Episode 100

🧬 Barry Ticho - Part 3 | Lessons From Rigorous Drug Development | Industry vs. Academic Research Standards | A Patient-Centered Approach to Clinical Trials | How RNA is Shaping Modern Medicine

Part 3 of 4: Jon Chee hosts Barry Ticho, Founder of Verve Therapeutics and Chief Medical Officer at Stoke Therapeutics, a biotech company addressing the underlying cause of severe diseases by upregulating protein expression with RNA-based medicines. With an MD PhD from the University of Chicago and extensive experience across academia and industry, Barry brings over two decades of expertise in clinical development. His journey includes roles as Head of Development at Moderna, Head of External R&D Innovation at Pfizer, and VP of Clinical Development at Biogen, where he's been instrumental in advancing numerous therapeutic programs across multiple disease areas. Barry's unique perspective spanning academic medicine and biotechnology innovation makes his insights invaluable for aspiring leaders in the field.

The Biotech Startups Podcast · Excedr

December 2, 202437m 9s

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Show Notes

The Biotech Startups Podcast, brought to you by Excedr—empowering life science startups with founder-friendly equipment leasing to fast-track R&D and drive commercialization success.

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Part 3 of 4: Jon Chee hosts Barry Ticho, Founder of Verve Therapeutics and Chief Medical Officer at Stoke Therapeutics, a biotech company addressing the underlying cause of severe diseases by upregulating protein expression with RNA-based medicines.

With an MD PhD from the University of Chicago and extensive experience across academia and industry, Barry brings over two decades of expertise in clinical development. His journey includes roles as Head of Development at Moderna, Head of External R&D Innovation at Pfizer, and VP of Clinical Development at Biogen, where he's been instrumental in advancing numerous therapeutic programs across multiple disease areas.

Barry's unique perspective spanning academic medicine and biotechnology innovation makes his insights invaluable for aspiring leaders in the field.

Join us this week to hear about:

Barry’s switch from academia to industry, and the challenges of his role at Merck
Navigating drug development and the rigorous standards of pharmaceutical research
Leading patient-centered clinical development at Biogen to create impactful therapies
Exploring the potential of RNA medicine at Pfizer and Moderna
Working on Moderna’s lipid nanoparticle technology, the basis for the COVID-19 vaccine

Please enjoy Jon’s conversation with Barry Ticho.

Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994

Find Our Guest, Barry Ticho, at these links:

https://www.linkedin.com/in/barryticho/

https://www.stoketherapeutics.com/

https://www.vervetherapeutics.com/

Find Our Host, Jon Chee, at these links:

https://www.linkedin.com/in/jonchee

https://www.excedr.com

Excedr Socials & Website

LinkedIn: https://www.linkedin.com/company/excedr/

Youtube: https://www.youtube.com/@excedr

Instagram: https://www.instagram.com/excedr_inc

Twitter: https://twitter.com/ExcedrInc

Facebook: https://www.facebook.com/excedr

TikTok: https://www.tiktok.com/@excedr

Podcast Website: https://www.thebiotechstartupspodcast.com/

Topics Mentioned:

Merck: https://www.merck.com/

Biogen: https://www.biogen.com/

Pfizer: https://www.pfizer.com/

Wave Biosciences: https://wavelifesciences.com/

Moderna: https://www.modernatx.com/en-US

Verve Therapeutics: https://www.vervetx.com/

People Mentioned:

Stéphane Bancel: https://www.linkedin.com/in/st%C3%A9phane-bancel-8185251

Timestamps:

00:00 Intro

02:06 Transitioning from academia to Merck

03:41 Rigorous drug development processes at Merck

06:00 Industry vs. academia: reproducibility and research quality in pharma

08:35 Patient-centered clinical trials at Biogen

09:45 Phases of clinical trials and ensuring patient access

14:06 Challenges in drug approval: biology, regulations, and precision medicine

18:24 Biogen’s focus on impactful therapies for severe diseases

23:14 Joining Pfizer for cardiovascular research and RNA exploration

27:04 Exploring RNA therapeutics at Pfizer and transitioning to Moderna

30:21 Driving lipid nanoparticle breakthroughs at Moderna

36:23 Outro

The Biotech Startups Podcast gives you a front-row seat to the business and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.

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