)

"If you are that person, if you feel like you can't find your box and you're off doing these random things that no one else seems to find interesting, it's okay. Embrace it. It's who you are and it's going to be your superpower someday." In this episode of The Biotech Startups Podcast, host Jon Chee sits down with Rabia Khan, founder and CEO of Serna Bio, to discuss her journey from Sensyne Health to building a data-driven biotech company pioneering RNA-targeted drug discovery. Rabia shares how she overcame scientific and operational hurdles, navigated contract research limitations, and boldly moved Serna Bio from the UK to San Francisco. She also reveals her intentional approach to company culture, frugality, and long-term impact—emphasizing her vision to create a biotech business built for enduring innovation, not just acquisition.

The Biotech Startups Podcast · Excedr

April 24, 202547m 56s

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Show Notes

🧬 The Biotech Startups Podcast is powered by Excedr—helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.

As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.

In this episode of The Biotech Startups Podcast, host Jon Chee sits down with Rabia Khan, founder and CEO of Serna Bio, to discuss her journey from Sensyne Health to building a data-driven biotech company pioneering RNA-targeted drug discovery. Rabia shares how she overcame scientific and operational hurdles, navigated contract research limitations, and boldly moved Serna Bio from the UK to San Francisco. She also reveals her intentional approach to company culture, frugality, and long-term impact—emphasizing her vision to create a biotech business built for enduring innovation, not just acquisition.

Key topics covered:

Breaking Industry Molds: Serna Bio puts RNA at the center, challenging protein-focused norms.
Data-First Biotech: Massive RNA datasets drive unique insights.
Lean Operations & Frugality: Every dollar fuels innovation.
Company Building for Endurance: Built for long-term value, not quick exits.
Authentic Leadership: Bold, authentic leadership for lasting impact.

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Find our guest, Rabia Khan, at these links:

LinkedIn: https://www.linkedin.com/in/rabiatkhan/

Website: https://www.serna.bio/

Find our host, Jon Chee, at these links:

LinkedIn: https://www.linkedin.com/in/jonchee

Learn more about Excedr:

LinkedIn: https://www.linkedin.com/company/excedr/

Website: https://www.excedr.com

Intro & Outro Songs Created by OkKyojin, Owned by Excedr:

Website: https://flow.page/kyojin

Resources & Articles:

Principles by Ray Dalio: https://www.principles.com/

Amazon’s Six-Page Memo & Culture of Frugality: https://www.larksuite.com/en_us/blog/amazon-6-pager

The Druggable Genome: https://www.nature.com/articles/nrd892

Antifragile by Nassim Nicholas Taleb: https://www.goodreads.com/book/show/13530973-antifragile

Companies, Universities, & People mentioned:

Serna Bio: https://www.serna.bio/

Sensyne Health: https://www.sensynehealth.com/

BenevolentAI: https://www.benevolent.com/

Y Combinator: https://www.ycombinator.com/

Bridgewater Associates: https://www.bridgewater.com/

Genentech: https://www.gene.com/

BioMarin: https://www.biomarin.com/

Regeneron: https://www.regeneron.com/

Jackie Hunter: https://www.linkedin.com/in/drjackiehunter/

Barry Ticho: https://www.linkedin.com/in/barryticho

Ray Dalio: https://www.linkedin.com/in/raydalio/

Howard Marks: https://www.linkedin.com/in/howardmarksbook/

Nick Scott-Ram: https://www.linkedin.com/in/nick-scott-ram-637491b/?originalSubdomain=uk

Timestamps:

00:00 Intro

02:01 Leaving Sensyne & Founding Serna Bio

03:52 The Vision: Drugging RNA with Small Molecules

09:46 Challenging the Status Quo of Protein-Centric Drug Discovery

12:30 Building the Serna Toolkit: Data, Models, and Assays

15:14 Operational Hurdles: Working with CROs & Building In-House Labs

22:03 Leadership Philosophy: Frugality, Creativity & Building Culture

28:35 Building Labs: UK vs. SF & Strategic Evolution

36:56 Vision for Serna: Building an Enduring Biotech Company

43:19 Advice to Founders: Embrace Discomfort & Authenticity

45:53 Outro

The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

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