This Fortnight in Medicine VI

Sensible Medicine · Adam Cifu, MD and John Mandrola

August 13, 202535m 6s

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Show Notes

A “manel” reviewing trials and studies that explore the benefits and harms of hormone replacement therapy.

The Women’s Health Initiative

* Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial

* The Women's Health Initiative Randomized Trials and Clinical Practice: A Review

* The Women’s Health Initiative Hormone Therapy Trials: Update and Overview of Health Outcomes During the Intervention and Post-Stopping Phases

Meta-analysese

* A systematic review and meta-regression analysis to examine the ‘timing hypothesis’ of hormone replacement therapy on mortality, coronary heart disease, and stroke

* Mortality Associated with Hormone Replacement Therapy in

Younger and Older Women

History: Observational HRT Data

* Postmenopausal estrogen and progestin use and the risk of cardiovascular disease

* Hormone therapy to prevent disease and prolong life in postmenopausal women

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